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Q9NPC3

- CIP1_HUMAN

UniProt

Q9NPC3 - CIP1_HUMAN

Protein

E3 ubiquitin-protein ligase CCNB1IP1

Gene

CCNB1IP1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 119 (01 Oct 2014)
      Sequence version 1 (01 Oct 2000)
      Previous versions | rss
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    Functioni

    Ubiquitin E3 ligase that acts as a limiting factor for crossing-over during meiosis: required during zygonema to limit the colocalization of RNF212 with MutS-gamma-associated recombination sites and thereby establish early differentiation of crossover and non-crossover sites. Later, it is directed by MutL-gamma to stably accumulate at designated crossover sites. Probably promotes the dissociation of RNF212 and MutS-gamma to allow the progression of recombination and the implementation of the final steps of crossing over By similarity. Modulates cyclin-B levels and participates in the regulation of cell cycle progression through the G2 phase. Overexpression causes delayed entry into mitosis.By similarity
    E3 ubiquitin-protein ligase. Modulates cyclin B levels and participates in the regulation of cell cycle progression through the G2 phase. Overexpression causes delayed entry into mitosis.

    Pathwayi

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri4 – 5148RING-type; atypicalAdd
    BLAST

    GO - Molecular functioni

    1. ligase activity Source: UniProtKB-KW
    2. protein binding Source: IntAct
    3. zinc ion binding Source: InterPro

    GO - Biological processi

    1. blastocyst formation Source: Ensembl
    2. chiasma assembly Source: UniProtKB
    3. protein ubiquitination Source: UniProtKB-UniPathway
    4. reciprocal meiotic recombination Source: UniProtKB
    5. spermatid development Source: Ensembl

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Meiosis, Ubl conjugation pathway

    Keywords - Ligandi

    Metal-binding, Zinc

    Enzyme and pathway databases

    UniPathwayiUPA00143.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    E3 ubiquitin-protein ligase CCNB1IP1 (EC:6.3.2.-)
    Alternative name(s):
    Cyclin-B1-interacting protein 1
    Human enhancer of invasion 10
    Gene namesi
    Name:CCNB1IP1
    Synonyms:C14orf18, HEI10
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 14

    Organism-specific databases

    HGNCiHGNC:19437. CCNB1IP1.

    Subcellular locationi

    Nucleus. Chromosome
    Note: Associates to the synaptonemal complex.

    GO - Cellular componenti

    1. chromosome Source: UniProtKB-SubCell
    2. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Chromosome, Nucleus

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi28 – 281C → A: Abrogates induction of filamentous growth in yeast; when associated with A-30 and A-33. 1 Publication
    Mutagenesisi30 – 301H → A: Abrogates induction of filamentous growth in yeast; when associated with A-28 and A-33. 1 Publication
    Mutagenesisi33 – 331C → A: Abrogates induction of filamentous growth in yeast; when associated with A-28 and A-30. 1 Publication

    Organism-specific databases

    PharmGKBiPA134863884.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 277277E3 ubiquitin-protein ligase CCNB1IP1PRO_0000055874Add
    BLAST

    Post-translational modificationi

    Ubiquitinated; autoubiquitinated.1 Publication
    Phosphorylated by CDK1 on serine or threonine residues (in vitro).1 Publication

    Keywords - PTMi

    Phosphoprotein, Ubl conjugation

    Proteomic databases

    PaxDbiQ9NPC3.
    PRIDEiQ9NPC3.

    PTM databases

    PhosphoSiteiQ9NPC3.

    Expressioni

    Tissue specificityi

    Highly expressed in heart. Detected at intermediate levels in liver and kidney, and at low levels in placenta, brain and lung.1 Publication

    Gene expression databases

    ArrayExpressiQ9NPC3.
    BgeeiQ9NPC3.
    CleanExiHS_CCNB1IP1.
    GenevestigatoriQ9NPC3.

    Interactioni

    Subunit structurei

    Interacts with CCNB1, UBE2L3 and NF2.2 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    P629722EBI-745269,EBI-412964From a different organism.
    CCNB1P146352EBI-745269,EBI-495332

    Protein-protein interaction databases

    BioGridi121779. 6 interactions.
    IntActiQ9NPC3. 4 interactions.
    MINTiMINT-1450464.
    STRINGi9606.ENSP00000337396.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9NPC3.
    SMRiQ9NPC3. Positions 6-58.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili127 – 18256Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Contains 1 RING-type zinc finger.Curated

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri4 – 5148RING-type; atypicalAdd
    BLAST

    Keywords - Domaini

    Coiled coil, Zinc-finger

    Phylogenomic databases

    eggNOGiNOG27432.
    HOGENOMiHOG000111677.
    HOVERGENiHBG050962.
    InParanoidiQ9NPC3.
    KOiK10639.
    OMAiIANHEGT.
    OrthoDBiEOG76MK99.
    PhylomeDBiQ9NPC3.
    TreeFamiTF328863.

    Family and domain databases

    InterProiIPR001841. Znf_RING.
    [Graphical view]
    PfamiPF14634. zf-RING_5. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9NPC3-1 [UniParc]FASTAAdd to Basket

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    MSLCEDMLLC NYRKCRIKLS GYAWVTACSH IFCDQHGSGE FSRSPAICPA    50
    CNSTLSGKLD IVRTELSPSE EYKAMVLAGL RPEIVLDISS RALAFWTYQV 100
    HQERLYQEYN FSKAEGHLKQ MEKIYTQQIQ SKDVELTSMK GEVTSMKKVL 150
    EEYKKKFSDI SEKLMERNRQ YQKLQGLYDS LRLRNITIAN HEGTLEPSMI 200
    AQSGVLGFPL GNNSKFPLDN TPVRNRGDGD GDFQFRPFFA GSPTAPEPSN 250
    SFFSFVSPSR ELEQQQVSSR AFKVKRI 277
    Length:277
    Mass (Da):31,544
    Last modified:October 1, 2000 - v1
    Checksum:i885723B01A35225A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF216381 mRNA. Translation: AAF36386.1.
    AL161994 mRNA. Translation: CAB82326.1.
    AK026233 mRNA. Translation: BAB15403.1.
    BX161423 mRNA. Translation: CAD61896.1.
    BX161424 mRNA. Translation: CAD61897.1.
    BX247978 mRNA. Translation: CAD62312.1.
    BC000369 mRNA. Translation: AAH00369.1.
    BC001218 mRNA. Translation: AAH01218.1.
    BC004435 mRNA. Translation: AAH04435.1.
    CCDSiCCDS9547.1.
    PIRiT47153.
    RefSeqiNP_067001.3. NM_021178.4.
    NP_878269.1. NM_182849.2.
    NP_878272.1. NM_182852.3.
    UniGeneiHs.107003.
    Hs.741214.

    Genome annotation databases

    EnsembliENST00000353689; ENSP00000337396; ENSG00000100814.
    ENST00000358932; ENSP00000351810; ENSG00000100814.
    ENST00000398160; ENSP00000381226; ENSG00000100814.
    ENST00000398163; ENSP00000381229; ENSG00000100814.
    ENST00000398169; ENSP00000381235; ENSG00000100814.
    ENST00000437553; ENSP00000409896; ENSG00000100814.
    GeneIDi57820.
    KEGGihsa:57820.
    UCSCiuc001vwv.4. human.

    Polymorphism databases

    DMDMi37078756.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF216381 mRNA. Translation: AAF36386.1 .
    AL161994 mRNA. Translation: CAB82326.1 .
    AK026233 mRNA. Translation: BAB15403.1 .
    BX161423 mRNA. Translation: CAD61896.1 .
    BX161424 mRNA. Translation: CAD61897.1 .
    BX247978 mRNA. Translation: CAD62312.1 .
    BC000369 mRNA. Translation: AAH00369.1 .
    BC001218 mRNA. Translation: AAH01218.1 .
    BC004435 mRNA. Translation: AAH04435.1 .
    CCDSi CCDS9547.1.
    PIRi T47153.
    RefSeqi NP_067001.3. NM_021178.4.
    NP_878269.1. NM_182849.2.
    NP_878272.1. NM_182852.3.
    UniGenei Hs.107003.
    Hs.741214.

    3D structure databases

    ProteinModelPortali Q9NPC3.
    SMRi Q9NPC3. Positions 6-58.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 121779. 6 interactions.
    IntActi Q9NPC3. 4 interactions.
    MINTi MINT-1450464.
    STRINGi 9606.ENSP00000337396.

    PTM databases

    PhosphoSitei Q9NPC3.

    Polymorphism databases

    DMDMi 37078756.

    Proteomic databases

    PaxDbi Q9NPC3.
    PRIDEi Q9NPC3.

    Protocols and materials databases

    DNASUi 57820.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000353689 ; ENSP00000337396 ; ENSG00000100814 .
    ENST00000358932 ; ENSP00000351810 ; ENSG00000100814 .
    ENST00000398160 ; ENSP00000381226 ; ENSG00000100814 .
    ENST00000398163 ; ENSP00000381229 ; ENSG00000100814 .
    ENST00000398169 ; ENSP00000381235 ; ENSG00000100814 .
    ENST00000437553 ; ENSP00000409896 ; ENSG00000100814 .
    GeneIDi 57820.
    KEGGi hsa:57820.
    UCSCi uc001vwv.4. human.

    Organism-specific databases

    CTDi 57820.
    GeneCardsi GC14M020779.
    HGNCi HGNC:19437. CCNB1IP1.
    MIMi 608249. gene.
    neXtProti NX_Q9NPC3.
    PharmGKBi PA134863884.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG27432.
    HOGENOMi HOG000111677.
    HOVERGENi HBG050962.
    InParanoidi Q9NPC3.
    KOi K10639.
    OMAi IANHEGT.
    OrthoDBi EOG76MK99.
    PhylomeDBi Q9NPC3.
    TreeFami TF328863.

    Enzyme and pathway databases

    UniPathwayi UPA00143 .

    Miscellaneous databases

    GeneWikii CCNB1IP1.
    GenomeRNAii 57820.
    NextBioi 64776.
    PROi Q9NPC3.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9NPC3.
    Bgeei Q9NPC3.
    CleanExi HS_CCNB1IP1.
    Genevestigatori Q9NPC3.

    Family and domain databases

    InterProi IPR001841. Znf_RING.
    [Graphical view ]
    Pfami PF14634. zf-RING_5. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A novel RING finger protein, human enhancer of invasion 10, alters mitotic progression through regulation of cyclin B levels."
      Toby G.G., Gherraby W., Coleman T.R., Golemis E.A.
      Mol. Cell. Biol. 23:2109-2122(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], MUTAGENESIS OF CYS-28; HIS-30 AND CYS-33, FUNCTION, INTERACTION WITH UBE2L3 AND CCNB1, UBIQUITINATION, PHOSPHORYLATION, TISSUE SPECIFICITY.
      Tissue: Cervix carcinoma.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Small intestine.
    4. "Full-length cDNA libraries and normalization."
      Li W.B., Gruber C., Jessee J., Polayes D.
      Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Fetal brain and Placenta.
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Lung and Muscle.
    6. "A functional association between merlin and HEI10, a cell cycle regulator."
      Gronholm M., Muranen T., Toby G.G., Utermark T., Hanemann C.O., Golemis E.A., Carpen O.
      Oncogene 25:4389-4398(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH NF2.
    7. "HEI10 negatively regulates cell invasion by inhibiting cyclin B/Cdk1 and other promotility proteins."
      Singh M.K., Nicolas E., Gherraby W., Dadke D., Lessin S., Golemis E.A.
      Oncogene 26:4825-4832(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.

    Entry informationi

    Entry nameiCIP1_HUMAN
    AccessioniPrimary (citable) accession number: Q9NPC3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 26, 2003
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 119 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 14
      Human chromosome 14: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3