Q9NQ29 (LUC7L_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Putative RNA-binding protein Luc7-like 1

Alternative name(s):
Putative SR protein LUC7B1
SR+89

Gene names

Name:	LUC7L
Synonyms:	LUC7L1

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	371 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May bind to RNA via its Arg/Ser-rich domain. Ref.2
Tissue specificity	Ubiquitous. Ref.2
Sequence similarities	Belongs to the Luc7 family. Contains 1 C2H2-type zinc finger.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing
Domain	Coiled coil Zinc-finger
Ligand	Metal-binding Zinc
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Molecular function	metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
NFKBIL1	Q9UBC1	1	EBI-473747,EBI-1043728
RNPS1	Q15287	1	EBI-473747,EBI-395959

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9NQ29-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9NQ29-2)

The sequence of this isoform differs from the canonical sequence as follows:
     326-371: Missing.

Note: May be due to an intron retention.

Isoform 3 (identifier: Q9NQ29-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-20: MSAQAQMRALLDQLMGTARD → MQM

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 371	371	Putative RNA-binding protein Luc7-like 1		PRO_0000187280
Regions
	Zinc finger	188 – 215	28	C2H2-type; atypical
	Coiled coil	87 – 177	91	Potential
	Coiled coil	218 – 259	42	Potential
	Compositional bias	243 – 362	120	Arg/Ser-rich
Amino acid modifications
	Modified residue	363	1	Phosphoserine Ref.8 Ref.9
Natural variations
	Alternative sequence	1 – 20	20	MSAQA…GTARD → MQM in isoform 3.		VSP_010214
	Alternative sequence	326 – 371	46	Missing in isoform 2.		VSP_010215
Experimental info
	Sequence conflict	171	1	E → V in AAK61218. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified October 1, 2000. Version 1. Checksum: C277F424F5F5659C	FASTA	371	43,728
	10 20 30 40 50 60 MSAQAQMRAL LDQLMGTARD GDETRQRVKF TDDRVCKSHL LDCCPHDILA GTRMDLGECT 70 80 90 100 110 120 KIHDLALRAD YEIASKERDL FFELDAMDHL ESFIAECDRR TELAKKRLAE TQEEISAEVS 130 140 150 160 170 180 AKAEKVHELN EEIGKLLAKA EQLGAEGNVD ESQKILMEVE KVRAKKKEAE EEYRNSMPAS 190 200 210 220 230 240 SFQQQKLRVC EVCSAYLGLH DNDRRLADHF GGKLHLGFIQ IREKLDQLRK TVAEKQEKRN 250 260 270 280 290 300 QDRLRRREER EREERLSRRS GSRTRDRRRS RSRDRRRRRS RSTSRERRKL SRSRSRDRHR 310 320 330 340 350 360 RHRSRSRSHS RGHRRASRDR SAKYKFSRER ASREESWESG RSERGPPDWR LESSNGKMAS 370 RRSEEKEAGE I
	Isoform 2 [UniParc]. Checksum: 35D03C10999A44B6	FASTA	325	38,405
	10 20 30 40 50 60 MSAQAQMRAL LDQLMGTARD GDETRQRVKF TDDRVCKSHL LDCCPHDILA GTRMDLGECT 70 80 90 100 110 120 KIHDLALRAD YEIASKERDL FFELDAMDHL ESFIAECDRR TELAKKRLAE TQEEISAEVS 130 140 150 160 170 180 AKAEKVHELN EEIGKLLAKA EQLGAEGNVD ESQKILMEVE KVRAKKKEAE EEYRNSMPAS 190 200 210 220 230 240 SFQQQKLRVC EVCSAYLGLH DNDRRLADHF GGKLHLGFIQ IREKLDQLRK TVAEKQEKRN 250 260 270 280 290 300 QDRLRRREER EREERLSRRS GSRTRDRRRS RSRDRRRRRS RSTSRERRKL SRSRSRDRHR 310 320 RHRSRSRSHS RGHRRASRDR SAKYK
	Isoform 3 [UniParc]. Checksum: B73044140DECCC9F	FASTA	354	41,929
	10 20 30 40 50 60 MQMGDETRQR VKFTDDRVCK SHLLDCCPHD ILAGTRMDLG ECTKIHDLAL RADYEIASKE 70 80 90 100 110 120 RDLFFELDAM DHLESFIAEC DRRTELAKKR LAETQEEISA EVSAKAEKVH ELNEEIGKLL 130 140 150 160 170 180 AKAEQLGAEG NVDESQKILM EVEKVRAKKK EAEEEYRNSM PASSFQQQKL RVCEVCSAYL 190 200 210 220 230 240 GLHDNDRRLA DHFGGKLHLG FIQIREKLDQ LRKTVAEKQE KRNQDRLRRR EEREREERLS 250 260 270 280 290 300 RRSGSRTRDR RRSRSRDRRR RRSRSTSRER RKLSRSRSRD RHRRHRSRSR SHSRGHRRAS 310 320 330 340 350 RDRSAKYKFS RERASREESW ESGRSERGPP DWRLESSNGK MASRRSEEKE AGEI

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"SR+89, a gene encoding a serine/arginine-rich protein, is widely transcribed from human chromosome 16p13.3 proximal to the alpha-globin cluster. Exclusion of this new gene as a candidate gene for the hypospadic phenotype associated with homozygous SEA-alpha-thalassaemia." Utsch B., Albers N., Wickert L., Bidlingmaier F., Ludwig M. Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE (ISOFORM 2).
[2]	"Characterization of a widely expressed gene (LUC7-LIKE; LUC7L) defining the centromeric boundary of the human alpha-globin domain." Tufarelli C., Frischauf A.-M., Hardison R., Flint J., Higgs D.R. Genomics 71:307-314(2001) [PubMed: 11170747] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, TISSUE SPECIFICITY.
[3]	"Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16." Daniels R.J., Peden J.F., Lloyd C., Horsley S.W., Clark K., Tufarelli C., Kearney L., Buckle V.J., Doggett N.A., Flint J., Higgs D.R. Hum. Mol. Genet. 10:339-352(2001) [PubMed: 11157797] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Embryo.
[6]	"The sequence and analysis of duplication-rich human chromosome 16." Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J. , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A. Nature 432:988-994(2004) [PubMed: 15616553] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3). Tissue: Blood and Lung.
[8]	"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M. Cell 127:635-648(2006) [PubMed: 17081983] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-363, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[9]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-363, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[10]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed: 21269460] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ404326 mRNA. Translation: CAB93981.1. AJ404326 mRNA. Translation: CAB93982.1. AY005111 mRNA. Translation: AAG22846.1. AE006462 Genomic DNA. Translation: AAK61218.1. AK001093 mRNA. Translation: BAA91500.1. Z69890, Z69706 Genomic DNA. Translation: CAM26671.1. CH471112 Genomic DNA. Translation: EAW85853.1. BC003194 mRNA. Translation: AAH03194.1. BC065198 mRNA. Translation: AAH65198.1.
IPI	IPI00071318. IPI00410026. IPI00410027.
RefSeq	NP_060502.1. NM_018032.3. NP_958815.1. NM_201412.1.
UniGene	Hs.16803.
3D structure databases
ProteinModelPortal	Q9NQ29.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9NQ29. 6 interactions.
MINT	MINT-3071845.
STRING	Q9NQ29.
PTM databases
PhosphoSite	Q9NQ29.
Polymorphism databases
DMDM	47116932.
Proteomic databases
PRIDE	Q9NQ29.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000293872; ENSP00000293872; ENSG00000007392.
GeneID	55692.
KEGG	hsa:55692.
UCSC	uc002cgc.1. human.
Organism-specific databases
CTD	55692.
GeneCards	GC16M000178.
HGNC	HGNC:6723. LUC7L.
HPA	CAB033659.
MIM	607782. gene.
neXtProt	NX_Q9NQ29.
GenAtlas	Search...
Phylogenomic databases
GeneTree	ENSGT00570000078887.
HOGENOM	HBG714380.
HOVERGEN	HBG062167.
InParanoid	Q9NQ29.
OMA	SERRHES.
OrthoDB	EOG4J1192.
PhylomeDB	Q9NQ29.
Gene expression databases
ArrayExpress	Q9NQ29.
Bgee	Q9NQ29.
CleanEx	HS_LUC7L.
Genevestigator	Q9NQ29.
GermOnline	ENSG00000007392. Homo sapiens.
Family and domain databases
InterPro	IPR004882. LUC7-rel. [Graphical view]
PANTHER	PTHR12375. LUC7_rel. 1 hit.
Pfam	PF03194. LUC7. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	60505.
SOURCE	Search...

Entry information

Entry name

LUC7L_HUMAN

Accession

Primary (citable) accession number: Q9NQ29
Secondary accession number(s): B8ZZ13, Q96S32, Q9NPH4

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 10, 2004
Last sequence update:	October 1, 2000
Last modified:	December 14, 2011
This is version 80 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.