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Q9NPC4

- A4GAT_HUMAN

UniProt

Q9NPC4 - A4GAT_HUMAN

Protein

Lactosylceramide 4-alpha-galactosyltransferase

Gene

A4GALT

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 123 (01 Oct 2014)
      Sequence version 1 (01 Oct 2000)
      Previous versions | rss
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    Functioni

    Necessary for the biosynthesis of the Pk antigen of blood histogroup P. Catalyzes the transfer of galactose to lactosylceramide and galactosylceramide. Necessary for the synthesis of the receptor for bacterial verotoxins.

    Catalytic activityi

    UDP-alpha-D-galactose + beta-D-galactosyl-(1->4)-D-glucosyl-(1<->1)-ceramide = UDP + alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-D-glucosyl-(1<->1)-ceramide.

    Pathwayi

    GO - Molecular functioni

    1. galactosyltransferase activity Source: UniProtKB
    2. lactosylceramide 4-alpha-galactosyltransferase activity Source: UniProtKB-EC

    GO - Biological processi

    1. glycosphingolipid biosynthetic process Source: UniProtKB
    2. plasma membrane organization Source: MGI
    3. protein glycosylation Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Keywords - Biological processi

    Lipid biosynthesis, Lipid metabolism

    Enzyme and pathway databases

    BRENDAi2.4.1.228. 2681.
    UniPathwayiUPA00378.

    Protein family/group databases

    CAZyiGT32. Glycosyltransferase Family 32.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Lactosylceramide 4-alpha-galactosyltransferase (EC:2.4.1.228)
    Alternative name(s):
    Alpha-1,4-N-acetylglucosaminyltransferase
    Alpha-1,4-galactosyltransferase
    Alpha4Gal-T1
    CD77 synthase
    Globotriaosylceramide synthase
    Short name:
    Gb3 synthase
    P1/Pk synthase
    UDP-galactose:beta-D-galactosyl-beta1-R 4-alpha-D-galactosyltransferase
    Gene namesi
    Name:A4GALT
    Synonyms:A14GALT, A4GALT1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 22

    Organism-specific databases

    HGNCiHGNC:18149. A4GALT.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular vesicular exosome Source: UniProt
    2. Golgi stack Source: InterPro
    3. integral component of Golgi membrane Source: UniProtKB
    4. membrane Source: MGI

    Keywords - Cellular componenti

    Golgi apparatus, Membrane

    Pathology & Biotechi

    Organism-specific databases

    MIMi111400. phenotype.
    PharmGKBiPA24359.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 353353Lactosylceramide 4-alpha-galactosyltransferasePRO_0000080578Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi121 – 1211N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi203 – 2031N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiQ9NPC4.
    PRIDEiQ9NPC4.

    PTM databases

    PhosphoSiteiQ9NPC4.

    Expressioni

    Tissue specificityi

    Ubiquitous. Highly expressed in kidney, heart, spleen, liver, testis and placenta.

    Gene expression databases

    ArrayExpressiQ9NPC4.
    BgeeiQ9NPC4.
    CleanExiHS_A4GALT.
    GenevestigatoriQ9NPC4.

    Organism-specific databases

    HPAiHPA001141.

    Interactioni

    Protein-protein interaction databases

    BioGridi119825. 1 interaction.
    IntActiQ9NPC4. 2 interactions.
    MINTiMINT-5210812.
    STRINGi9606.ENSP00000249005.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9NPC4.
    SMRiQ9NPC4. Positions 150-197.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2222CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini44 – 353310LumenalSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei23 – 4321Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi192 – 1943DXD motifBy similarity

    Domaini

    The conserved DXD motif is involved in enzyme activity.By similarity

    Sequence similaritiesi

    Belongs to the glycosyltransferase 32 family.Curated

    Keywords - Domaini

    Signal-anchor, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG251623.
    HOVERGENiHBG050427.
    InParanoidiQ9NPC4.
    KOiK01988.
    OMAiISFKFTF.
    OrthoDBiEOG75MVW8.
    PhylomeDBiQ9NPC4.
    TreeFamiTF324053.

    Family and domain databases

    InterProiIPR007652. A1-4-GlycosylTfrase_dom.
    IPR007577. GlycoTrfase_DXD_sugar-bd_CS.
    IPR029044. Nucleotide-diphossugar_trans.
    [Graphical view]
    PfamiPF04572. Gb3_synth. 1 hit.
    PF04488. Gly_transf_sug. 1 hit.
    [Graphical view]
    SUPFAMiSSF53448. SSF53448. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q9NPC4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSKPPDLLLR LLRGAPRQRV CTLFIIGFKF TFFVSIMIYW HVVGEPKEKG    50
    QLYNLPAEIP CPTLTPPTPP SHGPTPGNIF FLETSDRTNP NFLFMCSVES 100
    AARTHPESHV LVLMKGLPGG NASLPRHLGI SLLSCFPNVQ MLPLDLRELF 150
    RDTPLADWYA AVQGRWEPYL LPVLSDASRI ALMWKFGGIY LDTDFIVLKN 200
    LRNLTNVLGT QSRYVLNGAF LAFERRHEFM ALCMRDFVDH YNGWIWGHQG 250
    PQLLTRVFKK WCSIRSLAES RACRGVTTLP PEAFYPIPWQ DWKKYFEDIN 300
    PEELPRLLSA TYAVHVWNKK SQGTRFEATS RALLAQLHAR YCPTTHEAMK 350
    MYL 353
    Length:353
    Mass (Da):40,499
    Last modified:October 1, 2000 - v1
    Checksum:i8755865BDA5DA205
    GO

    Polymorphismi

    Genetic variation in A4GALT is responsible for the P system blood group phenotypes [MIMi:111400]. Different combinations or absence of the P blood group system antigens define 5 different phenotypes: P1, P2, P1(k), P2(k), and p. Genetic variation in A4GALT determines the p phenotype, which is rare and does not express any antigens. It is also known as null phenotype; p individuals have antibodies against P, P1 and Pk antigens in their sera. These antibodies are clinically important because they can cause severe transfusion reactions and miscarriage.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti37 – 371M → V.3 Publications
    Corresponds to variant rs11541159 [ dbSNP | Ensembl ].
    VAR_014296
    Natural varianti80 – 801Missing in p individuals. 1 Publication
    VAR_017507
    Natural varianti163 – 1631Q → R.1 Publication
    Corresponds to variant rs28915383 [ dbSNP | Ensembl ].
    VAR_022320
    Natural varianti183 – 1831M → K in p individuals; complete loss of activity. 2 Publications
    VAR_014297
    Natural varianti187 – 1871G → D in p individuals; partial loss of activity. 1 Publication
    Corresponds to variant rs28940572 [ dbSNP | Ensembl ].
    VAR_017508
    Natural varianti251 – 2511P → L in p individuals; complete loss of activity. 1 Publication
    Corresponds to variant rs28940571 [ dbSNP | Ensembl ].
    VAR_017509

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB037883 mRNA. Translation: BAA95915.1.
    AJ245581 mRNA. Translation: CAB93532.1.
    AB041418 Genomic DNA. Translation: BAA94503.1.
    AY941797 Genomic DNA. Translation: AAX20109.1.
    AK312927 mRNA. Translation: BAG35771.1.
    Z82176 Genomic DNA. Translation: CAI18757.1.
    CH471138 Genomic DNA. Translation: EAW73274.1.
    BC017068 mRNA. Translation: AAH17068.1.
    CCDSiCCDS14041.1.
    RefSeqiNP_059132.1. NM_017436.4.
    XP_005261700.1. XM_005261643.1.
    XP_005261701.1. XM_005261644.1.
    XP_005261703.1. XM_005261646.2.
    XP_005261704.1. XM_005261647.1.
    XP_005261705.1. XM_005261648.1.
    XP_006724328.1. XM_006724265.1.
    XP_006724329.1. XM_006724266.1.
    XP_006724330.1. XM_006724267.1.
    UniGeneiHs.105956.

    Genome annotation databases

    EnsembliENST00000249005; ENSP00000249005; ENSG00000128274.
    ENST00000381278; ENSP00000370678; ENSG00000128274.
    ENST00000401850; ENSP00000384794; ENSG00000128274.
    GeneIDi53947.
    KEGGihsa:53947.
    UCSCiuc003bdb.3. human.

    Polymorphism databases

    DMDMi25452796.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    GGDB

    GlycoGene database

    SeattleSNPs
    Functional Glycomics Gateway - GTase

    Lactosylceramide 4-alpha-galactosyltransferase

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB037883 mRNA. Translation: BAA95915.1 .
    AJ245581 mRNA. Translation: CAB93532.1 .
    AB041418 Genomic DNA. Translation: BAA94503.1 .
    AY941797 Genomic DNA. Translation: AAX20109.1 .
    AK312927 mRNA. Translation: BAG35771.1 .
    Z82176 Genomic DNA. Translation: CAI18757.1 .
    CH471138 Genomic DNA. Translation: EAW73274.1 .
    BC017068 mRNA. Translation: AAH17068.1 .
    CCDSi CCDS14041.1.
    RefSeqi NP_059132.1. NM_017436.4.
    XP_005261700.1. XM_005261643.1.
    XP_005261701.1. XM_005261644.1.
    XP_005261703.1. XM_005261646.2.
    XP_005261704.1. XM_005261647.1.
    XP_005261705.1. XM_005261648.1.
    XP_006724328.1. XM_006724265.1.
    XP_006724329.1. XM_006724266.1.
    XP_006724330.1. XM_006724267.1.
    UniGenei Hs.105956.

    3D structure databases

    ProteinModelPortali Q9NPC4.
    SMRi Q9NPC4. Positions 150-197.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 119825. 1 interaction.
    IntActi Q9NPC4. 2 interactions.
    MINTi MINT-5210812.
    STRINGi 9606.ENSP00000249005.

    Protein family/group databases

    CAZyi GT32. Glycosyltransferase Family 32.

    PTM databases

    PhosphoSitei Q9NPC4.

    Polymorphism databases

    DMDMi 25452796.

    Proteomic databases

    PaxDbi Q9NPC4.
    PRIDEi Q9NPC4.

    Protocols and materials databases

    DNASUi 53947.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000249005 ; ENSP00000249005 ; ENSG00000128274 .
    ENST00000381278 ; ENSP00000370678 ; ENSG00000128274 .
    ENST00000401850 ; ENSP00000384794 ; ENSG00000128274 .
    GeneIDi 53947.
    KEGGi hsa:53947.
    UCSCi uc003bdb.3. human.

    Organism-specific databases

    CTDi 53947.
    GeneCardsi GC22M043088.
    HGNCi HGNC:18149. A4GALT.
    HPAi HPA001141.
    MIMi 111400. phenotype.
    607922. gene.
    neXtProti NX_Q9NPC4.
    PharmGKBi PA24359.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG251623.
    HOVERGENi HBG050427.
    InParanoidi Q9NPC4.
    KOi K01988.
    OMAi ISFKFTF.
    OrthoDBi EOG75MVW8.
    PhylomeDBi Q9NPC4.
    TreeFami TF324053.

    Enzyme and pathway databases

    UniPathwayi UPA00378 .
    BRENDAi 2.4.1.228. 2681.

    Miscellaneous databases

    GeneWikii A4GALT.
    GenomeRNAii 53947.
    NextBioi 56264.
    PROi Q9NPC4.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9NPC4.
    Bgeei Q9NPC4.
    CleanExi HS_A4GALT.
    Genevestigatori Q9NPC4.

    Family and domain databases

    InterProi IPR007652. A1-4-GlycosylTfrase_dom.
    IPR007577. GlycoTrfase_DXD_sugar-bd_CS.
    IPR029044. Nucleotide-diphossugar_trans.
    [Graphical view ]
    Pfami PF04572. Gb3_synth. 1 hit.
    PF04488. Gly_transf_sug. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53448. SSF53448. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning of globotriaosylceramide/CD77 synthase, a glycosyltransferase that initiates the synthesis of globo series glycosphingolipids."
      Kojima Y., Fukumoto S., Furukawa K., Okajima T., Wiels J., Yokoyama K., Suzuki Y., Urano T., Ohta M., Furukawa K.
      J. Biol. Chem. 275:15152-15156(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Melanoma.
    2. "Cloning and expression of the histo-blood group Pk UDP-galactose:Galbeta1-4Glcbeta1-Cer alpha1,4-galactosyltransferase. Molecular genetic basis of the p phenotype."
      Steffensen R., Carlier K., Wiels J., Levery S.B., Stroud M., Cedergren B., Nilsson Sojka B., Bennett E.P., Jersild C., Clausen H.
      J. Biol. Chem. 275:16723-16729(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANTS VAL-37 AND LYS-183.
    3. "Human-specific amino acid changes found in 103 protein-coding genes."
      Kitano T., Liu Y.-H., Ueda S., Saitou N.
      Mol. Biol. Evol. 21:936-944(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    4. SeattleSNPs variation discovery resource
      Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS VAL-37 AND ARG-163.
    5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Tongue.
    6. "The DNA sequence of human chromosome 22."
      Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M., Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C., Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M.
      , Buck D., Burgess J., Burrill W.D., Burton J., Carder C., Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G., Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V., Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M., Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A., Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C., Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E., Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F., Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M., Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A., Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D., Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y., Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S., Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E., Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L., Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L., Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N., Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A., Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L., Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P., Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P., Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q., Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J., Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J., Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D., Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T., Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P., Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K., Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R., Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L., McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J., Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E., Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P., Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y., Wright H.
      Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Uterus.
    9. "Molecular basis for the p phenotype. Identification of distinct and multiple mutations in the alpha 1,4-galactosyltransferase gene in Swedish and Japanese individuals."
      Furukawa K., Iwamura K., Uchikawa M., Sojka B.N., Wiels J., Okajima T., Urano T., Furukawa K.
      J. Biol. Chem. 275:37752-37756(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANTS VAL-37; LYS-183; ASP-187 AND LEU-251.
    10. "Three-base deletion and one-base insertion of the alpha(1,4)galactosyltransferase gene responsible for the P phenotype."
      Koda Y., Soejima M., Sato H., Maeda Y., Kimura H.
      Transfusion 42:48-51(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANT PHE-80 DEL.

    Entry informationi

    Entry nameiA4GAT_HUMAN
    AccessioniPrimary (citable) accession number: Q9NPC4
    Secondary accession number(s): B2R7C4, Q9P1X5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 25, 2002
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 123 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 22
      Human chromosome 22: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3