Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q9NPD5

- SO1B3_HUMAN

UniProt

Q9NPD5 - SO1B3_HUMAN

Protein

Solute carrier organic anion transporter family member 1B3

Gene

SLCO1B3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 121 (01 Oct 2014)
      Sequence version 1 (01 Oct 2000)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Mediates the Na+-independent uptake of organic anions such as 17-beta-glucuronosyl estradiol, taurocholate, triiodothyronine (T3), leukotriene C4, dehydroepiandrosterone sulfate (DHEAS), methotrexate and sulfobromophthalein (BSP). Involved in the clearance of bile acids and organic anions from the liver.1 Publication

    GO - Molecular functioni

    1. organic anion transmembrane transporter activity Source: ProtInc

    GO - Biological processi

    1. bile acid and bile salt transport Source: Reactome
    2. bile acid metabolic process Source: Reactome
    3. organic anion transport Source: ProtInc
    4. small molecule metabolic process Source: Reactome
    5. sodium-independent organic anion transport Source: Reactome
    6. transmembrane transport Source: Reactome

    Keywords - Biological processi

    Ion transport, Transport

    Enzyme and pathway databases

    ReactomeiREACT_11042. Recycling of bile acids and salts.
    REACT_23988. Transport of organic anions.

    Protein family/group databases

    TCDBi2.A.60.1.12. the organo anion transporter (oat) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Solute carrier organic anion transporter family member 1B3
    Alternative name(s):
    Liver-specific organic anion transporter 2
    Short name:
    LST-2
    Organic anion transporter 8
    Organic anion-transporting polypeptide 8
    Short name:
    OATP-8
    Solute carrier family 21 member 8
    Gene namesi
    Name:SLCO1B3
    Synonyms:LST2, OATP1B3, OATP8,SLC21A8
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 12

    Organism-specific databases

    HGNCiHGNC:10961. SLCO1B3.

    Subcellular locationi

    GO - Cellular componenti

    1. basolateral plasma membrane Source: UniProtKB-SubCell
    2. integral component of plasma membrane Source: ProtInc
    3. plasma membrane Source: HPA

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Involvement in diseasei

    Hyperbilirubinemia, Rotor type (HBLRR) [MIM:237450]: An autosomal recessive form of primary conjugated hyperbilirubinemia. Affected individuals develop mild jaundice not associated with hemolysis shortly after birth or in childhood. They have delayed plasma clearance of the unconjugated anionic dye bromsulphthalein and prominent urinary excretion of coproporphyrin I. Hepatic pigmentation is normal.1 Publication
    Note: The disease is caused by mutations affecting the gene represented in this entry.

    Organism-specific databases

    MIMi237450. phenotype.
    Orphaneti3111. Rotor syndrome.
    PharmGKBiPA35844.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 702702Solute carrier organic anion transporter family member 1B3PRO_0000191053Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi134 – 1341N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi145 – 1451N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi151 – 1511N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi445 – 4451N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi459 ↔ 485PROSITE-ProRule annotation
    Disulfide bondi463 ↔ 474PROSITE-ProRule annotation
    Disulfide bondi465 ↔ 489PROSITE-ProRule annotation
    Glycosylationi503 – 5031N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi516 – 5161N-linked (GlcNAc...)Sequence Analysis

    Post-translational modificationi

    N-glycosylated.1 Publication

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ9NPD5.
    PRIDEiQ9NPD5.

    PTM databases

    PhosphoSiteiQ9NPD5.

    Expressioni

    Tissue specificityi

    Highly expressed in liver, in particular at the basolateral membrane of hepatocytes near the central vein. Not detected in other tissues. Highly expressed in some cancer cell lines derived from colon, pancreas, liver and gall bladder.

    Gene expression databases

    ArrayExpressiQ9NPD5.
    BgeeiQ9NPD5.
    CleanExiHS_SLCO1B3.
    GenevestigatoriQ9NPD5.

    Organism-specific databases

    HPAiHPA004943.
    HPA050892.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000261196.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9NPD5.
    SMRiQ9NPD5. Positions 463-489.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2828CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini49 – 6719ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini89 – 946CytoplasmicSequence Analysis
    Topological domaini120 – 16849ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini198 – 21619CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini238 – 25518ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini281 – 33151CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini354 – 37320ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini398 – 4014CytoplasmicSequence Analysis
    Topological domaini426 – 537112ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini561 – 5699CytoplasmicSequence Analysis
    Topological domaini596 – 62934ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini648 – 69548CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei29 – 4820Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei68 – 8821Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei95 – 11925Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei169 – 19729Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei217 – 23721Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei256 – 28025Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei332 – 35322Helical; Name=7Sequence AnalysisAdd
    BLAST
    Transmembranei374 – 39724Helical; Name=8Sequence AnalysisAdd
    BLAST
    Transmembranei402 – 42524Helical; Name=9Sequence AnalysisAdd
    BLAST
    Transmembranei538 – 56023Helical; Name=10Sequence AnalysisAdd
    BLAST
    Transmembranei570 – 59526Helical; Name=11Sequence AnalysisAdd
    BLAST
    Transmembranei630 – 64718Helical; Name=12Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini453 – 50856Kazal-likePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 Kazal-like domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG322696.
    HOGENOMiHOG000231269.
    HOVERGENiHBG063896.
    InParanoidiQ9NPD5.
    KOiK05043.
    OMAiSHIGAIT.
    OrthoDBiEOG7GFB4C.
    PhylomeDBiQ9NPD5.
    TreeFamiTF317540.

    Family and domain databases

    InterProiIPR002350. Kazal_dom.
    IPR020846. MFS_dom.
    IPR016196. MFS_dom_general_subst_transpt.
    IPR004156. OA_transporter.
    [Graphical view]
    PANTHERiPTHR11388. PTHR11388. 1 hit.
    PfamiPF07648. Kazal_2. 1 hit.
    PF03137. OATP. 1 hit.
    [Graphical view]
    SMARTiSM00280. KAZAL. 1 hit.
    [Graphical view]
    SUPFAMiSSF103473. SSF103473. 5 hits.
    TIGRFAMsiTIGR00805. oat. 1 hit.
    PROSITEiPS51465. KAZAL_2. 1 hit.
    PS50850. MFS. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9NPD5-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MDQHQHLNKT AESASSEKKK TRRCNGFKMF LAALSFSYIA KALGGIIMKI    50
    SITQIERRFD ISSSLAGLID GSFEIGNLLV IVFVSYFGSK LHRPKLIGIG 100
    CLLMGTGSIL TSLPHFFMGY YRYSKETHIN PSENSTSSLS TCLINQTLSF 150
    NGTSPEIVEK DCVKESGSHM WIYVFMGNML RGIGETPIVP LGISYIDDFA 200
    KEGHSSLYLG SLNAIGMIGP VIGFALGSLF AKMYVDIGYV DLSTIRITPK 250
    DSRWVGAWWL GFLVSGLFSI ISSIPFFFLP KNPNKPQKER KISLSLHVLK 300
    TNDDRNQTAN LTNQGKNVTK NVTGFFQSLK SILTNPLYVI FLLLTLLQVS 350
    SFIGSFTYVF KYMEQQYGQS ASHANFLLGI ITIPTVATGM FLGGFIIKKF 400
    KLSLVGIAKF SFLTSMISFL FQLLYFPLIC ESKSVAGLTL TYDGNNSVAS 450
    HVDVPLSYCN SECNCDESQW EPVCGNNGIT YLSPCLAGCK SSSGIKKHTV 500
    FYNCSCVEVT GLQNRNYSAH LGECPRDNTC TRKFFIYVAI QVINSLFSAT 550
    GGTTFILLTV KIVQPELKAL AMGFQSMVIR TLGGILAPIY FGALIDKTCM 600
    KWSTNSCGAQ GACRIYNSVF FGRVYLGLSI ALRFPALVLY IVFIFAMKKK 650
    FQGKDTKASD NERKVMDEAN LEFLNNGEHF VPSAGTDSKT CNLDMQDNAA 700
    AN 702
    Length:702
    Mass (Da):77,403
    Last modified:October 1, 2000 - v1
    Checksum:i6D2AE371D782C7FB
    GO
    Isoform 2 (identifier: Q9NPD5-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         622-664: GRVYLGLSIA...DTKASDNERK → GIVQPELKAL...DTKVLENERQ
         676-677: NG → DS
         685-702: GTDSKTCNLDMQDNAAAN → EEQ

    Show »
    Length:748
    Mass (Da):82,544
    Checksum:i09A644194BDE3B85
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti112 – 1121S → A.
    Corresponds to variant rs4149117 [ dbSNP | Ensembl ].
    VAR_024645
    Natural varianti233 – 2331M → I.
    Corresponds to variant rs7311358 [ dbSNP | Ensembl ].
    VAR_053672
    Natural varianti256 – 2561G → A.
    Corresponds to variant rs60140950 [ dbSNP | Ensembl ].
    VAR_062150
    Natural varianti292 – 2921I → M in a colorectal cancer sample; somatic mutation. 1 Publication
    VAR_036410
    Natural varianti560 – 5601V → A.
    Corresponds to variant rs12299012 [ dbSNP | Ensembl ].
    VAR_053673
    Natural varianti647 – 6471M → L in a colorectal cancer sample; somatic mutation. 1 Publication
    VAR_036411

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei622 – 66443GRVYL…DNERK → GIVQPELKALAIGFHSMIMR SLGGILVPIYFGALIDTTCM KWSTNSCGARGACRIYNSTY LGRAFFGLKVALIFPVLVLL TVFIFVVRKKSHGKDTKVLE NERQ in isoform 2. 1 PublicationVSP_056615Add
    BLAST
    Alternative sequencei676 – 6772NG → DS in isoform 2. 1 PublicationVSP_056616
    Alternative sequencei685 – 70218GTDSK…NAAAN → EEQ in isoform 2. 1 PublicationVSP_056617Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ400763
    , AJ400764, AJ400765, AJ400766, AJ400767, AJ400768, AJ400769, AJ400770, AJ400771, AJ400772, AJ400773, AJ400774, AJ400775, AJ400776 Genomic DNA. Translation: CAB97008.1.
    AJ251506 mRNA. Translation: CAB96997.1.
    AF187815 mRNA. Translation: AAG43445.1.
    AY257471 mRNA. Translation: AAP81212.1.
    AY442326 mRNA. Translation: AAS01768.1.
    AC011604 Genomic DNA. No translation available.
    AC087309 Genomic DNA. No translation available.
    CCDSiCCDS8684.1.
    RefSeqiNP_062818.1. NM_019844.3.
    UniGeneiHs.504966.

    Genome annotation databases

    EnsembliENST00000261196; ENSP00000261196; ENSG00000111700.
    ENST00000381545; ENSP00000370956; ENSG00000111700.
    ENST00000540229; ENSP00000441269; ENSG00000257046.
    GeneIDi28234.
    KEGGihsa:28234.
    UCSCiuc001rel.4. human.

    Polymorphism databases

    DMDMi27734563.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ400763
    , AJ400764 , AJ400765 , AJ400766 , AJ400767 , AJ400768 , AJ400769 , AJ400770 , AJ400771 , AJ400772 , AJ400773 , AJ400774 , AJ400775 , AJ400776 Genomic DNA. Translation: CAB97008.1 .
    AJ251506 mRNA. Translation: CAB96997.1 .
    AF187815 mRNA. Translation: AAG43445.1 .
    AY257471 mRNA. Translation: AAP81212.1 .
    AY442326 mRNA. Translation: AAS01768.1 .
    AC011604 Genomic DNA. No translation available.
    AC087309 Genomic DNA. No translation available.
    CCDSi CCDS8684.1.
    RefSeqi NP_062818.1. NM_019844.3.
    UniGenei Hs.504966.

    3D structure databases

    ProteinModelPortali Q9NPD5.
    SMRi Q9NPD5. Positions 463-489.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000261196.

    Chemistry

    BindingDBi Q9NPD5.
    ChEMBLi CHEMBL1743121.
    GuidetoPHARMACOLOGYi 1221.

    Protein family/group databases

    TCDBi 2.A.60.1.12. the organo anion transporter (oat) family.

    PTM databases

    PhosphoSitei Q9NPD5.

    Polymorphism databases

    DMDMi 27734563.

    Proteomic databases

    PaxDbi Q9NPD5.
    PRIDEi Q9NPD5.

    Protocols and materials databases

    DNASUi 28234.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000261196 ; ENSP00000261196 ; ENSG00000111700 .
    ENST00000381545 ; ENSP00000370956 ; ENSG00000111700 .
    ENST00000540229 ; ENSP00000441269 ; ENSG00000257046 .
    GeneIDi 28234.
    KEGGi hsa:28234.
    UCSCi uc001rel.4. human.

    Organism-specific databases

    CTDi 28234.
    GeneCardsi GC12P020963.
    GeneReviewsi SLCO1B3.
    HGNCi HGNC:10961. SLCO1B3.
    HPAi HPA004943.
    HPA050892.
    MIMi 237450. phenotype.
    605495. gene.
    neXtProti NX_Q9NPD5.
    Orphaneti 3111. Rotor syndrome.
    PharmGKBi PA35844.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG322696.
    HOGENOMi HOG000231269.
    HOVERGENi HBG063896.
    InParanoidi Q9NPD5.
    KOi K05043.
    OMAi SHIGAIT.
    OrthoDBi EOG7GFB4C.
    PhylomeDBi Q9NPD5.
    TreeFami TF317540.

    Enzyme and pathway databases

    Reactomei REACT_11042. Recycling of bile acids and salts.
    REACT_23988. Transport of organic anions.

    Miscellaneous databases

    GeneWikii SLCO1B3.
    GenomeRNAii 28234.
    NextBioi 50556.
    PROi Q9NPD5.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9NPD5.
    Bgeei Q9NPD5.
    CleanExi HS_SLCO1B3.
    Genevestigatori Q9NPD5.

    Family and domain databases

    InterProi IPR002350. Kazal_dom.
    IPR020846. MFS_dom.
    IPR016196. MFS_dom_general_subst_transpt.
    IPR004156. OA_transporter.
    [Graphical view ]
    PANTHERi PTHR11388. PTHR11388. 1 hit.
    Pfami PF07648. Kazal_2. 1 hit.
    PF03137. OATP. 1 hit.
    [Graphical view ]
    SMARTi SM00280. KAZAL. 1 hit.
    [Graphical view ]
    SUPFAMi SSF103473. SSF103473. 5 hits.
    TIGRFAMsi TIGR00805. oat. 1 hit.
    PROSITEi PS51465. KAZAL_2. 1 hit.
    PS50850. MFS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Localization and genomic organization of a new hepatocellular organic anion transporting polypeptide."
      Koenig J., Cui Y., Nies A.T., Keppler D.
      J. Biol. Chem. 275:23161-23168(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1), GLYCOSYLATION.
      Tissue: Liver.
    2. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Liver.
    3. "Molecular identification of LST-3 subtype."
      Mizutamari H., Abe T.
      Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    4. "The finished DNA sequence of human chromosome 12."
      Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.
      , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A.
      Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "Complete OATP1B1 and OATP1B3 deficiency causes human Rotor syndrome by interrupting conjugated bilirubin reuptake into the liver."
      van de Steeg E., Stranecky V., Hartmannova H., Noskova L., Hrebicek M., Wagenaar E., van Esch A., de Waart D.R., Oude Elferink R.P., Kenworthy K.E., Sticova E., al-Edreesi M., Knisely A.S., Kmoch S., Jirsa M., Schinkel A.H.
      J. Clin. Invest. 122:519-528(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INVOLVEMENT IN HBLRR.
    6. Cited for: VARIANTS [LARGE SCALE ANALYSIS] MET-292 AND LEU-647.

    Entry informationi

    Entry nameiSO1B3_HUMAN
    AccessioniPrimary (citable) accession number: Q9NPD5
    Secondary accession number(s): E7EMT8, Q5JAR4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 10, 2003
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 121 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 12
      Human chromosome 12: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3