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Protein

Probable palmitoyltransferase ZDHHC4

Gene

ZDHHC4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Palmitoyl-CoA + [protein]-L-cysteine = [protein]-S-palmitoyl-L-cysteine + CoA.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei179S-palmitoyl cysteine intermediateBy similarity1

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Enzyme and pathway databases

BioCyciZFISH:ENSG00000136247-MONOMER.
BRENDAi2.3.1.225. 2681.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable palmitoyltransferase ZDHHC4 (EC:2.3.1.225)
Alternative name(s):
Zinc finger DHHC domain-containing protein 4
Short name:
DHHC-4
Zinc finger protein 374
Gene namesi
Name:ZDHHC4
Synonyms:ZNF374
ORF Names:DC1, UNQ5787/PRO19576
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:18471. ZDHHC4.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei3 – 23HelicalSequence analysisAdd BLAST21
Transmembranei68 – 88HelicalSequence analysisAdd BLAST21
Transmembranei100 – 120HelicalSequence analysisAdd BLAST21
Transmembranei193 – 213HelicalSequence analysisAdd BLAST21
Transmembranei256 – 276HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

  • Golgi apparatus Source: UniProtKB
  • integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000136247.
PharmGKBiPA38337.

Polymorphism and mutation databases

BioMutaiZDHHC4.
DMDMi28202108.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002128651 – 344Probable palmitoyltransferase ZDHHC4Add BLAST344

Keywords - PTMi

Lipoprotein, Palmitate

Proteomic databases

EPDiQ9NPG8.
MaxQBiQ9NPG8.
PaxDbiQ9NPG8.
PeptideAtlasiQ9NPG8.
PRIDEiQ9NPG8.

PTM databases

iPTMnetiQ9NPG8.
PhosphoSitePlusiQ9NPG8.

Expressioni

Gene expression databases

BgeeiENSG00000136247.
CleanExiHS_ZDHHC4.
ExpressionAtlasiQ9NPG8. baseline and differential.
GenevisibleiQ9NPG8. HS.

Organism-specific databases

HPAiHPA032124.
HPA064358.

Interactioni

Protein-protein interaction databases

MINTiMINT-1208911.
STRINGi9606.ENSP00000337475.

Structurei

3D structure databases

ProteinModelPortaliQ9NPG8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini149 – 199DHHCPROSITE-ProRule annotationAdd BLAST51

Domaini

The DHHC domain is required for palmitoyltransferase activity.By similarity

Sequence similaritiesi

Belongs to the DHHC palmitoyltransferase family.Curated
Contains 1 DHHC domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1312. Eukaryota.
COG5273. LUCA.
GeneTreeiENSGT00860000133803.
HOGENOMiHOG000253024.
HOVERGENiHBG054775.
InParanoidiQ9NPG8.
KOiK20003.
OMAiGAWNIRY.
OrthoDBiEOG091G0BJJ.
PhylomeDBiQ9NPG8.
TreeFamiTF330931.

Family and domain databases

InterProiIPR001594. Znf_DHHC_palmitoyltrfase.
[Graphical view]
PfamiPF01529. zf-DHHC. 1 hit.
[Graphical view]
PROSITEiPS50216. DHHC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9NPG8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDFLVLFLFY LASVLMGLVL ICVCSKTHSL KGLARGGAQI FSCIIPECLQ
60 70 80 90 100
RAVHGLLHYL FHTRNHTFIV LHLVLQGMVY TEYTWEVFGY CQELELSLHY
110 120 130 140 150
LLLPYLLLGV NLFFFTLTCG TNPGIITKAN ELLFLHVYEF DEVMFPKNVR
160 170 180 190 200
CSTCDLRKPA RSKHCSVCNW CVHRFDHHCV WVNNCIGAWN IRYFLIYVLT
210 220 230 240 250
LTASAATVAI VSTTFLVHLV VMSDLYQETY IDDLGHLHVM DTVFLIQYLF
260 270 280 290 300
LTFPRIVFML GFVVVLSFLL GGYLLFVLYL AATNQTTNEW YRGDWAWCQR
310 320 330 340
CPLVAWPPSA EPQVHRNIHS HGLRSNLQEI FLPAFPCHER KKQE
Length:344
Mass (Da):39,787
Last modified:October 1, 2000 - v1
Checksum:i3D2CF22B14036908
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti33L → P in BAD97252 (Ref. 6) Curated1
Sequence conflicti244F → I in CAB66609 (PubMed:11230166).Curated1
Sequence conflicti244F → I in CAG38542 (Ref. 4) Curated1
Sequence conflicti276F → S in CAB66609 (PubMed:11230166).Curated1
Sequence conflicti276F → S in CAG38542 (Ref. 4) Curated1
Sequence conflicti294D → V in CAB66609 (PubMed:11230166).Curated1
Sequence conflicti294D → V in CAG38542 (Ref. 4) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02383253V → M.1 PublicationCorresponds to variant rs11559146dbSNPEnsembl.1
Natural variantiVAR_036260104P → S in a breast cancer sample; somatic mutation. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF201931 mRNA. Translation: AAF86867.1.
AL136674 mRNA. Translation: CAB66609.1.
AY359090 mRNA. Translation: AAQ89448.1.
CR533511 mRNA. Translation: CAG38542.1.
AK001341 mRNA. Translation: BAA91636.1.
AK223532 mRNA. Translation: BAD97252.1.
AC079742 Genomic DNA. No translation available.
CH236963 Genomic DNA. Translation: EAL23725.1.
CH878731 Genomic DNA. Translation: EAW55023.1.
BC001239 mRNA. Translation: AAH01239.1.
CCDSiCCDS5352.1.
RefSeqiNP_001127859.1. NM_001134387.1.
NP_001127860.1. NM_001134388.1.
NP_001127861.1. NM_001134389.1.
NP_060576.1. NM_018106.3.
XP_005249850.1. XM_005249793.2.
XP_005249851.1. XM_005249794.3.
XP_005249852.1. XM_005249795.2.
XP_005249853.1. XM_005249796.3.
UniGeneiHs.5268.

Genome annotation databases

EnsembliENST00000335965; ENSP00000337475; ENSG00000136247.
ENST00000396706; ENSP00000379934; ENSG00000136247.
ENST00000396707; ENSP00000379935; ENSG00000136247.
ENST00000396709; ENSP00000379937; ENSG00000136247.
ENST00000396713; ENSP00000379941; ENSG00000136247.
ENST00000405731; ENSP00000385027; ENSG00000136247.
GeneIDi55146.
KEGGihsa:55146.
UCSCiuc003sqh.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF201931 mRNA. Translation: AAF86867.1.
AL136674 mRNA. Translation: CAB66609.1.
AY359090 mRNA. Translation: AAQ89448.1.
CR533511 mRNA. Translation: CAG38542.1.
AK001341 mRNA. Translation: BAA91636.1.
AK223532 mRNA. Translation: BAD97252.1.
AC079742 Genomic DNA. No translation available.
CH236963 Genomic DNA. Translation: EAL23725.1.
CH878731 Genomic DNA. Translation: EAW55023.1.
BC001239 mRNA. Translation: AAH01239.1.
CCDSiCCDS5352.1.
RefSeqiNP_001127859.1. NM_001134387.1.
NP_001127860.1. NM_001134388.1.
NP_001127861.1. NM_001134389.1.
NP_060576.1. NM_018106.3.
XP_005249850.1. XM_005249793.2.
XP_005249851.1. XM_005249794.3.
XP_005249852.1. XM_005249795.2.
XP_005249853.1. XM_005249796.3.
UniGeneiHs.5268.

3D structure databases

ProteinModelPortaliQ9NPG8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-1208911.
STRINGi9606.ENSP00000337475.

PTM databases

iPTMnetiQ9NPG8.
PhosphoSitePlusiQ9NPG8.

Polymorphism and mutation databases

BioMutaiZDHHC4.
DMDMi28202108.

Proteomic databases

EPDiQ9NPG8.
MaxQBiQ9NPG8.
PaxDbiQ9NPG8.
PeptideAtlasiQ9NPG8.
PRIDEiQ9NPG8.

Protocols and materials databases

DNASUi55146.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000335965; ENSP00000337475; ENSG00000136247.
ENST00000396706; ENSP00000379934; ENSG00000136247.
ENST00000396707; ENSP00000379935; ENSG00000136247.
ENST00000396709; ENSP00000379937; ENSG00000136247.
ENST00000396713; ENSP00000379941; ENSG00000136247.
ENST00000405731; ENSP00000385027; ENSG00000136247.
GeneIDi55146.
KEGGihsa:55146.
UCSCiuc003sqh.4. human.

Organism-specific databases

CTDi55146.
GeneCardsiZDHHC4.
HGNCiHGNC:18471. ZDHHC4.
HPAiHPA032124.
HPA064358.
neXtProtiNX_Q9NPG8.
OpenTargetsiENSG00000136247.
PharmGKBiPA38337.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1312. Eukaryota.
COG5273. LUCA.
GeneTreeiENSGT00860000133803.
HOGENOMiHOG000253024.
HOVERGENiHBG054775.
InParanoidiQ9NPG8.
KOiK20003.
OMAiGAWNIRY.
OrthoDBiEOG091G0BJJ.
PhylomeDBiQ9NPG8.
TreeFamiTF330931.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000136247-MONOMER.
BRENDAi2.3.1.225. 2681.

Miscellaneous databases

ChiTaRSiZDHHC4. human.
GeneWikiiZDHHC4.
GenomeRNAii55146.
PROiQ9NPG8.

Gene expression databases

BgeeiENSG00000136247.
CleanExiHS_ZDHHC4.
ExpressionAtlasiQ9NPG8. baseline and differential.
GenevisibleiQ9NPG8. HS.

Family and domain databases

InterProiIPR001594. Znf_DHHC_palmitoyltrfase.
[Graphical view]
PfamiPF01529. zf-DHHC. 1 hit.
[Graphical view]
PROSITEiPS50216. DHHC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZDHC4_HUMAN
AccessioniPrimary (citable) accession number: Q9NPG8
Secondary accession number(s): A4D2N9
, Q53EV7, Q6FIB5, Q9H0R9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 2003
Last sequence update: October 1, 2000
Last modified: November 30, 2016
This is version 127 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.