Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q9NPG1

- FZD3_HUMAN

UniProt

Q9NPG1 - FZD3_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Frizzled-3

Gene

FZD3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues.

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW
  2. PDZ domain binding Source: UniProtKB
  3. Wnt-activated receptor activity Source: BHF-UCL
  4. Wnt-protein binding Source: UniProtKB

GO - Biological processi

  1. canonical Wnt signaling pathway Source: UniProtKB
  2. cell proliferation in midbrain Source: RefGenome
  3. commissural neuron axon guidance Source: RefGenome
  4. establishment of planar polarity Source: RefGenome
  5. facial nucleus development Source: RefGenome
  6. gonad development Source: RefGenome
  7. G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger Source: RefGenome
  8. hair follicle development Source: Ensembl
  9. inner ear morphogenesis Source: RefGenome
  10. neural tube closure Source: RefGenome
  11. neuron differentiation Source: UniProtKB
  12. neuron migration Source: Ensembl
  13. post-anal tail morphogenesis Source: Ensembl
  14. vasculature development Source: RefGenome
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Wnt signaling pathway

Enzyme and pathway databases

ReactomeiREACT_172581. PCP/CE pathway.
REACT_172638. Asymmetric localization of PCP proteins.
REACT_172761. Ca2+ pathway.
REACT_18372. Class B/2 (Secretin family receptors).
SignaLinkiQ9NPG1.

Protein family/group databases

MEROPSiI93.001.

Names & Taxonomyi

Protein namesi
Recommended name:
Frizzled-3
Short name:
Fz-3
Short name:
hFz3
Gene namesi
Name:FZD3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 8

Organism-specific databases

HGNCiHGNC:4041. FZD3.

Subcellular locationi

GO - Cellular componenti

  1. apical part of cell Source: RefGenome
  2. apical plasma membrane Source: Ensembl
  3. axon Source: RefGenome
  4. cytoplasm Source: BHF-UCL
  5. dendrite Source: RefGenome
  6. integral component of membrane Source: UniProtKB-KW
  7. lateral plasma membrane Source: Ensembl
  8. neuronal cell body Source: RefGenome
  9. neuron projection membrane Source: RefGenome
  10. plasma membrane Source: BHF-UCL
  11. presynaptic active zone Source: RefGenome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA28458.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 22221 PublicationAdd
BLAST
Chaini23 – 666644Frizzled-3PRO_0000012982Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi28 ↔ 89PROSITE-ProRule annotation
Disulfide bondi36 ↔ 82PROSITE-ProRule annotation
Glycosylationi42 – 421N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi73 ↔ 110PROSITE-ProRule annotation
Disulfide bondi99 ↔ 133PROSITE-ProRule annotation
Disulfide bondi103 ↔ 127PROSITE-ProRule annotation
Glycosylationi265 – 2651N-linked (GlcNAc...)Sequence Analysis
Glycosylationi356 – 3561N-linked (GlcNAc...)Sequence Analysis

Post-translational modificationi

Ubiquitinated by ZNRF3, leading to its degradation by the proteasome.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Ubl conjugation

Proteomic databases

MaxQBiQ9NPG1.
PaxDbiQ9NPG1.
PRIDEiQ9NPG1.

PTM databases

PhosphoSiteiQ9NPG1.

Expressioni

Tissue specificityi

Widely expressed. Relatively high expression in the CNS, including regions of the limbic system, in kidney, pancreas, skeletal muscle, uterus and testis.

Gene expression databases

BgeeiQ9NPG1.
CleanExiHS_FZD3.
ExpressionAtlasiQ9NPG1. baseline and differential.
GenevestigatoriQ9NPG1.

Organism-specific databases

HPAiCAB024995.
HPA042320.

Interactioni

Subunit structurei

Interacts with VANGL2.By similarity

Protein-protein interaction databases

BioGridi113689. 2 interactions.
IntActiQ9NPG1. 1 interaction.
STRINGi9606.ENSP00000240093.

Structurei

3D structure databases

ProteinModelPortaliQ9NPG1.
SMRiQ9NPG1. Positions 28-136, 182-507.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini23 – 205183ExtracellularSequence AnalysisAdd
BLAST
Topological domaini227 – 23711CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini259 – 28830ExtracellularSequence AnalysisAdd
BLAST
Topological domaini310 – 32819CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini350 – 37425ExtracellularSequence AnalysisAdd
BLAST
Topological domaini396 – 42025CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini442 – 47736ExtracellularSequence AnalysisAdd
BLAST
Topological domaini499 – 666168CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei206 – 22621Helical; Name=1Sequence AnalysisAdd
BLAST
Transmembranei238 – 25821Helical; Name=2Sequence AnalysisAdd
BLAST
Transmembranei289 – 30921Helical; Name=3Sequence AnalysisAdd
BLAST
Transmembranei329 – 34921Helical; Name=4Sequence AnalysisAdd
BLAST
Transmembranei375 – 39521Helical; Name=5Sequence AnalysisAdd
BLAST
Transmembranei421 – 44121Helical; Name=6Sequence AnalysisAdd
BLAST
Transmembranei478 – 49821Helical; Name=7Sequence AnalysisAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini23 – 136114FZPROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi502 – 5076Lys-Thr-X-X-X-Trp motif, mediates interaction with the PDZ domain of Dvl family membersBy similarity

Domaini

Lys-Thr-X-X-X-Trp motif interacts with the PDZ doman of Dvl (Disheveled) family members and is involved in the activation of the Wnt/beta-catenin signaling pathway.By similarity
The FZ domain is involved in binding with Wnt ligands.By similarity

Sequence similaritiesi

Contains 1 FZ (frizzled) domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG259824.
GeneTreeiENSGT00760000118864.
HOGENOMiHOG000233237.
HOVERGENiHBG006977.
InParanoidiQ9NPG1.
KOiK02329.
OMAiMSWIVFY.
OrthoDBiEOG7M3J01.
PhylomeDBiQ9NPG1.
TreeFamiTF317907.

Family and domain databases

Gene3Di1.10.2000.10. 1 hit.
InterProiIPR000539. Frizzled.
IPR015526. Frizzled/SFRP.
IPR020067. Frizzled_dom.
IPR026553. FZD3_vertebrates.
IPR017981. GPCR_2-like.
[Graphical view]
PANTHERiPTHR11309. PTHR11309. 1 hit.
PTHR11309:SF22. PTHR11309:SF22. 1 hit.
PfamiPF01534. Frizzled. 1 hit.
PF01392. Fz. 1 hit.
[Graphical view]
PRINTSiPR00489. FRIZZLED.
SMARTiSM00063. FRI. 1 hit.
[Graphical view]
SUPFAMiSSF63501. SSF63501. 1 hit.
PROSITEiPS50038. FZ. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform Long (identifier: Q9NPG1-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAMTWIVFSL WPLTVFMGHI GGHSLFSCEP ITLRMCQDLP YNTTFMPNLL
60 70 80 90 100
NHYDQQTAAL AMEPFHPMVN LDCSRDFRPF LCALYAPICM EYGRVTLPCR
110 120 130 140 150
RLCQRAYSEC SKLMEMFGVP WPEDMECSRF PDCDEPYPRL VDLNLAGEPT
160 170 180 190 200
EGAPVAVQRD YGFWCPRELK IDPDLGYSFL HVRDCSPPCP NMYFRREELS
210 220 230 240 250
FARYFIGLIS IICLSATLFT FLTFLIDVTR FRYPERPIIF YAVCYMMVSL
260 270 280 290 300
IFFIGFLLED RVACNASIPA QYKASTVTQG SHNKACTMLF MILYFFTMAG
310 320 330 340 350
SVWWVILTIT WFLAAVPKWG SEAIEKKALL FHASAWGIPG TLTIILLAMN
360 370 380 390 400
KIEGDNISGV CFVGLYDVDA LRYFVLAPLC LYVVVGVSLL LAGIISLNRV
410 420 430 440 450
RIEIPLEKEN QDKLVKFMIR IGVFSILYLV PLLVVIGCYF YEQAYRGIWE
460 470 480 490 500
TTWIQERCRE YHIPCPYQVT QMSRPDLILF LMKYLMALIV GIPSVFWVGS
510 520 530 540 550
KKTCFEWASF FHGRRKKEIV NESRQVLQEP DFAQSLLRDP NTPIIRKSRG
560 570 580 590 600
TSTQGTSTHA SSTQLAMVDD QRSKAGSIHS KVSSYHGSLH RSRDGRYTPC
610 620 630 640 650
SYRGMEERLP HGSMSRLTDH SRHSSSHRLN EQSRHSSIRD LSNNPMTHIT
660
HGTSMNRVIE EDGTSA
Length:666
Mass (Da):76,263
Last modified:October 1, 2000 - v1
Checksum:i46D7C46E21160215
GO
Isoform Short (identifier: Q9NPG1-2)

Also known as: FZD3deltaC

Sequence is not available
Length:
Mass (Da):

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti127 – 1271C → R in BAF84169. (PubMed:14702039)Curated
Sequence conflicti402 – 4021I → V in BAF84169. (PubMed:14702039)Curated
Sequence conflicti664 – 6641T → A in BAF84169. (PubMed:14702039)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti4 – 41T → S.1 Publication
Corresponds to variant rs140115204 [ dbSNP | Ensembl ].
VAR_066960
Natural varianti199 – 1991L → M.1 Publication
VAR_066961
Natural varianti545 – 5451I → V.1 Publication
VAR_066962

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB039723 mRNA. Translation: BAA94968.1.
AJ272427 mRNA. Translation: CAB89114.1.
AY005130 mRNA. Translation: AAF89088.1.
AK291480 mRNA. Translation: BAF84169.1.
CCDSiCCDS6069.1. [Q9NPG1-1]
PIRiJC7312.
RefSeqiNP_059108.1. NM_017412.3. [Q9NPG1-1]
NP_665873.1. NM_145866.1. [Q9NPG1-1]
UniGeneiHs.40735.
Hs.734277.

Genome annotation databases

EnsembliENST00000240093; ENSP00000240093; ENSG00000104290. [Q9NPG1-1]
ENST00000537916; ENSP00000437489; ENSG00000104290. [Q9NPG1-1]
GeneIDi7976.
KEGGihsa:7976.
UCSCiuc003xgx.3. human. [Q9NPG1-1]

Polymorphism databases

DMDMi17433071.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB039723 mRNA. Translation: BAA94968.1 .
AJ272427 mRNA. Translation: CAB89114.1 .
AY005130 mRNA. Translation: AAF89088.1 .
AK291480 mRNA. Translation: BAF84169.1 .
CCDSi CCDS6069.1. [Q9NPG1-1 ]
PIRi JC7312.
RefSeqi NP_059108.1. NM_017412.3. [Q9NPG1-1 ]
NP_665873.1. NM_145866.1. [Q9NPG1-1 ]
UniGenei Hs.40735.
Hs.734277.

3D structure databases

ProteinModelPortali Q9NPG1.
SMRi Q9NPG1. Positions 28-136, 182-507.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 113689. 2 interactions.
IntActi Q9NPG1. 1 interaction.
STRINGi 9606.ENSP00000240093.

Protein family/group databases

MEROPSi I93.001.
GPCRDBi Search...

PTM databases

PhosphoSitei Q9NPG1.

Polymorphism databases

DMDMi 17433071.

Proteomic databases

MaxQBi Q9NPG1.
PaxDbi Q9NPG1.
PRIDEi Q9NPG1.

Protocols and materials databases

DNASUi 7976.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000240093 ; ENSP00000240093 ; ENSG00000104290 . [Q9NPG1-1 ]
ENST00000537916 ; ENSP00000437489 ; ENSG00000104290 . [Q9NPG1-1 ]
GeneIDi 7976.
KEGGi hsa:7976.
UCSCi uc003xgx.3. human. [Q9NPG1-1 ]

Organism-specific databases

CTDi 7976.
GeneCardsi GC08P028351.
HGNCi HGNC:4041. FZD3.
HPAi CAB024995.
HPA042320.
MIMi 606143. gene.
neXtProti NX_Q9NPG1.
PharmGKBi PA28458.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG259824.
GeneTreei ENSGT00760000118864.
HOGENOMi HOG000233237.
HOVERGENi HBG006977.
InParanoidi Q9NPG1.
KOi K02329.
OMAi MSWIVFY.
OrthoDBi EOG7M3J01.
PhylomeDBi Q9NPG1.
TreeFami TF317907.

Enzyme and pathway databases

Reactomei REACT_172581. PCP/CE pathway.
REACT_172638. Asymmetric localization of PCP proteins.
REACT_172761. Ca2+ pathway.
REACT_18372. Class B/2 (Secretin family receptors).
SignaLinki Q9NPG1.

Miscellaneous databases

ChiTaRSi FZD3. human.
GeneWikii FZD3.
GenomeRNAii 7976.
NextBioi 30495.
PROi Q9NPG1.
SOURCEi Search...

Gene expression databases

Bgeei Q9NPG1.
CleanExi HS_FZD3.
ExpressionAtlasi Q9NPG1. baseline and differential.
Genevestigatori Q9NPG1.

Family and domain databases

Gene3Di 1.10.2000.10. 1 hit.
InterProi IPR000539. Frizzled.
IPR015526. Frizzled/SFRP.
IPR020067. Frizzled_dom.
IPR026553. FZD3_vertebrates.
IPR017981. GPCR_2-like.
[Graphical view ]
PANTHERi PTHR11309. PTHR11309. 1 hit.
PTHR11309:SF22. PTHR11309:SF22. 1 hit.
Pfami PF01534. Frizzled. 1 hit.
PF01392. Fz. 1 hit.
[Graphical view ]
PRINTSi PR00489. FRIZZLED.
SMARTi SM00063. FRI. 1 hit.
[Graphical view ]
SUPFAMi SSF63501. SSF63501. 1 hit.
PROSITEi PS50038. FZ. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning and genomic structure of human frizzled-3 at chromosome 8p21."
    Kirikoshi H., Koike J., Sagara N., Saitoh T., Tokuhara M., Tanaka K., Sekihara H., Hirai M., Katoh M.
    Biochem. Biophys. Res. Commun. 271:8-14(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Fetal brain.
  2. "Identification, gene structure and expression of human frizzled-3 (FZD3)."
    Sala C.F., Formenti E., Terstappen G.C., Caricasole A.
    Biochem. Biophys. Res. Commun. 273:27-34(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Fetal brain.
  3. "Characterization of mouse frizzled-3 expression in hair follicle development and identification of the human homolog in keratinocytes."
    Hung B.S., Wang X.-Q., Cam G.R., Rothnagel J.A.
    J. Invest. Dermatol. 116:940-946(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Keratinocyte.
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  5. "Signal peptide prediction based on analysis of experimentally verified cleavage sites."
    Zhang Z., Henzel W.J.
    Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 23-37.
  6. Cited for: VARIANTS SER-4; MET-199 AND VAL-545.

Entry informationi

Entry nameiFZD3_HUMAN
AccessioniPrimary (citable) accession number: Q9NPG1
Secondary accession number(s): A8K615
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 5, 2001
Last sequence update: October 1, 2000
Last modified: October 29, 2014
This is version 126 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3