ID   OBP2B_HUMAN             Reviewed;         170 AA.
AC   Q9NPH6; Q5VSP6; Q9NY51; Q9NY52;
DT   03-APR-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   24-JAN-2024, entry version 159.
DE   RecName: Full=Odorant-binding protein 2b;
DE   AltName: Full=Odorant-binding protein IIb;
DE            Short=OBPIIb;
DE   Flags: Precursor;
GN   Name=OBP2B; ORFNames=UNQ653/PRO1283;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORMS BA; BB AND BG).
RX   PubMed=10607840; DOI=10.1093/hmg/9.2.289;
RA   Lacazette E., Gachon A.-M., Pitiot G.;
RT   "A novel human odorant-binding protein gene family resulting from genomic
RT   duplicons at 9q34: differential expression in the oral and genital
RT   spheres.";
RL   Hum. Mol. Genet. 9:289-301(2000).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM BA).
RX   PubMed=12975309; DOI=10.1101/gr.1293003;
RA   Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA   Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA   Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., Huang A.,
RA   Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D.,
RA   Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L.,
RA   Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C.,
RA   Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J.,
RA   Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.;
RT   "The secreted protein discovery initiative (SPDI), a large-scale effort to
RT   identify novel human secreted and transmembrane proteins: a bioinformatics
RT   assessment.";
RL   Genome Res. 13:2265-2270(2003).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15164053; DOI=10.1038/nature02465;
RA   Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L.,
RA   Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R.,
RA   Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S.,
RA   Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K.,
RA   Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y.,
RA   Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C.,
RA   Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E.,
RA   Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M.,
RA   Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J.,
RA   Frankish A., Frankland J.A., French L., Fricker D.G., Garner P.,
RA   Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S.,
RA   Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E.,
RA   Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D.,
RA   Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E.,
RA   Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K.,
RA   Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S.,
RA   Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J.,
RA   Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E.,
RA   McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V.,
RA   Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S.,
RA   Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K.,
RA   Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J.,
RA   Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M.,
RA   West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L.,
RA   Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M.,
RA   Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J.,
RA   Dunham I.;
RT   "DNA sequence and analysis of human chromosome 9.";
RL   Nature 429:369-374(2004).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM BA).
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Probably binds and transports small hydrophobic volatile
CC       molecules.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=3;
CC       Name=Ba;
CC         IsoId=Q9NPH6-1; Sequence=Displayed;
CC       Name=Bb;
CC         IsoId=Q9NPH6-2; Sequence=VSP_003138;
CC       Name=Bg;
CC         IsoId=Q9NPH6-3; Sequence=VSP_003139;
CC   -!- TISSUE SPECIFICITY: Strongly expressed in genital sphere organs such as
CC       the prostate and mammary glands.
CC   -!- SIMILARITY: Belongs to the calycin superfamily. Lipocalin family.
CC       {ECO:0000305}.
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DR   EMBL; AJ251025; CAB71322.1; -; Genomic_DNA.
DR   EMBL; AJ251026; CAB71323.1; -; mRNA.
DR   EMBL; AJ251027; CAB71324.1; -; mRNA.
DR   EMBL; AJ251028; CAB71325.1; -; mRNA.
DR   EMBL; AY358981; AAQ89340.1; -; mRNA.
DR   EMBL; AL732364; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC096717; AAH96717.1; -; mRNA.
DR   EMBL; BC098125; AAH98125.1; -; mRNA.
DR   EMBL; BC098151; AAH98151.1; -; mRNA.
DR   EMBL; BC098340; AAH98340.1; -; mRNA.
DR   CCDS; CCDS6961.1; -. [Q9NPH6-1]
DR   RefSeq; NP_001275916.1; NM_001288987.1. [Q9NPH6-1]
DR   RefSeq; NP_055396.1; NM_014581.3. [Q9NPH6-1]
DR   AlphaFoldDB; Q9NPH6; -.
DR   SMR; Q9NPH6; -.
DR   BioGRID; 119014; 2.
DR   IntAct; Q9NPH6; 1.
DR   STRING; 9606.ENSP00000484615; -.
DR   iPTMnet; Q9NPH6; -.
DR   PhosphoSitePlus; Q9NPH6; -.
DR   BioMuta; OBP2B; -.
DR   MassIVE; Q9NPH6; -.
DR   PaxDb; 9606-ENSP00000484615; -.
DR   PeptideAtlas; Q9NPH6; -.
DR   ProteomicsDB; 82010; -. [Q9NPH6-1]
DR   TopDownProteomics; Q9NPH6-2; -. [Q9NPH6-2]
DR   TopDownProteomics; Q9NPH6-3; -. [Q9NPH6-3]
DR   Antibodypedia; 63951; 36 antibodies from 8 providers.
DR   DNASU; 29989; -.
DR   Ensembl; ENST00000372034.8; ENSP00000361104.3; ENSG00000171102.16. [Q9NPH6-1]
DR   Ensembl; ENST00000473737.5; ENSP00000434927.1; ENSG00000171102.16. [Q9NPH6-2]
DR   Ensembl; ENST00000618116.4; ENSP00000484615.1; ENSG00000171102.16. [Q9NPH6-1]
DR   Ensembl; ENST00000627758.2; ENSP00000487521.1; ENSG00000280584.3. [Q9NPH6-1]
DR   Ensembl; ENST00000628865.2; ENSP00000486108.1; ENSG00000280584.3. [Q9NPH6-1]
DR   Ensembl; ENST00000630166.2; ENSP00000486815.1; ENSG00000280584.3. [Q9NPH6-2]
DR   GeneID; 29989; -.
DR   KEGG; hsa:29989; -.
DR   MANE-Select; ENST00000372034.8; ENSP00000361104.3; NM_014581.4; NP_055396.1.
DR   UCSC; uc004ccz.5; human. [Q9NPH6-1]
DR   AGR; HGNC:23381; -.
DR   CTD; 29989; -.
DR   DisGeNET; 29989; -.
DR   GeneCards; OBP2B; -.
DR   HGNC; HGNC:23381; OBP2B.
DR   HPA; ENSG00000171102; Tissue enhanced (skin, testis).
DR   MIM; 604606; gene.
DR   neXtProt; NX_Q9NPH6; -.
DR   OpenTargets; ENSG00000171102; -.
DR   PharmGKB; PA134883553; -.
DR   VEuPathDB; HostDB:ENSG00000171102; -.
DR   eggNOG; ENOG502S22P; Eukaryota.
DR   GeneTree; ENSGT01050000244868; -.
DR   HOGENOM; CLU_125034_0_0_1; -.
DR   InParanoid; Q9NPH6; -.
DR   OMA; DHFVFYC; -.
DR   OrthoDB; 4660635at2759; -.
DR   PhylomeDB; Q9NPH6; -.
DR   TreeFam; TF338197; -.
DR   PathwayCommons; Q9NPH6; -.
DR   SignaLink; Q9NPH6; -.
DR   BioGRID-ORCS; 29989; 7 hits in 714 CRISPR screens.
DR   GenomeRNAi; 29989; -.
DR   Pharos; Q9NPH6; Tdark.
DR   PRO; PR:Q9NPH6; -.
DR   Proteomes; UP000005640; Chromosome 9.
DR   RNAct; Q9NPH6; Protein.
DR   Bgee; ENSG00000171102; Expressed in right testis and 49 other cell types or tissues.
DR   ExpressionAtlas; Q9NPH6; baseline and differential.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0005549; F:odorant binding; NAS:UniProtKB.
DR   GO; GO:0036094; F:small molecule binding; IEA:InterPro.
DR   GO; GO:0007635; P:chemosensory behavior; TAS:ProtInc.
DR   GO; GO:0007608; P:sensory perception of smell; NAS:UniProtKB.
DR   CDD; cd19414; lipocalin_1_3_4_13-like; 1.
DR   Gene3D; 2.40.128.20; -; 1.
DR   InterPro; IPR012674; Calycin.
DR   InterPro; IPR002345; Lipocalin.
DR   InterPro; IPR000566; Lipocln_cytosolic_FA-bd_dom.
DR   InterPro; IPR002450; von_Ebner_gland.
DR   PANTHER; PTHR11430; LIPOCALIN; 1.
DR   PANTHER; PTHR11430:SF129; ODORANT-BINDING PROTEIN 2A-RELATED; 1.
DR   Pfam; PF00061; Lipocalin; 1.
DR   PRINTS; PR01175; VNEBNERGLAND.
DR   SUPFAM; SSF50814; Lipocalins; 1.
DR   Genevisible; Q9NPH6; HS.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Disulfide bond; Olfaction; Reference proteome;
KW   Secreted; Sensory transduction; Signal; Transport.
FT   SIGNAL          1..15
FT                   /evidence="ECO:0000255"
FT   CHAIN           16..170
FT                   /note="Odorant-binding protein 2b"
FT                   /id="PRO_0000017938"
FT   DISULFID        74..166
FT                   /evidence="ECO:0000250"
FT   VAR_SEQ         25..170
FT                   /note="ITGTWYVKAMVVDKDFPEDRRPRKVSPVKVTALGGGKLEATFTFMREDRCIQ
FT                   KKILMRKTEEPGKYSAYGGRKLMYLQELPRRDHYIFYCKDQHHGGLLHMGKLVGRNSDT
FT                   NREALEEFKKLVQRKGLSEEDIFTPLQTGSCVPEH -> EGGSVHPEENPDAEDGGAWQ
FT                   IQRLWGQEAHIPAGAAQEGPLHLLLQRPAPWGPAPHGKACG (in isoform Bg)"
FT                   /evidence="ECO:0000303|PubMed:10607840"
FT                   /id="VSP_003139"
FT   VAR_SEQ         93..170
FT                   /note="YGGRKLMYLQELPRRDHYIFYCKDQHHGGLLHMGKLVGRNSDTNREALEEFK
FT                   KLVQRKGLSEEDIFTPLQTGSCVPEH -> CLSAVEMDQITPALWEALAIDTLRKLRIG
FT                   TRRPRIRWGQEAHVPAGAAQEGPLHLLLQRPAPWGPAPHGKACG (in isoform
FT                   Bb)"
FT                   /evidence="ECO:0000303|PubMed:10607840"
FT                   /id="VSP_003138"
FT   VARIANT         167
FT                   /note="V -> I (in dbSNP:rs11244035)"
FT                   /id="VAR_050177"
SQ   SEQUENCE   170 AA;  19457 MW;  344FBC37E70739C1 CRC64;
     MKTLFLGVTL GLAAALSFTL EEEDITGTWY VKAMVVDKDF PEDRRPRKVS PVKVTALGGG
     KLEATFTFMR EDRCIQKKIL MRKTEEPGKY SAYGGRKLMY LQELPRRDHY IFYCKDQHHG
     GLLHMGKLVG RNSDTNREAL EEFKKLVQRK GLSEEDIFTP LQTGSCVPEH
//