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Q9NPR9

- GP108_HUMAN

UniProt

Q9NPR9 - GP108_HUMAN

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Protein
Protein GPR108
Gene
GPR108, LUSTR2
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Protein GPR108
Alternative name(s):
Lung seven transmembrane receptor 2
Gene namesi
Name:GPR108
Synonyms:LUSTR2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:17829. GPR108.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei263 – 28321Helical; Name=1; Reviewed prediction
Add
BLAST
Transmembranei292 – 31221Helical; Name=2; Reviewed prediction
Add
BLAST
Transmembranei336 – 35621Helical; Name=3; Reviewed prediction
Add
BLAST
Transmembranei367 – 38721Helical; Name=4; Reviewed prediction
Add
BLAST
Transmembranei401 – 42121Helical; Name=5; Reviewed prediction
Add
BLAST
Transmembranei449 – 46921Helical; Name=6; Reviewed prediction
Add
BLAST
Transmembranei473 – 49321Helical; Name=7; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA28855.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3232 Reviewed prediction
Add
BLAST
Chaini33 – 543511Protein GPR108
PRO_0000045083Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi57 – 571N-linked (GlcNAc...) Reviewed prediction
Glycosylationi109 – 1091N-linked (GlcNAc...) Reviewed prediction
Glycosylationi200 – 2001N-linked (GlcNAc...) Reviewed prediction
Glycosylationi204 – 2041N-linked (GlcNAc...) Reviewed prediction
Glycosylationi228 – 2281N-linked (GlcNAc...) Reviewed prediction
Glycosylationi534 – 5341N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ9NPR9.
PaxDbiQ9NPR9.
PRIDEiQ9NPR9.

PTM databases

PhosphoSiteiQ9NPR9.

Expressioni

Gene expression databases

ArrayExpressiQ9NPR9.
BgeeiQ9NPR9.
CleanExiHS_GPR108.
GenevestigatoriQ9NPR9.

Organism-specific databases

HPAiHPA041924.
HPA041951.

Interactioni

Protein-protein interaction databases

BioGridi121254. 2 interactions.
STRINGi9606.ENSP00000264080.

Structurei

3D structure databases

ProteinModelPortaliQ9NPR9.

Family & Domainsi

Sequence similaritiesi

Belongs to the LU7TM family.

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG294185.
HOGENOMiHOG000238447.
HOVERGENiHBG056147.
InParanoidiQ9NPR9.
OMAiVMHYITH.
OrthoDBiEOG7D85WF.
PhylomeDBiQ9NPR9.
TreeFamiTF314804.

Family and domain databases

InterProiIPR009637. TM_rcpt_euk.
[Graphical view]
PANTHERiPTHR21229. PTHR21229. 1 hit.
PfamiPF06814. Lung_7-TM_R. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9NPR9-1 [UniParc]FASTAAdd to Basket

« Hide

MAVSERRGLG RGSPAEWGQR LLLVLLLGGC SGRIHQLALT GEKRADIQLN    50
SFGFYTNGSL EVELSVLRLG LREAEEKSLL VGFSLSRVRS GRVRSYSTRD 100
FQDCPLQKNS SSFLVLFLIN TKDLQVQVRK YGEQKTLFIF PGLLPEAPSK 150
PGLPKPQATV PRKVDGGGTS AASKPKSTPA VIQGPSGKDK DLVLGLSHLN 200
NSYNFSFHVV IGSQAEEGQY SLNFHNCNNS VPGKEHPFDI TVMIREKNPD 250
GFLSAAEMPL FKLYMVMSAC FLAAGIFWVS ILCRNTYSVF KIHWLMAALA 300
FTKSISLLFH SINYYFINSQ GHPIEGLAVM YYIAHLLKGA LLFITIALIG 350
SGWAFIKYVL SDKEKKVFGI VIPMQVLANV AYIIIESREE GASDYVLWKE 400
ILFLVDLICC GAILFPVVWS IRHLQDASGT DGKVAVNLAK LKLFRHYYVM 450
VICYVYFTRI IAILLQVAVP FQWQWLYQLL VEGSTLAFFV LTGYKFQPTG 500
NNPYLQLPQE DEEDVQMEQV MTDSGFREGL SKVNKTASGR ELL 543
Length:543
Mass (Da):60,633
Last modified:May 18, 2010 - v3
Checksum:i72B853EA61DEF58A
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti36 – 361Q → R.2 Publications
Corresponds to variant rs340138 [ dbSNP | Ensembl ].
VAR_060483
Natural varianti79 – 791L → P.
Corresponds to variant rs4807897 [ dbSNP | Ensembl ].
VAR_056112

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH471139 Genomic DNA. Translation: EAW69067.1.
AC008760 Genomic DNA. No translation available.
BC146909 mRNA. Translation: AAI46910.1.
AL365404 mRNA. Translation: CAB96950.1.
CCDSiCCDS42479.1.
RefSeqiNP_001073921.1. NM_001080452.1.
UniGeneiHs.167641.

Genome annotation databases

EnsembliENST00000264080; ENSP00000264080; ENSG00000125734.
GeneIDi56927.
KEGGihsa:56927.
UCSCiuc002mfp.3. human.

Polymorphism databases

DMDMi296439338.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH471139 Genomic DNA. Translation: EAW69067.1 .
AC008760 Genomic DNA. No translation available.
BC146909 mRNA. Translation: AAI46910.1 .
AL365404 mRNA. Translation: CAB96950.1 .
CCDSi CCDS42479.1.
RefSeqi NP_001073921.1. NM_001080452.1.
UniGenei Hs.167641.

3D structure databases

ProteinModelPortali Q9NPR9.
ModBasei Search...

Protein-protein interaction databases

BioGridi 121254. 2 interactions.
STRINGi 9606.ENSP00000264080.

PTM databases

PhosphoSitei Q9NPR9.

Polymorphism databases

DMDMi 296439338.

Proteomic databases

MaxQBi Q9NPR9.
PaxDbi Q9NPR9.
PRIDEi Q9NPR9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000264080 ; ENSP00000264080 ; ENSG00000125734 .
GeneIDi 56927.
KEGGi hsa:56927.
UCSCi uc002mfp.3. human.

Organism-specific databases

CTDi 56927.
GeneCardsi GC19M006729.
HGNCi HGNC:17829. GPR108.
HPAi HPA041924.
HPA041951.
neXtProti NX_Q9NPR9.
PharmGKBi PA28855.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG294185.
HOGENOMi HOG000238447.
HOVERGENi HBG056147.
InParanoidi Q9NPR9.
OMAi VMHYITH.
OrthoDBi EOG7D85WF.
PhylomeDBi Q9NPR9.
TreeFami TF314804.

Miscellaneous databases

ChiTaRSi GPR108. human.
GenomeRNAii 56927.
NextBioi 62448.
PROi Q9NPR9.

Gene expression databases

ArrayExpressi Q9NPR9.
Bgeei Q9NPR9.
CleanExi HS_GPR108.
Genevestigatori Q9NPR9.

Family and domain databases

InterProi IPR009637. TM_rcpt_euk.
[Graphical view ]
PANTHERi PTHR21229. PTHR21229. 1 hit.
Pfami PF06814. Lung_7-TM_R. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT ARG-36.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  4. The European IMAGE consortium
    Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 8-543, VARIANT ARG-36.

Entry informationi

Entry nameiGP108_HUMAN
AccessioniPrimary (citable) accession number: Q9NPR9
Secondary accession number(s): B9EJD7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: May 18, 2010
Last modified: July 9, 2014
This is version 76 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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