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Protein

Inward rectifier potassium channel 16

Gene

KCNJ16

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. KCNJ16 may be involved in the regulation of fluid and pH balance.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei161 – 1611Role in the control of polyamine-mediated channel gating and in the blocking by intracellular magnesiumBy similarity

GO - Molecular functioni

  1. inward rectifier potassium channel activity Source: UniProtKB

GO - Biological processi

  1. potassium ion import Source: GO_Central
  2. potassium ion transport Source: UniProtKB
  3. regulation of ion transmembrane transport Source: GO_Central
  4. synaptic transmission Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Voltage-gated channel

Keywords - Biological processi

Ion transport, Potassium transport, Transport

Keywords - Ligandi

Potassium

Enzyme and pathway databases

ReactomeiREACT_25004. Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits.
REACT_75815. Potassium transport channels.
REACT_75831. Activation of G protein gated Potassium channels.

Protein family/group databases

TCDBi1.A.2.1.11. inward rectifier k(+) channel (irk-c) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Inward rectifier potassium channel 16
Alternative name(s):
Inward rectifier K(+) channel Kir5.1
Potassium channel, inwardly rectifying subfamily J member 16
Gene namesi
Name:KCNJ16
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:6262. KCNJ16.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 7070CytoplasmicBy similarityAdd
BLAST
Transmembranei71 – 9525Helical; Name=M1By similarityAdd
BLAST
Topological domaini96 – 11722ExtracellularBy similarityAdd
BLAST
Intramembranei118 – 12912Helical; Pore-forming; Name=H5By similarityAdd
BLAST
Intramembranei130 – 1367Pore-formingBy similarity
Topological domaini137 – 1459ExtracellularBy similarity
Transmembranei146 – 16722Helical; Name=M2By similarityAdd
BLAST
Topological domaini168 – 418251CytoplasmicBy similarityAdd
BLAST

GO - Cellular componenti

  1. integral component of plasma membrane Source: GO_Central
  2. plasma membrane Source: Reactome
  3. voltage-gated potassium channel complex Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA30047.

Polymorphism and mutation databases

BioMutaiKCNJ16.
DMDMi13878562.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 418418Inward rectifier potassium channel 16PRO_0000154975Add
BLAST

Proteomic databases

PaxDbiQ9NPI9.
PRIDEiQ9NPI9.

PTM databases

PhosphoSiteiQ9NPI9.

Expressioni

Tissue specificityi

Highly expressed in kidney, pancreas and thyroid gland.

Gene expression databases

BgeeiQ9NPI9.
CleanExiHS_KCNJ16.
ExpressionAtlasiQ9NPI9. baseline and differential.
GenevestigatoriQ9NPI9.

Organism-specific databases

HPAiHPA059563.

Interactioni

Subunit structurei

Seems to form heterodimer with Kir4.1/KCNJ10 or Kir2.1/KCNJ2.

Protein-protein interaction databases

IntActiQ9NPI9. 2 interactions.
STRINGi9606.ENSP00000283936.

Structurei

3D structure databases

ProteinModelPortaliQ9NPI9.
SMRiQ9NPI9. Positions 33-344.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi131 – 1366Selectivity filterBy similarity

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG277052.
GeneTreeiENSGT00760000118842.
HOGENOMiHOG000237325.
HOVERGENiHBG006178.
InParanoidiQ9NPI9.
KOiK05009.
OrthoDBiEOG7XPZ5K.
PhylomeDBiQ9NPI9.
TreeFamiTF313676.

Family and domain databases

Gene3Di2.60.40.1400. 1 hit.
InterProiIPR014756. Ig_E-set.
IPR016449. K_chnl_inward-rec_Kir.
IPR008061. K_chnl_inward-rec_Kir5.
IPR013518. K_chnl_inward-rec_Kir_cyto.
[Graphical view]
PANTHERiPTHR11767. PTHR11767. 1 hit.
PTHR11767:SF24. PTHR11767:SF24. 1 hit.
PfamiPF01007. IRK. 1 hit.
[Graphical view]
PIRSFiPIRSF005465. GIRK_kir. 1 hit.
PRINTSiPR01678. KIR5CHANNEL.
PR01320. KIRCHANNEL.
SUPFAMiSSF81296. SSF81296. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9NPI9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSYYGSSYHI INADAKYPGY PPEHIIAEKR RARRRLLHKD GSCNVYFKHI
60 70 80 90 100
FGEWGSYVVD IFTTLVDTKW RHMFVIFSLS YILSWLIFGS VFWLIAFHHG
110 120 130 140 150
DLLNDPDITP CVDNVHSFTG AFLFSLETQT TIGYGYRCVT EECSVAVLMV
160 170 180 190 200
ILQSILSCII NTFIIGAALA KMATARKRAQ TIRFSYFALI GMRDGKLCLM
210 220 230 240 250
WRIGDFRPNH VVEGTVRAQL LRYTEDSEGR MTMAFKDLKL VNDQIILVTP
260 270 280 290 300
VTIVHEIDHE SPLYALDRKA VAKDNFEILV TFIYTGDSTG TSHQSRSSYV
310 320 330 340 350
PREILWGHRF NDVLEVKRKY YKVNCLQFEG SVEVYAPFCS AKQLDWKDQQ
360 370 380 390 400
LHIEKAPPVR ESCTSDTKAR RRSFSAVAIV SSCENPEETT TSATHEYRET
410
PYQKALLTLN RISVESQM
Length:418
Mass (Da):47,949
Last modified:October 1, 2000 - v1
Checksum:i1E241B4C15CBD264
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti11 – 111I → V.
Corresponds to variant rs9302912 [ dbSNP | Ensembl ].
VAR_024510

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF179353 mRNA. Translation: AAG09401.1.
AF153814 Genomic DNA. Translation: AAF73244.1.
AF153815 mRNA. Translation: AAF73238.1.
AF153816 mRNA. Translation: AAF73239.1.
AF153817 mRNA. Translation: AAF73240.1.
CCDSiCCDS11687.1.
RefSeqiNP_001257351.1. NM_001270422.1.
NP_001278551.1. NM_001291622.1.
NP_001278552.1. NM_001291623.1.
NP_001278553.1. NM_001291624.1.
NP_001278554.1. NM_001291625.1.
NP_061128.2. NM_018658.2.
NP_733937.2. NM_170741.2.
NP_733938.2. NM_170742.2.
UniGeneiHs.463985.

Genome annotation databases

EnsembliENST00000283936; ENSP00000283936; ENSG00000153822.
ENST00000392670; ENSP00000376438; ENSG00000153822.
ENST00000392671; ENSP00000376439; ENSG00000153822.
ENST00000589377; ENSP00000465967; ENSG00000153822.
ENST00000615244; ENSP00000479817; ENSG00000153822.
GeneIDi3773.
KEGGihsa:3773.
UCSCiuc002jin.4. human.

Polymorphism and mutation databases

BioMutaiKCNJ16.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF179353 mRNA. Translation: AAG09401.1.
AF153814 Genomic DNA. Translation: AAF73244.1.
AF153815 mRNA. Translation: AAF73238.1.
AF153816 mRNA. Translation: AAF73239.1.
AF153817 mRNA. Translation: AAF73240.1.
CCDSiCCDS11687.1.
RefSeqiNP_001257351.1. NM_001270422.1.
NP_001278551.1. NM_001291622.1.
NP_001278552.1. NM_001291623.1.
NP_001278553.1. NM_001291624.1.
NP_001278554.1. NM_001291625.1.
NP_061128.2. NM_018658.2.
NP_733937.2. NM_170741.2.
NP_733938.2. NM_170742.2.
UniGeneiHs.463985.

3D structure databases

ProteinModelPortaliQ9NPI9.
SMRiQ9NPI9. Positions 33-344.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9NPI9. 2 interactions.
STRINGi9606.ENSP00000283936.

Protein family/group databases

TCDBi1.A.2.1.11. inward rectifier k(+) channel (irk-c) family.

PTM databases

PhosphoSiteiQ9NPI9.

Polymorphism and mutation databases

BioMutaiKCNJ16.
DMDMi13878562.

Proteomic databases

PaxDbiQ9NPI9.
PRIDEiQ9NPI9.

Protocols and materials databases

DNASUi3773.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000283936; ENSP00000283936; ENSG00000153822.
ENST00000392670; ENSP00000376438; ENSG00000153822.
ENST00000392671; ENSP00000376439; ENSG00000153822.
ENST00000589377; ENSP00000465967; ENSG00000153822.
ENST00000615244; ENSP00000479817; ENSG00000153822.
GeneIDi3773.
KEGGihsa:3773.
UCSCiuc002jin.4. human.

Organism-specific databases

CTDi3773.
GeneCardsiGC17P068071.
HGNCiHGNC:6262. KCNJ16.
HPAiHPA059563.
MIMi605722. gene.
neXtProtiNX_Q9NPI9.
PharmGKBiPA30047.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG277052.
GeneTreeiENSGT00760000118842.
HOGENOMiHOG000237325.
HOVERGENiHBG006178.
InParanoidiQ9NPI9.
KOiK05009.
OrthoDBiEOG7XPZ5K.
PhylomeDBiQ9NPI9.
TreeFamiTF313676.

Enzyme and pathway databases

ReactomeiREACT_25004. Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits.
REACT_75815. Potassium transport channels.
REACT_75831. Activation of G protein gated Potassium channels.

Miscellaneous databases

GeneWikiiKCNJ16.
GenomeRNAii3773.
NextBioi14799.
PROiQ9NPI9.
SOURCEiSearch...

Gene expression databases

BgeeiQ9NPI9.
CleanExiHS_KCNJ16.
ExpressionAtlasiQ9NPI9. baseline and differential.
GenevestigatoriQ9NPI9.

Family and domain databases

Gene3Di2.60.40.1400. 1 hit.
InterProiIPR014756. Ig_E-set.
IPR016449. K_chnl_inward-rec_Kir.
IPR008061. K_chnl_inward-rec_Kir5.
IPR013518. K_chnl_inward-rec_Kir_cyto.
[Graphical view]
PANTHERiPTHR11767. PTHR11767. 1 hit.
PTHR11767:SF24. PTHR11767:SF24. 1 hit.
PfamiPF01007. IRK. 1 hit.
[Graphical view]
PIRSFiPIRSF005465. GIRK_kir. 1 hit.
PRINTSiPR01678. KIR5CHANNEL.
PR01320. KIRCHANNEL.
SUPFAMiSSF81296. SSF81296. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "The human inward rectifier K(+) channel subunit kir5.1 (KCNJ16) maps to chromosome 17q25 and is expressed in kidney and pancreas."
    Liu Y., McKenna E., Figueroa D.J., Blevins R., Austin C.P., Bennett P.B., Swanson R.
    Cytogenet. Cell Genet. 90:60-63(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
    Tissue: Kidney and Parathyroid.

Entry informationi

Entry nameiKCJ16_HUMAN
AccessioniPrimary (citable) accession number: Q9NPI9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: October 1, 2000
Last modified: April 29, 2015
This is version 125 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.