Q9NPH9 (IL26_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Interleukin-26
Short name=IL-26

Alternative name(s):
Protein AK155

Gene names

Name:	IL26
Synonyms:	AK155

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	171 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May play a role in local mechanisms of mucosal immunity and seems to have a proinflammatory function. May play a role in inflammatory bowel disease. Activates STAT1 and STAT3, MAPK1/3 (ERK1/2), JUN and AKT. Induces expression of SOCS3, TNF-alpha and IL-8, secretion of IL-8 and IL-10 and surface expression of ICAM1. Decreases proliferation of intestinal epithelial cells. Is inhibited by heparin. Ref.4 Ref.5 Ref.6
Subunit structure	Homodimer.
Subcellular location	Secreted Ref.6.
Tissue specificity	Expressed in HVS transformed T-cells but not other T-cell lines or primary stimulated T-cells. Expressed in colonic T-cells including Th17 inflammatory T-cells; the expression is significantly increased in serum of patients with Crohn's disease (at protein level). Ref.6
Induction	By Herpesvirus saimiri infection.
Sequence similarities	Belongs to the IL-10 family.

Ontologies

Keywords
Cellular component	Secreted
Domain	Signal
Molecular function	Cytokine
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cell-cell signaling Traceable author statement Ref.1. Source: ProtInc negative regulation of epithelial cell proliferation Inferred from direct assay Ref.6. Source: UniProtKB positive regulation of ERK1 and ERK2 cascade Inferred from direct assay Ref.6. Source: UniProtKB positive regulation of JAK-STAT cascade Inferred from direct assay Ref.6. Source: UniProtKB positive regulation of cytokine secretion Inferred from direct assay Ref.6. Source: UniProtKB positive regulation of protein kinase B signaling cascade Inferred from direct assay Ref.6. Source: UniProtKB positive regulation of stress-activated MAPK cascade Inferred from direct assay Ref.6. Source: UniProtKB positive regulation of transcription from RNA polymerase II promoter Inferred from direct assay Ref.6. Source: UniProtKB
Cellular_component	cytosol Inferred from direct assay Ref.6. Source: UniProtKB extracellular space Inferred from direct assay Ref.6. Source: UniProtKB
Molecular_function	cytokine activity Inferred from direct assay Ref.6. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 21	21	Potential
	Chain	22 – 171	150	Interleukin-26		PRO_0000015387

Sequences

	Sequence		Length	Mass (Da)
	Q9NPH9 [UniParc]. Last modified October 1, 2000. Version 1. Checksum: 31F6261E42B6ACC0	FASTA	171	19,843
	10 20 30 40 50 60 MLVNFILRCG LLLVTLSLAI AKHKQSSFTK SCYPRGTLSQ AVDALYIKAA WLKATIPEDR 70 80 90 100 110 120 IKNIRLLKKK TKKQFMKNCQ FQEQLLSFFM EDVFGQLQLQ GCKKIRFVED FHSLRQKLSH 130 140 150 160 170 CISCASSARE MKSITRMKRI FYRIGNKGIY KAISELDILL SWIKKLLESS Q

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Induction of a novel cellular homolog of interleukin-10, AK155, by transformation of T lymphocytes with herpesvirus saimiri." Knappe A., Hor S., Wittmann S., Fickenscher H. J. Virol. 74:3881-3887(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
[2]	SeattleSNPs variation discovery resource Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]	"The T-cell lymphokine interleukin-26 targets epithelial cells through the interleukin-20 receptor 1 and interleukin-10 receptor 2 chains." Hor S., Pirzer H., Dumoutier L., Bauer F., Wittmann S., Sticht H., Renauld J.C., de Waal Malefyt R., Fickenscher H. J. Biol. Chem. 279:33343-33351(2004) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION.
[5]	"IL-26 signals through a novel receptor complex composed of IL-20 receptor 1 and IL-10 receptor 2." Sheikh F., Baurin V.V., Lewis-Antes A., Shah N.K., Smirnov S.V., Anantha S., Dickensheets H., Dumoutier L., Renauld J.-C., Zdanov A., Donnelly R.P., Kotenko S.V. J. Immunol. 172:2006-2010(2004) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, RECEPTOR BINDING.
[6]	"The role of the novel Th17 cytokine IL-26 in intestinal inflammation." Dambacher J., Beigel F., Zitzmann K., De Toni E.N., Goke B., Diepolder H.M., Auernhammer C.J., Brand S. Gut 58:1207-1217(2009) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, TISSUE SPECIFICITY, SUBCELLULAR LOCATION.
+	Additional computationally mapped references.

Web resources

Wikipedia

Interleukin-26 entry

SeattleSNPs

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ251550, AJ251551 Genomic DNA. Translation: CAB77049.1. AJ251549 mRNA. Translation: CAB76942.1. AY509906 Genomic DNA. Translation: AAR87776.1. BC066270 mRNA. Translation: AAH66270.1. BC066271 mRNA. Translation: AAH66271.1.
IPI	IPI00020088.
RefSeq	NP_060872.1. NM_018402.1.
UniGene	Hs.272350.
3D structure databases
ProteinModelPortal	Q9NPH9.
SMR	Q9NPH9. Positions 32-168.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000229134.
PTM databases
PhosphoSite	Q9NPH9.
Polymorphism databases
DMDM	17366984.
Proteomic databases
PaxDb	Q9NPH9.
PRIDE	Q9NPH9.
Protocols and materials databases
DNASU	55801.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000229134; ENSP00000229134; ENSG00000111536.
GeneID	55801.
KEGG	hsa:55801.
UCSC	uc001stx.1. human.
Organism-specific databases
CTD	55801.
GeneCards	GC12M068595.
HGNC	HGNC:17119. IL26.
MIM	605679. gene.
neXtProt	NX_Q9NPH9.
PharmGKB	PA29826.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG86390.
HOGENOM	HOG000113042.
InParanoid	Q9NPH9.
KO	K05446.
OMA	WIKQFLE.
OrthoDB	EOG4K3KXH.
PhylomeDB	Q9NPH9.
Gene expression databases
Bgee	Q9NPH9.
CleanEx	HS_IL26.
Genevestigator	Q9NPH9.
GermOnline	ENSG00000111536. Homo sapiens.
Family and domain databases
Gene3D	1.20.1250.10. 1 hit.
InterPro	IPR009079. 4_helix_cytokine-like_core. IPR012351. 4_helix_cytokine_core. IPR020443. Interleukin-10/19/20/24. IPR020423. Interleukin-10_CS. [Graphical view]
Pfam	PF00726. IL10. 1 hit. [Graphical view]
SMART	SM00188. IL10. 1 hit. [Graphical view]
SUPFAM	SSF47266. 4_helix_cytokine. 1 hit.
PROSITE	PS00520. INTERLEUKIN_10. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	55801.
NextBio	60943.
SOURCE	Search...

Entry information

Entry name

IL26_HUMAN

Accession

Primary (citable) accession number: Q9NPH9

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 16, 2001
Last sequence update:	October 1, 2000
Last modified:	May 1, 2013
This is version 108 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.