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Protein

Neuritin

Gene

NRN1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Promotes neurite outgrowth and especially branching of neuritic processes in primary hippocampal and cortical cells.By similarity

GO - Biological processi

  1. nervous system development Source: InterPro
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Neuritin
Gene namesi
Name:NRN1
Synonyms:NRN
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 6

Organism-specific databases

HGNCiHGNC:17972. NRN1.

Subcellular locationi

Cell membrane Curated; Lipid-anchorGPI-anchor Curated. Cell junctionsynapse By similarity

GO - Cellular componenti

  1. anchored component of membrane Source: UniProtKB-KW
  2. cell junction Source: UniProtKB-KW
  3. plasma membrane Source: UniProtKB-SubCell
  4. synapse Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Synapse

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA38477.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2727Sequence AnalysisAdd
BLAST
Chaini28 – 11689NeuritinPRO_0000262512Add
BLAST
Propeptidei117 – 14226Removed in mature formSequence AnalysisPRO_0000262513Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi116 – 1161GPI-anchor amidated glycineSequence Analysis

Keywords - PTMi

Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

PaxDbiQ9NPD7.
PeptideAtlasiQ9NPD7.
PRIDEiQ9NPD7.

Expressioni

Gene expression databases

BgeeiQ9NPD7.
CleanExiHS_NRN1.
GenevestigatoriQ9NPD7.

Interactioni

Subunit structurei

Component of the outer core of AMPAR complex. AMPAR complex consists of an inner core made of 4 pore-forming GluA/GRIA proteins (GRIA1, GRIA2, GRIA3 and GRIA4) and 4 major auxiliary subunits arranged in a twofold symmetry. One of the two pairs of distinct binding sites is occupied either by CNIH2, CNIH3 or CACNG2, CACNG3. The other harbors CACNG2, CACNG3, CACNG4, CACNG8 or GSG1L. This inner core of AMPAR complex is complemented by outer core constituents binding directly to the GluA/GRIA proteins at sites distinct from the interaction sites of the inner core constituents. Outer core constituents include at least PRRT1, PRRT2, CKAMP44/SHISA9, FRRS1L and NRN1. The proteins of the inner and outer core serve as a platform for other, more peripherally associated AMPAR constituents. Alone or in combination, these auxiliary subunits control the gating and pharmacology of the AMPAR complex and profoundly impact their biogenesis and protein processing (By similarity).By similarity

Protein-protein interaction databases

BioGridi119450. 1 interaction.
STRINGi9606.ENSP00000244766.

Structurei

3D structure databases

ProteinModelPortaliQ9NPD7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the neuritin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG25834.
GeneTreeiENSGT00530000063853.
HOGENOMiHOG000059601.
HOVERGENiHBG052772.
InParanoidiQ9NPD7.
OMAiFHSCATT.
OrthoDBiEOG7DJSP1.
PhylomeDBiQ9NPD7.
TreeFamiTF332589.

Family and domain databases

InterProiIPR026144. Neuritin_fam.
[Graphical view]
PANTHERiPTHR15902. PTHR15902. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9NPD7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGLKLNGRYI SLILAVQIAY LVQAVRAAGK CDAVFKGFSD CLLKLGDSMA
60 70 80 90 100
NYPQGLDDKT NIKTVCTYWE DFHSCTVTAL TDCQEGAKDM WDKLRKESKN
110 120 130 140
LNIQGSLFEL CGSGNGAAGS LLPAFPVLLV SLSAALATWL SF
Length:142
Mass (Da):15,333
Last modified:October 1, 2000 - v1
Checksum:i6C3C3DAC8D6392E6
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti48 – 492SM → TW in AAP97232. 1 PublicationCurated
Sequence conflicti55 – 562GL → AW in AAP97232. 1 PublicationCurated
Sequence conflicti113 – 1153SGN → RAT in AAP97232. 1 PublicationCurated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF136631 mRNA. Translation: AAF62371.1.
AF114833 mRNA. Translation: AAP97232.1.
AL136307 Genomic DNA. Translation: CAC00777.1.
AK314095 mRNA. Translation: BAG36790.1.
CH471087 Genomic DNA. Translation: EAW55184.1.
BC002683 mRNA. Translation: AAH02683.1.
BC042019 mRNA. Translation: AAH42019.1.
CCDSiCCDS4495.1.
RefSeqiNP_001265639.1. NM_001278710.1.
NP_001265640.1. NM_001278711.1.
NP_057672.1. NM_016588.2.
UniGeneiHs.103291.

Genome annotation databases

EnsembliENST00000244766; ENSP00000244766; ENSG00000124785.
ENST00000616243; ENSP00000484055; ENSG00000124785.
GeneIDi51299.
KEGGihsa:51299.
UCSCiuc003mwu.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF136631 mRNA. Translation: AAF62371.1.
AF114833 mRNA. Translation: AAP97232.1.
AL136307 Genomic DNA. Translation: CAC00777.1.
AK314095 mRNA. Translation: BAG36790.1.
CH471087 Genomic DNA. Translation: EAW55184.1.
BC002683 mRNA. Translation: AAH02683.1.
BC042019 mRNA. Translation: AAH42019.1.
CCDSiCCDS4495.1.
RefSeqiNP_001265639.1. NM_001278710.1.
NP_001265640.1. NM_001278711.1.
NP_057672.1. NM_016588.2.
UniGeneiHs.103291.

3D structure databases

ProteinModelPortaliQ9NPD7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119450. 1 interaction.
STRINGi9606.ENSP00000244766.

Proteomic databases

PaxDbiQ9NPD7.
PeptideAtlasiQ9NPD7.
PRIDEiQ9NPD7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000244766; ENSP00000244766; ENSG00000124785.
ENST00000616243; ENSP00000484055; ENSG00000124785.
GeneIDi51299.
KEGGihsa:51299.
UCSCiuc003mwu.3. human.

Organism-specific databases

CTDi51299.
GeneCardsiGC06M005943.
HGNCiHGNC:17972. NRN1.
MIMi607409. gene.
neXtProtiNX_Q9NPD7.
PharmGKBiPA38477.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG25834.
GeneTreeiENSGT00530000063853.
HOGENOMiHOG000059601.
HOVERGENiHBG052772.
InParanoidiQ9NPD7.
OMAiFHSCATT.
OrthoDBiEOG7DJSP1.
PhylomeDBiQ9NPD7.
TreeFamiTF332589.

Miscellaneous databases

ChiTaRSiNRN1. human.
GenomeRNAii51299.
NextBioi54593.
PROiQ9NPD7.
SOURCEiSearch...

Gene expression databases

BgeeiQ9NPD7.
CleanExiHS_NRN1.
GenevestigatoriQ9NPD7.

Family and domain databases

InterProiIPR026144. Neuritin_fam.
[Graphical view]
PANTHERiPTHR15902. PTHR15902. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Neuritin: a gene induced by neural activity and neurotrophins that promotes neuritogenesis."
    Naeve G.S., Ramakrishnan M., Kramer R., Hevroni D., Citri Y., Theill L.E.
    Proc. Natl. Acad. Sci. U.S.A. 94:2648-2653(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Adrenal cortex.
  2. "Isolation and cloning of a novel human cDNA encoding rat neuritin homolog."
    Zhou H., Huang X., Zhou Y., Hu S., Tang X., Yuan J., Qiang B.
    Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "Cloning of a novel human cDNA homologous to Rattus norvegicus neuritin mRNA."
    Fan Y.X., Yu L., Zhang X.N., Xin Y.R., Wang X.K., Zhao S.Y.
    Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Pericardium.
  5. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain and Uterus.

Entry informationi

Entry nameiNRN1_HUMAN
AccessioniPrimary (citable) accession number: Q9NPD7
Secondary accession number(s): B2RA93, Q7Z4Y1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: October 1, 2000
Last modified: January 7, 2015
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.