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Protein

SLAM family member 7

Gene

SLAMF7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Isoform 1 mediates NK cell activation through a SH2D1A-independent extracellular signal-regulated ERK-mediated pathway. May play a role in lymphocyte adhesion.
Isoform 3 does not mediate any NK cell activation.

GO - Molecular functioni

GO - Biological processi

  • cell adhesion Source: UniProtKB
  • natural killer cell activation Source: UniProtKB
  • natural killer cell mediated cytotoxicity Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Names & Taxonomyi

Protein namesi
Recommended name:
SLAM family member 7
Alternative name(s):
CD2 subset 1
CD2-like receptor-activating cytotoxic cells
Short name:
CRACC
Membrane protein FOAP-12
Novel Ly9
Protein 19A
CD_antigen: CD319
Gene namesi
Name:SLAMF7
Synonyms:CS1
ORF Names:UNQ576/PRO1138
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:21394. SLAMF7.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini23 – 226204ExtracellularSequence AnalysisAdd
BLAST
Transmembranei227 – 24721HelicalSequence AnalysisAdd
BLAST
Topological domaini248 – 33588CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134977110.

Polymorphism and mutation databases

DMDMi66774034.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 22221 PublicationAdd
BLAST
Chaini23 – 335313SLAM family member 7PRO_0000014963Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi98 – 981N-linked (GlcNAc...)Sequence Analysis
Glycosylationi142 – 1421N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi145 ↔ 215PROSITE-ProRule annotation
Glycosylationi148 – 1481N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi151 ↔ 195PROSITE-ProRule annotation
Glycosylationi172 – 1721N-linked (GlcNAc...)Sequence Analysis
Glycosylationi176 – 1761N-linked (GlcNAc...)Sequence Analysis
Glycosylationi204 – 2041N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ9NQ25.
PaxDbiQ9NQ25.
PRIDEiQ9NQ25.

PTM databases

PhosphoSiteiQ9NQ25.

Expressioni

Tissue specificityi

Expressed in spleen, lymph node, peripheral blood leukocytes, bone marrow, small intestine, stomach, appendix, lung and trachea. Expression was detected in NK cells, activated B-cells, NK-cell line but not in promyelocytic, B-, or T-cell lines. Isoform 3 is expressed at much lower level than isoform 1.4 Publications

Gene expression databases

BgeeiQ9NQ25.
CleanExiHS_SLAMF7.
ExpressionAtlasiQ9NQ25. baseline and differential.
GenevisibleiQ9NQ25. HS.

Organism-specific databases

HPAiCAB015445.
HPA055945.

Interactioni

Subunit structurei

Isoform 1 binds to SH2D1A when its cytoplasmic tail is phosphorylated in the presence of FYN (in vitro).1 Publication

Protein-protein interaction databases

BioGridi121782. 12 interactions.
IntActiQ9NQ25. 3 interactions.
MINTiMINT-4722730.
STRINGi9606.ENSP00000357022.

Structurei

3D structure databases

ProteinModelPortaliQ9NQ25.
SMRiQ9NQ25. Positions 31-216.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini23 – 124102Ig-like V-typeAdd
BLAST
Domaini131 – 20676Ig-like C2-typeAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG272174.
GeneTreeiENSGT00530000063114.
HOGENOMiHOG000013065.
HOVERGENiHBG079189.
InParanoidiQ9NQ25.
KOiK06733.
OMAiCPHSGEN.
OrthoDBiEOG77HDFC.
PhylomeDBiQ9NQ25.
TreeFamiTF334964.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
IPR015631. SLAM_fam_rcpts.
[Graphical view]
PANTHERiPTHR12080. PTHR12080. 1 hit.
PfamiPF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
[Graphical view]
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]

Sequences (7)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 7 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9NQ25-1) [UniParc]FASTAAdd to basket

Also known as: 19A, CS1-L

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAGSPTCLTL IYILWQLTGS AASGPVKELV GSVGGAVTFP LKSKVKQVDS
60 70 80 90 100
IVWTFNTTPL VTIQPEGGTI IVTQNRNRER VDFPDGGYSL KLSKLKKNDS
110 120 130 140 150
GIYYVGIYSS SLQQPSTQEY VLHVYEHLSK PKVTMGLQSN KNGTCVTNLT
160 170 180 190 200
CCMEHGEEDV IYTWKALGQA ANESHNGSIL PISWRWGESD MTFICVARNP
210 220 230 240 250
VSRNFSSPIL ARKLCEGAAD DPDSSMVLLC LLLVPLLLSL FVLGLFLWFL
260 270 280 290 300
KRERQEEYIE EKKRVDICRE TPNICPHSGE NTEYDTIPHT NRTILKEDPA
310 320 330
NTVYSTVEIP KKMENPHSLL TMPDTPRLFA YENVI
Length:335
Mass (Da):37,421
Last modified:October 1, 2000 - v1
Checksum:iD09ABBCFF74BE8D4
GO
Isoform 2 (identifier: Q9NQ25-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     19-125: Missing.

Note: No experimental confirmation available.
Show »
Length:228
Mass (Da):25,831
Checksum:i2B01DB70E7BBFC14
GO
Isoform 3 (identifier: Q9NQ25-3) [UniParc]FASTAAdd to basket

Also known as: 19A24, CS1-S

The sequence of this isoform differs from the canonical sequence as follows:
     258-296: YIEEKKRVDI...IPHTNRTILK → NNPKGRSSKY...DARHTKAICL

Show »
Length:335
Mass (Da):37,026
Checksum:i3CD49C30FF3367B0
GO
Isoform 4 (identifier: Q9NQ25-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     127-165: HLSKPKVTMG...GEEDVIYTWK → NNPKGRSSKY...DARHTKAICL
     166-335: Missing.

Note: No experimental confirmation available.
Show »
Length:165
Mass (Da):17,945
Checksum:iE70079B2E27C5978
GO
Isoform 5 (identifier: Q9NQ25-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     258-335: YIEEKKRVDI...PRLFAYENVI → NNPKGRSSKY...DARHTKAICL

Note: No experimental confirmation available.
Show »
Length:296
Mass (Da):32,581
Checksum:iE85D277192494EEC
GO
Isoform 6 (identifier: Q9NQ25-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     126-256: Missing.

Note: No experimental confirmation available.
Show »
Length:204
Mass (Da):22,785
Checksum:iE7DEE14130014CD5
GO
Isoform 7 (identifier: Q9NQ25-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     19-125: Missing.
     217-256: Missing.

Note: No experimental confirmation available.
Show »
Length:188
Mass (Da):21,316
Checksum:i76BA8CF2C70B4663
GO

Sequence cautioni

The sequence CAB76561.1 differs from that shown. Reason: Frameshift at several positions. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti135 – 1351M → L in CAB81950 (PubMed:11802771).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti175 – 1751H → Y.
Corresponds to variant rs35325048 [ dbSNP | Ensembl ].
VAR_049938
Natural varianti302 – 3021T → M.
Corresponds to variant rs2295617 [ dbSNP | Ensembl ].
VAR_049939

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei19 – 125107Missing in isoform 2 and isoform 7. 2 PublicationsVSP_013781Add
BLAST
Alternative sequencei126 – 256131Missing in isoform 6. 1 PublicationVSP_055292Add
BLAST
Alternative sequencei127 – 16539HLSKP…IYTWK → NNPKGRSSKYGLLHCGNTEK DGKSPLTAHDARHTKAICL in isoform 4. 1 PublicationVSP_054540Add
BLAST
Alternative sequencei166 – 335170Missing in isoform 4. 1 PublicationVSP_054541Add
BLAST
Alternative sequencei217 – 25640Missing in isoform 7. 1 PublicationVSP_055293Add
BLAST
Alternative sequencei258 – 33578YIEEK…YENVI → NNPKGRSSKYGLLHCGNTEK DGKSPLTAHDARHTKAICL in isoform 5. CuratedVSP_054542Add
BLAST
Alternative sequencei258 – 29639YIEEK…RTILK → NNPKGRSSKYGLLHCGNTEK DGKSPLTAHDARHTKAICL in isoform 3. 2 PublicationsVSP_013782Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF291815 mRNA. Translation: AAK11549.1.
AF390894 mRNA. Translation: AAL26989.1.
AJ271869 mRNA. Translation: CAB76561.1. Frameshift.
AJ276429 mRNA. Translation: CAB81950.2.
AB027233 mRNA. Translation: BAB61022.1.
AY358512 mRNA. Translation: AAQ88876.1.
AK290706 mRNA. Translation: BAF83395.1.
AK298499 mRNA. Translation: BAG60706.1.
AK298548 mRNA. Translation: BAG60745.1.
AK301438 mRNA. Translation: BAG62965.1.
AL834424 mRNA. Translation: CAD39085.1.
AL121985 Genomic DNA. Translation: CAC00579.1.
AL121985 Genomic DNA. Translation: CAH73507.1.
AL121985 Genomic DNA. Translation: CAH73508.1.
CH471121 Genomic DNA. Translation: EAW52704.1.
BC027867 mRNA. Translation: AAH27867.1.
CCDSiCCDS1209.1. [Q9NQ25-1]
CCDS60321.1. [Q9NQ25-5]
CCDS60322.1. [Q9NQ25-6]
CCDS60323.1. [Q9NQ25-4]
CCDS60324.1. [Q9NQ25-2]
CCDS60325.1. [Q9NQ25-7]
RefSeqiNP_001269517.1. NM_001282588.1. [Q9NQ25-4]
NP_001269518.1. NM_001282589.1. [Q9NQ25-6]
NP_001269519.1. NM_001282590.1. [Q9NQ25-2]
NP_001269520.1. NM_001282591.1. [Q9NQ25-7]
NP_001269521.1. NM_001282592.1. [Q9NQ25-5]
NP_001269524.1. NM_001282595.1.
NP_067004.3. NM_021181.4. [Q9NQ25-1]
UniGeneiHs.517265.

Genome annotation databases

EnsembliENST00000359331; ENSP00000352281; ENSG00000026751. [Q9NQ25-5]
ENST00000368042; ENSP00000357021; ENSG00000026751. [Q9NQ25-2]
ENST00000368043; ENSP00000357022; ENSG00000026751.
ENST00000441662; ENSP00000405605; ENSG00000026751. [Q9NQ25-6]
ENST00000444090; ENSP00000416592; ENSG00000026751. [Q9NQ25-4]
ENST00000458602; ENSP00000409965; ENSG00000026751. [Q9NQ25-7]
GeneIDi57823.
KEGGihsa:57823.
UCSCiuc001fwq.3. human. [Q9NQ25-1]
uc001fwr.3. human.
uc001fws.3. human. [Q9NQ25-2]
uc010pjo.2. human.
uc010pjp.2. human.
uc010pjq.2. human.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF291815 mRNA. Translation: AAK11549.1.
AF390894 mRNA. Translation: AAL26989.1.
AJ271869 mRNA. Translation: CAB76561.1. Frameshift.
AJ276429 mRNA. Translation: CAB81950.2.
AB027233 mRNA. Translation: BAB61022.1.
AY358512 mRNA. Translation: AAQ88876.1.
AK290706 mRNA. Translation: BAF83395.1.
AK298499 mRNA. Translation: BAG60706.1.
AK298548 mRNA. Translation: BAG60745.1.
AK301438 mRNA. Translation: BAG62965.1.
AL834424 mRNA. Translation: CAD39085.1.
AL121985 Genomic DNA. Translation: CAC00579.1.
AL121985 Genomic DNA. Translation: CAH73507.1.
AL121985 Genomic DNA. Translation: CAH73508.1.
CH471121 Genomic DNA. Translation: EAW52704.1.
BC027867 mRNA. Translation: AAH27867.1.
CCDSiCCDS1209.1. [Q9NQ25-1]
CCDS60321.1. [Q9NQ25-5]
CCDS60322.1. [Q9NQ25-6]
CCDS60323.1. [Q9NQ25-4]
CCDS60324.1. [Q9NQ25-2]
CCDS60325.1. [Q9NQ25-7]
RefSeqiNP_001269517.1. NM_001282588.1. [Q9NQ25-4]
NP_001269518.1. NM_001282589.1. [Q9NQ25-6]
NP_001269519.1. NM_001282590.1. [Q9NQ25-2]
NP_001269520.1. NM_001282591.1. [Q9NQ25-7]
NP_001269521.1. NM_001282592.1. [Q9NQ25-5]
NP_001269524.1. NM_001282595.1.
NP_067004.3. NM_021181.4. [Q9NQ25-1]
UniGeneiHs.517265.

3D structure databases

ProteinModelPortaliQ9NQ25.
SMRiQ9NQ25. Positions 31-216.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121782. 12 interactions.
IntActiQ9NQ25. 3 interactions.
MINTiMINT-4722730.
STRINGi9606.ENSP00000357022.

PTM databases

PhosphoSiteiQ9NQ25.

Polymorphism and mutation databases

DMDMi66774034.

Proteomic databases

MaxQBiQ9NQ25.
PaxDbiQ9NQ25.
PRIDEiQ9NQ25.

Protocols and materials databases

DNASUi57823.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000359331; ENSP00000352281; ENSG00000026751. [Q9NQ25-5]
ENST00000368042; ENSP00000357021; ENSG00000026751. [Q9NQ25-2]
ENST00000368043; ENSP00000357022; ENSG00000026751.
ENST00000441662; ENSP00000405605; ENSG00000026751. [Q9NQ25-6]
ENST00000444090; ENSP00000416592; ENSG00000026751. [Q9NQ25-4]
ENST00000458602; ENSP00000409965; ENSG00000026751. [Q9NQ25-7]
GeneIDi57823.
KEGGihsa:57823.
UCSCiuc001fwq.3. human. [Q9NQ25-1]
uc001fwr.3. human.
uc001fws.3. human. [Q9NQ25-2]
uc010pjo.2. human.
uc010pjp.2. human.
uc010pjq.2. human.

Organism-specific databases

CTDi57823.
GeneCardsiGC01P160709.
HGNCiHGNC:21394. SLAMF7.
HPAiCAB015445.
HPA055945.
MIMi606625. gene.
neXtProtiNX_Q9NQ25.
PharmGKBiPA134977110.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG272174.
GeneTreeiENSGT00530000063114.
HOGENOMiHOG000013065.
HOVERGENiHBG079189.
InParanoidiQ9NQ25.
KOiK06733.
OMAiCPHSGEN.
OrthoDBiEOG77HDFC.
PhylomeDBiQ9NQ25.
TreeFamiTF334964.

Miscellaneous databases

GeneWikiiSLAMF7.
GenomeRNAii57823.
NextBioi35464059.
PROiQ9NQ25.
SOURCEiSearch...

Gene expression databases

BgeeiQ9NQ25.
CleanExiHS_SLAMF7.
ExpressionAtlasiQ9NQ25. baseline and differential.
GenevisibleiQ9NQ25. HS.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
IPR015631. SLAM_fam_rcpts.
[Graphical view]
PANTHERiPTHR12080. PTHR12080. 1 hit.
PfamiPF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
[Graphical view]
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning of CS1, a novel human natural killer cell receptor belonging to the CD2 subset of the immunoglobulin superfamily."
    Boles K.S., Mathew P.A.
    Immunogenetics 52:302-307(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
  2. "Activation of NK cell-mediated cytotoxicity by a SAP-independent receptor of the CD2 family."
    Bouchon A., Cella M., Grierson H.L., Cohen J.I., Colonna M.
    J. Immunol. 167:5517-5521(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, TISSUE SPECIFICITY.
  3. "A novel immunoglobulin superfamily receptor (19A) related to CD2 is expressed on activated lymphocytes and promotes homotypic B-cell adhesion."
    Murphy J.J., Hobby P., Vilarino-Varela J., Bishop B., Iordanidou P., Sutton B.J., Norton J.D.
    Biochem. J. 361:431-436(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 3), FUNCTION, TISSUE SPECIFICITY.
  4. "Homo sapiens mRNA for FOAP-12 protein, complete cds."
    Fujii Y., Takayama K., Tsuritani K., Yajima Y., Amemiya T., Ukai Y., Naito K., Kawaguchi A.
    Submitted (MAY-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Macrophage.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  6. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 4; 6 AND 7).
    Tissue: Lung and Synovium.
  7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Lymph node.
  8. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  9. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  10. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    Tissue: Fetal lung and Fetal spleen.
  11. "Signal peptide prediction based on analysis of experimentally verified cleavage sites."
    Zhang Z., Henzel W.J.
    Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 23-37.
  12. "Molecular and functional characterization of a CS1 (CRACC) splice variant expressed in human NK cells that does not contain immunoreceptor tyrosine-based switch motifs."
    Lee J.K., Boles K.S., Mathew P.A.
    Eur. J. Immunol. 34:2791-2799(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: ALTERNATIVE SPLICING (ISOFORM 3).
  13. "Mouse novel Ly9: a new member of the expanding CD150 (SLAM) family of leukocyte cell-surface receptors."
    Tovar V., Del Valle J., Zapater N., Martin M., Romero X., Pizcueta P., Bosch J., Terhorst C., Engel P.
    Immunogenetics 54:394-402(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY, INTERACTION WITH SH2D1A.

Entry informationi

Entry nameiSLAF7_HUMAN
AccessioniPrimary (citable) accession number: Q9NQ25
Secondary accession number(s): A8K3U1
, B4DPU4, B4DPY3, B4DWA3, Q8N6Y8, Q8ND32, Q9NY08, Q9NY23
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 24, 2005
Last sequence update: October 1, 2000
Last modified: July 22, 2015
This is version 125 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.