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Q9NPR9 (GP108_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 74. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein GPR108
Alternative name(s):
Lung seven transmembrane receptor 2
Gene names
Name:GPR108
Synonyms:LUSTR2
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length543 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Subcellular location

Membrane; Multi-pass membrane protein Potential.

Sequence similarities

Belongs to the LU7TM family.

Ontologies

Keywords
   Cellular componentMembrane
   Coding sequence diversityPolymorphism
   DomainSignal
Transmembrane
Transmembrane helix
   PTMGlycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 3232 Potential
Chain33 – 543511Protein GPR108
PRO_0000045083

Regions

Transmembrane263 – 28321Helical; Name=1; Potential
Transmembrane292 – 31221Helical; Name=2; Potential
Transmembrane336 – 35621Helical; Name=3; Potential
Transmembrane367 – 38721Helical; Name=4; Potential
Transmembrane401 – 42121Helical; Name=5; Potential
Transmembrane449 – 46921Helical; Name=6; Potential
Transmembrane473 – 49321Helical; Name=7; Potential

Amino acid modifications

Glycosylation571N-linked (GlcNAc...) Potential
Glycosylation1091N-linked (GlcNAc...) Potential
Glycosylation2001N-linked (GlcNAc...) Potential
Glycosylation2041N-linked (GlcNAc...) Potential
Glycosylation2281N-linked (GlcNAc...) Potential
Glycosylation5341N-linked (GlcNAc...) Potential

Natural variations

Natural variant361Q → R. Ref.2 Ref.4
Corresponds to variant rs340138 [ dbSNP | Ensembl ].
VAR_060483
Natural variant791L → P.
Corresponds to variant rs4807897 [ dbSNP | Ensembl ].
VAR_056112

Sequences

Sequence LengthMass (Da)Tools
Q9NPR9 [UniParc].

Last modified May 18, 2010. Version 3.
Checksum: 72B853EA61DEF58A

FASTA54360,633
        10         20         30         40         50         60 
MAVSERRGLG RGSPAEWGQR LLLVLLLGGC SGRIHQLALT GEKRADIQLN SFGFYTNGSL 

        70         80         90        100        110        120 
EVELSVLRLG LREAEEKSLL VGFSLSRVRS GRVRSYSTRD FQDCPLQKNS SSFLVLFLIN 

       130        140        150        160        170        180 
TKDLQVQVRK YGEQKTLFIF PGLLPEAPSK PGLPKPQATV PRKVDGGGTS AASKPKSTPA 

       190        200        210        220        230        240 
VIQGPSGKDK DLVLGLSHLN NSYNFSFHVV IGSQAEEGQY SLNFHNCNNS VPGKEHPFDI 

       250        260        270        280        290        300 
TVMIREKNPD GFLSAAEMPL FKLYMVMSAC FLAAGIFWVS ILCRNTYSVF KIHWLMAALA 

       310        320        330        340        350        360 
FTKSISLLFH SINYYFINSQ GHPIEGLAVM YYIAHLLKGA LLFITIALIG SGWAFIKYVL 

       370        380        390        400        410        420 
SDKEKKVFGI VIPMQVLANV AYIIIESREE GASDYVLWKE ILFLVDLICC GAILFPVVWS 

       430        440        450        460        470        480 
IRHLQDASGT DGKVAVNLAK LKLFRHYYVM VICYVYFTRI IAILLQVAVP FQWQWLYQLL 

       490        500        510        520        530        540 
VEGSTLAFFV LTGYKFQPTG NNPYLQLPQE DEEDVQMEQV MTDSGFREGL SKVNKTASGR 


ELL 

« Hide

References

[1]"The DNA sequence and biology of human chromosome 19."
Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V. expand/collapse author list , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT ARG-36.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
[4]The European IMAGE consortium
Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 8-543, VARIANT ARG-36.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CH471139 Genomic DNA. Translation: EAW69067.1.
AC008760 Genomic DNA. No translation available.
BC146909 mRNA. Translation: AAI46910.1.
AL365404 mRNA. Translation: CAB96950.1.
RefSeqNP_001073921.1. NM_001080452.1.
UniGeneHs.167641.

3D structure databases

ProteinModelPortalQ9NPR9.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid121254. 2 interactions.
STRING9606.ENSP00000264080.

PTM databases

PhosphoSiteQ9NPR9.

Polymorphism databases

DMDM296439338.

Proteomic databases

PaxDbQ9NPR9.
PRIDEQ9NPR9.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000264080; ENSP00000264080; ENSG00000125734.
GeneID56927.
KEGGhsa:56927.
UCSCuc002mfp.3. human.

Organism-specific databases

CTD56927.
GeneCardsGC19M006729.
HGNCHGNC:17829. GPR108.
HPAHPA041924.
HPA041951.
neXtProtNX_Q9NPR9.
PharmGKBPA28855.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG294185.
HOGENOMHOG000238447.
HOVERGENHBG056147.
InParanoidQ9NPR9.
OMAVMHYITH.
OrthoDBEOG7D85WF.
PhylomeDBQ9NPR9.
TreeFamTF314804.

Gene expression databases

ArrayExpressQ9NPR9.
BgeeQ9NPR9.
CleanExHS_GPR108.
GenevestigatorQ9NPR9.

Family and domain databases

InterProIPR009637. TM_rcpt_euk.
[Graphical view]
PANTHERPTHR21229. PTHR21229. 1 hit.
PfamPF06814. Lung_7-TM_R. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSGPR108. human.
GenomeRNAi56927.
NextBio62448.
PROQ9NPR9.

Entry information

Entry nameGP108_HUMAN
AccessionPrimary (citable) accession number: Q9NPR9
Secondary accession number(s): B9EJD7
Entry history
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: May 18, 2010
Last modified: April 16, 2014
This is version 74 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 19

Human chromosome 19: entries, gene names and cross-references to MIM