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Q9NPH6

- OBP2B_HUMAN

UniProt

Q9NPH6 - OBP2B_HUMAN

Protein

Odorant-binding protein 2b

Gene

OBP2B

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    Probably binds and transports small hydrophobic volatile molecules.

    GO - Molecular functioni

    1. odorant binding Source: UniProtKB

    GO - Biological processi

    1. chemosensory behavior Source: ProtInc
    2. sensory perception of smell Source: UniProtKB
    3. transport Source: UniProtKB-KW

    Keywords - Biological processi

    Olfaction, Sensory transduction, Transport

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Odorant-binding protein 2b
    Alternative name(s):
    Odorant-binding protein IIb
    Short name:
    OBPIIb
    Gene namesi
    Name:OBP2B
    ORF Names:UNQ653/PRO1283
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 9

    Organism-specific databases

    HGNCiHGNC:23381. OBP2B.

    Subcellular locationi

    Secreted Curated

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134883553.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1515Sequence AnalysisAdd
    BLAST
    Chaini16 – 170155Odorant-binding protein 2bPRO_0000017938Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi74 ↔ 166By similarity

    Keywords - PTMi

    Disulfide bond

    Proteomic databases

    PRIDEiQ9NPH6.

    Expressioni

    Tissue specificityi

    Strongly expressed in genital sphere organs such as the prostate and mammary glands.

    Gene expression databases

    ArrayExpressiQ9NPH6.
    BgeeiQ9NPH6.
    CleanExiHS_OBP2B.
    GenevestigatoriQ9NPH6.

    Interactioni

    Protein-protein interaction databases

    BioGridi119014. 1 interaction.
    STRINGi9606.ENSP00000361104.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9NPH6.
    SMRiQ9NPH6. Positions 25-168.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the calycin superfamily. Lipocalin family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG28920.
    HOGENOMiHOG000231562.
    HOVERGENiHBG101411.
    InParanoidiQ9NPH6.
    OMAiGSCVPEH.
    PhylomeDBiQ9NPH6.
    TreeFamiTF338197.

    Family and domain databases

    Gene3Di2.40.128.20. 1 hit.
    InterProiIPR012674. Calycin.
    IPR011038. Calycin-like.
    IPR000566. Lipocln_cytosolic_FA-bd_dom.
    IPR002450. von_Ebner_gland.
    [Graphical view]
    PfamiPF00061. Lipocalin. 1 hit.
    [Graphical view]
    PRINTSiPR01175. VNEBNERGLAND.
    SUPFAMiSSF50814. SSF50814. 1 hit.

    Sequences (3)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform Ba (identifier: Q9NPH6-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MKTLFLGVTL GLAAALSFTL EEEDITGTWY VKAMVVDKDF PEDRRPRKVS    50
    PVKVTALGGG KLEATFTFMR EDRCIQKKIL MRKTEEPGKY SAYGGRKLMY 100
    LQELPRRDHY IFYCKDQHHG GLLHMGKLVG RNSDTNREAL EEFKKLVQRK 150
    GLSEEDIFTP LQTGSCVPEH 170
    Length:170
    Mass (Da):19,457
    Last modified:October 1, 2000 - v1
    Checksum:i344FBC37E70739C1
    GO
    Isoform Bb (identifier: Q9NPH6-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         93-170: YGGRKLMYLQ...LQTGSCVPEH → CLSAVEMDQI...GPAPHGKACG

    Show »
    Length:165
    Mass (Da):18,292
    Checksum:i3F867F5F12F1018E
    GO
    Isoform Bg (identifier: Q9NPH6-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         25-170: ITGTWYVKAM...LQTGSCVPEH → EGGSVHPEEN...GPAPHGKACG

    Show »
    Length:85
    Mass (Da):8,946
    Checksum:i1F8189B2FFFA0B2E
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti167 – 1671V → I.
    Corresponds to variant rs11244035 [ dbSNP | Ensembl ].
    VAR_050177

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei25 – 170146ITGTW…CVPEH → EGGSVHPEENPDAEDGGAWQ IQRLWGQEAHIPAGAAQEGP LHLLLQRPAPWGPAPHGKAC G in isoform Bg. 1 PublicationVSP_003139Add
    BLAST
    Alternative sequencei93 – 17078YGGRK…CVPEH → CLSAVEMDQITPALWEALAI DTLRKLRIGTRRPRIRWGQE AHVPAGAAQEGPLHLLLQRP APWGPAPHGKACG in isoform Bb. 1 PublicationVSP_003138Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ251025 Genomic DNA. Translation: CAB71322.1.
    AJ251026 mRNA. Translation: CAB71323.1.
    AJ251027 mRNA. Translation: CAB71324.1.
    AJ251028 mRNA. Translation: CAB71325.1.
    AY358981 mRNA. Translation: AAQ89340.1.
    AL732364 Genomic DNA. Translation: CAH73779.1.
    BC096717 mRNA. Translation: AAH96717.1.
    BC098125 mRNA. Translation: AAH98125.1.
    BC098151 mRNA. Translation: AAH98151.1.
    BC098340 mRNA. Translation: AAH98340.1.
    CCDSiCCDS6961.1. [Q9NPH6-1]
    RefSeqiNP_001275916.1. NM_001288987.1. [Q9NPH6-1]
    NP_055396.1. NM_014581.3. [Q9NPH6-1]
    UniGeneiHs.449629.

    Genome annotation databases

    EnsembliENST00000372034; ENSP00000361104; ENSG00000171102. [Q9NPH6-1]
    ENST00000473737; ENSP00000434927; ENSG00000171102. [Q9NPH6-2]
    GeneIDi29989.
    KEGGihsa:29989.
    UCSCiuc004ccz.3. human. [Q9NPH6-1]

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ251025 Genomic DNA. Translation: CAB71322.1 .
    AJ251026 mRNA. Translation: CAB71323.1 .
    AJ251027 mRNA. Translation: CAB71324.1 .
    AJ251028 mRNA. Translation: CAB71325.1 .
    AY358981 mRNA. Translation: AAQ89340.1 .
    AL732364 Genomic DNA. Translation: CAH73779.1 .
    BC096717 mRNA. Translation: AAH96717.1 .
    BC098125 mRNA. Translation: AAH98125.1 .
    BC098151 mRNA. Translation: AAH98151.1 .
    BC098340 mRNA. Translation: AAH98340.1 .
    CCDSi CCDS6961.1. [Q9NPH6-1 ]
    RefSeqi NP_001275916.1. NM_001288987.1. [Q9NPH6-1 ]
    NP_055396.1. NM_014581.3. [Q9NPH6-1 ]
    UniGenei Hs.449629.

    3D structure databases

    ProteinModelPortali Q9NPH6.
    SMRi Q9NPH6. Positions 25-168.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 119014. 1 interaction.
    STRINGi 9606.ENSP00000361104.

    Proteomic databases

    PRIDEi Q9NPH6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000372034 ; ENSP00000361104 ; ENSG00000171102 . [Q9NPH6-1 ]
    ENST00000473737 ; ENSP00000434927 ; ENSG00000171102 . [Q9NPH6-2 ]
    GeneIDi 29989.
    KEGGi hsa:29989.
    UCSCi uc004ccz.3. human. [Q9NPH6-1 ]

    Organism-specific databases

    CTDi 29989.
    GeneCardsi GC09M136080.
    HGNCi HGNC:23381. OBP2B.
    MIMi 604606. gene.
    neXtProti NX_Q9NPH6.
    PharmGKBi PA134883553.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG28920.
    HOGENOMi HOG000231562.
    HOVERGENi HBG101411.
    InParanoidi Q9NPH6.
    OMAi GSCVPEH.
    PhylomeDBi Q9NPH6.
    TreeFami TF338197.

    Miscellaneous databases

    GenomeRNAii 29989.
    NextBioi 52764.
    PROi Q9NPH6.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9NPH6.
    Bgeei Q9NPH6.
    CleanExi HS_OBP2B.
    Genevestigatori Q9NPH6.

    Family and domain databases

    Gene3Di 2.40.128.20. 1 hit.
    InterProi IPR012674. Calycin.
    IPR011038. Calycin-like.
    IPR000566. Lipocln_cytosolic_FA-bd_dom.
    IPR002450. von_Ebner_gland.
    [Graphical view ]
    Pfami PF00061. Lipocalin. 1 hit.
    [Graphical view ]
    PRINTSi PR01175. VNEBNERGLAND.
    SUPFAMi SSF50814. SSF50814. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "A novel human odorant-binding protein gene family resulting from genomic duplicons at 9q34: differential expression in the oral and genital spheres."
      Lacazette E., Gachon A.-M., Pitiot G.
      Hum. Mol. Genet. 9:289-301(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORMS BA; BB AND BG).
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM BA).
    3. "DNA sequence and analysis of human chromosome 9."
      Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
      , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
      Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM BA).

    Entry informationi

    Entry nameiOBP2B_HUMAN
    AccessioniPrimary (citable) accession number: Q9NPH6
    Secondary accession number(s): Q5VSP6, Q9NY51, Q9NY52
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 3, 2002
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 106 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 9
      Human chromosome 9: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3