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Protein

SLAM family member 7

Gene

SLAMF7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2. Isoform 1 mediates NK cell activation through a SH2D1A-independent extracellular signal-regulated ERK-mediated pathway (PubMed:11698418). Positively regulates NK cell functions by a mechanism dependent on phosphorylated SH2D1B. Downstream signaling implicates PLCG1, PLCG2 and PI3K (PubMed:16339536). In addition to heterotypic NK cells-target cells interactions also homotypic interactions between NK cells may contribute to activation. However, in the absence of SH2D1B, inhibits NK cell function. Acts also inhibitory in T-cells (By similarity). May play a role in lymphocyte adhesion (PubMed:11802771). In LPS-activated monocytes negatively regulates production of proinflammatory cytokines (PubMed:23695528).By similarity5 Publications
Isoform 3 does not mediate any NK cell activation.

GO - Biological processi

  • adaptive immune response Source: UniProtKB-KW
  • cell adhesion Source: UniProtKB
  • natural killer cell activation Source: UniProtKB
  • natural killer cell mediated cytotoxicity Source: UniProtKB
  • regulation of immune response Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Adaptive immunity, Immunity, Innate immunity

Enzyme and pathway databases

ReactomeiR-HSA-198933. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.

Names & Taxonomyi

Protein namesi
Recommended name:
SLAM family member 7
Alternative name(s):
CD2 subset 1
CD2-like receptor-activating cytotoxic cells
Short name:
CRACC
Membrane protein FOAP-12
Novel Ly9
Protein 19A
CD_antigen: CD319
Gene namesi
Name:SLAMF7
Synonyms:CS1
ORF Names:UNQ576/PRO1138
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:21394. SLAMF7.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini23 – 226204ExtracellularSequence analysisAdd
BLAST
Transmembranei227 – 24721HelicalSequence analysisAdd
BLAST
Topological domaini248 – 33588CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134977110.

Chemistry

ChEMBLiCHEMBL3559386.
DrugBankiDB06317. Elotuzumab.
GuidetoPHARMACOLOGYi2850.

Polymorphism and mutation databases

DMDMi66774034.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 22221 PublicationAdd
BLAST
Chaini23 – 335313SLAM family member 7PRO_0000014963Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi98 – 981N-linked (GlcNAc...)Sequence analysis
Glycosylationi142 – 1421N-linked (GlcNAc...)Sequence analysis
Disulfide bondi145 ↔ 215PROSITE-ProRule annotation
Glycosylationi148 – 1481N-linked (GlcNAc...)Sequence analysis
Disulfide bondi151 ↔ 195PROSITE-ProRule annotation
Glycosylationi172 – 1721N-linked (GlcNAc...)Sequence analysis
Glycosylationi176 – 1761N-linked (GlcNAc...)Sequence analysis
Glycosylationi204 – 2041N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ9NQ25.
PaxDbiQ9NQ25.
PeptideAtlasiQ9NQ25.
PRIDEiQ9NQ25.
TopDownProteomicsiQ9NQ25-2. [Q9NQ25-2]

PTM databases

iPTMnetiQ9NQ25.
PhosphoSiteiQ9NQ25.

Expressioni

Tissue specificityi

Expressed in spleen, lymph node, peripheral blood leukocytes, bone marrow, small intestine, stomach, appendix, lung and trachea. Expression was detected in NK cells, activated B-cells, NK-cell line but not in promyelocytic, B-, or T-cell lines. Expressed in monocytes. Isoform 3 is expressed at much lower level than isoform 1.5 Publications

Gene expression databases

BgeeiENSG00000026751.
CleanExiHS_SLAMF7.
ExpressionAtlasiQ9NQ25. baseline and differential.
GenevisibleiQ9NQ25. HS.

Organism-specific databases

HPAiCAB015445.
HPA055945.

Interactioni

Subunit structurei

Isoform 1 binds to SH2D1A when its cytoplasmic tail is phosphorylated in the presence of FYN (in vitro); low affinity binding, the physiological relevance of the interaction is questioned. Interacts with SH2D1B; in NK cells (PubMed:16339536). Interacts (via ITSM phosphorylated on Tyr-302) with SH2D1B, PTPN6/SHP-1, PTPN11/SHP-2, INPP5D/SHIP1, CSK and FYN (By similarity).By similarity2 Publications

Protein-protein interaction databases

BioGridi121782. 16 interactions.
IntActiQ9NQ25. 5 interactions.
MINTiMINT-4722730.
STRINGi9606.ENSP00000357022.

Structurei

3D structure databases

ProteinModelPortaliQ9NQ25.
SMRiQ9NQ25. Positions 31-216.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini23 – 124102Ig-like V-typeAdd
BLAST
Domaini131 – 20676Ig-like C2-typeAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni278 – 29619Interaction with FYN when phosphorylated at Tyr-284By similarityAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi302 – 3076ITSMBy similarity

Domaini

The ITSMs (immunoreceptor tyrosine-based switch motifs) with the consensus sequence T-X-Y-X-X-[VI] present in SLAM family receptors have overlapping specificity for activating and inhibitory SH2 domain-containing binding partners. Especially they mediate the interaction with the SH2 domain of SH2D1A and SH2D1B. A 'three-pronged' mechanism is proposed involving threonine (position -2), phosphorylated tyrosine (position 0) and valine/isoleucine (position +3).By similarity

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IJW6. Eukaryota.
ENOG41117FX. LUCA.
GeneTreeiENSGT00530000063114.
HOGENOMiHOG000013065.
HOVERGENiHBG079189.
InParanoidiQ9NQ25.
KOiK06733.
OMAiCPHSGEN.
OrthoDBiEOG091G0KKU.
PhylomeDBiQ9NQ25.
TreeFamiTF334964.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF07686. V-set. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 2 hits.
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]

Sequences (7)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 7 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9NQ25-1) [UniParc]FASTAAdd to basket
Also known as: 19A, CS1-L

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAGSPTCLTL IYILWQLTGS AASGPVKELV GSVGGAVTFP LKSKVKQVDS
60 70 80 90 100
IVWTFNTTPL VTIQPEGGTI IVTQNRNRER VDFPDGGYSL KLSKLKKNDS
110 120 130 140 150
GIYYVGIYSS SLQQPSTQEY VLHVYEHLSK PKVTMGLQSN KNGTCVTNLT
160 170 180 190 200
CCMEHGEEDV IYTWKALGQA ANESHNGSIL PISWRWGESD MTFICVARNP
210 220 230 240 250
VSRNFSSPIL ARKLCEGAAD DPDSSMVLLC LLLVPLLLSL FVLGLFLWFL
260 270 280 290 300
KRERQEEYIE EKKRVDICRE TPNICPHSGE NTEYDTIPHT NRTILKEDPA
310 320 330
NTVYSTVEIP KKMENPHSLL TMPDTPRLFA YENVI
Length:335
Mass (Da):37,421
Last modified:October 1, 2000 - v1
Checksum:iD09ABBCFF74BE8D4
GO
Isoform 2 (identifier: Q9NQ25-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     19-125: Missing.

Note: No experimental confirmation available.
Show »
Length:228
Mass (Da):25,831
Checksum:i2B01DB70E7BBFC14
GO
Isoform 3 (identifier: Q9NQ25-3) [UniParc]FASTAAdd to basket
Also known as: 19A24, CS1-S

The sequence of this isoform differs from the canonical sequence as follows:
     258-296: YIEEKKRVDI...IPHTNRTILK → NNPKGRSSKY...DARHTKAICL

Show »
Length:335
Mass (Da):37,026
Checksum:i3CD49C30FF3367B0
GO
Isoform 4 (identifier: Q9NQ25-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     127-165: HLSKPKVTMG...GEEDVIYTWK → NNPKGRSSKY...DARHTKAICL
     166-335: Missing.

Note: No experimental confirmation available.
Show »
Length:165
Mass (Da):17,945
Checksum:iE70079B2E27C5978
GO
Isoform 5 (identifier: Q9NQ25-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     258-335: YIEEKKRVDI...PRLFAYENVI → NNPKGRSSKY...DARHTKAICL

Note: No experimental confirmation available.
Show »
Length:296
Mass (Da):32,581
Checksum:iE85D277192494EEC
GO
Isoform 6 (identifier: Q9NQ25-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     126-256: Missing.

Note: No experimental confirmation available.
Show »
Length:204
Mass (Da):22,785
Checksum:iE7DEE14130014CD5
GO
Isoform 7 (identifier: Q9NQ25-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     19-125: Missing.
     217-256: Missing.

Note: No experimental confirmation available.
Show »
Length:188
Mass (Da):21,316
Checksum:i76BA8CF2C70B4663
GO

Sequence cautioni

The sequence CAB76561 differs from that shown. Reason: Frameshift at several positions. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti135 – 1351M → L in CAB81950 (PubMed:11802771).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti175 – 1751H → Y.
Corresponds to variant rs35325048 [ dbSNP | Ensembl ].
VAR_049938
Natural varianti302 – 3021T → M.
Corresponds to variant rs2295617 [ dbSNP | Ensembl ].
VAR_049939

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei19 – 125107Missing in isoform 2 and isoform 7. 2 PublicationsVSP_013781Add
BLAST
Alternative sequencei126 – 256131Missing in isoform 6. 1 PublicationVSP_055292Add
BLAST
Alternative sequencei127 – 16539HLSKP…IYTWK → NNPKGRSSKYGLLHCGNTEK DGKSPLTAHDARHTKAICL in isoform 4. 1 PublicationVSP_054540Add
BLAST
Alternative sequencei166 – 335170Missing in isoform 4. 1 PublicationVSP_054541Add
BLAST
Alternative sequencei217 – 25640Missing in isoform 7. 1 PublicationVSP_055293Add
BLAST
Alternative sequencei258 – 33578YIEEK…YENVI → NNPKGRSSKYGLLHCGNTEK DGKSPLTAHDARHTKAICL in isoform 5. CuratedVSP_054542Add
BLAST
Alternative sequencei258 – 29639YIEEK…RTILK → NNPKGRSSKYGLLHCGNTEK DGKSPLTAHDARHTKAICL in isoform 3. 2 PublicationsVSP_013782Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF291815 mRNA. Translation: AAK11549.1.
AF390894 mRNA. Translation: AAL26989.1.
AJ271869 mRNA. Translation: CAB76561.1. Frameshift.
AJ276429 mRNA. Translation: CAB81950.2.
AB027233 mRNA. Translation: BAB61022.1.
AY358512 mRNA. Translation: AAQ88876.1.
AK290706 mRNA. Translation: BAF83395.1.
AK298499 mRNA. Translation: BAG60706.1.
AK298548 mRNA. Translation: BAG60745.1.
AK301438 mRNA. Translation: BAG62965.1.
AL834424 mRNA. Translation: CAD39085.1.
AL121985 Genomic DNA. Translation: CAC00579.1.
AL121985 Genomic DNA. Translation: CAH73507.1.
AL121985 Genomic DNA. Translation: CAH73508.1.
CH471121 Genomic DNA. Translation: EAW52704.1.
BC027867 mRNA. Translation: AAH27867.1.
CCDSiCCDS1209.1. [Q9NQ25-1]
CCDS60321.1. [Q9NQ25-5]
CCDS60322.1. [Q9NQ25-6]
CCDS60323.1. [Q9NQ25-4]
CCDS60324.1. [Q9NQ25-2]
CCDS60325.1. [Q9NQ25-7]
RefSeqiNP_001269517.1. NM_001282588.1. [Q9NQ25-4]
NP_001269518.1. NM_001282589.1. [Q9NQ25-6]
NP_001269519.1. NM_001282590.1. [Q9NQ25-2]
NP_001269520.1. NM_001282591.1. [Q9NQ25-7]
NP_001269521.1. NM_001282592.1. [Q9NQ25-5]
NP_001269524.1. NM_001282595.1.
NP_067004.3. NM_021181.4. [Q9NQ25-1]
UniGeneiHs.517265.

Genome annotation databases

EnsembliENST00000359331; ENSP00000352281; ENSG00000026751. [Q9NQ25-5]
ENST00000368042; ENSP00000357021; ENSG00000026751. [Q9NQ25-2]
ENST00000368043; ENSP00000357022; ENSG00000026751. [Q9NQ25-1]
ENST00000441662; ENSP00000405605; ENSG00000026751. [Q9NQ25-6]
ENST00000444090; ENSP00000416592; ENSG00000026751. [Q9NQ25-4]
ENST00000458602; ENSP00000409965; ENSG00000026751. [Q9NQ25-7]
GeneIDi57823.
KEGGihsa:57823.
UCSCiuc001fwq.5. human. [Q9NQ25-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF291815 mRNA. Translation: AAK11549.1.
AF390894 mRNA. Translation: AAL26989.1.
AJ271869 mRNA. Translation: CAB76561.1. Frameshift.
AJ276429 mRNA. Translation: CAB81950.2.
AB027233 mRNA. Translation: BAB61022.1.
AY358512 mRNA. Translation: AAQ88876.1.
AK290706 mRNA. Translation: BAF83395.1.
AK298499 mRNA. Translation: BAG60706.1.
AK298548 mRNA. Translation: BAG60745.1.
AK301438 mRNA. Translation: BAG62965.1.
AL834424 mRNA. Translation: CAD39085.1.
AL121985 Genomic DNA. Translation: CAC00579.1.
AL121985 Genomic DNA. Translation: CAH73507.1.
AL121985 Genomic DNA. Translation: CAH73508.1.
CH471121 Genomic DNA. Translation: EAW52704.1.
BC027867 mRNA. Translation: AAH27867.1.
CCDSiCCDS1209.1. [Q9NQ25-1]
CCDS60321.1. [Q9NQ25-5]
CCDS60322.1. [Q9NQ25-6]
CCDS60323.1. [Q9NQ25-4]
CCDS60324.1. [Q9NQ25-2]
CCDS60325.1. [Q9NQ25-7]
RefSeqiNP_001269517.1. NM_001282588.1. [Q9NQ25-4]
NP_001269518.1. NM_001282589.1. [Q9NQ25-6]
NP_001269519.1. NM_001282590.1. [Q9NQ25-2]
NP_001269520.1. NM_001282591.1. [Q9NQ25-7]
NP_001269521.1. NM_001282592.1. [Q9NQ25-5]
NP_001269524.1. NM_001282595.1.
NP_067004.3. NM_021181.4. [Q9NQ25-1]
UniGeneiHs.517265.

3D structure databases

ProteinModelPortaliQ9NQ25.
SMRiQ9NQ25. Positions 31-216.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121782. 16 interactions.
IntActiQ9NQ25. 5 interactions.
MINTiMINT-4722730.
STRINGi9606.ENSP00000357022.

Chemistry

ChEMBLiCHEMBL3559386.
DrugBankiDB06317. Elotuzumab.
GuidetoPHARMACOLOGYi2850.

PTM databases

iPTMnetiQ9NQ25.
PhosphoSiteiQ9NQ25.

Polymorphism and mutation databases

DMDMi66774034.

Proteomic databases

MaxQBiQ9NQ25.
PaxDbiQ9NQ25.
PeptideAtlasiQ9NQ25.
PRIDEiQ9NQ25.
TopDownProteomicsiQ9NQ25-2. [Q9NQ25-2]

Protocols and materials databases

DNASUi57823.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000359331; ENSP00000352281; ENSG00000026751. [Q9NQ25-5]
ENST00000368042; ENSP00000357021; ENSG00000026751. [Q9NQ25-2]
ENST00000368043; ENSP00000357022; ENSG00000026751. [Q9NQ25-1]
ENST00000441662; ENSP00000405605; ENSG00000026751. [Q9NQ25-6]
ENST00000444090; ENSP00000416592; ENSG00000026751. [Q9NQ25-4]
ENST00000458602; ENSP00000409965; ENSG00000026751. [Q9NQ25-7]
GeneIDi57823.
KEGGihsa:57823.
UCSCiuc001fwq.5. human. [Q9NQ25-1]

Organism-specific databases

CTDi57823.
GeneCardsiSLAMF7.
HGNCiHGNC:21394. SLAMF7.
HPAiCAB015445.
HPA055945.
MIMi606625. gene.
neXtProtiNX_Q9NQ25.
PharmGKBiPA134977110.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IJW6. Eukaryota.
ENOG41117FX. LUCA.
GeneTreeiENSGT00530000063114.
HOGENOMiHOG000013065.
HOVERGENiHBG079189.
InParanoidiQ9NQ25.
KOiK06733.
OMAiCPHSGEN.
OrthoDBiEOG091G0KKU.
PhylomeDBiQ9NQ25.
TreeFamiTF334964.

Enzyme and pathway databases

ReactomeiR-HSA-198933. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.

Miscellaneous databases

GeneWikiiSLAMF7.
GenomeRNAii57823.
PROiQ9NQ25.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000026751.
CleanExiHS_SLAMF7.
ExpressionAtlasiQ9NQ25. baseline and differential.
GenevisibleiQ9NQ25. HS.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF07686. V-set. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 2 hits.
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSLAF7_HUMAN
AccessioniPrimary (citable) accession number: Q9NQ25
Secondary accession number(s): A8K3U1
, B4DPU4, B4DPY3, B4DWA3, Q8N6Y8, Q8ND32, Q9NY08, Q9NY23
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 24, 2005
Last sequence update: October 1, 2000
Last modified: September 7, 2016
This is version 136 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Proposed to be involved in systemic lupus erythematosus (SLE) disease process.1 Publication

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.