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Protein

Leukotriene B4 receptor 2

Gene

LTB4R2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Low-affinity receptor for leukotrienes including leukotriene B4. Mediates chemotaxis of granulocytes and macrophages. The response is mediated via G-proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinities for the leukotrienes is LTB4 > 12-epi-LTB4 > LTB5 > LTB3.

GO - Molecular functioni

  • leukotriene B4 receptor activity Source: Ensembl
  • leukotriene receptor activity Source: ProtInc

GO - Biological processi

  • chemotaxis Source: ProtInc
  • keratinocyte migration Source: Ensembl
  • negative regulation of adenylate cyclase activity Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiREACT_18283. G alpha (q) signalling events.
REACT_18302. Leukotriene receptors.

Names & Taxonomyi

Protein namesi
Recommended name:
Leukotriene B4 receptor 2
Short name:
LTB4-R 2
Short name:
LTB4-R2
Alternative name(s):
LTB4 receptor JULF2
Leukotriene B4 receptor BLT2
Seven transmembrane receptor BLTR2
Gene namesi
Name:LTB4R2
Synonyms:BLT2R, BLTR2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 14

Organism-specific databases

HGNCiHGNC:19260. LTB4R2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 5555ExtracellularSequence AnalysisAdd
BLAST
Transmembranei56 – 7621Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini77 – 9115CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei92 – 11221Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini113 – 12715ExtracellularSequence AnalysisAdd
BLAST
Transmembranei128 – 14821Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini149 – 17224CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei173 – 19321Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini194 – 21623ExtracellularSequence AnalysisAdd
BLAST
Transmembranei217 – 23721Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini238 – 25619CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei257 – 27721Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini278 – 30629ExtracellularSequence AnalysisAdd
BLAST
Transmembranei307 – 32721Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini328 – 38962CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  • integral component of plasma membrane Source: ProtInc
  • membrane Source: UniProtKB
  • plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134910672.

Polymorphism and mutation databases

BioMutaiLTB4R2.
DMDMi23821812.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 389389Leukotriene B4 receptor 2PRO_0000069711Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi41 – 411N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9NPC1.
PRIDEiQ9NPC1.

PTM databases

PhosphoSiteiQ9NPC1.

Expressioni

Tissue specificityi

Widely expressed.

Gene expression databases

BgeeiQ9NPC1.
CleanExiHS_LTB4R2.
ExpressionAtlasiQ9NPC1. baseline.
GenevisibleiQ9NPC1. HS.

Organism-specific databases

HPAiCAB022689.
HPA029680.

Interactioni

Protein-protein interaction databases

BioGridi121143. 1 interaction.
IntActiQ9NPC1. 1 interaction.
MINTiMINT-8247212.
STRINGi9606.ENSP00000433290.

Structurei

3D structure databases

ProteinModelPortaliQ9NPC1.
SMRiQ9NPC1. Positions 55-321.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG308968.
GeneTreeiENSGT00760000118990.
HOGENOMiHOG000008594.
HOVERGENiHBG104134.
InParanoidiQ9NPC1.
KOiK04297.
OMAiSREGTME.
PhylomeDBiQ9NPC1.
TreeFamiTF330976.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR003981. Leukotriene_B4_rcpt.
IPR003982. Leukotriene_B4_typ-2_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01478. LTB2RECEPTOR.
PR01476. LTBRECEPTOR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9NPC1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAPSHRASQV GFCPTPERPL WRLPPTCRPR RMSVCYRPPG NETLLSWKTS
60 70 80 90 100
RATGTAFLLL AALLGLPGNG FVVWSLAGWR PARGRPLAAT LVLHLALADG
110 120 130 140 150
AVLLLTPLFV AFLTRQAWPL GQAGCKAVYY VCALSMYASV LLTGLLSLQR
160 170 180 190 200
CLAVTRPFLA PRLRSPALAR RLLLAVWLAA LLLAVPAAVY RHLWRDRVCQ
210 220 230 240 250
LCHPSPVHAA AHLSLETLTA FVLPFGLMLG CYSVTLARLR GARWGSGRHG
260 270 280 290 300
ARVGRLVSAI VLAFGLLWAP YHAVNLLQAV AALAPPEGAL AKLGGAGQAA
310 320 330 340 350
RAGTTALAFF SSSVNPVLYV FTAGDLLPRA GPRFLTRLFE GSGEARGGGR
360 370 380
SREGTMELRT TPQLKVVGQG RGNGDPGGGM EKDGPEWDL
Length:389
Mass (Da):41,525
Last modified:October 1, 2000 - v1
Checksum:i8D6BC5A73A42F544
GO
Isoform 2 (identifier: Q9NPC1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-31: Missing.

Note: No experimental confirmation available.
Show »
Length:358
Mass (Da):37,942
Checksum:i5F5D98179CE00F3D
GO

Sequence cautioni

The sequence BAB00610.1 differs from that shown. Reason: Erroneous initiation. Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 3131Missing in isoform 2. 1 PublicationVSP_044885Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF277230 mRNA. Translation: AAF81261.1.
AB029892 mRNA. Translation: BAA99553.1.
AB008193 Genomic DNA. Translation: BAB00610.1. Different initiation.
AB032558 mRNA. Translation: BAD83590.1.
AJ278605 Genomic DNA. Translation: CAB96134.1.
AY268433 Genomic DNA. Translation: AAP23200.1.
AL096870 Genomic DNA. No translation available.
CH471078 Genomic DNA. Translation: EAW66030.1.
AF308571 mRNA. Translation: AAG40857.1.
AB044402 mRNA. Translation: BAA99539.1.
AB083604 Genomic DNA. Translation: BAB89317.1.
CCDSiCCDS9625.2. [Q9NPC1-2]
PIRiJC7356.
RefSeqiNP_001158164.1. NM_001164692.2. [Q9NPC1-2]
NP_062813.2. NM_019839.4. [Q9NPC1-2]
UniGeneiHs.642693.
Hs.657595.

Genome annotation databases

EnsembliENST00000528054; ENSP00000432146; ENSG00000213906. [Q9NPC1-1]
ENST00000533293; ENSP00000433290; ENSG00000213906. [Q9NPC1-2]
ENST00000543919; ENSP00000445772; ENSG00000213906. [Q9NPC1-2]
GeneIDi56413.
KEGGihsa:56413.
UCSCiuc001wor.3. human. [Q9NPC1-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF277230 mRNA. Translation: AAF81261.1.
AB029892 mRNA. Translation: BAA99553.1.
AB008193 Genomic DNA. Translation: BAB00610.1. Different initiation.
AB032558 mRNA. Translation: BAD83590.1.
AJ278605 Genomic DNA. Translation: CAB96134.1.
AY268433 Genomic DNA. Translation: AAP23200.1.
AL096870 Genomic DNA. No translation available.
CH471078 Genomic DNA. Translation: EAW66030.1.
AF308571 mRNA. Translation: AAG40857.1.
AB044402 mRNA. Translation: BAA99539.1.
AB083604 Genomic DNA. Translation: BAB89317.1.
CCDSiCCDS9625.2. [Q9NPC1-2]
PIRiJC7356.
RefSeqiNP_001158164.1. NM_001164692.2. [Q9NPC1-2]
NP_062813.2. NM_019839.4. [Q9NPC1-2]
UniGeneiHs.642693.
Hs.657595.

3D structure databases

ProteinModelPortaliQ9NPC1.
SMRiQ9NPC1. Positions 55-321.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121143. 1 interaction.
IntActiQ9NPC1. 1 interaction.
MINTiMINT-8247212.
STRINGi9606.ENSP00000433290.

Chemistry

BindingDBiQ9NPC1.
ChEMBLiCHEMBL2095160.
GuidetoPHARMACOLOGYi268.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSiteiQ9NPC1.

Polymorphism and mutation databases

BioMutaiLTB4R2.
DMDMi23821812.

Proteomic databases

PaxDbiQ9NPC1.
PRIDEiQ9NPC1.

Protocols and materials databases

DNASUi56413.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000528054; ENSP00000432146; ENSG00000213906. [Q9NPC1-1]
ENST00000533293; ENSP00000433290; ENSG00000213906. [Q9NPC1-2]
ENST00000543919; ENSP00000445772; ENSG00000213906. [Q9NPC1-2]
GeneIDi56413.
KEGGihsa:56413.
UCSCiuc001wor.3. human. [Q9NPC1-1]

Organism-specific databases

CTDi56413.
GeneCardsiGC14P024778.
GC14P024789.
H-InvDBHIX0131234.
HGNCiHGNC:19260. LTB4R2.
HPAiCAB022689.
HPA029680.
MIMi605773. gene.
neXtProtiNX_Q9NPC1.
PharmGKBiPA134910672.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG308968.
GeneTreeiENSGT00760000118990.
HOGENOMiHOG000008594.
HOVERGENiHBG104134.
InParanoidiQ9NPC1.
KOiK04297.
OMAiSREGTME.
PhylomeDBiQ9NPC1.
TreeFamiTF330976.

Enzyme and pathway databases

ReactomeiREACT_18283. G alpha (q) signalling events.
REACT_18302. Leukotriene receptors.

Miscellaneous databases

GenomeRNAii56413.
NextBioi61997.
PROiQ9NPC1.
SOURCEiSearch...

Gene expression databases

BgeeiQ9NPC1.
CleanExiHS_LTB4R2.
ExpressionAtlasiQ9NPC1. baseline.
GenevisibleiQ9NPC1. HS.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR003981. Leukotriene_B4_rcpt.
IPR003982. Leukotriene_B4_typ-2_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01478. LTB2RECEPTOR.
PR01476. LTBRECEPTOR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and characterization of cDNA encoding a novel human leukotriene B4 receptor."
    Tryselius Y., Nilsson N.E., Kotarsky K., Olde B., Owman C.
    Biochem. Biophys. Res. Commun. 274:377-382(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "A second leukotriene B4 receptor, BLT2: a new therapeutic target in inflammation and immunological disorders."
    Yokomizo T., Kato K., Terawaki K., Izumi T., Shimizu T.
    J. Exp. Med. 192:421-432(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  3. "Probable G-protein coupled receptor."
    Hirose M., Urakawa I., Yamano S., Okazaki H.
    Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
  4. "Identification and characterisation of a novel LTB4 receptor."
    Volpe F., Patel K., Barnes A., Sanseau P., Cousens D., Green A., Marshall F.
    Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  5. "cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
    Kopatz S.A., Aronstam R.S., Sharma S.V.
    Submitted (APR-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  6. "The DNA sequence and analysis of human chromosome 14."
    Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H.
    , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J.
    Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  8. "A novel hepatointestinal leukotriene B4 receptor: cloning and functional characterization."
    Wang S., Gustafson E., Pang L., Qiao X., Behan J., Maguire M., Bayne M., Laz T.
    J. Biol. Chem. 275:40686-40694(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 32-389 (ISOFORM 1).
  9. "Molecular cloning and characterization of another leukotriene B4 receptor."
    Kamohara M., Takasaki J., Matsumoto M., Saito T., Ohishi T., Ishii H., Furuichi K.
    J. Biol. Chem. 275:27000-27004(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 32-389 (ISOFORM 1).
  10. "Identification of G protein-coupled receptor genes from the human genome sequence."
    Takeda S., Kadowaki S., Haga T., Takaesu H., Mitaku S.
    FEBS Lett. 520:97-101(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] OF 32-389.

Entry informationi

Entry nameiLT4R2_HUMAN
AccessioniPrimary (citable) accession number: Q9NPC1
Secondary accession number(s): Q5KU28, Q9NPE5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2002
Last sequence update: October 1, 2000
Last modified: June 24, 2015
This is version 131 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-32 is the initiator.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.