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Protein

Potassium channel subfamily K member 9

Gene

KCNK9

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

pH-dependent, voltage-insensitive, background potassium channel protein.3 Publications

Miscellaneous

Inhibited by phorbol 12-myristate 13-acetate (PMA). TASK-3 current is strongly decreased in the presence of an extracellular pH inferior to 7.0.
Overexpressed in a high proportion of breast cancers. May confer resistance to growth factor deprivation and hypoxia, thereby promoting tumor cell survival in poorly oxygenated areas of solid tumors.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIon channel, Potassium channel
Biological processIon transport, Potassium transport, Transport
LigandPotassium

Enzyme and pathway databases

ReactomeiR-HSA-1299316 TWIK-releated acid-sensitive K+ channel (TASK)
R-HSA-5576886 Phase 4 - resting membrane potential
SIGNORiQ9NPC2

Protein family/group databases

TCDBi1.A.1.9.11 the voltage-gated ion channel (vic) superfamily

Names & Taxonomyi

Protein namesi
Recommended name:
Potassium channel subfamily K member 9
Alternative name(s):
Acid-sensitive potassium channel protein TASK-3
TWIK-related acid-sensitive K(+) channel 3
Two pore potassium channel KT3.2
Short name:
Two pore K(+) channel KT3.2
Gene namesi
Name:KCNK9
Synonyms:TASK3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

EuPathDBiHostDB:ENSG00000169427.6
HGNCiHGNC:6283 KCNK9
MIMi605874 gene
neXtProtiNX_Q9NPC2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 8CytoplasmicSequence analysis8
Transmembranei9 – 29HelicalSequence analysisAdd BLAST21
Topological domaini30 – 88ExtracellularSequence analysisAdd BLAST59
Intramembranei89 – 101Pore-forming; Name=Pore-forming 1Sequence analysisAdd BLAST13
Topological domaini102 – 107ExtracellularSequence analysis6
Transmembranei108 – 128HelicalSequence analysisAdd BLAST21
Topological domaini129 – 158CytoplasmicSequence analysisAdd BLAST30
Transmembranei159 – 179HelicalSequence analysisAdd BLAST21
Topological domaini180 – 194ExtracellularSequence analysisAdd BLAST15
Intramembranei195 – 207Pore-forming; Name=Pore-forming 2Sequence analysisAdd BLAST13
Topological domaini208 – 218ExtracellularSequence analysisAdd BLAST11
Transmembranei219 – 239HelicalSequence analysisAdd BLAST21
Topological domaini240 – 374CytoplasmicSequence analysisAdd BLAST135

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Involvement in diseasei

Birk-Barel mental retardation dysmorphism syndrome (BIBAS)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA syndrome characterized by mental retardation, hypotonia, hyperactivity, and facial dysmorphism.
See also OMIM:612292
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_054373236G → R in BIBAS; inactive. 1 PublicationCorresponds to variant dbSNP:rs121908332Ensembl.1

Keywords - Diseasei

Disease mutation, Mental retardation

Organism-specific databases

DisGeNETi51305
MalaCardsiKCNK9
MIMi612292 phenotype
OpenTargetsiENSG00000169427
Orphaneti166108 Intellectual disability, Birk-Barel type
PharmGKBiPA30065

Chemistry databases

ChEMBLiCHEMBL2321614
DrugBankiDB00561 Doxapram
DB01159 Halothane

Polymorphism and mutation databases

DMDMi13431426

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001017541 – 374Potassium channel subfamily K member 9Add BLAST374

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi53N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9NPC2
PeptideAtlasiQ9NPC2
PRIDEiQ9NPC2

PTM databases

iPTMnetiQ9NPC2
PhosphoSitePlusiQ9NPC2

Expressioni

Tissue specificityi

Mainly found in the cerebellum. Also found in adrenal gland, kidney and lung.2 Publications

Gene expression databases

BgeeiENSG00000169427
CleanExiHS_KCNK9
ExpressionAtlasiQ9NPC2 baseline and differential
GenevisibleiQ9NPC2 HS

Interactioni

Subunit structurei

Homodimer (Probable). Heterodimer with KCNK1.Curated1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi119456, 2 interactors
STRINGi9606.ENSP00000302166

Chemistry databases

BindingDBiQ9NPC2

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3P1NX-ray1.40P369-374[»]
3P1OX-ray1.90P369-374[»]
3P1PX-ray1.95P369-374[»]
3P1QX-ray1.70P369-374[»]
3P1RX-ray1.70P369-374[»]
3P1SX-ray1.65P369-374[»]
3SMKX-ray2.10P369-374[»]
3SMLX-ray1.90P370-374[»]
3SMMX-ray2.00P369-374[»]
3SMNX-ray2.00P369-374[»]
3SMOX-ray1.80P369-374[»]
3SP5X-ray1.80P369-374[»]
3SPRX-ray1.99P369-374[»]
3UX0X-ray1.75P369-374[»]
4FR3X-ray1.90P369-374[»]
ProteinModelPortaliQ9NPC2
SMRiQ9NPC2
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9NPC2

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4404 Eukaryota
ENOG410XRZJ LUCA
GeneTreeiENSGT00760000118858
HOGENOMiHOG000231463
HOVERGENiHBG052239
InParanoidiQ9NPC2
KOiK04919
OMAiGMRNTEV
OrthoDBiEOG091G08DH
PhylomeDBiQ9NPC2
TreeFamiTF313947

Family and domain databases

InterProiView protein in InterPro
IPR003280 2pore_dom_K_chnl
IPR003092 2pore_dom_K_chnl_TASK
IPR013099 K_chnl_dom
IPR005407 KCNK9
PfamiView protein in Pfam
PF07885 Ion_trans_2, 2 hits
PIRSFiPIRSF038061 K_channel_subfamily_K_type, 1 hit
PRINTSiPR01333 2POREKCHANEL
PR01585 TASK3CHANNEL
PR01095 TASKCHANNEL

Sequencei

Sequence statusi: Complete.

Q9NPC2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKRQNVRTLS LIVCTFTYLL VGAAVFDALE SDHEMREEEK LKAEEIRIKG
60 70 80 90 100
KYNISSEDYR QLELVILQSE PHRAGVQWKF AGSFYFAITV ITTIGYGHAA
110 120 130 140 150
PGTDAGKAFC MFYAVLGIPL TLVMFQSLGE RMNTFVRYLL KRIKKCCGMR
160 170 180 190 200
NTDVSMENMV TVGFFSCMGT LCIGAAAFSQ CEEWSFFHAY YYCFITLTTI
210 220 230 240 250
GFGDYVALQT KGALQKKPLY VAFSFMYILV GLTVIGAFLN LVVLRFLTMN
260 270 280 290 300
SEDERRDAEE RASLAGNRNS MVIHIPEEPR PSRPRYKADV PDLQSVCSCT
310 320 330 340 350
CYRSQDYGGR SVAPQNSFSA KLAPHYFHSI SYKIEEISPS TLKNSLFPSP
360 370
ISSISPGLHS FTDHQRLMKR RKSV
Length:374
Mass (Da):42,264
Last modified:October 1, 2000 - v1
Checksum:i8A19EAEE5A4D7F38
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_054373236G → R in BIBAS; inactive. 1 PublicationCorresponds to variant dbSNP:rs121908332Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF212829 mRNA Translation: AAF63708.1
AF248241 mRNA Translation: AAG31730.1
AF257080 mRNA Translation: AAG33126.1
AY190605 mRNA Translation: AAO38739.1
AF279809 mRNA Translation: AAF85982.1
BC075079 mRNA Translation: AAH75079.1
BC075080 mRNA Translation: AAH75080.1
BC112063 mRNA Translation: AAI12064.1
BC112065 mRNA Translation: AAI12066.1
CCDSiCCDS6377.1
RefSeqiNP_001269463.1, NM_001282534.1
XP_011515404.1, XM_011517102.2
UniGeneiHs.493037
Hs.553147
Hs.664608

Genome annotation databases

EnsembliENST00000303015; ENSP00000302166; ENSG00000169427
ENST00000520439; ENSP00000430676; ENSG00000169427
ENST00000522317; ENSP00000429847; ENSG00000169427
GeneIDi51305
KEGGihsa:51305
UCSCiuc003yvg.3 human

Similar proteinsi

Entry informationi

Entry nameiKCNK9_HUMAN
AccessioniPrimary (citable) accession number: Q9NPC2
Secondary accession number(s): Q2M290, Q540F2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: October 1, 2000
Last modified: March 28, 2018
This is version 145 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
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Main funding by: National Institutes of Health