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Q9NPH9

- IL26_HUMAN

UniProt

Q9NPH9 - IL26_HUMAN

Protein

Interleukin-26

Gene

IL26

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    May play a role in local mechanisms of mucosal immunity and seems to have a proinflammatory function. May play a role in inflammatory bowel disease. Activates STAT1 and STAT3, MAPK1/3 (ERK1/2), JUN and AKT. Induces expression of SOCS3, TNF-alpha and IL-8, secretion of IL-8 and IL-10 and surface expression of ICAM1. Decreases proliferation of intestinal epithelial cells. Is inhibited by heparin.3 Publications

    GO - Molecular functioni

    1. cytokine activity Source: UniProtKB

    GO - Biological processi

    1. cell-cell signaling Source: ProtInc
    2. negative regulation of epithelial cell proliferation Source: UniProtKB
    3. positive regulation of cytokine secretion Source: UniProtKB
    4. positive regulation of ERK1 and ERK2 cascade Source: UniProtKB
    5. positive regulation of JAK-STAT cascade Source: UniProtKB
    6. positive regulation of protein kinase B signaling Source: UniProtKB
    7. positive regulation of stress-activated MAPK cascade Source: UniProtKB
    8. positive regulation of transcription from RNA polymerase II promoter Source: UniProtKB

    Keywords - Molecular functioni

    Cytokine

    Enzyme and pathway databases

    SignaLinkiQ9NPH9.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Interleukin-26
    Short name:
    IL-26
    Alternative name(s):
    Protein AK155
    Gene namesi
    Name:IL26
    Synonyms:AK155
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 12

    Organism-specific databases

    HGNCiHGNC:17119. IL26.

    Subcellular locationi

    Secreted 1 Publication

    GO - Cellular componenti

    1. cytosol Source: UniProtKB
    2. extracellular space Source: UniProtKB

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA29826.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2121Sequence AnalysisAdd
    BLAST
    Chaini22 – 171150Interleukin-26PRO_0000015387Add
    BLAST

    Proteomic databases

    PaxDbiQ9NPH9.
    PRIDEiQ9NPH9.

    PTM databases

    PhosphoSiteiQ9NPH9.

    Expressioni

    Tissue specificityi

    Expressed in HVS transformed T-cells but not other T-cell lines or primary stimulated T-cells. Expressed in colonic T-cells including Th17 inflammatory T-cells; the expression is significantly increased in serum of patients with Crohn's disease (at protein level).1 Publication

    Inductioni

    By Herpesvirus saimiri infection.

    Gene expression databases

    BgeeiQ9NPH9.
    CleanExiHS_IL26.
    GenevestigatoriQ9NPH9.

    Interactioni

    Subunit structurei

    Homodimer.

    Protein-protein interaction databases

    BioGridi120913. 1 interaction.
    STRINGi9606.ENSP00000229134.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9NPH9.
    SMRiQ9NPH9. Positions 30-170.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the IL-10 family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG86390.
    HOGENOMiHOG000113042.
    InParanoidiQ9NPH9.
    KOiK05446.
    OMAiDILLPWI.
    OrthoDBiEOG757CZT.
    PhylomeDBiQ9NPH9.
    TreeFamiTF333253.

    Family and domain databases

    Gene3Di1.20.1250.10. 1 hit.
    InterProiIPR009079. 4_helix_cytokine-like_core.
    IPR012351. 4_helix_cytokine_core.
    IPR020443. IL-10/19/20/24/26_fam.
    IPR020423. IL-10_CS.
    IPR028152. IL-26.
    [Graphical view]
    PANTHERiPTHR11585. PTHR11585. 1 hit.
    PTHR11585:SF8. PTHR11585:SF8. 1 hit.
    PfamiPF00726. IL10. 1 hit.
    [Graphical view]
    SMARTiSM00188. IL10. 1 hit.
    [Graphical view]
    SUPFAMiSSF47266. SSF47266. 1 hit.
    PROSITEiPS00520. INTERLEUKIN_10. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9NPH9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLVNFILRCG LLLVTLSLAI AKHKQSSFTK SCYPRGTLSQ AVDALYIKAA    50
    WLKATIPEDR IKNIRLLKKK TKKQFMKNCQ FQEQLLSFFM EDVFGQLQLQ 100
    GCKKIRFVED FHSLRQKLSH CISCASSARE MKSITRMKRI FYRIGNKGIY 150
    KAISELDILL SWIKKLLESS Q 171
    Length:171
    Mass (Da):19,843
    Last modified:October 1, 2000 - v1
    Checksum:i31F6261E42B6ACC0
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ251550, AJ251551 Genomic DNA. Translation: CAB77049.1.
    AJ251549 mRNA. Translation: CAB76942.1.
    AY509906 Genomic DNA. Translation: AAR87776.1.
    BC066270 mRNA. Translation: AAH66270.1.
    BC066271 mRNA. Translation: AAH66271.1.
    CCDSiCCDS8981.1.
    RefSeqiNP_060872.1. NM_018402.1.
    UniGeneiHs.272350.

    Genome annotation databases

    EnsembliENST00000229134; ENSP00000229134; ENSG00000111536.
    GeneIDi55801.
    KEGGihsa:55801.
    UCSCiuc001stx.1. human.

    Polymorphism databases

    DMDMi17366984.

    Cross-referencesi

    Web resourcesi

    Wikipedia

    Interleukin-26 entry

    SeattleSNPs

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ251550 , AJ251551 Genomic DNA. Translation: CAB77049.1 .
    AJ251549 mRNA. Translation: CAB76942.1 .
    AY509906 Genomic DNA. Translation: AAR87776.1 .
    BC066270 mRNA. Translation: AAH66270.1 .
    BC066271 mRNA. Translation: AAH66271.1 .
    CCDSi CCDS8981.1.
    RefSeqi NP_060872.1. NM_018402.1.
    UniGenei Hs.272350.

    3D structure databases

    ProteinModelPortali Q9NPH9.
    SMRi Q9NPH9. Positions 30-170.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 120913. 1 interaction.
    STRINGi 9606.ENSP00000229134.

    PTM databases

    PhosphoSitei Q9NPH9.

    Polymorphism databases

    DMDMi 17366984.

    Proteomic databases

    PaxDbi Q9NPH9.
    PRIDEi Q9NPH9.

    Protocols and materials databases

    DNASUi 55801.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000229134 ; ENSP00000229134 ; ENSG00000111536 .
    GeneIDi 55801.
    KEGGi hsa:55801.
    UCSCi uc001stx.1. human.

    Organism-specific databases

    CTDi 55801.
    GeneCardsi GC12M068595.
    HGNCi HGNC:17119. IL26.
    MIMi 605679. gene.
    neXtProti NX_Q9NPH9.
    PharmGKBi PA29826.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG86390.
    HOGENOMi HOG000113042.
    InParanoidi Q9NPH9.
    KOi K05446.
    OMAi DILLPWI.
    OrthoDBi EOG757CZT.
    PhylomeDBi Q9NPH9.
    TreeFami TF333253.

    Enzyme and pathway databases

    SignaLinki Q9NPH9.

    Miscellaneous databases

    GeneWikii Interleukin_26.
    GenomeRNAii 55801.
    NextBioi 60943.
    PROi Q9NPH9.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9NPH9.
    CleanExi HS_IL26.
    Genevestigatori Q9NPH9.

    Family and domain databases

    Gene3Di 1.20.1250.10. 1 hit.
    InterProi IPR009079. 4_helix_cytokine-like_core.
    IPR012351. 4_helix_cytokine_core.
    IPR020443. IL-10/19/20/24/26_fam.
    IPR020423. IL-10_CS.
    IPR028152. IL-26.
    [Graphical view ]
    PANTHERi PTHR11585. PTHR11585. 1 hit.
    PTHR11585:SF8. PTHR11585:SF8. 1 hit.
    Pfami PF00726. IL10. 1 hit.
    [Graphical view ]
    SMARTi SM00188. IL10. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47266. SSF47266. 1 hit.
    PROSITEi PS00520. INTERLEUKIN_10. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Induction of a novel cellular homolog of interleukin-10, AK155, by transformation of T lymphocytes with herpesvirus saimiri."
      Knappe A., Hor S., Wittmann S., Fickenscher H.
      J. Virol. 74:3881-3887(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
    2. SeattleSNPs variation discovery resource
      Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    4. "The T-cell lymphokine interleukin-26 targets epithelial cells through the interleukin-20 receptor 1 and interleukin-10 receptor 2 chains."
      Hor S., Pirzer H., Dumoutier L., Bauer F., Wittmann S., Sticht H., Renauld J.C., de Waal Malefyt R., Fickenscher H.
      J. Biol. Chem. 279:33343-33351(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    5. "IL-26 signals through a novel receptor complex composed of IL-20 receptor 1 and IL-10 receptor 2."
      Sheikh F., Baurin V.V., Lewis-Antes A., Shah N.K., Smirnov S.V., Anantha S., Dickensheets H., Dumoutier L., Renauld J.-C., Zdanov A., Donnelly R.P., Kotenko S.V.
      J. Immunol. 172:2006-2010(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, RECEPTOR-BINDING.
    6. "The role of the novel Th17 cytokine IL-26 in intestinal inflammation."
      Dambacher J., Beigel F., Zitzmann K., De Toni E.N., Goke B., Diepolder H.M., Auernhammer C.J., Brand S.
      Gut 58:1207-1217(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, TISSUE SPECIFICITY, SUBCELLULAR LOCATION.

    Entry informationi

    Entry nameiIL26_HUMAN
    AccessioniPrimary (citable) accession number: Q9NPH9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 16, 2001
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 119 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 12
      Human chromosome 12: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3