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Q9NQ25

- SLAF7_HUMAN

UniProt

Q9NQ25 - SLAF7_HUMAN

Protein

SLAM family member 7

Gene

SLAMF7

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
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    • History
      Entry version 119 (01 Oct 2014)
      Sequence version 1 (01 Oct 2000)
      Previous versions | rss
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    Functioni

    Isoform 1 mediates NK cell activation through a SH2D1A-independent extracellular signal-regulated ERK-mediated pathway. May play a role in lymphocyte adhesion.
    Isoform 3 does not mediate any NK cell activation.

    GO - Molecular functioni

    1. receptor activity Source: InterPro

    GO - Biological processi

    1. cell adhesion Source: UniProtKB
    2. natural killer cell activation Source: UniProtKB
    3. natural killer cell mediated cytotoxicity Source: UniProtKB
    4. regulation of natural killer cell activation Source: Ensembl

    Keywords - Molecular functioni

    Receptor

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    SLAM family member 7
    Alternative name(s):
    CD2 subset 1
    CD2-like receptor-activating cytotoxic cells
    Short name:
    CRACC
    Membrane protein FOAP-12
    Novel Ly9
    Protein 19A
    CD_antigen: CD319
    Gene namesi
    Name:SLAMF7
    Synonyms:CS1
    ORF Names:UNQ576/PRO1138
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:21394. SLAMF7.

    Subcellular locationi

    GO - Cellular componenti

    1. external side of plasma membrane Source: Ensembl
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134977110.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 22221 PublicationAdd
    BLAST
    Chaini23 – 335313SLAM family member 7PRO_0000014963Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi98 – 981N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi142 – 1421N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi145 ↔ 215PROSITE-ProRule annotation
    Glycosylationi148 – 1481N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi151 ↔ 195PROSITE-ProRule annotation
    Glycosylationi172 – 1721N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi176 – 1761N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi204 – 2041N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    MaxQBiQ9NQ25.
    PaxDbiQ9NQ25.
    PRIDEiQ9NQ25.

    PTM databases

    PhosphoSiteiQ9NQ25.

    Expressioni

    Tissue specificityi

    Expressed in spleen, lymph node, peripheral blood leukocytes, bone marrow, small intestine, stomach, appendix, lung and trachea. Expression was detected in NK cells, activated B-cells, NK-cell line but not in promyelocytic, B-, or T-cell lines. Isoform 3 is expressed at much lower level than isoform 1.4 Publications

    Gene expression databases

    ArrayExpressiQ9NQ25.
    BgeeiQ9NQ25.
    CleanExiHS_SLAMF7.
    GenevestigatoriQ9NQ25.

    Organism-specific databases

    HPAiCAB015445.

    Interactioni

    Subunit structurei

    Isoform 1 binds to SH2D1A when its cytoplasmic tail is phosphorylated in the presence of FYN (in vitro).1 Publication

    Protein-protein interaction databases

    BioGridi121782. 4 interactions.
    IntActiQ9NQ25. 3 interactions.
    MINTiMINT-4722730.
    STRINGi9606.ENSP00000357022.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9NQ25.
    SMRiQ9NQ25. Positions 31-216.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini23 – 226204ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini248 – 33588CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei227 – 24721HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini23 – 124102Ig-like V-typeAdd
    BLAST
    Domaini131 – 20676Ig-like C2-typeAdd
    BLAST

    Sequence similaritiesi

    Keywords - Domaini

    Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG272174.
    HOGENOMiHOG000013065.
    HOVERGENiHBG079189.
    InParanoidiQ9NQ25.
    KOiK06733.
    OMAiEDVTYSW.
    OrthoDBiEOG77HDFC.
    PhylomeDBiQ9NQ25.
    TreeFamiTF334964.

    Family and domain databases

    Gene3Di2.60.40.10. 1 hit.
    InterProiIPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003599. Ig_sub.
    IPR013106. Ig_V-set.
    IPR015631. SLAM_fam_rcpts.
    [Graphical view]
    PANTHERiPTHR12080. PTHR12080. 1 hit.
    PfamiPF07686. V-set. 1 hit.
    [Graphical view]
    SMARTiSM00409. IG. 1 hit.
    [Graphical view]
    PROSITEiPS50835. IG_LIKE. 1 hit.
    [Graphical view]

    Sequences (7)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 7 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9NQ25-1) [UniParc]FASTAAdd to Basket

    Also known as: 19A, CS1-L

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAGSPTCLTL IYILWQLTGS AASGPVKELV GSVGGAVTFP LKSKVKQVDS    50
    IVWTFNTTPL VTIQPEGGTI IVTQNRNRER VDFPDGGYSL KLSKLKKNDS 100
    GIYYVGIYSS SLQQPSTQEY VLHVYEHLSK PKVTMGLQSN KNGTCVTNLT 150
    CCMEHGEEDV IYTWKALGQA ANESHNGSIL PISWRWGESD MTFICVARNP 200
    VSRNFSSPIL ARKLCEGAAD DPDSSMVLLC LLLVPLLLSL FVLGLFLWFL 250
    KRERQEEYIE EKKRVDICRE TPNICPHSGE NTEYDTIPHT NRTILKEDPA 300
    NTVYSTVEIP KKMENPHSLL TMPDTPRLFA YENVI 335
    Length:335
    Mass (Da):37,421
    Last modified:October 1, 2000 - v1
    Checksum:iD09ABBCFF74BE8D4
    GO
    Isoform 2 (identifier: Q9NQ25-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         19-125: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:228
    Mass (Da):25,831
    Checksum:i2B01DB70E7BBFC14
    GO
    Isoform 3 (identifier: Q9NQ25-3) [UniParc]FASTAAdd to Basket

    Also known as: 19A24, CS1-S

    The sequence of this isoform differs from the canonical sequence as follows:
         258-296: YIEEKKRVDI...IPHTNRTILK → NNPKGRSSKY...DARHTKAICL

    Show »
    Length:335
    Mass (Da):37,026
    Checksum:i3CD49C30FF3367B0
    GO
    Isoform 4 (identifier: Q9NQ25-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         127-165: HLSKPKVTMG...GEEDVIYTWK → NNPKGRSSKY...DARHTKAICL
         166-335: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:165
    Mass (Da):17,945
    Checksum:iE70079B2E27C5978
    GO
    Isoform 5 (identifier: Q9NQ25-5) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         258-335: YIEEKKRVDI...PRLFAYENVI → NNPKGRSSKY...DARHTKAICL

    Note: No experimental confirmation available.

    Show »
    Length:296
    Mass (Da):32,581
    Checksum:iE85D277192494EEC
    GO
    Isoform 6 (identifier: Q9NQ25-6) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         126-256: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:204
    Mass (Da):22,785
    Checksum:iE7DEE14130014CD5
    GO
    Isoform 7 (identifier: Q9NQ25-7) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         19-125: Missing.
         217-256: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:188
    Mass (Da):21,316
    Checksum:i76BA8CF2C70B4663
    GO

    Sequence cautioni

    The sequence CAB76561.1 differs from that shown. Reason: Frameshift at several positions.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti135 – 1351M → L in CAB81950. (PubMed:11802771)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti175 – 1751H → Y.
    Corresponds to variant rs35325048 [ dbSNP | Ensembl ].
    VAR_049938
    Natural varianti302 – 3021T → M.
    Corresponds to variant rs2295617 [ dbSNP | Ensembl ].
    VAR_049939

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei19 – 125107Missing in isoform 2 and isoform 7. 2 PublicationsVSP_013781Add
    BLAST
    Alternative sequencei126 – 256131Missing in isoform 6. 1 PublicationVSP_055292Add
    BLAST
    Alternative sequencei127 – 16539HLSKP…IYTWK → NNPKGRSSKYGLLHCGNTEK DGKSPLTAHDARHTKAICL in isoform 4. 1 PublicationVSP_054540Add
    BLAST
    Alternative sequencei166 – 335170Missing in isoform 4. 1 PublicationVSP_054541Add
    BLAST
    Alternative sequencei217 – 25640Missing in isoform 7. 1 PublicationVSP_055293Add
    BLAST
    Alternative sequencei258 – 33578YIEEK…YENVI → NNPKGRSSKYGLLHCGNTEK DGKSPLTAHDARHTKAICL in isoform 5. CuratedVSP_054542Add
    BLAST
    Alternative sequencei258 – 29639YIEEK…RTILK → NNPKGRSSKYGLLHCGNTEK DGKSPLTAHDARHTKAICL in isoform 3. 2 PublicationsVSP_013782Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF291815 mRNA. Translation: AAK11549.1.
    AF390894 mRNA. Translation: AAL26989.1.
    AJ271869 mRNA. Translation: CAB76561.1. Frameshift.
    AJ276429 mRNA. Translation: CAB81950.2.
    AB027233 mRNA. Translation: BAB61022.1.
    AY358512 mRNA. Translation: AAQ88876.1.
    AK290706 mRNA. Translation: BAF83395.1.
    AK298499 mRNA. Translation: BAG60706.1.
    AK298548 mRNA. Translation: BAG60745.1.
    AK301438 mRNA. Translation: BAG62965.1.
    AL834424 mRNA. Translation: CAD39085.1.
    AL121985 Genomic DNA. Translation: CAC00579.1.
    AL121985 Genomic DNA. Translation: CAH73507.1.
    AL121985 Genomic DNA. Translation: CAH73508.1.
    CH471121 Genomic DNA. Translation: EAW52704.1.
    BC027867 mRNA. Translation: AAH27867.1.
    CCDSiCCDS1209.1. [Q9NQ25-1]
    CCDS60321.1. [Q9NQ25-5]
    CCDS60322.1. [Q9NQ25-6]
    CCDS60323.1. [Q9NQ25-4]
    CCDS60324.1. [Q9NQ25-2]
    CCDS60325.1. [Q9NQ25-7]
    RefSeqiNP_001269517.1. NM_001282588.1. [Q9NQ25-4]
    NP_001269518.1. NM_001282589.1.
    NP_001269519.1. NM_001282590.1. [Q9NQ25-2]
    NP_001269520.1. NM_001282591.1.
    NP_001269521.1. NM_001282592.1. [Q9NQ25-5]
    NP_001269524.1. NM_001282595.1.
    NP_067004.3. NM_021181.4. [Q9NQ25-1]
    UniGeneiHs.517265.

    Genome annotation databases

    EnsembliENST00000359331; ENSP00000352281; ENSG00000026751. [Q9NQ25-5]
    ENST00000368042; ENSP00000357021; ENSG00000026751. [Q9NQ25-2]
    ENST00000368043; ENSP00000357022; ENSG00000026751. [Q9NQ25-1]
    ENST00000441662; ENSP00000405605; ENSG00000026751. [Q9NQ25-6]
    ENST00000444090; ENSP00000416592; ENSG00000026751. [Q9NQ25-4]
    ENST00000458602; ENSP00000409965; ENSG00000026751. [Q9NQ25-7]
    GeneIDi57823.
    KEGGihsa:57823.
    UCSCiuc001fwq.3. human. [Q9NQ25-1]
    uc001fwr.3. human.
    uc001fws.3. human. [Q9NQ25-2]

    Polymorphism databases

    DMDMi66774034.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF291815 mRNA. Translation: AAK11549.1 .
    AF390894 mRNA. Translation: AAL26989.1 .
    AJ271869 mRNA. Translation: CAB76561.1 . Frameshift.
    AJ276429 mRNA. Translation: CAB81950.2 .
    AB027233 mRNA. Translation: BAB61022.1 .
    AY358512 mRNA. Translation: AAQ88876.1 .
    AK290706 mRNA. Translation: BAF83395.1 .
    AK298499 mRNA. Translation: BAG60706.1 .
    AK298548 mRNA. Translation: BAG60745.1 .
    AK301438 mRNA. Translation: BAG62965.1 .
    AL834424 mRNA. Translation: CAD39085.1 .
    AL121985 Genomic DNA. Translation: CAC00579.1 .
    AL121985 Genomic DNA. Translation: CAH73507.1 .
    AL121985 Genomic DNA. Translation: CAH73508.1 .
    CH471121 Genomic DNA. Translation: EAW52704.1 .
    BC027867 mRNA. Translation: AAH27867.1 .
    CCDSi CCDS1209.1. [Q9NQ25-1 ]
    CCDS60321.1. [Q9NQ25-5 ]
    CCDS60322.1. [Q9NQ25-6 ]
    CCDS60323.1. [Q9NQ25-4 ]
    CCDS60324.1. [Q9NQ25-2 ]
    CCDS60325.1. [Q9NQ25-7 ]
    RefSeqi NP_001269517.1. NM_001282588.1. [Q9NQ25-4 ]
    NP_001269518.1. NM_001282589.1.
    NP_001269519.1. NM_001282590.1. [Q9NQ25-2 ]
    NP_001269520.1. NM_001282591.1.
    NP_001269521.1. NM_001282592.1. [Q9NQ25-5 ]
    NP_001269524.1. NM_001282595.1.
    NP_067004.3. NM_021181.4. [Q9NQ25-1 ]
    UniGenei Hs.517265.

    3D structure databases

    ProteinModelPortali Q9NQ25.
    SMRi Q9NQ25. Positions 31-216.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 121782. 4 interactions.
    IntActi Q9NQ25. 3 interactions.
    MINTi MINT-4722730.
    STRINGi 9606.ENSP00000357022.

    PTM databases

    PhosphoSitei Q9NQ25.

    Polymorphism databases

    DMDMi 66774034.

    Proteomic databases

    MaxQBi Q9NQ25.
    PaxDbi Q9NQ25.
    PRIDEi Q9NQ25.

    Protocols and materials databases

    DNASUi 57823.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000359331 ; ENSP00000352281 ; ENSG00000026751 . [Q9NQ25-5 ]
    ENST00000368042 ; ENSP00000357021 ; ENSG00000026751 . [Q9NQ25-2 ]
    ENST00000368043 ; ENSP00000357022 ; ENSG00000026751 . [Q9NQ25-1 ]
    ENST00000441662 ; ENSP00000405605 ; ENSG00000026751 . [Q9NQ25-6 ]
    ENST00000444090 ; ENSP00000416592 ; ENSG00000026751 . [Q9NQ25-4 ]
    ENST00000458602 ; ENSP00000409965 ; ENSG00000026751 . [Q9NQ25-7 ]
    GeneIDi 57823.
    KEGGi hsa:57823.
    UCSCi uc001fwq.3. human. [Q9NQ25-1 ]
    uc001fwr.3. human.
    uc001fws.3. human. [Q9NQ25-2 ]

    Organism-specific databases

    CTDi 57823.
    GeneCardsi GC01P160709.
    HGNCi HGNC:21394. SLAMF7.
    HPAi CAB015445.
    MIMi 606625. gene.
    neXtProti NX_Q9NQ25.
    PharmGKBi PA134977110.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG272174.
    HOGENOMi HOG000013065.
    HOVERGENi HBG079189.
    InParanoidi Q9NQ25.
    KOi K06733.
    OMAi EDVTYSW.
    OrthoDBi EOG77HDFC.
    PhylomeDBi Q9NQ25.
    TreeFami TF334964.

    Miscellaneous databases

    GeneWikii SLAMF7.
    GenomeRNAii 57823.
    NextBioi 35464059.
    PROi Q9NQ25.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9NQ25.
    Bgeei Q9NQ25.
    CleanExi HS_SLAMF7.
    Genevestigatori Q9NQ25.

    Family and domain databases

    Gene3Di 2.60.40.10. 1 hit.
    InterProi IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003599. Ig_sub.
    IPR013106. Ig_V-set.
    IPR015631. SLAM_fam_rcpts.
    [Graphical view ]
    PANTHERi PTHR12080. PTHR12080. 1 hit.
    Pfami PF07686. V-set. 1 hit.
    [Graphical view ]
    SMARTi SM00409. IG. 1 hit.
    [Graphical view ]
    PROSITEi PS50835. IG_LIKE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning of CS1, a novel human natural killer cell receptor belonging to the CD2 subset of the immunoglobulin superfamily."
      Boles K.S., Mathew P.A.
      Immunogenetics 52:302-307(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
    2. "Activation of NK cell-mediated cytotoxicity by a SAP-independent receptor of the CD2 family."
      Bouchon A., Cella M., Grierson H.L., Cohen J.I., Colonna M.
      J. Immunol. 167:5517-5521(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, TISSUE SPECIFICITY.
    3. "A novel immunoglobulin superfamily receptor (19A) related to CD2 is expressed on activated lymphocytes and promotes homotypic B-cell adhesion."
      Murphy J.J., Hobby P., Vilarino-Varela J., Bishop B., Iordanidou P., Sutton B.J., Norton J.D.
      Biochem. J. 361:431-436(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 3), FUNCTION, TISSUE SPECIFICITY.
    4. "Homo sapiens mRNA for FOAP-12 protein, complete cds."
      Fujii Y., Takayama K., Tsuritani K., Yajima Y., Amemiya T., Ukai Y., Naito K., Kawaguchi A.
      Submitted (MAY-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Macrophage.
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    6. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 4; 6 AND 7).
      Tissue: Lung and Synovium.
    7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Lymph node.
    8. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    9. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    10. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
      Tissue: Fetal lung and Fetal spleen.
    11. "Signal peptide prediction based on analysis of experimentally verified cleavage sites."
      Zhang Z., Henzel W.J.
      Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 23-37.
    12. "Molecular and functional characterization of a CS1 (CRACC) splice variant expressed in human NK cells that does not contain immunoreceptor tyrosine-based switch motifs."
      Lee J.K., Boles K.S., Mathew P.A.
      Eur. J. Immunol. 34:2791-2799(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: ALTERNATIVE SPLICING (ISOFORM 3).
    13. "Mouse novel Ly9: a new member of the expanding CD150 (SLAM) family of leukocyte cell-surface receptors."
      Tovar V., Del Valle J., Zapater N., Martin M., Romero X., Pizcueta P., Bosch J., Terhorst C., Engel P.
      Immunogenetics 54:394-402(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY, INTERACTION WITH SH2D1A.

    Entry informationi

    Entry nameiSLAF7_HUMAN
    AccessioniPrimary (citable) accession number: Q9NQ25
    Secondary accession number(s): A8K3U1
    , B4DPU4, B4DPY3, B4DWA3, Q8N6Y8, Q8ND32, Q9NY08, Q9NY23
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 24, 2005
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 119 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human cell differentiation molecules
      CD nomenclature of surface proteins of human leucocytes and list of entries
    2. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3