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Q9NQ29

- LUC7L_HUMAN

UniProt

Q9NQ29 - LUC7L_HUMAN

Protein

Putative RNA-binding protein Luc7-like 1

Gene

LUC7L

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 107 (01 Oct 2014)
      Sequence version 1 (01 Oct 2000)
      Previous versions | rss
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    Functioni

    May bind to RNA via its Arg/Ser-rich domain.1 Publication

    GO - Molecular functioni

    1. identical protein binding Source: IntAct
    2. mRNA binding Source: InterPro
    3. protein binding Source: IntAct

    GO - Biological processi

    1. mRNA splice site selection Source: InterPro
    2. negative regulation of striated muscle tissue development Source: Ensembl

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Putative RNA-binding protein Luc7-like 1
    Alternative name(s):
    Putative SR protein LUC7B1
    SR+89
    Gene namesi
    Name:LUC7L
    Synonyms:LUC7L1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 16

    Organism-specific databases

    HGNCiHGNC:6723. LUC7L.

    Subcellular locationi

    GO - Cellular componenti

    1. U1 snRNP Source: InterPro

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA30485.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 371371Putative RNA-binding protein Luc7-like 1PRO_0000187280Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei363 – 3631Phosphoserine4 Publications

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ9NQ29.
    PaxDbiQ9NQ29.
    PRIDEiQ9NQ29.

    PTM databases

    PhosphoSiteiQ9NQ29.

    Expressioni

    Tissue specificityi

    Ubiquitous.1 Publication

    Gene expression databases

    ArrayExpressiQ9NQ29.
    BgeeiQ9NQ29.
    CleanExiHS_LUC7L.
    GenevestigatoriQ9NQ29.

    Organism-specific databases

    HPAiCAB033659.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    itself2EBI-473747,EBI-473747
    CHERPQ8IWX82EBI-473747,EBI-2555370
    SRPK1Q96SB42EBI-473747,EBI-539478
    SRPK2P783622EBI-473747,EBI-593303

    Protein-protein interaction databases

    BioGridi120818. 22 interactions.
    IntActiQ9NQ29. 14 interactions.
    MINTiMINT-3071845.
    STRINGi9606.ENSP00000293872.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9NQ29.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili87 – 17791Sequence AnalysisAdd
    BLAST
    Coiled coili218 – 25942Sequence AnalysisAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi243 – 362120Arg/Ser-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the Luc7 family.Curated

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiCOG5200.
    HOGENOMiHOG000215956.
    HOVERGENiHBG062167.
    InParanoidiQ9NQ29.
    OMAiRHESTNG.
    PhylomeDBiQ9NQ29.
    TreeFamiTF317607.

    Family and domain databases

    InterProiIPR004882. Luc7-rel.
    [Graphical view]
    PANTHERiPTHR12375. PTHR12375. 1 hit.
    PfamiPF03194. LUC7. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9NQ29-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSAQAQMRAL LDQLMGTARD GDETRQRVKF TDDRVCKSHL LDCCPHDILA    50
    GTRMDLGECT KIHDLALRAD YEIASKERDL FFELDAMDHL ESFIAECDRR 100
    TELAKKRLAE TQEEISAEVS AKAEKVHELN EEIGKLLAKA EQLGAEGNVD 150
    ESQKILMEVE KVRAKKKEAE EEYRNSMPAS SFQQQKLRVC EVCSAYLGLH 200
    DNDRRLADHF GGKLHLGFIQ IREKLDQLRK TVAEKQEKRN QDRLRRREER 250
    EREERLSRRS GSRTRDRRRS RSRDRRRRRS RSTSRERRKL SRSRSRDRHR 300
    RHRSRSRSHS RGHRRASRDR SAKYKFSRER ASREESWESG RSERGPPDWR 350
    LESSNGKMAS RRSEEKEAGE I 371
    Length:371
    Mass (Da):43,728
    Last modified:October 1, 2000 - v1
    Checksum:iC277F424F5F5659C
    GO
    Isoform 2 (identifier: Q9NQ29-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         326-371: Missing.

    Note: May be due to an intron retention.

    Show »
    Length:325
    Mass (Da):38,405
    Checksum:i35D03C10999A44B6
    GO
    Isoform 3 (identifier: Q9NQ29-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-20: MSAQAQMRALLDQLMGTARD → MQM

    Note: No experimental confirmation available.

    Show »
    Length:354
    Mass (Da):41,929
    Checksum:iB73044140DECCC9F
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti171 – 1711E → V in AAK61218. (PubMed:11157797)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 2020MSAQA…GTARD → MQM in isoform 3. 1 PublicationVSP_010214Add
    BLAST
    Alternative sequencei326 – 37146Missing in isoform 2. 2 PublicationsVSP_010215Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ404326 mRNA. Translation: CAB93981.1.
    AJ404326 mRNA. Translation: CAB93982.1.
    AY005111 mRNA. Translation: AAG22846.1.
    AE006462 Genomic DNA. Translation: AAK61218.1.
    AK001093 mRNA. Translation: BAA91500.1.
    Z69890, Z69706 Genomic DNA. Translation: CAM26671.1.
    CH471112 Genomic DNA. Translation: EAW85853.1.
    BC003194 mRNA. Translation: AAH03194.1.
    BC065198 mRNA. Translation: AAH65198.1.
    CCDSiCCDS10401.1. [Q9NQ29-2]
    CCDS32348.1. [Q9NQ29-1]
    RefSeqiNP_060502.1. NM_018032.3. [Q9NQ29-2]
    NP_958815.1. NM_201412.1. [Q9NQ29-1]
    XP_005255483.1. XM_005255426.1. [Q9NQ29-2]
    UniGeneiHs.16803.

    Genome annotation databases

    EnsembliENST00000293872; ENSP00000293872; ENSG00000007392. [Q9NQ29-1]
    ENST00000337351; ENSP00000337507; ENSG00000007392. [Q9NQ29-2]
    ENST00000397783; ENSP00000380885; ENSG00000007392. [Q9NQ29-2]
    GeneIDi55692.
    KEGGihsa:55692.
    UCSCiuc002cga.1. human. [Q9NQ29-1]

    Polymorphism databases

    DMDMi47116932.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ404326 mRNA. Translation: CAB93981.1 .
    AJ404326 mRNA. Translation: CAB93982.1 .
    AY005111 mRNA. Translation: AAG22846.1 .
    AE006462 Genomic DNA. Translation: AAK61218.1 .
    AK001093 mRNA. Translation: BAA91500.1 .
    Z69890 , Z69706 Genomic DNA. Translation: CAM26671.1 .
    CH471112 Genomic DNA. Translation: EAW85853.1 .
    BC003194 mRNA. Translation: AAH03194.1 .
    BC065198 mRNA. Translation: AAH65198.1 .
    CCDSi CCDS10401.1. [Q9NQ29-2 ]
    CCDS32348.1. [Q9NQ29-1 ]
    RefSeqi NP_060502.1. NM_018032.3. [Q9NQ29-2 ]
    NP_958815.1. NM_201412.1. [Q9NQ29-1 ]
    XP_005255483.1. XM_005255426.1. [Q9NQ29-2 ]
    UniGenei Hs.16803.

    3D structure databases

    ProteinModelPortali Q9NQ29.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 120818. 22 interactions.
    IntActi Q9NQ29. 14 interactions.
    MINTi MINT-3071845.
    STRINGi 9606.ENSP00000293872.

    PTM databases

    PhosphoSitei Q9NQ29.

    Polymorphism databases

    DMDMi 47116932.

    Proteomic databases

    MaxQBi Q9NQ29.
    PaxDbi Q9NQ29.
    PRIDEi Q9NQ29.

    Protocols and materials databases

    DNASUi 55692.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000293872 ; ENSP00000293872 ; ENSG00000007392 . [Q9NQ29-1 ]
    ENST00000337351 ; ENSP00000337507 ; ENSG00000007392 . [Q9NQ29-2 ]
    ENST00000397783 ; ENSP00000380885 ; ENSG00000007392 . [Q9NQ29-2 ]
    GeneIDi 55692.
    KEGGi hsa:55692.
    UCSCi uc002cga.1. human. [Q9NQ29-1 ]

    Organism-specific databases

    CTDi 55692.
    GeneCardsi GC16M000238.
    HGNCi HGNC:6723. LUC7L.
    HPAi CAB033659.
    MIMi 607782. gene.
    neXtProti NX_Q9NQ29.
    PharmGKBi PA30485.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5200.
    HOGENOMi HOG000215956.
    HOVERGENi HBG062167.
    InParanoidi Q9NQ29.
    OMAi RHESTNG.
    PhylomeDBi Q9NQ29.
    TreeFami TF317607.

    Miscellaneous databases

    ChiTaRSi LUC7L. human.
    GeneWikii LUC7L.
    GenomeRNAii 55692.
    NextBioi 60505.
    PROi Q9NQ29.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9NQ29.
    Bgeei Q9NQ29.
    CleanExi HS_LUC7L.
    Genevestigatori Q9NQ29.

    Family and domain databases

    InterProi IPR004882. Luc7-rel.
    [Graphical view ]
    PANTHERi PTHR12375. PTHR12375. 1 hit.
    Pfami PF03194. LUC7. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "SR+89, a gene encoding a serine/arginine-rich protein, is widely transcribed from human chromosome 16p13.3 proximal to the alpha-globin cluster. Exclusion of this new gene as a candidate gene for the hypospadic phenotype associated with homozygous SEA-alpha-thalassaemia."
      Utsch B., Albers N., Wickert L., Bidlingmaier F., Ludwig M.
      Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE (ISOFORM 2).
    2. "Characterization of a widely expressed gene (LUC7-LIKE; LUC7L) defining the centromeric boundary of the human alpha-globin domain."
      Tufarelli C., Frischauf A.-M., Hardison R., Flint J., Higgs D.R.
      Genomics 71:307-314(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, TISSUE SPECIFICITY.
    3. "Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16."
      Daniels R.J., Peden J.F., Lloyd C., Horsley S.W., Clark K., Tufarelli C., Kearney L., Buckle V.J., Doggett N.A., Flint J., Higgs D.R.
      Hum. Mol. Genet. 10:339-352(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Embryo.
    6. "The sequence and analysis of duplication-rich human chromosome 16."
      Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J.
      , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A.
      Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
      Tissue: Blood and Lung.
    8. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
      Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
      Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-363, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    9. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    10. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-363, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    11. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-363, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    12. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    13. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-363, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiLUC7L_HUMAN
    AccessioniPrimary (citable) accession number: Q9NQ29
    Secondary accession number(s): B8ZZ13, Q96S32, Q9NPH4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 10, 2004
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 107 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 16
      Human chromosome 16: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3