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Q9NPI9

- KCJ16_HUMAN

UniProt

Q9NPI9 - KCJ16_HUMAN

Protein

Inward rectifier potassium channel 16

Gene

KCNJ16

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 121 (01 Oct 2014)
      Sequence version 1 (01 Oct 2000)
      Previous versions | rss
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    Functioni

    Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. KCNJ16 may be involved in the regulation of fluid and pH balance.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei161 – 1611Role in the control of polyamine-mediated channel gating and in the blocking by intracellular magnesiumBy similarity

    GO - Molecular functioni

    1. inward rectifier potassium channel activity Source: UniProtKB

    GO - Biological processi

    1. potassium ion transmembrane transport Source: GOC
    2. potassium ion transport Source: UniProtKB
    3. synaptic transmission Source: Reactome

    Keywords - Molecular functioni

    Ion channel, Voltage-gated channel

    Keywords - Biological processi

    Ion transport, Potassium transport, Transport

    Keywords - Ligandi

    Potassium

    Enzyme and pathway databases

    ReactomeiREACT_25004. Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits.
    REACT_75815. Potassium transport channels.
    REACT_75831. Activation of G protein gated Potassium channels.

    Protein family/group databases

    TCDBi1.A.2.1.11. inward rectifier k(+) channel (irk-c) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Inward rectifier potassium channel 16
    Alternative name(s):
    Inward rectifier K(+) channel Kir5.1
    Potassium channel, inwardly rectifying subfamily J member 16
    Gene namesi
    Name:KCNJ16
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 17

    Organism-specific databases

    HGNCiHGNC:6262. KCNJ16.

    Subcellular locationi

    GO - Cellular componenti

    1. plasma membrane Source: Reactome
    2. voltage-gated potassium channel complex Source: UniProtKB

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA30047.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 418418Inward rectifier potassium channel 16PRO_0000154975Add
    BLAST

    Proteomic databases

    PaxDbiQ9NPI9.
    PRIDEiQ9NPI9.

    PTM databases

    PhosphoSiteiQ9NPI9.

    Expressioni

    Tissue specificityi

    Highly expressed in kidney, pancreas and thyroid gland.

    Gene expression databases

    ArrayExpressiQ9NPI9.
    BgeeiQ9NPI9.
    CleanExiHS_KCNJ16.
    GenevestigatoriQ9NPI9.

    Organism-specific databases

    HPAiHPA059563.

    Interactioni

    Subunit structurei

    Seems to form heterodimer with Kir4.1/KCNJ10 or Kir2.1/KCNJ2.

    Protein-protein interaction databases

    IntActiQ9NPI9. 2 interactions.
    STRINGi9606.ENSP00000283936.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9NPI9.
    SMRiQ9NPI9. Positions 33-344.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 7070CytoplasmicBy similarityAdd
    BLAST
    Topological domaini96 – 11722ExtracellularBy similarityAdd
    BLAST
    Topological domaini137 – 1459ExtracellularBy similarity
    Topological domaini168 – 418251CytoplasmicBy similarityAdd
    BLAST

    Intramembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Intramembranei118 – 12912Helical; Pore-forming; Name=H5By similarityAdd
    BLAST
    Intramembranei130 – 1367Pore-formingBy similarity

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei71 – 9525Helical; Name=M1By similarityAdd
    BLAST
    Transmembranei146 – 16722Helical; Name=M2By similarityAdd
    BLAST

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi131 – 1366Selectivity filterBy similarity

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG277052.
    HOGENOMiHOG000237325.
    HOVERGENiHBG006178.
    InParanoidiQ9NPI9.
    KOiK05009.
    OrthoDBiEOG7XPZ5K.
    PhylomeDBiQ9NPI9.
    TreeFamiTF313676.

    Family and domain databases

    Gene3Di2.60.40.1400. 1 hit.
    InterProiIPR014756. Ig_E-set.
    IPR016449. K_chnl_inward-rec_Kir.
    IPR008061. K_chnl_inward-rec_Kir5.
    IPR013518. K_chnl_inward-rec_Kir_cyto.
    [Graphical view]
    PANTHERiPTHR11767. PTHR11767. 1 hit.
    PTHR11767:SF24. PTHR11767:SF24. 1 hit.
    PfamiPF01007. IRK. 1 hit.
    [Graphical view]
    PIRSFiPIRSF005465. GIRK_kir. 1 hit.
    PRINTSiPR01678. KIR5CHANNEL.
    PR01320. KIRCHANNEL.
    SUPFAMiSSF81296. SSF81296. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q9NPI9-1 [UniParc]FASTAAdd to Basket

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    MSYYGSSYHI INADAKYPGY PPEHIIAEKR RARRRLLHKD GSCNVYFKHI    50
    FGEWGSYVVD IFTTLVDTKW RHMFVIFSLS YILSWLIFGS VFWLIAFHHG 100
    DLLNDPDITP CVDNVHSFTG AFLFSLETQT TIGYGYRCVT EECSVAVLMV 150
    ILQSILSCII NTFIIGAALA KMATARKRAQ TIRFSYFALI GMRDGKLCLM 200
    WRIGDFRPNH VVEGTVRAQL LRYTEDSEGR MTMAFKDLKL VNDQIILVTP 250
    VTIVHEIDHE SPLYALDRKA VAKDNFEILV TFIYTGDSTG TSHQSRSSYV 300
    PREILWGHRF NDVLEVKRKY YKVNCLQFEG SVEVYAPFCS AKQLDWKDQQ 350
    LHIEKAPPVR ESCTSDTKAR RRSFSAVAIV SSCENPEETT TSATHEYRET 400
    PYQKALLTLN RISVESQM 418
    Length:418
    Mass (Da):47,949
    Last modified:October 1, 2000 - v1
    Checksum:i1E241B4C15CBD264
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti11 – 111I → V.
    Corresponds to variant rs9302912 [ dbSNP | Ensembl ].
    VAR_024510

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF179353 mRNA. Translation: AAG09401.1.
    AF153814 Genomic DNA. Translation: AAF73244.1.
    AF153815 mRNA. Translation: AAF73238.1.
    AF153816 mRNA. Translation: AAF73239.1.
    AF153817 mRNA. Translation: AAF73240.1.
    CCDSiCCDS11687.1.
    RefSeqiNP_001257351.1. NM_001270422.1.
    NP_001278551.1. NM_001291622.1.
    NP_001278552.1. NM_001291623.1.
    NP_001278553.1. NM_001291624.1.
    NP_001278554.1. NM_001291625.1.
    NP_061128.2. NM_018658.2.
    NP_733937.2. NM_170741.2.
    NP_733938.2. NM_170742.2.
    XP_006721953.1. XM_006721890.1.
    UniGeneiHs.463985.

    Genome annotation databases

    EnsembliENST00000283936; ENSP00000283936; ENSG00000153822.
    ENST00000392670; ENSP00000376438; ENSG00000153822.
    ENST00000392671; ENSP00000376439; ENSG00000153822.
    ENST00000589377; ENSP00000465967; ENSG00000153822.
    GeneIDi3773.
    KEGGihsa:3773.
    UCSCiuc002jin.4. human.

    Polymorphism databases

    DMDMi13878562.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF179353 mRNA. Translation: AAG09401.1 .
    AF153814 Genomic DNA. Translation: AAF73244.1 .
    AF153815 mRNA. Translation: AAF73238.1 .
    AF153816 mRNA. Translation: AAF73239.1 .
    AF153817 mRNA. Translation: AAF73240.1 .
    CCDSi CCDS11687.1.
    RefSeqi NP_001257351.1. NM_001270422.1.
    NP_001278551.1. NM_001291622.1.
    NP_001278552.1. NM_001291623.1.
    NP_001278553.1. NM_001291624.1.
    NP_001278554.1. NM_001291625.1.
    NP_061128.2. NM_018658.2.
    NP_733937.2. NM_170741.2.
    NP_733938.2. NM_170742.2.
    XP_006721953.1. XM_006721890.1.
    UniGenei Hs.463985.

    3D structure databases

    ProteinModelPortali Q9NPI9.
    SMRi Q9NPI9. Positions 33-344.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q9NPI9. 2 interactions.
    STRINGi 9606.ENSP00000283936.

    Protein family/group databases

    TCDBi 1.A.2.1.11. inward rectifier k(+) channel (irk-c) family.

    PTM databases

    PhosphoSitei Q9NPI9.

    Polymorphism databases

    DMDMi 13878562.

    Proteomic databases

    PaxDbi Q9NPI9.
    PRIDEi Q9NPI9.

    Protocols and materials databases

    DNASUi 3773.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000283936 ; ENSP00000283936 ; ENSG00000153822 .
    ENST00000392670 ; ENSP00000376438 ; ENSG00000153822 .
    ENST00000392671 ; ENSP00000376439 ; ENSG00000153822 .
    ENST00000589377 ; ENSP00000465967 ; ENSG00000153822 .
    GeneIDi 3773.
    KEGGi hsa:3773.
    UCSCi uc002jin.4. human.

    Organism-specific databases

    CTDi 3773.
    GeneCardsi GC17P068071.
    HGNCi HGNC:6262. KCNJ16.
    HPAi HPA059563.
    MIMi 605722. gene.
    neXtProti NX_Q9NPI9.
    PharmGKBi PA30047.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG277052.
    HOGENOMi HOG000237325.
    HOVERGENi HBG006178.
    InParanoidi Q9NPI9.
    KOi K05009.
    OrthoDBi EOG7XPZ5K.
    PhylomeDBi Q9NPI9.
    TreeFami TF313676.

    Enzyme and pathway databases

    Reactomei REACT_25004. Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits.
    REACT_75815. Potassium transport channels.
    REACT_75831. Activation of G protein gated Potassium channels.

    Miscellaneous databases

    GeneWikii KCNJ16.
    GenomeRNAii 3773.
    NextBioi 14799.
    PROi Q9NPI9.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9NPI9.
    Bgeei Q9NPI9.
    CleanExi HS_KCNJ16.
    Genevestigatori Q9NPI9.

    Family and domain databases

    Gene3Di 2.60.40.1400. 1 hit.
    InterProi IPR014756. Ig_E-set.
    IPR016449. K_chnl_inward-rec_Kir.
    IPR008061. K_chnl_inward-rec_Kir5.
    IPR013518. K_chnl_inward-rec_Kir_cyto.
    [Graphical view ]
    PANTHERi PTHR11767. PTHR11767. 1 hit.
    PTHR11767:SF24. PTHR11767:SF24. 1 hit.
    Pfami PF01007. IRK. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF005465. GIRK_kir. 1 hit.
    PRINTSi PR01678. KIR5CHANNEL.
    PR01320. KIRCHANNEL.
    SUPFAMi SSF81296. SSF81296. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The human inward rectifier K(+) channel subunit kir5.1 (KCNJ16) maps to chromosome 17q25 and is expressed in kidney and pancreas."
      Liu Y., McKenna E., Figueroa D.J., Blevins R., Austin C.P., Bennett P.B., Swanson R.
      Cytogenet. Cell Genet. 90:60-63(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
      Tissue: Kidney and Parathyroid.

    Entry informationi

    Entry nameiKCJ16_HUMAN
    AccessioniPrimary (citable) accession number: Q9NPI9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 27, 2001
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 121 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 17
      Human chromosome 17: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3