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Q9NPR2

- SEM4B_HUMAN

UniProt

Q9NPR2 - SEM4B_HUMAN

Protein

Semaphorin-4B

Gene

SEMA4B

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 124 (01 Oct 2014)
      Sequence version 3 (11 Apr 2003)
      Previous versions | rss
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    Functioni

    Inhibits axonal extension by providing local signals to specify territories inaccessible for growing axons.By similarity

    GO - Molecular functioni

    1. receptor activity Source: InterPro

    GO - Biological processi

    1. cell differentiation Source: UniProtKB-KW
    2. nervous system development Source: UniProtKB-KW

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Differentiation, Neurogenesis

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Semaphorin-4B
    Gene namesi
    Name:SEMA4B
    Synonyms:KIAA1745, SEMAC
    ORF Names:UNQ749/PRO1480
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 15

    Organism-specific databases

    HGNCiHGNC:10730. SEMA4B.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 38381 PublicationAdd
    BLAST
    Chaini39 – 832794Semaphorin-4BPRO_0000032324Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi64 – 641N-linked (GlcNAc...)1 Publication
    Glycosylationi91 – 911N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi115 ↔ 126PROSITE-ProRule annotation
    Disulfide bondi144 ↔ 153PROSITE-ProRule annotation
    Glycosylationi160 – 1601N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi281 ↔ 394PROSITE-ProRule annotation
    Disulfide bondi305 ↔ 354PROSITE-ProRule annotation
    Glycosylationi405 – 4051N-linked (GlcNAc...)1 Publication
    Glycosylationi520 – 5201N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi521 ↔ 538PROSITE-ProRule annotation
    Disulfide bondi606 ↔ 651PROSITE-ProRule annotation
    Glycosylationi625 – 6251N-linked (GlcNAc...)Sequence Analysis
    Modified residuei813 – 8131Phosphoserine1 Publication
    Modified residuei825 – 8251Phosphoserine2 Publications

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Phosphoprotein

    Proteomic databases

    MaxQBiQ9NPR2.
    PaxDbiQ9NPR2.
    PRIDEiQ9NPR2.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9NPR2.
    BgeeiQ9NPR2.
    CleanExiHS_SEMA4B.
    GenevestigatoriQ9NPR2.

    Organism-specific databases

    HPAiHPA013372.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000332204.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9NPR2.
    SMRiQ9NPR2. Positions 41-669.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini39 – 712674ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini734 – 83299CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei713 – 73321HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini42 – 518477SemaPROSITE-ProRule annotationAdd
    BLAST
    Domaini520 – 57455PSIAdd
    BLAST
    Domaini599 – 65860Ig-like C2-typeAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi753 – 77624Pro-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the semaphorin family.Curated
    Contains 1 PSI domain.Curated
    Contains 1 Sema domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG241642.
    HOVERGENiHBG061165.
    InParanoidiQ9NPR2.
    OrthoDBiEOG7ZD1TK.
    PhylomeDBiQ9NPR2.

    Family and domain databases

    Gene3Di2.130.10.10. 1 hit.
    InterProiIPR016201. Plexin-like_fold.
    IPR002165. Plexin_repeat.
    IPR001627. Semap_dom.
    IPR027231. Semaphorin.
    IPR015943. WD40/YVTN_repeat-like_dom.
    [Graphical view]
    PANTHERiPTHR11036. PTHR11036. 1 hit.
    PfamiPF01437. PSI. 1 hit.
    PF01403. Sema. 1 hit.
    [Graphical view]
    SMARTiSM00423. PSI. 1 hit.
    SM00630. Sema. 1 hit.
    [Graphical view]
    SUPFAMiSSF101912. SSF101912. 1 hit.
    SSF103575. SSF103575. 1 hit.
    PROSITEiPS51004. SEMA. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9NPR2-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MGLRSWLAAP WGALPPRPPL LLLLLLLLLL QPPPPTWALS PRISLPLGSE    50
    ERPFLRFEAE HISNYTALLL SRDGRTLYVG AREALFALSS NLSFLPGGEY 100
    QELLWGADAE KKQQCSFKGK DPQRDCQNYI KILLPLSGSH LFTCGTAAFS 150
    PMCTYINMEN FTLARDEKGN VLLEDGKGRC PFDPNFKSTA LVVDGELYTG 200
    TVSSFQGNDP AISRSQSLRP TKTESSLNWL QDPAFVASAY IPESLGSLQG 250
    DDDKIYFFFS ETGQEFEFFE NTIVSRIARI CKGDEGGERV LQQRWTSFLK 300
    AQLLCSRPDD GFPFNVLQDV FTLSPSPQDW RDTLFYGVFT SQWHRGTTEG 350
    SAVCVFTMKD VQRVFSGLYK EVNRETQQWY TVTHPVPTPR PGACITNSAR 400
    ERKINSSLQL PDRVLNFLKD HFLMDGQVRS RMLLLQPQAR YQRVAVHRVP 450
    GLHHTYDVLF LGTGDGRLHK AVSVGPRVHI IEELQIFSSG QPVQNLLLDT 500
    HRGLLYAASH SGVVQVPMAN CSLYRSCGDC LLARDPYCAW SGSSCKHVSL 550
    YQPQLATRPW IQDIEGASAK DLCSASSVVS PSFVPTGEKP CEQVQFQPNT 600
    VNTLACPLLS NLATRLWLRN GAPVNASASC HVLPTGDLLL VGTQQLGEFQ 650
    CWSLEEGFQQ LVASYCPEVV EDGVADQTDE GGSVPVIIST SRVSAPAGGK 700
    ASWGADRSYW KEFLVMCTLF VLAVLLPVLF LLYRHRNSMK VFLKQGECAS 750
    VHPKTCPVVL PPETRPLNGL GPPSTPLDHR GYQSLSDSPP GSRVFTESEK 800
    RPLSIQDSFV EVSPVCPRPR VRLGSEIRDS VV 832
    Length:832
    Mass (Da):92,193
    Last modified:April 11, 2003 - v3
    Checksum:i29D58C1DDD5E1C6B
    GO
    Isoform 2 (identifier: Q9NPR2-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         709-832: YWKEFLVMCT...LGSEIRDSVV → WARTQLLDLSSLYQAVATREDSASSGEIS

    Note: No experimental confirmation available.

    Show »
    Length:737
    Mass (Da):81,403
    Checksum:i017E1684542A7047
    GO

    Sequence cautioni

    The sequence AAQ88758.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.
    The sequence AAR15707.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.
    The sequence BAB15372.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
    The sequence BAB21836.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti160 – 1601N → P in CAB98205. 1 PublicationCurated
    Sequence conflicti565 – 5651E → K in AAH10701. (PubMed:15489334)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti792 – 7921S → A.4 Publications
    VAR_010758

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei709 – 832124YWKEF…RDSVV → WARTQLLDLSSLYQAVATRE DSASSGEIS in isoform 2. 1 PublicationVSP_012460Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY445887 mRNA. Translation: AAR15707.1. Different initiation.
    AB051532 mRNA. Translation: BAB21836.1. Different initiation.
    AY358392 mRNA. Translation: AAQ88758.1. Different initiation.
    AC091167 Genomic DNA. No translation available.
    AL390080 mRNA. Translation: CAB98204.1.
    AL390081 mRNA. Translation: CAB98205.1.
    AL390082 mRNA. Translation: CAB98206.1.
    AK026133 mRNA. Translation: BAB15372.1. Different initiation.
    BC010701 mRNA. Translation: AAH10701.2.
    BC017658 mRNA. Translation: AAH17658.1.
    UniGeneiHs.474935.

    Genome annotation databases

    EnsembliENST00000379122; ENSP00000368417; ENSG00000185033. [Q9NPR2-2]
    UCSCiuc002bpa.3. human. [Q9NPR2-1]

    Polymorphism databases

    DMDMi29840873.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY445887 mRNA. Translation: AAR15707.1 . Different initiation.
    AB051532 mRNA. Translation: BAB21836.1 . Different initiation.
    AY358392 mRNA. Translation: AAQ88758.1 . Different initiation.
    AC091167 Genomic DNA. No translation available.
    AL390080 mRNA. Translation: CAB98204.1 .
    AL390081 mRNA. Translation: CAB98205.1 .
    AL390082 mRNA. Translation: CAB98206.1 .
    AK026133 mRNA. Translation: BAB15372.1 . Different initiation.
    BC010701 mRNA. Translation: AAH10701.2 .
    BC017658 mRNA. Translation: AAH17658.1 .
    UniGenei Hs.474935.

    3D structure databases

    ProteinModelPortali Q9NPR2.
    SMRi Q9NPR2. Positions 41-669.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000332204.

    Polymorphism databases

    DMDMi 29840873.

    Proteomic databases

    MaxQBi Q9NPR2.
    PaxDbi Q9NPR2.
    PRIDEi Q9NPR2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000379122 ; ENSP00000368417 ; ENSG00000185033 . [Q9NPR2-2 ]
    UCSCi uc002bpa.3. human. [Q9NPR2-1 ]

    Organism-specific databases

    GeneCardsi GC15P090703.
    HGNCi HGNC:10730. SEMA4B.
    HPAi HPA013372.
    neXtProti NX_Q9NPR2.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG241642.
    HOVERGENi HBG061165.
    InParanoidi Q9NPR2.
    OrthoDBi EOG7ZD1TK.
    PhylomeDBi Q9NPR2.

    Miscellaneous databases

    PROi Q9NPR2.

    Gene expression databases

    ArrayExpressi Q9NPR2.
    Bgeei Q9NPR2.
    CleanExi HS_SEMA4B.
    Genevestigatori Q9NPR2.

    Family and domain databases

    Gene3Di 2.130.10.10. 1 hit.
    InterProi IPR016201. Plexin-like_fold.
    IPR002165. Plexin_repeat.
    IPR001627. Semap_dom.
    IPR027231. Semaphorin.
    IPR015943. WD40/YVTN_repeat-like_dom.
    [Graphical view ]
    PANTHERi PTHR11036. PTHR11036. 1 hit.
    Pfami PF01437. PSI. 1 hit.
    PF01403. Sema. 1 hit.
    [Graphical view ]
    SMARTi SM00423. PSI. 1 hit.
    SM00630. Sema. 1 hit.
    [Graphical view ]
    SUPFAMi SSF101912. SSF101912. 1 hit.
    SSF103575. SSF103575. 1 hit.
    PROSITEi PS51004. SEMA. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Semaphorin 4b is a novel hypoxia-induced gene over-expressed in human tumors."
      White J.R., Levinson N., Lee S.R., Myers K.A., Harris R.A., Balkwill F., Beard G.L., Naylor S.
      Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT ALA-792.
    2. "Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
      Nagase T., Kikuno R., Hattori A., Kondo Y., Okumura K., Ohara O.
      DNA Res. 7:347-355(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Brain.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ALA-792.
    4. "Analysis of the DNA sequence and duplication history of human chromosome 15."
      Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K., Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N., Abouelleil A.
      , Arachchi H.M., Baradarani L., Birditt B., Bloom S., Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K., DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J., Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E., Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B., Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R., O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M.B., Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S., Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C.
      Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "Signal peptide prediction based on analysis of experimentally verified cleavage sites."
      Zhang Z., Henzel W.J.
      Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 39-53.
    6. The European IMAGE consortium
      Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 160-832 (ISOFORM 1), VARIANT ALA-792.
    7. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 279-832 (ISOFORM 2).
    8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 303-832 (ISOFORM 1), VARIANT ALA-792.
      Tissue: Colon and Pancreas.
    9. "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
      Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E., Moore R.J., Smith R.D.
      J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-64 AND ASN-405.
      Tissue: Plasma.
    10. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
      Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
      Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-813 AND SER-825, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    11. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-825, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.

    Entry informationi

    Entry nameiSEM4B_HUMAN
    AccessioniPrimary (citable) accession number: Q9NPR2
    Secondary accession number(s): Q6UXE3
    , Q8WVP9, Q96FK5, Q9C0B8, Q9H691, Q9NPM8, Q9NPN0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 27, 2001
    Last sequence update: April 11, 2003
    Last modified: October 1, 2014
    This is version 124 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 15
      Human chromosome 15: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3