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Protein

Transcriptional repressor scratch 2

Gene

SCRT2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri155 – 17723C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri186 – 20823C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri212 – 23423C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri240 – 26223C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri268 – 29124C2H2-type 5; atypicalPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Transcriptional repressor scratch 2
Alternative name(s):
Scratch homolog 2 zinc finger protein
Gene namesi
Name:SCRT2
ORF Names:FP7030
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

HGNCiHGNC:15952. SCRT2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA35016.

Polymorphism and mutation databases

BioMutaiSCRT2.
DMDMi46397045.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 307307Transcriptional repressor scratch 2PRO_0000047038Add
BLAST

Proteomic databases

PaxDbiQ9NQ03.
PRIDEiQ9NQ03.

PTM databases

iPTMnetiQ9NQ03.
PhosphoSiteiQ9NQ03.

Expressioni

Gene expression databases

BgeeiQ9NQ03.
CleanExiHS_SCRT2.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000246104.

Structurei

3D structure databases

ProteinModelPortaliQ9NQ03.
SMRiQ9NQ03. Positions 151-292.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 2020SNAG domainBy similarityAdd
BLAST

Sequence similaritiesi

Contains 5 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri155 – 17723C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri186 – 20823C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri212 – 23423C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri240 – 26223C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri268 – 29124C2H2-type 5; atypicalPROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG2462. Eukaryota.
ENOG41106JS. LUCA.
GeneTreeiENSGT00390000011027.
HOGENOMiHOG000261665.
HOVERGENiHBG007477.
InParanoidiQ9NQ03.
KOiK09219.
OMAiPGDNGYV.
OrthoDBiEOG7P2XSG.
PhylomeDBiQ9NQ03.
TreeFamiTF315515.

Family and domain databases

Gene3Di3.30.160.60. 3 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 2 hits.
PF13912. zf-C2H2_6. 2 hits.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 5 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 4 hits.
PS50157. ZINC_FINGER_C2H2_2. 5 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9NQ03-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPRSFLVKKI KGDGFQCSGV PAPTYHPLET AYVLPGARGP PGDNGYAPHR
60 70 80 90 100
LPPSSYDADQ KPGLELAPAE PAYPPAAPEE YSDPESPQSS LSARYFRGEA
110 120 130 140 150
AVTDSYSMDA FFISDGRSRR RRGGGGGDAG GSGDAGGAGG RAGRAGAQAG
160 170 180 190 200
GGHRHACAEC GKTYATSSNL SRHKQTHRSL DSQLARKCPT CGKAYVSMPA
210 220 230 240 250
LAMHLLTHNL RHKCGVCGKA FSRPWLLQGH MRSHTGEKPF GCAHCGKAFA
260 270 280 290 300
DRSNLRAHMQ THSAFKHYRC RQCDKSFALK SYLHKHCEAA CAKAAEPPPP

TPAGPAS
Length:307
Mass (Da):32,584
Last modified:April 13, 2004 - v3
Checksum:iE9328725903F9C17
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY129025 mRNA. Translation: AAM98768.1.
AL121758 Genomic DNA. Translation: CAC00548.3.
CCDSiCCDS13006.1.
RefSeqiNP_149120.1. NM_033129.3.
UniGeneiHs.355284.

Genome annotation databases

EnsembliENST00000246104; ENSP00000246104; ENSG00000215397.
GeneIDi85508.
KEGGihsa:85508.
UCSCiuc002wec.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY129025 mRNA. Translation: AAM98768.1.
AL121758 Genomic DNA. Translation: CAC00548.3.
CCDSiCCDS13006.1.
RefSeqiNP_149120.1. NM_033129.3.
UniGeneiHs.355284.

3D structure databases

ProteinModelPortaliQ9NQ03.
SMRiQ9NQ03. Positions 151-292.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000246104.

PTM databases

iPTMnetiQ9NQ03.
PhosphoSiteiQ9NQ03.

Polymorphism and mutation databases

BioMutaiSCRT2.
DMDMi46397045.

Proteomic databases

PaxDbiQ9NQ03.
PRIDEiQ9NQ03.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000246104; ENSP00000246104; ENSG00000215397.
GeneIDi85508.
KEGGihsa:85508.
UCSCiuc002wec.3. human.

Organism-specific databases

CTDi85508.
GeneCardsiSCRT2.
HGNCiHGNC:15952. SCRT2.
neXtProtiNX_Q9NQ03.
PharmGKBiPA35016.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2462. Eukaryota.
ENOG41106JS. LUCA.
GeneTreeiENSGT00390000011027.
HOGENOMiHOG000261665.
HOVERGENiHBG007477.
InParanoidiQ9NQ03.
KOiK09219.
OMAiPGDNGYV.
OrthoDBiEOG7P2XSG.
PhylomeDBiQ9NQ03.
TreeFamiTF315515.

Miscellaneous databases

GenomeRNAii85508.
PROiQ9NQ03.

Gene expression databases

BgeeiQ9NQ03.
CleanExiHS_SCRT2.

Family and domain databases

Gene3Di3.30.160.60. 3 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 2 hits.
PF13912. zf-C2H2_6. 2 hits.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 5 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 4 hits.
PS50157. ZINC_FINGER_C2H2_2. 5 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Novel human cDNA clones with function of promoting mice NIH/3T3 cells' growth."
    Wan D.F., Qin W.X., Zhou X.M., Zhang P.P., Jiang H.Q., Gu J.R.
    Submitted (JUL-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  2. "The DNA sequence and comparative analysis of human chromosome 20."
    Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
    , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
    Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiSCRT2_HUMAN
AccessioniPrimary (citable) accession number: Q9NQ03
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: April 13, 2004
Last modified: June 8, 2016
This is version 124 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.