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Q9NPI9 (KCJ16_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 119. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Inward rectifier potassium channel 16
Alternative name(s):
Inward rectifier K(+) channel Kir5.1
Potassium channel, inwardly rectifying subfamily J member 16
Gene names
Name:KCNJ16
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length418 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. KCNJ16 may be involved in the regulation of fluid and pH balance.

Subunit structure

Seems to form heterodimer with Kir4.1/KCNJ10 or Kir2.1/KCNJ2.

Subcellular location

Membrane; Multi-pass membrane protein.

Tissue specificity

Highly expressed in kidney, pancreas and thyroid gland.

Sequence similarities

Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ16 subfamily. [View classification]

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 418418Inward rectifier potassium channel 16
PRO_0000154975

Regions

Topological domain1 – 7070Cytoplasmic By similarity
Transmembrane71 – 9525Helical; Name=M1; By similarity
Topological domain96 – 11722Extracellular By similarity
Intramembrane118 – 12912Helical; Pore-forming; Name=H5; By similarity
Intramembrane130 – 1367Pore-forming; By similarity
Topological domain137 – 1459Extracellular By similarity
Transmembrane146 – 16722Helical; Name=M2; By similarity
Topological domain168 – 418251Cytoplasmic By similarity
Motif131 – 1366Selectivity filter By similarity

Sites

Site1611Role in the control of polyamine-mediated channel gating and in the blocking by intracellular magnesium By similarity

Natural variations

Natural variant111I → V.
Corresponds to variant rs9302912 [ dbSNP | Ensembl ].
VAR_024510

Sequences

Sequence LengthMass (Da)Tools
Q9NPI9 [UniParc].

Last modified October 1, 2000. Version 1.
Checksum: 1E241B4C15CBD264

FASTA41847,949
        10         20         30         40         50         60 
MSYYGSSYHI INADAKYPGY PPEHIIAEKR RARRRLLHKD GSCNVYFKHI FGEWGSYVVD 

        70         80         90        100        110        120 
IFTTLVDTKW RHMFVIFSLS YILSWLIFGS VFWLIAFHHG DLLNDPDITP CVDNVHSFTG 

       130        140        150        160        170        180 
AFLFSLETQT TIGYGYRCVT EECSVAVLMV ILQSILSCII NTFIIGAALA KMATARKRAQ 

       190        200        210        220        230        240 
TIRFSYFALI GMRDGKLCLM WRIGDFRPNH VVEGTVRAQL LRYTEDSEGR MTMAFKDLKL 

       250        260        270        280        290        300 
VNDQIILVTP VTIVHEIDHE SPLYALDRKA VAKDNFEILV TFIYTGDSTG TSHQSRSSYV 

       310        320        330        340        350        360 
PREILWGHRF NDVLEVKRKY YKVNCLQFEG SVEVYAPFCS AKQLDWKDQQ LHIEKAPPVR 

       370        380        390        400        410 
ESCTSDTKAR RRSFSAVAIV SSCENPEETT TSATHEYRET PYQKALLTLN RISVESQM 

« Hide

References

[1]"The human inward rectifier K(+) channel subunit kir5.1 (KCNJ16) maps to chromosome 17q25 and is expressed in kidney and pancreas."
Liu Y., McKenna E., Figueroa D.J., Blevins R., Austin C.P., Bennett P.B., Swanson R.
Cytogenet. Cell Genet. 90:60-63(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Genetic and functional linkage of Kir5.1 and Kir2.1 channel subunits."
Derst C., Karschin C., Wischmeyer E., Hirsch J.R., Preisig-Muller R., Rajan S., Engel H., Grzeschik K., Daut J., Karschin A.
FEBS Lett. 491:305-311(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
Tissue: Kidney and Parathyroid.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF179353 mRNA. Translation: AAG09401.1.
AF153814 Genomic DNA. Translation: AAF73244.1.
AF153815 mRNA. Translation: AAF73238.1.
AF153816 mRNA. Translation: AAF73239.1.
AF153817 mRNA. Translation: AAF73240.1.
CCDSCCDS11687.1.
RefSeqNP_001257351.1. NM_001270422.1.
NP_001278551.1. NM_001291622.1.
NP_001278552.1. NM_001291623.1.
NP_001278553.1. NM_001291624.1.
NP_001278554.1. NM_001291625.1.
NP_061128.2. NM_018658.2.
NP_733937.2. NM_170741.2.
NP_733938.2. NM_170742.2.
XP_006721953.1. XM_006721890.1.
UniGeneHs.463985.

3D structure databases

ProteinModelPortalQ9NPI9.
SMRQ9NPI9. Positions 33-344.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ9NPI9. 2 interactions.
STRING9606.ENSP00000283936.

Protein family/group databases

TCDB1.A.2.1.11. inward rectifier k(+) channel (irk-c) family.

PTM databases

PhosphoSiteQ9NPI9.

Polymorphism databases

DMDM13878562.

Proteomic databases

PaxDbQ9NPI9.
PRIDEQ9NPI9.

Protocols and materials databases

DNASU3773.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000283936; ENSP00000283936; ENSG00000153822.
ENST00000392670; ENSP00000376438; ENSG00000153822.
ENST00000392671; ENSP00000376439; ENSG00000153822.
ENST00000589377; ENSP00000465967; ENSG00000153822.
GeneID3773.
KEGGhsa:3773.
UCSCuc002jin.4. human.

Organism-specific databases

CTD3773.
GeneCardsGC17P068071.
HGNCHGNC:6262. KCNJ16.
HPAHPA059563.
MIM605722. gene.
neXtProtNX_Q9NPI9.
PharmGKBPA30047.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG277052.
HOGENOMHOG000237325.
HOVERGENHBG006178.
InParanoidQ9NPI9.
KOK05009.
OrthoDBEOG7XPZ5K.
PhylomeDBQ9NPI9.
TreeFamTF313676.

Enzyme and pathway databases

ReactomeREACT_13685. Neuronal System.

Gene expression databases

ArrayExpressQ9NPI9.
BgeeQ9NPI9.
CleanExHS_KCNJ16.
GenevestigatorQ9NPI9.

Family and domain databases

Gene3D2.60.40.1400. 1 hit.
InterProIPR014756. Ig_E-set.
IPR016449. K_chnl_inward-rec_Kir.
IPR008061. K_chnl_inward-rec_Kir5.
IPR013518. K_chnl_inward-rec_Kir_cyto.
[Graphical view]
PANTHERPTHR11767. PTHR11767. 1 hit.
PTHR11767:SF24. PTHR11767:SF24. 1 hit.
PfamPF01007. IRK. 1 hit.
[Graphical view]
PIRSFPIRSF005465. GIRK_kir. 1 hit.
PRINTSPR01678. KIR5CHANNEL.
PR01320. KIRCHANNEL.
SUPFAMSSF81296. SSF81296. 1 hit.
ProtoNetSearch...

Other

GeneWikiKCNJ16.
GenomeRNAi3773.
NextBio14799.
PROQ9NPI9.
SOURCESearch...

Entry information

Entry nameKCJ16_HUMAN
AccessionPrimary (citable) accession number: Q9NPI9
Entry history
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: October 1, 2000
Last modified: July 9, 2014
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 17

Human chromosome 17: entries, gene names and cross-references to MIM