Reviewed,
UniProtKB/Swiss-Prot Q9NQ29 (LUC7L_HUMAN)
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July 7, 2009.
Version 57.
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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Alternative products · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents
Names and origin
| Protein names | Recommended name: Putative RNA-binding protein Luc7-like 1 Alternative name(s): SR+89 Putative SR protein LUC7B1 | ||||
| Gene names |
| ||||
| Organism | Homo sapiens (Human) [Complete proteome] | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 371 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | May bind to RNA via its Arg/Ser-rich domain. Ref.2 |
| Tissue specificity | Ubiquitous. Ref.2 |
| Sequence similarities | Belongs to the Luc7 family. Contains 1 C2H2-type zinc finger. |
Ontologies
| Keywords | |
|---|---|
| Coding sequence diversity | Alternative splicing |
| Domain | Coiled coil Zinc-finger |
| Ligand | Metal-binding Zinc |
| PTM | Phosphoprotein |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Molecular function | zinc ion binding Inferred from electronic annotation. Source: UniProtKB-KW |
| Complete GO annotation... | |
Binary interactions
With | Entry | #Exp. | IntAct | Notes |
|---|---|---|---|---|
| NFKBIL1 | Q9UBC1 | 1 | EBI-473747,EBI-1043728 | |
| RNPS1 | Q15287 | 1 | EBI-473747,EBI-395959 |
Alternative products
| This entry describes 3 isoforms produced by alternative splicing. [Align] [Select] | ||||||
| Isoform 1 (identifier: Q9NQ29-1) This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. | ||||||
| Isoform 2 (identifier: Q9NQ29-2) The sequence of this isoform differs from the canonical sequence as follows: 326-371: Missing. | ||||||
| Note: May be due to an intron retention. | ||||||
| Isoform 3 (identifier: Q9NQ29-3) The sequence of this isoform differs from the canonical sequence as follows: 1-20: MSAQAQMRALLDQLMGTARD → MQM | ||||||
| Note: No experimental confirmation available. |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 371 | 371 | Putative RNA-binding protein Luc7-like 1 | PRO_0000187280 | |||||
Regions | |||||||||
| Zinc finger | 188 – 215 | 28 | C2H2-type; atypical | ||||||
| Coiled coil | 87 – 177 | 91 | Potential | ||||||
| Coiled coil | 218 – 259 | 42 | Potential | ||||||
| Compositional bias | 243 – 362 | 120 | Arg/Ser-rich | ||||||
Amino acid modifications | |||||||||
| Modified residue | 363 | 1 | Phosphoserine Ref.6 Ref.7 | ||||||
Natural variations | |||||||||
| Alternative sequence | 1 – 20 | 20 | MSAQA…GTARD → MQM in isoform 3. | VSP_010214 | |||||
| Alternative sequence | 326 – 371 | 46 | Missing in isoform 2. | VSP_010215 | |||||
Experimental info | |||||||||
| Sequence conflict | 171 | 1 | E → V in AAK61218. Ref.3 | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "SR+89, a gene encoding a serine/arginine-rich protein, is widely transcribed from human chromosome 16p13.3 proximal to the alpha-globin cluster. Exclusion of this new gene as a candidate gene for the hypospadic phenotype associated with homozygous SEA-alpha-thalassaemia." Utsch B., Albers N., Wickert L., Bidlingmaier F., Ludwig M. Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE (ISOFORM 2). |
| [2] | "Characterization of a widely expressed gene (LUC7-LIKE; LUC7L) defining the centromeric boundary of the human alpha-globin domain." Tufarelli C., Frischauf A.-M., Hardison R., Flint J., Higgs D.R. Genomics 71:307-314(2001) [PubMed: 11170747] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, TISSUE SPECIFICITY. |
| [3] | "Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16." Daniels R.J., Peden J.F., Lloyd C., Horsley S.W., Clark K., Tufarelli C., Kearney L., Buckle V.J., Doggett N.A., Flint J., Higgs D.R. Hum. Mol. Genet. 10:339-352(2001) [PubMed: 11157797] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| [4] | "Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. Sugano S.Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Embryo. |
| [5] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3). Tissue: Blood and Lung. |
| [6] | "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M. Cell 127:635-648(2006) [PubMed: 17081983] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-363, MASS SPECTROMETRY. Tissue: Epithelium. |
| [7] | "A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-363, MASS SPECTROMETRY. |
| [8] | Colinge J., Superti-Furga G., Bennett K.L. Submitted (OCT-2008) to UniProtKB Cited for: IDENTIFICATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY. |
Cross-references
Sequence databases | |
|---|---|
| AJ404326 mRNA. Translation: CAB93981.1. AJ404326 mRNA. Translation: CAB93982.1. AY005111 mRNA. Translation: AAG22846.1. AE006462 Genomic DNA. Translation: AAK61218.1. AK001093 mRNA. Translation: BAA91500.1. BC003194 mRNA. Translation: AAH03194.1. BC065198 mRNA. Translation: AAH65198.1. | |
| IPI | IPI00071318. IPI00410026. IPI00410027. |
| RefSeq | NP_060502.1. NP_958815.1. |
| UniGene | Hs.16803 |
3D structure databases | |
| ModBase | Search... |
Protein-protein interaction databases | |
| IntAct | Q9NQ29. 5 interactions. |
PTM databases | |
| PhosphoSite | Q9NQ29. |
Proteomic databases | |
| PRIDE | Q9NQ29. |
Genome annotation databases | |
| Ensembl | ENSG00000007392. Homo sapiens. [Contig view] |
| GeneID | 55692. |
| KEGG | hsa:55692. |
| UCSC | uc002cgc.1. human. |
Organism-specific databases | |
| GeneCards | GC16M000178. |
| HGNC | HGNC:6723. LUC7L. |
| MIM | 607782. gene. |
| PharmGKB | PA30485. |
| GenAtlas | Search... |
Phylogenomic databases | |
| HOGENOM | Q9NQ29. |
| HOVERGEN | Q9NQ29. |
| OMA | Q9NQ29. REESWEH. |
Gene expression databases | |
| ArrayExpress | Q9NQ29. |
| Bgee | Q9NQ29. |
| CleanEx | HS_LUC7L. |
| GermOnline | ENSG00000007392. Homo sapiens. |
Family and domain databases | |
| InterPro | IPR004882. LUC7_rel. [Graphical view] |
| PANTHER | PTHR12375. LUC7_rel. 1 hit. |
| Pfam | PF03194. LUC7. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 60505. |
| SOURCE | Search... |
Entry information
| Entry name | LUC7L_HUMAN | ||||||||
| Accession | Primary (citable) accession number: Q9NQ29 Secondary accession number(s): Q96S32, Q9NPH4 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| Human chromosome 16 Human chromosome 16: entries, gene names and cross-references to MIM |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

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