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Q9NPH6 (OBP2B_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 105. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Odorant-binding protein 2b
Alternative name(s):
Odorant-binding protein IIb
Short name=OBPIIb
Gene names
Name:OBP2B
ORF Names:UNQ653/PRO1283
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length170 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Probably binds and transports small hydrophobic volatile molecules.

Subcellular location

Secreted Probable.

Tissue specificity

Strongly expressed in genital sphere organs such as the prostate and mammary glands.

Sequence similarities

Belongs to the calycin superfamily. Lipocalin family.

Ontologies

Keywords
   Biological processOlfaction
Sensory transduction
Transport
   Cellular componentSecreted
   Coding sequence diversityAlternative splicing
Polymorphism
   DomainSignal
   PTMDisulfide bond
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processchemosensory behavior

Traceable author statement Ref.1. Source: ProtInc

sensory perception of smell

Non-traceable author statement Ref.1. Source: UniProtKB

transport

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionodorant binding

Non-traceable author statement Ref.1. Source: UniProtKB

Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform Ba (identifier: Q9NPH6-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform Bb (identifier: Q9NPH6-2)

The sequence of this isoform differs from the canonical sequence as follows:
     93-170: YGGRKLMYLQ...LQTGSCVPEH → CLSAVEMDQI...GPAPHGKACG
Isoform Bg (identifier: Q9NPH6-3)

The sequence of this isoform differs from the canonical sequence as follows:
     25-170: ITGTWYVKAM...LQTGSCVPEH → EGGSVHPEEN...GPAPHGKACG

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1515 Potential
Chain16 – 170155Odorant-binding protein 2b
PRO_0000017938

Amino acid modifications

Disulfide bond74 ↔ 166 By similarity

Natural variations

Alternative sequence25 – 170146ITGTW…CVPEH → EGGSVHPEENPDAEDGGAWQ IQRLWGQEAHIPAGAAQEGP LHLLLQRPAPWGPAPHGKAC G in isoform Bg.
VSP_003139
Alternative sequence93 – 17078YGGRK…CVPEH → CLSAVEMDQITPALWEALAI DTLRKLRIGTRRPRIRWGQE AHVPAGAAQEGPLHLLLQRP APWGPAPHGKACG in isoform Bb.
VSP_003138
Natural variant1671V → I.
Corresponds to variant rs11244035 [ dbSNP | Ensembl ].
VAR_050177

Sequences

Sequence LengthMass (Da)Tools
Isoform Ba [UniParc].

Last modified October 1, 2000. Version 1.
Checksum: 344FBC37E70739C1

FASTA17019,457
        10         20         30         40         50         60 
MKTLFLGVTL GLAAALSFTL EEEDITGTWY VKAMVVDKDF PEDRRPRKVS PVKVTALGGG 

        70         80         90        100        110        120 
KLEATFTFMR EDRCIQKKIL MRKTEEPGKY SAYGGRKLMY LQELPRRDHY IFYCKDQHHG 

       130        140        150        160        170 
GLLHMGKLVG RNSDTNREAL EEFKKLVQRK GLSEEDIFTP LQTGSCVPEH 

« Hide

Isoform Bb [UniParc].

Checksum: 3F867F5F12F1018E
Show »

FASTA16518,292
Isoform Bg [UniParc].

Checksum: 1F8189B2FFFA0B2E
Show »

FASTA858,946

References

« Hide 'large scale' references
[1]"A novel human odorant-binding protein gene family resulting from genomic duplicons at 9q34: differential expression in the oral and genital spheres."
Lacazette E., Gachon A.-M., Pitiot G.
Hum. Mol. Genet. 9:289-301(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORMS BA; BB AND BG).
[2]"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. expand/collapse author list , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.
Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM BA).
[3]"DNA sequence and analysis of human chromosome 9."
Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L. expand/collapse author list , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM BA).

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ251025 Genomic DNA. Translation: CAB71322.1.
AJ251026 mRNA. Translation: CAB71323.1.
AJ251027 mRNA. Translation: CAB71324.1.
AJ251028 mRNA. Translation: CAB71325.1.
AY358981 mRNA. Translation: AAQ89340.1.
AL732364 Genomic DNA. Translation: CAH73779.1.
BC096717 mRNA. Translation: AAH96717.1.
BC098125 mRNA. Translation: AAH98125.1.
BC098151 mRNA. Translation: AAH98151.1.
BC098340 mRNA. Translation: AAH98340.1.
CCDSCCDS6961.1. [Q9NPH6-1]
RefSeqNP_001275916.1. NM_001288987.1. [Q9NPH6-1]
NP_055396.1. NM_014581.3. [Q9NPH6-1]
UniGeneHs.449629.

3D structure databases

ProteinModelPortalQ9NPH6.
SMRQ9NPH6. Positions 25-168.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid119014. 1 interaction.
STRING9606.ENSP00000361104.

Proteomic databases

PRIDEQ9NPH6.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000372034; ENSP00000361104; ENSG00000171102. [Q9NPH6-1]
ENST00000473737; ENSP00000434927; ENSG00000171102. [Q9NPH6-2]
ENST00000562137; ENSP00000457426; ENSG00000261059. [Q9NPH6-1]
ENST00000562329; ENSP00000457738; ENSG00000261059. [Q9NPH6-2]
GeneID29989.
KEGGhsa:29989.
UCSCuc004ccz.3. human. [Q9NPH6-1]

Organism-specific databases

CTD29989.
GeneCardsGC09M136080.
HGNCHGNC:23381. OBP2B.
MIM604606. gene.
neXtProtNX_Q9NPH6.
PharmGKBPA134883553.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG28920.
HOGENOMHOG000231562.
HOVERGENHBG101411.
InParanoidQ9NPH6.
OMAGSCVPEH.
PhylomeDBQ9NPH6.
TreeFamTF338197.

Gene expression databases

ArrayExpressQ9NPH6.
BgeeQ9NPH6.
CleanExHS_OBP2B.
GenevestigatorQ9NPH6.

Family and domain databases

Gene3D2.40.128.20. 1 hit.
InterProIPR012674. Calycin.
IPR011038. Calycin-like.
IPR000566. Lipocln_cytosolic_FA-bd_dom.
IPR002450. von_Ebner_gland.
[Graphical view]
PfamPF00061. Lipocalin. 1 hit.
[Graphical view]
PRINTSPR01175. VNEBNERGLAND.
SUPFAMSSF50814. SSF50814. 1 hit.
ProtoNetSearch...

Other

GenomeRNAi29989.
NextBio52764.
PROQ9NPH6.
SOURCESearch...

Entry information

Entry nameOBP2B_HUMAN
AccessionPrimary (citable) accession number: Q9NPH6
Secondary accession number(s): Q5VSP6, Q9NY51, Q9NY52
Entry history
Integrated into UniProtKB/Swiss-Prot: April 3, 2002
Last sequence update: October 1, 2000
Last modified: July 9, 2014
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 9

Human chromosome 9: entries, gene names and cross-references to MIM