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Protein

Putative RNA-binding protein Luc7-like 1

Gene

LUC7L

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May bind to RNA via its Arg/Ser-rich domain.1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:ENSG00000007392-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative RNA-binding protein Luc7-like 1
Alternative name(s):
Putative SR protein LUC7B1
SR+89
Gene namesi
Name:LUC7L
Synonyms:LUC7L1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:6723. LUC7L.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

DisGeNETi55692.
OpenTargetsiENSG00000007392.
PharmGKBiPA30485.

Polymorphism and mutation databases

BioMutaiLUC7L.
DMDMi47116932.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001872801 – 371Putative RNA-binding protein Luc7-like 1Add BLAST371

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei332PhosphoserineCombined sources1
Modified residuei336PhosphoserineCombined sources1
Modified residuei363PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9NQ29.
MaxQBiQ9NQ29.
PaxDbiQ9NQ29.
PeptideAtlasiQ9NQ29.
PRIDEiQ9NQ29.

PTM databases

iPTMnetiQ9NQ29.
PhosphoSitePlusiQ9NQ29.

Expressioni

Tissue specificityi

Ubiquitous.1 Publication

Gene expression databases

BgeeiENSG00000007392.
CleanExiHS_LUC7L.
ExpressionAtlasiQ9NQ29. baseline and differential.
GenevisibleiQ9NQ29. HS.

Organism-specific databases

HPAiCAB033659.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
itself2EBI-473747,EBI-473747
CHERPQ8IWX82EBI-473747,EBI-2555370
SRPK1Q96SB42EBI-473747,EBI-539478
SRPK2P783622EBI-473747,EBI-593303

Protein-protein interaction databases

BioGridi120818. 117 interactors.
IntActiQ9NQ29. 19 interactors.
MINTiMINT-3071845.
STRINGi9606.ENSP00000293872.

Structurei

3D structure databases

ProteinModelPortaliQ9NQ29.
SMRiQ9NQ29.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili87 – 177Sequence analysisAdd BLAST91
Coiled coili218 – 259Sequence analysisAdd BLAST42

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi243 – 362Arg/Ser-richAdd BLAST120

Sequence similaritiesi

Belongs to the Luc7 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG0796. Eukaryota.
COG5200. LUCA.
GeneTreeiENSGT00730000110670.
HOGENOMiHOG000215956.
HOVERGENiHBG062167.
InParanoidiQ9NQ29.
OMAiHRHSHEQ.
OrthoDBiEOG091G0PSO.
PhylomeDBiQ9NQ29.
TreeFamiTF317607.

Family and domain databases

InterProiIPR004882. Luc7-rel.
[Graphical view]
PANTHERiPTHR12375. PTHR12375. 1 hit.
PfamiPF03194. LUC7. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9NQ29-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSAQAQMRAL LDQLMGTARD GDETRQRVKF TDDRVCKSHL LDCCPHDILA
60 70 80 90 100
GTRMDLGECT KIHDLALRAD YEIASKERDL FFELDAMDHL ESFIAECDRR
110 120 130 140 150
TELAKKRLAE TQEEISAEVS AKAEKVHELN EEIGKLLAKA EQLGAEGNVD
160 170 180 190 200
ESQKILMEVE KVRAKKKEAE EEYRNSMPAS SFQQQKLRVC EVCSAYLGLH
210 220 230 240 250
DNDRRLADHF GGKLHLGFIQ IREKLDQLRK TVAEKQEKRN QDRLRRREER
260 270 280 290 300
EREERLSRRS GSRTRDRRRS RSRDRRRRRS RSTSRERRKL SRSRSRDRHR
310 320 330 340 350
RHRSRSRSHS RGHRRASRDR SAKYKFSRER ASREESWESG RSERGPPDWR
360 370
LESSNGKMAS RRSEEKEAGE I
Length:371
Mass (Da):43,728
Last modified:October 1, 2000 - v1
Checksum:iC277F424F5F5659C
GO
Isoform 2 (identifier: Q9NQ29-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     326-371: Missing.

Note: May be due to an intron retention.
Show »
Length:325
Mass (Da):38,405
Checksum:i35D03C10999A44B6
GO
Isoform 3 (identifier: Q9NQ29-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-20: MSAQAQMRALLDQLMGTARD → MQM

Note: No experimental confirmation available.
Show »
Length:354
Mass (Da):41,929
Checksum:iB73044140DECCC9F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti171E → V in AAK61218 (PubMed:11157797).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0102141 – 20MSAQA…GTARD → MQM in isoform 3. 1 PublicationAdd BLAST20
Alternative sequenceiVSP_010215326 – 371Missing in isoform 2. 2 PublicationsAdd BLAST46

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ404326 mRNA. Translation: CAB93981.1.
AJ404326 mRNA. Translation: CAB93982.1.
AY005111 mRNA. Translation: AAG22846.1.
AE006462 Genomic DNA. Translation: AAK61218.1.
AK001093 mRNA. Translation: BAA91500.1.
Z69890, Z69706 Genomic DNA. Translation: CAM26671.1.
CH471112 Genomic DNA. Translation: EAW85853.1.
BC003194 mRNA. Translation: AAH03194.1.
BC065198 mRNA. Translation: AAH65198.1.
CCDSiCCDS10401.1. [Q9NQ29-2]
CCDS32348.1. [Q9NQ29-1]
RefSeqiNP_001307155.1. NM_001320226.1. [Q9NQ29-2]
NP_001317349.1. NM_001330420.1.
NP_060502.1. NM_018032.4. [Q9NQ29-2]
NP_958815.1. NM_201412.2. [Q9NQ29-1]
UniGeneiHs.16803.

Genome annotation databases

EnsembliENST00000293872; ENSP00000293872; ENSG00000007392. [Q9NQ29-1]
ENST00000337351; ENSP00000337507; ENSG00000007392. [Q9NQ29-2]
ENST00000397783; ENSP00000380885; ENSG00000007392. [Q9NQ29-2]
GeneIDi55692.
KEGGihsa:55692.
UCSCiuc002cga.2. human. [Q9NQ29-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ404326 mRNA. Translation: CAB93981.1.
AJ404326 mRNA. Translation: CAB93982.1.
AY005111 mRNA. Translation: AAG22846.1.
AE006462 Genomic DNA. Translation: AAK61218.1.
AK001093 mRNA. Translation: BAA91500.1.
Z69890, Z69706 Genomic DNA. Translation: CAM26671.1.
CH471112 Genomic DNA. Translation: EAW85853.1.
BC003194 mRNA. Translation: AAH03194.1.
BC065198 mRNA. Translation: AAH65198.1.
CCDSiCCDS10401.1. [Q9NQ29-2]
CCDS32348.1. [Q9NQ29-1]
RefSeqiNP_001307155.1. NM_001320226.1. [Q9NQ29-2]
NP_001317349.1. NM_001330420.1.
NP_060502.1. NM_018032.4. [Q9NQ29-2]
NP_958815.1. NM_201412.2. [Q9NQ29-1]
UniGeneiHs.16803.

3D structure databases

ProteinModelPortaliQ9NQ29.
SMRiQ9NQ29.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120818. 117 interactors.
IntActiQ9NQ29. 19 interactors.
MINTiMINT-3071845.
STRINGi9606.ENSP00000293872.

PTM databases

iPTMnetiQ9NQ29.
PhosphoSitePlusiQ9NQ29.

Polymorphism and mutation databases

BioMutaiLUC7L.
DMDMi47116932.

Proteomic databases

EPDiQ9NQ29.
MaxQBiQ9NQ29.
PaxDbiQ9NQ29.
PeptideAtlasiQ9NQ29.
PRIDEiQ9NQ29.

Protocols and materials databases

DNASUi55692.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000293872; ENSP00000293872; ENSG00000007392. [Q9NQ29-1]
ENST00000337351; ENSP00000337507; ENSG00000007392. [Q9NQ29-2]
ENST00000397783; ENSP00000380885; ENSG00000007392. [Q9NQ29-2]
GeneIDi55692.
KEGGihsa:55692.
UCSCiuc002cga.2. human. [Q9NQ29-1]

Organism-specific databases

CTDi55692.
DisGeNETi55692.
GeneCardsiLUC7L.
HGNCiHGNC:6723. LUC7L.
HPAiCAB033659.
MIMi607782. gene.
neXtProtiNX_Q9NQ29.
OpenTargetsiENSG00000007392.
PharmGKBiPA30485.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0796. Eukaryota.
COG5200. LUCA.
GeneTreeiENSGT00730000110670.
HOGENOMiHOG000215956.
HOVERGENiHBG062167.
InParanoidiQ9NQ29.
OMAiHRHSHEQ.
OrthoDBiEOG091G0PSO.
PhylomeDBiQ9NQ29.
TreeFamiTF317607.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000007392-MONOMER.

Miscellaneous databases

ChiTaRSiLUC7L. human.
GeneWikiiLUC7L.
GenomeRNAii55692.
PROiQ9NQ29.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000007392.
CleanExiHS_LUC7L.
ExpressionAtlasiQ9NQ29. baseline and differential.
GenevisibleiQ9NQ29. HS.

Family and domain databases

InterProiIPR004882. Luc7-rel.
[Graphical view]
PANTHERiPTHR12375. PTHR12375. 1 hit.
PfamiPF03194. LUC7. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLUC7L_HUMAN
AccessioniPrimary (citable) accession number: Q9NQ29
Secondary accession number(s): B8ZZ13, Q96S32, Q9NPH4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: October 1, 2000
Last modified: November 30, 2016
This is version 127 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.