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Protein

Probable palmitoyltransferase ZDHHC4

Gene

ZDHHC4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Palmitoyl-CoA + [protein]-L-cysteine = [protein]-S-palmitoyl-L-cysteine + CoA.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei179 – 1791S-palmitoyl cysteine intermediateBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri149 – 19951DHHC-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BRENDAi2.3.1.225. 2681.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable palmitoyltransferase ZDHHC4 (EC:2.3.1.225)
Alternative name(s):
Zinc finger DHHC domain-containing protein 4
Short name:
DHHC-4
Zinc finger protein 374
Gene namesi
Name:ZDHHC4
Synonyms:ZNF374
ORF Names:DC1, UNQ5787/PRO19576
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:18471. ZDHHC4.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei3 – 2321HelicalSequence analysisAdd
BLAST
Transmembranei68 – 8821HelicalSequence analysisAdd
BLAST
Transmembranei100 – 12021HelicalSequence analysisAdd
BLAST
Transmembranei193 – 21321HelicalSequence analysisAdd
BLAST
Transmembranei256 – 27621HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

  • Golgi apparatus Source: UniProtKB
  • integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA38337.

Polymorphism and mutation databases

BioMutaiZDHHC4.
DMDMi28202108.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 344344Probable palmitoyltransferase ZDHHC4PRO_0000212865Add
BLAST

Proteomic databases

MaxQBiQ9NPG8.
PaxDbiQ9NPG8.
PRIDEiQ9NPG8.

PTM databases

iPTMnetiQ9NPG8.
PhosphoSiteiQ9NPG8.

Expressioni

Gene expression databases

BgeeiQ9NPG8.
CleanExiHS_ZDHHC4.
ExpressionAtlasiQ9NPG8. baseline and differential.
GenevisibleiQ9NPG8. HS.

Organism-specific databases

HPAiHPA032124.

Interactioni

Protein-protein interaction databases

MINTiMINT-1208911.
STRINGi9606.ENSP00000337475.

Structurei

3D structure databases

ProteinModelPortaliQ9NPG8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The DHHC domain is required for palmitoyltransferase activity.By similarity

Sequence similaritiesi

Belongs to the DHHC palmitoyltransferase family.Curated
Contains 1 DHHC-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri149 – 19951DHHC-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Transmembrane, Transmembrane helix, Zinc-finger

Phylogenomic databases

eggNOGiKOG1312. Eukaryota.
COG5273. LUCA.
GeneTreeiENSGT00800000124109.
HOGENOMiHOG000253024.
HOVERGENiHBG054775.
InParanoidiQ9NPG8.
KOiK20003.
OMAiGAWNIRY.
OrthoDBiEOG7XPZ62.
PhylomeDBiQ9NPG8.
TreeFamiTF330931.

Family and domain databases

InterProiIPR001594. Znf_DHHC_palmitoyltrfase.
[Graphical view]
PfamiPF01529. zf-DHHC. 1 hit.
[Graphical view]
PROSITEiPS50216. ZF_DHHC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9NPG8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDFLVLFLFY LASVLMGLVL ICVCSKTHSL KGLARGGAQI FSCIIPECLQ
60 70 80 90 100
RAVHGLLHYL FHTRNHTFIV LHLVLQGMVY TEYTWEVFGY CQELELSLHY
110 120 130 140 150
LLLPYLLLGV NLFFFTLTCG TNPGIITKAN ELLFLHVYEF DEVMFPKNVR
160 170 180 190 200
CSTCDLRKPA RSKHCSVCNW CVHRFDHHCV WVNNCIGAWN IRYFLIYVLT
210 220 230 240 250
LTASAATVAI VSTTFLVHLV VMSDLYQETY IDDLGHLHVM DTVFLIQYLF
260 270 280 290 300
LTFPRIVFML GFVVVLSFLL GGYLLFVLYL AATNQTTNEW YRGDWAWCQR
310 320 330 340
CPLVAWPPSA EPQVHRNIHS HGLRSNLQEI FLPAFPCHER KKQE
Length:344
Mass (Da):39,787
Last modified:October 1, 2000 - v1
Checksum:i3D2CF22B14036908
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti33 – 331L → P in BAD97252 (Ref. 6) Curated
Sequence conflicti244 – 2441F → I in CAB66609 (PubMed:11230166).Curated
Sequence conflicti244 – 2441F → I in CAG38542 (Ref. 4) Curated
Sequence conflicti276 – 2761F → S in CAB66609 (PubMed:11230166).Curated
Sequence conflicti276 – 2761F → S in CAG38542 (Ref. 4) Curated
Sequence conflicti294 – 2941D → V in CAB66609 (PubMed:11230166).Curated
Sequence conflicti294 – 2941D → V in CAG38542 (Ref. 4) Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti53 – 531V → M.1 Publication
Corresponds to variant rs11559146 [ dbSNP | Ensembl ].
VAR_023832
Natural varianti104 – 1041P → S in a breast cancer sample; somatic mutation. 1 Publication
VAR_036260

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF201931 mRNA. Translation: AAF86867.1.
AL136674 mRNA. Translation: CAB66609.1.
AY359090 mRNA. Translation: AAQ89448.1.
CR533511 mRNA. Translation: CAG38542.1.
AK001341 mRNA. Translation: BAA91636.1.
AK223532 mRNA. Translation: BAD97252.1.
AC079742 Genomic DNA. No translation available.
CH236963 Genomic DNA. Translation: EAL23725.1.
CH878731 Genomic DNA. Translation: EAW55023.1.
BC001239 mRNA. Translation: AAH01239.1.
CCDSiCCDS5352.1.
RefSeqiNP_001127859.1. NM_001134387.1.
NP_001127860.1. NM_001134388.1.
NP_001127861.1. NM_001134389.1.
NP_060576.1. NM_018106.3.
XP_005249850.1. XM_005249793.1.
XP_005249851.1. XM_005249794.2.
XP_005249852.1. XM_005249795.1.
XP_005249853.1. XM_005249796.2.
XP_006715813.1. XM_006715750.2.
UniGeneiHs.5268.

Genome annotation databases

EnsembliENST00000335965; ENSP00000337475; ENSG00000136247.
ENST00000396706; ENSP00000379934; ENSG00000136247.
ENST00000396707; ENSP00000379935; ENSG00000136247.
ENST00000396709; ENSP00000379937; ENSG00000136247.
ENST00000396713; ENSP00000379941; ENSG00000136247.
ENST00000405731; ENSP00000385027; ENSG00000136247.
GeneIDi55146.
KEGGihsa:55146.
UCSCiuc003sqh.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF201931 mRNA. Translation: AAF86867.1.
AL136674 mRNA. Translation: CAB66609.1.
AY359090 mRNA. Translation: AAQ89448.1.
CR533511 mRNA. Translation: CAG38542.1.
AK001341 mRNA. Translation: BAA91636.1.
AK223532 mRNA. Translation: BAD97252.1.
AC079742 Genomic DNA. No translation available.
CH236963 Genomic DNA. Translation: EAL23725.1.
CH878731 Genomic DNA. Translation: EAW55023.1.
BC001239 mRNA. Translation: AAH01239.1.
CCDSiCCDS5352.1.
RefSeqiNP_001127859.1. NM_001134387.1.
NP_001127860.1. NM_001134388.1.
NP_001127861.1. NM_001134389.1.
NP_060576.1. NM_018106.3.
XP_005249850.1. XM_005249793.1.
XP_005249851.1. XM_005249794.2.
XP_005249852.1. XM_005249795.1.
XP_005249853.1. XM_005249796.2.
XP_006715813.1. XM_006715750.2.
UniGeneiHs.5268.

3D structure databases

ProteinModelPortaliQ9NPG8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-1208911.
STRINGi9606.ENSP00000337475.

PTM databases

iPTMnetiQ9NPG8.
PhosphoSiteiQ9NPG8.

Polymorphism and mutation databases

BioMutaiZDHHC4.
DMDMi28202108.

Proteomic databases

MaxQBiQ9NPG8.
PaxDbiQ9NPG8.
PRIDEiQ9NPG8.

Protocols and materials databases

DNASUi55146.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000335965; ENSP00000337475; ENSG00000136247.
ENST00000396706; ENSP00000379934; ENSG00000136247.
ENST00000396707; ENSP00000379935; ENSG00000136247.
ENST00000396709; ENSP00000379937; ENSG00000136247.
ENST00000396713; ENSP00000379941; ENSG00000136247.
ENST00000405731; ENSP00000385027; ENSG00000136247.
GeneIDi55146.
KEGGihsa:55146.
UCSCiuc003sqh.4. human.

Organism-specific databases

CTDi55146.
GeneCardsiZDHHC4.
HGNCiHGNC:18471. ZDHHC4.
HPAiHPA032124.
neXtProtiNX_Q9NPG8.
PharmGKBiPA38337.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1312. Eukaryota.
COG5273. LUCA.
GeneTreeiENSGT00800000124109.
HOGENOMiHOG000253024.
HOVERGENiHBG054775.
InParanoidiQ9NPG8.
KOiK20003.
OMAiGAWNIRY.
OrthoDBiEOG7XPZ62.
PhylomeDBiQ9NPG8.
TreeFamiTF330931.

Enzyme and pathway databases

BRENDAi2.3.1.225. 2681.

Miscellaneous databases

ChiTaRSiZDHHC4. human.
GeneWikiiZDHHC4.
GenomeRNAii55146.
PROiQ9NPG8.

Gene expression databases

BgeeiQ9NPG8.
CleanExiHS_ZDHHC4.
ExpressionAtlasiQ9NPG8. baseline and differential.
GenevisibleiQ9NPG8. HS.

Family and domain databases

InterProiIPR001594. Znf_DHHC_palmitoyltrfase.
[Graphical view]
PfamiPF01529. zf-DHHC. 1 hit.
[Graphical view]
PROSITEiPS50216. ZF_DHHC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Novel genes expressed in human dendritic cells."
    Li Y., Peng Y., Li N., Gu W., Han Z., Fu G., Chen Z.
    Submitted (NOV-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Dendritic cell.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Fetal brain.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  6. Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
    Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT MET-53.
    Tissue: Testis.
  7. "Human chromosome 7: DNA sequence and biology."
    Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S.
    , Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.-C.
    Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  8. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  9. "The DNA sequence of human chromosome 7."
    Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
    , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
    Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  10. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Cervix.
  11. Cited for: VARIANT [LARGE SCALE ANALYSIS] SER-104.

Entry informationi

Entry nameiZDHC4_HUMAN
AccessioniPrimary (citable) accession number: Q9NPG8
Secondary accession number(s): A4D2N9
, Q53EV7, Q6FIB5, Q9H0R9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 2003
Last sequence update: October 1, 2000
Last modified: June 8, 2016
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.