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Protein

Potassium channel subfamily K member 9

Gene

KCNK9

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

pH-dependent, voltage-insensitive, background potassium channel protein.2 Publications

GO - Molecular functioni

  1. potassium channel activity Source: UniProtKB-KW
  2. voltage-gated ion channel activity Source: UniProtKB-KW

GO - Biological processi

  1. cochlea development Source: Ensembl
  2. potassium ion transport Source: UniProtKB
  3. synaptic transmission Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Potassium channel, Voltage-gated channel

Keywords - Biological processi

Ion transport, Potassium transport, Transport

Keywords - Ligandi

Potassium

Enzyme and pathway databases

ReactomeiREACT_75899. TWIK-releated acid-sensitive K+ channel (TASK).

Names & Taxonomyi

Protein namesi
Recommended name:
Potassium channel subfamily K member 9
Alternative name(s):
Acid-sensitive potassium channel protein TASK-3
TWIK-related acid-sensitive K(+) channel 3
Two pore potassium channel KT3.2
Short name:
Two pore K(+) channel KT3.2
Gene namesi
Name:KCNK9
Synonyms:TASK3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 8

Organism-specific databases

HGNCiHGNC:6283. KCNK9.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 88CytoplasmicSequence Analysis
Transmembranei9 – 2921HelicalSequence AnalysisAdd
BLAST
Topological domaini30 – 8859ExtracellularSequence AnalysisAdd
BLAST
Intramembranei89 – 10113Pore-forming; Name=Pore-forming 1Sequence AnalysisAdd
BLAST
Topological domaini102 – 1076ExtracellularSequence Analysis
Transmembranei108 – 12821HelicalSequence AnalysisAdd
BLAST
Topological domaini129 – 15830CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei159 – 17921HelicalSequence AnalysisAdd
BLAST
Topological domaini180 – 19415ExtracellularSequence AnalysisAdd
BLAST
Intramembranei195 – 20713Pore-forming; Name=Pore-forming 2Sequence AnalysisAdd
BLAST
Topological domaini208 – 21811ExtracellularSequence AnalysisAdd
BLAST
Transmembranei219 – 23921HelicalSequence AnalysisAdd
BLAST
Topological domaini240 – 374135CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: Reactome
  3. synaptic vesicle Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Involvement in diseasei

Birk-Barel mental retardation dysmorphism syndrome (BIBAS)1 Publication

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionA syndrome characterized by mental retardation, hypotonia, hyperactivity, and facial dysmorphism.

See also OMIM:612292
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti236 – 2361G → R in BIBAS; inactive. 1 Publication
VAR_054373

Keywords - Diseasei

Disease mutation, Mental retardation

Organism-specific databases

MIMi612292. phenotype.
Orphaneti166108. Intellectual disability, Birk-Barel type.
PharmGKBiPA30065.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 374374Potassium channel subfamily K member 9PRO_0000101754Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi53 – 531N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9NPC2.
PRIDEiQ9NPC2.

PTM databases

PhosphoSiteiQ9NPC2.

Expressioni

Tissue specificityi

Mainly found in the cerebellum. Also found in adrenal gland, kidney and lung.2 Publications

Gene expression databases

BgeeiQ9NPC2.
CleanExiHS_KCNK9.
ExpressionAtlasiQ9NPC2. baseline and differential.
GenevestigatoriQ9NPC2.

Interactioni

Protein-protein interaction databases

BioGridi119456. 2 interactions.
STRINGi9606.ENSP00000302166.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3P1NX-ray1.40P369-374[»]
3P1OX-ray1.90P369-374[»]
3P1PX-ray1.95P369-374[»]
3P1QX-ray1.70P369-374[»]
3P1RX-ray1.70P369-374[»]
3P1SX-ray1.65P369-374[»]
3SMKX-ray2.10P369-374[»]
3SMLX-ray1.90P370-374[»]
3SMMX-ray2.00P369-374[»]
3SMNX-ray2.00P369-374[»]
3SMOX-ray1.80P369-374[»]
3SPRX-ray1.99P369-374[»]
3UX0X-ray1.75P369-374[»]
4FR3X-ray1.90P369-374[»]
ProteinModelPortaliQ9NPC2.
SMRiQ9NPC2. Positions 22-242.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9NPC2.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG259548.
GeneTreeiENSGT00760000118858.
HOGENOMiHOG000231463.
HOVERGENiHBG052239.
InParanoidiQ9NPC2.
KOiK04919.
OMAiMIIHIQD.
OrthoDBiEOG7B05DC.
PhylomeDBiQ9NPC2.
TreeFamiTF313947.

Family and domain databases

InterProiIPR003280. 2pore_dom_K_chnl.
IPR013099. 2pore_dom_K_chnl_dom.
IPR003092. 2pore_dom_K_chnl_TASK.
IPR005407. KCNK9.
[Graphical view]
PfamiPF07885. Ion_trans_2. 2 hits.
[Graphical view]
PIRSFiPIRSF038061. K_channel_subfamily_K_type. 1 hit.
PRINTSiPR01333. 2POREKCHANEL.
PR01585. TASK3CHANNEL.
PR01095. TASKCHANNEL.

Sequencei

Sequence statusi: Complete.

Q9NPC2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKRQNVRTLS LIVCTFTYLL VGAAVFDALE SDHEMREEEK LKAEEIRIKG
60 70 80 90 100
KYNISSEDYR QLELVILQSE PHRAGVQWKF AGSFYFAITV ITTIGYGHAA
110 120 130 140 150
PGTDAGKAFC MFYAVLGIPL TLVMFQSLGE RMNTFVRYLL KRIKKCCGMR
160 170 180 190 200
NTDVSMENMV TVGFFSCMGT LCIGAAAFSQ CEEWSFFHAY YYCFITLTTI
210 220 230 240 250
GFGDYVALQT KGALQKKPLY VAFSFMYILV GLTVIGAFLN LVVLRFLTMN
260 270 280 290 300
SEDERRDAEE RASLAGNRNS MVIHIPEEPR PSRPRYKADV PDLQSVCSCT
310 320 330 340 350
CYRSQDYGGR SVAPQNSFSA KLAPHYFHSI SYKIEEISPS TLKNSLFPSP
360 370
ISSISPGLHS FTDHQRLMKR RKSV
Length:374
Mass (Da):42,264
Last modified:September 30, 2000 - v1
Checksum:i8A19EAEE5A4D7F38
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti236 – 2361G → R in BIBAS; inactive. 1 Publication
VAR_054373

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF212829 mRNA. Translation: AAF63708.1.
AF248241 mRNA. Translation: AAG31730.1.
AF257080 mRNA. Translation: AAG33126.1.
AY190605 mRNA. Translation: AAO38739.1.
AF279809 mRNA. Translation: AAF85982.1.
BC075079 mRNA. Translation: AAH75079.1.
BC075080 mRNA. Translation: AAH75080.1.
BC112063 mRNA. Translation: AAI12064.1.
BC112065 mRNA. Translation: AAI12066.1.
CCDSiCCDS6377.1.
RefSeqiNP_001269463.1. NM_001282534.1.
UniGeneiHs.493037.
Hs.553147.
Hs.664608.

Genome annotation databases

EnsembliENST00000303015; ENSP00000302166; ENSG00000169427.
ENST00000520439; ENSP00000430676; ENSG00000169427.
ENST00000522317; ENSP00000429847; ENSG00000169427.
GeneIDi51305.
KEGGihsa:51305.
UCSCiuc003yvf.1. human.

Polymorphism databases

DMDMi13431426.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF212829 mRNA. Translation: AAF63708.1.
AF248241 mRNA. Translation: AAG31730.1.
AF257080 mRNA. Translation: AAG33126.1.
AY190605 mRNA. Translation: AAO38739.1.
AF279809 mRNA. Translation: AAF85982.1.
BC075079 mRNA. Translation: AAH75079.1.
BC075080 mRNA. Translation: AAH75080.1.
BC112063 mRNA. Translation: AAI12064.1.
BC112065 mRNA. Translation: AAI12066.1.
CCDSiCCDS6377.1.
RefSeqiNP_001269463.1. NM_001282534.1.
UniGeneiHs.493037.
Hs.553147.
Hs.664608.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3P1NX-ray1.40P369-374[»]
3P1OX-ray1.90P369-374[»]
3P1PX-ray1.95P369-374[»]
3P1QX-ray1.70P369-374[»]
3P1RX-ray1.70P369-374[»]
3P1SX-ray1.65P369-374[»]
3SMKX-ray2.10P369-374[»]
3SMLX-ray1.90P370-374[»]
3SMMX-ray2.00P369-374[»]
3SMNX-ray2.00P369-374[»]
3SMOX-ray1.80P369-374[»]
3SPRX-ray1.99P369-374[»]
3UX0X-ray1.75P369-374[»]
4FR3X-ray1.90P369-374[»]
ProteinModelPortaliQ9NPC2.
SMRiQ9NPC2. Positions 22-242.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119456. 2 interactions.
STRINGi9606.ENSP00000302166.

Chemistry

BindingDBiQ9NPC2.
ChEMBLiCHEMBL2321614.
DrugBankiDB00561. Doxapram.
DB01159. Halothane.
GuidetoPHARMACOLOGYi520.

PTM databases

PhosphoSiteiQ9NPC2.

Polymorphism databases

DMDMi13431426.

Proteomic databases

PaxDbiQ9NPC2.
PRIDEiQ9NPC2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000303015; ENSP00000302166; ENSG00000169427.
ENST00000520439; ENSP00000430676; ENSG00000169427.
ENST00000522317; ENSP00000429847; ENSG00000169427.
GeneIDi51305.
KEGGihsa:51305.
UCSCiuc003yvf.1. human.

Organism-specific databases

CTDi51305.
GeneCardsiGC08M140693.
HGNCiHGNC:6283. KCNK9.
MIMi605874. gene.
612292. phenotype.
neXtProtiNX_Q9NPC2.
Orphaneti166108. Intellectual disability, Birk-Barel type.
PharmGKBiPA30065.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG259548.
GeneTreeiENSGT00760000118858.
HOGENOMiHOG000231463.
HOVERGENiHBG052239.
InParanoidiQ9NPC2.
KOiK04919.
OMAiMIIHIQD.
OrthoDBiEOG7B05DC.
PhylomeDBiQ9NPC2.
TreeFamiTF313947.

Enzyme and pathway databases

ReactomeiREACT_75899. TWIK-releated acid-sensitive K+ channel (TASK).

Miscellaneous databases

ChiTaRSiKCNK9. human.
EvolutionaryTraceiQ9NPC2.
GeneWikiiKCNK9.
GenomeRNAii51305.
NextBioi54617.
PROiQ9NPC2.
SOURCEiSearch...

Gene expression databases

BgeeiQ9NPC2.
CleanExiHS_KCNK9.
ExpressionAtlasiQ9NPC2. baseline and differential.
GenevestigatoriQ9NPC2.

Family and domain databases

InterProiIPR003280. 2pore_dom_K_chnl.
IPR013099. 2pore_dom_K_chnl_dom.
IPR003092. 2pore_dom_K_chnl_TASK.
IPR005407. KCNK9.
[Graphical view]
PfamiPF07885. Ion_trans_2. 2 hits.
[Graphical view]
PIRSFiPIRSF038061. K_channel_subfamily_K_type. 1 hit.
PRINTSiPR01333. 2POREKCHANEL.
PR01585. TASK3CHANNEL.
PR01095. TASKCHANNEL.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "TASK-3, a novel tandem pore domain acid-sensitive K+ channel. An extracellular histidine as pH sensor."
    Rajan S., Wischmeyer E., Liu G.X., Preisig-Mueller R., Daut J., Karschin A., Derst C.
    J. Biol. Chem. 275:16650-16657(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Cloning, localisation and functional expression of a novel human, cerebellum specific, two pore domain potassium channel."
    Chapman C.G., Meadows H.J., Godden R.J., Campbell D.A., Duckworth M., Kelsell R.E., Murdock P.R., Randall A.D., Rennie G.I., Gloger I.S.
    Brain Res. Mol. Brain Res. 82:74-83(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
    Tissue: Cerebellum.
  3. "KT3.2 and KT3.3, two novel human two-pore K(+) channels closely related to TASK-1."
    Vega-Saenz de Miera E., Lau D.H.P., Zhadina M., Pountney D., Coetzee W.A., Rudy B.
    J. Neurophysiol. 86:130-142(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
  4. Cited for: NUCLEOTIDE SEQUENCE [MRNA], OVEREXPRESSION IN BREAST CANCERS.
  5. "Human Task-3, a novel 2P domain potassium channel related to Task."
    Girard C., Lesage F., Tinel N., Lazdunski M.
    Submitted (MAY-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  7. "Maternally inherited Birk Barel mental retardation dysmorphism syndrome caused by a mutation in the genomically imprinted potassium channel KCNK9."
    Barel O., Shalev S.A., Ofir R., Cohen A., Zlotogora J., Shorer Z., Mazor G., Finer G., Khateeb S., Zilberberg N., Birk O.S.
    Am. J. Hum. Genet. 83:193-199(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT BIBAS ARG-236, CHARACTERIZATION OF VARIANT BIBAS ARG-236.

Entry informationi

Entry nameiKCNK9_HUMAN
AccessioniPrimary (citable) accession number: Q9NPC2
Secondary accession number(s): Q2M290, Q540F2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2001
Last sequence update: September 30, 2000
Last modified: January 6, 2015
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Inhibited by phorbol 12-myristate 13-acetate (PMA). TASK-3 current is strongly decreased in the presence of an extracellular pH inferior to 7.0.
Overexpressed in a high proportion of breast cancers. May confer resistance to growth factor deprivation and hypoxia, thereby promoting tumor cell survival in poorly oxygenated areas of solid tumors.

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.