Q9NPH6 (OBP2B_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Odorant-binding protein 2b

Alternative name(s):
Odorant-binding protein IIb
Short name=OBPIIb

Gene names

Name:	OBP2B
ORF Names:	UNQ653/PRO1283

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	170 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Probably binds and transports small hydrophobic volatile molecules.
Subcellular location	Secreted Probable.
Tissue specificity	Strongly expressed in genital sphere organs such as the prostate and mammary glands.
Sequence similarities	Belongs to the calycin superfamily. Lipocalin family.

Ontologies

Keywords
Biological process	Olfaction Sensory transduction Transport
Cellular component	Secreted
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Signal
PTM	Disulfide bond
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	chemosensory behavior Traceable author statement Ref.1. Source: ProtInc sensory perception of smell Non-traceable author statement Ref.1. Source: UniProtKB transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	odorant binding Non-traceable author statement Ref.1. Source: UniProtKB
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform Ba (identifier: Q9NPH6-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform Bb (identifier: Q9NPH6-2)

The sequence of this isoform differs from the canonical sequence as follows:
     93-170: YGGRKLMYLQ...LQTGSCVPEH → CLSAVEMDQI...GPAPHGKACG

Isoform Bg (identifier: Q9NPH6-3)

The sequence of this isoform differs from the canonical sequence as follows:
     25-170: ITGTWYVKAM...LQTGSCVPEH → EGGSVHPEEN...GPAPHGKACG

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 15	15	Potential
	Chain	16 – 170	155	Odorant-binding protein 2b		PRO_0000017938
Amino acid modifications
	Disulfide bond	74 ↔ 166		By similarity
Natural variations
	Alternative sequence	25 – 170	146	ITGTW…CVPEH → EGGSVHPEENPDAEDGGAWQ IQRLWGQEAHIPAGAAQEGP LHLLLQRPAPWGPAPHGKAC G in isoform Bg.		VSP_003139
	Alternative sequence	93 – 170	78	YGGRK…CVPEH → CLSAVEMDQITPALWEALAI DTLRKLRIGTRRPRIRWGQE AHVPAGAAQEGPLHLLLQRP APWGPAPHGKACG in isoform Bb.		VSP_003138
	Natural variant	167	1	V → I. Corresponds to variant rs11244035 [ dbSNP | Ensembl ].		VAR_050177

Sequences

	Sequence		Length	Mass (Da)
	Isoform Ba [UniParc]. Last modified October 1, 2000. Version 1. Checksum: 344FBC37E70739C1	FASTA	170	19,457
	10 20 30 40 50 60 MKTLFLGVTL GLAAALSFTL EEEDITGTWY VKAMVVDKDF PEDRRPRKVS PVKVTALGGG 70 80 90 100 110 120 KLEATFTFMR EDRCIQKKIL MRKTEEPGKY SAYGGRKLMY LQELPRRDHY IFYCKDQHHG 130 140 150 160 170 GLLHMGKLVG RNSDTNREAL EEFKKLVQRK GLSEEDIFTP LQTGSCVPEH
	Isoform Bb [UniParc]. Checksum: 3F867F5F12F1018E	FASTA	165	18,292
	10 20 30 40 50 60 MKTLFLGVTL GLAAALSFTL EEEDITGTWY VKAMVVDKDF PEDRRPRKVS PVKVTALGGG 70 80 90 100 110 120 KLEATFTFMR EDRCIQKKIL MRKTEEPGKY SACLSAVEMD QITPALWEAL AIDTLRKLRI 130 140 150 160 GTRRPRIRWG QEAHVPAGAA QEGPLHLLLQ RPAPWGPAPH GKACG
	Isoform Bg [UniParc]. Checksum: 1F8189B2FFFA0B2E	FASTA	85	8,946
	10 20 30 40 50 60 MKTLFLGVTL GLAAALSFTL EEEDEGGSVH PEENPDAEDG GAWQIQRLWG QEAHIPAGAA 70 80 QEGPLHLLLQ RPAPWGPAPH GKACG

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A novel human odorant-binding protein gene family resulting from genomic duplicons at 9q34: differential expression in the oral and genital spheres." Lacazette E., Gachon A.-M., Pitiot G. Hum. Mol. Genet. 9:289-301(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORMS BA; BB AND BG).
[2]	"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M. Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM BA).
[3]	"DNA sequence and analysis of human chromosome 9." Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L. , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I. Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM BA).

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ251025 Genomic DNA. Translation: CAB71322.1. AJ251026 mRNA. Translation: CAB71323.1. AJ251027 mRNA. Translation: CAB71324.1. AJ251028 mRNA. Translation: CAB71325.1. AY358981 mRNA. Translation: AAQ89340.1. AL732364 Genomic DNA. Translation: CAH73779.1. BC096717 mRNA. Translation: AAH96717.1. BC098125 mRNA. Translation: AAH98125.1. BC098151 mRNA. Translation: AAH98151.1. BC098340 mRNA. Translation: AAH98340.1.
IPI	IPI00005151. IPI00220225. IPI00220227.
RefSeq	NP_055396.1. NM_014581.2.
UniGene	Hs.449629.
3D structure databases
ProteinModelPortal	Q9NPH6.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000361104.
Polymorphism databases
DMDM	20139234.
Proteomic databases
PRIDE	Q9NPH6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000372034; ENSP00000361104; ENSG00000171102. ENST00000473737; ENSP00000434927; ENSG00000171102. ENST00000562137; ENSP00000457426; ENSG00000261059. ENST00000562329; ENSP00000457738; ENSG00000261059.
GeneID	29989.
KEGG	hsa:29989.
UCSC	uc004ccz.3. human.
Organism-specific databases
CTD	29989.
GeneCards	GC09M136080.
HGNC	HGNC:23381. OBP2B.
MIM	604606. gene.
neXtProt	NX_Q9NPH6.
PharmGKB	PA134883553.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG28920.
HOGENOM	HOG000231562.
HOVERGEN	HBG101411.
InParanoid	Q9NPH6.
OMA	GSCVPEH.
OrthoDB	EOG4NP74J.
PhylomeDB	Q9NPH6.
Gene expression databases
ArrayExpress	Q9NPH6.
Bgee	Q9NPH6.
CleanEx	HS_OBP2B.
Genevestigator	Q9NPH6.
GermOnline	ENSG00000171102. Homo sapiens.
Family and domain databases
Gene3D	2.40.128.20. 1 hit.
InterPro	IPR012674. Calycin. IPR011038. Calycin-like. IPR000566. Lipocln_cytosolic_FA-bd_dom. IPR002450. von_Ebner_gland. [Graphical view]
Pfam	PF00061. Lipocalin. 1 hit. [Graphical view]
PRINTS	PR01175. VNEBNERGLAND.
SUPFAM	SSF50814. Calycin. 1 hit.
PROSITE	PS00213. LIPOCALIN. False negative. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	29989.
NextBio	52764.
SOURCE	Search...

Entry information

Entry name

OBP2B_HUMAN

Accession

Primary (citable) accession number: Q9NPH6
Secondary accession number(s): Q5VSP6, Q9NY51, Q9NY52

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 3, 2002
Last sequence update:	October 1, 2000
Last modified:	May 1, 2013
This is version 96 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.