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Protein

Neuroglobin

Gene

NGB

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in oxygen transport in the brain. Hexacoordinate globin, displaying competitive binding of oxygen or the distal His residue to the iron atom. Not capable of penetrating cell membranes. The deoxygenated form exhibits nitrite reductase activity inhibiting cellular respiration via NO-binding to cytochrome c oxidase. Involved in neuroprotection during oxidative stress. May exert its anti-apoptotic activity by acting to reset the trigger level of mitochondrial cytochrome c release necessary to commit the cells to apoptosis.5 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi64Iron (heme distal ligand)Combined sources1 Publication1
Metal bindingi96Iron (heme proximal ligand)Combined sources1 Publication1

GO - Molecular functioni

  • heme binding Source: InterPro
  • metal ion binding Source: UniProtKB-KW
  • oxygen binding Source: InterPro
  • oxygen carrier activity Source: UniProtKB

GO - Biological processi

Keywordsi

Biological processApoptosis, Oxygen transport, Transport
LigandHeme, Iron, Metal-binding

Enzyme and pathway databases

ReactomeiR-HSA-8981607 Intracellular oxygen transport

Protein family/group databases

TCDBi1.A.107.1.4 the pore-forming globin (globin) family

Names & Taxonomyi

Protein namesi
Recommended name:
Neuroglobin
Gene namesi
Name:NGB
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

EuPathDBiHostDB:ENSG00000165553.4
HGNCiHGNC:14077 NGB
MIMi605304 gene
neXtProtiNX_Q9NPG2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Mitochondrion

Pathology & Biotechi

Organism-specific databases

DisGeNETi58157
OpenTargetsiENSG00000165553
PharmGKBiPA31612

Polymorphism and mutation databases

BioMutaiNGB
DMDMi32171399

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000533901 – 151NeuroglobinAdd BLAST151

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi46 ↔ 55Redox-active2 Publications

Post-translational modificationi

A redox disulfide bond regulates the heme pocket coordination and the rate of nitrite reduction to NO.
Phosphorylated in vitro by ERK1, ERK2 and PKA, and in vivo during hypoxia. Phosphorylation increases nitrite reductase activity.1 Publication

Keywords - PTMi

Disulfide bond, Phosphoprotein

Proteomic databases

PaxDbiQ9NPG2
PeptideAtlasiQ9NPG2
PRIDEiQ9NPG2

Expressioni

Tissue specificityi

Predominantly expressed in brain, the strongest expression is seen in the frontal lobe, the subthalamic nucleus and the thalamus.1 Publication

Gene expression databases

BgeeiENSG00000165553
CleanExiHS_NGB
ExpressionAtlasiQ9NPG2 baseline and differential
GenevisibleiQ9NPG2 HS

Organism-specific databases

HPAiHPA042615
HPA058596

Interactioni

Subunit structurei

Monomer. Homodimer and homotetramer; disulfide-linked (By similarity). Interacts with 14-3-3.By similarity3 Publications

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi121798, 14 interactors
IntActiQ9NPG2, 10 interactors
STRINGi9606.ENSP00000298352

Structurei

Secondary structure

1151
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi6 – 13Combined sources8
Turni14 – 18Combined sources5
Helixi20 – 34Combined sources15
Helixi38 – 49Combined sources12
Helixi55 – 57Combined sources3
Helixi59 – 77Combined sources19
Helixi79 – 85Combined sources7
Helixi86 – 98Combined sources13
Helixi105 – 121Combined sources17
Helixi122 – 124Combined sources3
Helixi127 – 144Combined sources18
Helixi145 – 148Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1OJ6X-ray1.95A/B/C/D1-151[»]
4MPMX-ray1.74A/B1-151[»]
ProteinModelPortaliQ9NPG2
SMRiQ9NPG2
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9NPG2

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 149GlobinAdd BLAST149

Sequence similaritiesi

Belongs to the globin family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3378 Eukaryota
COG1018 LUCA
GeneTreeiENSGT00510000048375
HOGENOMiHOG000036573
HOVERGENiHBG039321
InParanoidiQ9NPG2
KOiK21893
OMAiDHVTKVM
OrthoDBiEOG091G0R7W
PhylomeDBiQ9NPG2
TreeFamiTF333247

Family and domain databases

Gene3Di1.10.490.10, 1 hit
InterProiView protein in InterPro
IPR000971 Globin
IPR009050 Globin-like_sf
IPR012292 Globin/Proto
PfamiView protein in Pfam
PF00042 Globin, 1 hit
SUPFAMiSSF46458 SSF46458, 1 hit
PROSITEiView protein in PROSITE
PS01033 GLOBIN, 1 hit

Sequencei

Sequence statusi: Complete.

Q9NPG2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MERPEPELIR QSWRAVSRSP LEHGTVLFAR LFALEPDLLP LFQYNCRQFS
60 70 80 90 100
SPEDCLSSPE FLDHIRKVML VIDAAVTNVE DLSSLEEYLA SLGRKHRAVG
110 120 130 140 150
VKLSSFSTVG ESLLYMLEKC LGPAFTPATR AAWSQLYGAV VQAMSRGWDG

E
Length:151
Mass (Da):16,933
Last modified:October 1, 2000 - v1
Checksum:i45A292A7D77B9CE3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ245944 Genomic DNA Translation: CAC12994.1
AJ245946 mRNA Translation: CAC11133.1
AF422796 Genomic DNA Translation: AAL98923.1
AF422797 mRNA Translation: AAL98924.1
AC007375 Genomic DNA Translation: AAF63183.1
AC007954 Genomic DNA Translation: AAF62557.1
BC032509 mRNA Translation: AAH32509.1
CCDSiCCDS9856.1
RefSeqiNP_067080.1, NM_021257.3
UniGeneiHs.274363

Genome annotation databases

EnsembliENST00000298352; ENSP00000298352; ENSG00000165553
GeneIDi58157
KEGGihsa:58157
UCSCiuc001xtg.2 human

Similar proteinsi

Entry informationi

Entry nameiNGB_HUMAN
AccessioniPrimary (citable) accession number: Q9NPG2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 20, 2003
Last sequence update: October 1, 2000
Last modified: May 23, 2018
This is version 141 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

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