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Q9NQ30

- ESM1_HUMAN

UniProt

Q9NQ30 - ESM1_HUMAN

Protein

Endothelial cell-specific molecule 1

Gene

ESM1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 114 (01 Oct 2014)
      Sequence version 2 (27 Apr 2001)
      Previous versions | rss
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    Functioni

    Involved in angiogenesis; promotes angiogenic sprouting. May have potent implications in lung endothelial cell-leukocyte interactions.1 Publication

    GO - Molecular functioni

    1. hepatocyte growth factor receptor binding Source: UniProt
    2. integrin binding Source: UniProt

    GO - Biological processi

    1. angiogenesis Source: UniProtKB
    2. positive regulation of cell proliferation Source: UniProt
    3. positive regulation of hepatocyte growth factor receptor signaling pathway Source: UniProt
    4. regulation of cell growth Source: InterPro
    5. sprouting angiogenesis Source: UniProt

    Keywords - Biological processi

    Angiogenesis

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Endothelial cell-specific molecule 1
    Short name:
    ESM-1
    Gene namesi
    Name:ESM1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 5

    Organism-specific databases

    HGNCiHGNC:3466. ESM1.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA27883.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1919Sequence AnalysisAdd
    BLAST
    Chaini20 – 184165Endothelial cell-specific molecule 1PRO_0000014394Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi156 – 1561O-linked (Xyl...) (chondroitin sulfate)1 Publication

    Post-translational modificationi

    May contain intrachain disulfide bonds.
    O-glycosylated; contains chondroitin sulfate and dermatan sulfate.1 Publication

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ9NQ30.
    PRIDEiQ9NQ30.

    Expressioni

    Tissue specificityi

    Expressed in lung, on the vascular capillary network within alveolar walls, and also at lower level in kidney.

    Inductioni

    By TNF and IL1B/interleukin-1 beta, but not IL4/interleukin-4.

    Gene expression databases

    ArrayExpressiQ9NQ30.
    BgeeiQ9NQ30.
    CleanExiHS_ESM1.
    GenevestigatoriQ9NQ30.

    Organism-specific databases

    HPAiHPA036660.

    Interactioni

    Subunit structurei

    Monomer.

    Protein-protein interaction databases

    BioGridi116265. 1 interaction.
    STRINGi9606.ENSP00000370812.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9NQ30.
    SMRiQ9NQ30. Positions 101-142.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini24 – 10279IGFBP N-terminalPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 IGFBP N-terminal domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG255925.
    HOGENOMiHOG000273901.
    HOVERGENiHBG005610.
    InParanoidiQ9NQ30.
    OMAiSTKYAVD.
    OrthoDBiEOG7BW0M2.
    PhylomeDBiQ9NQ30.

    Family and domain databases

    InterProiIPR009030. Growth_fac_rcpt_N_dom.
    IPR000867. IGFBP-like.
    [Graphical view]
    PfamiPF00219. IGFBP. 1 hit.
    [Graphical view]
    SMARTiSM00121. IB. 1 hit.
    [Graphical view]
    SUPFAMiSSF57184. SSF57184. 1 hit.
    PROSITEiPS51323. IGFBP_N_2. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9NQ30-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MKSVLLLTTL LVPAHLVAAW SNNYAVDCPQ HCDSSECKSS PRCKRTVLDD    50
    CGCCRVCAAG RGETCYRTVS GMDGMKCGPG LRCQPSNGED PFGEEFGICK 100
    DCPYGTFGMD CRETCNCQSG ICDRGTGKCL KFPFFQYSVT KSSNRFVSLT 150
    EHDMASGDGN IVREEVVKEN AAGSPVMRKW LNPR 184
    Length:184
    Mass (Da):20,095
    Last modified:April 27, 2001 - v2
    Checksum:i2AD15EDEC74BC8CE
    GO
    Isoform 2 (identifier: Q9NQ30-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         101-150: Missing.

    Show »
    Length:134
    Mass (Da):14,513
    Checksum:i93F9A5E8396BD330
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti44 – 441K → E in AAH11989. (PubMed:15489334)Curated
    Sequence conflicti151 – 1511Missing in CAB94771. 1 PublicationCurated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei101 – 15050Missing in isoform 2. 2 PublicationsVSP_042631Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X89426 mRNA. Translation: CAA61597.1.
    AJ401091, AJ401092 Genomic DNA. Translation: CAB94771.1.
    AJ973643 mRNA. Translation: CAJ13737.1.
    AK300634 mRNA. Translation: BAG62324.1.
    AK311817 mRNA. Translation: BAG34760.1.
    AC010436 Genomic DNA. No translation available.
    AC034238 Genomic DNA. No translation available.
    BC011989 mRNA. Translation: AAH11989.1.
    CCDSiCCDS3963.1. [Q9NQ30-1]
    CCDS47206.1. [Q9NQ30-2]
    RefSeqiNP_001129076.1. NM_001135604.1. [Q9NQ30-2]
    NP_008967.1. NM_007036.4. [Q9NQ30-1]
    UniGeneiHs.129944.

    Genome annotation databases

    EnsembliENST00000381403; ENSP00000370810; ENSG00000164283. [Q9NQ30-2]
    ENST00000381405; ENSP00000370812; ENSG00000164283. [Q9NQ30-1]
    GeneIDi11082.
    KEGGihsa:11082.
    UCSCiuc003jpk.3. human. [Q9NQ30-1]
    uc010ivt.3. human. [Q9NQ30-2]

    Polymorphism databases

    DMDMi13431509.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X89426 mRNA. Translation: CAA61597.1 .
    AJ401091 , AJ401092 Genomic DNA. Translation: CAB94771.1 .
    AJ973643 mRNA. Translation: CAJ13737.1 .
    AK300634 mRNA. Translation: BAG62324.1 .
    AK311817 mRNA. Translation: BAG34760.1 .
    AC010436 Genomic DNA. No translation available.
    AC034238 Genomic DNA. No translation available.
    BC011989 mRNA. Translation: AAH11989.1 .
    CCDSi CCDS3963.1. [Q9NQ30-1 ]
    CCDS47206.1. [Q9NQ30-2 ]
    RefSeqi NP_001129076.1. NM_001135604.1. [Q9NQ30-2 ]
    NP_008967.1. NM_007036.4. [Q9NQ30-1 ]
    UniGenei Hs.129944.

    3D structure databases

    ProteinModelPortali Q9NQ30.
    SMRi Q9NQ30. Positions 101-142.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 116265. 1 interaction.
    STRINGi 9606.ENSP00000370812.

    Polymorphism databases

    DMDMi 13431509.

    Proteomic databases

    PaxDbi Q9NQ30.
    PRIDEi Q9NQ30.

    Protocols and materials databases

    DNASUi 11082.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000381403 ; ENSP00000370810 ; ENSG00000164283 . [Q9NQ30-2 ]
    ENST00000381405 ; ENSP00000370812 ; ENSG00000164283 . [Q9NQ30-1 ]
    GeneIDi 11082.
    KEGGi hsa:11082.
    UCSCi uc003jpk.3. human. [Q9NQ30-1 ]
    uc010ivt.3. human. [Q9NQ30-2 ]

    Organism-specific databases

    CTDi 11082.
    GeneCardsi GC05M054309.
    H-InvDB HIX0004861.
    HGNCi HGNC:3466. ESM1.
    HPAi HPA036660.
    MIMi 601521. gene.
    neXtProti NX_Q9NQ30.
    PharmGKBi PA27883.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG255925.
    HOGENOMi HOG000273901.
    HOVERGENi HBG005610.
    InParanoidi Q9NQ30.
    OMAi STKYAVD.
    OrthoDBi EOG7BW0M2.
    PhylomeDBi Q9NQ30.

    Miscellaneous databases

    GeneWikii ESM1.
    GenomeRNAii 11082.
    NextBioi 42134.
    PROi Q9NQ30.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9NQ30.
    Bgeei Q9NQ30.
    CleanExi HS_ESM1.
    Genevestigatori Q9NQ30.

    Family and domain databases

    InterProi IPR009030. Growth_fac_rcpt_N_dom.
    IPR000867. IGFBP-like.
    [Graphical view ]
    Pfami PF00219. IGFBP. 1 hit.
    [Graphical view ]
    SMARTi SM00121. IB. 1 hit.
    [Graphical view ]
    SUPFAMi SSF57184. SSF57184. 1 hit.
    PROSITEi PS51323. IGFBP_N_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "ESM-1 is a novel human endothelial cell-specific molecule expressed in lung and regulated by cytokines."
      Lassalle P., Molet S., Janin A., Vander-Heyden J.E., Tavernier J., Fiers W., Devos R.E., Tonnel A.-B.
      J. Biol. Chem. 271:20458-20464(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Umbilical vein endothelial cell.
    2. "Sequencing of the human ESM-1 gene and analysis of its 5' flanking region."
      Vedrenne C., Kervoaze G., Lassalle P.
      Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Tissue: Leukocyte.
    3. "Exon 2 of the endocan gene contributes to tumorigenesis and its expression is increased in human lung tumor vascular cells."
      Depontieu F., Grigoriu B., Scherpereel A., Adam E., Lafitte J.J., Ouatas T., Delehedde M., Lyon M., Copin M.C., Janin A., Tonnel A.B., Tsicopoulos A., Lassalle P.
      Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: Thalamus.
    5. "The DNA sequence and comparative analysis of human chromosome 5."
      Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.
      , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.
      Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Lung.
    7. "Integrin cytoplasmic domain-associated protein-1 attenuates sprouting angiogenesis."
      Brutsch R., Liebler S.S., Wustehube J., Bartol A., Herberich S.E., Adam M.G., Telzerow A., Augustin H.G., Fischer A.
      Circ. Res. 107:592-601(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    8. "Characterization and binding activity of the chondroitin/dermatan sulfate chain from Endocan, a soluble endothelial proteoglycan."
      Sarrazin S., Lyon M., Deakin J.A., Guerrini M., Lassalle P., Delehedde M., Lortat-Jacob H.
      Glycobiology 20:1380-1388(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION AT SER-156.

    Entry informationi

    Entry nameiESM1_HUMAN
    AccessioniPrimary (citable) accession number: Q9NQ30
    Secondary accession number(s): B2R4G3
    , Q15330, Q3V4E3, Q96ES3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 27, 2001
    Last sequence update: April 27, 2001
    Last modified: October 1, 2014
    This is version 114 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 5
      Human chromosome 5: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3