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Protein

Inward rectifier potassium channel 16

Gene

KCNJ16

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. KCNJ16 may be involved in the regulation of fluid and pH balance. In the kidney, together with KCNJ10, mediates basolateral K+ recycling in distal tubules; this process is critical for Na+ reabsorption at the tubules (PubMed:24561201).1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei161Role in the control of polyamine-mediated channel gating and in the blocking by intracellular magnesiumBy similarity1

GO - Molecular functioni

GO - Biological processi

  • potassium ion import Source: GO_Central
  • potassium ion transport Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Voltage-gated channel

Keywords - Biological processi

Ion transport, Potassium transport, Transport

Keywords - Ligandi

Potassium

Enzyme and pathway databases

BioCyciZFISH:ENSG00000153822-MONOMER.
ReactomeiR-HSA-1296041. Activation of G protein gated Potassium channels.
R-HSA-1296067. Potassium transport channels.
R-HSA-997272. Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits.

Protein family/group databases

TCDBi1.A.2.1.11. inward rectifier k(+) channel (irk-c) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Inward rectifier potassium channel 16
Alternative name(s):
Inward rectifier K(+) channel Kir5.1
Potassium channel, inwardly rectifying subfamily J member 16
Gene namesi
Name:KCNJ16
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:6262. KCNJ16.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 70CytoplasmicBy similarityAdd BLAST70
Transmembranei71 – 95Helical; Name=M1By similarityAdd BLAST25
Topological domaini96 – 117ExtracellularBy similarityAdd BLAST22
Intramembranei118 – 129Helical; Pore-forming; Name=H5By similarityAdd BLAST12
Intramembranei130 – 136Pore-formingBy similarity7
Topological domaini137 – 145ExtracellularBy similarity9
Transmembranei146 – 167Helical; Name=M2By similarityAdd BLAST22
Topological domaini168 – 418CytoplasmicBy similarityAdd BLAST251

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi3773.
OpenTargetsiENSG00000153822.
PharmGKBiPA30047.

Polymorphism and mutation databases

BioMutaiKCNJ16.
DMDMi13878562.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001549751 – 418Inward rectifier potassium channel 16Add BLAST418

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei373PhosphoserineBy similarity1
Modified residuei375PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9NPI9.
PeptideAtlasiQ9NPI9.
PRIDEiQ9NPI9.

PTM databases

PhosphoSitePlusiQ9NPI9.

Expressioni

Tissue specificityi

Widely expressed, with highest levels in adult and fetal kidney (at protein level). In the kidney, expressed in the proximal and distal convoluted tubules, but not in glomeruli nor collecting ducts.3 Publications

Gene expression databases

BgeeiENSG00000153822.
CleanExiHS_KCNJ16.
ExpressionAtlasiQ9NPI9. baseline and differential.
GenevisibleiQ9NPI9. HS.

Organism-specific databases

HPAiHPA059563.

Interactioni

Subunit structurei

Heterodimer with Kir4.1/KCNJ10; this interaction is required for KCNJ16 localization to the basolateral membrane in kidney cells. As a heterodimer with KCNJ10, may interact with MAGI1; this interaction may facilitate KCNJ10/KCNJ16 potassium channel expression at the basolateral membrane in kidney cells (PubMed:24561201). May form heterodimers with Kir2.1/KCNJ2 (Probable).1 Publication1 Publication

Protein-protein interaction databases

IntActiQ9NPI9. 2 interactors.
STRINGi9606.ENSP00000283936.

Structurei

3D structure databases

ProteinModelPortaliQ9NPI9.
SMRiQ9NPI9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi131 – 136Selectivity filterBy similarity6

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3827. Eukaryota.
ENOG410XQ62. LUCA.
GeneTreeiENSGT00760000118842.
HOGENOMiHOG000237325.
HOVERGENiHBG006178.
InParanoidiQ9NPI9.
KOiK05009.
PhylomeDBiQ9NPI9.
TreeFamiTF313676.

Family and domain databases

Gene3Di2.60.40.1400. 1 hit.
InterProiIPR014756. Ig_E-set.
IPR016449. K_chnl_inward-rec_Kir.
IPR008061. K_chnl_inward-rec_Kir5.
IPR013518. K_chnl_inward-rec_Kir_cyto.
[Graphical view]
PANTHERiPTHR11767. PTHR11767. 1 hit.
PTHR11767:SF24. PTHR11767:SF24. 1 hit.
PfamiPF01007. IRK. 1 hit.
[Graphical view]
PIRSFiPIRSF005465. GIRK_kir. 1 hit.
PRINTSiPR01678. KIR5CHANNEL.
PR01320. KIRCHANNEL.
SUPFAMiSSF81296. SSF81296. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9NPI9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSYYGSSYHI INADAKYPGY PPEHIIAEKR RARRRLLHKD GSCNVYFKHI
60 70 80 90 100
FGEWGSYVVD IFTTLVDTKW RHMFVIFSLS YILSWLIFGS VFWLIAFHHG
110 120 130 140 150
DLLNDPDITP CVDNVHSFTG AFLFSLETQT TIGYGYRCVT EECSVAVLMV
160 170 180 190 200
ILQSILSCII NTFIIGAALA KMATARKRAQ TIRFSYFALI GMRDGKLCLM
210 220 230 240 250
WRIGDFRPNH VVEGTVRAQL LRYTEDSEGR MTMAFKDLKL VNDQIILVTP
260 270 280 290 300
VTIVHEIDHE SPLYALDRKA VAKDNFEILV TFIYTGDSTG TSHQSRSSYV
310 320 330 340 350
PREILWGHRF NDVLEVKRKY YKVNCLQFEG SVEVYAPFCS AKQLDWKDQQ
360 370 380 390 400
LHIEKAPPVR ESCTSDTKAR RRSFSAVAIV SSCENPEETT TSATHEYRET
410
PYQKALLTLN RISVESQM
Length:418
Mass (Da):47,949
Last modified:October 1, 2000 - v1
Checksum:i1E241B4C15CBD264
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02451011I → V.Corresponds to variant rs9302912dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF179353 mRNA. Translation: AAG09401.1.
AF153814 Genomic DNA. Translation: AAF73244.1.
AF153815 mRNA. Translation: AAF73238.1.
AF153816 mRNA. Translation: AAF73239.1.
AF153817 mRNA. Translation: AAF73240.1.
CCDSiCCDS11687.1.
RefSeqiNP_001257351.1. NM_001270422.1.
NP_001278551.1. NM_001291622.1.
NP_001278552.1. NM_001291623.1.
NP_001278553.1. NM_001291624.1.
NP_001278554.1. NM_001291625.1.
NP_061128.2. NM_018658.2.
NP_733937.2. NM_170741.2.
NP_733938.2. NM_170742.2.
XP_011523083.1. XM_011524781.2.
XP_016880102.1. XM_017024613.1.
UniGeneiHs.463985.

Genome annotation databases

EnsembliENST00000283936; ENSP00000283936; ENSG00000153822.
ENST00000392670; ENSP00000376438; ENSG00000153822.
ENST00000392671; ENSP00000376439; ENSG00000153822.
ENST00000589377; ENSP00000465967; ENSG00000153822.
ENST00000615244; ENSP00000479817; ENSG00000153822.
GeneIDi3773.
KEGGihsa:3773.
UCSCiuc002jin.5. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF179353 mRNA. Translation: AAG09401.1.
AF153814 Genomic DNA. Translation: AAF73244.1.
AF153815 mRNA. Translation: AAF73238.1.
AF153816 mRNA. Translation: AAF73239.1.
AF153817 mRNA. Translation: AAF73240.1.
CCDSiCCDS11687.1.
RefSeqiNP_001257351.1. NM_001270422.1.
NP_001278551.1. NM_001291622.1.
NP_001278552.1. NM_001291623.1.
NP_001278553.1. NM_001291624.1.
NP_001278554.1. NM_001291625.1.
NP_061128.2. NM_018658.2.
NP_733937.2. NM_170741.2.
NP_733938.2. NM_170742.2.
XP_011523083.1. XM_011524781.2.
XP_016880102.1. XM_017024613.1.
UniGeneiHs.463985.

3D structure databases

ProteinModelPortaliQ9NPI9.
SMRiQ9NPI9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9NPI9. 2 interactors.
STRINGi9606.ENSP00000283936.

Protein family/group databases

TCDBi1.A.2.1.11. inward rectifier k(+) channel (irk-c) family.

PTM databases

PhosphoSitePlusiQ9NPI9.

Polymorphism and mutation databases

BioMutaiKCNJ16.
DMDMi13878562.

Proteomic databases

PaxDbiQ9NPI9.
PeptideAtlasiQ9NPI9.
PRIDEiQ9NPI9.

Protocols and materials databases

DNASUi3773.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000283936; ENSP00000283936; ENSG00000153822.
ENST00000392670; ENSP00000376438; ENSG00000153822.
ENST00000392671; ENSP00000376439; ENSG00000153822.
ENST00000589377; ENSP00000465967; ENSG00000153822.
ENST00000615244; ENSP00000479817; ENSG00000153822.
GeneIDi3773.
KEGGihsa:3773.
UCSCiuc002jin.5. human.

Organism-specific databases

CTDi3773.
DisGeNETi3773.
GeneCardsiKCNJ16.
HGNCiHGNC:6262. KCNJ16.
HPAiHPA059563.
MIMi605722. gene.
neXtProtiNX_Q9NPI9.
OpenTargetsiENSG00000153822.
PharmGKBiPA30047.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3827. Eukaryota.
ENOG410XQ62. LUCA.
GeneTreeiENSGT00760000118842.
HOGENOMiHOG000237325.
HOVERGENiHBG006178.
InParanoidiQ9NPI9.
KOiK05009.
PhylomeDBiQ9NPI9.
TreeFamiTF313676.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000153822-MONOMER.
ReactomeiR-HSA-1296041. Activation of G protein gated Potassium channels.
R-HSA-1296067. Potassium transport channels.
R-HSA-997272. Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits.

Miscellaneous databases

GeneWikiiKCNJ16.
GenomeRNAii3773.
PROiQ9NPI9.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000153822.
CleanExiHS_KCNJ16.
ExpressionAtlasiQ9NPI9. baseline and differential.
GenevisibleiQ9NPI9. HS.

Family and domain databases

Gene3Di2.60.40.1400. 1 hit.
InterProiIPR014756. Ig_E-set.
IPR016449. K_chnl_inward-rec_Kir.
IPR008061. K_chnl_inward-rec_Kir5.
IPR013518. K_chnl_inward-rec_Kir_cyto.
[Graphical view]
PANTHERiPTHR11767. PTHR11767. 1 hit.
PTHR11767:SF24. PTHR11767:SF24. 1 hit.
PfamiPF01007. IRK. 1 hit.
[Graphical view]
PIRSFiPIRSF005465. GIRK_kir. 1 hit.
PRINTSiPR01678. KIR5CHANNEL.
PR01320. KIRCHANNEL.
SUPFAMiSSF81296. SSF81296. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiKCJ16_HUMAN
AccessioniPrimary (citable) accession number: Q9NPI9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: October 1, 2000
Last modified: November 2, 2016
This is version 138 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.