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Q9NPH3

- IL1AP_HUMAN

UniProt

Q9NPH3 - IL1AP_HUMAN

Protein

Interleukin-1 receptor accessory protein

Gene

IL1RAP

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
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    • History
      Entry version 125 (01 Oct 2014)
      Sequence version 2 (22 Aug 2003)
      Previous versions | rss
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    Functioni

    Coreceptor with IL1R1. Associates with IL1R1 bound to IL1B to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Recruits TOLLIP to the signaling complex. Does not bind to interleukin-1 alone; binding of IL1RN to IL1R1, prevents its association with IL1R1 to form a signaling complex. The cellular response is modulated through a non-signaling association with the membrane IL1R2 decoy receptor. Secreted forms (isoforms 2 and 3) associate with secreted ligand-bound IL1R2 and increase the affinity of secreted IL1R2 for IL1B; this complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors.3 Publications

    GO - Molecular functioni

    1. interleukin-1 receptor activity Source: Ensembl
    2. signal transducer activity Source: ProtInc

    GO - Biological processi

    1. immune response Source: ProtInc
    2. inflammatory response Source: ProtInc
    3. interleukin-2 biosynthetic process Source: Ensembl
    4. protein complex assembly Source: ProtInc

    Keywords - Molecular functioni

    Receptor

    Enzyme and pathway databases

    ReactomeiREACT_22442. Interleukin-1 signaling.
    SignaLinkiQ9NPH3.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Interleukin-1 receptor accessory protein
    Short name:
    IL-1 receptor accessory protein
    Short name:
    IL-1RAcP
    Alternative name(s):
    Interleukin-1 receptor 3
    Short name:
    IL-1R-3
    Short name:
    IL-1R3
    Gene namesi
    Name:IL1RAP
    Synonyms:C3orf13, IL1R3
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 3

    Organism-specific databases

    HGNCiHGNC:5995. IL1RAP.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell
    2. integral component of plasma membrane Source: ProtInc
    3. membrane Source: UniProtKB
    4. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane, Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA29811.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2020Sequence AnalysisAdd
    BLAST
    Chaini21 – 570550Interleukin-1 receptor accessory proteinPRO_0000015450Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi24 ↔ 1221 PublicationPROSITE-ProRule annotation
    Disulfide bondi47 ↔ 1141 PublicationPROSITE-ProRule annotation
    Glycosylationi57 – 571N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi107 – 1071N-linked (GlcNAc...)1 Publication
    Glycosylationi111 – 1111N-linked (GlcNAc...)1 Publication
    Glycosylationi118 – 1181N-linked (GlcNAc...)1 Publication
    Disulfide bondi137 ↔ 1811 PublicationPROSITE-ProRule annotation
    Disulfide bondi160 ↔ 2121 PublicationPROSITE-ProRule annotation
    Glycosylationi196 – 1961N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi209 – 2091N-linked (GlcNAc...)1 Publication
    Disulfide bondi266 ↔ 3321 PublicationPROSITE-ProRule annotation
    Glycosylationi299 – 2991N-linked (GlcNAc...)Sequence Analysis
    Modified residuei557 – 5571Phosphoserine1 Publication

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Phosphoprotein

    Proteomic databases

    MaxQBiQ9NPH3.
    PaxDbiQ9NPH3.
    PRIDEiQ9NPH3.

    PTM databases

    PhosphoSiteiQ9NPH3.

    Expressioni

    Tissue specificityi

    Detected in liver, skin, placenta, thymus and lung.1 Publication

    Inductioni

    Isoform 1 is down-regulated by phorbol ester treatment. Isoform 2 is induced by phorbol ester treatment.2 Publications

    Gene expression databases

    ArrayExpressiQ9NPH3.
    BgeeiQ9NPH3.
    CleanExiHS_IL1RAP.
    GenevestigatoriQ9NPH3.

    Organism-specific databases

    HPAiHPA035293.

    Interactioni

    Subunit structurei

    The interleukin-1 receptor complex is a heterodimer of IL1R1 and IL1RAP. Associates with IL1R2 to form a non-signaling interleukin-1 receptor complex.1 Publication

    Protein-protein interaction databases

    BioGridi109771. 17 interactions.
    DIPiDIP-33487N.
    IntActiQ9NPH3. 10 interactions.
    MINTiMINT-1184198.
    STRINGi9606.ENSP00000072516.

    Structurei

    Secondary structure

    1
    570
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi25 – 295
    Beta strandi31 – 333
    Beta strandi36 – 383
    Beta strandi43 – 464
    Helixi49 – 535
    Beta strandi54 – 563
    Helixi58 – 636
    Beta strandi67 – 7610
    Beta strandi80 – 823
    Helixi88 – 903
    Beta strandi92 – 954
    Beta strandi98 – 1036
    Helixi106 – 1083
    Beta strandi110 – 1178
    Beta strandi122 – 13211
    Beta strandi146 – 1505
    Beta strandi154 – 1596
    Beta strandi174 – 1796
    Beta strandi188 – 1936
    Beta strandi196 – 2016
    Helixi204 – 2063
    Beta strandi208 – 21811
    Beta strandi221 – 23414
    Helixi237 – 2393
    Beta strandi244 – 2463
    Beta strandi250 – 2523
    Beta strandi266 – 2705
    Beta strandi279 – 2857
    Beta strandi300 – 3034
    Beta strandi310 – 3145
    Turni323 – 3275
    Beta strandi331 – 3355
    Beta strandi340 – 3445

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3O4OX-ray3.30B21-350[»]
    4DEPX-ray3.10C/F21-367[»]
    ProteinModelPortaliQ9NPH3.
    SMRiQ9NPH3. Positions 24-346, 403-547.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ9NPH3.

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini21 – 367347ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini389 – 570182CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei368 – 38821HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini21 – 128108Ig-like C2-type 1Add
    BLAST
    Domaini141 – 23090Ig-like C2-type 2Add
    BLAST
    Domaini242 – 348107Ig-like C2-type 3Add
    BLAST
    Domaini403 – 549147TIRPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the interleukin-1 receptor family.Curated
    Contains 1 TIR domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG145997.
    HOGENOMiHOG000092977.
    HOVERGENiHBG104298.
    InParanoidiQ9NPH3.
    KOiK04723.
    OMAiRCDDWGV.
    OrthoDBiEOG7CVPXJ.
    PhylomeDBiQ9NPH3.
    TreeFamiTF325519.

    Family and domain databases

    Gene3Di2.60.40.10. 2 hits.
    3.40.50.10140. 1 hit.
    InterProiIPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003599. Ig_sub.
    IPR015621. IL-1_rcpt_fam.
    IPR004074. IL-1_rcpt_I/II-typ.
    IPR000157. TIR_dom.
    [Graphical view]
    PANTHERiPTHR11890. PTHR11890. 1 hit.
    PfamiPF01582. TIR. 1 hit.
    [Graphical view]
    PRINTSiPR01536. INTRLKN1R12F.
    SMARTiSM00409. IG. 3 hits.
    SM00255. TIR. 1 hit.
    [Graphical view]
    SUPFAMiSSF52200. SSF52200. 1 hit.
    PROSITEiPS50835. IG_LIKE. 2 hits.
    PS50104. TIR. 1 hit.
    [Graphical view]

    Sequences (4)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 4 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9NPH3-1) [UniParc]FASTAAdd to Basket

    Also known as: Membrane-bound IL-1RAcP, mIL-1RAcP

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MTLLWCVVSL YFYGILQSDA SERCDDWGLD TMRQIQVFED EPARIKCPLF    50
    EHFLKFNYST AHSAGLTLIW YWTRQDRDLE EPINFRLPEN RISKEKDVLW 100
    FRPTLLNDTG NYTCMLRNTT YCSKVAFPLE VVQKDSCFNS PMKLPVHKLY 150
    IEYGIQRITC PNVDGYFPSS VKPTITWYMG CYKIQNFNNV IPEGMNLSFL 200
    IALISNNGNY TCVVTYPENG RTFHLTRTLT VKVVGSPKNA VPPVIHSPND 250
    HVVYEKEPGE ELLIPCTVYF SFLMDSRNEV WWTIDGKKPD DITIDVTINE 300
    SISHSRTEDE TRTQILSIKK VTSEDLKRSY VCHARSAKGE VAKAAKVKQK 350
    VPAPRYTVEL ACGFGATVLL VVILIVVYHV YWLEMVLFYR AHFGTDETIL 400
    DGKEYDIYVS YARNAEEEEF VLLTLRGVLE NEFGYKLCIF DRDSLPGGIV 450
    TDETLSFIQK SRRLLVVLSP NYVLQGTQAL LELKAGLENM ASRGNINVIL 500
    VQYKAVKETK VKELKRAKTV LTVIKWKGEK SKYPQGRFWK QLQVAMPVKK 550
    SPRRSSSDEQ GLSYSSLKNV 570
    Length:570
    Mass (Da):65,418
    Last modified:August 22, 2003 - v2
    Checksum:i5F47F8D0ECA98B8A
    GO
    Isoform 2 (identifier: Q9NPH3-2) [UniParc]FASTAAdd to Basket

    Also known as: Soluble IL-1RAcP, sIL-1RAcP

    The sequence of this isoform differs from the canonical sequence as follows:
         351-356: VPAPRY → GNRCGQ
         357-570: Missing.

    Show »
    Length:356
    Mass (Da):41,019
    Checksum:i39B72452C458A1C3
    GO
    Isoform 3 (identifier: Q9NPH3-3) [UniParc]FASTAAdd to Basket

    Also known as: Soluble IL-1RAcP-beta, sIL-1RAcP-beta

    The sequence of this isoform differs from the canonical sequence as follows:
         302-570: ISHSRTEDET...GLSYSSLKNV → ASSKIHSGTG...PILPGSFWNR

    Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

    Show »
    Length:346
    Mass (Da):39,743
    Checksum:i6F13B34E6763E062
    GO
    Isoform 4 (identifier: Q9NPH3-5) [UniParc]FASTAAdd to Basket

    Also known as: AcPb, mIL-1RAcP687

    The sequence of this isoform differs from the canonical sequence as follows:
         449-570: IVTDETLSFI...GLSYSSLKNV → NTVEAVFDFI...LSNNNDFYIL

    Show »
    Length:687
    Mass (Da):78,603
    Checksum:i5489237C18503D4C
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti473 – 4731V → M.
    Corresponds to variant rs34661910 [ dbSNP | Ensembl ].
    VAR_053383

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei302 – 570269ISHSR…SLKNV → ASSKIHSGTGLWFWSHSPAS GDSHCCLPCLLARDGPILPG SFWNR in isoform 3. 1 PublicationVSP_008052Add
    BLAST
    Alternative sequencei351 – 3566VPAPRY → GNRCGQ in isoform 2. 3 PublicationsVSP_008050
    Alternative sequencei357 – 570214Missing in isoform 2. 3 PublicationsVSP_008051Add
    BLAST
    Alternative sequencei449 – 570122IVTDE…SLKNV → NTVEAVFDFIQRSRRMIVVL SPDYVTEKSISMLEFKLGVM CQNSIATKLIVVEYRPLEHP HPGILQLKESVSFVSWKGEK SKHSGSKFWKALRLALPLRS LSASSGWNESCSSQSDISLD HVQRRRSRLKEPPELQSSER AAGSPPAPGTMSKHRGKSSA TCRCCVTYCEGENHLRNKSR AEIHNQPQWETHLCKPVPQE SETQWIQNGTRLEPPAPQIS ALALHHFTDLSNNNDFYIL in isoform 4. 2 PublicationsVSP_041256Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF029213 mRNA. Translation: AAB84059.1.
    AB006537 mRNA. Translation: BAA25421.1.
    AF167343 mRNA. Translation: AAF71687.1.
    AF167340
    , AF167335, AF167336, AF167337, AF167338, AF167339 Genomic DNA. Translation: AAF71688.1.
    AF167342
    , AF167335, AF167336, AF167337, AF167338, AF167339, AF167340, AF167341 Genomic DNA. Translation: AAF71689.1.
    AF538730 mRNA. Translation: AAQ01755.1.
    AF538731 mRNA. Translation: AAQ01756.1.
    AF538732 mRNA. Translation: AAQ01757.1.
    AF538733 mRNA. Translation: AAQ01758.1.
    AF538734 mRNA. Translation: AAQ01759.1.
    AF487335 mRNA. Translation: AAO49451.1.
    EF591790 mRNA. Translation: ABU90811.1.
    FJ998418 mRNA. Translation: ACR82488.1.
    AC008249 Genomic DNA. No translation available.
    AC108747 Genomic DNA. No translation available.
    CH471052 Genomic DNA. Translation: EAW78100.1.
    CH471052 Genomic DNA. Translation: EAW78102.1.
    BC053621 mRNA. Translation: AAH53621.1.
    AF016261 Genomic DNA. Translation: AAC39609.1.
    CCDSiCCDS3298.1. [Q9NPH3-1]
    CCDS46982.1. [Q9NPH3-2]
    CCDS54696.1. [Q9NPH3-5]
    RefSeqiNP_001161400.1. NM_001167928.1. [Q9NPH3-1]
    NP_001161401.1. NM_001167929.1. [Q9NPH3-1]
    NP_001161402.1. NM_001167930.1. [Q9NPH3-2]
    NP_001161403.1. NM_001167931.1. [Q9NPH3-5]
    NP_002173.1. NM_002182.3. [Q9NPH3-1]
    NP_608273.1. NM_134470.3. [Q9NPH3-2]
    XP_005247490.1. XM_005247433.1. [Q9NPH3-5]
    UniGeneiHs.478673.

    Genome annotation databases

    EnsembliENST00000072516; ENSP00000072516; ENSG00000196083. [Q9NPH3-1]
    ENST00000317757; ENSP00000314807; ENSG00000196083. [Q9NPH3-5]
    ENST00000342550; ENSP00000345829; ENSG00000196083. [Q9NPH3-3]
    ENST00000412504; ENSP00000412053; ENSG00000196083. [Q9NPH3-1]
    ENST00000413869; ENSP00000416296; ENSG00000196083. [Q9NPH3-3]
    ENST00000422485; ENSP00000409352; ENSG00000196083. [Q9NPH3-2]
    ENST00000422940; ENSP00000387371; ENSG00000196083. [Q9NPH3-2]
    ENST00000439062; ENSP00000401132; ENSG00000196083. [Q9NPH3-1]
    ENST00000443369; ENSP00000408893; ENSG00000196083. [Q9NPH3-5]
    ENST00000447382; ENSP00000390541; ENSG00000196083. [Q9NPH3-1]
    GeneIDi3556.
    KEGGihsa:3556.
    UCSCiuc003fsk.3. human. [Q9NPH3-2]
    uc003fsm.2. human. [Q9NPH3-1]
    uc003fsq.3. human. [Q9NPH3-5]

    Polymorphism databases

    DMDMi34222652.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF029213 mRNA. Translation: AAB84059.1 .
    AB006537 mRNA. Translation: BAA25421.1 .
    AF167343 mRNA. Translation: AAF71687.1 .
    AF167340
    , AF167335 , AF167336 , AF167337 , AF167338 , AF167339 Genomic DNA. Translation: AAF71688.1 .
    AF167342
    , AF167335 , AF167336 , AF167337 , AF167338 , AF167339 , AF167340 , AF167341 Genomic DNA. Translation: AAF71689.1 .
    AF538730 mRNA. Translation: AAQ01755.1 .
    AF538731 mRNA. Translation: AAQ01756.1 .
    AF538732 mRNA. Translation: AAQ01757.1 .
    AF538733 mRNA. Translation: AAQ01758.1 .
    AF538734 mRNA. Translation: AAQ01759.1 .
    AF487335 mRNA. Translation: AAO49451.1 .
    EF591790 mRNA. Translation: ABU90811.1 .
    FJ998418 mRNA. Translation: ACR82488.1 .
    AC008249 Genomic DNA. No translation available.
    AC108747 Genomic DNA. No translation available.
    CH471052 Genomic DNA. Translation: EAW78100.1 .
    CH471052 Genomic DNA. Translation: EAW78102.1 .
    BC053621 mRNA. Translation: AAH53621.1 .
    AF016261 Genomic DNA. Translation: AAC39609.1 .
    CCDSi CCDS3298.1. [Q9NPH3-1 ]
    CCDS46982.1. [Q9NPH3-2 ]
    CCDS54696.1. [Q9NPH3-5 ]
    RefSeqi NP_001161400.1. NM_001167928.1. [Q9NPH3-1 ]
    NP_001161401.1. NM_001167929.1. [Q9NPH3-1 ]
    NP_001161402.1. NM_001167930.1. [Q9NPH3-2 ]
    NP_001161403.1. NM_001167931.1. [Q9NPH3-5 ]
    NP_002173.1. NM_002182.3. [Q9NPH3-1 ]
    NP_608273.1. NM_134470.3. [Q9NPH3-2 ]
    XP_005247490.1. XM_005247433.1. [Q9NPH3-5 ]
    UniGenei Hs.478673.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3O4O X-ray 3.30 B 21-350 [» ]
    4DEP X-ray 3.10 C/F 21-367 [» ]
    ProteinModelPortali Q9NPH3.
    SMRi Q9NPH3. Positions 24-346, 403-547.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 109771. 17 interactions.
    DIPi DIP-33487N.
    IntActi Q9NPH3. 10 interactions.
    MINTi MINT-1184198.
    STRINGi 9606.ENSP00000072516.

    PTM databases

    PhosphoSitei Q9NPH3.

    Polymorphism databases

    DMDMi 34222652.

    Proteomic databases

    MaxQBi Q9NPH3.
    PaxDbi Q9NPH3.
    PRIDEi Q9NPH3.

    Protocols and materials databases

    DNASUi 3556.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000072516 ; ENSP00000072516 ; ENSG00000196083 . [Q9NPH3-1 ]
    ENST00000317757 ; ENSP00000314807 ; ENSG00000196083 . [Q9NPH3-5 ]
    ENST00000342550 ; ENSP00000345829 ; ENSG00000196083 . [Q9NPH3-3 ]
    ENST00000412504 ; ENSP00000412053 ; ENSG00000196083 . [Q9NPH3-1 ]
    ENST00000413869 ; ENSP00000416296 ; ENSG00000196083 . [Q9NPH3-3 ]
    ENST00000422485 ; ENSP00000409352 ; ENSG00000196083 . [Q9NPH3-2 ]
    ENST00000422940 ; ENSP00000387371 ; ENSG00000196083 . [Q9NPH3-2 ]
    ENST00000439062 ; ENSP00000401132 ; ENSG00000196083 . [Q9NPH3-1 ]
    ENST00000443369 ; ENSP00000408893 ; ENSG00000196083 . [Q9NPH3-5 ]
    ENST00000447382 ; ENSP00000390541 ; ENSG00000196083 . [Q9NPH3-1 ]
    GeneIDi 3556.
    KEGGi hsa:3556.
    UCSCi uc003fsk.3. human. [Q9NPH3-2 ]
    uc003fsm.2. human. [Q9NPH3-1 ]
    uc003fsq.3. human. [Q9NPH3-5 ]

    Organism-specific databases

    CTDi 3556.
    GeneCardsi GC03P190231.
    HGNCi HGNC:5995. IL1RAP.
    HPAi HPA035293.
    MIMi 602626. gene.
    neXtProti NX_Q9NPH3.
    PharmGKBi PA29811.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG145997.
    HOGENOMi HOG000092977.
    HOVERGENi HBG104298.
    InParanoidi Q9NPH3.
    KOi K04723.
    OMAi RCDDWGV.
    OrthoDBi EOG7CVPXJ.
    PhylomeDBi Q9NPH3.
    TreeFami TF325519.

    Enzyme and pathway databases

    Reactomei REACT_22442. Interleukin-1 signaling.
    SignaLinki Q9NPH3.

    Miscellaneous databases

    EvolutionaryTracei Q9NPH3.
    GeneWikii IL1RAP.
    GenomeRNAii 3556.
    NextBioi 13880.
    PROi Q9NPH3.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9NPH3.
    Bgeei Q9NPH3.
    CleanExi HS_IL1RAP.
    Genevestigatori Q9NPH3.

    Family and domain databases

    Gene3Di 2.60.40.10. 2 hits.
    3.40.50.10140. 1 hit.
    InterProi IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003599. Ig_sub.
    IPR015621. IL-1_rcpt_fam.
    IPR004074. IL-1_rcpt_I/II-typ.
    IPR000157. TIR_dom.
    [Graphical view ]
    PANTHERi PTHR11890. PTHR11890. 1 hit.
    Pfami PF01582. TIR. 1 hit.
    [Graphical view ]
    PRINTSi PR01536. INTRLKN1R12F.
    SMARTi SM00409. IG. 3 hits.
    SM00255. TIR. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52200. SSF52200. 1 hit.
    PROSITEi PS50835. IG_LIKE. 2 hits.
    PS50104. TIR. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Recruitment of IRAK to the interleukin 1 receptor complex requires interleukin 1 receptor accessory protein."
      Huang J., Gao X., Li S., Cao Z.
      Proc. Natl. Acad. Sci. U.S.A. 94:12829-12832(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, INTERACTION WITH IL1R1 AND IRAK1.
      Tissue: Placenta.
    2. Saito T., Seki N.
      Submitted (AUG-1997) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Brain.
    3. "IL-1 signaling cascade in liver cells and the involvement of a soluble form of the IL-1 receptor accessory protein."
      Jensen L.E., Muzio M., Mantovani A., Whitehead A.S.
      J. Immunol. 164:5277-5286(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORMS 1 AND 2), FUNCTION, INDUCTION BY PHORBOL ESTERS.
      Tissue: Liver.
    4. "Expression of alternatively spliced interleukin-1 receptor accessory protein mRNAs is differentially regulated during inflammation and apoptosis."
      Jensen L.E., Whitehead A.S.
      Cell. Signal. 15:793-802(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3), INDUCTION BY PHORBOL ESTERS.
      Tissue: Liver.
    5. "A novel alternatively spliced interleukin-1 receptor accessory protein mIL-1RAcP687."
      Lu H.L., Yang C.Y., Chen H.C., Hung C.S., Chiang Y.C., Ting L.P.
      Mol. Immunol. 45:1374-1384(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4).
    6. "A central nervous system-restricted isoform of the interleukin-1 receptor accessory protein modulates neuronal responses to interleukin-1."
      Smith D.E., Lipsky B.P., Russell C., Ketchem R.R., Kirchner J., Hensley K., Huang Y., Friedman W.J., Boissonneault V., Plante M.M., Rivest S., Sims J.E.
      Immunity 30:817-831(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4).
    7. "The DNA sequence, annotation and analysis of human chromosome 3."
      Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
      , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
      Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    8. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    9. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Skin.
    10. "The human gene encoding the interleukin-1 receptor accessory protein (IL1RAP) maps to chromosome 3q28 by fluorescence in situ hybridization and radiation hybrid mapping."
      Dale M., Hammond D.W., Cox A., Nicklin M.J.H.
      Genomics 47:325-326(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 118-179.
    11. "The type II IL-1 receptor interacts with the IL-1 receptor accessory protein: a novel mechanism of regulation of IL-1 responsiveness."
      Lang D., Knop J., Wesche H., Raffetseder U., Kurrle R., Boraschi D., Martin M.U.
      J. Immunol. 161:6871-6877(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH IL1R2.
    12. "Characterization of a cascade of protein interactions initiated at the IL-1 receptor."
      Boch J.A., Yoshida Y., Koyama Y., Wara-Aswapati N., Peng H., Unlu S., Auron P.E.
      Biochem. Biophys. Res. Commun. 303:525-531(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH IRAK2.
    13. "The soluble form of IL-1 receptor accessory protein enhances the ability of soluble type II IL-1 receptor to inhibit IL-1 action."
      Smith D.E., Hanna R., Friend D., Moore H., Chen H., Farese A.M., MacVittie T.J., Virca G.D., Sims J.E.
      Immunity 18:87-96(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION (SECRETED FORMS), TISSUE SPECIFICITY.
    14. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    15. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    16. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-557, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    17. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    18. "Structural insights into the assembly and activation of IL-1beta with its receptors."
      Wang D., Zhang S., Li L., Liu X., Mei K., Wang X.
      Nat. Immunol. 11:905-911(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (3.3 ANGSTROMS) OF 21-350 IN COMPLEX WITH IL1R2 AND IL1B, SUBUNIT, DISULFIDE BONDS, GLYCOSYLATION AT ASN-107; ASN-111; ASN-118 AND ASN-209.

    Entry informationi

    Entry nameiIL1AP_HUMAN
    AccessioniPrimary (citable) accession number: Q9NPH3
    Secondary accession number(s): B1NLD0
    , D3DNW0, O14915, Q86WJ7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 22, 2003
    Last sequence update: August 22, 2003
    Last modified: October 1, 2014
    This is version 125 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 3
      Human chromosome 3: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3