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Q9NPB6

- PAR6A_HUMAN

UniProt

Q9NPB6 - PAR6A_HUMAN

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Protein

Partitioning defective 6 homolog alpha

Gene

PARD6A

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Adapter protein involved in asymmetrical cell division and cell polarization processes. Probably involved in the formation of epithelial tight junctions. Association with PARD3 may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly. The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins.1 Publication

GO - Molecular functioni

  1. GTP-dependent protein binding Source: UniProtKB
  2. Rho GTPase binding Source: UniProtKB
  3. transcription factor binding Source: ProtInc

GO - Biological processi

  1. cell-cell junction maintenance Source: UniProtKB
  2. cell-cell junction organization Source: Reactome
  3. cell cycle Source: UniProtKB-KW
  4. cell division Source: UniProtKB-KW
  5. cell junction assembly Source: Reactome
  6. tight junction assembly Source: Reactome
  7. transforming growth factor beta receptor signaling pathway Source: Reactome
  8. viral process Source: ProtInc
Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division

Enzyme and pathway databases

ReactomeiREACT_120726. TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition).
REACT_172638. Asymmetric localization of PCP proteins.
REACT_19373. Tight junction interactions.
SignaLinkiQ9NPB6.

Names & Taxonomyi

Protein namesi
Recommended name:
Partitioning defective 6 homolog alpha
Short name:
PAR-6
Short name:
PAR-6 alpha
Short name:
PAR-6A
Alternative name(s):
PAR6C
Tax interaction protein 40
Short name:
TIP-40
Gene namesi
Name:PARD6A
Synonyms:PAR6A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 16

Organism-specific databases

HGNCiHGNC:15943. PARD6A.

Subcellular locationi

Cytoplasm. Cell membrane. Cell projectionruffle. Cell junctiontight junction
Note: Colocalizes with GTP-bound CDC42 or RAC1 at membrane ruffles and with PARD3 and PRKCI at epithelial tight junctions.

GO - Cellular componenti

  1. apical part of cell Source: Ensembl
  2. cell cortex Source: Ensembl
  3. cell projection Source: UniProtKB-KW
  4. cytosol Source: Reactome
  5. nucleus Source: UniProtKB
  6. plasma membrane Source: Reactome
  7. protein complex Source: Ensembl
  8. tight junction Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Cell projection, Cytoplasm, Membrane, Tight junction

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi19 – 191K → A: Loss of interaction with ECT2 and PRKCI. 2 Publications
Mutagenesisi28 – 281R → A: Slight decrease of interaction with PRKCI. Loss of interaction with PRKCI; when associated with A-89. 1 Publication
Mutagenesisi89 – 891R → A: Slight decrease of interaction with PRKCI. Loss of interaction with PRKCI; when associated with A-28. 1 Publication

Organism-specific databases

PharmGKBiPA32937.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 346346Partitioning defective 6 homolog alphaPRO_0000112513Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei278 – 2781Phosphoserine1 Publication

Post-translational modificationi

Phosphorylated by the TGF-beta receptor.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9NPB6.
PaxDbiQ9NPB6.
PRIDEiQ9NPB6.

PTM databases

PhosphoSiteiQ9NPB6.

Expressioni

Tissue specificityi

Expressed in pancreas, skeletal muscle, brain and heart. Weakly expressed in kidney and placenta.

Gene expression databases

BgeeiQ9NPB6.
CleanExiHS_PARD6A.
ExpressionAtlasiQ9NPB6. baseline and differential.
GenevestigatoriQ9NPB6.

Organism-specific databases

HPAiCAB009733.

Interactioni

Subunit structurei

Interacts with MAP2K5 (By similarity). Interacts with PARD3. Interacts with GTP-bound forms of CDC42, ARHQ/TC10 and RAC1. Interacts with the N-terminal part of PRKCI and PRKCZ. Part of a complex with PARD3, CDC42 or RAC1 and PRKCI or PRKCZ. Part of a complex with LLGL1 and PRKCI (By similarity). Interacts with human T-cell leukemia virus type I TAX protein. Interacts with MPP5 and CRB3. Interacts with TGFBR1; involved in TGF-beta induced epithelial to mesenchymal transition. Interacts with ECT2 ('Thr-359' phosphorylated form) and PRKCI.By similarity12 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
CDC42P609537EBI-81876,EBI-81752
CDH5P331514EBI-81876,EBI-2903122
PARD3Q8TEW08EBI-81876,EBI-81968
PNMA1Q8ND902EBI-81876,EBI-302345
PRKCIP4174311EBI-81876,EBI-286199
PRKCZQ055136EBI-81876,EBI-295351
RAC1P630002EBI-81876,EBI-413628
YWHAHQ049172EBI-81876,EBI-306940

Protein-protein interaction databases

BioGridi119157. 33 interactions.
IntActiQ9NPB6. 20 interactions.
MINTiMINT-191836.
STRINGi9606.ENSP00000219255.

Structurei

Secondary structure

1
346
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi15 – 228Combined sources
Beta strandi25 – 328Combined sources
Helixi33 – 353Combined sources
Helixi39 – 4911Combined sources
Beta strandi58 – 625Combined sources
Beta strandi68 – 703Combined sources
Helixi74 – 807Combined sources
Beta strandi83 – 864Combined sources
Beta strandi88 – 936Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1WMHX-ray1.50B14-95[»]
ProteinModelPortaliQ9NPB6.
SMRiQ9NPB6. Positions 14-95, 126-252.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9NPB6.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini15 – 9581OPRAdd
BLAST
Domaini133 – 15018Pseudo-CRIBAdd
BLAST
Domaini157 – 25094PDZPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 116116Interaction with PRKCI and PRKCZAdd
BLAST
Regioni126 – 253128Interaction with PARD3 and CDC42By similarityAdd
BLAST

Domaini

The pseudo-CRIB domain together with the PDZ domain is required for the interaction with Rho small GTPases.By similarity
The OPR domain mediates interactions with MAP2K5.By similarity
The PDZ domain mediates the interaction with CRB3.1 Publication

Sequence similaritiesi

Belongs to the PAR6 family.Curated
Contains 1 OPR domain.Curated
Contains 1 PDZ (DHR) domain.PROSITE-ProRule annotation
Contains 1 pseudo-CRIB domain.Curated

Phylogenomic databases

eggNOGiNOG315424.
GeneTreeiENSGT00390000005255.
HOGENOMiHOG000231716.
HOVERGENiHBG053509.
InParanoidiQ9NPB6.
KOiK06093.
OMAiPCWDLHP.
OrthoDBiEOG73JKWB.
PhylomeDBiQ9NPB6.
TreeFamiTF312899.

Family and domain databases

Gene3Di2.30.42.10. 1 hit.
InterProiIPR000270. OPR_PB1.
IPR001478. PDZ.
[Graphical view]
PfamiPF00564. PB1. 1 hit.
PF00595. PDZ. 1 hit.
[Graphical view]
SMARTiSM00666. PB1. 1 hit.
SM00228. PDZ. 1 hit.
[Graphical view]
SUPFAMiSSF50156. SSF50156. 1 hit.
PROSITEiPS50106. PDZ. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9NPB6-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MARPQRTPAR SPDSIVEVKS KFDAEFRRFA LPRASVSGFQ EFSRLLRAVH
60 70 80 90 100
QIPGLDVLLG YTDAHGDLLP LTNDDSLHRA LASGPPPLRL LVQKRAEADS
110 120 130 140 150
SGLAFASNSL QRRKKGLLLR PVAPLRTRPP LLISLPQDFR QVSSVIDVDL
160 170 180 190 200
LPETHRRVRL HKHGSDRPLG FYIRDGMSVR VAPQGLERVP GIFISRLVRG
210 220 230 240 250
GLAESTGLLA VSDEILEVNG IEVAGKTLDQ VTDMMVANSH NLIVTVKPAN
260 270 280 290 300
QRNNVVRGAS GRLTGPPSAG PGPAEPDSDD DSSDLVIENR QPPSSNGLSQ
310 320 330 340
GPPCWDLHPG CRHPGTRSSL PSLDDQEQAS SGWGSRIRGD GSGFSL
Length:346
Mass (Da):37,388
Last modified:October 1, 2000 - v1
Checksum:i9241E0EDC3694AD4
GO
Isoform 2 (identifier: Q9NPB6-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     96-96: Missing.

Show »
Length:345
Mass (Da):37,317
Checksum:i035F9FA6BB62F085
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti286 – 2861V → I.
Corresponds to variant rs35356834 [ dbSNP | Ensembl ].
VAR_050454

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei96 – 961Missing in isoform 2. 4 PublicationsVSP_007459

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ277095 mRNA. Translation: CAB85490.1.
AF265565 mRNA. Translation: AAF75548.1.
AF252292 mRNA. Translation: AAF71529.1.
AB043634 mRNA. Translation: BAA96235.1.
AB041642 mRNA. Translation: BAB16105.1.
BC015626 mRNA. Translation: AAH15626.1.
AF028827 mRNA. Translation: AAB84252.1.
CCDSiCCDS10843.1. [Q9NPB6-1]
CCDS45514.1. [Q9NPB6-2]
RefSeqiNP_001032358.1. NM_001037281.1. [Q9NPB6-2]
NP_058644.1. NM_016948.2. [Q9NPB6-1]
UniGeneiHs.112933.

Genome annotation databases

EnsembliENST00000219255; ENSP00000219255; ENSG00000102981. [Q9NPB6-1]
ENST00000458121; ENSP00000392388; ENSG00000102981. [Q9NPB6-2]
GeneIDi50855.
KEGGihsa:50855.
UCSCiuc002ets.3. human. [Q9NPB6-2]
uc002ett.3. human. [Q9NPB6-1]

Polymorphism databases

DMDMi30913215.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ277095 mRNA. Translation: CAB85490.1 .
AF265565 mRNA. Translation: AAF75548.1 .
AF252292 mRNA. Translation: AAF71529.1 .
AB043634 mRNA. Translation: BAA96235.1 .
AB041642 mRNA. Translation: BAB16105.1 .
BC015626 mRNA. Translation: AAH15626.1 .
AF028827 mRNA. Translation: AAB84252.1 .
CCDSi CCDS10843.1. [Q9NPB6-1 ]
CCDS45514.1. [Q9NPB6-2 ]
RefSeqi NP_001032358.1. NM_001037281.1. [Q9NPB6-2 ]
NP_058644.1. NM_016948.2. [Q9NPB6-1 ]
UniGenei Hs.112933.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1WMH X-ray 1.50 B 14-95 [» ]
ProteinModelPortali Q9NPB6.
SMRi Q9NPB6. Positions 14-95, 126-252.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 119157. 33 interactions.
IntActi Q9NPB6. 20 interactions.
MINTi MINT-191836.
STRINGi 9606.ENSP00000219255.

PTM databases

PhosphoSitei Q9NPB6.

Polymorphism databases

DMDMi 30913215.

Proteomic databases

MaxQBi Q9NPB6.
PaxDbi Q9NPB6.
PRIDEi Q9NPB6.

Protocols and materials databases

DNASUi 50855.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000219255 ; ENSP00000219255 ; ENSG00000102981 . [Q9NPB6-1 ]
ENST00000458121 ; ENSP00000392388 ; ENSG00000102981 . [Q9NPB6-2 ]
GeneIDi 50855.
KEGGi hsa:50855.
UCSCi uc002ets.3. human. [Q9NPB6-2 ]
uc002ett.3. human. [Q9NPB6-1 ]

Organism-specific databases

CTDi 50855.
GeneCardsi GC16P067696.
HGNCi HGNC:15943. PARD6A.
HPAi CAB009733.
MIMi 607484. gene.
neXtProti NX_Q9NPB6.
PharmGKBi PA32937.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG315424.
GeneTreei ENSGT00390000005255.
HOGENOMi HOG000231716.
HOVERGENi HBG053509.
InParanoidi Q9NPB6.
KOi K06093.
OMAi PCWDLHP.
OrthoDBi EOG73JKWB.
PhylomeDBi Q9NPB6.
TreeFami TF312899.

Enzyme and pathway databases

Reactomei REACT_120726. TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition).
REACT_172638. Asymmetric localization of PCP proteins.
REACT_19373. Tight junction interactions.
SignaLinki Q9NPB6.

Miscellaneous databases

ChiTaRSi PARD6A. human.
EvolutionaryTracei Q9NPB6.
GeneWikii PARD6A.
GenomeRNAii 50855.
NextBioi 53337.
PROi Q9NPB6.
SOURCEi Search...

Gene expression databases

Bgeei Q9NPB6.
CleanExi HS_PARD6A.
ExpressionAtlasi Q9NPB6. baseline and differential.
Genevestigatori Q9NPB6.

Family and domain databases

Gene3Di 2.30.42.10. 1 hit.
InterProi IPR000270. OPR_PB1.
IPR001478. PDZ.
[Graphical view ]
Pfami PF00564. PB1. 1 hit.
PF00595. PDZ. 1 hit.
[Graphical view ]
SMARTi SM00666. PB1. 1 hit.
SM00228. PDZ. 1 hit.
[Graphical view ]
SUPFAMi SSF50156. SSF50156. 1 hit.
PROSITEi PS50106. PDZ. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The mammalian homologue of the Caenorhabditis elegans polarity protein PAR-6 is a binding partner for the Rho GTPases Cdc42 and Rac1."
    Johansson A.-S., Driessens M., Aspenstroem P.
    J. Cell Sci. 113:3267-3275(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), CHARACTERIZATION, INTERACTION WITH PARD3; CDC42 AND RAC1.
    Tissue: B-cell.
  2. "A human homolog of the Caenorhabditis elegans polarity determinant Par-6 links Rac and Cdc42 to PKC-zeta signaling and cell transformation."
    Qiu R.-G., Abo A., Martin G.S.
    Curr. Biol. 10:697-707(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), FUNCTION, INTERACTION WITH CDC42; RAC1 AND PRKCZ.
    Tissue: Cervix carcinoma.
  3. "The cell-polarity protein Par6 links Par3 and atypical protein kinase C to Cdc42."
    Joberty G., Petersen C., Gao L., Macara I.G.
    Nat. Cell Biol. 2:531-539(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), INTERACTION WITH ARHQ.
    Tissue: Brain.
  4. "Atypical protein kinase C is involved in the evolutionarily conserved par protein complex and plays a critical role in establishing epithelia-specific junctional structures."
    Suzuki A., Yamanaka T., Hirose T., Manabe N., Mizuno K., Shimizu M., Akimoto K., Izumi Y., Ohnishi T., Ohno S.
    J. Cell Biol. 152:1183-1196(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), SUBUNIT OF A COMPLEX CONTAINING PARD3 AND PRKCI.
    Tissue: Kidney.
  5. "Human homologues of the Caenorhabditis elegans cell polarity protein PAR6 as an adaptor that links the small GTPases Rac and Cdc42 to atypical protein kinase C."
    Noda Y., Takeya R., Ohno S., Naito S., Ito T., Sumimoto H.
    Genes Cells 6:107-119(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), INTERACTION WITH RAC1; CDC42; PRKCI AND PRKCZ.
    Tissue: Neuroblastoma.
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Eye.
  7. "The C-terminus of the HTLV-1 Tax oncoprotein mediates interaction with the PDZ domain of cellular proteins."
    Rousset R., Fabre S., Desbois C., Bantignies F., Jalinot P.
    Oncogene 16:643-654(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 115-345, INTERACTION WITH HTLV-1 TAX.
    Tissue: Lymphocyte.
  8. "Direct interaction of two polarity complexes implicated in epithelial tight junction assembly."
    Hurd T.W., Gao L., Roh M.H., Macara I.G., Margolis B.
    Nat. Cell Biol. 5:137-142(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH MPP5.
  9. "CRB3 binds directly to Par6 and regulates the morphogenesis of the tight junctions in mammalian epithelial cells."
    Lemmers C., Michel D., Lane-Guermonprez L., Delgrossi M.-H., Medina E., Arsanto J.-P., Le Bivic A.
    Mol. Biol. Cell 15:1324-1333(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH CRB3, DOMAIN.
  10. "Nucleotide exchange factor ECT2 interacts with the polarity protein complex Par6/Par3/protein kinase Czeta (PKCzeta) and regulates PKCzeta activity."
    Liu X.F., Ishida H., Raziuddin R., Miki T.
    Mol. Cell. Biol. 24:6665-6675(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH ECT2.
  11. "Regulation of the polarity protein Par6 by TGFbeta receptors controls epithelial cell plasticity."
    Ozdamar B., Bose R., Barrios-Rodiles M., Wang H.R., Zhang Y., Wrana J.L.
    Science 307:1603-1609(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH TGFBR1, PHOSPHORYLATION BY TGF-BETA RECEPTOR.
  12. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
    Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
    Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-278, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  13. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  14. "Ect2 links the PKCiota-Par6alpha complex to Rac1 activation and cellular transformation."
    Justilien V., Fields A.P.
    Oncogene 28:3597-3607(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH ECT2 AND PRKCI, MUTAGENESIS OF LYS-19.
  15. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  16. "Structure of a cell polarity regulator, a complex between atypical PKC and Par6 PB1 domains."
    Hirano Y., Yoshinaga S., Takeya R., Suzuki N.N., Horiuchi M., Kohjima M., Sumimoto H., Inagaki F.
    J. Biol. Chem. 280:9653-9661(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.5 ANGSTROMS) OF 14-95 IN COMPLEX WITH PRKCI, MUTAGENESIS OF LYS-19; ARG-28 AND ARG-89.

Entry informationi

Entry nameiPAR6A_HUMAN
AccessioniPrimary (citable) accession number: Q9NPB6
Secondary accession number(s): O14911, Q9NPJ7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 16, 2003
Last sequence update: October 1, 2000
Last modified: November 26, 2014
This is version 126 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3