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Q9NPR2

- SEM4B_HUMAN

UniProt

Q9NPR2 - SEM4B_HUMAN

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Protein

Semaphorin-4B

Gene

SEMA4B

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Inhibits axonal extension by providing local signals to specify territories inaccessible for growing axons.By similarity

GO - Molecular functioni

  1. receptor activity Source: InterPro

GO - Biological processi

  1. cell differentiation Source: UniProtKB-KW
  2. nervous system development Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation, Neurogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Semaphorin-4B
Gene namesi
Name:SEMA4B
Synonyms:KIAA1745, SEMAC
ORF Names:UNQ749/PRO1480
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 15

Organism-specific databases

HGNCiHGNC:10730. SEMA4B.

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: Ensembl
  3. synapse Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 38381 PublicationAdd
BLAST
Chaini39 – 832794Semaphorin-4BPRO_0000032324Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi64 – 641N-linked (GlcNAc...)1 Publication
Glycosylationi91 – 911N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi115 ↔ 126PROSITE-ProRule annotation
Disulfide bondi144 ↔ 153PROSITE-ProRule annotation
Glycosylationi160 – 1601N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi281 ↔ 394PROSITE-ProRule annotation
Disulfide bondi305 ↔ 354PROSITE-ProRule annotation
Glycosylationi405 – 4051N-linked (GlcNAc...)1 Publication
Glycosylationi520 – 5201N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi521 ↔ 538PROSITE-ProRule annotation
Disulfide bondi606 ↔ 651PROSITE-ProRule annotation
Glycosylationi625 – 6251N-linked (GlcNAc...)Sequence Analysis
Modified residuei813 – 8131Phosphoserine1 Publication
Modified residuei825 – 8251Phosphoserine2 Publications

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ9NPR2.
PaxDbiQ9NPR2.
PRIDEiQ9NPR2.

Expressioni

Gene expression databases

BgeeiQ9NPR2.
CleanExiHS_SEMA4B.
ExpressionAtlasiQ9NPR2. baseline and differential.
GenevestigatoriQ9NPR2.

Organism-specific databases

HPAiHPA013372.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000332204.

Structurei

3D structure databases

ProteinModelPortaliQ9NPR2.
SMRiQ9NPR2. Positions 41-669.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini39 – 712674ExtracellularSequence AnalysisAdd
BLAST
Topological domaini734 – 83299CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei713 – 73321HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini42 – 518477SemaPROSITE-ProRule annotationAdd
BLAST
Domaini520 – 57455PSIAdd
BLAST
Domaini599 – 65860Ig-like C2-typeAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi753 – 77624Pro-richAdd
BLAST

Sequence similaritiesi

Belongs to the semaphorin family.Curated
Contains 1 PSI domain.Curated
Contains 1 Sema domain.PROSITE-ProRule annotation

Keywords - Domaini

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG241642.
HOVERGENiHBG061165.
InParanoidiQ9NPR2.
OrthoDBiEOG7ZD1TK.
PhylomeDBiQ9NPR2.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR016201. Plexin-like_fold.
IPR002165. Plexin_repeat.
IPR001627. Semap_dom.
IPR027231. Semaphorin.
IPR015943. WD40/YVTN_repeat-like_dom.
[Graphical view]
PANTHERiPTHR11036. PTHR11036. 1 hit.
PfamiPF01437. PSI. 1 hit.
PF01403. Sema. 1 hit.
[Graphical view]
SMARTiSM00423. PSI. 1 hit.
SM00630. Sema. 1 hit.
[Graphical view]
SUPFAMiSSF101912. SSF101912. 1 hit.
SSF103575. SSF103575. 1 hit.
PROSITEiPS51004. SEMA. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9NPR2-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGLRSWLAAP WGALPPRPPL LLLLLLLLLL QPPPPTWALS PRISLPLGSE
60 70 80 90 100
ERPFLRFEAE HISNYTALLL SRDGRTLYVG AREALFALSS NLSFLPGGEY
110 120 130 140 150
QELLWGADAE KKQQCSFKGK DPQRDCQNYI KILLPLSGSH LFTCGTAAFS
160 170 180 190 200
PMCTYINMEN FTLARDEKGN VLLEDGKGRC PFDPNFKSTA LVVDGELYTG
210 220 230 240 250
TVSSFQGNDP AISRSQSLRP TKTESSLNWL QDPAFVASAY IPESLGSLQG
260 270 280 290 300
DDDKIYFFFS ETGQEFEFFE NTIVSRIARI CKGDEGGERV LQQRWTSFLK
310 320 330 340 350
AQLLCSRPDD GFPFNVLQDV FTLSPSPQDW RDTLFYGVFT SQWHRGTTEG
360 370 380 390 400
SAVCVFTMKD VQRVFSGLYK EVNRETQQWY TVTHPVPTPR PGACITNSAR
410 420 430 440 450
ERKINSSLQL PDRVLNFLKD HFLMDGQVRS RMLLLQPQAR YQRVAVHRVP
460 470 480 490 500
GLHHTYDVLF LGTGDGRLHK AVSVGPRVHI IEELQIFSSG QPVQNLLLDT
510 520 530 540 550
HRGLLYAASH SGVVQVPMAN CSLYRSCGDC LLARDPYCAW SGSSCKHVSL
560 570 580 590 600
YQPQLATRPW IQDIEGASAK DLCSASSVVS PSFVPTGEKP CEQVQFQPNT
610 620 630 640 650
VNTLACPLLS NLATRLWLRN GAPVNASASC HVLPTGDLLL VGTQQLGEFQ
660 670 680 690 700
CWSLEEGFQQ LVASYCPEVV EDGVADQTDE GGSVPVIIST SRVSAPAGGK
710 720 730 740 750
ASWGADRSYW KEFLVMCTLF VLAVLLPVLF LLYRHRNSMK VFLKQGECAS
760 770 780 790 800
VHPKTCPVVL PPETRPLNGL GPPSTPLDHR GYQSLSDSPP GSRVFTESEK
810 820 830
RPLSIQDSFV EVSPVCPRPR VRLGSEIRDS VV
Length:832
Mass (Da):92,193
Last modified:April 11, 2003 - v3
Checksum:i29D58C1DDD5E1C6B
GO
Isoform 2 (identifier: Q9NPR2-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     709-832: YWKEFLVMCT...LGSEIRDSVV → WARTQLLDLSSLYQAVATREDSASSGEIS

Note: No experimental confirmation available.

Show »
Length:737
Mass (Da):81,403
Checksum:i017E1684542A7047
GO

Sequence cautioni

The sequence AAQ88758.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.
The sequence AAR15707.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.
The sequence BAB15372.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
The sequence BAB21836.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti160 – 1601N → P in CAB98205. 1 PublicationCurated
Sequence conflicti565 – 5651E → K in AAH10701. (PubMed:15489334)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti792 – 7921S → A.4 Publications
VAR_010758

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei709 – 832124YWKEF…RDSVV → WARTQLLDLSSLYQAVATRE DSASSGEIS in isoform 2. 1 PublicationVSP_012460Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY445887 mRNA. Translation: AAR15707.1. Different initiation.
AB051532 mRNA. Translation: BAB21836.1. Different initiation.
AY358392 mRNA. Translation: AAQ88758.1. Different initiation.
AC091167 Genomic DNA. No translation available.
AL390080 mRNA. Translation: CAB98204.1.
AL390081 mRNA. Translation: CAB98205.1.
AL390082 mRNA. Translation: CAB98206.1.
AK026133 mRNA. Translation: BAB15372.1. Different initiation.
BC010701 mRNA. Translation: AAH10701.2.
BC017658 mRNA. Translation: AAH17658.1.
UniGeneiHs.474935.

Genome annotation databases

EnsembliENST00000379122; ENSP00000368417; ENSG00000185033.
UCSCiuc002bpa.3. human. [Q9NPR2-1]

Polymorphism databases

DMDMi29840873.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY445887 mRNA. Translation: AAR15707.1 . Different initiation.
AB051532 mRNA. Translation: BAB21836.1 . Different initiation.
AY358392 mRNA. Translation: AAQ88758.1 . Different initiation.
AC091167 Genomic DNA. No translation available.
AL390080 mRNA. Translation: CAB98204.1 .
AL390081 mRNA. Translation: CAB98205.1 .
AL390082 mRNA. Translation: CAB98206.1 .
AK026133 mRNA. Translation: BAB15372.1 . Different initiation.
BC010701 mRNA. Translation: AAH10701.2 .
BC017658 mRNA. Translation: AAH17658.1 .
UniGenei Hs.474935.

3D structure databases

ProteinModelPortali Q9NPR2.
SMRi Q9NPR2. Positions 41-669.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000332204.

Polymorphism databases

DMDMi 29840873.

Proteomic databases

MaxQBi Q9NPR2.
PaxDbi Q9NPR2.
PRIDEi Q9NPR2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000379122 ; ENSP00000368417 ; ENSG00000185033 .
UCSCi uc002bpa.3. human. [Q9NPR2-1 ]

Organism-specific databases

GeneCardsi GC15P090703.
HGNCi HGNC:10730. SEMA4B.
HPAi HPA013372.
neXtProti NX_Q9NPR2.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG241642.
HOVERGENi HBG061165.
InParanoidi Q9NPR2.
OrthoDBi EOG7ZD1TK.
PhylomeDBi Q9NPR2.

Miscellaneous databases

PROi Q9NPR2.

Gene expression databases

Bgeei Q9NPR2.
CleanExi HS_SEMA4B.
ExpressionAtlasi Q9NPR2. baseline and differential.
Genevestigatori Q9NPR2.

Family and domain databases

Gene3Di 2.130.10.10. 1 hit.
InterProi IPR016201. Plexin-like_fold.
IPR002165. Plexin_repeat.
IPR001627. Semap_dom.
IPR027231. Semaphorin.
IPR015943. WD40/YVTN_repeat-like_dom.
[Graphical view ]
PANTHERi PTHR11036. PTHR11036. 1 hit.
Pfami PF01437. PSI. 1 hit.
PF01403. Sema. 1 hit.
[Graphical view ]
SMARTi SM00423. PSI. 1 hit.
SM00630. Sema. 1 hit.
[Graphical view ]
SUPFAMi SSF101912. SSF101912. 1 hit.
SSF103575. SSF103575. 1 hit.
PROSITEi PS51004. SEMA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Semaphorin 4b is a novel hypoxia-induced gene over-expressed in human tumors."
    White J.R., Levinson N., Lee S.R., Myers K.A., Harris R.A., Balkwill F., Beard G.L., Naylor S.
    Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT ALA-792.
  2. "Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Kikuno R., Hattori A., Kondo Y., Okumura K., Ohara O.
    DNA Res. 7:347-355(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ALA-792.
  4. "Analysis of the DNA sequence and duplication history of human chromosome 15."
    Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K., Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N., Abouelleil A.
    , Arachchi H.M., Baradarani L., Birditt B., Bloom S., Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K., DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J., Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E., Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B., Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R., O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M.B., Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S., Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C.
    Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "Signal peptide prediction based on analysis of experimentally verified cleavage sites."
    Zhang Z., Henzel W.J.
    Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 39-53.
  6. The European IMAGE consortium
    Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 160-832 (ISOFORM 1), VARIANT ALA-792.
  7. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 279-832 (ISOFORM 2).
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 303-832 (ISOFORM 1), VARIANT ALA-792.
    Tissue: Colon and Pancreas.
  9. "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
    Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E., Moore R.J., Smith R.D.
    J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-64 AND ASN-405.
    Tissue: Plasma.
  10. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
    Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
    Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-813 AND SER-825, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  11. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-825, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.

Entry informationi

Entry nameiSEM4B_HUMAN
AccessioniPrimary (citable) accession number: Q9NPR2
Secondary accession number(s): Q6UXE3
, Q8WVP9, Q96FK5, Q9C0B8, Q9H691, Q9NPM8, Q9NPN0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: April 11, 2003
Last modified: October 29, 2014
This is version 125 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3