Q9NPB9 (CCRL1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
C-C chemokine receptor type 11
Short name=C-C CKR-11
Short name=CC-CKR-11
Short name=CCR-11

Alternative name(s):
CC chemokine receptor-like 1
Short name=CCRL1
CCX CKR

Gene names

Name:	CCRL1
Synonyms:	CCBP2, CCR11, VSHK1

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	350 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Receptor for CCL2, CCL8, CCL13, CCL19, CCL21 and CCL25. Ref.3
Subcellular location	Cell membrane; Multi-pass membrane protein.
Tissue specificity	Predominantly expressed in heart. Lower expression in lung, pancreas, spleen, colon, skeletal muscle and small intestine. Ref.1 Ref.2 Ref.7
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	chemotaxis Traceable author statement Ref.3. Source: ProtInc immune response Traceable author statement Ref.3. Source: ProtInc
Cellular_component	integral to plasma membrane Traceable author statement Ref.1. Source: ProtInc
Molecular_function	C-C chemokine receptor activity Inferred from electronic annotation. Source: InterPro chemokine receptor activity Traceable author statement Ref.3. Source: ProtInc
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 350	350	C-C chemokine receptor type 11		PRO_0000069296
Regions
	Topological domain	1 – 42	42	Extracellular Potential
	Transmembrane	43 – 63	21	Helical; Name=1; Potential
	Topological domain	64 – 87	24	Cytoplasmic Potential
	Transmembrane	88 – 108	21	Helical; Name=2; Potential
	Topological domain	109 – 113	5	Extracellular Potential
	Transmembrane	114 – 134	21	Helical; Name=3; Potential
	Topological domain	135 – 154	20	Cytoplasmic Potential
	Transmembrane	155 – 175	21	Helical; Name=4; Potential
	Topological domain	176 – 201	26	Extracellular Potential
	Transmembrane	202 – 222	21	Helical; Name=5; Potential
	Topological domain	223 – 240	18	Cytoplasmic Potential
	Transmembrane	241 – 261	21	Helical; Name=6; Potential
	Topological domain	262 – 289	28	Extracellular Potential
	Transmembrane	290 – 310	21	Helical; Name=7; Potential
	Topological domain	311 – 350	40	Cytoplasmic Potential
Amino acid modifications
	Glycosylation	6	1	N-linked (GlcNAc...) Potential
	Glycosylation	19	1	N-linked (GlcNAc...) Potential
	Disulfide bond	112 ↔ 184		By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9NPB9 [UniParc]. Last modified October 1, 2000. Version 1. Checksum: 8E26049D2D5757C8	FASTA	350	39,914
	10 20 30 40 50 60 MALEQNQSTD YYYEENEMNG TYDYSQYELI CIKEDVREFA KVFLPVFLTI VFVIGLAGNS 70 80 90 100 110 120 MVVAIYAYYK KQRTKTDVYI LNLAVADLLL LFTLPFWAVN AVHGWVLGKI MCKITSALYT 130 140 150 160 170 180 LNFVSGMQFL ACISIDRYVA VTKVPSQSGV GKPCWIICFC VWMAAILLSI PQLVFYTVND 190 200 210 220 230 240 NARCIPIFPR YLGTSMKALI QMLEICIGFV VPFLIMGVCY FITARTLMKM PNIKISRPLK 250 260 270 280 290 300 VLLTVVIVFI VTQLPYNIVK FCRAIDIIYS LITSCNMSKR MDIAIQVTES IALFHSCLNP 310 320 330 340 350 ILYVFMGASF KNYVMKVAKK YGSWRRQRQS VEEFPFDSEG PTEPTSTFSI

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning of CCRL1, an orphan seven transmembrane receptor related to chemokine receptors, expressed abundantly in the heart." Khoja H., Wang G., Ng C.-T.L., Tucker J., Brown T., Shyamala V. Gene 246:229-238(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
[2]	"CCR11 is a functional receptor for the monocyte chemoattractant protein family of chemokines." Schweickart V.L., Epp A., Raport C.J., Gray P.W. J. Biol. Chem. 275:9550-9556(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], TISSUE SPECIFICITY.
[3]	"Identification of a novel chemokine receptor that binds dendritic cell- and T cell-active chemokines including ELC, SLC, and TECK." Gosling J., Dairaghi D.J., Wang Y., Hanley M., Talbot D., Miao Z., Schall T.J. J. Immunol. 164:2851-2856(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION IN CHEMOKINES BINDING.
[4]	"cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)." Kopatz S.A., Aronstam R.S., Sharma S.V. Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[5]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[7]	"Characterization of mouse CCX-CKR, a receptor for the lymphocyte-attracting chemokines TECK/mCCL25, SLC/mCCL21 and MIP-3beta/mCCL19: comparison to human CCX-CKR." Townson J.R., Nibbs R.J. Eur. J. Immunol. 32:1230-1241(2002) [PubMed] [Europe PMC] [Abstract] Cited for: TISSUE SPECIFICITY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF110640 mRNA. Translation: AAF59827.1. AF193507 Genomic DNA. Translation: AAF61299.1. AF233281 Genomic DNA. Translation: AAF44751.1. AY221094 Genomic DNA. Translation: AAO65972.1. AK313923 mRNA. Translation: BAG36644.1. BC069438 mRNA. Translation: AAH69438.1.
IPI	IPI00014785.
RefSeq	NP_057641.1. NM_016557.2. NP_848540.1. NM_178445.1.
UniGene	Hs.310512. Hs.742565.
3D structure databases
ProteinModelPortal	Q9NPB9.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-5906N.
IntAct	Q9NPB9. 1 interaction.
STRING	9606.ENSP00000249887.
Protein family/group databases
GPCRDB	Search...
PTM databases
PhosphoSite	Q9NPB9.
Polymorphism databases
DMDM	14285406.
Proteomic databases
PaxDb	Q9NPB9.
PRIDE	Q9NPB9.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000249887; ENSP00000249887; ENSG00000129048.
GeneID	51554.
KEGG	hsa:51554.
UCSC	uc003eow.3. human.
Organism-specific databases
CTD	51554.
GeneCards	GC03P132316.
H-InvDB	HIX0094990.
HGNC	HGNC:1611. CCRL1.
MIM	606065. gene.
neXtProt	NX_Q9NPB9.
PharmGKB	PA35036.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG148788.
HOGENOM	HOG000234122.
HOVERGEN	HBG106917.
InParanoid	Q9NPB9.
KO	K04186.
OMA	LEICIGF.
OrthoDB	EOG48KRBK.
PhylomeDB	Q9NPB9.
Enzyme and pathway databases
Reactome	REACT_111102. Signal Transduction.
Gene expression databases
ArrayExpress	Q9NPB9.
Bgee	Q9NPB9.
CleanEx	HS_CCBP2. HS_CCRL1.
Genevestigator	Q9NPB9.
GermOnline	ENSG00000129048. Homo sapiens.
Family and domain databases
InterPro	IPR005383. Chemokine_CCR11. IPR000355. Chemokine_rcpt. IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM. [Graphical view]
Pfam	PF00001. 7tm_1. 1 hit. [Graphical view]
PRINTS	PR00657. CCCHEMOKINER. PR01558. CHEMOKINER11. PR00237. GPCRRHODOPSN.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
BindingDB	Q9NPB9.
ChEMBL	CHEMBL2917.
GenomeRNAi	51554.
NextBio	55338.
SOURCE	Search...

Entry information

Entry name

CCRL1_HUMAN

Accession

Primary (citable) accession number: Q9NPB9
Secondary accession number(s): B2R9U7

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 1, 2001
Last sequence update:	October 1, 2000
Last modified:	May 1, 2013
This is version 109 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.