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Q9NPD7

- NRN1_HUMAN

UniProt

Q9NPD7 - NRN1_HUMAN

Protein

Neuritin

Gene

NRN1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Promotes neurite outgrowth and especially branching of neuritic processes in primary hippocampal and cortical cells.By similarity

    GO - Biological processi

    1. nervous system development Source: InterPro

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Neuritin
    Gene namesi
    Name:NRN1
    Synonyms:NRN
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 6

    Organism-specific databases

    HGNCiHGNC:17972. NRN1.

    Subcellular locationi

    Cell membrane Curated; Lipid-anchorGPI-anchor Curated. Cell junctionsynapse By similarity

    GO - Cellular componenti

    1. alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex Source: Ensembl
    2. anchored component of membrane Source: UniProtKB-KW
    3. cell junction Source: UniProtKB-KW
    4. synapse Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell junction, Cell membrane, Membrane, Synapse

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA38477.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2727Sequence AnalysisAdd
    BLAST
    Chaini28 – 11689NeuritinPRO_0000262512Add
    BLAST
    Propeptidei117 – 14226Removed in mature formSequence AnalysisPRO_0000262513Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Lipidationi116 – 1161GPI-anchor amidated glycineSequence Analysis

    Keywords - PTMi

    Glycoprotein, GPI-anchor, Lipoprotein

    Proteomic databases

    PaxDbiQ9NPD7.
    PeptideAtlasiQ9NPD7.
    PRIDEiQ9NPD7.

    Expressioni

    Gene expression databases

    BgeeiQ9NPD7.
    CleanExiHS_NRN1.
    GenevestigatoriQ9NPD7.

    Interactioni

    Subunit structurei

    Component of the outer core of AMPAR complex. AMPAR complex consists of an inner core made of 4 pore-forming GluA/GRIA proteins (GRIA1, GRIA2, GRIA3 and GRIA4) and 4 major auxiliary subunits arranged in a twofold symmetry. One of the two pairs of distinct binding sites is occupied either by CNIH2, CNIH3 or CACNG2, CACNG3. The other harbors CACNG2, CACNG3, CACNG4, CACNG8 or GSG1L. This inner core of AMPAR complex is complemented by outer core constituents binding directly to the GluA/GRIA proteins at sites distinct from the interaction sites of the inner core constituents. Outer core constituents include at least PRRT1, PRRT2, CKAMP44/SHISA9, FRRS1L and NRN1. The proteins of the inner and outer core serve as a platform for other, more peripherally associated AMPAR constituents. Alone or in combination, these auxiliary subunits control the gating and pharmacology of the AMPAR complex and profoundly impact their biogenesis and protein processing By similarity.By similarity

    Protein-protein interaction databases

    BioGridi119450. 1 interaction.
    STRINGi9606.ENSP00000244766.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9NPD7.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the neuritin family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG25834.
    HOGENOMiHOG000059601.
    HOVERGENiHBG052772.
    InParanoidiQ9NPD7.
    OMAiDNMANYP.
    OrthoDBiEOG7DJSP1.
    PhylomeDBiQ9NPD7.
    TreeFamiTF332589.

    Family and domain databases

    InterProiIPR026144. Neuritin_fam.
    [Graphical view]
    PANTHERiPTHR15902. PTHR15902. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9NPD7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGLKLNGRYI SLILAVQIAY LVQAVRAAGK CDAVFKGFSD CLLKLGDSMA    50
    NYPQGLDDKT NIKTVCTYWE DFHSCTVTAL TDCQEGAKDM WDKLRKESKN 100
    LNIQGSLFEL CGSGNGAAGS LLPAFPVLLV SLSAALATWL SF 142
    Length:142
    Mass (Da):15,333
    Last modified:October 1, 2000 - v1
    Checksum:i6C3C3DAC8D6392E6
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti48 – 492SM → TW in AAP97232. 1 PublicationCurated
    Sequence conflicti55 – 562GL → AW in AAP97232. 1 PublicationCurated
    Sequence conflicti113 – 1153SGN → RAT in AAP97232. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF136631 mRNA. Translation: AAF62371.1.
    AF114833 mRNA. Translation: AAP97232.1.
    AL136307 Genomic DNA. Translation: CAC00777.1.
    AK314095 mRNA. Translation: BAG36790.1.
    CH471087 Genomic DNA. Translation: EAW55184.1.
    BC002683 mRNA. Translation: AAH02683.1.
    BC042019 mRNA. Translation: AAH42019.1.
    CCDSiCCDS4495.1.
    RefSeqiNP_001265639.1. NM_001278710.1.
    NP_001265640.1. NM_001278711.1.
    NP_057672.1. NM_016588.2.
    UniGeneiHs.103291.

    Genome annotation databases

    EnsembliENST00000244766; ENSP00000244766; ENSG00000124785.
    GeneIDi51299.
    KEGGihsa:51299.
    UCSCiuc003mwu.3. human.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF136631 mRNA. Translation: AAF62371.1 .
    AF114833 mRNA. Translation: AAP97232.1 .
    AL136307 Genomic DNA. Translation: CAC00777.1 .
    AK314095 mRNA. Translation: BAG36790.1 .
    CH471087 Genomic DNA. Translation: EAW55184.1 .
    BC002683 mRNA. Translation: AAH02683.1 .
    BC042019 mRNA. Translation: AAH42019.1 .
    CCDSi CCDS4495.1.
    RefSeqi NP_001265639.1. NM_001278710.1.
    NP_001265640.1. NM_001278711.1.
    NP_057672.1. NM_016588.2.
    UniGenei Hs.103291.

    3D structure databases

    ProteinModelPortali Q9NPD7.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 119450. 1 interaction.
    STRINGi 9606.ENSP00000244766.

    Proteomic databases

    PaxDbi Q9NPD7.
    PeptideAtlasi Q9NPD7.
    PRIDEi Q9NPD7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000244766 ; ENSP00000244766 ; ENSG00000124785 .
    GeneIDi 51299.
    KEGGi hsa:51299.
    UCSCi uc003mwu.3. human.

    Organism-specific databases

    CTDi 51299.
    GeneCardsi GC06M005943.
    HGNCi HGNC:17972. NRN1.
    MIMi 607409. gene.
    neXtProti NX_Q9NPD7.
    PharmGKBi PA38477.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG25834.
    HOGENOMi HOG000059601.
    HOVERGENi HBG052772.
    InParanoidi Q9NPD7.
    OMAi DNMANYP.
    OrthoDBi EOG7DJSP1.
    PhylomeDBi Q9NPD7.
    TreeFami TF332589.

    Miscellaneous databases

    ChiTaRSi NRN1. human.
    GenomeRNAii 51299.
    NextBioi 54593.
    PROi Q9NPD7.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9NPD7.
    CleanExi HS_NRN1.
    Genevestigatori Q9NPD7.

    Family and domain databases

    InterProi IPR026144. Neuritin_fam.
    [Graphical view ]
    PANTHERi PTHR15902. PTHR15902. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Neuritin: a gene induced by neural activity and neurotrophins that promotes neuritogenesis."
      Naeve G.S., Ramakrishnan M., Kramer R., Hevroni D., Citri Y., Theill L.E.
      Proc. Natl. Acad. Sci. U.S.A. 94:2648-2653(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Adrenal cortex.
    2. "Isolation and cloning of a novel human cDNA encoding rat neuritin homolog."
      Zhou H., Huang X., Zhou Y., Hu S., Tang X., Yuan J., Qiang B.
      Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. "Cloning of a novel human cDNA homologous to Rattus norvegicus neuritin mRNA."
      Fan Y.X., Yu L., Zhang X.N., Xin Y.R., Wang X.K., Zhao S.Y.
      Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Pericardium.
    5. "The DNA sequence and analysis of human chromosome 6."
      Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
      , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
      Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain and Uterus.

    Entry informationi

    Entry nameiNRN1_HUMAN
    AccessioniPrimary (citable) accession number: Q9NPD7
    Secondary accession number(s): B2RA93, Q7Z4Y1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 28, 2006
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 90 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 6
      Human chromosome 6: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3