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Protein

Complement component C1q receptor

Gene

CD93

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Receptor (or element of a larger receptor complex) for C1q, mannose-binding lectin (MBL2) and pulmonary surfactant protein A (SPA). May mediate the enhancement of phagocytosis in monocytes and macrophages upon interaction with soluble defense collagens. May play a role in intercellular adhesion.

GO - Molecular functioni

  • calcium ion binding Source: InterPro
  • carbohydrate binding Source: UniProtKB-KW
  • complement component C1q binding Source: UniProtKB
  • receptor activity Source: UniProtKB

GO - Biological processi

  • macrophage activation Source: UniProtKB
  • neutrophil degranulation Source: Reactome
  • phagocytosis Source: UniProtKB
  • single organismal cell-cell adhesion Source: UniProtKB
  • viral process Source: UniProtKB-KW

Keywordsi

Molecular functionReceptor
Biological processCell adhesion, Host-virus interaction
LigandLectin

Enzyme and pathway databases

ReactomeiR-HSA-6798695. Neutrophil degranulation.

Names & Taxonomyi

Protein namesi
Recommended name:
Complement component C1q receptor
Alternative name(s):
C1q/MBL/SPA receptor
Short name:
C1qR
Short name:
C1qR(p)
Short name:
C1qRp
CDw93
Complement component 1 q subcomponent receptor 1
Matrix-remodeling-associated protein 4
CD_antigen: CD93
Gene namesi
Name:CD93
Synonyms:C1QR1, MXRA4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

EuPathDBiHostDB:ENSG00000125810.9.
HGNCiHGNC:15855. CD93.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini24 – 580ExtracellularSequence analysisAdd BLAST557
Transmembranei581 – 601HelicalSequence analysisAdd BLAST21
Topological domaini602 – 652CytoplasmicSequence analysisAdd BLAST51

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi22918.
OpenTargetsiENSG00000125810.
PharmGKBiPA25627.

Polymorphism and mutation databases

BioMutaiCD93.
DMDMi21759074.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Add BLAST21
ChainiPRO_000001736722 – 652Complement component C1q receptorAdd BLAST631

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi141 ↔ 165By similarity
Disulfide bondi264 ↔ 275By similarity
Disulfide bondi271 ↔ 285By similarity
Disulfide bondi287 ↔ 300By similarity
Disulfide bondi306 ↔ 317By similarity
Disulfide bondi311 ↔ 328By similarity
Glycosylationi325N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi330 ↔ 343By similarity
Disulfide bondi349 ↔ 358By similarity
Disulfide bondi354 ↔ 367By similarity
Disulfide bondi369 ↔ 383By similarity
Disulfide bondi389 ↔ 400By similarity
Disulfide bondi396 ↔ 409By similarity
Disulfide bondi411 ↔ 425By similarity
Disulfide bondi431 ↔ 443By similarity
Disulfide bondi439 ↔ 452By similarity
Disulfide bondi454 ↔ 467By similarity
Modified residuei627PhosphoserineBy similarity1
Modified residuei644PhosphotyrosineBy similarity1

Post-translational modificationi

N- and O-glycosylated.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ9NPY3.
PeptideAtlasiQ9NPY3.
PRIDEiQ9NPY3.
TopDownProteomicsiQ9NPY3.

PTM databases

iPTMnetiQ9NPY3.
PhosphoSitePlusiQ9NPY3.

Expressioni

Tissue specificityi

Highly expressed in endothelial cells, platelets, cells of myeloid origin, such as monocytes and neutrophils. Not expressed in cells of lymphoid origin.

Gene expression databases

BgeeiENSG00000125810.
CleanExiHS_CD93.
GenevisibleiQ9NPY3. HS.

Organism-specific databases

HPAiHPA009300.
HPA012368.

Interactioni

Subunit structurei

Interacts with HCV core protein. Interacts with C1QBP; the association may represent a cell surface C1q receptor.2 Publications

GO - Molecular functioni

  • complement component C1q binding Source: UniProtKB

Protein-protein interaction databases

BioGridi116580. 21 interactors.
IntActiQ9NPY3. 8 interactors.
MINTiMINT-4539936.
STRINGi9606.ENSP00000246006.

Structurei

3D structure databases

ProteinModelPortaliQ9NPY3.
SMRiQ9NPY3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini32 – 174C-type lectinPROSITE-ProRule annotationAdd BLAST143
Domaini260 – 301EGF-like 1PROSITE-ProRule annotationAdd BLAST42
Domaini302 – 344EGF-like 2PROSITE-ProRule annotationAdd BLAST43
Domaini345 – 384EGF-like 3; calcium-bindingPROSITE-ProRule annotationAdd BLAST40
Domaini385 – 426EGF-like 4; calcium-bindingPROSITE-ProRule annotationAdd BLAST42
Domaini427 – 468EGF-like 5; calcium-bindingPROSITE-ProRule annotationAdd BLAST42

Keywords - Domaini

EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IJQN. Eukaryota.
ENOG410ZKXP. LUCA.
GeneTreeiENSGT00810000125382.
HOVERGENiHBG050751.
InParanoidiQ9NPY3.
KOiK06702.
OMAiHYFLCKE.
OrthoDBiEOG091G04OD.
PhylomeDBiQ9NPY3.
TreeFamiTF330714.

Family and domain databases

Gene3Di3.10.100.10. 1 hit.
InterProiView protein in InterPro
IPR001304. C-type_lectin-like.
IPR016186. C-type_lectin-like/link.
IPR026823. cEGF.
IPR016187. CTDL_fold.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR009030. Growth_fac_rcpt_.
PfamiView protein in Pfam
PF12662. cEGF. 1 hit.
PF07645. EGF_CA. 2 hits.
PF00059. Lectin_C. 1 hit.
SMARTiView protein in SMART
SM00034. CLECT. 1 hit.
SM00181. EGF. 5 hits.
SM00179. EGF_CA. 5 hits.
SUPFAMiSSF56436. SSF56436. 1 hit.
SSF57184. SSF57184. 1 hit.
PROSITEiView protein in PROSITE
PS00010. ASX_HYDROXYL. 3 hits.
PS50041. C_TYPE_LECTIN_2. 1 hit.
PS01186. EGF_2. 3 hits.
PS50026. EGF_3. 3 hits.
PS01187. EGF_CA. 3 hits.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9NPY3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATSMGLLLL LLLLLTQPGA GTGADTEAVV CVGTACYTAH SGKLSAAEAQ
60 70 80 90 100
NHCNQNGGNL ATVKSKEEAQ HVQRVLAQLL RREAALTARM SKFWIGLQRE
110 120 130 140 150
KGKCLDPSLP LKGFSWVGGG EDTPYSNWHK ELRNSCISKR CVSLLLDLSQ
160 170 180 190 200
PLLPSRLPKW SEGPCGSPGS PGSNIEGFVC KFSFKGMCRP LALGGPGQVT
210 220 230 240 250
YTTPFQTTSS SLEAVPFASA ANVACGEGDK DETQSHYFLC KEKAPDVFDW
260 270 280 290 300
GSSGPLCVSP KYGCNFNNGG CHQDCFEGGD GSFLCGCRPG FRLLDDLVTC
310 320 330 340 350
ASRNPCSSSP CRGGATCVLG PHGKNYTCRC PQGYQLDSSQ LDCVDVDECQ
360 370 380 390 400
DSPCAQECVN TPGGFRCECW VGYEPGGPGE GACQDVDECA LGRSPCAQGC
410 420 430 440 450
TNTDGSFHCS CEEGYVLAGE DGTQCQDVDE CVGPGGPLCD SLCFNTQGSF
460 470 480 490 500
HCGCLPGWVL APNGVSCTMG PVSLGPPSGP PDEEDKGEKE GSTVPRAATA
510 520 530 540 550
SPTRGPEGTP KATPTTSRPS LSSDAPITSA PLKMLAPSGS PGVWREPSIH
560 570 580 590 600
HATAASGPQE PAGGDSSVAT QNNDGTDGQK LLLFYILGTV VAILLLLALA
610 620 630 640 650
LGLLVYRKRR AKREEKKEKK PQNAADSYSW VPERAESRAM ENQYSPTPGT

DC
Length:652
Mass (Da):68,560
Last modified:July 11, 2002 - v3
Checksum:iEECA0FEAC55FCAC2
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti22T → V AA sequence (PubMed:9047234).Curated1
Sequence conflicti36C → T AA sequence (PubMed:9047234).Curated1
Sequence conflicti38 – 39TA → RI AA sequence (PubMed:9047234).Curated2
Sequence conflicti155S → N in AAB53110 (PubMed:9047234).Curated1
Sequence conflicti186G → A AA sequence (PubMed:9047234).Curated1
Sequence conflicti492S → A AA sequence (PubMed:9047234).Curated1
Sequence conflicti496R → Q AA sequence (PubMed:9047234).Curated1
Sequence conflicti504R → G AA sequence (PubMed:9047234).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_036400220A → V in a colorectal cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs138932459Ensembl.1
Natural variantiVAR_013573318V → A1 Publication1
Natural variantiVAR_050102541P → S1 PublicationCorresponds to variant dbSNP:rs3746731Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U94333 mRNA. Translation: AAB53110.1.
AL118508 Genomic DNA. No translation available.
BC028075 mRNA. Translation: AAH28075.1.
CCDSiCCDS13149.1.
RefSeqiNP_036204.2. NM_012072.3.
UniGeneiHs.97199.

Genome annotation databases

EnsembliENST00000246006; ENSP00000246006; ENSG00000125810.
GeneIDi22918.
KEGGihsa:22918.
UCSCiuc002wsv.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiC1QR1_HUMAN
AccessioniPrimary (citable) accession number: Q9NPY3
Secondary accession number(s): O00274
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 20, 2002
Last sequence update: July 11, 2002
Last modified: September 27, 2017
This is version 168 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Has been sometimes referred to as a collectin receptor.Curated
PubMed:11994479 reported that C1q is not a ligand for C1QR1.Curated

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot