ID   LT4R2_HUMAN             Reviewed;         358 AA.
AC   Q9NPC1; Q5KU28; Q9NPE5;
DT   10-OCT-2002, integrated into UniProtKB/Swiss-Prot.
DT   13-FEB-2019, sequence version 2.
DT   24-JAN-2024, entry version 184.
DE   RecName: Full=Leukotriene B4 receptor 2;
DE            Short=LTB4-R 2;
DE            Short=LTB4-R2;
DE   AltName: Full=LTB4 receptor JULF2;
DE   AltName: Full=Leukotriene B4 receptor BLT2;
DE   AltName: Full=Seven transmembrane receptor BLTR2;
GN   Name=LTB4R2; Synonyms=BLT2R, BLTR2;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=10913346; DOI=10.1006/bbrc.2000.3152;
RA   Tryselius Y., Nilsson N.E., Kotarsky K., Olde B., Owman C.;
RT   "Cloning and characterization of cDNA encoding a novel human leukotriene B4
RT   receptor.";
RL   Biochem. Biophys. Res. Commun. 274:377-382(2000).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=10889186; DOI=10.1074/jbc.c000382200;
RA   Kamohara M., Takasaki J., Matsumoto M., Saito T., Ohishi T., Ishii H.,
RA   Furuichi K.;
RT   "Molecular cloning and characterization of another leukotriene B4
RT   receptor.";
RL   J. Biol. Chem. 275:27000-27004(2000).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=11006272; DOI=10.1074/jbc.m004512200;
RA   Wang S., Gustafson E., Pang L., Qiao X., Behan J., Maguire M., Bayne M.,
RA   Laz T.;
RT   "A novel hepatointestinal leukotriene B4 receptor: cloning and functional
RT   characterization.";
RL   J. Biol. Chem. 275:40686-40694(2000).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
RX   PubMed=10934230; DOI=10.1084/jem.192.3.421;
RA   Yokomizo T., Kato K., Terawaki K., Izumi T., Shimizu T.;
RT   "A second leukotriene B4 receptor, BLT2: a new therapeutic target in
RT   inflammation and immunological disorders.";
RL   J. Exp. Med. 192:421-432(2000).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=12044878; DOI=10.1016/s0014-5793(02)02775-8;
RA   Takeda S., Kadowaki S., Haga T., Takaesu H., Mitaku S.;
RT   "Identification of G protein-coupled receptor genes from the human genome
RT   sequence.";
RL   FEBS Lett. 520:97-101(2002).
RN   [6]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Hirose M., Urakawa I., Yamano S., Okazaki H.;
RT   "Probable G-protein coupled receptor.";
RL   Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases.
RN   [7]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Volpe F., Patel K., Barnes A., Sanseau P., Cousens D., Green A.,
RA   Marshall F.;
RT   "Identification and characterisation of a novel LTB4 receptor.";
RL   Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases.
RN   [8]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA   Kopatz S.A., Aronstam R.S., Sharma S.V.;
RT   "cDNA clones of human proteins involved in signal transduction sequenced by
RT   the Guthrie cDNA resource center (www.cdna.org).";
RL   Submitted (APR-2003) to the EMBL/GenBank/DDBJ databases.
RN   [9]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=12508121; DOI=10.1038/nature01348;
RA   Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C.,
RA   Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A.,
RA   Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H.,
RA   Du H., Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T.,
RA   Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B.,
RA   Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D.,
RA   Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R.,
RA   Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S.,
RA   Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C.,
RA   Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S.,
RA   Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C.,
RA   Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P.,
RA   Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M.,
RA   Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V.,
RA   Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J.,
RA   Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F.,
RA   Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F.,
RA   Waterston R., Hood L., Weissenbach J.;
RT   "The DNA sequence and analysis of human chromosome 14.";
RL   Nature 421:601-607(2003).
RN   [10]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Low-affinity receptor for leukotrienes including leukotriene
CC       B4. Mediates chemotaxis of granulocytes and macrophages. The response
CC       is mediated via G-proteins that activate a phosphatidylinositol-calcium
CC       second messenger system. The rank order of affinities for the
CC       leukotrienes is LTB4 > 12-epi-LTB4 > LTB5 > LTB3.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- TISSUE SPECIFICITY: Widely expressed.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAF81261.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
CC       Sequence=AAP23200.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC       Sequence=CAB96134.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; AF277230; AAF81261.1; ALT_INIT; mRNA.
DR   EMBL; AB044402; BAA99539.1; -; mRNA.
DR   EMBL; AF308571; AAG40857.1; -; mRNA.
DR   EMBL; AB008193; BAB00610.1; -; Genomic_DNA.
DR   EMBL; AB029892; BAA99553.1; -; mRNA.
DR   EMBL; AB083604; BAB89317.1; -; Genomic_DNA.
DR   EMBL; AB032558; BAD83590.1; -; mRNA.
DR   EMBL; AJ278605; CAB96134.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; AY268433; AAP23200.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; AL096870; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CH471078; EAW66030.1; -; Genomic_DNA.
DR   CCDS; CCDS9625.2; -.
DR   PIR; JC7356; JC7356.
DR   RefSeq; NP_001158164.1; NM_001164692.2.
DR   RefSeq; NP_062813.2; NM_019839.4.
DR   AlphaFoldDB; Q9NPC1; -.
DR   SMR; Q9NPC1; -.
DR   BioGRID; 121143; 49.
DR   IntAct; Q9NPC1; 46.
DR   MINT; Q9NPC1; -.
DR   STRING; 9606.ENSP00000445772; -.
DR   BindingDB; Q9NPC1; -.
DR   ChEMBL; CHEMBL3191; -.
DR   DrugBank; DB06248; Amelubant.
DR   DrugBank; DB12961; Leukotriene B4.
DR   GuidetoPHARMACOLOGY; 268; -.
DR   SwissLipids; SLP:000001556; -.
DR   GlyCosmos; Q9NPC1; 1 site, No reported glycans.
DR   GlyGen; Q9NPC1; 1 site.
DR   iPTMnet; Q9NPC1; -.
DR   PhosphoSitePlus; Q9NPC1; -.
DR   BioMuta; LTB4R2; -.
DR   DMDM; 23821812; -.
DR   EPD; Q9NPC1; -.
DR   MassIVE; Q9NPC1; -.
DR   PaxDb; 9606-ENSP00000445772; -.
DR   PeptideAtlas; Q9NPC1; -.
DR   Antibodypedia; 9159; 249 antibodies from 28 providers.
DR   DNASU; 56413; -.
DR   Ensembl; ENST00000533293.2; ENSP00000433290.1; ENSG00000213906.10.
DR   Ensembl; ENST00000543919.1; ENSP00000445772.1; ENSG00000213906.10.
DR   Ensembl; ENST00000643080.1; ENSP00000494694.1; ENSG00000285203.2.
DR   Ensembl; ENST00000644309.2; ENSP00000494877.1; ENSG00000285203.2.
DR   GeneID; 56413; -.
DR   KEGG; hsa:56413; -.
DR   MANE-Select; ENST00000533293.2; ENSP00000433290.1; NM_019839.5; NP_062813.2.
DR   UCSC; uc001wor.4; human.
DR   AGR; HGNC:19260; -.
DR   CTD; 56413; -.
DR   DisGeNET; 56413; -.
DR   GeneCards; LTB4R2; -.
DR   HGNC; HGNC:19260; LTB4R2.
DR   HPA; ENSG00000213906; Tissue enhanced (esophagus, skin).
DR   MIM; 605773; gene.
DR   neXtProt; NX_Q9NPC1; -.
DR   OpenTargets; ENSG00000213906; -.
DR   PharmGKB; PA134910672; -.
DR   VEuPathDB; HostDB:ENSG00000213906; -.
DR   eggNOG; KOG3656; Eukaryota.
DR   GeneTree; ENSGT00950000182966; -.
DR   InParanoid; Q9NPC1; -.
DR   OMA; FIAQFFE; -.
DR   OrthoDB; 5390060at2759; -.
DR   PhylomeDB; Q9NPC1; -.
DR   TreeFam; TF330976; -.
DR   PathwayCommons; Q9NPC1; -.
DR   Reactome; R-HSA-391906; Leukotriene receptors.
DR   Reactome; R-HSA-416476; G alpha (q) signalling events.
DR   SignaLink; Q9NPC1; -.
DR   SIGNOR; Q9NPC1; -.
DR   BioGRID-ORCS; 56413; 127 hits in 1152 CRISPR screens.
DR   GenomeRNAi; 56413; -.
DR   Pharos; Q9NPC1; Tchem.
DR   PRO; PR:Q9NPC1; -.
DR   Proteomes; UP000005640; Chromosome 14.
DR   RNAct; Q9NPC1; Protein.
DR   Bgee; ENSG00000213906; Expressed in skin of abdomen and 95 other cell types or tissues.
DR   ExpressionAtlas; Q9NPC1; baseline and differential.
DR   GO; GO:0016020; C:membrane; HDA:UniProtKB.
DR   GO; GO:0005654; C:nucleoplasm; IDA:HPA.
DR   GO; GO:0005886; C:plasma membrane; IDA:HPA.
DR   GO; GO:0008528; F:G protein-coupled peptide receptor activity; IBA:GO_Central.
DR   GO; GO:0001632; F:leukotriene B4 receptor activity; IBA:GO_Central.
DR   GO; GO:0004974; F:leukotriene receptor activity; TAS:ProtInc.
DR   GO; GO:0006935; P:chemotaxis; TAS:ProtInc.
DR   GO; GO:0051546; P:keratinocyte migration; IEA:Ensembl.
DR   GO; GO:0007194; P:negative regulation of adenylate cyclase activity; TAS:ProtInc.
DR   GO; GO:0007218; P:neuropeptide signaling pathway; IBA:GO_Central.
DR   Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   InterPro; IPR003981; Leukotriene_B4_rcpt.
DR   InterPro; IPR003982; Leukotriene_B4_typ-2_rcpt.
DR   PANTHER; PTHR24230; G-PROTEIN COUPLED RECEPTOR; 1.
DR   PANTHER; PTHR24230:SF8; LEUKOTRIENE B4 RECEPTOR 2; 1.
DR   Pfam; PF00001; 7tm_1; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PRINTS; PR01478; LTB2RECEPTOR.
DR   PRINTS; PR01476; LTBRECEPTOR.
DR   SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
DR   Genevisible; Q9NPC1; HS.
PE   2: Evidence at transcript level;
KW   Cell membrane; G-protein coupled receptor; Glycoprotein; Membrane;
KW   Receptor; Reference proteome; Transducer; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..358
FT                   /note="Leukotriene B4 receptor 2"
FT                   /id="PRO_0000069711"
FT   TOPO_DOM        1..24
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        25..45
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        46..60
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        61..81
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        82..96
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        97..117
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        118..140
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        141..161
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        162..185
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        186..206
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        207..224
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        225..245
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        246..275
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        276..296
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        297..358
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   REGION          311..358
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        10
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   358 AA;  37942 MW;  5F5D98179CE00F3D CRC64;
     MSVCYRPPGN ETLLSWKTSR ATGTAFLLLA ALLGLPGNGF VVWSLAGWRP ARGRPLAATL
     VLHLALADGA VLLLTPLFVA FLTRQAWPLG QAGCKAVYYV CALSMYASVL LTGLLSLQRC
     LAVTRPFLAP RLRSPALARR LLLAVWLAAL LLAVPAAVYR HLWRDRVCQL CHPSPVHAAA
     HLSLETLTAF VLPFGLMLGC YSVTLARLRG ARWGSGRHGA RVGRLVSAIV LAFGLLWAPY
     HAVNLLQAVA ALAPPEGALA KLGGAGQAAR AGTTALAFFS SSVNPVLYVF TAGDLLPRAG
     PRFLTRLFEG SGEARGGGRS REGTMELRTT PQLKVVGQGR GNGDPGGGME KDGPEWDL
//