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Protein

Protein GPR108

Gene

GPR108

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Enzyme and pathway databases

BioCyciZFISH:ENSG00000125734-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein GPR108
Alternative name(s):
Lung seven transmembrane receptor 2
Gene namesi
Name:GPR108
Synonyms:LUSTR2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:17829. GPR108.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei263 – 283Helical; Name=1Sequence analysisAdd BLAST21
Transmembranei292 – 312Helical; Name=2Sequence analysisAdd BLAST21
Transmembranei336 – 356Helical; Name=3Sequence analysisAdd BLAST21
Transmembranei367 – 387Helical; Name=4Sequence analysisAdd BLAST21
Transmembranei401 – 421Helical; Name=5Sequence analysisAdd BLAST21
Transmembranei449 – 469Helical; Name=6Sequence analysisAdd BLAST21
Transmembranei473 – 493Helical; Name=7Sequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000125734.
PharmGKBiPA28855.

Polymorphism and mutation databases

BioMutaiGPR108.
DMDMi296439338.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 32Sequence analysisAdd BLAST32
ChainiPRO_000004508333 – 543Protein GPR108Add BLAST511

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi57N-linked (GlcNAc...)Sequence analysis1
Glycosylationi109N-linked (GlcNAc...)Sequence analysis1
Glycosylationi200N-linked (GlcNAc...)Sequence analysis1
Glycosylationi204N-linked (GlcNAc...)Sequence analysis1
Glycosylationi228N-linked (GlcNAc...)Sequence analysis1
Glycosylationi534N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiQ9NPR9.
MaxQBiQ9NPR9.
PaxDbiQ9NPR9.
PeptideAtlasiQ9NPR9.
PRIDEiQ9NPR9.

PTM databases

iPTMnetiQ9NPR9.
PhosphoSitePlusiQ9NPR9.
SwissPalmiQ9NPR9.

Expressioni

Gene expression databases

BgeeiENSG00000125734.
CleanExiHS_GPR108.
ExpressionAtlasiQ9NPR9. baseline and differential.
GenevisibleiQ9NPR9. HS.

Organism-specific databases

HPAiHPA041924.
HPA041951.
HPA063863.

Interactioni

Protein-protein interaction databases

BioGridi121254. 4 interactors.
IntActiQ9NPR9. 2 interactors.
STRINGi9606.ENSP00000264080.

Structurei

3D structure databases

ProteinModelPortaliQ9NPR9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LU7TM family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2569. Eukaryota.
ENOG410XQAQ. LUCA.
GeneTreeiENSGT00390000008649.
HOGENOMiHOG000238447.
HOVERGENiHBG056147.
InParanoidiQ9NPR9.
OMAiVMHYITH.
OrthoDBiEOG091G05OJ.
PhylomeDBiQ9NPR9.
TreeFamiTF314804.

Family and domain databases

InterProiIPR009637. GPR107-like.
[Graphical view]
PANTHERiPTHR21229. PTHR21229. 1 hit.
PfamiPF06814. Lung_7-TM_R. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9NPR9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVSERRGLG RGSPAEWGQR LLLVLLLGGC SGRIHQLALT GEKRADIQLN
60 70 80 90 100
SFGFYTNGSL EVELSVLRLG LREAEEKSLL VGFSLSRVRS GRVRSYSTRD
110 120 130 140 150
FQDCPLQKNS SSFLVLFLIN TKDLQVQVRK YGEQKTLFIF PGLLPEAPSK
160 170 180 190 200
PGLPKPQATV PRKVDGGGTS AASKPKSTPA VIQGPSGKDK DLVLGLSHLN
210 220 230 240 250
NSYNFSFHVV IGSQAEEGQY SLNFHNCNNS VPGKEHPFDI TVMIREKNPD
260 270 280 290 300
GFLSAAEMPL FKLYMVMSAC FLAAGIFWVS ILCRNTYSVF KIHWLMAALA
310 320 330 340 350
FTKSISLLFH SINYYFINSQ GHPIEGLAVM YYIAHLLKGA LLFITIALIG
360 370 380 390 400
SGWAFIKYVL SDKEKKVFGI VIPMQVLANV AYIIIESREE GASDYVLWKE
410 420 430 440 450
ILFLVDLICC GAILFPVVWS IRHLQDASGT DGKVAVNLAK LKLFRHYYVM
460 470 480 490 500
VICYVYFTRI IAILLQVAVP FQWQWLYQLL VEGSTLAFFV LTGYKFQPTG
510 520 530 540
NNPYLQLPQE DEEDVQMEQV MTDSGFREGL SKVNKTASGR ELL
Length:543
Mass (Da):60,633
Last modified:May 18, 2010 - v3
Checksum:i72B853EA61DEF58A
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06048336Q → R.2 PublicationsCorresponds to variant rs340138dbSNPEnsembl.1
Natural variantiVAR_05611279L → P.Corresponds to variant rs4807897dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH471139 Genomic DNA. Translation: EAW69067.1.
AC008760 Genomic DNA. No translation available.
BC146909 mRNA. Translation: AAI46910.1.
AL365404 mRNA. Translation: CAB96950.1.
CCDSiCCDS42479.1.
RefSeqiNP_001073921.1. NM_001080452.1.
UniGeneiHs.167641.

Genome annotation databases

EnsembliENST00000264080; ENSP00000264080; ENSG00000125734.
GeneIDi56927.
KEGGihsa:56927.
UCSCiuc002mfp.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH471139 Genomic DNA. Translation: EAW69067.1.
AC008760 Genomic DNA. No translation available.
BC146909 mRNA. Translation: AAI46910.1.
AL365404 mRNA. Translation: CAB96950.1.
CCDSiCCDS42479.1.
RefSeqiNP_001073921.1. NM_001080452.1.
UniGeneiHs.167641.

3D structure databases

ProteinModelPortaliQ9NPR9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121254. 4 interactors.
IntActiQ9NPR9. 2 interactors.
STRINGi9606.ENSP00000264080.

PTM databases

iPTMnetiQ9NPR9.
PhosphoSitePlusiQ9NPR9.
SwissPalmiQ9NPR9.

Polymorphism and mutation databases

BioMutaiGPR108.
DMDMi296439338.

Proteomic databases

EPDiQ9NPR9.
MaxQBiQ9NPR9.
PaxDbiQ9NPR9.
PeptideAtlasiQ9NPR9.
PRIDEiQ9NPR9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000264080; ENSP00000264080; ENSG00000125734.
GeneIDi56927.
KEGGihsa:56927.
UCSCiuc002mfp.4. human.

Organism-specific databases

CTDi56927.
GeneCardsiGPR108.
HGNCiHGNC:17829. GPR108.
HPAiHPA041924.
HPA041951.
HPA063863.
neXtProtiNX_Q9NPR9.
OpenTargetsiENSG00000125734.
PharmGKBiPA28855.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2569. Eukaryota.
ENOG410XQAQ. LUCA.
GeneTreeiENSGT00390000008649.
HOGENOMiHOG000238447.
HOVERGENiHBG056147.
InParanoidiQ9NPR9.
OMAiVMHYITH.
OrthoDBiEOG091G05OJ.
PhylomeDBiQ9NPR9.
TreeFamiTF314804.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000125734-MONOMER.

Miscellaneous databases

ChiTaRSiGPR108. human.
GenomeRNAii56927.
PROiQ9NPR9.

Gene expression databases

BgeeiENSG00000125734.
CleanExiHS_GPR108.
ExpressionAtlasiQ9NPR9. baseline and differential.
GenevisibleiQ9NPR9. HS.

Family and domain databases

InterProiIPR009637. GPR107-like.
[Graphical view]
PANTHERiPTHR21229. PTHR21229. 1 hit.
PfamiPF06814. Lung_7-TM_R. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGP108_HUMAN
AccessioniPrimary (citable) accession number: Q9NPR9
Secondary accession number(s): B9EJD7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: May 18, 2010
Last modified: November 2, 2016
This is version 94 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.