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Protein

Lysophosphatidic acid phosphatase type 6

Gene

ACP6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Hydrolyzes lysophosphatidic acid (LPA) containing a medium length fatty acid chain to the corresponding monoacylglycerol. Has highest activity with lysophosphatidic acid containing myristate (C14:0), monounsaturated oleate (C18:1) or palmitate (C16:0), and lower activity with C18:0 and C6:0 lysophosphatidic acid.2 Publications

Catalytic activityi

A phosphate monoester + H2O = an alcohol + phosphate.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei59Nucleophile1 Publication1
Active sitei335Proton donor1 Publication1

GO - Molecular functioni

GO - Biological processi

  • lysobisphosphatidic acid metabolic process Source: UniProtKB
  • phospholipid metabolic process Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Lipid metabolism, Phospholipid metabolism

Enzyme and pathway databases

BioCyciZFISH:HS08744-MONOMER.
ReactomeiR-HSA-1483166. Synthesis of PA.

Chemistry databases

SwissLipidsiSLP:000001294.

Names & Taxonomyi

Protein namesi
Recommended name:
Lysophosphatidic acid phosphatase type 6 (EC:3.1.3.2)
Alternative name(s):
Acid phosphatase 6, lysophosphatidic
Acid phosphatase-like protein 1
PACPL1
Gene namesi
Name:ACP6
Synonyms:ACPL1, LPAP
ORF Names:UNQ205/PRO231
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:29609. ACP6.

Subcellular locationi

  • Mitochondrion 1 Publication

GO - Cellular componenti

  • cytoplasm Source: MGI
  • mitochondrion Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi58R → A: Abolishes enzyme activity. 1 Publication1
Mutagenesisi59H → A: Abolishes enzyme activity. 2 Publications1
Mutagenesisi62R → A: Abolishes enzyme activity. 1 Publication1
Mutagenesisi106Y → F: Decreases enzyme activity. 1 Publication1
Mutagenesisi110Y → F: Decreases enzyme activity. 1
Mutagenesisi168R → A: Abolishes enzyme activity. 1 Publication1
Mutagenesisi257A → F or L: Decreases enzyme activity by interfering with water access to the active site cavity. 1 Publication1
Mutagenesisi257A → W: Abolishes enzyme activity by interfering with water access to the active site cavity. 1 Publication1
Mutagenesisi285S → W: Decreases activity toward substrates with medium and long aliphatic chains, but not toward substrates with short aliphatic chains. 1 Publication1
Mutagenesisi289L → W: Decreases activity toward substrates with medium and long aliphatic chains, but not toward substrates with short aliphatic chains. 1 Publication1
Mutagenesisi334H → A: Abolishes enzyme activity. 1 Publication1
Mutagenesisi335D → A: Abolishes enzyme activity. 1 Publication1

Organism-specific databases

DisGeNETi51205.
OpenTargetsiENSG00000162836.
PharmGKBiPA134930830.

Polymorphism and mutation databases

DMDMi317373268.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 32Mitochondrion1 PublicationAdd BLAST32
ChainiPRO_000002396533 – 428Lysophosphatidic acid phosphatase type 6Add BLAST396

Proteomic databases

EPDiQ9NPH0.
MaxQBiQ9NPH0.
PaxDbiQ9NPH0.
PeptideAtlasiQ9NPH0.
PRIDEiQ9NPH0.

PTM databases

DEPODiQ9NPH0.
iPTMnetiQ9NPH0.
PhosphoSitePlusiQ9NPH0.

Expressioni

Tissue specificityi

Highly expressed in kidney, heart, small intestine, muscle, liver, prostate, testis, ovary and weakly expressed in thymus and colon.2 Publications

Inductioni

Induced with the differentiation from myoblast to myotube.1 Publication

Gene expression databases

BgeeiENSG00000162836.
CleanExiHS_ACP6.
ExpressionAtlasiQ9NPH0. baseline and differential.

Organism-specific databases

HPAiHPA028560.

Interactioni

Subunit structurei

Monomer.1 Publication

Protein-protein interaction databases

BioGridi119378. 21 interactors.
IntActiQ9NPH0. 2 interactors.
MINTiMINT-1387194.
STRINGi9606.ENSP00000358241.

Structurei

Secondary structure

1428
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi45 – 47Combined sources3
Beta strandi48 – 58Combined sources11
Beta strandi69 – 71Combined sources3
Helixi78 – 81Combined sources4
Helixi85 – 87Combined sources3
Beta strandi92 – 100Combined sources9
Helixi105 – 111Combined sources7
Turni116 – 118Combined sources3
Helixi126 – 143Combined sources18
Turni144 – 146Combined sources3
Beta strandi152 – 154Combined sources3
Turni156 – 158Combined sources3
Beta strandi159 – 163Combined sources5
Helixi167 – 181Combined sources15
Beta strandi185 – 187Combined sources3
Beta strandi190 – 193Combined sources4
Turni196 – 198Combined sources3
Turni205 – 207Combined sources3
Helixi209 – 221Combined sources13
Helixi222 – 224Combined sources3
Helixi228 – 238Combined sources11
Helixi249 – 261Combined sources13
Helixi268 – 272Combined sources5
Helixi274 – 288Combined sources15
Helixi294 – 314Combined sources21
Beta strandi318 – 320Combined sources3
Turni322 – 324Combined sources3
Beta strandi327 – 333Combined sources7
Helixi335 – 344Combined sources10
Beta strandi358 – 366Combined sources9
Turni367 – 369Combined sources3
Beta strandi372 – 378Combined sources7
Beta strandi381 – 383Combined sources3
Beta strandi389 – 394Combined sources6
Helixi395 – 402Combined sources8
Turni403 – 405Combined sources3
Helixi409 – 416Combined sources8

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4JOBX-ray2.17A33-428[»]
4JOCX-ray2.21A33-428[»]
4JODX-ray2.21A33-428[»]
ProteinModelPortaliQ9NPH0.
SMRiQ9NPH0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni58 – 168Substrate bindingBy similarityAdd BLAST111

Sequence similaritiesi

Belongs to the histidine acid phosphatase family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG3720. Eukaryota.
ENOG410ZVBQ. LUCA.
GeneTreeiENSGT00530000062956.
HOGENOMiHOG000290692.
HOVERGENiHBG079458.
InParanoidiQ9NPH0.
KOiK14395.
PhylomeDBiQ9NPH0.
TreeFamiTF318821.

Family and domain databases

CDDicd07061. HP_HAP_like. 1 hit.
Gene3Di3.40.50.1240. 2 hits.
InterProiIPR033379. Acid_Pase_AS.
IPR000560. His_Pase_clade-2.
IPR029033. His_PPase_superfam.
[Graphical view]
PfamiPF00328. His_Phos_2. 1 hit.
[Graphical view]
SUPFAMiSSF53254. SSF53254. 2 hits.
PROSITEiPS00616. HIS_ACID_PHOSPHAT_1. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9NPH0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MITGVFSMRL WTPVGVLTSL AYCLHQRRVA LAELQEADGQ CPVDRSLLKL
60 70 80 90 100
KMVQVVFRHG ARSPLKPLPL EEQVEWNPQL LEVPPQTQFD YTVTNLAGGP
110 120 130 140 150
KPYSPYDSQY HETTLKGGMF AGQLTKVGMQ QMFALGERLR KNYVEDIPFL
160 170 180 190 200
SPTFNPQEVF IRSTNIFRNL ESTRCLLAGL FQCQKEGPII IHTDEADSEV
210 220 230 240 250
LYPNYQSCWS LRQRTRGRRQ TASLQPGISE DLKKVKDRMG IDSSDKVDFF
260 270 280 290 300
ILLDNVAAEQ AHNLPSCPML KRFARMIEQR AVDTSLYILP KEDRESLQMA
310 320 330 340 350
VGPFLHILES NLLKAVDSAT APDKIRKLYL YAAHDVTFIP LLMTLGIFDH
360 370 380 390 400
KWPPFAVDLT MELYQHLESK EWFVQLYYHG KEQVPRGCPD GLCPLDMFLN
410 420
AMSVYTLSPE KYHALCSQTQ VMEVGNEE
Length:428
Mass (Da):48,854
Last modified:January 11, 2011 - v2
Checksum:i37A09CFD1BB45BFA
GO
Isoform 2 (identifier: Q9NPH0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     261-271: AHNLPSCPMLK → EKMGSCRFHGS
     272-428: Missing.

Note: No experimental confirmation available.
Show »
Length:271
Mass (Da):30,790
Checksum:iFF6FF0AFF8D01144
GO

Sequence cautioni

The sequence BAA89311 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAD92485 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti428E → D in CAG33382 (Ref. 8) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_022678316V → M.6 PublicationsCorresponds to variant rs6593795dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_014121261 – 271AHNLPSCPMLK → EKMGSCRFHGS in isoform 2. 1 PublicationAdd BLAST11
Alternative sequenceiVSP_014122272 – 428Missing in isoform 2. 1 PublicationAdd BLAST157

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB031478 mRNA. Translation: BAA89311.1. Different initiation.
AB030039 mRNA. Translation: BAA94309.2.
AY358552 mRNA. Translation: AAQ88916.1.
AK000657 mRNA. Translation: BAA91310.1.
AB209248 mRNA. Translation: BAD92485.1. Different initiation.
AL359207 Genomic DNA. Translation: CAI15199.1.
BC009965 mRNA. Translation: AAH09965.1.
BC034686 mRNA. Translation: AAH34686.1.
CR457101 mRNA. Translation: CAG33382.1.
CCDSiCCDS928.1. [Q9NPH0-1]
RefSeqiNP_057445.4. NM_016361.4.
UniGeneiHs.562154.

Genome annotation databases

EnsembliENST00000487562; ENSP00000481777; ENSG00000162836. [Q9NPH0-2]
GeneIDi51205.
KEGGihsa:51205.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB031478 mRNA. Translation: BAA89311.1. Different initiation.
AB030039 mRNA. Translation: BAA94309.2.
AY358552 mRNA. Translation: AAQ88916.1.
AK000657 mRNA. Translation: BAA91310.1.
AB209248 mRNA. Translation: BAD92485.1. Different initiation.
AL359207 Genomic DNA. Translation: CAI15199.1.
BC009965 mRNA. Translation: AAH09965.1.
BC034686 mRNA. Translation: AAH34686.1.
CR457101 mRNA. Translation: CAG33382.1.
CCDSiCCDS928.1. [Q9NPH0-1]
RefSeqiNP_057445.4. NM_016361.4.
UniGeneiHs.562154.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4JOBX-ray2.17A33-428[»]
4JOCX-ray2.21A33-428[»]
4JODX-ray2.21A33-428[»]
ProteinModelPortaliQ9NPH0.
SMRiQ9NPH0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119378. 21 interactors.
IntActiQ9NPH0. 2 interactors.
MINTiMINT-1387194.
STRINGi9606.ENSP00000358241.

Chemistry databases

SwissLipidsiSLP:000001294.

PTM databases

DEPODiQ9NPH0.
iPTMnetiQ9NPH0.
PhosphoSitePlusiQ9NPH0.

Polymorphism and mutation databases

DMDMi317373268.

Proteomic databases

EPDiQ9NPH0.
MaxQBiQ9NPH0.
PaxDbiQ9NPH0.
PeptideAtlasiQ9NPH0.
PRIDEiQ9NPH0.

Protocols and materials databases

DNASUi51205.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000487562; ENSP00000481777; ENSG00000162836. [Q9NPH0-2]
GeneIDi51205.
KEGGihsa:51205.

Organism-specific databases

CTDi51205.
DisGeNETi51205.
GeneCardsiACP6.
H-InvDBHIX0000989.
HGNCiHGNC:29609. ACP6.
HPAiHPA028560.
MIMi611471. gene.
neXtProtiNX_Q9NPH0.
OpenTargetsiENSG00000162836.
PharmGKBiPA134930830.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3720. Eukaryota.
ENOG410ZVBQ. LUCA.
GeneTreeiENSGT00530000062956.
HOGENOMiHOG000290692.
HOVERGENiHBG079458.
InParanoidiQ9NPH0.
KOiK14395.
PhylomeDBiQ9NPH0.
TreeFamiTF318821.

Enzyme and pathway databases

BioCyciZFISH:HS08744-MONOMER.
ReactomeiR-HSA-1483166. Synthesis of PA.

Miscellaneous databases

ChiTaRSiACP6. human.
GeneWikiiACP6.
GenomeRNAii51205.
PROiQ9NPH0.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000162836.
CleanExiHS_ACP6.
ExpressionAtlasiQ9NPH0. baseline and differential.

Family and domain databases

CDDicd07061. HP_HAP_like. 1 hit.
Gene3Di3.40.50.1240. 2 hits.
InterProiIPR033379. Acid_Pase_AS.
IPR000560. His_Pase_clade-2.
IPR029033. His_PPase_superfam.
[Graphical view]
PfamiPF00328. His_Phos_2. 1 hit.
[Graphical view]
SUPFAMiSSF53254. SSF53254. 2 hits.
PROSITEiPS00616. HIS_ACID_PHOSPHAT_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPPA6_HUMAN
AccessioniPrimary (citable) accession number: Q9NPH0
Secondary accession number(s): Q59G61
, Q5T490, Q6IAQ3, Q7LG81, Q9UIG6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 21, 2005
Last sequence update: January 11, 2011
Last modified: November 30, 2016
This is version 132 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-8 is the initiator.Curated
Was originally reported to be located in the mitochondrion, but the evidence seems to be weak and contradictory with the presence of a cleaved signal sequence.1 Publication

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.