Q9NPI9 (IRK16_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Inward rectifier potassium channel 16

Alternative name(s):
Inward rectifier K(+) channel Kir5.1
Potassium channel, inwardly rectifying subfamily J member 16

Gene names

Name:

KCNJ16

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	418 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. KCNJ16 may be involved in the regulation of fluid and pH balance.
Subunit structure	Seems to form heterodimer with Kir4.1/KCNJ10 or Kir2.1/KCNJ2.
Subcellular location	Membrane; Multi-pass membrane protein.
Tissue specificity	Highly expressed in kidney, pancreas and thyroid gland.
Sequence similarities	Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ16 subfamily. [View classification]

Ontologies

Keywords
Biological process	Ion transport Potassium transport Transport
Cellular component	Membrane
Coding sequence diversity	Polymorphism
Domain	Transmembrane Transmembrane helix
Ligand	Potassium
Molecular function	Ion channel Voltage-gated channel
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	synaptic transmission Traceable author statement. Source: Reactome
Cellular_component	voltage-gated potassium channel complex Non-traceable author statement Ref.1. Source: UniProtKB
Molecular_function	inward rectifier potassium channel activity Non-traceable author statement Ref.1. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 418	418	Inward rectifier potassium channel 16		PRO_0000154975
Regions
	Topological domain	1 – 70	70	Cytoplasmic By similarity
	Transmembrane	71 – 95	25	Helical; Name=M1; By similarity
	Topological domain	96 – 117	22	Extracellular By similarity
	Intramembrane	118 – 129	12	Helical; Pore-forming; Name=H5; By similarity
	Intramembrane	130 – 136	7	Pore-forming; By similarity
	Topological domain	137 – 145	9	Extracellular By similarity
	Transmembrane	146 – 167	22	Helical; Name=M2; By similarity
	Topological domain	168 – 418	251	Cytoplasmic By similarity
	Motif	131 – 136	6	Selectivity filter By similarity
Sites
	Site	161	1	Role in the control of polyamine-mediated channel gating and in the blocking by intracellular magnesium By similarity
Natural variations
	Natural variant	11	1	I → V. Corresponds to variant rs9302912 [ dbSNP | Ensembl ].		VAR_024510

Sequences

	Sequence		Length	Mass (Da)
	Q9NPI9 [UniParc]. Last modified October 1, 2000. Version 1. Checksum: 1E241B4C15CBD264	FASTA	418	47,949
	10 20 30 40 50 60 MSYYGSSYHI INADAKYPGY PPEHIIAEKR RARRRLLHKD GSCNVYFKHI FGEWGSYVVD 70 80 90 100 110 120 IFTTLVDTKW RHMFVIFSLS YILSWLIFGS VFWLIAFHHG DLLNDPDITP CVDNVHSFTG 130 140 150 160 170 180 AFLFSLETQT TIGYGYRCVT EECSVAVLMV ILQSILSCII NTFIIGAALA KMATARKRAQ 190 200 210 220 230 240 TIRFSYFALI GMRDGKLCLM WRIGDFRPNH VVEGTVRAQL LRYTEDSEGR MTMAFKDLKL 250 260 270 280 290 300 VNDQIILVTP VTIVHEIDHE SPLYALDRKA VAKDNFEILV TFIYTGDSTG TSHQSRSSYV 310 320 330 340 350 360 PREILWGHRF NDVLEVKRKY YKVNCLQFEG SVEVYAPFCS AKQLDWKDQQ LHIEKAPPVR 370 380 390 400 410 ESCTSDTKAR RRSFSAVAIV SSCENPEETT TSATHEYRET PYQKALLTLN RISVESQM

References

[1]	"The human inward rectifier K(+) channel subunit kir5.1 (KCNJ16) maps to chromosome 17q25 and is expressed in kidney and pancreas." Liu Y., McKenna E., Figueroa D.J., Blevins R., Austin C.P., Bennett P.B., Swanson R. Cytogenet. Cell Genet. 90:60-63(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Genetic and functional linkage of Kir5.1 and Kir2.1 channel subunits." Derst C., Karschin C., Wischmeyer E., Hirsch J.R., Preisig-Muller R., Rajan S., Engel H., Grzeschik K., Daut J., Karschin A. FEBS Lett. 491:305-311(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA]. Tissue: Kidney and Parathyroid.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF179353 mRNA. Translation: AAG09401.1. AF153814 Genomic DNA. Translation: AAF73244.1. AF153815 mRNA. Translation: AAF73238.1. AF153816 mRNA. Translation: AAF73239.1. AF153817 mRNA. Translation: AAF73240.1.
IPI	IPI00014915.
RefSeq	NP_001257351.1. NM_001270422.1. NP_061128.1. NM_018658.2. NP_733937.1. NM_170741.2.
UniGene	Hs.463985.
3D structure databases
ProteinModelPortal	Q9NPI9.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9NPI9. 1 interaction.
STRING	9606.ENSP00000283936.
PTM databases
PhosphoSite	Q9NPI9.
Polymorphism databases
DMDM	13878562.
Proteomic databases
PaxDb	Q9NPI9.
PRIDE	Q9NPI9.
Protocols and materials databases
DNASU	3773.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000283936; ENSP00000283936; ENSG00000153822. ENST00000392670; ENSP00000376438; ENSG00000153822. ENST00000392671; ENSP00000376439; ENSG00000153822. ENST00000589377; ENSP00000465967; ENSG00000153822.
GeneID	3773.
KEGG	hsa:3773.
UCSC	uc002jin.3. human.
Organism-specific databases
CTD	3773.
GeneCards	GC17P068071.
HGNC	HGNC:6262. KCNJ16.
MIM	605722. gene.
neXtProt	NX_Q9NPI9.
PharmGKB	PA30047.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG277052.
HOGENOM	HOG000237325.
HOVERGEN	HBG006178.
InParanoid	Q9NPI9.
KO	K05009.
OMA	SIFWLIA.
OrthoDB	EOG4GB763.
PhylomeDB	Q9NPI9.
Enzyme and pathway databases
Reactome	REACT_13685. Neuronal System.
Gene expression databases
Bgee	Q9NPI9.
CleanEx	HS_KCNJ16.
Genevestigator	Q9NPI9.
GermOnline	ENSG00000153822. Homo sapiens.
Family and domain databases
Gene3D	2.60.40.1400. 1 hit.
InterPro	IPR014756. Ig_E-set. IPR016449. K_chnl_inward-rec_Kir. IPR008061. K_chnl_inward-rec_Kir5. IPR013518. K_chnl_inward-rec_Kir_cyto. [Graphical view]
PANTHER	PTHR11767. PTHR11767. 1 hit. PTHR11767:SF24. PTHR11767:SF24. 1 hit.
Pfam	PF01007. IRK. 1 hit. [Graphical view]
PIRSF	PIRSF005465. GIRK_kir. 1 hit.
PRINTS	PR01678. KIR5CHANNEL. PR01320. KIRCHANNEL.
SUPFAM	SSF81296. Ig_E-set. 1 hit.
ProtoNet	Search...
Other
GenomeRNAi	3773.
NextBio	14799.
SOURCE	Search...

Entry information

Entry name

IRK16_HUMAN

Accession

Primary (citable) accession number: Q9NPI9

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 27, 2001
Last sequence update:	October 1, 2000
Last modified:	May 1, 2013
This is version 108 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.