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Q9NPP4 (NLRC4_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 128. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Alt products·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
NLR family CARD domain-containing protein 4
Alternative name(s):
CARD, LRR, and NACHT-containing protein
Short name=Clan protein
Caspase recruitment domain-containing protein 12
Ice protease-activating factor
Short name=Ipaf
Gene names
Name:NLRC4
Synonyms:CARD12, CLAN, CLAN1, IPAF
ORF Names:UNQ6189/PRO20215
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length1024 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Key component of inflammasomes that indirectly senses specific proteins from pathogenic bacteria and fungi and responds by assembling an inflammasome complex that promotes caspase-1 activation, cytokine production and macrophage pyroptosis. Ref.11

Subunit structure

Component of the NLRC4 inflammasome By similarity. Homooligomer. Interacts with ASC, pro-caspase-1, NOD2, BCL10 and NALP1 (NAC) by CARD-CARD interaction. Interacts with EIF2AK2/PKR. Ref.12

Subcellular location

Cytoplasm. Cytoplasmcytosol By similarity. Note: Cytoplasmic filaments. Ref.3

Tissue specificity

Isoform 2 is expressed ubiquitously, although highly expressed in lung and spleen. Isoform 1 is highly expressed in lung, followed by leukocytes especially monocytes, lymph node, colon, brain, prostate, placenta, spleen, bone marrow and fetal liver. Isoform 4 is only detected in brain.

Domain

In an autoinhibited form the C-terminal leucine-rich repeat (LRR) domain is positioned to sterically occlude one side of the NBD domain and consequently sequester NLRC4 in a monomeric state. An ADP-mediated interaction between the NBD and the WHD also contributes to the autoinhibition By similarity.

Post-translational modification

Phosphorylated at Ser-533 following infection of macrophages with S.typhimurium (Salmonella). Phosphorylation is essential for NLRC4 inflammasome function to promote caspase-1 activation and pyroptosis. PRKCD phosphorylates Ser-533 in vitro By similarity.

Sequence similarities

Contains 1 CARD domain.

Contains 12 LRR (leucine-rich) repeats.

Contains 1 NACHT domain.

Ontologies

Keywords
   Biological processApoptosis
Immunity
Inflammatory response
Innate immunity
   Cellular componentCytoplasm
   Coding sequence diversityAlternative splicing
   DomainLeucine-rich repeat
Repeat
   LigandATP-binding
Nucleotide-binding
   PTMPhosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processactivation of cysteine-type endopeptidase activity involved in apoptotic process

Inferred from direct assay PubMed 15030775. Source: HGNC

activation of innate immune response

Inferred from sequence or structural similarity. Source: UniProtKB

defense response to bacterium

Inferred from direct assay Ref.11. Source: HGNC

detection of bacterium

Inferred from direct assay Ref.11. Source: HGNC

inflammatory response

Inferred from sequence or structural similarity. Source: UniProtKB

innate immune response

Traceable author statement. Source: Reactome

interleukin-1 beta secretion

Inferred from direct assay PubMed 15882992. Source: HGNC

nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway

Traceable author statement. Source: Reactome

positive regulation of NF-kappaB transcription factor activity

Inferred from direct assay PubMed 12646168. Source: UniProtKB

positive regulation of apoptotic process

Inferred from direct assay PubMed 12646168. Source: UniProtKB

protein homooligomerization

Inferred from sequence or structural similarity. Source: UniProtKB

pyroptosis

Inferred from sequence or structural similarity. Source: UniProtKB

   Cellular_componentIPAF inflammasome complex

Inferred from sequence or structural similarity. Source: UniProtKB

cytosol

Inferred from sequence or structural similarity. Source: UniProtKB

intracellular

Non-traceable author statement Ref.11. Source: HGNC

   Molecular_functionATP binding

Inferred from direct assay PubMed 15882992. Source: HGNC

identical protein binding

Inferred from physical interaction Ref.1Ref.3. Source: IntAct

magnesium ion binding

Traceable author statement PubMed 15882992. Source: HGNC

protein binding

Inferred from physical interaction Ref.2Ref.12. Source: UniProtKB

protein homodimerization activity

Inferred from direct assay Ref.11. Source: HGNC

Complete GO annotation...

Binary interactions

With

Entry

#Exp.

IntAct

Notes

itself3EBI-1222527,EBI-1222527
CASP1P294664EBI-1222527,EBI-516667

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q9NPP4-1)

Also known as: CLANA;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q9NPP4-2)

Also known as: CLANB;

The sequence of this isoform differs from the canonical sequence as follows:
     89-753: Missing.
Isoform 3 (identifier: Q9NPP4-3)

Also known as: CLANC;

The sequence of this isoform differs from the canonical sequence as follows:
     155-156: NG → VL
     157-1024: Missing.
Isoform 4 (identifier: Q9NPP4-4)

Also known as: CLAND;

The sequence of this isoform differs from the canonical sequence as follows:
     90-92: FHQ → LTA
     93-1024: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 10241024NLR family CARD domain-containing protein 4
PRO_0000144087

Regions

Domain1 – 8888CARD
Domain163 – 476314NACHT
Repeat578 – 59821LRR 1
Repeat656 – 67924LRR 2
Repeat735 – 75824LRR 3
Repeat762 – 78524LRR 4
Repeat787 – 81226LRR 5
Repeat824 – 84724LRR 6
Repeat848 – 87023LRR 7
Repeat878 – 90225LRR 8
Repeat911 – 93323LRR 9
Repeat936 – 96328LRR 10
Repeat965 – 98521LRR 11
Repeat999 – 102123LRR 12
Nucleotide binding169 – 1768ATP Potential
Region95 – 298204Nucleotide-binding domain (NBD) By similarity
Region356 – 463108Winged-helix domain (WHD) By similarity

Amino acid modifications

Modified residue5331Phosphoserine By similarity

Natural variations

Alternative sequence89 – 753665Missing in isoform 2.
VSP_000784
Alternative sequence90 – 923FHQ → LTA in isoform 4.
VSP_000787
Alternative sequence93 – 1024932Missing in isoform 4.
VSP_000788
Alternative sequence155 – 1562NG → VL in isoform 3.
VSP_000785
Alternative sequence157 – 1024868Missing in isoform 3.
VSP_000786

Experimental info

Sequence conflict391N → D in BAF85362. Ref.6
Sequence conflict1381V → I in AAK14776. Ref.2
Sequence conflict3931C → R in AAK14776. Ref.2
Sequence conflict4201V → A in AAK53443. Ref.4
Sequence conflict6781R → T in AAK38730. Ref.1
Sequence conflict7911K → E in BAG53062. Ref.6

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 (CLANA) [UniParc].

Last modified January 31, 2002. Version 2.
Checksum: 49378DBB54938E0F

FASTA1,024116,159
        10         20         30         40         50         60 
MNFIKDNSRA LIQRMGMTVI KQITDDLFVW NVLNREEVNI ICCEKVEQDA ARGIIHMILK 

        70         80         90        100        110        120 
KGSESCNLFL KSLKEWNYPL FQDLNGQSLF HQTSEGDLDD LAQDLKDLYH TPSFLNFYPL 

       130        140        150        160        170        180 
GEDIDIIFNL KSTFTEPVLW RKDQHHHRVE QLTLNGLLQA LQSPCIIEGE SGKGKSTLLQ 

       190        200        210        220        230        240 
RIAMLWGSGK CKALTKFKFV FFLRLSRAQG GLFETLCDQL LDIPGTIRKQ TFMAMLLKLR 

       250        260        270        280        290        300 
QRVLFLLDGY NEFKPQNCPE IEALIKENHR FKNMVIVTTT TECLRHIRQF GALTAEVGDM 

       310        320        330        340        350        360 
TEDSAQALIR EVLIKELAEG LLLQIQKSRC LRNLMKTPLF VVITCAIQMG ESEFHSHTQT 

       370        380        390        400        410        420 
TLFHTFYDLL IQKNKHKHKG VAASDFIRSL DHCGDLALEG VFSHKFDFEL QDVSSVNEDV 

       430        440        450        460        470        480 
LLTTGLLCKY TAQRFKPKYK FFHKSFQEYT AGRRLSSLLT SHEPEEVTKG NGYLQKMVSI 

       490        500        510        520        530        540 
SDITSTYSSL LRYTCGSSVE ATRAVMKHLA AVYQHGCLLG LSIAKRPLWR QESLQSVKNT 

       550        560        570        580        590        600 
TEQEILKAIN INSFVECGIH LYQESTSKSA LSQEFEAFFQ GKSLYINSGN IPDYLFDFFE 

       610        620        630        640        650        660 
HLPNCASALD FIKLDFYGGA MASWEKAAED TGGIHMEEAP ETYIPSRAVS LFFNWKQEFR 

       670        680        690        700        710        720 
TLEVTLRDFS KLNKQDIRYL GKIFSSATSL RLQIKRCAGV AGSLSLVLST CKNIYSLMVE 

       730        740        750        760        770        780 
ASPLTIEDER HITSVTNLKT LSIHDLQNQR LPGGLTDSLG NLKNLTKLIM DNIKMNEEDA 

       790        800        810        820        830        840 
IKLAEGLKNL KKMCLFHLTH LSDIGEGMDY IVKSLSSEPC DLEEIQLVSC CLSANAVKIL 

       850        860        870        880        890        900 
AQNLHNLVKL SILDLSENYL EKDGNEALHE LIDRMNVLEQ LTALMLPWGC DVQGSLSSLL 

       910        920        930        940        950        960 
KHLEEVPQLV KLGLKNWRLT DTEIRILGAF FGKNPLKNFQ QLNLAGNRVS SDGWLAFMGV 

       970        980        990       1000       1010       1020 
FENLKQLVFF DFSTKEFLPD PALVRKLSQV LSKLTFLQEA RLVGWQFDDD DLSVITGAFK 


LVTA 

« Hide

Isoform 2 (CLANB) [UniParc].

Checksum: 764417DD658B1DFD
Show »

FASTA35940,623
Isoform 3 (CLANC) [UniParc].

Checksum: 933CB2315528D67A
Show »

FASTA15618,295
Isoform 4 (CLAND) [UniParc].

Checksum: BD090CD064330D1D
Show »

FASTA9210,646

References

« Hide 'large scale' references
[1]"Human CARD12 is a novel CED4/Apaf-1 family member that induces apoptosis."
Geddes B.J., Wang L., Huang W.-J., Lavellee M., Manji G.A., Brown M., Jurman M., Cao J., Morgenstern J., Merriam S., Glucksmann M.A., DiStefano P.S., Bertin J.
Biochem. Biophys. Res. Commun. 284:77-82(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[2]"CLAN, a novel human CED-4-like gene."
Damiano J.S., Stehlik C., Pio F., Godzik A., Reed J.C.
Genomics 75:77-83(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2; 3 AND 4).
Tissue: Lung.
[3]"Identification of Ipaf, a human caspase-1-activating protein related to Apaf-1."
Poyet J.-L., Srinivasula S.M., Tnani M., Razmara M., Fernandes-Alnemri T., Alnemri E.S.
J. Biol. Chem. 276:28309-28313(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), SUBCELLULAR LOCATION.
Tissue: Leukocyte.
[4]"Differential expression of the caspase recruitment domain protein 12 (CARD12) during monocytic differentiation."
Gingras M., Qiu J., Margolin J.F.
Submitted (MAY-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[5]"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. expand/collapse author list , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.
Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[6]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Thymus and Uterus.
[7]"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. expand/collapse author list , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[8]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[9]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Brain, Lung and Testis.
[10]The European IMAGE consortium
Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 586-1024 (ISOFORM 1).
[11]"Heterotypic interactions among NACHT domains: implications for regulation of innate immune responses."
Damiano J.S., Oliveira V., Welsh K., Reed J.C.
Biochem. J. 381:213-219(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[12]"Novel role of PKR in inflammasome activation and HMGB1 release."
Lu B., Nakamura T., Inouye K., Li J., Tang Y., Lundbaeck P., Valdes-Ferrer S.I., Olofsson P.S., Kalb T., Roth J., Zou Y., Erlandsson-Harris H., Yang H., Ting J.P., Wang H., Andersson U., Antoine D.J., Chavan S.S., Hotamisligil G.S., Tracey K.J.
Nature 488:670-674(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH EIF2AK2.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY032589 mRNA. Translation: AAK38730.1.
AY027787 mRNA. Translation: AAK14776.1.
AY027788 mRNA. Translation: AAK14777.1.
AY027789 mRNA. Translation: AAK14778.1.
AY027790 mRNA. Translation: AAK14779.1.
AY035391 mRNA. Translation: AAK59843.1.
AF376061 mRNA. Translation: AAK53443.1.
AY358152 mRNA. Translation: AAQ88519.1.
AK095467 mRNA. Translation: BAG53062.1.
AK292673 mRNA. Translation: BAF85362.1.
AK314762 mRNA. Translation: BAG37300.1.
AL121653 Genomic DNA. No translation available.
CH471053 Genomic DNA. Translation: EAX00452.1.
CH471053 Genomic DNA. Translation: EAX00453.1.
CH471053 Genomic DNA. Translation: EAX00454.1.
CH471053 Genomic DNA. Translation: EAX00455.1.
BC031555 mRNA. Translation: AAH31555.1.
AL389934 mRNA. Translation: CAB97523.1.
CCDSCCDS33174.1. [Q9NPP4-1]
RefSeqNP_001186067.1. NM_001199138.1. [Q9NPP4-1]
NP_001186068.1. NM_001199139.1. [Q9NPP4-1]
NP_067032.3. NM_021209.4. [Q9NPP4-1]
UniGeneHs.574741.

3D structure databases

ProteinModelPortalQ9NPP4.
SMRQ9NPP4. Positions 94-1024.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid121814. 14 interactions.
DIPDIP-38428N.
IntActQ9NPP4. 4 interactions.
MINTMINT-201147.
STRING9606.ENSP00000354159.

PTM databases

PhosphoSiteQ9NPP4.

Polymorphism databases

DMDM20138032.

Proteomic databases

PaxDbQ9NPP4.
PRIDEQ9NPP4.

Protocols and materials databases

DNASU58484.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000342905; ENSP00000339666; ENSG00000091106. [Q9NPP4-2]
ENST00000360906; ENSP00000354159; ENSG00000091106. [Q9NPP4-1]
ENST00000402280; ENSP00000385428; ENSG00000091106. [Q9NPP4-1]
ENST00000404025; ENSP00000385090; ENSG00000091106. [Q9NPP4-1]
GeneID58484.
KEGGhsa:58484.
UCSCuc002roi.3. human. [Q9NPP4-1]
uc010ezt.2. human. [Q9NPP4-2]

Organism-specific databases

CTD58484.
GeneCardsGC02M032449.
HGNCHGNC:16412. NLRC4.
HPAHPA006592.
MIM606831. gene.
neXtProtNX_Q9NPP4.
PharmGKBPA162397671.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG69057.
HOGENOMHOG000059630.
HOVERGENHBG050790.
InParanoidQ9NPP4.
KOK12805.
OMAIGEGMDY.
OrthoDBEOG73BVBV.
PhylomeDBQ9NPP4.
TreeFamTF336864.

Enzyme and pathway databases

ReactomeREACT_6900. Immune System.

Gene expression databases

BgeeQ9NPP4.
CleanExHS_NLRC4.
GenevestigatorQ9NPP4.

Family and domain databases

Gene3D1.10.533.10. 1 hit.
InterProIPR001315. CARD.
IPR011029. DEATH-like_dom.
IPR007111. NACHT_NTPase.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamPF00619. CARD. 1 hit.
[Graphical view]
SUPFAMSSF47986. SSF47986. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEPS50209. CARD. 1 hit.
PS50837. NACHT. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiNLRC4.
GenomeRNAi58484.
NextBio35464642.
PROQ9NPP4.
SOURCESearch...

Entry information

Entry nameNLRC4_HUMAN
AccessionPrimary (citable) accession number: Q9NPP4
Secondary accession number(s): A8K9F8 expand/collapse secondary AC list , B2RBQ3, B3KTF0, D6W580, Q96J81, Q96J82, Q96J83
Entry history
Integrated into UniProtKB/Swiss-Prot: January 31, 2002
Last sequence update: January 31, 2002
Last modified: July 9, 2014
This is version 128 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 2

Human chromosome 2: entries, gene names and cross-references to MIM