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Q9NPH9

- IL26_HUMAN

UniProt

Q9NPH9 - IL26_HUMAN

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Protein
Interleukin-26
Gene
IL26, AK155
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

May play a role in local mechanisms of mucosal immunity and seems to have a proinflammatory function. May play a role in inflammatory bowel disease. Activates STAT1 and STAT3, MAPK1/3 (ERK1/2), JUN and AKT. Induces expression of SOCS3, TNF-alpha and IL-8, secretion of IL-8 and IL-10 and surface expression of ICAM1. Decreases proliferation of intestinal epithelial cells. Is inhibited by heparin.3 Publications

GO - Molecular functioni

  1. cytokine activity Source: UniProtKB

GO - Biological processi

  1. cell-cell signaling Source: ProtInc
  2. negative regulation of epithelial cell proliferation Source: UniProtKB
  3. positive regulation of ERK1 and ERK2 cascade Source: UniProtKB
  4. positive regulation of JAK-STAT cascade Source: UniProtKB
  5. positive regulation of cytokine secretion Source: UniProtKB
  6. positive regulation of protein kinase B signaling Source: UniProtKB
  7. positive regulation of stress-activated MAPK cascade Source: UniProtKB
  8. positive regulation of transcription from RNA polymerase II promoter Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Enzyme and pathway databases

SignaLinkiQ9NPH9.

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-26
Short name:
IL-26
Alternative name(s):
Protein AK155
Gene namesi
Name:IL26
Synonyms:AK155
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 12

Organism-specific databases

HGNCiHGNC:17119. IL26.

Subcellular locationi

Secreted 1 Publication

GO - Cellular componenti

  1. cytosol Source: UniProtKB
  2. extracellular space Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA29826.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121 Reviewed prediction
Add
BLAST
Chaini22 – 171150Interleukin-26
PRO_0000015387Add
BLAST

Proteomic databases

PaxDbiQ9NPH9.
PRIDEiQ9NPH9.

PTM databases

PhosphoSiteiQ9NPH9.

Expressioni

Tissue specificityi

Expressed in HVS transformed T-cells but not other T-cell lines or primary stimulated T-cells. Expressed in colonic T-cells including Th17 inflammatory T-cells; the expression is significantly increased in serum of patients with Crohn's disease (at protein level).1 Publication

Inductioni

By Herpesvirus saimiri infection.

Gene expression databases

BgeeiQ9NPH9.
CleanExiHS_IL26.
GenevestigatoriQ9NPH9.

Interactioni

Subunit structurei

Homodimer.

Protein-protein interaction databases

BioGridi120913. 1 interaction.
STRINGi9606.ENSP00000229134.

Structurei

3D structure databases

ProteinModelPortaliQ9NPH9.
SMRiQ9NPH9. Positions 30-170.

Family & Domainsi

Sequence similaritiesi

Belongs to the IL-10 family.

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG86390.
HOGENOMiHOG000113042.
InParanoidiQ9NPH9.
KOiK05446.
OMAiDILLPWI.
OrthoDBiEOG757CZT.
PhylomeDBiQ9NPH9.
TreeFamiTF333253.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR020443. IL-10/19/20/24/26_fam.
IPR020423. IL-10_CS.
IPR028152. IL-26.
[Graphical view]
PANTHERiPTHR11585. PTHR11585. 1 hit.
PTHR11585:SF8. PTHR11585:SF8. 1 hit.
PfamiPF00726. IL10. 1 hit.
[Graphical view]
SMARTiSM00188. IL10. 1 hit.
[Graphical view]
SUPFAMiSSF47266. SSF47266. 1 hit.
PROSITEiPS00520. INTERLEUKIN_10. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9NPH9-1 [UniParc]FASTAAdd to Basket

« Hide

MLVNFILRCG LLLVTLSLAI AKHKQSSFTK SCYPRGTLSQ AVDALYIKAA    50
WLKATIPEDR IKNIRLLKKK TKKQFMKNCQ FQEQLLSFFM EDVFGQLQLQ 100
GCKKIRFVED FHSLRQKLSH CISCASSARE MKSITRMKRI FYRIGNKGIY 150
KAISELDILL SWIKKLLESS Q 171
Length:171
Mass (Da):19,843
Last modified:October 1, 2000 - v1
Checksum:i31F6261E42B6ACC0
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ251550, AJ251551 Genomic DNA. Translation: CAB77049.1.
AJ251549 mRNA. Translation: CAB76942.1.
AY509906 Genomic DNA. Translation: AAR87776.1.
BC066270 mRNA. Translation: AAH66270.1.
BC066271 mRNA. Translation: AAH66271.1.
CCDSiCCDS8981.1.
RefSeqiNP_060872.1. NM_018402.1.
UniGeneiHs.272350.

Genome annotation databases

EnsembliENST00000229134; ENSP00000229134; ENSG00000111536.
GeneIDi55801.
KEGGihsa:55801.
UCSCiuc001stx.1. human.

Polymorphism databases

DMDMi17366984.

Cross-referencesi

Web resourcesi

Wikipedia

Interleukin-26 entry

SeattleSNPs

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ251550 , AJ251551 Genomic DNA. Translation: CAB77049.1 .
AJ251549 mRNA. Translation: CAB76942.1 .
AY509906 Genomic DNA. Translation: AAR87776.1 .
BC066270 mRNA. Translation: AAH66270.1 .
BC066271 mRNA. Translation: AAH66271.1 .
CCDSi CCDS8981.1.
RefSeqi NP_060872.1. NM_018402.1.
UniGenei Hs.272350.

3D structure databases

ProteinModelPortali Q9NPH9.
SMRi Q9NPH9. Positions 30-170.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 120913. 1 interaction.
STRINGi 9606.ENSP00000229134.

PTM databases

PhosphoSitei Q9NPH9.

Polymorphism databases

DMDMi 17366984.

Proteomic databases

PaxDbi Q9NPH9.
PRIDEi Q9NPH9.

Protocols and materials databases

DNASUi 55801.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000229134 ; ENSP00000229134 ; ENSG00000111536 .
GeneIDi 55801.
KEGGi hsa:55801.
UCSCi uc001stx.1. human.

Organism-specific databases

CTDi 55801.
GeneCardsi GC12M068595.
HGNCi HGNC:17119. IL26.
MIMi 605679. gene.
neXtProti NX_Q9NPH9.
PharmGKBi PA29826.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG86390.
HOGENOMi HOG000113042.
InParanoidi Q9NPH9.
KOi K05446.
OMAi DILLPWI.
OrthoDBi EOG757CZT.
PhylomeDBi Q9NPH9.
TreeFami TF333253.

Enzyme and pathway databases

SignaLinki Q9NPH9.

Miscellaneous databases

GeneWikii Interleukin_26.
GenomeRNAii 55801.
NextBioi 60943.
PROi Q9NPH9.
SOURCEi Search...

Gene expression databases

Bgeei Q9NPH9.
CleanExi HS_IL26.
Genevestigatori Q9NPH9.

Family and domain databases

Gene3Di 1.20.1250.10. 1 hit.
InterProi IPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR020443. IL-10/19/20/24/26_fam.
IPR020423. IL-10_CS.
IPR028152. IL-26.
[Graphical view ]
PANTHERi PTHR11585. PTHR11585. 1 hit.
PTHR11585:SF8. PTHR11585:SF8. 1 hit.
Pfami PF00726. IL10. 1 hit.
[Graphical view ]
SMARTi SM00188. IL10. 1 hit.
[Graphical view ]
SUPFAMi SSF47266. SSF47266. 1 hit.
PROSITEi PS00520. INTERLEUKIN_10. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Induction of a novel cellular homolog of interleukin-10, AK155, by transformation of T lymphocytes with herpesvirus saimiri."
    Knappe A., Hor S., Wittmann S., Fickenscher H.
    J. Virol. 74:3881-3887(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
  2. SeattleSNPs variation discovery resource
    Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. "The T-cell lymphokine interleukin-26 targets epithelial cells through the interleukin-20 receptor 1 and interleukin-10 receptor 2 chains."
    Hor S., Pirzer H., Dumoutier L., Bauer F., Wittmann S., Sticht H., Renauld J.C., de Waal Malefyt R., Fickenscher H.
    J. Biol. Chem. 279:33343-33351(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  5. "IL-26 signals through a novel receptor complex composed of IL-20 receptor 1 and IL-10 receptor 2."
    Sheikh F., Baurin V.V., Lewis-Antes A., Shah N.K., Smirnov S.V., Anantha S., Dickensheets H., Dumoutier L., Renauld J.-C., Zdanov A., Donnelly R.P., Kotenko S.V.
    J. Immunol. 172:2006-2010(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, RECEPTOR-BINDING.
  6. "The role of the novel Th17 cytokine IL-26 in intestinal inflammation."
    Dambacher J., Beigel F., Zitzmann K., De Toni E.N., Goke B., Diepolder H.M., Auernhammer C.J., Brand S.
    Gut 58:1207-1217(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, TISSUE SPECIFICITY, SUBCELLULAR LOCATION.

Entry informationi

Entry nameiIL26_HUMAN
AccessioniPrimary (citable) accession number: Q9NPH9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 16, 2001
Last sequence update: October 1, 2000
Last modified: July 9, 2014
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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