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Protein

Interleukin-23 subunit alpha

Gene

IL23A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Associates with IL12B to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis.3 Publications

GO - Biological processi

  • defense response to Gram-negative bacterium Source: BHF-UCL
  • defense response to virus Source: UniProtKB-KW
  • inflammatory response Source: UniProtKB-KW
  • innate immune response Source: UniProtKB-KW
  • negative regulation of interleukin-10 production Source: BHF-UCL
  • positive regulation of activated T cell proliferation Source: BHF-UCL
  • positive regulation of activation of JAK2 kinase activity Source: BHF-UCL
  • positive regulation of defense response to virus by host Source: BHF-UCL
  • positive regulation of granulocyte macrophage colony-stimulating factor production Source: BHF-UCL
  • positive regulation of inflammatory response Source: BHF-UCL
  • positive regulation of interferon-gamma production Source: BHF-UCL
  • positive regulation of interleukin-10 production Source: BHF-UCL
  • positive regulation of interleukin-12 production Source: BHF-UCL
  • positive regulation of interleukin-17 production Source: BHF-UCL
  • positive regulation of memory T cell differentiation Source: BHF-UCL
  • positive regulation of natural killer cell activation Source: BHF-UCL
  • positive regulation of natural killer cell proliferation Source: BHF-UCL
  • positive regulation of neutrophil chemotaxis Source: Ensembl
  • positive regulation of NF-kappaB import into nucleus Source: BHF-UCL
  • positive regulation of NK T cell activation Source: BHF-UCL
  • positive regulation of NK T cell proliferation Source: BHF-UCL
  • positive regulation of osteoclast differentiation Source: BHF-UCL
  • positive regulation of T cell mediated cytotoxicity Source: BHF-UCL
  • positive regulation of T cell proliferation Source: BHF-UCL
  • positive regulation of T-helper 17 cell lineage commitment Source: BHF-UCL
  • positive regulation of T-helper 17 type immune response Source: BHF-UCL
  • positive regulation of T-helper 1 type immune response Source: BHF-UCL
  • positive regulation of tissue remodeling Source: BHF-UCL
  • positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
  • positive regulation of tumor necrosis factor production Source: BHF-UCL
  • positive regulation of tyrosine phosphorylation of Stat3 protein Source: BHF-UCL
  • positive regulation of tyrosine phosphorylation of Stat4 protein Source: BHF-UCL
  • positive regulation of tyrosine phosphorylation of Stat5 protein Source: BHF-UCL
  • regulation of tyrosine phosphorylation of Stat1 protein Source: BHF-UCL
  • T cell proliferation Source: Ensembl
  • tissue remodeling Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Antiviral defense, Immunity, Inflammatory response, Innate immunity, Tissue remodeling

Enzyme and pathway databases

ReactomeiR-HSA-449147. Signaling by Interleukins.
SignaLinkiQ9NPF7.
SIGNORiQ9NPF7.

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-23 subunit alpha
Short name:
IL-23 subunit alpha
Short name:
IL-23-A
Alternative name(s):
Interleukin-23 subunit p19
Short name:
IL-23p19
Gene namesi
Name:IL23A
Synonyms:SGRF
ORF Names:UNQ2498/PRO5798
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:15488. IL23A.

Subcellular locationi

GO - Cellular componenti

  • extracellular region Source: Reactome
  • interleukin-23 complex Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi51561.
OpenTargetsiENSG00000110944.
PharmGKBiPA29824.

Chemistry databases

ChEMBLiCHEMBL2364154.

Polymorphism and mutation databases

BioMutaiIL23A.
DMDMi74761641.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_000025948820 – 189Interleukin-23 subunit alphaAdd BLAST170

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ9NPF7.
PRIDEiQ9NPF7.

Expressioni

Tissue specificityi

Secreted by activated dendritic and phagocytic cells and keratinocytes. Also expressed by dermal Langerhans cells (at protein level).2 Publications

Developmental stagei

Expressed by newborns dendritic cells.1 Publication

Inductioni

Up-regulated by a wide array of pathogens and pathogen-products together with self-signals for danger or injury. Up-regulated in psoriatic dermal tissues, in dendritic cells of multiple sclerosis patients and in tumors.7 Publications

Gene expression databases

BgeeiENSG00000110944.
CleanExiHS_IL23A.
GenevisibleiQ9NPF7. HS.

Organism-specific databases

HPAiHPA001554.

Interactioni

Subunit structurei

Heterodimer with IL12B; disulfide-linked. The heterodimer is known as interleukin IL-23.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
IL12BP294604EBI-2481154,EBI-1029614
PEX19P408555EBI-2481154,EBI-594747

Protein-protein interaction databases

BioGridi119611. 7 interactors.
IntActiQ9NPF7. 4 interactors.
STRINGi9606.ENSP00000228534.

Structurei

Secondary structure

1189
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi30 – 46Combined sources17
Turni49 – 51Combined sources3
Helixi61 – 63Combined sources3
Helixi73 – 75Combined sources3
Helixi79 – 85Combined sources7
Helixi87 – 104Combined sources18
Helixi107 – 110Combined sources4
Beta strandi111 – 113Combined sources3
Helixi120 – 135Combined sources16
Beta strandi136 – 138Combined sources3
Helixi155 – 186Combined sources32

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3D85X-ray1.90C20-189[»]
3D87X-ray2.90A/C20-189[»]
3DUHX-ray2.30C/D20-189[»]
3QWRX-ray3.25B20-189[»]
4GRWX-ray2.55A/C1-189[»]
4OE8X-ray1.74B1-189[»]
4OG9X-ray3.39B1-189[»]
ProteinModelPortaliQ9NPF7.
SMRiQ9NPF7.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9NPF7.

Family & Domainsi

Sequence similaritiesi

Belongs to the IL-6 superfamily.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IGBY. Eukaryota.
ENOG411142Q. LUCA.
GeneTreeiENSGT00390000006482.
HOGENOMiHOG000048728.
HOVERGENiHBG081786.
InParanoidiQ9NPF7.
KOiK05426.
OMAiPQGLKDN.
OrthoDBiEOG091G0Q9J.
PhylomeDBiQ9NPF7.
TreeFamiTF337234.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR010831. IL-23_alpha.
[Graphical view]
PANTHERiPTHR15947. PTHR15947. 1 hit.
PfamiPF16649. IL23. 1 hit.
[Graphical view]
SUPFAMiSSF47266. SSF47266. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9NPF7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLGSRAVMLL LLLPWTAQGR AVPGGSSPAW TQCQQLSQKL CTLAWSAHPL
60 70 80 90 100
VGHMDLREEG DEETTNDVPH IQCGDGCDPQ GLRDNSQFCL QRIHQGLIFY
110 120 130 140 150
EKLLGSDIFT GEPSLLPDSP VGQLHASLLG LSQLLQPEGH HWETQQIPSL
160 170 180
SPSQPWQRLL LRFKILRSLQ AFVAVAARVF AHGAATLSP
Length:189
Mass (Da):20,730
Last modified:October 1, 2000 - v1
Checksum:i51B5C0F188EC1B9F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti122G → A in AAG37232 (PubMed:11114383).Curated1
Sequence conflicti147I → M in AAH66267 (PubMed:15489334).Curated1
Sequence conflicti168S → N in AAH66267 (PubMed:15489334).Curated1
Sequence conflicti173V → A in AAH66269 (PubMed:15489334).Curated1
Sequence conflicti189P → L in AAH66269 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF301620 mRNA. Translation: AAG37232.1.
AB030000 mRNA. Translation: BAA93686.1.
AB030001 Genomic DNA. Translation: BAA93687.1.
AY359083 mRNA. Translation: AAQ89442.1.
BC066267 mRNA. Translation: AAH66267.1.
BC066268 mRNA. Translation: AAH66268.1.
BC066269 mRNA. Translation: AAH66269.1.
BC067511 mRNA. Translation: AAH67511.1.
BC067512 mRNA. Translation: AAH67512.1.
BC067513 mRNA. Translation: AAH67513.1.
CCDSiCCDS8916.1.
RefSeqiNP_057668.1. NM_016584.2.
XP_011536779.1. XM_011538477.2.
UniGeneiHs.382212.
Hs.98309.

Genome annotation databases

EnsembliENST00000228534; ENSP00000228534; ENSG00000110944.
GeneIDi51561.
KEGGihsa:51561.
UCSCiuc001sla.4. human.

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF301620 mRNA. Translation: AAG37232.1.
AB030000 mRNA. Translation: BAA93686.1.
AB030001 Genomic DNA. Translation: BAA93687.1.
AY359083 mRNA. Translation: AAQ89442.1.
BC066267 mRNA. Translation: AAH66267.1.
BC066268 mRNA. Translation: AAH66268.1.
BC066269 mRNA. Translation: AAH66269.1.
BC067511 mRNA. Translation: AAH67511.1.
BC067512 mRNA. Translation: AAH67512.1.
BC067513 mRNA. Translation: AAH67513.1.
CCDSiCCDS8916.1.
RefSeqiNP_057668.1. NM_016584.2.
XP_011536779.1. XM_011538477.2.
UniGeneiHs.382212.
Hs.98309.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3D85X-ray1.90C20-189[»]
3D87X-ray2.90A/C20-189[»]
3DUHX-ray2.30C/D20-189[»]
3QWRX-ray3.25B20-189[»]
4GRWX-ray2.55A/C1-189[»]
4OE8X-ray1.74B1-189[»]
4OG9X-ray3.39B1-189[»]
ProteinModelPortaliQ9NPF7.
SMRiQ9NPF7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119611. 7 interactors.
IntActiQ9NPF7. 4 interactors.
STRINGi9606.ENSP00000228534.

Chemistry databases

ChEMBLiCHEMBL2364154.

Polymorphism and mutation databases

BioMutaiIL23A.
DMDMi74761641.

Proteomic databases

PaxDbiQ9NPF7.
PRIDEiQ9NPF7.

Protocols and materials databases

DNASUi51561.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000228534; ENSP00000228534; ENSG00000110944.
GeneIDi51561.
KEGGihsa:51561.
UCSCiuc001sla.4. human.

Organism-specific databases

CTDi51561.
DisGeNETi51561.
GeneCardsiIL23A.
HGNCiHGNC:15488. IL23A.
HPAiHPA001554.
MIMi605580. gene.
neXtProtiNX_Q9NPF7.
OpenTargetsiENSG00000110944.
PharmGKBiPA29824.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IGBY. Eukaryota.
ENOG411142Q. LUCA.
GeneTreeiENSGT00390000006482.
HOGENOMiHOG000048728.
HOVERGENiHBG081786.
InParanoidiQ9NPF7.
KOiK05426.
OMAiPQGLKDN.
OrthoDBiEOG091G0Q9J.
PhylomeDBiQ9NPF7.
TreeFamiTF337234.

Enzyme and pathway databases

ReactomeiR-HSA-449147. Signaling by Interleukins.
SignaLinkiQ9NPF7.
SIGNORiQ9NPF7.

Miscellaneous databases

EvolutionaryTraceiQ9NPF7.
GeneWikiiInterleukin_23.
GenomeRNAii51561.
PROiQ9NPF7.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000110944.
CleanExiHS_IL23A.
GenevisibleiQ9NPF7. HS.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR010831. IL-23_alpha.
[Graphical view]
PANTHERiPTHR15947. PTHR15947. 1 hit.
PfamiPF16649. IL23. 1 hit.
[Graphical view]
SUPFAMiSSF47266. SSF47266. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiIL23A_HUMAN
AccessioniPrimary (citable) accession number: Q9NPF7
Secondary accession number(s): Q6NZ80, Q6NZ82, Q9H2A5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: October 1, 2000
Last modified: November 30, 2016
This is version 124 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.