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Protein

Semaphorin-4B

Gene

SEMA4B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Inhibits axonal extension by providing local signals to specify territories inaccessible for growing axons.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation, Neurogenesis

Enzyme and pathway databases

BioCyciZFISH:G66-32935-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Semaphorin-4B
Gene namesi
Name:SEMA4B
Synonyms:KIAA1745, SEMAC
ORF Names:UNQ749/PRO1480
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Organism-specific databases

HGNCiHGNC:10730. SEMA4B.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini39 – 712ExtracellularSequence analysisAdd BLAST674
Transmembranei713 – 733HelicalSequence analysisAdd BLAST21
Topological domaini734 – 832CytoplasmicSequence analysisAdd BLAST99

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi10509.

Polymorphism and mutation databases

DMDMi29840873.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 381 PublicationAdd BLAST38
ChainiPRO_000003232439 – 832Semaphorin-4BAdd BLAST794

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi64N-linked (GlcNAc...)1 Publication1
Glycosylationi91N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi115 ↔ 126PROSITE-ProRule annotation
Disulfide bondi144 ↔ 153PROSITE-ProRule annotation
Glycosylationi160N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi281 ↔ 394PROSITE-ProRule annotation
Disulfide bondi305 ↔ 354PROSITE-ProRule annotation
Glycosylationi405N-linked (GlcNAc...)1 Publication1
Glycosylationi520N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi521 ↔ 538PROSITE-ProRule annotation
Disulfide bondi606 ↔ 651PROSITE-ProRule annotation
Glycosylationi625N-linked (GlcNAc...)Sequence analysis1
Modified residuei788PhosphoserineCombined sources1
Modified residuei813PhosphoserineCombined sources1
Modified residuei825PhosphoserineCombined sources1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

EPDiQ9NPR2.
MaxQBiQ9NPR2.
PaxDbiQ9NPR2.
PeptideAtlasiQ9NPR2.
PRIDEiQ9NPR2.

PTM databases

iPTMnetiQ9NPR2.
PhosphoSitePlusiQ9NPR2.

Expressioni

Gene expression databases

BgeeiENSG00000185033.
CleanExiHS_SEMA4B.

Organism-specific databases

HPAiHPA013372.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9606.ENSP00000332204.

Structurei

3D structure databases

ProteinModelPortaliQ9NPR2.
SMRiQ9NPR2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini42 – 518SemaPROSITE-ProRule annotationAdd BLAST477
Domaini520 – 574PSIAdd BLAST55
Domaini599 – 658Ig-like C2-typeAdd BLAST60

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi753 – 776Pro-richAdd BLAST24

Sequence similaritiesi

Belongs to the semaphorin family.Curated
Contains 1 PSI domain.Curated
Contains 1 Sema domain.PROSITE-ProRule annotation

Keywords - Domaini

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3611. Eukaryota.
ENOG410XQZC. LUCA.
HOVERGENiHBG061165.
InParanoidiQ9NPR2.
KOiK06521.
PhylomeDBiQ9NPR2.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR002165. Plexin_repeat.
IPR016201. PSI.
IPR001627. Semap_dom.
IPR027231. Semaphorin.
IPR015943. WD40/YVTN_repeat-like_dom.
[Graphical view]
PANTHERiPTHR11036. PTHR11036. 1 hit.
PfamiPF01437. PSI. 1 hit.
PF01403. Sema. 1 hit.
[Graphical view]
SMARTiSM00423. PSI. 1 hit.
SM00630. Sema. 1 hit.
[Graphical view]
SUPFAMiSSF101912. SSF101912. 1 hit.
PROSITEiPS51004. SEMA. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9NPR2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGLRSWLAAP WGALPPRPPL LLLLLLLLLL QPPPPTWALS PRISLPLGSE
60 70 80 90 100
ERPFLRFEAE HISNYTALLL SRDGRTLYVG AREALFALSS NLSFLPGGEY
110 120 130 140 150
QELLWGADAE KKQQCSFKGK DPQRDCQNYI KILLPLSGSH LFTCGTAAFS
160 170 180 190 200
PMCTYINMEN FTLARDEKGN VLLEDGKGRC PFDPNFKSTA LVVDGELYTG
210 220 230 240 250
TVSSFQGNDP AISRSQSLRP TKTESSLNWL QDPAFVASAY IPESLGSLQG
260 270 280 290 300
DDDKIYFFFS ETGQEFEFFE NTIVSRIARI CKGDEGGERV LQQRWTSFLK
310 320 330 340 350
AQLLCSRPDD GFPFNVLQDV FTLSPSPQDW RDTLFYGVFT SQWHRGTTEG
360 370 380 390 400
SAVCVFTMKD VQRVFSGLYK EVNRETQQWY TVTHPVPTPR PGACITNSAR
410 420 430 440 450
ERKINSSLQL PDRVLNFLKD HFLMDGQVRS RMLLLQPQAR YQRVAVHRVP
460 470 480 490 500
GLHHTYDVLF LGTGDGRLHK AVSVGPRVHI IEELQIFSSG QPVQNLLLDT
510 520 530 540 550
HRGLLYAASH SGVVQVPMAN CSLYRSCGDC LLARDPYCAW SGSSCKHVSL
560 570 580 590 600
YQPQLATRPW IQDIEGASAK DLCSASSVVS PSFVPTGEKP CEQVQFQPNT
610 620 630 640 650
VNTLACPLLS NLATRLWLRN GAPVNASASC HVLPTGDLLL VGTQQLGEFQ
660 670 680 690 700
CWSLEEGFQQ LVASYCPEVV EDGVADQTDE GGSVPVIIST SRVSAPAGGK
710 720 730 740 750
ASWGADRSYW KEFLVMCTLF VLAVLLPVLF LLYRHRNSMK VFLKQGECAS
760 770 780 790 800
VHPKTCPVVL PPETRPLNGL GPPSTPLDHR GYQSLSDSPP GSRVFTESEK
810 820 830
RPLSIQDSFV EVSPVCPRPR VRLGSEIRDS VV
Length:832
Mass (Da):92,193
Last modified:April 11, 2003 - v3
Checksum:i29D58C1DDD5E1C6B
GO
Isoform 2 (identifier: Q9NPR2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     709-832: YWKEFLVMCT...LGSEIRDSVV → WARTQLLDLSSLYQAVATREDSASSGEIS

Note: No experimental confirmation available.
Show »
Length:737
Mass (Da):81,403
Checksum:i017E1684542A7047
GO

Sequence cautioni

The sequence AAQ88758 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence AAR15707 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence BAB15372 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAB21836 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti160N → P in CAB98205 (Ref. 6) Curated1
Sequence conflicti565E → K in AAH10701 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_010758792S → A.4 Publications1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_012460709 – 832YWKEF…RDSVV → WARTQLLDLSSLYQAVATRE DSASSGEIS in isoform 2. 1 PublicationAdd BLAST124

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY445887 mRNA. Translation: AAR15707.1. Different initiation.
AB051532 mRNA. Translation: BAB21836.1. Different initiation.
AY358392 mRNA. Translation: AAQ88758.1. Different initiation.
AC091167 Genomic DNA. No translation available.
AL390080 mRNA. Translation: CAB98204.1.
AL390081 mRNA. Translation: CAB98205.1.
AL390082 mRNA. Translation: CAB98206.1.
AK026133 mRNA. Translation: BAB15372.1. Different initiation.
BC010701 mRNA. Translation: AAH10701.2.
BC017658 mRNA. Translation: AAH17658.1.
RefSeqiNP_064595.2. NM_020210.3.
NP_945119.1. NM_198925.2.
UniGeneiHs.474935.

Genome annotation databases

EnsembliENST00000379122; ENSP00000368417; ENSG00000185033.
GeneIDi10509.
KEGGihsa:10509.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY445887 mRNA. Translation: AAR15707.1. Different initiation.
AB051532 mRNA. Translation: BAB21836.1. Different initiation.
AY358392 mRNA. Translation: AAQ88758.1. Different initiation.
AC091167 Genomic DNA. No translation available.
AL390080 mRNA. Translation: CAB98204.1.
AL390081 mRNA. Translation: CAB98205.1.
AL390082 mRNA. Translation: CAB98206.1.
AK026133 mRNA. Translation: BAB15372.1. Different initiation.
BC010701 mRNA. Translation: AAH10701.2.
BC017658 mRNA. Translation: AAH17658.1.
RefSeqiNP_064595.2. NM_020210.3.
NP_945119.1. NM_198925.2.
UniGeneiHs.474935.

3D structure databases

ProteinModelPortaliQ9NPR2.
SMRiQ9NPR2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000332204.

PTM databases

iPTMnetiQ9NPR2.
PhosphoSitePlusiQ9NPR2.

Polymorphism and mutation databases

DMDMi29840873.

Proteomic databases

EPDiQ9NPR2.
MaxQBiQ9NPR2.
PaxDbiQ9NPR2.
PeptideAtlasiQ9NPR2.
PRIDEiQ9NPR2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000379122; ENSP00000368417; ENSG00000185033.
GeneIDi10509.
KEGGihsa:10509.

Organism-specific databases

CTDi10509.
DisGeNETi10509.
GeneCardsiSEMA4B.
HGNCiHGNC:10730. SEMA4B.
HPAiHPA013372.
neXtProtiNX_Q9NPR2.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3611. Eukaryota.
ENOG410XQZC. LUCA.
HOVERGENiHBG061165.
InParanoidiQ9NPR2.
KOiK06521.
PhylomeDBiQ9NPR2.

Enzyme and pathway databases

BioCyciZFISH:G66-32935-MONOMER.

Miscellaneous databases

ChiTaRSiSEMA4B. human.
GenomeRNAii10509.
PROiQ9NPR2.

Gene expression databases

BgeeiENSG00000185033.
CleanExiHS_SEMA4B.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR002165. Plexin_repeat.
IPR016201. PSI.
IPR001627. Semap_dom.
IPR027231. Semaphorin.
IPR015943. WD40/YVTN_repeat-like_dom.
[Graphical view]
PANTHERiPTHR11036. PTHR11036. 1 hit.
PfamiPF01437. PSI. 1 hit.
PF01403. Sema. 1 hit.
[Graphical view]
SMARTiSM00423. PSI. 1 hit.
SM00630. Sema. 1 hit.
[Graphical view]
SUPFAMiSSF101912. SSF101912. 1 hit.
PROSITEiPS51004. SEMA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSEM4B_HUMAN
AccessioniPrimary (citable) accession number: Q9NPR2
Secondary accession number(s): Q6UXE3
, Q8WVP9, Q96FK5, Q9C0B8, Q9H691, Q9NPM8, Q9NPN0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: April 11, 2003
Last modified: November 30, 2016
This is version 141 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.