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Protein

E3 ubiquitin-protein ligase CCNB1IP1

Gene

CCNB1IP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Ubiquitin E3 ligase that acts as a limiting factor for crossing-over during meiosis: required during zygonema to limit the colocalization of RNF212 with MutS-gamma-associated recombination sites and thereby establish early differentiation of crossover and non-crossover sites. Later, it is directed by MutL-gamma to stably accumulate at designated crossover sites. Probably promotes the dissociation of RNF212 and MutS-gamma to allow the progression of recombination and the implementation of the final steps of crossing over (By similarity). Modulates cyclin-B levels and participates in the regulation of cell cycle progression through the G2 phase. Overexpression causes delayed entry into mitosis.By similarity2 Publications
E3 ubiquitin-protein ligase. Modulates cyclin B levels and participates in the regulation of cell cycle progression through the G2 phase. Overexpression causes delayed entry into mitosis.

Catalytic activityi

S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N6-ubiquitinyl-[acceptor protein]-L-lysine.1 Publication

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri4 – 51RING-type; atypicalAdd BLAST48

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processMeiosis, Ubl conjugation pathway
LigandMetal-binding, Zinc

Enzyme and pathway databases

UniPathwayiUPA00143

Names & Taxonomyi

Protein namesi
Recommended name:
E3 ubiquitin-protein ligase CCNB1IP1 (EC:2.3.2.271 Publication)
Alternative name(s):
Cyclin-B1-interacting protein 1
Human enhancer of invasion 10
RING-type E3 ubiquitin transferase CCNB1IP1Curated
Gene namesi
Name:CCNB1IP1
Synonyms:C14orf18, HEI10
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

EuPathDBiHostDB:ENSG00000100814.17
HGNCiHGNC:19437 CCNB1IP1
MIMi608249 gene
neXtProtiNX_Q9NPC3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi28C → A: Abrogates induction of filamentous growth in yeast; when associated with A-30 and A-33. 1 Publication1
Mutagenesisi30H → A: Abrogates induction of filamentous growth in yeast; when associated with A-28 and A-33. 1 Publication1
Mutagenesisi33C → A: Abrogates induction of filamentous growth in yeast; when associated with A-28 and A-30. 1 Publication1

Organism-specific databases

OpenTargetsiENSG00000100814
PharmGKBiPA134863884

Polymorphism and mutation databases

BioMutaiCCNB1IP1
DMDMi37078756

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000558741 – 277E3 ubiquitin-protein ligase CCNB1IP1Add BLAST277

Post-translational modificationi

Ubiquitinated; autoubiquitinated.1 Publication
Phosphorylated by CDK1 on serine or threonine residues (in vitro).1 Publication

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiQ9NPC3
PeptideAtlasiQ9NPC3
PRIDEiQ9NPC3

PTM databases

iPTMnetiQ9NPC3
PhosphoSitePlusiQ9NPC3

Expressioni

Tissue specificityi

Highly expressed in heart. Detected at intermediate levels in liver and kidney, and at low levels in placenta, brain and lung.1 Publication

Gene expression databases

BgeeiENSG00000100814
CleanExiHS_CCNB1IP1
ExpressionAtlasiQ9NPC3 baseline and differential
GenevisibleiQ9NPC3 HS

Interactioni

Subunit structurei

Interacts with CCNB1, UBE2L3 and NF2.2 Publications

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi121779, 12 interactors
IntActiQ9NPC3, 12 interactors
STRINGi9606.ENSP00000337396

Structurei

3D structure databases

ProteinModelPortaliQ9NPC3
SMRiQ9NPC3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili127 – 182Sequence analysisAdd BLAST56

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri4 – 51RING-type; atypicalAdd BLAST48

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

eggNOGiENOG410IE9K Eukaryota
ENOG410XTEP LUCA
GeneTreeiENSGT00390000002849
HOGENOMiHOG000111677
HOVERGENiHBG050962
InParanoidiQ9NPC3
KOiK10639
OMAiIANHEGT
OrthoDBiEOG091G0RN7
PhylomeDBiQ9NPC3
TreeFamiTF328863

Family and domain databases

InterProiView protein in InterPro
IPR001841 Znf_RING
PfamiView protein in Pfam
PF14634 zf-RING_5, 1 hit

Sequencei

Sequence statusi: Complete.

Q9NPC3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLCEDMLLC NYRKCRIKLS GYAWVTACSH IFCDQHGSGE FSRSPAICPA
60 70 80 90 100
CNSTLSGKLD IVRTELSPSE EYKAMVLAGL RPEIVLDISS RALAFWTYQV
110 120 130 140 150
HQERLYQEYN FSKAEGHLKQ MEKIYTQQIQ SKDVELTSMK GEVTSMKKVL
160 170 180 190 200
EEYKKKFSDI SEKLMERNRQ YQKLQGLYDS LRLRNITIAN HEGTLEPSMI
210 220 230 240 250
AQSGVLGFPL GNNSKFPLDN TPVRNRGDGD GDFQFRPFFA GSPTAPEPSN
260 270
SFFSFVSPSR ELEQQQVSSR AFKVKRI
Length:277
Mass (Da):31,544
Last modified:October 1, 2000 - v1
Checksum:i885723B01A35225A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF216381 mRNA Translation: AAF36386.1
AL161994 mRNA Translation: CAB82326.1
AK026233 mRNA Translation: BAB15403.1
BX161423 mRNA Translation: CAD61896.1
BX161424 mRNA Translation: CAD61897.1
BX247978 mRNA Translation: CAD62312.1
BC000369 mRNA Translation: AAH00369.1
BC001218 mRNA Translation: AAH01218.1
BC004435 mRNA Translation: AAH04435.1
CCDSiCCDS9547.1
PIRiT47153
RefSeqiNP_067001.3, NM_021178.4
NP_878269.1, NM_182849.2
NP_878272.1, NM_182852.3
UniGeneiHs.107003
Hs.741214

Genome annotation databases

EnsembliENST00000353689; ENSP00000337396; ENSG00000100814
ENST00000358932; ENSP00000351810; ENSG00000100814
ENST00000398160; ENSP00000381226; ENSG00000100814
ENST00000398163; ENSP00000381229; ENSG00000100814
ENST00000398169; ENSP00000381235; ENSG00000100814
ENST00000437553; ENSP00000409896; ENSG00000100814
GeneIDi57820
KEGGihsa:57820
UCSCiuc001vwv.5 human

Similar proteinsi

Entry informationi

Entry nameiCIP1_HUMAN
AccessioniPrimary (citable) accession number: Q9NPC3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 26, 2003
Last sequence update: October 1, 2000
Last modified: March 28, 2018
This is version 150 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health