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Q9NPR9

- GP108_HUMAN

UniProt

Q9NPR9 - GP108_HUMAN

Protein

Protein GPR108

Gene

GPR108

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 77 (01 Oct 2014)
      Sequence version 3 (18 May 2010)
      Previous versions | rss
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    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein GPR108
    Alternative name(s):
    Lung seven transmembrane receptor 2
    Gene namesi
    Name:GPR108
    Synonyms:LUSTR2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:17829. GPR108.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA28855.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 3232Sequence AnalysisAdd
    BLAST
    Chaini33 – 543511Protein GPR108PRO_0000045083Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi57 – 571N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi109 – 1091N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi200 – 2001N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi204 – 2041N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi228 – 2281N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi534 – 5341N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    MaxQBiQ9NPR9.
    PaxDbiQ9NPR9.
    PRIDEiQ9NPR9.

    PTM databases

    PhosphoSiteiQ9NPR9.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9NPR9.
    BgeeiQ9NPR9.
    CleanExiHS_GPR108.
    GenevestigatoriQ9NPR9.

    Organism-specific databases

    HPAiHPA041924.
    HPA041951.

    Interactioni

    Protein-protein interaction databases

    BioGridi121254. 2 interactions.
    STRINGi9606.ENSP00000264080.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9NPR9.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei263 – 28321Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei292 – 31221Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei336 – 35621Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei367 – 38721Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei401 – 42121Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei449 – 46921Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei473 – 49321Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the LU7TM family.Curated

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG294185.
    HOGENOMiHOG000238447.
    HOVERGENiHBG056147.
    InParanoidiQ9NPR9.
    OMAiVMHYITH.
    OrthoDBiEOG7D85WF.
    PhylomeDBiQ9NPR9.
    TreeFamiTF314804.

    Family and domain databases

    InterProiIPR009637. TM_rcpt_euk.
    [Graphical view]
    PANTHERiPTHR21229. PTHR21229. 1 hit.
    PfamiPF06814. Lung_7-TM_R. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9NPR9-1 [UniParc]FASTAAdd to Basket

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    MAVSERRGLG RGSPAEWGQR LLLVLLLGGC SGRIHQLALT GEKRADIQLN    50
    SFGFYTNGSL EVELSVLRLG LREAEEKSLL VGFSLSRVRS GRVRSYSTRD 100
    FQDCPLQKNS SSFLVLFLIN TKDLQVQVRK YGEQKTLFIF PGLLPEAPSK 150
    PGLPKPQATV PRKVDGGGTS AASKPKSTPA VIQGPSGKDK DLVLGLSHLN 200
    NSYNFSFHVV IGSQAEEGQY SLNFHNCNNS VPGKEHPFDI TVMIREKNPD 250
    GFLSAAEMPL FKLYMVMSAC FLAAGIFWVS ILCRNTYSVF KIHWLMAALA 300
    FTKSISLLFH SINYYFINSQ GHPIEGLAVM YYIAHLLKGA LLFITIALIG 350
    SGWAFIKYVL SDKEKKVFGI VIPMQVLANV AYIIIESREE GASDYVLWKE 400
    ILFLVDLICC GAILFPVVWS IRHLQDASGT DGKVAVNLAK LKLFRHYYVM 450
    VICYVYFTRI IAILLQVAVP FQWQWLYQLL VEGSTLAFFV LTGYKFQPTG 500
    NNPYLQLPQE DEEDVQMEQV MTDSGFREGL SKVNKTASGR ELL 543
    Length:543
    Mass (Da):60,633
    Last modified:May 18, 2010 - v3
    Checksum:i72B853EA61DEF58A
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti36 – 361Q → R.2 Publications
    Corresponds to variant rs340138 [ dbSNP | Ensembl ].
    VAR_060483
    Natural varianti79 – 791L → P.
    Corresponds to variant rs4807897 [ dbSNP | Ensembl ].
    VAR_056112

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH471139 Genomic DNA. Translation: EAW69067.1.
    AC008760 Genomic DNA. No translation available.
    BC146909 mRNA. Translation: AAI46910.1.
    AL365404 mRNA. Translation: CAB96950.1.
    CCDSiCCDS42479.1.
    RefSeqiNP_001073921.1. NM_001080452.1.
    UniGeneiHs.167641.

    Genome annotation databases

    EnsembliENST00000264080; ENSP00000264080; ENSG00000125734.
    GeneIDi56927.
    KEGGihsa:56927.
    UCSCiuc002mfp.3. human.

    Polymorphism databases

    DMDMi296439338.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH471139 Genomic DNA. Translation: EAW69067.1 .
    AC008760 Genomic DNA. No translation available.
    BC146909 mRNA. Translation: AAI46910.1 .
    AL365404 mRNA. Translation: CAB96950.1 .
    CCDSi CCDS42479.1.
    RefSeqi NP_001073921.1. NM_001080452.1.
    UniGenei Hs.167641.

    3D structure databases

    ProteinModelPortali Q9NPR9.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 121254. 2 interactions.
    STRINGi 9606.ENSP00000264080.

    PTM databases

    PhosphoSitei Q9NPR9.

    Polymorphism databases

    DMDMi 296439338.

    Proteomic databases

    MaxQBi Q9NPR9.
    PaxDbi Q9NPR9.
    PRIDEi Q9NPR9.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000264080 ; ENSP00000264080 ; ENSG00000125734 .
    GeneIDi 56927.
    KEGGi hsa:56927.
    UCSCi uc002mfp.3. human.

    Organism-specific databases

    CTDi 56927.
    GeneCardsi GC19M006729.
    HGNCi HGNC:17829. GPR108.
    HPAi HPA041924.
    HPA041951.
    neXtProti NX_Q9NPR9.
    PharmGKBi PA28855.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG294185.
    HOGENOMi HOG000238447.
    HOVERGENi HBG056147.
    InParanoidi Q9NPR9.
    OMAi VMHYITH.
    OrthoDBi EOG7D85WF.
    PhylomeDBi Q9NPR9.
    TreeFami TF314804.

    Miscellaneous databases

    ChiTaRSi GPR108. human.
    GenomeRNAii 56927.
    NextBioi 62448.
    PROi Q9NPR9.

    Gene expression databases

    ArrayExpressi Q9NPR9.
    Bgeei Q9NPR9.
    CleanExi HS_GPR108.
    Genevestigatori Q9NPR9.

    Family and domain databases

    InterProi IPR009637. TM_rcpt_euk.
    [Graphical view ]
    PANTHERi PTHR21229. PTHR21229. 1 hit.
    Pfami PF06814. Lung_7-TM_R. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The DNA sequence and biology of human chromosome 19."
      Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
      , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
      Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT ARG-36.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    4. The European IMAGE consortium
      Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 8-543, VARIANT ARG-36.

    Entry informationi

    Entry nameiGP108_HUMAN
    AccessioniPrimary (citable) accession number: Q9NPR9
    Secondary accession number(s): B9EJD7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 20, 2005
    Last sequence update: May 18, 2010
    Last modified: October 1, 2014
    This is version 77 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3