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Q9NQ30

- ESM1_HUMAN

UniProt

Q9NQ30 - ESM1_HUMAN

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Protein
Endothelial cell-specific molecule 1
Gene
ESM1
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Involved in angiogenesis; promotes angiogenic sprouting. May have potent implications in lung endothelial cell-leukocyte interactions.1 Publication

GO - Molecular functioni

  1. hepatocyte growth factor receptor binding Source: UniProt
  2. integrin binding Source: UniProt

GO - Biological processi

  1. angiogenesis Source: UniProtKB
  2. positive regulation of cell proliferation Source: UniProt
  3. positive regulation of hepatocyte growth factor receptor signaling pathway Source: UniProt
  4. regulation of cell growth Source: InterPro
  5. sprouting angiogenesis Source: UniProt
Complete GO annotation...

Keywords - Biological processi

Angiogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Endothelial cell-specific molecule 1
Short name:
ESM-1
Gene namesi
Name:ESM1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 5

Organism-specific databases

HGNCiHGNC:3466. ESM1.

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA27883.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919 Reviewed prediction
Add
BLAST
Chaini20 – 184165Endothelial cell-specific molecule 1
PRO_0000014394Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi156 – 1561O-linked (Xyl...) (chondroitin sulfate)1 Publication

Post-translational modificationi

May contain intrachain disulfide bonds.
O-glycosylated; contains chondroitin sulfate and dermatan sulfate.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9NQ30.
PRIDEiQ9NQ30.

Expressioni

Tissue specificityi

Expressed in lung, on the vascular capillary network within alveolar walls, and also at lower level in kidney.

Inductioni

By TNF and IL1B/interleukin-1 beta, but not IL4/interleukin-4.

Gene expression databases

ArrayExpressiQ9NQ30.
BgeeiQ9NQ30.
CleanExiHS_ESM1.
GenevestigatoriQ9NQ30.

Organism-specific databases

HPAiHPA036660.

Interactioni

Subunit structurei

Monomer.

Protein-protein interaction databases

BioGridi116265. 1 interaction.
STRINGi9606.ENSP00000370812.

Structurei

3D structure databases

ProteinModelPortaliQ9NQ30.
SMRiQ9NQ30. Positions 101-142.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini24 – 10279IGFBP N-terminal
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG255925.
HOGENOMiHOG000273901.
HOVERGENiHBG005610.
InParanoidiQ9NQ30.
OMAiSTKYAVD.
OrthoDBiEOG7BW0M2.
PhylomeDBiQ9NQ30.

Family and domain databases

InterProiIPR009030. Growth_fac_rcpt_N_dom.
IPR000867. IGFBP-like.
[Graphical view]
PfamiPF00219. IGFBP. 1 hit.
[Graphical view]
SMARTiSM00121. IB. 1 hit.
[Graphical view]
SUPFAMiSSF57184. SSF57184. 1 hit.
PROSITEiPS51323. IGFBP_N_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9NQ30-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MKSVLLLTTL LVPAHLVAAW SNNYAVDCPQ HCDSSECKSS PRCKRTVLDD    50
CGCCRVCAAG RGETCYRTVS GMDGMKCGPG LRCQPSNGED PFGEEFGICK 100
DCPYGTFGMD CRETCNCQSG ICDRGTGKCL KFPFFQYSVT KSSNRFVSLT 150
EHDMASGDGN IVREEVVKEN AAGSPVMRKW LNPR 184
Length:184
Mass (Da):20,095
Last modified:April 27, 2001 - v2
Checksum:i2AD15EDEC74BC8CE
GO
Isoform 2 (identifier: Q9NQ30-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     101-150: Missing.

Show »
Length:134
Mass (Da):14,513
Checksum:i93F9A5E8396BD330
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei101 – 15050Missing in isoform 2.
VSP_042631Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti44 – 441K → E in AAH11989. 1 Publication
Sequence conflicti151 – 1511Missing in CAB94771. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X89426 mRNA. Translation: CAA61597.1.
AJ401091, AJ401092 Genomic DNA. Translation: CAB94771.1.
AJ973643 mRNA. Translation: CAJ13737.1.
AK300634 mRNA. Translation: BAG62324.1.
AK311817 mRNA. Translation: BAG34760.1.
AC010436 Genomic DNA. No translation available.
AC034238 Genomic DNA. No translation available.
BC011989 mRNA. Translation: AAH11989.1.
CCDSiCCDS3963.1. [Q9NQ30-1]
CCDS47206.1. [Q9NQ30-2]
RefSeqiNP_001129076.1. NM_001135604.1. [Q9NQ30-2]
NP_008967.1. NM_007036.4. [Q9NQ30-1]
UniGeneiHs.129944.

Genome annotation databases

EnsembliENST00000381403; ENSP00000370810; ENSG00000164283. [Q9NQ30-2]
ENST00000381405; ENSP00000370812; ENSG00000164283. [Q9NQ30-1]
GeneIDi11082.
KEGGihsa:11082.
UCSCiuc003jpk.3. human. [Q9NQ30-1]
uc010ivt.3. human. [Q9NQ30-2]

Polymorphism databases

DMDMi13431509.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X89426 mRNA. Translation: CAA61597.1 .
AJ401091 , AJ401092 Genomic DNA. Translation: CAB94771.1 .
AJ973643 mRNA. Translation: CAJ13737.1 .
AK300634 mRNA. Translation: BAG62324.1 .
AK311817 mRNA. Translation: BAG34760.1 .
AC010436 Genomic DNA. No translation available.
AC034238 Genomic DNA. No translation available.
BC011989 mRNA. Translation: AAH11989.1 .
CCDSi CCDS3963.1. [Q9NQ30-1 ]
CCDS47206.1. [Q9NQ30-2 ]
RefSeqi NP_001129076.1. NM_001135604.1. [Q9NQ30-2 ]
NP_008967.1. NM_007036.4. [Q9NQ30-1 ]
UniGenei Hs.129944.

3D structure databases

ProteinModelPortali Q9NQ30.
SMRi Q9NQ30. Positions 101-142.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 116265. 1 interaction.
STRINGi 9606.ENSP00000370812.

Polymorphism databases

DMDMi 13431509.

Proteomic databases

PaxDbi Q9NQ30.
PRIDEi Q9NQ30.

Protocols and materials databases

DNASUi 11082.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000381403 ; ENSP00000370810 ; ENSG00000164283 . [Q9NQ30-2 ]
ENST00000381405 ; ENSP00000370812 ; ENSG00000164283 . [Q9NQ30-1 ]
GeneIDi 11082.
KEGGi hsa:11082.
UCSCi uc003jpk.3. human. [Q9NQ30-1 ]
uc010ivt.3. human. [Q9NQ30-2 ]

Organism-specific databases

CTDi 11082.
GeneCardsi GC05M054309.
H-InvDB HIX0004861.
HGNCi HGNC:3466. ESM1.
HPAi HPA036660.
MIMi 601521. gene.
neXtProti NX_Q9NQ30.
PharmGKBi PA27883.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG255925.
HOGENOMi HOG000273901.
HOVERGENi HBG005610.
InParanoidi Q9NQ30.
OMAi STKYAVD.
OrthoDBi EOG7BW0M2.
PhylomeDBi Q9NQ30.

Miscellaneous databases

GeneWikii ESM1.
GenomeRNAii 11082.
NextBioi 42134.
PROi Q9NQ30.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9NQ30.
Bgeei Q9NQ30.
CleanExi HS_ESM1.
Genevestigatori Q9NQ30.

Family and domain databases

InterProi IPR009030. Growth_fac_rcpt_N_dom.
IPR000867. IGFBP-like.
[Graphical view ]
Pfami PF00219. IGFBP. 1 hit.
[Graphical view ]
SMARTi SM00121. IB. 1 hit.
[Graphical view ]
SUPFAMi SSF57184. SSF57184. 1 hit.
PROSITEi PS51323. IGFBP_N_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "ESM-1 is a novel human endothelial cell-specific molecule expressed in lung and regulated by cytokines."
    Lassalle P., Molet S., Janin A., Vander-Heyden J.E., Tavernier J., Fiers W., Devos R.E., Tonnel A.-B.
    J. Biol. Chem. 271:20458-20464(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Umbilical vein endothelial cell.
  2. "Sequencing of the human ESM-1 gene and analysis of its 5' flanking region."
    Vedrenne C., Kervoaze G., Lassalle P.
    Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Tissue: Leukocyte.
  3. "Exon 2 of the endocan gene contributes to tumorigenesis and its expression is increased in human lung tumor vascular cells."
    Depontieu F., Grigoriu B., Scherpereel A., Adam E., Lafitte J.J., Ouatas T., Delehedde M., Lyon M., Copin M.C., Janin A., Tonnel A.B., Tsicopoulos A., Lassalle P.
    Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Thalamus.
  5. "The DNA sequence and comparative analysis of human chromosome 5."
    Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.
    , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.
    Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Lung.
  7. "Integrin cytoplasmic domain-associated protein-1 attenuates sprouting angiogenesis."
    Brutsch R., Liebler S.S., Wustehube J., Bartol A., Herberich S.E., Adam M.G., Telzerow A., Augustin H.G., Fischer A.
    Circ. Res. 107:592-601(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  8. "Characterization and binding activity of the chondroitin/dermatan sulfate chain from Endocan, a soluble endothelial proteoglycan."
    Sarrazin S., Lyon M., Deakin J.A., Guerrini M., Lassalle P., Delehedde M., Lortat-Jacob H.
    Glycobiology 20:1380-1388(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION AT SER-156.

Entry informationi

Entry nameiESM1_HUMAN
AccessioniPrimary (citable) accession number: Q9NQ30
Secondary accession number(s): B2R4G3
, Q15330, Q3V4E3, Q96ES3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: April 27, 2001
Last modified: July 9, 2014
This is version 113 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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