Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Solute carrier organic anion transporter family member 1B3

Gene

SLCO1B3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Mediates the Na+-independent uptake of organic anions such as 17-beta-glucuronosyl estradiol, taurocholate, triiodothyronine (T3), leukotriene C4, dehydroepiandrosterone sulfate (DHEAS), methotrexate and sulfobromophthalein (BSP). Involved in the clearance of bile acids and organic anions from the liver.1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Ion transport, Transport

Enzyme and pathway databases

BioCyciZFISH:ENSG00000111700-MONOMER.
ReactomeiR-HSA-159418. Recycling of bile acids and salts.
R-HSA-879518. Transport of organic anions.

Protein family/group databases

TCDBi2.A.60.1.12. the organo anion transporter (oat) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier organic anion transporter family member 1B3
Alternative name(s):
Liver-specific organic anion transporter 2
Short name:
LST-2
Organic anion transporter 8
Organic anion-transporting polypeptide 8
Short name:
OATP-8
Solute carrier family 21 member 8
Gene namesi
Name:SLCO1B3
Synonyms:LST2, OATP1B3, OATP8, SLC21A8
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:10961. SLCO1B3.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 28CytoplasmicSequence analysisAdd BLAST28
Transmembranei29 – 48Helical; Name=1Sequence analysisAdd BLAST20
Topological domaini49 – 67ExtracellularSequence analysisAdd BLAST19
Transmembranei68 – 88Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini89 – 94CytoplasmicSequence analysis6
Transmembranei95 – 119Helical; Name=3Sequence analysisAdd BLAST25
Topological domaini120 – 168ExtracellularSequence analysisAdd BLAST49
Transmembranei169 – 197Helical; Name=4Sequence analysisAdd BLAST29
Topological domaini198 – 216CytoplasmicSequence analysisAdd BLAST19
Transmembranei217 – 237Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini238 – 255ExtracellularSequence analysisAdd BLAST18
Transmembranei256 – 280Helical; Name=6Sequence analysisAdd BLAST25
Topological domaini281 – 331CytoplasmicSequence analysisAdd BLAST51
Transmembranei332 – 353Helical; Name=7Sequence analysisAdd BLAST22
Topological domaini354 – 373ExtracellularSequence analysisAdd BLAST20
Transmembranei374 – 397Helical; Name=8Sequence analysisAdd BLAST24
Topological domaini398 – 401CytoplasmicSequence analysis4
Transmembranei402 – 425Helical; Name=9Sequence analysisAdd BLAST24
Topological domaini426 – 537ExtracellularSequence analysisAdd BLAST112
Transmembranei538 – 560Helical; Name=10Sequence analysisAdd BLAST23
Topological domaini561 – 569CytoplasmicSequence analysis9
Transmembranei570 – 595Helical; Name=11Sequence analysisAdd BLAST26
Topological domaini596 – 629ExtracellularSequence analysisAdd BLAST34
Transmembranei630 – 647Helical; Name=12Sequence analysisAdd BLAST18
Topological domaini648 – 695CytoplasmicSequence analysisAdd BLAST48

GO - Cellular componenti

  • basolateral plasma membrane Source: UniProtKB-SubCell
  • integral component of plasma membrane Source: ProtInc
  • plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Involvement in diseasei

Hyperbilirubinemia, Rotor type (HBLRR)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn autosomal recessive form of primary conjugated hyperbilirubinemia. Affected individuals develop mild jaundice not associated with hemolysis shortly after birth or in childhood. They have delayed plasma clearance of the unconjugated anionic dye bromsulphthalein and prominent urinary excretion of coproporphyrin I. Hepatic pigmentation is normal.
See also OMIM:237450

Organism-specific databases

DisGeNETi28234.
MalaCardsiSLCO1B3.
MIMi237450. phenotype.
OpenTargetsiENSG00000111700.
ENSG00000257046.
Orphaneti3111. Rotor syndrome.
PharmGKBiPA35844.

Chemistry databases

ChEMBLiCHEMBL1743121.
DrugBankiDB06403. Ambrisentan.
DB01076. Atorvastatin.
DB06772. Cabazitaxel.
DB00520. Caspofungin.
DB08862. Cholecystokinin.
DB02659. Cholic Acid.
DB01211. Clarithromycin.
DB05239. Cobimetinib.
DB00286. Conjugated Estrogens.
DB08912. Dabrafenib.
DB09102. Daclatasvir.
DB00390. Digoxin.
DB01248. Docetaxel.
DB00783. Estradiol.
DB00950. Fexofenadine.
DB01095. Fluvastatin.
DB08884. Gadoxetate.
DB09054. Idelalisib.
DB00451. Levothyroxine.
DB00279. Liothyronine.
DB01583. Liotrix.
DB00563. Methotrexate.
DB00688. Mycophenolate mofetil.
DB00275. Olmesartan.
DB01092. Ouabain.
DB01229. Paclitaxel.
DB01132. Pioglitazone.
DB08860. Pitavastatin.
DB00175. Pravastatin.
DB01045. Rifampicin.
DB08864. Rilpivirine.
DB06176. Romidepsin.
DB01098. Rosuvastatin.
DB09292. Sacubitril.
DB11362. Selexipag.
DB00177. Valsartan.
GuidetoPHARMACOLOGYi1221.

Polymorphism and mutation databases

BioMutaiSLCO1B3.
DMDMi27734563.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001910531 – 702Solute carrier organic anion transporter family member 1B3Add BLAST702

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi134N-linked (GlcNAc...)Sequence analysis1
Glycosylationi145N-linked (GlcNAc...)Sequence analysis1
Glycosylationi151N-linked (GlcNAc...)Sequence analysis1
Modified residuei293PhosphoserineBy similarity1
Modified residuei295PhosphoserineBy similarity1
Glycosylationi445N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi459 ↔ 485PROSITE-ProRule annotation
Disulfide bondi463 ↔ 474PROSITE-ProRule annotation
Disulfide bondi465 ↔ 489PROSITE-ProRule annotation
Glycosylationi503N-linked (GlcNAc...)Sequence analysis1
Glycosylationi516N-linked (GlcNAc...)Sequence analysis1
Modified residuei683PhosphoserineBy similarity1

Post-translational modificationi

N-glycosylated.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ9NPD5.
PeptideAtlasiQ9NPD5.
PRIDEiQ9NPD5.

PTM databases

iPTMnetiQ9NPD5.
PhosphoSitePlusiQ9NPD5.

Expressioni

Tissue specificityi

Highly expressed in liver, in particular at the basolateral membrane of hepatocytes near the central vein. Not detected in other tissues. Highly expressed in some cancer cell lines derived from colon, pancreas, liver and gall bladder.

Gene expression databases

BgeeiENSG00000111700.
CleanExiHS_SLCO1B3.
ExpressionAtlasiQ9NPD5. baseline and differential.
GenevisibleiQ9NPD5. HS.

Organism-specific databases

HPAiHPA004943.
HPA050892.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000261196.

Chemistry databases

BindingDBiQ9NPD5.

Structurei

3D structure databases

ProteinModelPortaliQ9NPD5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini453 – 508Kazal-likePROSITE-ProRule annotationAdd BLAST56

Sequence similaritiesi

Contains 1 Kazal-like domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3626. Eukaryota.
ENOG410XRSF. LUCA.
GeneTreeiENSGT00760000119014.
HOGENOMiHOG000231269.
HOVERGENiHBG063896.
InParanoidiQ9NPD5.
KOiK05043.
OMAiFLNNGEH.
OrthoDBiEOG091G08QD.
PhylomeDBiQ9NPD5.
TreeFamiTF317540.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR002350. Kazal_dom.
IPR020846. MFS_dom.
IPR004156. OA_transporter.
[Graphical view]
PANTHERiPTHR11388. PTHR11388. 1 hit.
PfamiPF07648. Kazal_2. 1 hit.
PF03137. OATP. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 5 hits.
TIGRFAMsiTIGR00805. oat. 1 hit.
PROSITEiPS51465. KAZAL_2. 1 hit.
PS50850. MFS. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9NPD5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDQHQHLNKT AESASSEKKK TRRCNGFKMF LAALSFSYIA KALGGIIMKI
60 70 80 90 100
SITQIERRFD ISSSLAGLID GSFEIGNLLV IVFVSYFGSK LHRPKLIGIG
110 120 130 140 150
CLLMGTGSIL TSLPHFFMGY YRYSKETHIN PSENSTSSLS TCLINQTLSF
160 170 180 190 200
NGTSPEIVEK DCVKESGSHM WIYVFMGNML RGIGETPIVP LGISYIDDFA
210 220 230 240 250
KEGHSSLYLG SLNAIGMIGP VIGFALGSLF AKMYVDIGYV DLSTIRITPK
260 270 280 290 300
DSRWVGAWWL GFLVSGLFSI ISSIPFFFLP KNPNKPQKER KISLSLHVLK
310 320 330 340 350
TNDDRNQTAN LTNQGKNVTK NVTGFFQSLK SILTNPLYVI FLLLTLLQVS
360 370 380 390 400
SFIGSFTYVF KYMEQQYGQS ASHANFLLGI ITIPTVATGM FLGGFIIKKF
410 420 430 440 450
KLSLVGIAKF SFLTSMISFL FQLLYFPLIC ESKSVAGLTL TYDGNNSVAS
460 470 480 490 500
HVDVPLSYCN SECNCDESQW EPVCGNNGIT YLSPCLAGCK SSSGIKKHTV
510 520 530 540 550
FYNCSCVEVT GLQNRNYSAH LGECPRDNTC TRKFFIYVAI QVINSLFSAT
560 570 580 590 600
GGTTFILLTV KIVQPELKAL AMGFQSMVIR TLGGILAPIY FGALIDKTCM
610 620 630 640 650
KWSTNSCGAQ GACRIYNSVF FGRVYLGLSI ALRFPALVLY IVFIFAMKKK
660 670 680 690 700
FQGKDTKASD NERKVMDEAN LEFLNNGEHF VPSAGTDSKT CNLDMQDNAA

AN
Length:702
Mass (Da):77,403
Last modified:October 1, 2000 - v1
Checksum:i6D2AE371D782C7FB
GO
Isoform 2 (identifier: Q9NPD5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     622-664: GRVYLGLSIA...DTKASDNERK → GIVQPELKAL...DTKVLENERQ
     676-677: NG → DS
     685-702: GTDSKTCNLDMQDNAAAN → EEQ

Show »
Length:748
Mass (Da):82,544
Checksum:i09A644194BDE3B85
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_024645112S → A.Corresponds to variant rs4149117dbSNPEnsembl.1
Natural variantiVAR_053672233M → I.Corresponds to variant rs7311358dbSNPEnsembl.1
Natural variantiVAR_062150256G → A.Corresponds to variant rs60140950dbSNPEnsembl.1
Natural variantiVAR_036410292I → M in a colorectal cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_053673560V → A.Corresponds to variant rs12299012dbSNPEnsembl.1
Natural variantiVAR_036411647M → L in a colorectal cancer sample; somatic mutation. 1 PublicationCorresponds to variant rs556554798dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_056615622 – 664GRVYL…DNERK → GIVQPELKALAIGFHSMIMR SLGGILVPIYFGALIDTTCM KWSTNSCGARGACRIYNSTY LGRAFFGLKVALIFPVLVLL TVFIFVVRKKSHGKDTKVLE NERQ in isoform 2. 1 PublicationAdd BLAST43
Alternative sequenceiVSP_056616676 – 677NG → DS in isoform 2. 1 Publication2
Alternative sequenceiVSP_056617685 – 702GTDSK…NAAAN → EEQ in isoform 2. 1 PublicationAdd BLAST18

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ400763
, AJ400764, AJ400765, AJ400766, AJ400767, AJ400768, AJ400769, AJ400770, AJ400771, AJ400772, AJ400773, AJ400774, AJ400775, AJ400776 Genomic DNA. Translation: CAB97008.1.
AJ251506 mRNA. Translation: CAB96997.1.
AF187815 mRNA. Translation: AAG43445.1.
AY257471 mRNA. Translation: AAP81212.1.
AY442326 mRNA. Translation: AAS01768.1.
AC011604 Genomic DNA. No translation available.
AC087309 Genomic DNA. No translation available.
CCDSiCCDS8684.1. [Q9NPD5-1]
RefSeqiNP_062818.1. NM_019844.3. [Q9NPD5-1]
UniGeneiHs.504966.

Genome annotation databases

EnsembliENST00000261196; ENSP00000261196; ENSG00000111700. [Q9NPD5-1]
ENST00000381545; ENSP00000370956; ENSG00000111700. [Q9NPD5-1]
GeneIDi28234.
KEGGihsa:28234.
UCSCiuc001rel.5. human. [Q9NPD5-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ400763
, AJ400764, AJ400765, AJ400766, AJ400767, AJ400768, AJ400769, AJ400770, AJ400771, AJ400772, AJ400773, AJ400774, AJ400775, AJ400776 Genomic DNA. Translation: CAB97008.1.
AJ251506 mRNA. Translation: CAB96997.1.
AF187815 mRNA. Translation: AAG43445.1.
AY257471 mRNA. Translation: AAP81212.1.
AY442326 mRNA. Translation: AAS01768.1.
AC011604 Genomic DNA. No translation available.
AC087309 Genomic DNA. No translation available.
CCDSiCCDS8684.1. [Q9NPD5-1]
RefSeqiNP_062818.1. NM_019844.3. [Q9NPD5-1]
UniGeneiHs.504966.

3D structure databases

ProteinModelPortaliQ9NPD5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000261196.

Chemistry databases

BindingDBiQ9NPD5.
ChEMBLiCHEMBL1743121.
DrugBankiDB06403. Ambrisentan.
DB01076. Atorvastatin.
DB06772. Cabazitaxel.
DB00520. Caspofungin.
DB08862. Cholecystokinin.
DB02659. Cholic Acid.
DB01211. Clarithromycin.
DB05239. Cobimetinib.
DB00286. Conjugated Estrogens.
DB08912. Dabrafenib.
DB09102. Daclatasvir.
DB00390. Digoxin.
DB01248. Docetaxel.
DB00783. Estradiol.
DB00950. Fexofenadine.
DB01095. Fluvastatin.
DB08884. Gadoxetate.
DB09054. Idelalisib.
DB00451. Levothyroxine.
DB00279. Liothyronine.
DB01583. Liotrix.
DB00563. Methotrexate.
DB00688. Mycophenolate mofetil.
DB00275. Olmesartan.
DB01092. Ouabain.
DB01229. Paclitaxel.
DB01132. Pioglitazone.
DB08860. Pitavastatin.
DB00175. Pravastatin.
DB01045. Rifampicin.
DB08864. Rilpivirine.
DB06176. Romidepsin.
DB01098. Rosuvastatin.
DB09292. Sacubitril.
DB11362. Selexipag.
DB00177. Valsartan.
GuidetoPHARMACOLOGYi1221.

Protein family/group databases

TCDBi2.A.60.1.12. the organo anion transporter (oat) family.

PTM databases

iPTMnetiQ9NPD5.
PhosphoSitePlusiQ9NPD5.

Polymorphism and mutation databases

BioMutaiSLCO1B3.
DMDMi27734563.

Proteomic databases

PaxDbiQ9NPD5.
PeptideAtlasiQ9NPD5.
PRIDEiQ9NPD5.

Protocols and materials databases

DNASUi28234.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000261196; ENSP00000261196; ENSG00000111700. [Q9NPD5-1]
ENST00000381545; ENSP00000370956; ENSG00000111700. [Q9NPD5-1]
GeneIDi28234.
KEGGihsa:28234.
UCSCiuc001rel.5. human. [Q9NPD5-1]

Organism-specific databases

CTDi28234.
DisGeNETi28234.
GeneCardsiSLCO1B3.
GeneReviewsiSLCO1B3.
HGNCiHGNC:10961. SLCO1B3.
HPAiHPA004943.
HPA050892.
MalaCardsiSLCO1B3.
MIMi237450. phenotype.
605495. gene.
neXtProtiNX_Q9NPD5.
OpenTargetsiENSG00000111700.
ENSG00000257046.
Orphaneti3111. Rotor syndrome.
PharmGKBiPA35844.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3626. Eukaryota.
ENOG410XRSF. LUCA.
GeneTreeiENSGT00760000119014.
HOGENOMiHOG000231269.
HOVERGENiHBG063896.
InParanoidiQ9NPD5.
KOiK05043.
OMAiFLNNGEH.
OrthoDBiEOG091G08QD.
PhylomeDBiQ9NPD5.
TreeFamiTF317540.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000111700-MONOMER.
ReactomeiR-HSA-159418. Recycling of bile acids and salts.
R-HSA-879518. Transport of organic anions.

Miscellaneous databases

GeneWikiiSLCO1B3.
GenomeRNAii28234.
PROiQ9NPD5.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000111700.
CleanExiHS_SLCO1B3.
ExpressionAtlasiQ9NPD5. baseline and differential.
GenevisibleiQ9NPD5. HS.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR002350. Kazal_dom.
IPR020846. MFS_dom.
IPR004156. OA_transporter.
[Graphical view]
PANTHERiPTHR11388. PTHR11388. 1 hit.
PfamiPF07648. Kazal_2. 1 hit.
PF03137. OATP. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 5 hits.
TIGRFAMsiTIGR00805. oat. 1 hit.
PROSITEiPS51465. KAZAL_2. 1 hit.
PS50850. MFS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSO1B3_HUMAN
AccessioniPrimary (citable) accession number: Q9NPD5
Secondary accession number(s): E7EMT8, Q5JAR4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 10, 2003
Last sequence update: October 1, 2000
Last modified: November 30, 2016
This is version 144 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.