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Q9NPC1

- LT4R2_HUMAN

UniProt

Q9NPC1 - LT4R2_HUMAN

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Protein

Leukotriene B4 receptor 2

Gene

LTB4R2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Low-affinity receptor for leukotrienes including leukotriene B4. Mediates chemotaxis of granulocytes and macrophages. The response is mediated via G-proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinities for the leukotrienes is LTB4 > 12-epi-LTB4 > LTB5 > LTB3.

GO - Molecular functioni

  1. leukotriene B4 receptor activity Source: Ensembl
  2. leukotriene receptor activity Source: ProtInc

GO - Biological processi

  1. chemotaxis Source: ProtInc
  2. keratinocyte migration Source: Ensembl
  3. negative regulation of adenylate cyclase activity Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiREACT_18283. G alpha (q) signalling events.
REACT_18302. Leukotriene receptors.

Names & Taxonomyi

Protein namesi
Recommended name:
Leukotriene B4 receptor 2
Short name:
LTB4-R 2
Short name:
LTB4-R2
Alternative name(s):
LTB4 receptor JULF2
Leukotriene B4 receptor BLT2
Seven transmembrane receptor BLTR2
Gene namesi
Name:LTB4R2
Synonyms:BLT2R, BLTR2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 14

Organism-specific databases

HGNCiHGNC:19260. LTB4R2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 5555ExtracellularSequence AnalysisAdd
BLAST
Transmembranei56 – 7621Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini77 – 9115CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei92 – 11221Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini113 – 12715ExtracellularSequence AnalysisAdd
BLAST
Transmembranei128 – 14821Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini149 – 17224CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei173 – 19321Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini194 – 21623ExtracellularSequence AnalysisAdd
BLAST
Transmembranei217 – 23721Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini238 – 25619CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei257 – 27721Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini278 – 30629ExtracellularSequence AnalysisAdd
BLAST
Transmembranei307 – 32721Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini328 – 38962CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of plasma membrane Source: ProtInc
  2. membrane Source: UniProtKB
  3. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134910672.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 389389Leukotriene B4 receptor 2PRO_0000069711Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi41 – 411N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9NPC1.
PRIDEiQ9NPC1.

PTM databases

PhosphoSiteiQ9NPC1.

Expressioni

Tissue specificityi

Widely expressed.

Gene expression databases

BgeeiQ9NPC1.
CleanExiHS_LTB4R2.
ExpressionAtlasiQ9NPC1. baseline.
GenevestigatoriQ9NPC1.

Organism-specific databases

HPAiCAB022689.
HPA029680.

Interactioni

Protein-protein interaction databases

BioGridi121143. 1 interaction.
IntActiQ9NPC1. 1 interaction.
MINTiMINT-8247212.
STRINGi9606.ENSP00000337731.

Structurei

3D structure databases

ProteinModelPortaliQ9NPC1.
SMRiQ9NPC1. Positions 28-321.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG308968.
GeneTreeiENSGT00760000118990.
HOGENOMiHOG000008594.
HOVERGENiHBG104134.
InParanoidiQ9NPC1.
KOiK04297.
OMAiPRAGPRF.
PhylomeDBiQ9NPC1.
TreeFamiTF330976.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR003981. Leukotriene_B4_rcpt.
IPR003982. Leukotriene_B4_typ-2_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01478. LTB2RECEPTOR.
PR01476. LTBRECEPTOR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9NPC1-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAPSHRASQV GFCPTPERPL WRLPPTCRPR RMSVCYRPPG NETLLSWKTS
60 70 80 90 100
RATGTAFLLL AALLGLPGNG FVVWSLAGWR PARGRPLAAT LVLHLALADG
110 120 130 140 150
AVLLLTPLFV AFLTRQAWPL GQAGCKAVYY VCALSMYASV LLTGLLSLQR
160 170 180 190 200
CLAVTRPFLA PRLRSPALAR RLLLAVWLAA LLLAVPAAVY RHLWRDRVCQ
210 220 230 240 250
LCHPSPVHAA AHLSLETLTA FVLPFGLMLG CYSVTLARLR GARWGSGRHG
260 270 280 290 300
ARVGRLVSAI VLAFGLLWAP YHAVNLLQAV AALAPPEGAL AKLGGAGQAA
310 320 330 340 350
RAGTTALAFF SSSVNPVLYV FTAGDLLPRA GPRFLTRLFE GSGEARGGGR
360 370 380
SREGTMELRT TPQLKVVGQG RGNGDPGGGM EKDGPEWDL
Length:389
Mass (Da):41,525
Last modified:October 1, 2000 - v1
Checksum:i8D6BC5A73A42F544
GO
Isoform 2 (identifier: Q9NPC1-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-31: Missing.

Note: No experimental confirmation available.

Show »
Length:358
Mass (Da):37,942
Checksum:i5F5D98179CE00F3D
GO

Sequence cautioni

The sequence BAB00610.1 differs from that shown. Reason: Erroneous initiation. Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 3131Missing in isoform 2. 1 PublicationVSP_044885Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF277230 mRNA. Translation: AAF81261.1.
AB029892 mRNA. Translation: BAA99553.1.
AB008193 Genomic DNA. Translation: BAB00610.1. Different initiation.
AB032558 mRNA. Translation: BAD83590.1.
AJ278605 Genomic DNA. Translation: CAB96134.1.
AY268433 Genomic DNA. Translation: AAP23200.1.
AL096870 Genomic DNA. No translation available.
CH471078 Genomic DNA. Translation: EAW66030.1.
AF308571 mRNA. Translation: AAG40857.1.
AB044402 mRNA. Translation: BAA99539.1.
AB083604 Genomic DNA. Translation: BAB89317.1.
CCDSiCCDS9625.2. [Q9NPC1-2]
PIRiJC7356.
RefSeqiNP_001158164.1. NM_001164692.2. [Q9NPC1-2]
NP_062813.2. NM_019839.4. [Q9NPC1-2]
UniGeneiHs.642693.
Hs.657595.

Genome annotation databases

EnsembliENST00000528054; ENSP00000432146; ENSG00000213906. [Q9NPC1-1]
ENST00000533293; ENSP00000433290; ENSG00000213906. [Q9NPC1-2]
ENST00000543919; ENSP00000445772; ENSG00000213906. [Q9NPC1-2]
GeneIDi56413.
KEGGihsa:56413.
UCSCiuc001wor.3. human. [Q9NPC1-1]

Polymorphism databases

DMDMi23821812.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF277230 mRNA. Translation: AAF81261.1 .
AB029892 mRNA. Translation: BAA99553.1 .
AB008193 Genomic DNA. Translation: BAB00610.1 . Different initiation.
AB032558 mRNA. Translation: BAD83590.1 .
AJ278605 Genomic DNA. Translation: CAB96134.1 .
AY268433 Genomic DNA. Translation: AAP23200.1 .
AL096870 Genomic DNA. No translation available.
CH471078 Genomic DNA. Translation: EAW66030.1 .
AF308571 mRNA. Translation: AAG40857.1 .
AB044402 mRNA. Translation: BAA99539.1 .
AB083604 Genomic DNA. Translation: BAB89317.1 .
CCDSi CCDS9625.2. [Q9NPC1-2 ]
PIRi JC7356.
RefSeqi NP_001158164.1. NM_001164692.2. [Q9NPC1-2 ]
NP_062813.2. NM_019839.4. [Q9NPC1-2 ]
UniGenei Hs.642693.
Hs.657595.

3D structure databases

ProteinModelPortali Q9NPC1.
SMRi Q9NPC1. Positions 28-321.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 121143. 1 interaction.
IntActi Q9NPC1. 1 interaction.
MINTi MINT-8247212.
STRINGi 9606.ENSP00000337731.

Chemistry

BindingDBi Q9NPC1.
ChEMBLi CHEMBL2095160.
GuidetoPHARMACOLOGYi 268.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei Q9NPC1.

Polymorphism databases

DMDMi 23821812.

Proteomic databases

PaxDbi Q9NPC1.
PRIDEi Q9NPC1.

Protocols and materials databases

DNASUi 56413.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000528054 ; ENSP00000432146 ; ENSG00000213906 . [Q9NPC1-1 ]
ENST00000533293 ; ENSP00000433290 ; ENSG00000213906 . [Q9NPC1-2 ]
ENST00000543919 ; ENSP00000445772 ; ENSG00000213906 . [Q9NPC1-2 ]
GeneIDi 56413.
KEGGi hsa:56413.
UCSCi uc001wor.3. human. [Q9NPC1-1 ]

Organism-specific databases

CTDi 56413.
GeneCardsi GC14P024778.
GC14P024789.
H-InvDB HIX0131234.
HGNCi HGNC:19260. LTB4R2.
HPAi CAB022689.
HPA029680.
MIMi 605773. gene.
neXtProti NX_Q9NPC1.
PharmGKBi PA134910672.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG308968.
GeneTreei ENSGT00760000118990.
HOGENOMi HOG000008594.
HOVERGENi HBG104134.
InParanoidi Q9NPC1.
KOi K04297.
OMAi PRAGPRF.
PhylomeDBi Q9NPC1.
TreeFami TF330976.

Enzyme and pathway databases

Reactomei REACT_18283. G alpha (q) signalling events.
REACT_18302. Leukotriene receptors.

Miscellaneous databases

GenomeRNAii 56413.
NextBioi 61997.
PROi Q9NPC1.
SOURCEi Search...

Gene expression databases

Bgeei Q9NPC1.
CleanExi HS_LTB4R2.
ExpressionAtlasi Q9NPC1. baseline.
Genevestigatori Q9NPC1.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR003981. Leukotriene_B4_rcpt.
IPR003982. Leukotriene_B4_typ-2_rcpt.
[Graphical view ]
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PR01478. LTB2RECEPTOR.
PR01476. LTBRECEPTOR.
PROSITEi PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and characterization of cDNA encoding a novel human leukotriene B4 receptor."
    Tryselius Y., Nilsson N.E., Kotarsky K., Olde B., Owman C.
    Biochem. Biophys. Res. Commun. 274:377-382(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "A second leukotriene B4 receptor, BLT2: a new therapeutic target in inflammation and immunological disorders."
    Yokomizo T., Kato K., Terawaki K., Izumi T., Shimizu T.
    J. Exp. Med. 192:421-432(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  3. "Probable G-protein coupled receptor."
    Hirose M., Urakawa I., Yamano S., Okazaki H.
    Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
  4. "Identification and characterisation of a novel LTB4 receptor."
    Volpe F., Patel K., Barnes A., Sanseau P., Cousens D., Green A., Marshall F.
    Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  5. "cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
    Kopatz S.A., Aronstam R.S., Sharma S.V.
    Submitted (APR-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  6. "The DNA sequence and analysis of human chromosome 14."
    Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H.
    , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J.
    Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  8. "A novel hepatointestinal leukotriene B4 receptor: cloning and functional characterization."
    Wang S., Gustafson E., Pang L., Qiao X., Behan J., Maguire M., Bayne M., Laz T.
    J. Biol. Chem. 275:40686-40694(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 32-389 (ISOFORM 1).
  9. "Molecular cloning and characterization of another leukotriene B4 receptor."
    Kamohara M., Takasaki J., Matsumoto M., Saito T., Ohishi T., Ishii H., Furuichi K.
    J. Biol. Chem. 275:27000-27004(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 32-389 (ISOFORM 1).
  10. "Identification of G protein-coupled receptor genes from the human genome sequence."
    Takeda S., Kadowaki S., Haga T., Takaesu H., Mitaku S.
    FEBS Lett. 520:97-101(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] OF 32-389.

Entry informationi

Entry nameiLT4R2_HUMAN
AccessioniPrimary (citable) accession number: Q9NPC1
Secondary accession number(s): Q5KU28, Q9NPE5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2002
Last sequence update: October 1, 2000
Last modified: November 26, 2014
This is version 127 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3