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Protein

Myoneurin

Gene

MYNN

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri302 – 324C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri330 – 352C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri358 – 381C2H2-type 3PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri387 – 409C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri415 – 437C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri443 – 465C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri471 – 493C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri499 – 522C2H2-type 8PROSITE-ProRule annotationAdd BLAST24

GO - Molecular functioni

  • DNA binding Source: UniProtKB-KW
  • transcription factor activity, sequence-specific DNA binding Source: ProtInc
  • zinc ion binding Source: ProtInc

GO - Biological processi

  • transcription, DNA-templated Source: ProtInc
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

BioCyciZFISH:ENSG00000085274-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Myoneurin
Alternative name(s):
Zinc finger and BTB domain-containing protein 31
Gene namesi
Name:MYNN
Synonyms:OSZF, ZBTB31
ORF Names:SBBIZ1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:14955. MYNN.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi55892.
OpenTargetsiENSG00000085274.
PharmGKBiPA31393.

Polymorphism and mutation databases

BioMutaiMYNN.
DMDMi74761639.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002482171 – 610MyoneurinAdd BLAST610

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei289PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9NPC7.
MaxQBiQ9NPC7.
PaxDbiQ9NPC7.
PeptideAtlasiQ9NPC7.
PRIDEiQ9NPC7.

PTM databases

iPTMnetiQ9NPC7.
PhosphoSitePlusiQ9NPC7.

Expressioni

Tissue specificityi

Mainly expressed in the neuromuscular system. Located in and around synaptic myonuclei in adult muscle. Expression is dysregulated after nerve injury. Also found in the testis, ovary and placenta.2 Publications

Gene expression databases

BgeeiENSG00000085274.
ExpressionAtlasiQ9NPC7. baseline and differential.
GenevisibleiQ9NPC7. HS.

Organism-specific databases

HPAiHPA045149.

Interactioni

Protein-protein interaction databases

BioGridi120982. 6 interactors.
IntActiQ9NPC7. 2 interactors.
STRINGi9606.ENSP00000326240.

Structurei

Secondary structure

1610
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi4 – 20Combined sources17
Beta strandi26 – 30Combined sources5
Beta strandi33 – 37Combined sources5
Helixi39 – 45Combined sources7
Helixi47 – 53Combined sources7
Turni65 – 67Combined sources3
Helixi70 – 82Combined sources13
Turni89 – 91Combined sources3
Helixi92 – 101Combined sources10
Helixi105 – 115Combined sources11

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2VPKX-ray2.00A4-117[»]
ProteinModelPortaliQ9NPC7.
SMRiQ9NPC7.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9NPC7.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini24 – 89BTBPROSITE-ProRule annotationAdd BLAST66

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi174 – 190Nuclear localization signalSequence analysisAdd BLAST17
Motifi257 – 262Nuclear localization signalSequence analysis6

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi180 – 184Poly-Lys5

Sequence similaritiesi

Contains 1 BTB (POZ) domain.PROSITE-ProRule annotation
Contains 8 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri302 – 324C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri330 – 352C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri358 – 381C2H2-type 3PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri387 – 409C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri415 – 437C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri443 – 465C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri471 – 493C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri499 – 522C2H2-type 8PROSITE-ProRule annotationAdd BLAST24

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00860000133719.
HOVERGENiHBG055746.
InParanoidiQ9NPC7.
OMAiHCALKEH.
OrthoDBiEOG091G02KC.
PhylomeDBiQ9NPC7.
TreeFamiTF330787.

Family and domain databases

Gene3Di3.30.160.60. 8 hits.
InterProiIPR000210. BTB/POZ_dom.
IPR011333. SKP1/BTB/POZ.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00651. BTB. 1 hit.
PF00096. zf-C2H2. 2 hits.
PF13912. zf-C2H2_6. 2 hits.
[Graphical view]
SMARTiSM00225. BTB. 1 hit.
SM00355. ZnF_C2H2. 8 hits.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 8 hits.
PS50157. ZINC_FINGER_C2H2_2. 8 hits.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9NPC7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MQYSHHCEHL LERLNKQREA GFLCDCTIVI GEFQFKAHRN VLASFSEYFG
60 70 80 90 100
AIYRSTSENN VFLDQSQVKA DGFQKLLEFI YTGTLNLDSW NVKEIHQAAD
110 120 130 140 150
YLKVEEVVTK CKIKMEDFAF IANPSSTEIS SITGNIELNQ QTCLLTLRDY
160 170 180 190 200
NNREKSEVST DLIQANPKQG ALAKKSSQTK KKKKAFNSPK TGQNKTVQYP
210 220 230 240 250
SDILENASVE LFLDANKLPT PVVEQVAQIN DNSELELTSV VENTFPAQDI
260 270 280 290 300
VHTVTVKRKR GKSQPNCALK EHSMSNIASV KSPYEAENSG EELDQRYSKA
310 320 330 340 350
KPMCNTCGKV FSEASSLRRH MRIHKGVKPY VCHLCGKAFT QCNQLKTHVR
360 370 380 390 400
THTGEKPYKC ELCDKGFAQK CQLVFHSRMH HGEEKPYKCD VCNLQFATSS
410 420 430 440 450
NLKIHARKHS GEKPYVCDRC GQRFAQASTL TYHVRRHTGE KPYVCDTCGK
460 470 480 490 500
AFAVSSSLIT HSRKHTGEKP YICGICGKSF ISSGELNKHF RSHTGERPFI
510 520 530 540 550
CELCGNSYTD IKNLKKHKTK VHSGADKTLD SSAEDHTLSE QDSIQKSPLS
560 570 580 590 600
ETMDVKPSDM TLPLALPLGT EDHHMLLPVT DTQSPTSDTL LRSTVNGYSE
610
PQLIFLQQLY
Length:610
Mass (Da):68,682
Last modified:October 1, 2000 - v1
Checksum:i842B62DDC2C81480
GO
Isoform 2 (identifier: Q9NPC7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     496-524: Missing.

Show »
Length:581
Mass (Da):65,353
Checksum:iFDACC972CDB5B91E
GO
Isoform 3 (identifier: Q9NPC7-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     495-500: GERPFI → VVWSMN
     501-610: Missing.

Show »
Length:500
Mass (Da):56,545
Checksum:iCE38A314B03008E5
GO
Isoform 4 (identifier: Q9NPC7-4) [UniParc]FASTAAdd to basket
Also known as: m4b

The sequence of this isoform differs from the canonical sequence as follows:
     89-91: SWN → RDI
     92-610: Missing.

Show »
Length:91
Mass (Da):10,611
Checksum:iA3032286424DA0FC
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti198Q → R in BAC55898 (Ref. 2) Curated1
Sequence conflicti198Q → R in BAC55899 (Ref. 2) Curated1
Sequence conflicti292E → D in CAB61393 (PubMed:17974005).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_02021389 – 91SWN → RDI in isoform 4. 2 Publications3
Alternative sequenceiVSP_02021492 – 610Missing in isoform 4. 2 PublicationsAdd BLAST519
Alternative sequenceiVSP_020215495 – 500GERPFI → VVWSMN in isoform 3. 1 Publication6
Alternative sequenceiVSP_020216496 – 524Missing in isoform 2. 1 PublicationAdd BLAST29
Alternative sequenceiVSP_020217501 – 610Missing in isoform 3. 1 PublicationAdd BLAST110

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF148848 mRNA. Translation: AAF73138.1.
AY286322, AY286321 Genomic DNA. Translation: AAP44763.1.
AY286328
, AY286323, AY286325, AY286324, AY286326, AY286327 Genomic DNA. Translation: AAP44764.1.
AY514901 mRNA. Translation: AAR99055.1.
AY515294 Genomic DNA. Translation: AAR99843.1.
AY515691 mRNA. Translation: AAS38566.1.
AY515692 mRNA. Translation: AAS38567.1.
AY541760 mRNA. Translation: AAS87376.1.
AY541761 mRNA. Translation: AAS87377.1.
AB079777 mRNA. Translation: BAC55898.1.
AB079778 mRNA. Translation: BAC55899.1.
AB079779 Genomic DNA. Translation: BAC55900.1.
AF076249 mRNA. Translation: AAF80160.1.
AF155508 mRNA. Translation: AAF74822.1.
AK021646 mRNA. Translation: BAB13862.1.
AK092022 mRNA. Translation: BAG52468.1.
AK312527 mRNA. Translation: BAG35426.1.
AL133070 mRNA. Translation: CAB61393.1.
BX648128 mRNA. Translation: CAI46035.1.
CH471052 Genomic DNA. Translation: EAW78544.1.
CH471052 Genomic DNA. Translation: EAW78546.1.
BC033620 mRNA. Translation: AAH33620.1.
CCDSiCCDS3207.1. [Q9NPC7-1]
CCDS54671.1. [Q9NPC7-2]
PIRiJC7315.
T42670.
RefSeqiNP_001172047.1. NM_001185118.1. [Q9NPC7-1]
NP_001172048.1. NM_001185119.1. [Q9NPC7-2]
NP_061127.1. NM_018657.4. [Q9NPC7-1]
XP_011511289.1. XM_011512987.1. [Q9NPC7-1]
XP_016862353.1. XM_017006864.1. [Q9NPC7-1]
UniGeneiHs.507025.
Hs.630744.

Genome annotation databases

EnsembliENST00000349841; ENSP00000326240; ENSG00000085274. [Q9NPC7-1]
ENST00000356716; ENSP00000349150; ENSG00000085274. [Q9NPC7-1]
ENST00000544106; ENSP00000440637; ENSG00000085274. [Q9NPC7-2]
ENST00000602751; ENSP00000473654; ENSG00000085274. [Q9NPC7-4]
GeneIDi55892.
KEGGihsa:55892.
UCSCiuc003fft.4. human. [Q9NPC7-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF148848 mRNA. Translation: AAF73138.1.
AY286322, AY286321 Genomic DNA. Translation: AAP44763.1.
AY286328
, AY286323, AY286325, AY286324, AY286326, AY286327 Genomic DNA. Translation: AAP44764.1.
AY514901 mRNA. Translation: AAR99055.1.
AY515294 Genomic DNA. Translation: AAR99843.1.
AY515691 mRNA. Translation: AAS38566.1.
AY515692 mRNA. Translation: AAS38567.1.
AY541760 mRNA. Translation: AAS87376.1.
AY541761 mRNA. Translation: AAS87377.1.
AB079777 mRNA. Translation: BAC55898.1.
AB079778 mRNA. Translation: BAC55899.1.
AB079779 Genomic DNA. Translation: BAC55900.1.
AF076249 mRNA. Translation: AAF80160.1.
AF155508 mRNA. Translation: AAF74822.1.
AK021646 mRNA. Translation: BAB13862.1.
AK092022 mRNA. Translation: BAG52468.1.
AK312527 mRNA. Translation: BAG35426.1.
AL133070 mRNA. Translation: CAB61393.1.
BX648128 mRNA. Translation: CAI46035.1.
CH471052 Genomic DNA. Translation: EAW78544.1.
CH471052 Genomic DNA. Translation: EAW78546.1.
BC033620 mRNA. Translation: AAH33620.1.
CCDSiCCDS3207.1. [Q9NPC7-1]
CCDS54671.1. [Q9NPC7-2]
PIRiJC7315.
T42670.
RefSeqiNP_001172047.1. NM_001185118.1. [Q9NPC7-1]
NP_001172048.1. NM_001185119.1. [Q9NPC7-2]
NP_061127.1. NM_018657.4. [Q9NPC7-1]
XP_011511289.1. XM_011512987.1. [Q9NPC7-1]
XP_016862353.1. XM_017006864.1. [Q9NPC7-1]
UniGeneiHs.507025.
Hs.630744.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2VPKX-ray2.00A4-117[»]
ProteinModelPortaliQ9NPC7.
SMRiQ9NPC7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120982. 6 interactors.
IntActiQ9NPC7. 2 interactors.
STRINGi9606.ENSP00000326240.

PTM databases

iPTMnetiQ9NPC7.
PhosphoSitePlusiQ9NPC7.

Polymorphism and mutation databases

BioMutaiMYNN.
DMDMi74761639.

Proteomic databases

EPDiQ9NPC7.
MaxQBiQ9NPC7.
PaxDbiQ9NPC7.
PeptideAtlasiQ9NPC7.
PRIDEiQ9NPC7.

Protocols and materials databases

DNASUi55892.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000349841; ENSP00000326240; ENSG00000085274. [Q9NPC7-1]
ENST00000356716; ENSP00000349150; ENSG00000085274. [Q9NPC7-1]
ENST00000544106; ENSP00000440637; ENSG00000085274. [Q9NPC7-2]
ENST00000602751; ENSP00000473654; ENSG00000085274. [Q9NPC7-4]
GeneIDi55892.
KEGGihsa:55892.
UCSCiuc003fft.4. human. [Q9NPC7-1]

Organism-specific databases

CTDi55892.
DisGeNETi55892.
GeneCardsiMYNN.
HGNCiHGNC:14955. MYNN.
HPAiHPA045149.
MIMi606042. gene.
neXtProtiNX_Q9NPC7.
OpenTargetsiENSG00000085274.
PharmGKBiPA31393.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00860000133719.
HOVERGENiHBG055746.
InParanoidiQ9NPC7.
OMAiHCALKEH.
OrthoDBiEOG091G02KC.
PhylomeDBiQ9NPC7.
TreeFamiTF330787.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000085274-MONOMER.

Miscellaneous databases

ChiTaRSiMYNN. human.
EvolutionaryTraceiQ9NPC7.
GenomeRNAii55892.
PROiQ9NPC7.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000085274.
ExpressionAtlasiQ9NPC7. baseline and differential.
GenevisibleiQ9NPC7. HS.

Family and domain databases

Gene3Di3.30.160.60. 8 hits.
InterProiIPR000210. BTB/POZ_dom.
IPR011333. SKP1/BTB/POZ.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00651. BTB. 1 hit.
PF00096. zf-C2H2. 2 hits.
PF13912. zf-C2H2_6. 2 hits.
[Graphical view]
SMARTiSM00225. BTB. 1 hit.
SM00355. ZnF_C2H2. 8 hits.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 8 hits.
PS50157. ZINC_FINGER_C2H2_2. 8 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMYNN_HUMAN
AccessioniPrimary (citable) accession number: Q9NPC7
Secondary accession number(s): B2R6C9
, Q6QHA6, Q6QHA7, Q6R3G1, Q6R3G2, Q6R4A0, Q7Z716, Q7Z717, Q86Z11, Q86Z12, Q9NS01, Q9UIW8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 5, 2006
Last sequence update: October 1, 2000
Last modified: November 30, 2016
This is version 141 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.