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Q9NPD5

- SO1B3_HUMAN

UniProt

Q9NPD5 - SO1B3_HUMAN

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Protein
Solute carrier organic anion transporter family member 1B3
Gene
SLCO1B3, LST2, OATP1B3, OATP8,SLC21A8
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Mediates the Na+-independent uptake of organic anions such as 17-beta-glucuronosyl estradiol, taurocholate, triiodothyronine (T3), leukotriene C4, dehydroepiandrosterone sulfate (DHEAS), methotrexate and sulfobromophthalein (BSP). Involved in the clearance of bile acids and organic anions from the liver.1 Publication

GO - Molecular functioni

  1. organic anion transmembrane transporter activity Source: ProtInc

GO - Biological processi

  1. bile acid and bile salt transport Source: Reactome
  2. bile acid metabolic process Source: Reactome
  3. organic anion transport Source: ProtInc
  4. small molecule metabolic process Source: Reactome
  5. sodium-independent organic anion transport Source: Reactome
  6. transmembrane transport Source: Reactome
Complete GO annotation...

Keywords - Biological processi

Ion transport, Transport

Enzyme and pathway databases

ReactomeiREACT_11042. Recycling of bile acids and salts.
REACT_23988. Transport of organic anions.

Protein family/group databases

TCDBi2.A.60.1.12. the organo anion transporter (oat) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier organic anion transporter family member 1B3
Alternative name(s):
Liver-specific organic anion transporter 2
Short name:
LST-2
Organic anion transporter 8
Organic anion-transporting polypeptide 8
Short name:
OATP-8
Solute carrier family 21 member 8
Gene namesi
Name:SLCO1B3
Synonyms:LST2, OATP1B3, OATP8,SLC21A8
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 12

Organism-specific databases

HGNCiHGNC:10961. SLCO1B3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2828Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei29 – 4820Helical; Name=1; Reviewed prediction
Add
BLAST
Topological domaini49 – 6719Extracellular Reviewed prediction
Add
BLAST
Transmembranei68 – 8821Helical; Name=2; Reviewed prediction
Add
BLAST
Topological domaini89 – 946Cytoplasmic Reviewed prediction
Transmembranei95 – 11925Helical; Name=3; Reviewed prediction
Add
BLAST
Topological domaini120 – 16849Extracellular Reviewed prediction
Add
BLAST
Transmembranei169 – 19729Helical; Name=4; Reviewed prediction
Add
BLAST
Topological domaini198 – 21619Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei217 – 23721Helical; Name=5; Reviewed prediction
Add
BLAST
Topological domaini238 – 25518Extracellular Reviewed prediction
Add
BLAST
Transmembranei256 – 28025Helical; Name=6; Reviewed prediction
Add
BLAST
Topological domaini281 – 33151Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei332 – 35322Helical; Name=7; Reviewed prediction
Add
BLAST
Topological domaini354 – 37320Extracellular Reviewed prediction
Add
BLAST
Transmembranei374 – 39724Helical; Name=8; Reviewed prediction
Add
BLAST
Topological domaini398 – 4014Cytoplasmic Reviewed prediction
Transmembranei402 – 42524Helical; Name=9; Reviewed prediction
Add
BLAST
Topological domaini426 – 537112Extracellular Reviewed prediction
Add
BLAST
Transmembranei538 – 56023Helical; Name=10; Reviewed prediction
Add
BLAST
Topological domaini561 – 5699Cytoplasmic Reviewed prediction
Transmembranei570 – 59526Helical; Name=11; Reviewed prediction
Add
BLAST
Topological domaini596 – 62934Extracellular Reviewed prediction
Add
BLAST
Transmembranei630 – 64718Helical; Name=12; Reviewed prediction
Add
BLAST
Topological domaini648 – 69548Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. basolateral plasma membrane Source: UniProtKB-SubCell
  2. integral component of plasma membrane Source: ProtInc
  3. plasma membrane Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Involvement in diseasei

Hyperbilirubinemia, Rotor type (HBLRR) [MIM:237450]: An autosomal recessive form of primary conjugated hyperbilirubinemia. Affected individuals develop mild jaundice not associated with hemolysis shortly after birth or in childhood. They have delayed plasma clearance of the unconjugated anionic dye bromsulphthalein and prominent urinary excretion of coproporphyrin I. Hepatic pigmentation is normal.
Note: The disease is caused by mutations affecting the gene represented in this entry.1 Publication

Organism-specific databases

MIMi237450. phenotype.
Orphaneti3111. Rotor syndrome.
PharmGKBiPA35844.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 702702Solute carrier organic anion transporter family member 1B3
PRO_0000191053Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi134 – 1341N-linked (GlcNAc...) Reviewed prediction
Glycosylationi145 – 1451N-linked (GlcNAc...) Reviewed prediction
Glycosylationi151 – 1511N-linked (GlcNAc...) Reviewed prediction
Glycosylationi445 – 4451N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi459 ↔ 485 By similarity
Disulfide bondi463 ↔ 474 By similarity
Disulfide bondi465 ↔ 489 By similarity
Glycosylationi503 – 5031N-linked (GlcNAc...) Reviewed prediction
Glycosylationi516 – 5161N-linked (GlcNAc...) Reviewed prediction

Post-translational modificationi

N-glycosylated.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9NPD5.
PRIDEiQ9NPD5.

PTM databases

PhosphoSiteiQ9NPD5.

Expressioni

Tissue specificityi

Highly expressed in liver, in particular at the basolateral membrane of hepatocytes near the central vein. Not detected in other tissues. Highly expressed in some cancer cell lines derived from colon, pancreas, liver and gall bladder.

Gene expression databases

ArrayExpressiQ9NPD5.
BgeeiQ9NPD5.
CleanExiHS_SLCO1B3.
GenevestigatoriQ9NPD5.

Organism-specific databases

HPAiHPA004943.
HPA050892.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000261196.

Structurei

3D structure databases

ProteinModelPortaliQ9NPD5.
SMRiQ9NPD5. Positions 463-489.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini453 – 50856Kazal-like
Add
BLAST

Sequence similaritiesi

Contains 1 Kazal-like domain.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG322696.
HOGENOMiHOG000231269.
HOVERGENiHBG063896.
InParanoidiQ9NPD5.
KOiK05043.
OMAiSHIGAIT.
OrthoDBiEOG7GFB4C.
PhylomeDBiQ9NPD5.
TreeFamiTF317540.

Family and domain databases

InterProiIPR002350. Kazal_dom.
IPR020846. MFS_dom.
IPR016196. MFS_dom_general_subst_transpt.
IPR004156. OA_transporter.
[Graphical view]
PANTHERiPTHR11388. PTHR11388. 1 hit.
PfamiPF07648. Kazal_2. 1 hit.
PF03137. OATP. 1 hit.
[Graphical view]
SMARTiSM00280. KAZAL. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 5 hits.
TIGRFAMsiTIGR00805. oat. 1 hit.
PROSITEiPS51465. KAZAL_2. 1 hit.
PS50850. MFS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9NPD5-1 [UniParc]FASTAAdd to Basket

« Hide

MDQHQHLNKT AESASSEKKK TRRCNGFKMF LAALSFSYIA KALGGIIMKI    50
SITQIERRFD ISSSLAGLID GSFEIGNLLV IVFVSYFGSK LHRPKLIGIG 100
CLLMGTGSIL TSLPHFFMGY YRYSKETHIN PSENSTSSLS TCLINQTLSF 150
NGTSPEIVEK DCVKESGSHM WIYVFMGNML RGIGETPIVP LGISYIDDFA 200
KEGHSSLYLG SLNAIGMIGP VIGFALGSLF AKMYVDIGYV DLSTIRITPK 250
DSRWVGAWWL GFLVSGLFSI ISSIPFFFLP KNPNKPQKER KISLSLHVLK 300
TNDDRNQTAN LTNQGKNVTK NVTGFFQSLK SILTNPLYVI FLLLTLLQVS 350
SFIGSFTYVF KYMEQQYGQS ASHANFLLGI ITIPTVATGM FLGGFIIKKF 400
KLSLVGIAKF SFLTSMISFL FQLLYFPLIC ESKSVAGLTL TYDGNNSVAS 450
HVDVPLSYCN SECNCDESQW EPVCGNNGIT YLSPCLAGCK SSSGIKKHTV 500
FYNCSCVEVT GLQNRNYSAH LGECPRDNTC TRKFFIYVAI QVINSLFSAT 550
GGTTFILLTV KIVQPELKAL AMGFQSMVIR TLGGILAPIY FGALIDKTCM 600
KWSTNSCGAQ GACRIYNSVF FGRVYLGLSI ALRFPALVLY IVFIFAMKKK 650
FQGKDTKASD NERKVMDEAN LEFLNNGEHF VPSAGTDSKT CNLDMQDNAA 700
AN 702
Length:702
Mass (Da):77,403
Last modified:October 1, 2000 - v1
Checksum:i6D2AE371D782C7FB
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti112 – 1121S → A.
Corresponds to variant rs4149117 [ dbSNP | Ensembl ].
VAR_024645
Natural varianti233 – 2331M → I.
Corresponds to variant rs7311358 [ dbSNP | Ensembl ].
VAR_053672
Natural varianti256 – 2561G → A.
Corresponds to variant rs60140950 [ dbSNP | Ensembl ].
VAR_062150
Natural varianti292 – 2921I → M in a colorectal cancer sample; somatic mutation. 1 Publication
VAR_036410
Natural varianti560 – 5601V → A.
Corresponds to variant rs12299012 [ dbSNP | Ensembl ].
VAR_053673
Natural varianti647 – 6471M → L in a colorectal cancer sample; somatic mutation. 1 Publication
VAR_036411

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ400763
, AJ400764, AJ400765, AJ400766, AJ400767, AJ400768, AJ400769, AJ400770, AJ400771, AJ400772, AJ400773, AJ400774, AJ400775, AJ400776 Genomic DNA. Translation: CAB97008.1.
AJ251506 mRNA. Translation: CAB96997.1.
AF187815 mRNA. Translation: AAG43445.1.
CCDSiCCDS8684.1.
RefSeqiNP_062818.1. NM_019844.3.
UniGeneiHs.504966.

Genome annotation databases

EnsembliENST00000261196; ENSP00000261196; ENSG00000111700.
ENST00000381545; ENSP00000370956; ENSG00000111700.
GeneIDi28234.
KEGGihsa:28234.
UCSCiuc001rel.4. human.

Polymorphism databases

DMDMi27734563.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ400763
, AJ400764 , AJ400765 , AJ400766 , AJ400767 , AJ400768 , AJ400769 , AJ400770 , AJ400771 , AJ400772 , AJ400773 , AJ400774 , AJ400775 , AJ400776 Genomic DNA. Translation: CAB97008.1 .
AJ251506 mRNA. Translation: CAB96997.1 .
AF187815 mRNA. Translation: AAG43445.1 .
CCDSi CCDS8684.1.
RefSeqi NP_062818.1. NM_019844.3.
UniGenei Hs.504966.

3D structure databases

ProteinModelPortali Q9NPD5.
SMRi Q9NPD5. Positions 463-489.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000261196.

Chemistry

BindingDBi Q9NPD5.
ChEMBLi CHEMBL1743121.
GuidetoPHARMACOLOGYi 1221.

Protein family/group databases

TCDBi 2.A.60.1.12. the organo anion transporter (oat) family.

PTM databases

PhosphoSitei Q9NPD5.

Polymorphism databases

DMDMi 27734563.

Proteomic databases

PaxDbi Q9NPD5.
PRIDEi Q9NPD5.

Protocols and materials databases

DNASUi 28234.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000261196 ; ENSP00000261196 ; ENSG00000111700 .
ENST00000381545 ; ENSP00000370956 ; ENSG00000111700 .
GeneIDi 28234.
KEGGi hsa:28234.
UCSCi uc001rel.4. human.

Organism-specific databases

CTDi 28234.
GeneCardsi GC12P020963.
GeneReviewsi SLCO1B3.
HGNCi HGNC:10961. SLCO1B3.
HPAi HPA004943.
HPA050892.
MIMi 237450. phenotype.
605495. gene.
neXtProti NX_Q9NPD5.
Orphaneti 3111. Rotor syndrome.
PharmGKBi PA35844.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG322696.
HOGENOMi HOG000231269.
HOVERGENi HBG063896.
InParanoidi Q9NPD5.
KOi K05043.
OMAi SHIGAIT.
OrthoDBi EOG7GFB4C.
PhylomeDBi Q9NPD5.
TreeFami TF317540.

Enzyme and pathway databases

Reactomei REACT_11042. Recycling of bile acids and salts.
REACT_23988. Transport of organic anions.

Miscellaneous databases

GeneWikii SLCO1B3.
GenomeRNAii 28234.
NextBioi 50556.
PROi Q9NPD5.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9NPD5.
Bgeei Q9NPD5.
CleanExi HS_SLCO1B3.
Genevestigatori Q9NPD5.

Family and domain databases

InterProi IPR002350. Kazal_dom.
IPR020846. MFS_dom.
IPR016196. MFS_dom_general_subst_transpt.
IPR004156. OA_transporter.
[Graphical view ]
PANTHERi PTHR11388. PTHR11388. 1 hit.
Pfami PF07648. Kazal_2. 1 hit.
PF03137. OATP. 1 hit.
[Graphical view ]
SMARTi SM00280. KAZAL. 1 hit.
[Graphical view ]
SUPFAMi SSF103473. SSF103473. 5 hits.
TIGRFAMsi TIGR00805. oat. 1 hit.
PROSITEi PS51465. KAZAL_2. 1 hit.
PS50850. MFS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Localization and genomic organization of a new hepatocellular organic anion transporting polypeptide."
    Koenig J., Cui Y., Nies A.T., Keppler D.
    J. Biol. Chem. 275:23161-23168(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], GLYCOSYLATION.
    Tissue: Liver.
  2. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Liver.
  3. "Complete OATP1B1 and OATP1B3 deficiency causes human Rotor syndrome by interrupting conjugated bilirubin reuptake into the liver."
    van de Steeg E., Stranecky V., Hartmannova H., Noskova L., Hrebicek M., Wagenaar E., van Esch A., de Waart D.R., Oude Elferink R.P., Kenworthy K.E., Sticova E., al-Edreesi M., Knisely A.S., Kmoch S., Jirsa M., Schinkel A.H.
    J. Clin. Invest. 122:519-528(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INVOLVEMENT IN HBLRR.
  4. Cited for: VARIANTS [LARGE SCALE ANALYSIS] MET-292 AND LEU-647.

Entry informationi

Entry nameiSO1B3_HUMAN
AccessioniPrimary (citable) accession number: Q9NPD5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 10, 2003
Last sequence update: October 1, 2000
Last modified: September 3, 2014
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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