Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q9NPP4

- NLRC4_HUMAN

UniProt

Q9NPP4 - NLRC4_HUMAN

Protein

NLR family CARD domain-containing protein 4

Gene

NLRC4

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 130 (01 Oct 2014)
      Sequence version 2 (31 Jan 2002)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Key component of inflammasomes that indirectly senses specific proteins from pathogenic bacteria and fungi and responds by assembling an inflammasome complex that promotes caspase-1 activation, cytokine production and macrophage pyroptosis.1 Publication

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi169 – 1768ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: HGNC
    2. identical protein binding Source: IntAct
    3. magnesium ion binding Source: HGNC
    4. protein binding Source: UniProtKB
    5. protein homodimerization activity Source: HGNC

    GO - Biological processi

    1. activation of cysteine-type endopeptidase activity involved in apoptotic process Source: HGNC
    2. activation of innate immune response Source: UniProtKB
    3. defense response to bacterium Source: HGNC
    4. detection of bacterium Source: HGNC
    5. inflammatory response Source: UniProtKB
    6. innate immune response Source: Reactome
    7. interleukin-1 beta secretion Source: HGNC
    8. nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway Source: Reactome
    9. positive regulation of apoptotic process Source: UniProtKB
    10. positive regulation of NF-kappaB transcription factor activity Source: UniProtKB
    11. protein homooligomerization Source: UniProtKB
    12. pyroptosis Source: UniProtKB

    Keywords - Biological processi

    Apoptosis, Immunity, Inflammatory response, Innate immunity

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    ReactomeiREACT_75892. The IPAF inflammasome.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    NLR family CARD domain-containing protein 4
    Alternative name(s):
    CARD, LRR, and NACHT-containing protein
    Short name:
    Clan protein
    Caspase recruitment domain-containing protein 12
    Ice protease-activating factor
    Short name:
    Ipaf
    Gene namesi
    Name:NLRC4
    Synonyms:CARD12, CLAN, CLAN1, IPAF
    ORF Names:UNQ6189/PRO20215
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 2

    Organism-specific databases

    HGNCiHGNC:16412. NLRC4.

    Subcellular locationi

    Cytoplasm 1 Publication. Cytoplasmcytosol By similarity
    Note: Cytoplasmic filaments.

    GO - Cellular componenti

    1. cytosol Source: UniProtKB
    2. intracellular Source: HGNC
    3. IPAF inflammasome complex Source: UniProtKB

    Keywords - Cellular componenti

    Cytoplasm

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA162397671.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 10241024NLR family CARD domain-containing protein 4PRO_0000144087Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei533 – 5331PhosphoserineBy similarity

    Post-translational modificationi

    Phosphorylated at Ser-533 following infection of macrophages with S.typhimurium (Salmonella). Phosphorylation is essential for NLRC4 inflammasome function to promote caspase-1 activation and pyroptosis. PRKCD phosphorylates Ser-533 in vitro By similarity.By similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PaxDbiQ9NPP4.
    PRIDEiQ9NPP4.

    PTM databases

    PhosphoSiteiQ9NPP4.

    Expressioni

    Tissue specificityi

    Isoform 2 is expressed ubiquitously, although highly expressed in lung and spleen. Isoform 1 is highly expressed in lung, followed by leukocytes especially monocytes, lymph node, colon, brain, prostate, placenta, spleen, bone marrow and fetal liver. Isoform 4 is only detected in brain.

    Gene expression databases

    BgeeiQ9NPP4.
    CleanExiHS_NLRC4.
    GenevestigatoriQ9NPP4.

    Organism-specific databases

    HPAiHPA006592.

    Interactioni

    Subunit structurei

    Component of the NLRC4 inflammasome By similarity. Homooligomer. Interacts with ASC, pro-caspase-1, NOD2, BCL10 and NALP1 (NAC) by CARD-CARD interaction. Interacts with EIF2AK2/PKR.By similarity1 Publication

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    itself3EBI-1222527,EBI-1222527
    CASP1P294664EBI-1222527,EBI-516667

    Protein-protein interaction databases

    BioGridi121814. 14 interactions.
    DIPiDIP-38428N.
    IntActiQ9NPP4. 4 interactions.
    MINTiMINT-201147.
    STRINGi9606.ENSP00000354159.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9NPP4.
    SMRiQ9NPP4. Positions 94-1024.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini1 – 8888CARDPROSITE-ProRule annotationAdd
    BLAST
    Domaini163 – 476314NACHTPROSITE-ProRule annotationAdd
    BLAST
    Repeati578 – 59821LRR 1Add
    BLAST
    Repeati656 – 67924LRR 2Add
    BLAST
    Repeati735 – 75824LRR 3Add
    BLAST
    Repeati762 – 78524LRR 4Add
    BLAST
    Repeati787 – 81226LRR 5Add
    BLAST
    Repeati824 – 84724LRR 6Add
    BLAST
    Repeati848 – 87023LRR 7Add
    BLAST
    Repeati878 – 90225LRR 8Add
    BLAST
    Repeati911 – 93323LRR 9Add
    BLAST
    Repeati936 – 96328LRR 10Add
    BLAST
    Repeati965 – 98521LRR 11Add
    BLAST
    Repeati999 – 102123LRR 12Add
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni95 – 298204Nucleotide-binding domain (NBD)By similarityAdd
    BLAST
    Regioni356 – 463108Winged-helix domain (WHD)By similarityAdd
    BLAST

    Domaini

    In an autoinhibited form the C-terminal leucine-rich repeat (LRR) domain is positioned to sterically occlude one side of the NBD domain and consequently sequester NLRC4 in a monomeric state. An ADP-mediated interaction between the NBD and the WHD also contributes to the autoinhibition By similarity.By similarity

    Sequence similaritiesi

    Contains 1 CARD domain.PROSITE-ProRule annotation
    Contains 12 LRR (leucine-rich) repeats.Curated
    Contains 1 NACHT domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Leucine-rich repeat, Repeat

    Phylogenomic databases

    eggNOGiNOG69057.
    HOGENOMiHOG000059630.
    HOVERGENiHBG050790.
    InParanoidiQ9NPP4.
    KOiK12805.
    OMAiIGEGMDY.
    OrthoDBiEOG73BVBV.
    PhylomeDBiQ9NPP4.
    TreeFamiTF336864.

    Family and domain databases

    Gene3Di1.10.533.10. 1 hit.
    InterProiIPR001315. CARD.
    IPR011029. DEATH-like_dom.
    IPR007111. NACHT_NTPase.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF00619. CARD. 1 hit.
    [Graphical view]
    SUPFAMiSSF47986. SSF47986. 1 hit.
    SSF52540. SSF52540. 1 hit.
    PROSITEiPS50209. CARD. 1 hit.
    PS50837. NACHT. 1 hit.
    [Graphical view]

    Sequences (4)i

    Sequence statusi: Complete.

    This entry describes 4 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9NPP4-1) [UniParc]FASTAAdd to Basket

    Also known as: CLANA

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MNFIKDNSRA LIQRMGMTVI KQITDDLFVW NVLNREEVNI ICCEKVEQDA     50
    ARGIIHMILK KGSESCNLFL KSLKEWNYPL FQDLNGQSLF HQTSEGDLDD 100
    LAQDLKDLYH TPSFLNFYPL GEDIDIIFNL KSTFTEPVLW RKDQHHHRVE 150
    QLTLNGLLQA LQSPCIIEGE SGKGKSTLLQ RIAMLWGSGK CKALTKFKFV 200
    FFLRLSRAQG GLFETLCDQL LDIPGTIRKQ TFMAMLLKLR QRVLFLLDGY 250
    NEFKPQNCPE IEALIKENHR FKNMVIVTTT TECLRHIRQF GALTAEVGDM 300
    TEDSAQALIR EVLIKELAEG LLLQIQKSRC LRNLMKTPLF VVITCAIQMG 350
    ESEFHSHTQT TLFHTFYDLL IQKNKHKHKG VAASDFIRSL DHCGDLALEG 400
    VFSHKFDFEL QDVSSVNEDV LLTTGLLCKY TAQRFKPKYK FFHKSFQEYT 450
    AGRRLSSLLT SHEPEEVTKG NGYLQKMVSI SDITSTYSSL LRYTCGSSVE 500
    ATRAVMKHLA AVYQHGCLLG LSIAKRPLWR QESLQSVKNT TEQEILKAIN 550
    INSFVECGIH LYQESTSKSA LSQEFEAFFQ GKSLYINSGN IPDYLFDFFE 600
    HLPNCASALD FIKLDFYGGA MASWEKAAED TGGIHMEEAP ETYIPSRAVS 650
    LFFNWKQEFR TLEVTLRDFS KLNKQDIRYL GKIFSSATSL RLQIKRCAGV 700
    AGSLSLVLST CKNIYSLMVE ASPLTIEDER HITSVTNLKT LSIHDLQNQR 750
    LPGGLTDSLG NLKNLTKLIM DNIKMNEEDA IKLAEGLKNL KKMCLFHLTH 800
    LSDIGEGMDY IVKSLSSEPC DLEEIQLVSC CLSANAVKIL AQNLHNLVKL 850
    SILDLSENYL EKDGNEALHE LIDRMNVLEQ LTALMLPWGC DVQGSLSSLL 900
    KHLEEVPQLV KLGLKNWRLT DTEIRILGAF FGKNPLKNFQ QLNLAGNRVS 950
    SDGWLAFMGV FENLKQLVFF DFSTKEFLPD PALVRKLSQV LSKLTFLQEA 1000
    RLVGWQFDDD DLSVITGAFK LVTA 1024
    Length:1,024
    Mass (Da):116,159
    Last modified:January 31, 2002 - v2
    Checksum:i49378DBB54938E0F
    GO
    Isoform 2 (identifier: Q9NPP4-2) [UniParc]FASTAAdd to Basket

    Also known as: CLANB

    The sequence of this isoform differs from the canonical sequence as follows:
         89-753: Missing.

    Show »
    Length:359
    Mass (Da):40,623
    Checksum:i764417DD658B1DFD
    GO
    Isoform 3 (identifier: Q9NPP4-3) [UniParc]FASTAAdd to Basket

    Also known as: CLANC

    The sequence of this isoform differs from the canonical sequence as follows:
         155-156: NG → VL
         157-1024: Missing.

    Show »
    Length:156
    Mass (Da):18,295
    Checksum:i933CB2315528D67A
    GO
    Isoform 4 (identifier: Q9NPP4-4) [UniParc]FASTAAdd to Basket

    Also known as: CLAND

    The sequence of this isoform differs from the canonical sequence as follows:
         90-92: FHQ → LTA
         93-1024: Missing.

    Show »
    Length:92
    Mass (Da):10,646
    Checksum:iBD090CD064330D1D
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti39 – 391N → D in BAF85362. (PubMed:14702039)Curated
    Sequence conflicti138 – 1381V → I in AAK14776. (PubMed:11472070)Curated
    Sequence conflicti393 – 3931C → R in AAK14776. (PubMed:11472070)Curated
    Sequence conflicti420 – 4201V → A in AAK53443. 1 PublicationCurated
    Sequence conflicti678 – 6781R → T in AAK38730. (PubMed:11374873)Curated
    Sequence conflicti791 – 7911K → E in BAG53062. (PubMed:14702039)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei89 – 753665Missing in isoform 2. 1 PublicationVSP_000784Add
    BLAST
    Alternative sequencei90 – 923FHQ → LTA in isoform 4. 1 PublicationVSP_000787
    Alternative sequencei93 – 1024932Missing in isoform 4. 1 PublicationVSP_000788Add
    BLAST
    Alternative sequencei155 – 1562NG → VL in isoform 3. 1 PublicationVSP_000785
    Alternative sequencei157 – 1024868Missing in isoform 3. 1 PublicationVSP_000786Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY032589 mRNA. Translation: AAK38730.1.
    AY027787 mRNA. Translation: AAK14776.1.
    AY027788 mRNA. Translation: AAK14777.1.
    AY027789 mRNA. Translation: AAK14778.1.
    AY027790 mRNA. Translation: AAK14779.1.
    AY035391 mRNA. Translation: AAK59843.1.
    AF376061 mRNA. Translation: AAK53443.1.
    AY358152 mRNA. Translation: AAQ88519.1.
    AK095467 mRNA. Translation: BAG53062.1.
    AK292673 mRNA. Translation: BAF85362.1.
    AK314762 mRNA. Translation: BAG37300.1.
    AL121653 Genomic DNA. No translation available.
    CH471053 Genomic DNA. Translation: EAX00452.1.
    CH471053 Genomic DNA. Translation: EAX00453.1.
    CH471053 Genomic DNA. Translation: EAX00454.1.
    CH471053 Genomic DNA. Translation: EAX00455.1.
    BC031555 mRNA. Translation: AAH31555.1.
    AL389934 mRNA. Translation: CAB97523.1.
    CCDSiCCDS33174.1. [Q9NPP4-1]
    RefSeqiNP_001186067.1. NM_001199138.1. [Q9NPP4-1]
    NP_001186068.1. NM_001199139.1. [Q9NPP4-1]
    NP_067032.3. NM_021209.4. [Q9NPP4-1]
    UniGeneiHs.574741.

    Genome annotation databases

    EnsembliENST00000342905; ENSP00000339666; ENSG00000091106. [Q9NPP4-2]
    ENST00000360906; ENSP00000354159; ENSG00000091106. [Q9NPP4-1]
    ENST00000402280; ENSP00000385428; ENSG00000091106. [Q9NPP4-1]
    ENST00000404025; ENSP00000385090; ENSG00000091106. [Q9NPP4-1]
    GeneIDi58484.
    KEGGihsa:58484.
    UCSCiuc002roi.3. human. [Q9NPP4-1]
    uc010ezt.2. human. [Q9NPP4-2]

    Polymorphism databases

    DMDMi20138032.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Web resourcesi

    Atlas of Genetics and Cytogenetics in Oncology and Haematology

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY032589 mRNA. Translation: AAK38730.1 .
    AY027787 mRNA. Translation: AAK14776.1 .
    AY027788 mRNA. Translation: AAK14777.1 .
    AY027789 mRNA. Translation: AAK14778.1 .
    AY027790 mRNA. Translation: AAK14779.1 .
    AY035391 mRNA. Translation: AAK59843.1 .
    AF376061 mRNA. Translation: AAK53443.1 .
    AY358152 mRNA. Translation: AAQ88519.1 .
    AK095467 mRNA. Translation: BAG53062.1 .
    AK292673 mRNA. Translation: BAF85362.1 .
    AK314762 mRNA. Translation: BAG37300.1 .
    AL121653 Genomic DNA. No translation available.
    CH471053 Genomic DNA. Translation: EAX00452.1 .
    CH471053 Genomic DNA. Translation: EAX00453.1 .
    CH471053 Genomic DNA. Translation: EAX00454.1 .
    CH471053 Genomic DNA. Translation: EAX00455.1 .
    BC031555 mRNA. Translation: AAH31555.1 .
    AL389934 mRNA. Translation: CAB97523.1 .
    CCDSi CCDS33174.1. [Q9NPP4-1 ]
    RefSeqi NP_001186067.1. NM_001199138.1. [Q9NPP4-1 ]
    NP_001186068.1. NM_001199139.1. [Q9NPP4-1 ]
    NP_067032.3. NM_021209.4. [Q9NPP4-1 ]
    UniGenei Hs.574741.

    3D structure databases

    ProteinModelPortali Q9NPP4.
    SMRi Q9NPP4. Positions 94-1024.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 121814. 14 interactions.
    DIPi DIP-38428N.
    IntActi Q9NPP4. 4 interactions.
    MINTi MINT-201147.
    STRINGi 9606.ENSP00000354159.

    PTM databases

    PhosphoSitei Q9NPP4.

    Polymorphism databases

    DMDMi 20138032.

    Proteomic databases

    PaxDbi Q9NPP4.
    PRIDEi Q9NPP4.

    Protocols and materials databases

    DNASUi 58484.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000342905 ; ENSP00000339666 ; ENSG00000091106 . [Q9NPP4-2 ]
    ENST00000360906 ; ENSP00000354159 ; ENSG00000091106 . [Q9NPP4-1 ]
    ENST00000402280 ; ENSP00000385428 ; ENSG00000091106 . [Q9NPP4-1 ]
    ENST00000404025 ; ENSP00000385090 ; ENSG00000091106 . [Q9NPP4-1 ]
    GeneIDi 58484.
    KEGGi hsa:58484.
    UCSCi uc002roi.3. human. [Q9NPP4-1 ]
    uc010ezt.2. human. [Q9NPP4-2 ]

    Organism-specific databases

    CTDi 58484.
    GeneCardsi GC02M032449.
    HGNCi HGNC:16412. NLRC4.
    HPAi HPA006592.
    MIMi 606831. gene.
    neXtProti NX_Q9NPP4.
    PharmGKBi PA162397671.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG69057.
    HOGENOMi HOG000059630.
    HOVERGENi HBG050790.
    InParanoidi Q9NPP4.
    KOi K12805.
    OMAi IGEGMDY.
    OrthoDBi EOG73BVBV.
    PhylomeDBi Q9NPP4.
    TreeFami TF336864.

    Enzyme and pathway databases

    Reactomei REACT_75892. The IPAF inflammasome.

    Miscellaneous databases

    GeneWikii NLRC4.
    GenomeRNAii 58484.
    NextBioi 35464642.
    PROi Q9NPP4.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9NPP4.
    CleanExi HS_NLRC4.
    Genevestigatori Q9NPP4.

    Family and domain databases

    Gene3Di 1.10.533.10. 1 hit.
    InterProi IPR001315. CARD.
    IPR011029. DEATH-like_dom.
    IPR007111. NACHT_NTPase.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF00619. CARD. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47986. SSF47986. 1 hit.
    SSF52540. SSF52540. 1 hit.
    PROSITEi PS50209. CARD. 1 hit.
    PS50837. NACHT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    2. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2; 3 AND 4).
      Tissue: Lung.
    3. "Identification of Ipaf, a human caspase-1-activating protein related to Apaf-1."
      Poyet J.-L., Srinivasula S.M., Tnani M., Razmara M., Fernandes-Alnemri T., Alnemri E.S.
      J. Biol. Chem. 276:28309-28313(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), SUBCELLULAR LOCATION.
      Tissue: Leukocyte.
    4. "Differential expression of the caspase recruitment domain protein 12 (CARD12) during monocytic differentiation."
      Gingras M., Qiu J., Margolin J.F.
      Submitted (MAY-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    6. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Thymus and Uterus.
    7. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
      , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
      Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    8. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    9. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Brain, Lung and Testis.
    10. The European IMAGE consortium
      Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 586-1024 (ISOFORM 1).
    11. "Heterotypic interactions among NACHT domains: implications for regulation of innate immune responses."
      Damiano J.S., Oliveira V., Welsh K., Reed J.C.
      Biochem. J. 381:213-219(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    12. Cited for: INTERACTION WITH EIF2AK2.

    Entry informationi

    Entry nameiNLRC4_HUMAN
    AccessioniPrimary (citable) accession number: Q9NPP4
    Secondary accession number(s): A8K9F8
    , B2RBQ3, B3KTF0, D6W580, Q96J81, Q96J82, Q96J83
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 31, 2002
    Last sequence update: January 31, 2002
    Last modified: October 1, 2014
    This is version 130 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 2
      Human chromosome 2: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3