##gff-version 3 Q9NPH5 UniProtKB Chain 1 578 . . . ID=PRO_0000238980;Note=NADPH oxidase 4 Q9NPH5 UniProtKB Topological domain 1 16 . . . Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q9NPH5 UniProtKB Transmembrane 17 37 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q9NPH5 UniProtKB Topological domain 38 62 . . . Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q9NPH5 UniProtKB Transmembrane 63 83 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q9NPH5 UniProtKB Topological domain 84 103 . . . Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q9NPH5 UniProtKB Transmembrane 104 124 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q9NPH5 UniProtKB Topological domain 125 154 . . . Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q9NPH5 UniProtKB Transmembrane 155 175 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q9NPH5 UniProtKB Topological domain 176 188 . . . Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q9NPH5 UniProtKB Transmembrane 189 209 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q9NPH5 UniProtKB Topological domain 210 424 . . . Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q9NPH5 UniProtKB Transmembrane 425 445 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q9NPH5 UniProtKB Topological domain 446 578 . . . Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q9NPH5 UniProtKB Domain 58 303 . . . Note=Ferric oxidoreductase Q9NPH5 UniProtKB Domain 304 419 . . . Note=FAD-binding FR-type;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00716 Q9NPH5 UniProtKB Region 218 273 . . . Note=E-loop%3B essential for H2O2 generating catalytic activity;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21343298;Dbxref=PMID:21343298 Q9NPH5 UniProtKB Region 248 575 . . . Note=Mediates interaction with TLR4;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15356101;Dbxref=PMID:15356101 Q9NPH5 UniProtKB Glycosylation 133 133 . . . Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q9NPH5 UniProtKB Glycosylation 230 230 . . . Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q9NPH5 UniProtKB Alternative sequence 1 74 . . . ID=VSP_019052;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15721269;Dbxref=PMID:15721269 Q9NPH5 UniProtKB Alternative sequence 1 24 . . . ID=VSP_053826;Note=In isoform 8 and isoform 9. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 Q9NPH5 UniProtKB Alternative sequence 52 358 . . . ID=VSP_019053;Note=In isoform 3 and isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15721269;Dbxref=PMID:15721269 Q9NPH5 UniProtKB Alternative sequence 52 54 . . . ID=VSP_019054;Note=In isoform 7. LGL->ELS;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334 Q9NPH5 UniProtKB Alternative sequence 55 578 . . . ID=VSP_019055;Note=In isoform 7. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334 Q9NPH5 UniProtKB Alternative sequence 211 224 . . . ID=VSP_019056;Note=In isoform 5. GLLKYQTNLDTHPP->VQLKPKQHLGFILK;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15721269;Dbxref=PMID:15721269 Q9NPH5 UniProtKB Alternative sequence 225 578 . . . ID=VSP_019057;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15721269;Dbxref=PMID:15721269 Q9NPH5 UniProtKB Alternative sequence 407 446 . . . ID=VSP_019058;Note=In isoform 3%2C isoform 6 and isoform 9. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15210697,ECO:0000303|PubMed:15721269;Dbxref=PMID:14702039,PMID:15210697,PMID:15721269 Q9NPH5 UniProtKB Natural variant 315 315 . . . ID=VAR_047114;Note=M->I;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10869423,ECO:0000269|PubMed:11032835,ECO:0000269|PubMed:11376945,ECO:0000269|PubMed:14702039,ECO:0000269|PubMed:15210697,ECO:0000269|PubMed:15489334,ECO:0000269|PubMed:15721269;Dbxref=dbSNP:rs317139,PMID:10869423,PMID:11032835,PMID:11376945,PMID:14702039,PMID:15210697,PMID:15489334,PMID:15721269 Q9NPH5 UniProtKB Mutagenesis 16 16 . . . Note=50%25 reduction in H2O2 generation%2C without any effect on superoxide generation. H->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21343298;Dbxref=PMID:21343298 Q9NPH5 UniProtKB Mutagenesis 47 47 . . . Note=No effect on H2O2 or superoxide generation. H->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21343298;Dbxref=PMID:21343298 Q9NPH5 UniProtKB Mutagenesis 218 235 . . . Note=Loss of H2O2 generation with predominant generation of superoxide. No effect on localization to the endoplasmic reticulum. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21343298;Dbxref=PMID:21343298 Q9NPH5 UniProtKB Mutagenesis 222 222 . . . Note=Loss of H2O2 generation with predominant generation of superoxide. H->Q;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:21343298,ECO:0000269|PubMed:25062272;Dbxref=PMID:21343298,PMID:25062272 Q9NPH5 UniProtKB Mutagenesis 226 226 . . . Note=Loss of H2O2 generation with predominant generation of superoxide. C->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21343298;Dbxref=PMID:21343298 Q9NPH5 UniProtKB Mutagenesis 246 246 . . . Note=No effect on H2O2 or superoxide generation. H->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21343298;Dbxref=PMID:21343298 Q9NPH5 UniProtKB Mutagenesis 248 248 . . . Note=No effect on H2O2 or superoxide generation. H->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21343298;Dbxref=PMID:21343298 Q9NPH5 UniProtKB Mutagenesis 264 273 . . . Note=Loss of H2O2 generation with predominant generation of superoxide. No effect on localization to the endoplasmic reticulum. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21343298;Dbxref=PMID:21343298 Q9NPH5 UniProtKB Mutagenesis 270 270 . . . Note=Loss of H2O2 generation with predominant generation of superoxide. C->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21343298;Dbxref=PMID:21343298 Q9NPH5 UniProtKB Mutagenesis 304 304 . . . Note=Partial loss of catalytic activity. No effect on CYBA localization. R->RGT;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15927447;Dbxref=PMID:15927447 Q9NPH5 UniProtKB Mutagenesis 575 578 . . . Note=Partial loss of catalytic activity. No effect on CYBA localization. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15927447;Dbxref=PMID:15927447 Q9NPH5 UniProtKB Sequence conflict 286 286 . . . Note=W->C;Ontology_term=ECO:0000305;evidence=ECO:0000305