SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q9NPE2

- NGRN_HUMAN

UniProt

Q9NPE2 - NGRN_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Neugrin

Gene
NGRN, FI58G, HT020
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

May be involved in neuronal differentiation.

GO - Molecular functioni

  1. poly(A) RNA binding Source: UniProtKB

GO - Biological processi

  1. neuron differentiation Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation, Neurogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Neugrin
Alternative name(s):
Mesenchymal stem cell protein DSC92
Neurite outgrowth-associated protein
Spinal cord-derived protein FI58G
Gene namesi
Name:NGRN
Synonyms:FI58G
ORF Names:HT020
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 15

Organism-specific databases

HGNCiHGNC:18077. NGRN.

Subcellular locationi

Nucleus. Secreted Reviewed prediction 1 Publication

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
  2. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus, Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142671265.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1515 Reviewed predictionAdd
BLAST
Chaini16 – 291276NeugrinPRO_0000294483Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei41 – 411Phosphoserine1 Publication
Glycosylationi158 – 1581N-linked (GlcNAc...) Reviewed prediction
Glycosylationi186 – 1861N-linked (GlcNAc...) Reviewed prediction
Glycosylationi268 – 2681N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ9NPE2.
PaxDbiQ9NPE2.
PRIDEiQ9NPE2.

PTM databases

PhosphoSiteiQ9NPE2.

Expressioni

Tissue specificityi

Expressed at high levels in heart, brain and skeletal muscle. In brain, mainly expressed in neurons rather than glial cells.1 Publication

Inductioni

Highly up-regulated in neuroblastostoma cells by retinoic acid treatment inducing neurite outgrowth.

Gene expression databases

BgeeiQ9NPE2.
CleanExiHS_NGRN.
GenevestigatoriQ9NPE2.

Organism-specific databases

HPAiHPA041367.

Interactioni

Protein-protein interaction databases

BioGridi119482. 2 interactions.
IntActiQ9NPE2. 3 interactions.
MINTiMINT-4714594.
STRINGi9606.ENSP00000368389.

Structurei

3D structure databases

ProteinModelPortaliQ9NPE2.

Family & Domainsi

Sequence similaritiesi

Belongs to the neugrin family.

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG76499.
HOGENOMiHOG000252993.
HOVERGENiHBG108182.
InParanoidiQ9NPE2.
OMAiTNTPRRQ.
OrthoDBiEOG7QC7W1.
PhylomeDBiQ9NPE2.
TreeFamiTF324463.

Family and domain databases

InterProiIPR010487. Neugrin-related.
[Graphical view]
PfamiPF06413. Neugrin. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9NPE2-2) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MAVTLSLLLG GRVCAAVTRC GFATRGVAGP GPIGREPDPD SDWEPEEREL    50
QEVESTLKRQ KQAIRFQKIR RQMEAPGAPP RTLTWEAMEQ IRYLHEEFPE 100
SWSVPRLAEG FDVSTDVIRR VLKSKFLPTL EQKLKQDQKV LKKAGLAHSL 150
QHLRGSGNTS KLLPAGHSVS GSLLMPGHEA SSKDPNHSTA LKVIESDTHR 200
TNTPRRRKGR NKEIQDLEES FVPVAAPLGH PRELQKYSSD SESPRGTGSG 250
ALPSGQKLEE LKAEEPDNFS SKVVQRGREF FDSNGNFLYR I 291
Length:291
Mass (Da):32,408
Last modified:October 5, 2010 - v2
Checksum:iF0480D6D94BE2ACE
GO
Isoform 2 (identifier: Q9NPE2-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     55-64: STLKRQKQAI → RYRLLPGPSA
     65-291: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

Show »
Length:64
Mass (Da):6,851
Checksum:i1BA91466FF84D107
GO

Sequence cautioni

The sequence BAG35525.1 differs from that shown. Reason: N-terminus does not match isoform 2.
The sequence AAG09725.1 differs from that shown. Reason: Frameshift at position 47.
The sequence BAB21533.1 differs from that shown. Reason: Frameshift at position 47.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti174 – 1741L → F.
Corresponds to variant rs11073922 [ dbSNP | Ensembl ].
VAR_053905
Natural varianti267 – 2671D → G.
Corresponds to variant rs16944113 [ dbSNP | Ensembl ].
VAR_053906

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei55 – 6410STLKRQKQAI → RYRLLPGPSA in isoform 2. VSP_039710
Alternative sequencei65 – 291227Missing in isoform 2. VSP_039711Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti28 – 281A → C in BG719592. 1 Publication
Sequence conflicti32 – 321P → R in AAG09725. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB029315 mRNA. Translation: BAB21533.1. Sequence problems.
AF242770 mRNA. Translation: AAF65447.1. Sequence problems.
AL360142 mRNA. Translation: CAB96088.1. Sequence problems.
AL834503 mRNA. Translation: CAD39160.1. Sequence problems.
AC091167 Genomic DNA. No translation available.
BC001682 mRNA. Translation: AAH01682.1. Sequence problems.
BC007222 mRNA. Translation: AAH07222.1. Sequence problems.
BC009389 mRNA. Translation: AAH09389.1. Sequence problems.
BC017192 mRNA. Translation: AAH17192.1. Sequence problems.
BC096824 mRNA. Translation: AAH96824.1.
BG719592 mRNA. No translation available.
AF225423 mRNA. Translation: AAG09725.1. Sequence problems.
AY049780 mRNA. Translation: AAL15437.1.
AK312641 mRNA. Translation: BAG35525.1. Sequence problems.
CCDSiCCDS32329.1. [Q9NPE2-2]
PIRiJC7563.
RefSeqiNP_001028260.2. NM_001033088.1. [Q9NPE2-2]
UniGeneiHs.135471.
Hs.715556.

Genome annotation databases

EnsembliENST00000379095; ENSP00000368389; ENSG00000182768. [Q9NPE2-2]
GeneIDi51335.
KEGGihsa:51335.
UCSCiuc002bpf.1. human. [Q9NPE2-2]

Polymorphism databases

DMDMi306526226.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB029315 mRNA. Translation: BAB21533.1 . Sequence problems.
AF242770 mRNA. Translation: AAF65447.1 . Sequence problems.
AL360142 mRNA. Translation: CAB96088.1 . Sequence problems.
AL834503 mRNA. Translation: CAD39160.1 . Sequence problems.
AC091167 Genomic DNA. No translation available.
BC001682 mRNA. Translation: AAH01682.1 . Sequence problems.
BC007222 mRNA. Translation: AAH07222.1 . Sequence problems.
BC009389 mRNA. Translation: AAH09389.1 . Sequence problems.
BC017192 mRNA. Translation: AAH17192.1 . Sequence problems.
BC096824 mRNA. Translation: AAH96824.1 .
BG719592 mRNA. No translation available.
AF225423 mRNA. Translation: AAG09725.1 . Sequence problems.
AY049780 mRNA. Translation: AAL15437.1 .
AK312641 mRNA. Translation: BAG35525.1 . Sequence problems.
CCDSi CCDS32329.1. [Q9NPE2-2 ]
PIRi JC7563.
RefSeqi NP_001028260.2. NM_001033088.1. [Q9NPE2-2 ]
UniGenei Hs.135471.
Hs.715556.

3D structure databases

ProteinModelPortali Q9NPE2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 119482. 2 interactions.
IntActi Q9NPE2. 3 interactions.
MINTi MINT-4714594.
STRINGi 9606.ENSP00000368389.

PTM databases

PhosphoSitei Q9NPE2.

Polymorphism databases

DMDMi 306526226.

Proteomic databases

MaxQBi Q9NPE2.
PaxDbi Q9NPE2.
PRIDEi Q9NPE2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000379095 ; ENSP00000368389 ; ENSG00000182768 . [Q9NPE2-2 ]
GeneIDi 51335.
KEGGi hsa:51335.
UCSCi uc002bpf.1. human. [Q9NPE2-2 ]

Organism-specific databases

CTDi 51335.
GeneCardsi GC15P090808.
H-InvDB HIX0012575.
HIX0172837.
HGNCi HGNC:18077. NGRN.
HPAi HPA041367.
neXtProti NX_Q9NPE2.
PharmGKBi PA142671265.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG76499.
HOGENOMi HOG000252993.
HOVERGENi HBG108182.
InParanoidi Q9NPE2.
OMAi TNTPRRQ.
OrthoDBi EOG7QC7W1.
PhylomeDBi Q9NPE2.
TreeFami TF324463.

Miscellaneous databases

GenomeRNAii 51335.
NextBioi 54759.
PROi Q9NPE2.

Gene expression databases

Bgeei Q9NPE2.
CleanExi HS_NGRN.
Genevestigatori Q9NPE2.

Family and domain databases

InterProi IPR010487. Neugrin-related.
[Graphical view ]
Pfami PF06413. Neugrin. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Two novel genes, human neugrin and mouse m-neugrin, are upregulated with neuronal differentiation in neuroblastoma cells."
    Ishigaki S., Niwa J., Yoshihara T., Mitsuma N., Doyu M., Sobue G.
    Biochem. Biophys. Res. Commun. 279:526-533(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  2. "cDNA DSC92 expressed by osteogenic human mesenchymal stem cells."
    van den Bos C., Mbalaviele G., Thiede M.
    Submitted (MAR-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    Tissue: Mesenchymal stem cell.
  3. The European IMAGE consortium
    Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Kidney.
  5. "Analysis of the DNA sequence and duplication history of human chromosome 15."
    Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K., Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N., Abouelleil A.
    , Arachchi H.M., Baradarani L., Birditt B., Bloom S., Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K., DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J., Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E., Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B., Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R., O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M.B., Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S., Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C.
    Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Brain, Chondrosarcoma, Lung, Muscle, Placenta and Testis.
  7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 20-291 (ISOFORM 2).
  8. Hu X., Xu Y., Peng X., Yuan J., Qiang B.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 73-291 (ISOFORM 1).
  9. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: PARTIAL NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Neuroblastoma.
  10. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  11. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-41, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.

Entry informationi

Entry nameiNGRN_HUMAN
AccessioniPrimary (citable) accession number: Q9NPE2
Secondary accession number(s): B2R6M8, Q4V9L7, Q9HBL4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: October 5, 2010
Last modified: July 9, 2014
This is version 116 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi