Reviewed,
UniProtKB/Swiss-Prot Q9NPY3 (C1QR1_HUMAN)
Last modified
June 16, 2009.
Version 89.
History...
Clusters with 100%,
90%,
50% identity |
Documents (7) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Complement component C1q receptor Alternative name(s): Complement component 1 q subcomponent receptor 1 C1q/MBL/SPA receptor Short name=C1qR(p) Short name=C1qRp Short name=C1qR Matrix-remodeling-associated protein 4 CDw93 CD_antigen=CD93 | ||||
| Gene names |
| ||||
| Organism | Homo sapiens (Human) | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 652 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Receptor (or element of a larger receptor complex) for C1q, mannose-binding lectin (MBL2) and pulmonary surfactant protein A (SPA). May mediate the enhancement of phagocytosis in monocytes and macrophages upon interaction with soluble defense collagens. May play a role in intercellular adhesion. |
| Subunit structure | Interacts with HCV core protein. Ref.7 |
| Subcellular location | |
| Tissue specificity | Highly expressed in endothelial cells, platelets, cells of myeloid origin, such as monocytes and neutrophils. Not expressed in cells of lymphoid origin. |
| Post-translational modification | N- and O-glycosylated. Ref.6 |
| Sequence similarities | Contains 1 C-type lectin domain. Contains 5 EGF-like domains. |
| Caution | Has been sometimes referred to as a collectin receptor. Ref.5 reported that C1q is not a ligand for C1QR1. |
Ontologies
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||||
Molecule processing | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Signal peptide | 1 – 21 | 21 | |||||||||
| Chain | 22 – 652 | 631 | Complement component C1q receptor | PRO_0000017367 | |||||||
Regions | |||||||||||
| Topological domain | 24 – 580 | 557 | Extracellular Potential | ||||||||
| Transmembrane | 581 – 601 | 21 | Potential | ||||||||
| Topological domain | 602 – 652 | 51 | Cytoplasmic Potential | ||||||||
| Domain | 32 – 174 | 143 | C-type lectin | ||||||||
| Domain | 260 – 301 | 42 | EGF-like 1 | ||||||||
| Domain | 302 – 344 | 43 | EGF-like 2 | ||||||||
| Domain | 345 – 384 | 40 | EGF-like 3; calcium-binding Potential | ||||||||
| Domain | 385 – 426 | 42 | EGF-like 4; calcium-binding Potential | ||||||||
| Domain | 427 – 468 | 42 | EGF-like 5; calcium-binding Potential | ||||||||
Amino acid modifications | |||||||||||
| Modified residue | 644 | 1 | Phosphotyrosine Ref.8 | ||||||||
| Glycosylation | 325 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Disulfide bond | 141 ↔ 165 | By similarity | |||||||||
| Disulfide bond | 264 ↔ 275 | By similarity | |||||||||
| Disulfide bond | 271 ↔ 285 | By similarity | |||||||||
| Disulfide bond | 287 ↔ 300 | By similarity | |||||||||
| Disulfide bond | 306 ↔ 317 | By similarity | |||||||||
| Disulfide bond | 311 ↔ 328 | By similarity | |||||||||
| Disulfide bond | 330 ↔ 343 | By similarity | |||||||||
| Disulfide bond | 349 ↔ 358 | By similarity | |||||||||
| Disulfide bond | 354 ↔ 367 | By similarity | |||||||||
| Disulfide bond | 369 ↔ 383 | By similarity | |||||||||
| Disulfide bond | 389 ↔ 400 | By similarity | |||||||||
| Disulfide bond | 396 ↔ 409 | By similarity | |||||||||
| Disulfide bond | 411 ↔ 425 | By similarity | |||||||||
| Disulfide bond | 431 ↔ 443 | By similarity | |||||||||
| Disulfide bond | 439 ↔ 452 | By similarity | |||||||||
| Disulfide bond | 454 ↔ 467 | By similarity | |||||||||
Natural variations | |||||||||||
| Natural variant | 220 | 1 | A → V in a colorectal cancer sample; somatic mutation. Ref.9 | VAR_036400 | |||||||
| Natural variant | 318 | 1 | V → A Ref.2 | VAR_013573 | |||||||
| Natural variant | 541 | 1 | P → S: dbSNP rs3746731. Ref.1 | VAR_050102 | |||||||
Experimental info | |||||||||||
| Sequence conflict | 22 | 1 | T → V AA sequence Ref.1 | ||||||||
| Sequence conflict | 36 | 1 | C → T AA sequence Ref.1 | ||||||||
| Sequence conflict | 38 – 39 | 2 | TA → RI AA sequence Ref.1 | ||||||||
| Sequence conflict | 155 | 1 | S → N in AAB53110. Ref.1 | ||||||||
| Sequence conflict | 186 | 1 | G → A AA sequence Ref.1 | ||||||||
| Sequence conflict | 492 | 1 | S → A AA sequence Ref.1 | ||||||||
| Sequence conflict | 496 | 1 | R → Q AA sequence Ref.1 | ||||||||
| Sequence conflict | 504 | 1 | R → G AA sequence Ref.1 | ||||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "cDNA cloning and primary structure analysis of C1qR(P), the human C1q/MBL/SPA receptor that mediates enhanced phagocytosis in vitro." Nepomuceno R.R., Henschen-Edman A.H., Burgess W.H., Tenner A.J. Immunity 6:119-129(1997) [PubMed: 9047234] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE, VARIANT SER-541. |
| [2] | "Identification of human CD93 as the phagocytic C1q receptor (C1qRp) by expression cloning." Steinberger P., Szekeres A., Wille S., Stockl J., Selenko N., Prager E., Staffler G., Madic O., Stockinger H., Knapp W. J. Leukoc. Biol. 71:133-140(2002) [PubMed: 11781389] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT ALA-318. |
| [3] | "The DNA sequence and comparative analysis of human chromosome 20." Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E. Rogers J.Nature 414:865-871(2001) [PubMed: 11780052] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| [4] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Leukocyte. |
| [5] | "Human C1qRp is identical with CD93 and the mNI-11 antigen but does not bind C1q." McGreal E.P., Ikewaki N., Akatsu H., Morgan B.P., Gasque P. J. Immunol. 168:5222-5232(2002) [PubMed: 11994479] [Abstract] Cited for: CHARACTERIZATION. |
| [6] | "C1qRP is a heavily O-glycosylated cell surface protein involved in the regulation of phagocytic activity." Nepomuceno R.R., Ruiz S., Park M., Tenner A.J. J. Immunol. 162:3583-3589(1999) [PubMed: 10092817] [Abstract] Cited for: GLYCOSYLATION. |
| [7] | "Interaction between complement receptor gC1qR and hepatitis C virus core protein inhibits T-lymphocyte proliferation." Kittlesen D.J., Chianese-Bullock K.A., Yao Z.Q., Braciale T.J., Hahn Y.S. J. Clin. Invest. 106:1239-1249(2000) [PubMed: 11086025] [Abstract] Cited for: INTERACTION WITH HCV CORE PROTEIN. |
| [8] | "Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer." Rikova K., Guo A., Zeng Q., Possemato A., Yu J., Haack H., Nardone J., Lee K., Reeves C., Li Y., Hu Y., Tan Z., Stokes M., Sullivan L., Mitchell J., Wetzel R., Macneill J., Ren J.M. Comb M.J.Cell 131:1190-1203(2007) [PubMed: 18083107] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-644, MASS SPECTROMETRY. |
| [9] | "The consensus coding sequences of human breast and colorectal cancers." Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. Velculescu V.E.Science 314:268-274(2006) [PubMed: 16959974] [Abstract] Cited for: VARIANT [LARGE SCALE ANALYSIS] VAL-220. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| U94333 mRNA. Translation: AAB53110.1. AL118508 Genomic DNA. Translation: CAC00597.1. BC028075 mRNA. Translation: AAH28075.1. | |
| IPI | IPI00299485. |
| RefSeq | NP_036204.2. |
| UniGene | Hs.97199 |
3D structure databases | |
| HSSP | HSSP built from PDB template 1EMN based on UniProtKB P35555. |
| ModBase | Search... |
Protein-protein interaction databases | |
| IntAct | Q9NPY3. 1 interaction. |
PTM databases | |
| PhosphoSite | Q9NPY3. |
Proteomic databases | |
| PeptideAtlas | Q9NPY3. |
| PRIDE | Q9NPY3. |
Genome annotation databases | |
| Ensembl | ENSG00000125810. Homo sapiens. [Contig view] |
| GeneID | 22918. |
| KEGG | hsa:22918. |
Organism-specific databases | |
| GeneCards | GC20M023008. |
| H-InvDB | HIX0015687. |
| HGNC | HGNC:15855. CD93. |
| HPA | HPA009300. HPA012368. |
| MIM | 120577. gene. |
| GenAtlas | Search... |
Phylogenomic databases | |
| HOVERGEN | Q9NPY3. |
| OMA | Q9NPY3. SRNPCSS. |
Gene expression databases | |
| ArrayExpress | Q9NPY3. |
| Bgee | Q9NPY3. |
| CleanEx | HS_CD93. |
| GermOnline | ENSG00000125810. Homo sapiens. |
Family and domain databases | |
| InterPro | IPR001304. C-type_lectin. IPR016186. C-type_lectin-like. IPR018378. C-type_lectin_CS. IPR016316. CD93/CD141. IPR006209. EGF. IPR006210. EGF-like. IPR013032. EGF-like_reg_CS. IPR000152. EGF-type_Asp/Asn_hydroxyl_CS. IPR000742. EGF_3. IPR001881. EGF_Ca_bd. IPR013091. EGF_Ca_bd_2. IPR018097. EGF_Ca_bd_CS. [Graphical view] |
| Gene3D | G3DSA:3.10.100.10. C-type_lectin-like. 1 hit. |
| Pfam | PF00008. EGF. 1 hit. PF07645. EGF_CA. 3 hits. PF00059. Lectin_C. 1 hit. [Graphical view] |
| PIRSF | PIRSF001775. CD93/CD141. 1 hit. |
| SMART | SM00034. CLECT. 1 hit. SM00181. EGF. 2 hits. SM00179. EGF_CA. 3 hits. [Graphical view] |
| PROSITE | PS00010. ASX_HYDROXYL. 3 hits. PS00615. C_TYPE_LECTIN_1. False negative. PS50041. C_TYPE_LECTIN_2. 1 hit. PS01186. EGF_2. 3 hits. PS50026. EGF_3. 3 hits. PS01187. EGF_CA. 3 hits. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 43613. |
| SOURCE | Search... |
Entry information
| Entry name | C1QR1_HUMAN | ||||||||
| Accession | Primary (citable) accession number: Q9NPY3 Secondary accession number(s): O00274 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| Human cell differentiation molecules CD nomenclature of surface proteins of human leucocytes and list of entries |
| Human chromosome 20 Human chromosome 20: entries, gene names and cross-references to MIM |
| Human entries with polymorphisms or disease mutations List of human entries with polymorphisms or disease mutations |
| Human polymorphisms and disease mutations Index of human polymorphisms and disease mutations |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |
| Forthcoming format changes Announcement of forthcoming format changes |

Clusters with


