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Protein

Probable palmitoyltransferase ZDHHC4

Gene

ZDHHC4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

Palmitoyl-CoA + [protein]-L-cysteine = [protein]-S-palmitoyl-L-cysteine + CoA.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei179S-palmitoyl cysteine intermediateBy similarity1

GO - Molecular functioni

Keywordsi

Molecular functionAcyltransferase, Transferase

Enzyme and pathway databases

BRENDAi2.3.1.225 2681

Names & Taxonomyi

Protein namesi
Recommended name:
Probable palmitoyltransferase ZDHHC4 (EC:2.3.1.225)
Alternative name(s):
Zinc finger DHHC domain-containing protein 4
Short name:
DHHC-4
Zinc finger protein 374
Gene namesi
Name:ZDHHC4
Synonyms:ZNF374
ORF Names:DC1, UNQ5787/PRO19576
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000136247.14
HGNCiHGNC:18471 ZDHHC4
neXtProtiNX_Q9NPG8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei3 – 23HelicalSequence analysisAdd BLAST21
Transmembranei68 – 88HelicalSequence analysisAdd BLAST21
Transmembranei100 – 120HelicalSequence analysisAdd BLAST21
Transmembranei193 – 213HelicalSequence analysisAdd BLAST21
Transmembranei256 – 276HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi340R → A: Does not affect localization to the endoplasmic reticulum. 1 Publication1
Mutagenesisi341K → A: Does not affect localization to the endoplasmic reticulum. 1 Publication1
Mutagenesisi342K → A: Impaired localization to the endoplasmic reticulum. 1 Publication1

Organism-specific databases

OpenTargetsiENSG00000136247
PharmGKBiPA38337

Polymorphism and mutation databases

BioMutaiZDHHC4
DMDMi28202108

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002128651 – 344Probable palmitoyltransferase ZDHHC4Add BLAST344

Keywords - PTMi

Lipoprotein, Palmitate

Proteomic databases

EPDiQ9NPG8
MaxQBiQ9NPG8
PaxDbiQ9NPG8
PeptideAtlasiQ9NPG8
PRIDEiQ9NPG8
ProteomicsDBi81994

PTM databases

iPTMnetiQ9NPG8
PhosphoSitePlusiQ9NPG8

Expressioni

Gene expression databases

BgeeiENSG00000136247
CleanExiHS_ZDHHC4
ExpressionAtlasiQ9NPG8 baseline and differential
GenevisibleiQ9NPG8 HS

Organism-specific databases

HPAiHPA032124
HPA064358

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000337475

Structurei

3D structure databases

ProteinModelPortaliQ9NPG8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini149 – 199DHHCPROSITE-ProRule annotationAdd BLAST51

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi341 – 344Di-lysine motif1 Publication4

Domaini

The C-terminal di-lysine motif confers endoplasmic reticulum localization.1 Publication
The DHHC domain is required for palmitoyltransferase activity.By similarity

Sequence similaritiesi

Belongs to the DHHC palmitoyltransferase family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1312 Eukaryota
COG5273 LUCA
GeneTreeiENSGT00920000149163
HOGENOMiHOG000253024
HOVERGENiHBG054775
InParanoidiQ9NPG8
KOiK20003
OMAiHGLWSNL
OrthoDBiEOG091G0BJJ
PhylomeDBiQ9NPG8
TreeFamiTF330931

Family and domain databases

InterProiView protein in InterPro
IPR001594 Palmitoyltrfase_DHHC
PfamiView protein in Pfam
PF01529 DHHC, 1 hit
PROSITEiView protein in PROSITE
PS50216 DHHC, 1 hit

Sequencei

Sequence statusi: Complete.

Q9NPG8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDFLVLFLFY LASVLMGLVL ICVCSKTHSL KGLARGGAQI FSCIIPECLQ
60 70 80 90 100
RAVHGLLHYL FHTRNHTFIV LHLVLQGMVY TEYTWEVFGY CQELELSLHY
110 120 130 140 150
LLLPYLLLGV NLFFFTLTCG TNPGIITKAN ELLFLHVYEF DEVMFPKNVR
160 170 180 190 200
CSTCDLRKPA RSKHCSVCNW CVHRFDHHCV WVNNCIGAWN IRYFLIYVLT
210 220 230 240 250
LTASAATVAI VSTTFLVHLV VMSDLYQETY IDDLGHLHVM DTVFLIQYLF
260 270 280 290 300
LTFPRIVFML GFVVVLSFLL GGYLLFVLYL AATNQTTNEW YRGDWAWCQR
310 320 330 340
CPLVAWPPSA EPQVHRNIHS HGLRSNLQEI FLPAFPCHER KKQE
Length:344
Mass (Da):39,787
Last modified:October 1, 2000 - v1
Checksum:i3D2CF22B14036908
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti33L → P in BAD97252 (Ref. 6) Curated1
Sequence conflicti244F → I in CAB66609 (PubMed:11230166).Curated1
Sequence conflicti244F → I in CAG38542 (Ref. 4) Curated1
Sequence conflicti276F → S in CAB66609 (PubMed:11230166).Curated1
Sequence conflicti276F → S in CAG38542 (Ref. 4) Curated1
Sequence conflicti294D → V in CAB66609 (PubMed:11230166).Curated1
Sequence conflicti294D → V in CAG38542 (Ref. 4) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02383253V → M1 PublicationCorresponds to variant dbSNP:rs11559146Ensembl.1
Natural variantiVAR_036260104P → S in a breast cancer sample; somatic mutation. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF201931 mRNA Translation: AAF86867.1
AL136674 mRNA Translation: CAB66609.1
AY359090 mRNA Translation: AAQ89448.1
CR533511 mRNA Translation: CAG38542.1
AK001341 mRNA Translation: BAA91636.1
AK223532 mRNA Translation: BAD97252.1
AC079742 Genomic DNA No translation available.
CH236963 Genomic DNA Translation: EAL23725.1
CH878731 Genomic DNA Translation: EAW55023.1
BC001239 mRNA Translation: AAH01239.1
CCDSiCCDS5352.1
RefSeqiNP_001127859.1, NM_001134387.1
NP_001127860.1, NM_001134388.1
NP_001127861.1, NM_001134389.1
NP_060576.1, NM_018106.3
XP_005249850.1, XM_005249793.2
XP_005249851.1, XM_005249794.3
XP_005249852.1, XM_005249795.2
XP_005249853.1, XM_005249796.3
UniGeneiHs.5268

Genome annotation databases

EnsembliENST00000335965; ENSP00000337475; ENSG00000136247
ENST00000396706; ENSP00000379934; ENSG00000136247
ENST00000396707; ENSP00000379935; ENSG00000136247
ENST00000396709; ENSP00000379937; ENSG00000136247
ENST00000396713; ENSP00000379941; ENSG00000136247
ENST00000405731; ENSP00000385027; ENSG00000136247
GeneIDi55146
KEGGihsa:55146
UCSCiuc003sqh.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiZDHC4_HUMAN
AccessioniPrimary (citable) accession number: Q9NPG8
Secondary accession number(s): A4D2N9
, Q53EV7, Q6FIB5, Q9H0R9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 2003
Last sequence update: October 1, 2000
Last modified: June 20, 2018
This is version 137 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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