Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q9NPC1 (LT4R2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 120. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Leukotriene B4 receptor 2

Short name=LTB4-R 2
Short name=LTB4-R2
Alternative name(s):
LTB4 receptor JULF2
Leukotriene B4 receptor BLT2
Seven transmembrane receptor BLTR2
Gene names
Name:LTB4R2
Synonyms:BLT2R, BLTR2
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length389 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Low-affinity receptor for leukotrienes including leukotriene B4. Mediates chemotaxis of granulocytes and macrophages. The response is mediated via G-proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinities for the leukotrienes is LTB4 > 12-epi-LTB4 > LTB5 > LTB3.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Tissue specificity

Widely expressed.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Caution

It is uncertain whether Met-1 or Met-32 is the initiator.

Sequence caution

The sequence BAB00610.1 differs from that shown. Reason: Erroneous initiation.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q9NPC1-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q9NPC1-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-31: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 389389Leukotriene B4 receptor 2
PRO_0000069711

Regions

Topological domain1 – 5555Extracellular Potential
Transmembrane56 – 7621Helical; Name=1; Potential
Topological domain77 – 9115Cytoplasmic Potential
Transmembrane92 – 11221Helical; Name=2; Potential
Topological domain113 – 12715Extracellular Potential
Transmembrane128 – 14821Helical; Name=3; Potential
Topological domain149 – 17224Cytoplasmic Potential
Transmembrane173 – 19321Helical; Name=4; Potential
Topological domain194 – 21623Extracellular Potential
Transmembrane217 – 23721Helical; Name=5; Potential
Topological domain238 – 25619Cytoplasmic Potential
Transmembrane257 – 27721Helical; Name=6; Potential
Topological domain278 – 30629Extracellular Potential
Transmembrane307 – 32721Helical; Name=7; Potential
Topological domain328 – 38962Cytoplasmic Potential

Amino acid modifications

Glycosylation411N-linked (GlcNAc...) Potential

Natural variations

Alternative sequence1 – 3131Missing in isoform 2.
VSP_044885

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified October 1, 2000. Version 1.
Checksum: 8D6BC5A73A42F544

FASTA38941,525
        10         20         30         40         50         60 
MAPSHRASQV GFCPTPERPL WRLPPTCRPR RMSVCYRPPG NETLLSWKTS RATGTAFLLL 

        70         80         90        100        110        120 
AALLGLPGNG FVVWSLAGWR PARGRPLAAT LVLHLALADG AVLLLTPLFV AFLTRQAWPL 

       130        140        150        160        170        180 
GQAGCKAVYY VCALSMYASV LLTGLLSLQR CLAVTRPFLA PRLRSPALAR RLLLAVWLAA 

       190        200        210        220        230        240 
LLLAVPAAVY RHLWRDRVCQ LCHPSPVHAA AHLSLETLTA FVLPFGLMLG CYSVTLARLR 

       250        260        270        280        290        300 
GARWGSGRHG ARVGRLVSAI VLAFGLLWAP YHAVNLLQAV AALAPPEGAL AKLGGAGQAA 

       310        320        330        340        350        360 
RAGTTALAFF SSSVNPVLYV FTAGDLLPRA GPRFLTRLFE GSGEARGGGR SREGTMELRT 

       370        380 
TPQLKVVGQG RGNGDPGGGM EKDGPEWDL 

« Hide

Isoform 2 [UniParc].

Checksum: 5F5D98179CE00F3D
Show »

FASTA35837,942

References

« Hide 'large scale' references
[1]"Cloning and characterization of cDNA encoding a novel human leukotriene B4 receptor."
Tryselius Y., Nilsson N.E., Kotarsky K., Olde B., Owman C.
Biochem. Biophys. Res. Commun. 274:377-382(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[2]"A second leukotriene B4 receptor, BLT2: a new therapeutic target in inflammation and immunological disorders."
Yokomizo T., Kato K., Terawaki K., Izumi T., Shimizu T.
J. Exp. Med. 192:421-432(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[3]"Probable G-protein coupled receptor."
Hirose M., Urakawa I., Yamano S., Okazaki H.
Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
[4]"Identification and characterisation of a novel LTB4 receptor."
Volpe F., Patel K., Barnes A., Sanseau P., Cousens D., Green A., Marshall F.
Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[5]"cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
Kopatz S.A., Aronstam R.S., Sharma S.V.
Submitted (APR-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[6]"The DNA sequence and analysis of human chromosome 14."
Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H. expand/collapse author list , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J.
Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[8]"A novel hepatointestinal leukotriene B4 receptor: cloning and functional characterization."
Wang S., Gustafson E., Pang L., Qiao X., Behan J., Maguire M., Bayne M., Laz T.
J. Biol. Chem. 275:40686-40694(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 32-389 (ISOFORM 1).
[9]"Molecular cloning and characterization of another leukotriene B4 receptor."
Kamohara M., Takasaki J., Matsumoto M., Saito T., Ohishi T., Ishii H., Furuichi K.
J. Biol. Chem. 275:27000-27004(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 32-389 (ISOFORM 1).
[10]"Identification of G protein-coupled receptor genes from the human genome sequence."
Takeda S., Kadowaki S., Haga T., Takaesu H., Mitaku S.
FEBS Lett. 520:97-101(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] OF 32-389.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF277230 mRNA. Translation: AAF81261.1.
AB029892 mRNA. Translation: BAA99553.1.
AB008193 Genomic DNA. Translation: BAB00610.1. Different initiation.
AB032558 mRNA. Translation: BAD83590.1.
AJ278605 Genomic DNA. Translation: CAB96134.1.
AY268433 Genomic DNA. Translation: AAP23200.1.
AL096870 Genomic DNA. No translation available.
CH471078 Genomic DNA. Translation: EAW66030.1.
AF308571 mRNA. Translation: AAG40857.1.
AB044402 mRNA. Translation: BAA99539.1.
AB083604 Genomic DNA. Translation: BAB89317.1.
PIRJC7356.
RefSeqNP_001158164.1. NM_001164692.2.
NP_062813.2. NM_019839.4.
UniGeneHs.642693.
Hs.657595.

3D structure databases

ProteinModelPortalQ9NPC1.
SMRQ9NPC1. Positions 28-321.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid121143. 1 interaction.
IntActQ9NPC1. 1 interaction.
MINTMINT-8247212.
STRING9606.ENSP00000337731.

Chemistry

BindingDBQ9NPC1.
ChEMBLCHEMBL2095160.
GuidetoPHARMACOLOGY268.

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteQ9NPC1.

Polymorphism databases

DMDM23821812.

Proteomic databases

PaxDbQ9NPC1.
PRIDEQ9NPC1.

Protocols and materials databases

DNASU56413.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000533293; ENSP00000433290; ENSG00000213906. [Q9NPC1-2]
ENST00000543919; ENSP00000445772; ENSG00000213906. [Q9NPC1-2]
GeneID56413.
KEGGhsa:56413.
UCSCuc001wor.3. human. [Q9NPC1-1]

Organism-specific databases

CTD56413.
GeneCardsGC14P024778.
H-InvDBHIX0131234.
HGNCHGNC:19260. LTB4R2.
HPACAB022689.
HPA029680.
MIM605773. gene.
neXtProtNX_Q9NPC1.
PharmGKBPA134910672.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG308968.
HOGENOMHOG000008594.
HOVERGENHBG104134.
InParanoidQ9NPC1.
KOK04297.
OMAPRAGPRF.
PhylomeDBQ9NPC1.
TreeFamTF330976.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

BgeeQ9NPC1.
CleanExHS_LTB4R2.
GenevestigatorQ9NPC1.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR003981. Leukotriene_B4_rcpt.
IPR003982. Leukotriene_B4_typ-2_rcpt.
[Graphical view]
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PR01478. LTB2RECEPTOR.
PR01476. LTBRECEPTOR.
PROSITEPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi56413.
NextBio61997.
PROQ9NPC1.
SOURCESearch...

Entry information

Entry nameLT4R2_HUMAN
AccessionPrimary (citable) accession number: Q9NPC1
Secondary accession number(s): Q5KU28, Q9NPE5
Entry history
Integrated into UniProtKB/Swiss-Prot: October 10, 2002
Last sequence update: October 1, 2000
Last modified: April 16, 2014
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 14

Human chromosome 14: entries, gene names and cross-references to MIM

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries