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Q9NPC1

- LT4R2_HUMAN

UniProt

Q9NPC1 - LT4R2_HUMAN

Protein

Leukotriene B4 receptor 2

Gene

LTB4R2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 125 (01 Oct 2014)
      Sequence version 1 (01 Oct 2000)
      Previous versions | rss
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    Functioni

    Low-affinity receptor for leukotrienes including leukotriene B4. Mediates chemotaxis of granulocytes and macrophages. The response is mediated via G-proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinities for the leukotrienes is LTB4 > 12-epi-LTB4 > LTB5 > LTB3.

    GO - Molecular functioni

    1. leukotriene receptor activity Source: ProtInc

    GO - Biological processi

    1. chemotaxis Source: ProtInc
    2. negative regulation of adenylate cyclase activity Source: ProtInc

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Enzyme and pathway databases

    ReactomeiREACT_18283. G alpha (q) signalling events.
    REACT_18302. Leukotriene receptors.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leukotriene B4 receptor 2
    Short name:
    LTB4-R 2
    Short name:
    LTB4-R2
    Alternative name(s):
    LTB4 receptor JULF2
    Leukotriene B4 receptor BLT2
    Seven transmembrane receptor BLTR2
    Gene namesi
    Name:LTB4R2
    Synonyms:BLT2R, BLTR2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 14

    Organism-specific databases

    HGNCiHGNC:19260. LTB4R2.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of plasma membrane Source: ProtInc
    2. membrane Source: UniProtKB
    3. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134910672.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 389389Leukotriene B4 receptor 2PRO_0000069711Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi41 – 411N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiQ9NPC1.
    PRIDEiQ9NPC1.

    PTM databases

    PhosphoSiteiQ9NPC1.

    Expressioni

    Tissue specificityi

    Widely expressed.

    Gene expression databases

    BgeeiQ9NPC1.
    CleanExiHS_LTB4R2.
    GenevestigatoriQ9NPC1.

    Organism-specific databases

    HPAiCAB022689.
    HPA029680.

    Interactioni

    Protein-protein interaction databases

    BioGridi121143. 1 interaction.
    IntActiQ9NPC1. 1 interaction.
    MINTiMINT-8247212.
    STRINGi9606.ENSP00000337731.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9NPC1.
    SMRiQ9NPC1. Positions 55-321.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 5555ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini77 – 9115CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini113 – 12715ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini149 – 17224CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini194 – 21623ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini238 – 25619CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini278 – 30629ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini328 – 38962CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei56 – 7621Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei92 – 11221Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei128 – 14821Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei173 – 19321Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei217 – 23721Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei257 – 27721Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei307 – 32721Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG308968.
    HOGENOMiHOG000008594.
    HOVERGENiHBG104134.
    InParanoidiQ9NPC1.
    KOiK04297.
    OMAiPRAGPRF.
    PhylomeDBiQ9NPC1.
    TreeFamiTF330976.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR003981. Leukotriene_B4_rcpt.
    IPR003982. Leukotriene_B4_typ-2_rcpt.
    [Graphical view]
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR01478. LTB2RECEPTOR.
    PR01476. LTBRECEPTOR.
    PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9NPC1-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAPSHRASQV GFCPTPERPL WRLPPTCRPR RMSVCYRPPG NETLLSWKTS    50
    RATGTAFLLL AALLGLPGNG FVVWSLAGWR PARGRPLAAT LVLHLALADG 100
    AVLLLTPLFV AFLTRQAWPL GQAGCKAVYY VCALSMYASV LLTGLLSLQR 150
    CLAVTRPFLA PRLRSPALAR RLLLAVWLAA LLLAVPAAVY RHLWRDRVCQ 200
    LCHPSPVHAA AHLSLETLTA FVLPFGLMLG CYSVTLARLR GARWGSGRHG 250
    ARVGRLVSAI VLAFGLLWAP YHAVNLLQAV AALAPPEGAL AKLGGAGQAA 300
    RAGTTALAFF SSSVNPVLYV FTAGDLLPRA GPRFLTRLFE GSGEARGGGR 350
    SREGTMELRT TPQLKVVGQG RGNGDPGGGM EKDGPEWDL 389
    Length:389
    Mass (Da):41,525
    Last modified:October 1, 2000 - v1
    Checksum:i8D6BC5A73A42F544
    GO
    Isoform 2 (identifier: Q9NPC1-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-31: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:358
    Mass (Da):37,942
    Checksum:i5F5D98179CE00F3D
    GO

    Sequence cautioni

    The sequence BAB00610.1 differs from that shown. Reason: Erroneous initiation.

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 3131Missing in isoform 2. 1 PublicationVSP_044885Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF277230 mRNA. Translation: AAF81261.1.
    AB029892 mRNA. Translation: BAA99553.1.
    AB008193 Genomic DNA. Translation: BAB00610.1. Different initiation.
    AB032558 mRNA. Translation: BAD83590.1.
    AJ278605 Genomic DNA. Translation: CAB96134.1.
    AY268433 Genomic DNA. Translation: AAP23200.1.
    AL096870 Genomic DNA. No translation available.
    CH471078 Genomic DNA. Translation: EAW66030.1.
    AF308571 mRNA. Translation: AAG40857.1.
    AB044402 mRNA. Translation: BAA99539.1.
    AB083604 Genomic DNA. Translation: BAB89317.1.
    CCDSiCCDS9625.2. [Q9NPC1-2]
    PIRiJC7356.
    RefSeqiNP_001158164.1. NM_001164692.2. [Q9NPC1-2]
    NP_062813.2. NM_019839.4. [Q9NPC1-2]
    UniGeneiHs.642693.
    Hs.657595.

    Genome annotation databases

    EnsembliENST00000528054; ENSP00000432146; ENSG00000213906. [Q9NPC1-1]
    ENST00000533293; ENSP00000433290; ENSG00000213906. [Q9NPC1-2]
    ENST00000543919; ENSP00000445772; ENSG00000213906. [Q9NPC1-2]
    GeneIDi56413.
    KEGGihsa:56413.
    UCSCiuc001wor.3. human. [Q9NPC1-1]

    Polymorphism databases

    DMDMi23821812.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF277230 mRNA. Translation: AAF81261.1 .
    AB029892 mRNA. Translation: BAA99553.1 .
    AB008193 Genomic DNA. Translation: BAB00610.1 . Different initiation.
    AB032558 mRNA. Translation: BAD83590.1 .
    AJ278605 Genomic DNA. Translation: CAB96134.1 .
    AY268433 Genomic DNA. Translation: AAP23200.1 .
    AL096870 Genomic DNA. No translation available.
    CH471078 Genomic DNA. Translation: EAW66030.1 .
    AF308571 mRNA. Translation: AAG40857.1 .
    AB044402 mRNA. Translation: BAA99539.1 .
    AB083604 Genomic DNA. Translation: BAB89317.1 .
    CCDSi CCDS9625.2. [Q9NPC1-2 ]
    PIRi JC7356.
    RefSeqi NP_001158164.1. NM_001164692.2. [Q9NPC1-2 ]
    NP_062813.2. NM_019839.4. [Q9NPC1-2 ]
    UniGenei Hs.642693.
    Hs.657595.

    3D structure databases

    ProteinModelPortali Q9NPC1.
    SMRi Q9NPC1. Positions 55-321.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 121143. 1 interaction.
    IntActi Q9NPC1. 1 interaction.
    MINTi MINT-8247212.
    STRINGi 9606.ENSP00000337731.

    Chemistry

    BindingDBi Q9NPC1.
    ChEMBLi CHEMBL3191.
    GuidetoPHARMACOLOGYi 268.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei Q9NPC1.

    Polymorphism databases

    DMDMi 23821812.

    Proteomic databases

    PaxDbi Q9NPC1.
    PRIDEi Q9NPC1.

    Protocols and materials databases

    DNASUi 56413.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000528054 ; ENSP00000432146 ; ENSG00000213906 . [Q9NPC1-1 ]
    ENST00000533293 ; ENSP00000433290 ; ENSG00000213906 . [Q9NPC1-2 ]
    ENST00000543919 ; ENSP00000445772 ; ENSG00000213906 . [Q9NPC1-2 ]
    GeneIDi 56413.
    KEGGi hsa:56413.
    UCSCi uc001wor.3. human. [Q9NPC1-1 ]

    Organism-specific databases

    CTDi 56413.
    GeneCardsi GC14P024778.
    H-InvDB HIX0131234.
    HGNCi HGNC:19260. LTB4R2.
    HPAi CAB022689.
    HPA029680.
    MIMi 605773. gene.
    neXtProti NX_Q9NPC1.
    PharmGKBi PA134910672.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG308968.
    HOGENOMi HOG000008594.
    HOVERGENi HBG104134.
    InParanoidi Q9NPC1.
    KOi K04297.
    OMAi PRAGPRF.
    PhylomeDBi Q9NPC1.
    TreeFami TF330976.

    Enzyme and pathway databases

    Reactomei REACT_18283. G alpha (q) signalling events.
    REACT_18302. Leukotriene receptors.

    Miscellaneous databases

    GenomeRNAii 56413.
    NextBioi 61997.
    PROi Q9NPC1.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9NPC1.
    CleanExi HS_LTB4R2.
    Genevestigatori Q9NPC1.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR003981. Leukotriene_B4_rcpt.
    IPR003982. Leukotriene_B4_typ-2_rcpt.
    [Graphical view ]
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR01478. LTB2RECEPTOR.
    PR01476. LTBRECEPTOR.
    PROSITEi PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and characterization of cDNA encoding a novel human leukotriene B4 receptor."
      Tryselius Y., Nilsson N.E., Kotarsky K., Olde B., Owman C.
      Biochem. Biophys. Res. Commun. 274:377-382(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    2. "A second leukotriene B4 receptor, BLT2: a new therapeutic target in inflammation and immunological disorders."
      Yokomizo T., Kato K., Terawaki K., Izumi T., Shimizu T.
      J. Exp. Med. 192:421-432(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    3. "Probable G-protein coupled receptor."
      Hirose M., Urakawa I., Yamano S., Okazaki H.
      Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    4. "Identification and characterisation of a novel LTB4 receptor."
      Volpe F., Patel K., Barnes A., Sanseau P., Cousens D., Green A., Marshall F.
      Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    5. "cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
      Kopatz S.A., Aronstam R.S., Sharma S.V.
      Submitted (APR-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    6. "The DNA sequence and analysis of human chromosome 14."
      Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H.
      , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J.
      Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    8. "A novel hepatointestinal leukotriene B4 receptor: cloning and functional characterization."
      Wang S., Gustafson E., Pang L., Qiao X., Behan J., Maguire M., Bayne M., Laz T.
      J. Biol. Chem. 275:40686-40694(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 32-389 (ISOFORM 1).
    9. "Molecular cloning and characterization of another leukotriene B4 receptor."
      Kamohara M., Takasaki J., Matsumoto M., Saito T., Ohishi T., Ishii H., Furuichi K.
      J. Biol. Chem. 275:27000-27004(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 32-389 (ISOFORM 1).
    10. "Identification of G protein-coupled receptor genes from the human genome sequence."
      Takeda S., Kadowaki S., Haga T., Takaesu H., Mitaku S.
      FEBS Lett. 520:97-101(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] OF 32-389.

    Entry informationi

    Entry nameiLT4R2_HUMAN
    AccessioniPrimary (citable) accession number: Q9NPC1
    Secondary accession number(s): Q5KU28, Q9NPE5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 10, 2002
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 125 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 14
      Human chromosome 14: entries, gene names and cross-references to MIM
    3. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3