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Q9NPE2

- NGRN_HUMAN

UniProt

Q9NPE2 - NGRN_HUMAN

Protein

Neugrin

Gene

NGRN

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 117 (01 Oct 2014)
      Sequence version 2 (05 Oct 2010)
      Previous versions | rss
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    Functioni

    May be involved in neuronal differentiation.

    GO - Molecular functioni

    1. poly(A) RNA binding Source: UniProtKB

    GO - Biological processi

    1. neuron differentiation Source: UniProtKB

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Differentiation, Neurogenesis

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Neugrin
    Alternative name(s):
    Mesenchymal stem cell protein DSC92
    Neurite outgrowth-associated protein
    Spinal cord-derived protein FI58G
    Gene namesi
    Name:NGRN
    Synonyms:FI58G
    ORF Names:HT020
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 15

    Organism-specific databases

    HGNCiHGNC:18077. NGRN.

    Subcellular locationi

    Nucleus 1 Publication. Secreted Curated

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell
    2. nucleus Source: UniProtKB

    Keywords - Cellular componenti

    Nucleus, Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA142671265.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1515Sequence AnalysisAdd
    BLAST
    Chaini16 – 291276NeugrinPRO_0000294483Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei41 – 411Phosphoserine1 Publication
    Glycosylationi158 – 1581N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi186 – 1861N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi268 – 2681N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein, Phosphoprotein

    Proteomic databases

    MaxQBiQ9NPE2.
    PaxDbiQ9NPE2.
    PRIDEiQ9NPE2.

    PTM databases

    PhosphoSiteiQ9NPE2.

    Expressioni

    Tissue specificityi

    Expressed at high levels in heart, brain and skeletal muscle. In brain, mainly expressed in neurons rather than glial cells.1 Publication

    Inductioni

    Highly up-regulated in neuroblastostoma cells by retinoic acid treatment inducing neurite outgrowth.

    Gene expression databases

    BgeeiQ9NPE2.
    CleanExiHS_NGRN.
    GenevestigatoriQ9NPE2.

    Organism-specific databases

    HPAiHPA041367.

    Interactioni

    Protein-protein interaction databases

    BioGridi119482. 2 interactions.
    IntActiQ9NPE2. 3 interactions.
    MINTiMINT-4714594.
    STRINGi9606.ENSP00000368389.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9NPE2.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the neugrin family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG76499.
    HOGENOMiHOG000252993.
    HOVERGENiHBG108182.
    InParanoidiQ9NPE2.
    OMAiTNTPRRQ.
    OrthoDBiEOG7QC7W1.
    PhylomeDBiQ9NPE2.
    TreeFamiTF324463.

    Family and domain databases

    InterProiIPR010487. Neugrin-related.
    [Graphical view]
    PfamiPF06413. Neugrin. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9NPE2-2) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAVTLSLLLG GRVCAAVTRC GFATRGVAGP GPIGREPDPD SDWEPEEREL    50
    QEVESTLKRQ KQAIRFQKIR RQMEAPGAPP RTLTWEAMEQ IRYLHEEFPE 100
    SWSVPRLAEG FDVSTDVIRR VLKSKFLPTL EQKLKQDQKV LKKAGLAHSL 150
    QHLRGSGNTS KLLPAGHSVS GSLLMPGHEA SSKDPNHSTA LKVIESDTHR 200
    TNTPRRRKGR NKEIQDLEES FVPVAAPLGH PRELQKYSSD SESPRGTGSG 250
    ALPSGQKLEE LKAEEPDNFS SKVVQRGREF FDSNGNFLYR I 291
    Length:291
    Mass (Da):32,408
    Last modified:October 5, 2010 - v2
    Checksum:iF0480D6D94BE2ACE
    GO
    Isoform 2 (identifier: Q9NPE2-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         55-64: STLKRQKQAI → RYRLLPGPSA
         65-291: Missing.

    Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

    Show »
    Length:64
    Mass (Da):6,851
    Checksum:i1BA91466FF84D107
    GO

    Sequence cautioni

    The sequence BAG35525.1 differs from that shown. Reason: N-terminus does not match isoform 2.
    The sequence AAG09725.1 differs from that shown. Reason: Frameshift at position 47.
    The sequence BAB21533.1 differs from that shown. Reason: Frameshift at position 47.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti28 – 281A → C in BG719592. 1 PublicationCurated
    Sequence conflicti32 – 321P → R in AAG09725. (PubMed:10931946)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti174 – 1741L → F.
    Corresponds to variant rs11073922 [ dbSNP | Ensembl ].
    VAR_053905
    Natural varianti267 – 2671D → G.
    Corresponds to variant rs16944113 [ dbSNP | Ensembl ].
    VAR_053906

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei55 – 6410STLKRQKQAI → RYRLLPGPSA in isoform 2. 6 PublicationsVSP_039710
    Alternative sequencei65 – 291227Missing in isoform 2. 6 PublicationsVSP_039711Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB029315 mRNA. Translation: BAB21533.1. Sequence problems.
    AF242770 mRNA. Translation: AAF65447.1. Sequence problems.
    AL360142 mRNA. Translation: CAB96088.1. Sequence problems.
    AL834503 mRNA. Translation: CAD39160.1. Sequence problems.
    AC091167 Genomic DNA. No translation available.
    BC001682 mRNA. Translation: AAH01682.1. Sequence problems.
    BC007222 mRNA. Translation: AAH07222.1. Sequence problems.
    BC009389 mRNA. Translation: AAH09389.1. Sequence problems.
    BC017192 mRNA. Translation: AAH17192.1. Sequence problems.
    BC096824 mRNA. Translation: AAH96824.1.
    BG719592 mRNA. No translation available.
    AF225423 mRNA. Translation: AAG09725.1. Sequence problems.
    AY049780 mRNA. Translation: AAL15437.1.
    AK312641 mRNA. Translation: BAG35525.1. Sequence problems.
    CCDSiCCDS32329.1. [Q9NPE2-2]
    PIRiJC7563.
    RefSeqiNP_001028260.2. NM_001033088.1. [Q9NPE2-2]
    UniGeneiHs.135471.
    Hs.715556.

    Genome annotation databases

    EnsembliENST00000379095; ENSP00000368389; ENSG00000182768. [Q9NPE2-2]
    GeneIDi51335.
    KEGGihsa:51335.
    UCSCiuc002bpf.1. human. [Q9NPE2-2]

    Polymorphism databases

    DMDMi306526226.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB029315 mRNA. Translation: BAB21533.1 . Sequence problems.
    AF242770 mRNA. Translation: AAF65447.1 . Sequence problems.
    AL360142 mRNA. Translation: CAB96088.1 . Sequence problems.
    AL834503 mRNA. Translation: CAD39160.1 . Sequence problems.
    AC091167 Genomic DNA. No translation available.
    BC001682 mRNA. Translation: AAH01682.1 . Sequence problems.
    BC007222 mRNA. Translation: AAH07222.1 . Sequence problems.
    BC009389 mRNA. Translation: AAH09389.1 . Sequence problems.
    BC017192 mRNA. Translation: AAH17192.1 . Sequence problems.
    BC096824 mRNA. Translation: AAH96824.1 .
    BG719592 mRNA. No translation available.
    AF225423 mRNA. Translation: AAG09725.1 . Sequence problems.
    AY049780 mRNA. Translation: AAL15437.1 .
    AK312641 mRNA. Translation: BAG35525.1 . Sequence problems.
    CCDSi CCDS32329.1. [Q9NPE2-2 ]
    PIRi JC7563.
    RefSeqi NP_001028260.2. NM_001033088.1. [Q9NPE2-2 ]
    UniGenei Hs.135471.
    Hs.715556.

    3D structure databases

    ProteinModelPortali Q9NPE2.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 119482. 2 interactions.
    IntActi Q9NPE2. 3 interactions.
    MINTi MINT-4714594.
    STRINGi 9606.ENSP00000368389.

    PTM databases

    PhosphoSitei Q9NPE2.

    Polymorphism databases

    DMDMi 306526226.

    Proteomic databases

    MaxQBi Q9NPE2.
    PaxDbi Q9NPE2.
    PRIDEi Q9NPE2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000379095 ; ENSP00000368389 ; ENSG00000182768 . [Q9NPE2-2 ]
    GeneIDi 51335.
    KEGGi hsa:51335.
    UCSCi uc002bpf.1. human. [Q9NPE2-2 ]

    Organism-specific databases

    CTDi 51335.
    GeneCardsi GC15P090808.
    H-InvDB HIX0012575.
    HIX0172837.
    HGNCi HGNC:18077. NGRN.
    HPAi HPA041367.
    neXtProti NX_Q9NPE2.
    PharmGKBi PA142671265.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG76499.
    HOGENOMi HOG000252993.
    HOVERGENi HBG108182.
    InParanoidi Q9NPE2.
    OMAi TNTPRRQ.
    OrthoDBi EOG7QC7W1.
    PhylomeDBi Q9NPE2.
    TreeFami TF324463.

    Miscellaneous databases

    GenomeRNAii 51335.
    NextBioi 54759.
    PROi Q9NPE2.

    Gene expression databases

    Bgeei Q9NPE2.
    CleanExi HS_NGRN.
    Genevestigatori Q9NPE2.

    Family and domain databases

    InterProi IPR010487. Neugrin-related.
    [Graphical view ]
    Pfami PF06413. Neugrin. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Two novel genes, human neugrin and mouse m-neugrin, are upregulated with neuronal differentiation in neuroblastoma cells."
      Ishigaki S., Niwa J., Yoshihara T., Mitsuma N., Doyu M., Sobue G.
      Biochem. Biophys. Res. Commun. 279:526-533(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    2. "cDNA DSC92 expressed by osteogenic human mesenchymal stem cells."
      van den Bos C., Mbalaviele G., Thiede M.
      Submitted (MAR-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
      Tissue: Mesenchymal stem cell.
    3. The European IMAGE consortium
      Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Kidney.
    5. "Analysis of the DNA sequence and duplication history of human chromosome 15."
      Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K., Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N., Abouelleil A.
      , Arachchi H.M., Baradarani L., Birditt B., Bloom S., Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K., DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J., Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E., Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B., Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R., O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M.B., Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S., Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C.
      Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: Brain, Chondrosarcoma, Lung, Muscle, Placenta and Testis.
    7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 20-291 (ISOFORM 2).
    8. Hu X., Xu Y., Peng X., Yuan J., Qiang B.
      Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 73-291 (ISOFORM 1).
    9. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: PARTIAL NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Neuroblastoma.
    10. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    11. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-41, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.

    Entry informationi

    Entry nameiNGRN_HUMAN
    AccessioniPrimary (citable) accession number: Q9NPE2
    Secondary accession number(s): B2R6M8, Q4V9L7, Q9HBL4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 10, 2007
    Last sequence update: October 5, 2010
    Last modified: October 1, 2014
    This is version 117 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 15
      Human chromosome 15: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3