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Q9NPH6

- OBP2B_HUMAN

UniProt

Q9NPH6 - OBP2B_HUMAN

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Protein

Odorant-binding protein 2b

Gene

OBP2B

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Probably binds and transports small hydrophobic volatile molecules.

GO - Molecular functioni

  1. odorant binding Source: UniProtKB

GO - Biological processi

  1. chemosensory behavior Source: ProtInc
  2. sensory perception of smell Source: UniProtKB
  3. transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Olfaction, Sensory transduction, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Odorant-binding protein 2b
Alternative name(s):
Odorant-binding protein IIb
Short name:
OBPIIb
Gene namesi
Name:OBP2B
ORF Names:UNQ653/PRO1283
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 9

Organism-specific databases

HGNCiHGNC:23381. OBP2B.

Subcellular locationi

Secreted Curated

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134883553.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1515Sequence AnalysisAdd
BLAST
Chaini16 – 170155Odorant-binding protein 2bPRO_0000017938Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi74 ↔ 166By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PRIDEiQ9NPH6.

Expressioni

Tissue specificityi

Strongly expressed in genital sphere organs such as the prostate and mammary glands.

Gene expression databases

BgeeiQ9NPH6.
CleanExiHS_OBP2B.
GenevestigatoriQ9NPH6.

Interactioni

Protein-protein interaction databases

BioGridi119014. 2 interactions.
STRINGi9606.ENSP00000361104.

Structurei

3D structure databases

ProteinModelPortaliQ9NPH6.
SMRiQ9NPH6. Positions 25-168.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the calycin superfamily. Lipocalin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG28920.
GeneTreeiENSGT00440000033563.
HOGENOMiHOG000231562.
HOVERGENiHBG101411.
InParanoidiQ9NPH6.
OMAiGSCVPEH.
PhylomeDBiQ9NPH6.
TreeFamiTF338197.

Family and domain databases

Gene3Di2.40.128.20. 1 hit.
InterProiIPR012674. Calycin.
IPR011038. Calycin-like.
IPR000566. Lipocln_cytosolic_FA-bd_dom.
IPR002450. von_Ebner_gland.
[Graphical view]
PfamiPF00061. Lipocalin. 1 hit.
[Graphical view]
PRINTSiPR01175. VNEBNERGLAND.
SUPFAMiSSF50814. SSF50814. 1 hit.

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform Ba (identifier: Q9NPH6-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKTLFLGVTL GLAAALSFTL EEEDITGTWY VKAMVVDKDF PEDRRPRKVS
60 70 80 90 100
PVKVTALGGG KLEATFTFMR EDRCIQKKIL MRKTEEPGKY SAYGGRKLMY
110 120 130 140 150
LQELPRRDHY IFYCKDQHHG GLLHMGKLVG RNSDTNREAL EEFKKLVQRK
160 170
GLSEEDIFTP LQTGSCVPEH
Length:170
Mass (Da):19,457
Last modified:October 1, 2000 - v1
Checksum:i344FBC37E70739C1
GO
Isoform Bb (identifier: Q9NPH6-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     93-170: YGGRKLMYLQ...LQTGSCVPEH → CLSAVEMDQI...GPAPHGKACG

Show »
Length:165
Mass (Da):18,292
Checksum:i3F867F5F12F1018E
GO
Isoform Bg (identifier: Q9NPH6-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     25-170: ITGTWYVKAM...LQTGSCVPEH → EGGSVHPEEN...GPAPHGKACG

Show »
Length:85
Mass (Da):8,946
Checksum:i1F8189B2FFFA0B2E
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti167 – 1671V → I.
Corresponds to variant rs11244035 [ dbSNP | Ensembl ].
VAR_050177

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei25 – 170146ITGTW…CVPEH → EGGSVHPEENPDAEDGGAWQ IQRLWGQEAHIPAGAAQEGP LHLLLQRPAPWGPAPHGKAC G in isoform Bg. 1 PublicationVSP_003139Add
BLAST
Alternative sequencei93 – 17078YGGRK…CVPEH → CLSAVEMDQITPALWEALAI DTLRKLRIGTRRPRIRWGQE AHVPAGAAQEGPLHLLLQRP APWGPAPHGKACG in isoform Bb. 1 PublicationVSP_003138Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ251025 Genomic DNA. Translation: CAB71322.1.
AJ251026 mRNA. Translation: CAB71323.1.
AJ251027 mRNA. Translation: CAB71324.1.
AJ251028 mRNA. Translation: CAB71325.1.
AY358981 mRNA. Translation: AAQ89340.1.
AL732364 Genomic DNA. Translation: CAH73779.1.
BC096717 mRNA. Translation: AAH96717.1.
BC098125 mRNA. Translation: AAH98125.1.
BC098151 mRNA. Translation: AAH98151.1.
BC098340 mRNA. Translation: AAH98340.1.
CCDSiCCDS6961.1. [Q9NPH6-1]
RefSeqiNP_001275916.1. NM_001288987.1. [Q9NPH6-1]
NP_055396.1. NM_014581.3. [Q9NPH6-1]
UniGeneiHs.449629.

Genome annotation databases

EnsembliENST00000372034; ENSP00000361104; ENSG00000171102. [Q9NPH6-1]
ENST00000473737; ENSP00000434927; ENSG00000171102. [Q9NPH6-2]
ENST00000618116; ENSP00000484615; ENSG00000171102. [Q9NPH6-1]
GeneIDi29989.
KEGGihsa:29989.
UCSCiuc004ccz.3. human. [Q9NPH6-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ251025 Genomic DNA. Translation: CAB71322.1 .
AJ251026 mRNA. Translation: CAB71323.1 .
AJ251027 mRNA. Translation: CAB71324.1 .
AJ251028 mRNA. Translation: CAB71325.1 .
AY358981 mRNA. Translation: AAQ89340.1 .
AL732364 Genomic DNA. Translation: CAH73779.1 .
BC096717 mRNA. Translation: AAH96717.1 .
BC098125 mRNA. Translation: AAH98125.1 .
BC098151 mRNA. Translation: AAH98151.1 .
BC098340 mRNA. Translation: AAH98340.1 .
CCDSi CCDS6961.1. [Q9NPH6-1 ]
RefSeqi NP_001275916.1. NM_001288987.1. [Q9NPH6-1 ]
NP_055396.1. NM_014581.3. [Q9NPH6-1 ]
UniGenei Hs.449629.

3D structure databases

ProteinModelPortali Q9NPH6.
SMRi Q9NPH6. Positions 25-168.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 119014. 2 interactions.
STRINGi 9606.ENSP00000361104.

Proteomic databases

PRIDEi Q9NPH6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000372034 ; ENSP00000361104 ; ENSG00000171102 . [Q9NPH6-1 ]
ENST00000473737 ; ENSP00000434927 ; ENSG00000171102 . [Q9NPH6-2 ]
ENST00000618116 ; ENSP00000484615 ; ENSG00000171102 . [Q9NPH6-1 ]
GeneIDi 29989.
KEGGi hsa:29989.
UCSCi uc004ccz.3. human. [Q9NPH6-1 ]

Organism-specific databases

CTDi 29989.
GeneCardsi GC09M136080.
HGNCi HGNC:23381. OBP2B.
MIMi 604606. gene.
neXtProti NX_Q9NPH6.
PharmGKBi PA134883553.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG28920.
GeneTreei ENSGT00440000033563.
HOGENOMi HOG000231562.
HOVERGENi HBG101411.
InParanoidi Q9NPH6.
OMAi GSCVPEH.
PhylomeDBi Q9NPH6.
TreeFami TF338197.

Miscellaneous databases

GenomeRNAii 29989.
NextBioi 52764.
PROi Q9NPH6.
SOURCEi Search...

Gene expression databases

Bgeei Q9NPH6.
CleanExi HS_OBP2B.
Genevestigatori Q9NPH6.

Family and domain databases

Gene3Di 2.40.128.20. 1 hit.
InterProi IPR012674. Calycin.
IPR011038. Calycin-like.
IPR000566. Lipocln_cytosolic_FA-bd_dom.
IPR002450. von_Ebner_gland.
[Graphical view ]
Pfami PF00061. Lipocalin. 1 hit.
[Graphical view ]
PRINTSi PR01175. VNEBNERGLAND.
SUPFAMi SSF50814. SSF50814. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A novel human odorant-binding protein gene family resulting from genomic duplicons at 9q34: differential expression in the oral and genital spheres."
    Lacazette E., Gachon A.-M., Pitiot G.
    Hum. Mol. Genet. 9:289-301(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORMS BA; BB AND BG).
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM BA).
  3. "DNA sequence and analysis of human chromosome 9."
    Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
    , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
    Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM BA).

Entry informationi

Entry nameiOBP2B_HUMAN
AccessioniPrimary (citable) accession number: Q9NPH6
Secondary accession number(s): Q5VSP6, Q9NY51, Q9NY52
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 3, 2002
Last sequence update: October 1, 2000
Last modified: October 29, 2014
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3