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Q9NPB6

- PAR6A_HUMAN

UniProt

Q9NPB6 - PAR6A_HUMAN

Protein

Partitioning defective 6 homolog alpha

Gene

PARD6A

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 124 (01 Oct 2014)
      Sequence version 1 (01 Oct 2000)
      Previous versions | rss
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    Functioni

    Adapter protein involved in asymmetrical cell division and cell polarization processes. Probably involved in the formation of epithelial tight junctions. Association with PARD3 may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly. The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins.1 Publication

    GO - Molecular functioni

    1. GTP-dependent protein binding Source: UniProtKB
    2. protein binding Source: UniProtKB
    3. Rho GTPase binding Source: UniProtKB
    4. transcription factor binding Source: ProtInc

    GO - Biological processi

    1. cell-cell junction maintenance Source: UniProtKB
    2. cell-cell junction organization Source: Reactome
    3. cell cycle Source: UniProtKB-KW
    4. cell division Source: UniProtKB-KW
    5. cell junction assembly Source: Reactome
    6. tight junction assembly Source: Reactome
    7. transforming growth factor beta receptor signaling pathway Source: Reactome
    8. viral process Source: ProtInc

    Keywords - Biological processi

    Cell cycle, Cell division

    Enzyme and pathway databases

    ReactomeiREACT_120726. TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition).
    REACT_172638. Asymmetric localization of PCP proteins.
    REACT_19373. Tight junction interactions.
    SignaLinkiQ9NPB6.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Partitioning defective 6 homolog alpha
    Short name:
    PAR-6
    Short name:
    PAR-6 alpha
    Short name:
    PAR-6A
    Alternative name(s):
    PAR6C
    Tax interaction protein 40
    Short name:
    TIP-40
    Gene namesi
    Name:PARD6A
    Synonyms:PAR6A
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 16

    Organism-specific databases

    HGNCiHGNC:15943. PARD6A.

    Subcellular locationi

    Cytoplasm. Cell membrane. Cell projectionruffle. Cell junctiontight junction
    Note: Colocalizes with GTP-bound CDC42 or RAC1 at membrane ruffles and with PARD3 and PRKCI at epithelial tight junctions.

    GO - Cellular componenti

    1. apical part of cell Source: Ensembl
    2. cell cortex Source: Ensembl
    3. cytosol Source: Reactome
    4. nucleus Source: UniProtKB
    5. plasma membrane Source: Reactome
    6. protein complex Source: Ensembl
    7. ruffle Source: UniProtKB-SubCell
    8. tight junction Source: UniProtKB

    Keywords - Cellular componenti

    Cell junction, Cell membrane, Cell projection, Cytoplasm, Membrane, Tight junction

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi19 – 191K → A: Loss of interaction with ECT2 and PRKCI. 2 Publications
    Mutagenesisi28 – 281R → A: Slight decrease of interaction with PRKCI. Loss of interaction with PRKCI; when associated with A-89. 1 Publication
    Mutagenesisi89 – 891R → A: Slight decrease of interaction with PRKCI. Loss of interaction with PRKCI; when associated with A-28. 1 Publication

    Organism-specific databases

    PharmGKBiPA32937.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 346346Partitioning defective 6 homolog alphaPRO_0000112513Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei278 – 2781Phosphoserine2 Publications

    Post-translational modificationi

    Phosphorylated by the TGF-beta receptor.By similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PaxDbiQ9NPB6.
    PRIDEiQ9NPB6.

    PTM databases

    PhosphoSiteiQ9NPB6.

    Expressioni

    Tissue specificityi

    Expressed in pancreas, skeletal muscle, brain and heart. Weakly expressed in kidney and placenta.

    Gene expression databases

    BgeeiQ9NPB6.
    CleanExiHS_PARD6A.
    GenevestigatoriQ9NPB6.

    Organism-specific databases

    HPAiCAB009733.

    Interactioni

    Subunit structurei

    Interacts with MAP2K5 By similarity. Interacts with PARD3. Interacts with GTP-bound forms of CDC42, ARHQ/TC10 and RAC1. Interacts with the N-terminal part of PRKCI and PRKCZ. Part of a complex with PARD3, CDC42 or RAC1 and PRKCI or PRKCZ. Part of a complex with LLGL1 and PRKCI By similarity. Interacts with human T-cell leukemia virus type I TAX protein. Interacts with MPP5 and CRB3. Interacts with TGFBR1; involved in TGF-beta induced epithelial to mesenchymal transition. Interacts with ECT2 ('Thr-359' phosphorylated form) and PRKCI.By similarity12 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    CDC42P609537EBI-81876,EBI-81752
    CDH5P331514EBI-81876,EBI-2903122
    PARD3Q8TEW08EBI-81876,EBI-81968
    PNMA1Q8ND902EBI-81876,EBI-302345
    PRKCIP4174311EBI-81876,EBI-286199
    PRKCZQ055136EBI-81876,EBI-295351
    RAC1P630002EBI-81876,EBI-413628
    YWHAHQ049172EBI-81876,EBI-306940

    Protein-protein interaction databases

    BioGridi119157. 32 interactions.
    IntActiQ9NPB6. 20 interactions.
    MINTiMINT-191836.
    STRINGi9606.ENSP00000219255.

    Structurei

    Secondary structure

    1
    346
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi15 – 228
    Beta strandi25 – 328
    Helixi33 – 353
    Helixi39 – 4911
    Beta strandi58 – 625
    Beta strandi68 – 703
    Helixi74 – 807
    Beta strandi83 – 864
    Beta strandi88 – 936

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1WMHX-ray1.50B14-95[»]
    ProteinModelPortaliQ9NPB6.
    SMRiQ9NPB6. Positions 14-95, 126-252.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ9NPB6.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini15 – 9581OPRAdd
    BLAST
    Domaini133 – 15018Pseudo-CRIBAdd
    BLAST
    Domaini157 – 25094PDZPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 116116Interaction with PRKCI and PRKCZAdd
    BLAST
    Regioni126 – 253128Interaction with PARD3 and CDC42By similarityAdd
    BLAST

    Domaini

    The pseudo-CRIB domain together with the PDZ domain is required for the interaction with Rho small GTPases.By similarity
    The OPR domain mediates interactions with MAP2K5.By similarity
    The PDZ domain mediates the interaction with CRB3.1 Publication

    Sequence similaritiesi

    Belongs to the PAR6 family.Curated
    Contains 1 OPR domain.Curated
    Contains 1 PDZ (DHR) domain.PROSITE-ProRule annotation
    Contains 1 pseudo-CRIB domain.Curated

    Phylogenomic databases

    eggNOGiNOG315424.
    HOGENOMiHOG000231716.
    HOVERGENiHBG053509.
    InParanoidiQ9NPB6.
    KOiK06093.
    OMAiPCWDLHP.
    OrthoDBiEOG73JKWB.
    PhylomeDBiQ9NPB6.
    TreeFamiTF312899.

    Family and domain databases

    Gene3Di2.30.42.10. 1 hit.
    InterProiIPR000270. OPR_PB1.
    IPR001478. PDZ.
    [Graphical view]
    PfamiPF00564. PB1. 1 hit.
    PF00595. PDZ. 1 hit.
    [Graphical view]
    SMARTiSM00666. PB1. 1 hit.
    SM00228. PDZ. 1 hit.
    [Graphical view]
    SUPFAMiSSF50156. SSF50156. 1 hit.
    PROSITEiPS50106. PDZ. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9NPB6-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MARPQRTPAR SPDSIVEVKS KFDAEFRRFA LPRASVSGFQ EFSRLLRAVH    50
    QIPGLDVLLG YTDAHGDLLP LTNDDSLHRA LASGPPPLRL LVQKRAEADS 100
    SGLAFASNSL QRRKKGLLLR PVAPLRTRPP LLISLPQDFR QVSSVIDVDL 150
    LPETHRRVRL HKHGSDRPLG FYIRDGMSVR VAPQGLERVP GIFISRLVRG 200
    GLAESTGLLA VSDEILEVNG IEVAGKTLDQ VTDMMVANSH NLIVTVKPAN 250
    QRNNVVRGAS GRLTGPPSAG PGPAEPDSDD DSSDLVIENR QPPSSNGLSQ 300
    GPPCWDLHPG CRHPGTRSSL PSLDDQEQAS SGWGSRIRGD GSGFSL 346
    Length:346
    Mass (Da):37,388
    Last modified:October 1, 2000 - v1
    Checksum:i9241E0EDC3694AD4
    GO
    Isoform 2 (identifier: Q9NPB6-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         96-96: Missing.

    Show »
    Length:345
    Mass (Da):37,317
    Checksum:i035F9FA6BB62F085
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti286 – 2861V → I.
    Corresponds to variant rs35356834 [ dbSNP | Ensembl ].
    VAR_050454

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei96 – 961Missing in isoform 2. 4 PublicationsVSP_007459

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ277095 mRNA. Translation: CAB85490.1.
    AF265565 mRNA. Translation: AAF75548.1.
    AF252292 mRNA. Translation: AAF71529.1.
    AB043634 mRNA. Translation: BAA96235.1.
    AB041642 mRNA. Translation: BAB16105.1.
    BC015626 mRNA. Translation: AAH15626.1.
    AF028827 mRNA. Translation: AAB84252.1.
    CCDSiCCDS10843.1. [Q9NPB6-1]
    CCDS45514.1. [Q9NPB6-2]
    RefSeqiNP_001032358.1. NM_001037281.1. [Q9NPB6-2]
    NP_058644.1. NM_016948.2. [Q9NPB6-1]
    UniGeneiHs.112933.

    Genome annotation databases

    EnsembliENST00000219255; ENSP00000219255; ENSG00000102981. [Q9NPB6-1]
    ENST00000458121; ENSP00000392388; ENSG00000102981. [Q9NPB6-2]
    GeneIDi50855.
    KEGGihsa:50855.
    UCSCiuc002ets.3. human. [Q9NPB6-2]
    uc002ett.3. human. [Q9NPB6-1]

    Polymorphism databases

    DMDMi30913215.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ277095 mRNA. Translation: CAB85490.1 .
    AF265565 mRNA. Translation: AAF75548.1 .
    AF252292 mRNA. Translation: AAF71529.1 .
    AB043634 mRNA. Translation: BAA96235.1 .
    AB041642 mRNA. Translation: BAB16105.1 .
    BC015626 mRNA. Translation: AAH15626.1 .
    AF028827 mRNA. Translation: AAB84252.1 .
    CCDSi CCDS10843.1. [Q9NPB6-1 ]
    CCDS45514.1. [Q9NPB6-2 ]
    RefSeqi NP_001032358.1. NM_001037281.1. [Q9NPB6-2 ]
    NP_058644.1. NM_016948.2. [Q9NPB6-1 ]
    UniGenei Hs.112933.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1WMH X-ray 1.50 B 14-95 [» ]
    ProteinModelPortali Q9NPB6.
    SMRi Q9NPB6. Positions 14-95, 126-252.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 119157. 32 interactions.
    IntActi Q9NPB6. 20 interactions.
    MINTi MINT-191836.
    STRINGi 9606.ENSP00000219255.

    PTM databases

    PhosphoSitei Q9NPB6.

    Polymorphism databases

    DMDMi 30913215.

    Proteomic databases

    PaxDbi Q9NPB6.
    PRIDEi Q9NPB6.

    Protocols and materials databases

    DNASUi 50855.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000219255 ; ENSP00000219255 ; ENSG00000102981 . [Q9NPB6-1 ]
    ENST00000458121 ; ENSP00000392388 ; ENSG00000102981 . [Q9NPB6-2 ]
    GeneIDi 50855.
    KEGGi hsa:50855.
    UCSCi uc002ets.3. human. [Q9NPB6-2 ]
    uc002ett.3. human. [Q9NPB6-1 ]

    Organism-specific databases

    CTDi 50855.
    GeneCardsi GC16P067696.
    HGNCi HGNC:15943. PARD6A.
    HPAi CAB009733.
    MIMi 607484. gene.
    neXtProti NX_Q9NPB6.
    PharmGKBi PA32937.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG315424.
    HOGENOMi HOG000231716.
    HOVERGENi HBG053509.
    InParanoidi Q9NPB6.
    KOi K06093.
    OMAi PCWDLHP.
    OrthoDBi EOG73JKWB.
    PhylomeDBi Q9NPB6.
    TreeFami TF312899.

    Enzyme and pathway databases

    Reactomei REACT_120726. TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition).
    REACT_172638. Asymmetric localization of PCP proteins.
    REACT_19373. Tight junction interactions.
    SignaLinki Q9NPB6.

    Miscellaneous databases

    ChiTaRSi PARD6A. human.
    EvolutionaryTracei Q9NPB6.
    GeneWikii PARD6A.
    GenomeRNAii 50855.
    NextBioi 53337.
    PROi Q9NPB6.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9NPB6.
    CleanExi HS_PARD6A.
    Genevestigatori Q9NPB6.

    Family and domain databases

    Gene3Di 2.30.42.10. 1 hit.
    InterProi IPR000270. OPR_PB1.
    IPR001478. PDZ.
    [Graphical view ]
    Pfami PF00564. PB1. 1 hit.
    PF00595. PDZ. 1 hit.
    [Graphical view ]
    SMARTi SM00666. PB1. 1 hit.
    SM00228. PDZ. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50156. SSF50156. 1 hit.
    PROSITEi PS50106. PDZ. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The mammalian homologue of the Caenorhabditis elegans polarity protein PAR-6 is a binding partner for the Rho GTPases Cdc42 and Rac1."
      Johansson A.-S., Driessens M., Aspenstroem P.
      J. Cell Sci. 113:3267-3275(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), CHARACTERIZATION, INTERACTION WITH PARD3; CDC42 AND RAC1.
      Tissue: B-cell.
    2. "A human homolog of the Caenorhabditis elegans polarity determinant Par-6 links Rac and Cdc42 to PKC-zeta signaling and cell transformation."
      Qiu R.-G., Abo A., Martin G.S.
      Curr. Biol. 10:697-707(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), FUNCTION, INTERACTION WITH CDC42; RAC1 AND PRKCZ.
      Tissue: Cervix carcinoma.
    3. "The cell-polarity protein Par6 links Par3 and atypical protein kinase C to Cdc42."
      Joberty G., Petersen C., Gao L., Macara I.G.
      Nat. Cell Biol. 2:531-539(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), INTERACTION WITH ARHQ.
      Tissue: Brain.
    4. "Atypical protein kinase C is involved in the evolutionarily conserved par protein complex and plays a critical role in establishing epithelia-specific junctional structures."
      Suzuki A., Yamanaka T., Hirose T., Manabe N., Mizuno K., Shimizu M., Akimoto K., Izumi Y., Ohnishi T., Ohno S.
      J. Cell Biol. 152:1183-1196(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), SUBUNIT OF A COMPLEX CONTAINING PARD3 AND PRKCI.
      Tissue: Kidney.
    5. "Human homologues of the Caenorhabditis elegans cell polarity protein PAR6 as an adaptor that links the small GTPases Rac and Cdc42 to atypical protein kinase C."
      Noda Y., Takeya R., Ohno S., Naito S., Ito T., Sumimoto H.
      Genes Cells 6:107-119(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), INTERACTION WITH RAC1; CDC42; PRKCI AND PRKCZ.
      Tissue: Neuroblastoma.
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Eye.
    7. "The C-terminus of the HTLV-1 Tax oncoprotein mediates interaction with the PDZ domain of cellular proteins."
      Rousset R., Fabre S., Desbois C., Bantignies F., Jalinot P.
      Oncogene 16:643-654(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 115-345, INTERACTION WITH HTLV-1 TAX.
      Tissue: Lymphocyte.
    8. "Direct interaction of two polarity complexes implicated in epithelial tight junction assembly."
      Hurd T.W., Gao L., Roh M.H., Macara I.G., Margolis B.
      Nat. Cell Biol. 5:137-142(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH MPP5.
    9. "CRB3 binds directly to Par6 and regulates the morphogenesis of the tight junctions in mammalian epithelial cells."
      Lemmers C., Michel D., Lane-Guermonprez L., Delgrossi M.-H., Medina E., Arsanto J.-P., Le Bivic A.
      Mol. Biol. Cell 15:1324-1333(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH CRB3, DOMAIN.
    10. "Nucleotide exchange factor ECT2 interacts with the polarity protein complex Par6/Par3/protein kinase Czeta (PKCzeta) and regulates PKCzeta activity."
      Liu X.F., Ishida H., Raziuddin R., Miki T.
      Mol. Cell. Biol. 24:6665-6675(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH ECT2.
    11. "Regulation of the polarity protein Par6 by TGFbeta receptors controls epithelial cell plasticity."
      Ozdamar B., Bose R., Barrios-Rodiles M., Wang H.R., Zhang Y., Wrana J.L.
      Science 307:1603-1609(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH TGFBR1, PHOSPHORYLATION BY TGF-BETA RECEPTOR.
    12. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
      Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
      Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-278, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    13. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    14. "Ect2 links the PKCiota-Par6alpha complex to Rac1 activation and cellular transformation."
      Justilien V., Fields A.P.
      Oncogene 28:3597-3607(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH ECT2 AND PRKCI, MUTAGENESIS OF LYS-19.
    15. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    16. "Structure of a cell polarity regulator, a complex between atypical PKC and Par6 PB1 domains."
      Hirano Y., Yoshinaga S., Takeya R., Suzuki N.N., Horiuchi M., Kohjima M., Sumimoto H., Inagaki F.
      J. Biol. Chem. 280:9653-9661(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.5 ANGSTROMS) OF 14-95 IN COMPLEX WITH PRKCI, MUTAGENESIS OF LYS-19; ARG-28 AND ARG-89.

    Entry informationi

    Entry nameiPAR6A_HUMAN
    AccessioniPrimary (citable) accession number: Q9NPB6
    Secondary accession number(s): O14911, Q9NPJ7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 16, 2003
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 124 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 16
      Human chromosome 16: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3