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Q9NPC2

- KCNK9_HUMAN

UniProt

Q9NPC2 - KCNK9_HUMAN

Protein

Potassium channel subfamily K member 9

Gene

KCNK9

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 119 (01 Oct 2014)
      Sequence version 1 (01 Oct 2000)
      Previous versions | rss
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    Functioni

    pH-dependent, voltage-insensitive, background potassium channel protein.2 Publications

    GO - Molecular functioni

    1. potassium channel activity Source: UniProtKB-KW
    2. voltage-gated ion channel activity Source: UniProtKB-KW

    GO - Biological processi

    1. cochlea development Source: Ensembl
    2. potassium ion transport Source: UniProtKB
    3. synaptic transmission Source: Reactome

    Keywords - Molecular functioni

    Ion channel, Potassium channel, Voltage-gated channel

    Keywords - Biological processi

    Ion transport, Potassium transport, Transport

    Keywords - Ligandi

    Potassium

    Enzyme and pathway databases

    ReactomeiREACT_75899. TWIK-releated acid-sensitive K+ channel (TASK).

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Potassium channel subfamily K member 9
    Alternative name(s):
    Acid-sensitive potassium channel protein TASK-3
    TWIK-related acid-sensitive K(+) channel 3
    Two pore potassium channel KT3.2
    Short name:
    Two pore K(+) channel KT3.2
    Gene namesi
    Name:KCNK9
    Synonyms:TASK3
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 8

    Organism-specific databases

    HGNCiHGNC:6283. KCNK9.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: Reactome
    3. synaptic vesicle Source: Ensembl

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Involvement in diseasei

    Birk-Barel mental retardation dysmorphism syndrome (BIBAS) [MIM:612292]: A syndrome characterized by mental retardation, hypotonia, hyperactivity, and facial dysmorphism.1 Publication
    Note: The disease is caused by mutations affecting the gene represented in this entry.
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti236 – 2361G → R in BIBAS; inactive. 1 Publication
    VAR_054373

    Keywords - Diseasei

    Disease mutation, Mental retardation

    Organism-specific databases

    MIMi612292. phenotype.
    Orphaneti166108. intellectual disability, Birk-Barel type.
    PharmGKBiPA30065.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 374374Potassium channel subfamily K member 9PRO_0000101754Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi53 – 531N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiQ9NPC2.
    PRIDEiQ9NPC2.

    PTM databases

    PhosphoSiteiQ9NPC2.

    Expressioni

    Tissue specificityi

    Mainly found in the cerebellum. Also found in adrenal gland, kidney and lung.2 Publications

    Gene expression databases

    BgeeiQ9NPC2.
    CleanExiHS_KCNK9.
    GenevestigatoriQ9NPC2.

    Interactioni

    Protein-protein interaction databases

    BioGridi119456. 2 interactions.
    STRINGi9606.ENSP00000302166.

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3P1NX-ray1.40P369-374[»]
    3P1OX-ray1.90P369-374[»]
    3P1PX-ray1.95P369-374[»]
    3P1QX-ray1.70P369-374[»]
    3P1RX-ray1.70P369-374[»]
    3P1SX-ray1.65P369-374[»]
    3SMKX-ray2.10P369-374[»]
    3SMLX-ray1.90P370-374[»]
    3SMMX-ray2.00P369-374[»]
    3SMNX-ray2.00P369-374[»]
    3SMOX-ray1.80P369-374[»]
    3SPRX-ray1.99P369-374[»]
    3UX0X-ray1.75P369-374[»]
    4FR3X-ray1.90P369-374[»]
    ProteinModelPortaliQ9NPC2.
    SMRiQ9NPC2. Positions 22-242.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ9NPC2.

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 88CytoplasmicSequence Analysis
    Topological domaini30 – 8859ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini102 – 1076ExtracellularSequence Analysis
    Topological domaini129 – 15830CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini180 – 19415ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini208 – 21811ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini240 – 374135CytoplasmicSequence AnalysisAdd
    BLAST

    Intramembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Intramembranei89 – 10113Pore-forming; Name=Pore-forming 1Sequence AnalysisAdd
    BLAST
    Intramembranei195 – 20713Pore-forming; Name=Pore-forming 2Sequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei9 – 2921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei108 – 12821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei159 – 17921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei219 – 23921HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG259548.
    HOGENOMiHOG000231463.
    HOVERGENiHBG052239.
    InParanoidiQ9NPC2.
    KOiK04919.
    OMAiMRRRKSV.
    OrthoDBiEOG7B05DC.
    PhylomeDBiQ9NPC2.
    TreeFamiTF313947.

    Family and domain databases

    InterProiIPR003280. 2pore_dom_K_chnl.
    IPR013099. 2pore_dom_K_chnl_dom.
    IPR003092. 2pore_dom_K_chnl_TASK.
    IPR005407. KCNK9.
    [Graphical view]
    PfamiPF07885. Ion_trans_2. 2 hits.
    [Graphical view]
    PIRSFiPIRSF038061. K_channel_subfamily_K_type. 1 hit.
    PRINTSiPR01333. 2POREKCHANEL.
    PR01585. TASK3CHANNEL.
    PR01095. TASKCHANNEL.

    Sequencei

    Sequence statusi: Complete.

    Q9NPC2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKRQNVRTLS LIVCTFTYLL VGAAVFDALE SDHEMREEEK LKAEEIRIKG    50
    KYNISSEDYR QLELVILQSE PHRAGVQWKF AGSFYFAITV ITTIGYGHAA 100
    PGTDAGKAFC MFYAVLGIPL TLVMFQSLGE RMNTFVRYLL KRIKKCCGMR 150
    NTDVSMENMV TVGFFSCMGT LCIGAAAFSQ CEEWSFFHAY YYCFITLTTI 200
    GFGDYVALQT KGALQKKPLY VAFSFMYILV GLTVIGAFLN LVVLRFLTMN 250
    SEDERRDAEE RASLAGNRNS MVIHIPEEPR PSRPRYKADV PDLQSVCSCT 300
    CYRSQDYGGR SVAPQNSFSA KLAPHYFHSI SYKIEEISPS TLKNSLFPSP 350
    ISSISPGLHS FTDHQRLMKR RKSV 374
    Length:374
    Mass (Da):42,264
    Last modified:October 1, 2000 - v1
    Checksum:i8A19EAEE5A4D7F38
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti236 – 2361G → R in BIBAS; inactive. 1 Publication
    VAR_054373

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF212829 mRNA. Translation: AAF63708.1.
    AF248241 mRNA. Translation: AAG31730.1.
    AF257080 mRNA. Translation: AAG33126.1.
    AY190605 mRNA. Translation: AAO38739.1.
    AF279809 mRNA. Translation: AAF85982.1.
    BC075079 mRNA. Translation: AAH75079.1.
    BC075080 mRNA. Translation: AAH75080.1.
    BC112063 mRNA. Translation: AAI12064.1.
    BC112065 mRNA. Translation: AAI12066.1.
    CCDSiCCDS6377.1.
    RefSeqiNP_001269463.1. NM_001282534.1.
    UniGeneiHs.493037.
    Hs.553147.
    Hs.664608.

    Genome annotation databases

    EnsembliENST00000303015; ENSP00000302166; ENSG00000169427.
    ENST00000520439; ENSP00000430676; ENSG00000169427.
    ENST00000522317; ENSP00000429847; ENSG00000169427.
    GeneIDi51305.
    KEGGihsa:51305.
    UCSCiuc003yvf.1. human.

    Polymorphism databases

    DMDMi13431426.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF212829 mRNA. Translation: AAF63708.1 .
    AF248241 mRNA. Translation: AAG31730.1 .
    AF257080 mRNA. Translation: AAG33126.1 .
    AY190605 mRNA. Translation: AAO38739.1 .
    AF279809 mRNA. Translation: AAF85982.1 .
    BC075079 mRNA. Translation: AAH75079.1 .
    BC075080 mRNA. Translation: AAH75080.1 .
    BC112063 mRNA. Translation: AAI12064.1 .
    BC112065 mRNA. Translation: AAI12066.1 .
    CCDSi CCDS6377.1.
    RefSeqi NP_001269463.1. NM_001282534.1.
    UniGenei Hs.493037.
    Hs.553147.
    Hs.664608.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3P1N X-ray 1.40 P 369-374 [» ]
    3P1O X-ray 1.90 P 369-374 [» ]
    3P1P X-ray 1.95 P 369-374 [» ]
    3P1Q X-ray 1.70 P 369-374 [» ]
    3P1R X-ray 1.70 P 369-374 [» ]
    3P1S X-ray 1.65 P 369-374 [» ]
    3SMK X-ray 2.10 P 369-374 [» ]
    3SML X-ray 1.90 P 370-374 [» ]
    3SMM X-ray 2.00 P 369-374 [» ]
    3SMN X-ray 2.00 P 369-374 [» ]
    3SMO X-ray 1.80 P 369-374 [» ]
    3SPR X-ray 1.99 P 369-374 [» ]
    3UX0 X-ray 1.75 P 369-374 [» ]
    4FR3 X-ray 1.90 P 369-374 [» ]
    ProteinModelPortali Q9NPC2.
    SMRi Q9NPC2. Positions 22-242.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 119456. 2 interactions.
    STRINGi 9606.ENSP00000302166.

    Chemistry

    ChEMBLi CHEMBL2321614.
    GuidetoPHARMACOLOGYi 520.

    PTM databases

    PhosphoSitei Q9NPC2.

    Polymorphism databases

    DMDMi 13431426.

    Proteomic databases

    PaxDbi Q9NPC2.
    PRIDEi Q9NPC2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000303015 ; ENSP00000302166 ; ENSG00000169427 .
    ENST00000520439 ; ENSP00000430676 ; ENSG00000169427 .
    ENST00000522317 ; ENSP00000429847 ; ENSG00000169427 .
    GeneIDi 51305.
    KEGGi hsa:51305.
    UCSCi uc003yvf.1. human.

    Organism-specific databases

    CTDi 51305.
    GeneCardsi GC08M140693.
    HGNCi HGNC:6283. KCNK9.
    MIMi 605874. gene.
    612292. phenotype.
    neXtProti NX_Q9NPC2.
    Orphaneti 166108. intellectual disability, Birk-Barel type.
    PharmGKBi PA30065.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG259548.
    HOGENOMi HOG000231463.
    HOVERGENi HBG052239.
    InParanoidi Q9NPC2.
    KOi K04919.
    OMAi MRRRKSV.
    OrthoDBi EOG7B05DC.
    PhylomeDBi Q9NPC2.
    TreeFami TF313947.

    Enzyme and pathway databases

    Reactomei REACT_75899. TWIK-releated acid-sensitive K+ channel (TASK).

    Miscellaneous databases

    EvolutionaryTracei Q9NPC2.
    GeneWikii KCNK9.
    GenomeRNAii 51305.
    NextBioi 54617.
    PROi Q9NPC2.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9NPC2.
    CleanExi HS_KCNK9.
    Genevestigatori Q9NPC2.

    Family and domain databases

    InterProi IPR003280. 2pore_dom_K_chnl.
    IPR013099. 2pore_dom_K_chnl_dom.
    IPR003092. 2pore_dom_K_chnl_TASK.
    IPR005407. KCNK9.
    [Graphical view ]
    Pfami PF07885. Ion_trans_2. 2 hits.
    [Graphical view ]
    PIRSFi PIRSF038061. K_channel_subfamily_K_type. 1 hit.
    PRINTSi PR01333. 2POREKCHANEL.
    PR01585. TASK3CHANNEL.
    PR01095. TASKCHANNEL.
    ProtoNeti Search...

    Publicationsi

    1. "TASK-3, a novel tandem pore domain acid-sensitive K+ channel. An extracellular histidine as pH sensor."
      Rajan S., Wischmeyer E., Liu G.X., Preisig-Mueller R., Daut J., Karschin A., Derst C.
      J. Biol. Chem. 275:16650-16657(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Cloning, localisation and functional expression of a novel human, cerebellum specific, two pore domain potassium channel."
      Chapman C.G., Meadows H.J., Godden R.J., Campbell D.A., Duckworth M., Kelsell R.E., Murdock P.R., Randall A.D., Rennie G.I., Gloger I.S.
      Brain Res. Mol. Brain Res. 82:74-83(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
      Tissue: Cerebellum.
    3. "KT3.2 and KT3.3, two novel human two-pore K(+) channels closely related to TASK-1."
      Vega-Saenz de Miera E., Lau D.H.P., Zhadina M., Pountney D., Coetzee W.A., Rudy B.
      J. Neurophysiol. 86:130-142(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
    4. Cited for: NUCLEOTIDE SEQUENCE [MRNA], OVEREXPRESSION IN BREAST CANCERS.
    5. "Human Task-3, a novel 2P domain potassium channel related to Task."
      Girard C., Lesage F., Tinel N., Lazdunski M.
      Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    7. "Maternally inherited Birk Barel mental retardation dysmorphism syndrome caused by a mutation in the genomically imprinted potassium channel KCNK9."
      Barel O., Shalev S.A., Ofir R., Cohen A., Zlotogora J., Shorer Z., Mazor G., Finer G., Khateeb S., Zilberberg N., Birk O.S.
      Am. J. Hum. Genet. 83:193-199(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANT BIBAS ARG-236, CHARACTERIZATION OF VARIANT BIBAS ARG-236.

    Entry informationi

    Entry nameiKCNK9_HUMAN
    AccessioniPrimary (citable) accession number: Q9NPC2
    Secondary accession number(s): Q2M290, Q540F2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 27, 2001
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 119 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    Inhibited by phorbol 12-myristate 13-acetate (PMA). TASK-3 current is strongly decreased in the presence of an extracellular pH inferior to 7.0.
    Overexpressed in a high proportion of breast cancers. May confer resistance to growth factor deprivation and hypoxia, thereby promoting tumor cell survival in poorly oxygenated areas of solid tumors.

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 8
      Human chromosome 8: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3