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Protein

DNA methyltransferase 1-associated protein 1

Gene

DMAP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in transcription repression and activation. Its interaction with HDAC2 may provide a mechanism for histone deacetylation in heterochromatin following replication of DNA at late firing origins. Can also repress transcription independently of histone deacetylase activity. May specifically potentiate DAXX-mediated repression of glucocorticoid receptor-dependent transcription. Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. Participates in the nuclear localization of URI1 and increases its transcriptional corepressor activity.4 Publications

GO - Molecular functioni

GO - Biological processi

  • chromatin remodeling Source: InterPro
  • DNA methylation Source: UniProtKB
  • DNA repair Source: InterPro
  • histone H2A acetylation Source: UniProtKB
  • histone H4 acetylation Source: UniProtKB
  • negative regulation of transcription, DNA-templated Source: UniProtKB
  • negative regulation of transcription by RNA polymerase II Source: UniProtKB
  • positive regulation of protein import into nucleus Source: UniProtKB
  • regulation of growth Source: UniProtKB-KW
  • response to ethanol Source: Ensembl
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionActivator, Chromatin regulator, Repressor
Biological processGrowth regulation, Transcription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-HSA-3214847 HATs acetylate histones

Names & Taxonomyi

Protein namesi
Recommended name:
DNA methyltransferase 1-associated protein 1
Short name:
DNMAP1
Short name:
DNMT1-associated protein 1
Gene namesi
Name:DMAP1
Synonyms:KIAA1425
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000178028.13
HGNCiHGNC:18291 DMAP1
MIMi605077 gene
neXtProtiNX_Q9NPF5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi55929
OpenTargetsiENSG00000178028
PharmGKBiPA134927315

Polymorphism and mutation databases

BioMutaiDMAP1
DMDMi20138031

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000799351 – 467DNA methyltransferase 1-associated protein 1Add BLAST467

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki27Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki214Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei445PhosphothreonineCombined sources1
Modified residuei448PhosphoserineCombined sources1

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ9NPF5
MaxQBiQ9NPF5
PaxDbiQ9NPF5
PeptideAtlasiQ9NPF5
PRIDEiQ9NPF5

PTM databases

iPTMnetiQ9NPF5
PhosphoSitePlusiQ9NPF5

Expressioni

Gene expression databases

BgeeiENSG00000178028
CleanExiHS_DMAP1
ExpressionAtlasiQ9NPF5 baseline and differential
GenevisibleiQ9NPF5 HS

Organism-specific databases

HPAiCAB033018
HPA028419

Interactioni

Subunit structurei

Component of the NuA4 histone acetyltransferase complex which contains the catalytic subunit KAT5/TIP60 and the subunits EP400, TRRAP/PAF400, BRD8/SMAP, EPC1, DMAP1/DNMAP1, RUVBL1/TIP49, RUVBL2, ING3, actin, ACTL6A/BAF53A, MORF4L1/MRG15, MORF4L2/MRGX, MRGBP, YEATS4/GAS41, VPS72/YL1 and MEAF6. Component of a NuA4-related complex which contains EP400, TRRAP/PAF400, SRCAP, BRD8/SMAP, EPC1, DMAP1/DNMAP1, RUVBL1/TIP49, RUVBL2, actin, ACTL6A/BAF53A, VPS72 and YEATS4/GAS41. DMAP1 also forms a complex with DNMT1 and HDAC2. Throughout S phase it interacts directly with the N-terminus of DNMT1, which serves to recruit DMAP1 to replication foci. DMAP1 interacts with ING1, a component of the mSin3A transcription repressor complex, although this interaction is not required for recruitment of ING1 to heterochromatin. Interacts directly with the transcriptional corepressor TSG101. Interacts with the pro-apoptotic protein DAXX. Interacts with URI1.6 Publications

GO - Molecular functioni

  • RNA polymerase II repressing transcription factor binding Source: UniProtKB

Protein-protein interaction databases

BioGridi121004, 70 interactors
CORUMiQ9NPF5
IntActiQ9NPF5, 35 interactors
MINTiQ9NPF5
STRINGi9606.ENSP00000312697

Structurei

Secondary structure

1467
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi140 – 146Combined sources7
Helixi154 – 166Combined sources13
Turni167 – 169Combined sources3
Helixi171 – 177Combined sources7
Turni180 – 182Combined sources3
Helixi188 – 205Combined sources18

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3HM5X-ray1.80A121-212[»]
4IEJX-ray1.45A121-212[»]
ProteinModelPortaliQ9NPF5
SMRiQ9NPF5
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9NPF5

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini149 – 199SANTAdd BLAST51

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili225 – 275Sequence analysisAdd BLAST51

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi454 – 460Poly-Ser7

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG2656 Eukaryota
ENOG410XSA4 LUCA
GeneTreeiENSGT00390000016466
HOVERGENiHBG051364
InParanoidiQ9NPF5
KOiK11324
OMAiCKRFDLR
OrthoDBiEOG091G0B27
PhylomeDBiQ9NPF5
TreeFamiTF354261

Family and domain databases

InterProiView protein in InterPro
IPR032563 DAMP1_SANT-like
IPR008468 DMAP1
IPR027109 Swc4/Dmap1
PANTHERiPTHR12855 PTHR12855, 2 hits
PfamiView protein in Pfam
PF05499 DMAP1, 1 hit
PF16282 SANT_DAMP1_like, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD492828 DMAP1, 1 hit

Sequencei

Sequence statusi: Complete.

Q9NPF5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATGADVRDI LELGGPEGDA ASGTISKKDI INPDKKKSKK SSETLTFKRP
60 70 80 90 100
EGMHREVYAL LYSDKKDAPP LLPSDTGQGY RTVKAKLGSK KVRPWKWMPF
110 120 130 140 150
TNPARKDGAM FFHWRRAAEE GKDYPFARFN KTVQVPVYSE QEYQLYLHDD
160 170 180 190 200
AWTKAETDHL FDLSRRFDLR FVVIHDRYDH QQFKKRSVED LKERYYHICA
210 220 230 240 250
KLANVRAVPG TDLKIPVFDA GHERRRKEQL ERLYNRTPEQ VAEEEYLLQE
260 270 280 290 300
LRKIEARKKE REKRSQDLQK LITAADTTAE QRRTERKAPK KKLPQKKEAE
310 320 330 340 350
KPAVPETAGI KFPDFKSAGV TLRSQRMKLP SSVGQKKIKA LEQMLLELGV
360 370 380 390 400
ELSPTPTEEL VHMFNELRSD LVLLYELKQA CANCEYELQM LRHRHEALAR
410 420 430 440 450
AGVLGGPATP ASGPGPASAE PAVTEPGLGP DPKDTIIDVV GAPLTPNSRK
460
RRESASSSSS VKKAKKP
Length:467
Mass (Da):52,993
Last modified:October 1, 2000 - v1
Checksum:i54500B252E076A29
GO

Sequence cautioni

The sequence BAA92663 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti135V → E in CAB66592 (PubMed:11230166).Curated1
Sequence conflicti135V → E in CAL38490 (PubMed:11230166).Curated1
Sequence conflicti150D → N in CAB66592 (PubMed:11230166).Curated1
Sequence conflicti150D → N in CAL38490 (PubMed:11230166).Curated1
Sequence conflicti171F → L in CAD97886 (PubMed:17974005).Curated1
Sequence conflicti424T → S in CAB66592 (PubMed:11230166).Curated1
Sequence conflicti424T → S in CAL38490 (PubMed:11230166).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF265228 mRNA Translation: AAF87079.1
AL137200 mRNA Translation: CAB69910.1
AB037846 mRNA Translation: BAA92663.1 Different initiation.
AL136657 mRNA Translation: CAB66592.1
AM393614 mRNA Translation: CAL38490.1
AK021605 mRNA Translation: BAB13854.1
AK289366 mRNA Translation: BAF82055.1
AL035417 Genomic DNA No translation available.
CH471059 Genomic DNA Translation: EAX07046.1
CH471059 Genomic DNA Translation: EAX07047.1
CH471059 Genomic DNA Translation: EAX07048.1
CH471059 Genomic DNA Translation: EAX07051.1
BC002855 mRNA Translation: AAH02855.1
BC008053 mRNA Translation: AAH08053.1
BX537895 mRNA Translation: CAD97886.1
CCDSiCCDS509.1
RefSeqiNP_001029195.1, NM_001034023.1
NP_001029196.1, NM_001034024.1
NP_061973.1, NM_019100.4
XP_016857297.1, XM_017001808.1
UniGeneiHs.8008

Genome annotation databases

EnsembliENST00000315913; ENSP00000312697; ENSG00000178028
ENST00000361745; ENSP00000354697; ENSG00000178028
ENST00000372289; ENSP00000361363; ENSG00000178028
GeneIDi55929
KEGGihsa:55929
UCSCiuc001clq.2 human

Similar proteinsi

Entry informationi

Entry nameiDMAP1_HUMAN
AccessioniPrimary (citable) accession number: Q9NPF5
Secondary accession number(s): A8K001
, D3DPY8, Q0JSM4, Q5TG41, Q7Z3H7, Q9H0S8, Q9P2C2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2002
Last sequence update: October 1, 2000
Last modified: May 23, 2018
This is version 174 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome
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Main funding by: National Institutes of Health