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Q9NQ29

- LUC7L_HUMAN

UniProt

Q9NQ29 - LUC7L_HUMAN

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Protein
Putative RNA-binding protein Luc7-like 1
Gene
LUC7L, LUC7L1
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

May bind to RNA via its Arg/Ser-rich domain.1 Publication

GO - Molecular functioni

  1. identical protein binding Source: IntAct
  2. mRNA binding Source: InterPro
  3. protein binding Source: IntAct

GO - Biological processi

  1. mRNA splice site selection Source: InterPro
  2. negative regulation of striated muscle tissue development Source: Ensembl
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Putative RNA-binding protein Luc7-like 1
Alternative name(s):
Putative SR protein LUC7B1
SR+89
Gene namesi
Name:LUC7L
Synonyms:LUC7L1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 16

Organism-specific databases

HGNCiHGNC:6723. LUC7L.

Subcellular locationi

GO - Cellular componenti

  1. U1 snRNP Source: InterPro
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA30485.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 371371Putative RNA-binding protein Luc7-like 1
PRO_0000187280Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei363 – 3631Phosphoserine4 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9NQ29.
PaxDbiQ9NQ29.
PRIDEiQ9NQ29.

PTM databases

PhosphoSiteiQ9NQ29.

Expressioni

Tissue specificityi

Ubiquitous.1 Publication

Gene expression databases

ArrayExpressiQ9NQ29.
BgeeiQ9NQ29.
CleanExiHS_LUC7L.
GenevestigatoriQ9NQ29.

Organism-specific databases

HPAiCAB033659.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
itself2EBI-473747,EBI-473747
CHERPQ8IWX82EBI-473747,EBI-2555370
SRPK1Q96SB42EBI-473747,EBI-539478
SRPK2P783622EBI-473747,EBI-593303

Protein-protein interaction databases

BioGridi120818. 22 interactions.
IntActiQ9NQ29. 14 interactions.
MINTiMINT-3071845.
STRINGi9606.ENSP00000293872.

Structurei

3D structure databases

ProteinModelPortaliQ9NQ29.

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili87 – 17791 Reviewed prediction
Add
BLAST
Coiled coili218 – 25942 Reviewed prediction
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi243 – 362120Arg/Ser-rich
Add
BLAST

Sequence similaritiesi

Belongs to the Luc7 family.

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiCOG5200.
HOGENOMiHOG000215956.
HOVERGENiHBG062167.
InParanoidiQ9NQ29.
OMAiRHESTNG.
PhylomeDBiQ9NQ29.
TreeFamiTF317607.

Family and domain databases

InterProiIPR004882. Luc7-rel.
[Graphical view]
PANTHERiPTHR12375. PTHR12375. 1 hit.
PfamiPF03194. LUC7. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9NQ29-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MSAQAQMRAL LDQLMGTARD GDETRQRVKF TDDRVCKSHL LDCCPHDILA    50
GTRMDLGECT KIHDLALRAD YEIASKERDL FFELDAMDHL ESFIAECDRR 100
TELAKKRLAE TQEEISAEVS AKAEKVHELN EEIGKLLAKA EQLGAEGNVD 150
ESQKILMEVE KVRAKKKEAE EEYRNSMPAS SFQQQKLRVC EVCSAYLGLH 200
DNDRRLADHF GGKLHLGFIQ IREKLDQLRK TVAEKQEKRN QDRLRRREER 250
EREERLSRRS GSRTRDRRRS RSRDRRRRRS RSTSRERRKL SRSRSRDRHR 300
RHRSRSRSHS RGHRRASRDR SAKYKFSRER ASREESWESG RSERGPPDWR 350
LESSNGKMAS RRSEEKEAGE I 371
Length:371
Mass (Da):43,728
Last modified:October 1, 2000 - v1
Checksum:iC277F424F5F5659C
GO
Isoform 2 (identifier: Q9NQ29-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     326-371: Missing.

Note: May be due to an intron retention.

Show »
Length:325
Mass (Da):38,405
Checksum:i35D03C10999A44B6
GO
Isoform 3 (identifier: Q9NQ29-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-20: MSAQAQMRALLDQLMGTARD → MQM

Note: No experimental confirmation available.

Show »
Length:354
Mass (Da):41,929
Checksum:iB73044140DECCC9F
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 2020MSAQA…GTARD → MQM in isoform 3.
VSP_010214Add
BLAST
Alternative sequencei326 – 37146Missing in isoform 2.
VSP_010215Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti171 – 1711E → V in AAK61218. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ404326 mRNA. Translation: CAB93981.1.
AJ404326 mRNA. Translation: CAB93982.1.
AY005111 mRNA. Translation: AAG22846.1.
AE006462 Genomic DNA. Translation: AAK61218.1.
AK001093 mRNA. Translation: BAA91500.1.
Z69890, Z69706 Genomic DNA. Translation: CAM26671.1.
CH471112 Genomic DNA. Translation: EAW85853.1.
BC003194 mRNA. Translation: AAH03194.1.
BC065198 mRNA. Translation: AAH65198.1.
CCDSiCCDS10401.1. [Q9NQ29-2]
CCDS32348.1. [Q9NQ29-1]
RefSeqiNP_060502.1. NM_018032.3. [Q9NQ29-2]
NP_958815.1. NM_201412.1. [Q9NQ29-1]
XP_005255483.1. XM_005255426.1. [Q9NQ29-2]
UniGeneiHs.16803.

Genome annotation databases

EnsembliENST00000293872; ENSP00000293872; ENSG00000007392. [Q9NQ29-1]
ENST00000337351; ENSP00000337507; ENSG00000007392. [Q9NQ29-2]
ENST00000397783; ENSP00000380885; ENSG00000007392. [Q9NQ29-2]
GeneIDi55692.
KEGGihsa:55692.
UCSCiuc002cga.1. human. [Q9NQ29-1]

Polymorphism databases

DMDMi47116932.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ404326 mRNA. Translation: CAB93981.1 .
AJ404326 mRNA. Translation: CAB93982.1 .
AY005111 mRNA. Translation: AAG22846.1 .
AE006462 Genomic DNA. Translation: AAK61218.1 .
AK001093 mRNA. Translation: BAA91500.1 .
Z69890 , Z69706 Genomic DNA. Translation: CAM26671.1 .
CH471112 Genomic DNA. Translation: EAW85853.1 .
BC003194 mRNA. Translation: AAH03194.1 .
BC065198 mRNA. Translation: AAH65198.1 .
CCDSi CCDS10401.1. [Q9NQ29-2 ]
CCDS32348.1. [Q9NQ29-1 ]
RefSeqi NP_060502.1. NM_018032.3. [Q9NQ29-2 ]
NP_958815.1. NM_201412.1. [Q9NQ29-1 ]
XP_005255483.1. XM_005255426.1. [Q9NQ29-2 ]
UniGenei Hs.16803.

3D structure databases

ProteinModelPortali Q9NQ29.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 120818. 22 interactions.
IntActi Q9NQ29. 14 interactions.
MINTi MINT-3071845.
STRINGi 9606.ENSP00000293872.

PTM databases

PhosphoSitei Q9NQ29.

Polymorphism databases

DMDMi 47116932.

Proteomic databases

MaxQBi Q9NQ29.
PaxDbi Q9NQ29.
PRIDEi Q9NQ29.

Protocols and materials databases

DNASUi 55692.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000293872 ; ENSP00000293872 ; ENSG00000007392 . [Q9NQ29-1 ]
ENST00000337351 ; ENSP00000337507 ; ENSG00000007392 . [Q9NQ29-2 ]
ENST00000397783 ; ENSP00000380885 ; ENSG00000007392 . [Q9NQ29-2 ]
GeneIDi 55692.
KEGGi hsa:55692.
UCSCi uc002cga.1. human. [Q9NQ29-1 ]

Organism-specific databases

CTDi 55692.
GeneCardsi GC16M000238.
HGNCi HGNC:6723. LUC7L.
HPAi CAB033659.
MIMi 607782. gene.
neXtProti NX_Q9NQ29.
PharmGKBi PA30485.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5200.
HOGENOMi HOG000215956.
HOVERGENi HBG062167.
InParanoidi Q9NQ29.
OMAi RHESTNG.
PhylomeDBi Q9NQ29.
TreeFami TF317607.

Miscellaneous databases

ChiTaRSi LUC7L. human.
GeneWikii LUC7L.
GenomeRNAii 55692.
NextBioi 60505.
PROi Q9NQ29.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9NQ29.
Bgeei Q9NQ29.
CleanExi HS_LUC7L.
Genevestigatori Q9NQ29.

Family and domain databases

InterProi IPR004882. Luc7-rel.
[Graphical view ]
PANTHERi PTHR12375. PTHR12375. 1 hit.
Pfami PF03194. LUC7. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "SR+89, a gene encoding a serine/arginine-rich protein, is widely transcribed from human chromosome 16p13.3 proximal to the alpha-globin cluster. Exclusion of this new gene as a candidate gene for the hypospadic phenotype associated with homozygous SEA-alpha-thalassaemia."
    Utsch B., Albers N., Wickert L., Bidlingmaier F., Ludwig M.
    Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE (ISOFORM 2).
  2. "Characterization of a widely expressed gene (LUC7-LIKE; LUC7L) defining the centromeric boundary of the human alpha-globin domain."
    Tufarelli C., Frischauf A.-M., Hardison R., Flint J., Higgs D.R.
    Genomics 71:307-314(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, TISSUE SPECIFICITY.
  3. "Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16."
    Daniels R.J., Peden J.F., Lloyd C., Horsley S.W., Clark K., Tufarelli C., Kearney L., Buckle V.J., Doggett N.A., Flint J., Higgs D.R.
    Hum. Mol. Genet. 10:339-352(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Embryo.
  6. "The sequence and analysis of duplication-rich human chromosome 16."
    Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J.
    , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A.
    Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
    Tissue: Blood and Lung.
  8. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
    Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
    Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-363, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  9. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  10. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-363, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  11. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-363, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  12. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  13. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-363, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiLUC7L_HUMAN
AccessioniPrimary (citable) accession number: Q9NQ29
Secondary accession number(s): B8ZZ13, Q96S32, Q9NPH4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: October 1, 2000
Last modified: July 9, 2014
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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