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Protein

mRNA-decapping enzyme 1A

Gene

DCP1A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP. Contributes to the transactivation of target genes after stimulation by TGFB1.2 Publications

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Nonsense-mediated mRNA decay

Enzyme and pathway databases

BioCyciZFISH:ENSG00000162290-MONOMER.
ReactomeiR-HSA-430039. mRNA decay by 5' to 3' exoribonuclease.
R-HSA-450385. Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA.
R-HSA-450513. Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA.
R-HSA-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Protein family/group databases

TCDBi3.A.18.1.1. the nuclear mrna exporter (mrna-e) family.

Names & Taxonomyi

Protein namesi
Recommended name:
mRNA-decapping enzyme 1A (EC:3.-.-.-)
Alternative name(s):
Smad4-interacting transcriptional co-activator
Transcription factor SMIF
Gene namesi
Name:DCP1A
Synonyms:SMIF
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:18714. DCP1A.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: AgBase
  • cytoplasmic mRNA processing body Source: UniProtKB
  • cytosol Source: Reactome
  • intracellular membrane-bounded organelle Source: HPA
  • membrane Source: UniProtKB
  • nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi20D → A: Lowers decapping activity. 1 Publication1
Mutagenesisi59R → A: Lowers decapping activity. 1 Publication1

Organism-specific databases

DisGeNETi55802.
PharmGKBiPA134931379.

Polymorphism and mutation databases

BioMutaiDCP1A.
DMDMi296434475.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001896321 – 582mRNA-decapping enzyme 1AAdd BLAST582

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei62PhosphoserineCombined sources1
Modified residuei142PhosphoserineCombined sources1
Modified residuei179PhosphoserineBy similarity1
Modified residuei180PhosphoserineCombined sources1
Modified residuei315PhosphoserineCombined sources1
Modified residuei319PhosphoserineCombined sources1
Modified residuei334PhosphoserineCombined sources1
Modified residuei348PhosphothreonineCombined sources1
Modified residuei353PhosphoserineCombined sources1
Modified residuei376Asymmetric dimethylarginineCombined sources1
Modified residuei401PhosphothreonineCombined sources1
Modified residuei422PhosphoserineCombined sources1
Modified residuei522PhosphoserineCombined sources1
Modified residuei523PhosphoserineCombined sources1
Modified residuei525PhosphoserineCombined sources1
Modified residuei528PhosphothreonineBy similarity1
Modified residuei531PhosphothreonineCombined sources1

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

EPDiQ9NPI6.
MaxQBiQ9NPI6.
PeptideAtlasiQ9NPI6.
PRIDEiQ9NPI6.

PTM databases

iPTMnetiQ9NPI6.
PhosphoSitePlusiQ9NPI6.

Expressioni

Tissue specificityi

Detected in heart, brain, placenta, lung, skeletal muscle, liver, kidney and pancreas.1 Publication

Gene expression databases

BgeeiENSG00000272886.
CleanExiHS_DCP1A.
ExpressionAtlasiQ9NPI6. baseline and differential.
GenevisibleiQ9NPI6. HS.

Organism-specific databases

HPAiHPA013202.

Interactioni

Subunit structurei

Forms a complex with EDC3, DCP2, DDX6 and EDC4/HEDLS, within this complex directly interacts with EDC3 (PubMed:16364915). Part of a cytoplasmic complex containing proteins involved in mRNA decay, including XRN1 and LSM1 (PubMed:12515382). Interacts with DCP1B (PubMed:12417715). Interacts with DCP2 (PubMed:12417715). Interacts with DDX17 in an RNA-independent manner (PubMed:21876179). Interacts with PNRC2 (PubMed:19150429). Interacts with SMAD4 (PubMed:11836524). Interacts with UPF1 (PubMed:12417715). Interacts with ZC3HAV1 (PubMed:21876179). Interacts with ZFP36L1 (PubMed:15687258).7 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
itself4EBI-374238,EBI-374238
BAG4O954294EBI-374238,EBI-2949658
DCP2Q8IU608EBI-374238,EBI-521577
DDX6P261966EBI-374238,EBI-351257
EDC3Q96F8611EBI-374238,EBI-997311
FHL2Q141923EBI-374238,EBI-701903
PNRC2Q9NPJ48EBI-374238,EBI-726549
RITA1Q96K303EBI-374238,EBI-2836148
SMAD4Q134854EBI-374238,EBI-347263
UPF1Q9290013EBI-374238,EBI-373471
ZFP36P266512EBI-374238,EBI-374248

Protein-protein interaction databases

BioGridi120914. 44 interactors.
DIPiDIP-31292N.
IntActiQ9NPI6. 35 interactors.
MINTiMINT-5005647.

Structurei

Secondary structure

1582
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi1 – 19Combined sources19
Beta strandi23 – 39Combined sources17
Turni40 – 43Combined sources4
Beta strandi44 – 63Combined sources20
Beta strandi65 – 71Combined sources7
Beta strandi78 – 81Combined sources4
Beta strandi87 – 91Combined sources5
Beta strandi94 – 98Combined sources5
Beta strandi104 – 111Combined sources8
Helixi112 – 126Combined sources15
Helixi539 – 557Combined sources19
Helixi559 – 571Combined sources13

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2WX3X-ray2.31A/B/C539-582[»]
4B6HX-ray2.60A/B1-130[»]
ProteinModelPortaliQ9NPI6.
SMRiQ9NPI6.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9NPI6.

Family & Domainsi

Sequence similaritiesi

Belongs to the DCP1 family.Curated

Phylogenomic databases

HOVERGENiHBG051320.
InParanoidiQ9NPI6.
KOiK12610.
OrthoDBiEOG091G0JB7.
PhylomeDBiQ9NPI6.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
InterProiIPR010334. Dcp1.
IPR031953. mRNA_decap_C.
IPR011993. PH_dom-like.
[Graphical view]
PANTHERiPTHR16290. PTHR16290. 3 hits.
PfamiPF06058. DCP1. 1 hit.
PF16741. mRNA_decap_C. 1 hit.
[Graphical view]
SUPFAMiSSF50729. SSF50729. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9NPI6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEALSRAGQE MSLAALKQHD PYITSIADLT GQVALYTFCP KANQWEKTDI
60 70 80 90 100
EGTLFVYRRS ASPYHGFTIV NRLNMHNLVE PVNKDLEFQL HEPFLLYRNA
110 120 130 140 150
SLSIYSIWFY DKNDCHRIAK LMADVVEEET RRSQQAARDK QSPSQANGCS
160 170 180 190 200
DHRPIDILEM LSRAKDEYER NQMGDSNISS PGLQPSTQLS NLGSTETLEE
210 220 230 240 250
MPSGSQDKSA PSGHKHLTVE ELFGTSLPKE QPAVVGLDSE EMERLPGDAS
260 270 280 290 300
QKEPNSFLPF PFEQLGGAPQ SETLGVPSAA HHSVQPEITT PVLITPASIT
310 320 330 340 350
QSNEKHAPTY TIPLSPVLSP TLPAEAPTAQ VPPSLPRNST MMQAVKTTPR
360 370 380 390 400
QRSPLLNQPV PELSHASLIA NQSPFRAPLN VTNTAGTSLP SVDLLQKLRL
410 420 430 440 450
TPQHDQIQTQ PLGKGAMVAS FSPAAGQLAT PESFIEPPSK TAAARVAASA
460 470 480 490 500
SLSNMVLAPL QSMQQNQDPE VFVQPKVLSS AIQVAGAPLV TATTTAVSSV
510 520 530 540 550
LLAPSVFQQT VTRSSDLERK ASSPSPLTIG TPESQRKPSI ILSKSQLQDT
560 570 580
LIHLIKNDSS FLSTLHEVYL QVLTKNKDNH NL
Length:582
Mass (Da):63,309
Last modified:May 18, 2010 - v2
Checksum:iD218180ABA7FD768
GO
Isoform 2 (identifier: Q9NPI6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     171-208: Missing.

Note: No experimental confirmation available.
Show »
Length:544
Mass (Da):59,361
Checksum:i926A3D82B77BB43F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti483Q → P in AAN62763 (PubMed:12417715).Curated1
Sequence conflicti483Q → P in CAB77023 (PubMed:11836524).Curated1
Sequence conflicti483Q → P in BAA92008 (PubMed:14702039).Curated1
Sequence conflicti483Q → P in BAG58201 (PubMed:14702039).Curated1
Sequence conflicti483Q → P in AAH07439 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_057206171 – 208Missing in isoform 2. 1 PublicationAdd BLAST38

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY146651 mRNA. Translation: AAN62763.1.
AJ275986 mRNA. Translation: CAB77023.1.
AK001969 mRNA. Translation: BAA92008.1.
AK295205 mRNA. Translation: BAG58201.1.
AC097015 Genomic DNA. No translation available.
AC112218 Genomic DNA. No translation available.
BC007439 mRNA. Translation: AAH07439.1.
CCDSiCCDS46847.2. [Q9NPI6-1]
CCDS74946.1. [Q9NPI6-2]
RefSeqiNP_001277133.1. NM_001290204.1.
NP_001277134.1. NM_001290205.1.
NP_001277135.1. NM_001290206.1.
NP_001277136.1. NM_001290207.1.
NP_060873.4. NM_018403.6.
UniGeneiHs.476353.

Genome annotation databases

EnsembliENST00000294241; ENSP00000476046; ENSG00000272886.
ENST00000610213; ENSP00000476386; ENSG00000272886.
GeneIDi55802.
KEGGihsa:55802.
UCSCiuc021wzk.3. human. [Q9NPI6-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY146651 mRNA. Translation: AAN62763.1.
AJ275986 mRNA. Translation: CAB77023.1.
AK001969 mRNA. Translation: BAA92008.1.
AK295205 mRNA. Translation: BAG58201.1.
AC097015 Genomic DNA. No translation available.
AC112218 Genomic DNA. No translation available.
BC007439 mRNA. Translation: AAH07439.1.
CCDSiCCDS46847.2. [Q9NPI6-1]
CCDS74946.1. [Q9NPI6-2]
RefSeqiNP_001277133.1. NM_001290204.1.
NP_001277134.1. NM_001290205.1.
NP_001277135.1. NM_001290206.1.
NP_001277136.1. NM_001290207.1.
NP_060873.4. NM_018403.6.
UniGeneiHs.476353.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2WX3X-ray2.31A/B/C539-582[»]
4B6HX-ray2.60A/B1-130[»]
ProteinModelPortaliQ9NPI6.
SMRiQ9NPI6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120914. 44 interactors.
DIPiDIP-31292N.
IntActiQ9NPI6. 35 interactors.
MINTiMINT-5005647.

Protein family/group databases

TCDBi3.A.18.1.1. the nuclear mrna exporter (mrna-e) family.

PTM databases

iPTMnetiQ9NPI6.
PhosphoSitePlusiQ9NPI6.

Polymorphism and mutation databases

BioMutaiDCP1A.
DMDMi296434475.

Proteomic databases

EPDiQ9NPI6.
MaxQBiQ9NPI6.
PeptideAtlasiQ9NPI6.
PRIDEiQ9NPI6.

Protocols and materials databases

DNASUi55802.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000294241; ENSP00000476046; ENSG00000272886.
ENST00000610213; ENSP00000476386; ENSG00000272886.
GeneIDi55802.
KEGGihsa:55802.
UCSCiuc021wzk.3. human. [Q9NPI6-1]

Organism-specific databases

CTDi55802.
DisGeNETi55802.
GeneCardsiDCP1A.
HGNCiHGNC:18714. DCP1A.
HPAiHPA013202.
MIMi607010. gene.
neXtProtiNX_Q9NPI6.
PharmGKBiPA134931379.
GenAtlasiSearch...

Phylogenomic databases

HOVERGENiHBG051320.
InParanoidiQ9NPI6.
KOiK12610.
OrthoDBiEOG091G0JB7.
PhylomeDBiQ9NPI6.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000162290-MONOMER.
ReactomeiR-HSA-430039. mRNA decay by 5' to 3' exoribonuclease.
R-HSA-450385. Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA.
R-HSA-450513. Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA.
R-HSA-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Miscellaneous databases

ChiTaRSiDCP1A. human.
EvolutionaryTraceiQ9NPI6.
GeneWikiiDCP1A.
GenomeRNAii55802.
PROiQ9NPI6.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000272886.
CleanExiHS_DCP1A.
ExpressionAtlasiQ9NPI6. baseline and differential.
GenevisibleiQ9NPI6. HS.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
InterProiIPR010334. Dcp1.
IPR031953. mRNA_decap_C.
IPR011993. PH_dom-like.
[Graphical view]
PANTHERiPTHR16290. PTHR16290. 3 hits.
PfamiPF06058. DCP1. 1 hit.
PF16741. mRNA_decap_C. 1 hit.
[Graphical view]
SUPFAMiSSF50729. SSF50729. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiDCP1A_HUMAN
AccessioniPrimary (citable) accession number: Q9NPI6
Secondary accession number(s): B4DHN9, U3KQM8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: May 18, 2010
Last modified: November 30, 2016
This is version 136 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.