Q9NPB3 (CABP2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Calcium-binding protein 2
Short name=CaBP2

Gene names

Name:

CABP2

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	220 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Subcellular location	Cytoplasm › perinuclear region. Cell membrane; Lipid-anchor; Cytoplasmic side. Golgi apparatus Ref.4.
Tissue specificity	Retina. Ref.3
Sequence similarities	Contains 4 EF-hand domains.

Ontologies

Keywords
Cellular component	Cell membrane Cytoplasm Golgi apparatus Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Repeat
Ligand	Calcium
PTM	Lipoprotein Myristate
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	signal transduction Traceable author statement. Source: ProtInc
Cellular component	Golgi apparatus Inferred from electronic annotation. Source: UniProtKB-SubCell perinuclear region of cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	calcium ion binding Traceable author statement. Source: ProtInc
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform L-CaBP2 (identifier: Q9NPB3-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform S-CaBP2 (identifier: Q9NPB3-2)

The sequence of this isoform differs from the canonical sequence as follows:
     15-71: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed
	Chain	2 – 220	219	Calcium-binding protein 2		PRO_0000073517
Regions
	Domain	78 – 113	36	EF-hand 1
	Domain	111 – 146	36	EF-hand 2
	Domain	152 – 187	36	EF-hand 3
	Domain	189 – 220	32	EF-hand 4
	Calcium binding	91 – 102	12	1 Potential
	Calcium binding	165 – 176	12	2 Potential
	Calcium binding	202 – 213	12	3 Potential
Amino acid modifications
	Lipidation	2	1	N-myristoyl glycine Ref.1
Natural variations
	Alternative sequence	15 – 71	57	Missing in isoform S-CaBP2.		VSP_000734
	Natural variant	94	1	R → Q. Ref.1 Corresponds to variant rs2276118 [ dbSNP | Ensembl ].		VAR_063087

Sequences

	Sequence		Length	Mass (Da)
	Isoform L-CaBP2 [UniParc]. Last modified April 20, 2010. Version 4. Checksum: 9A0F0E7358A44F3A	FASTA	220	24,482
	10 20 30 40 50 60 MGNCAKRPWR RGPKDPLQWL GSPPRGSCPS PSSSPKEQGD PAPGVQGYSV LNSLVGPACI 70 80 90 100 110 120 FLRPSIAATQ LDRELRPEEI EELQVAFQEF DRDRDGYIGC RELGACMRTL GYMPTEMELI 130 140 150 160 170 180 EISQQISGGK VDFEDFVELM GPKLLAETAD MIGVRELRDA FREFDTNGDG RISVGELRAA 190 200 210 220 LKALLGERLS QREVDEILQD VDLNGDGLVD FEEFVRMMSR
	Isoform S-CaBP2 [UniParc]. Checksum: 8A69C8BA13039349	FASTA	163	18,667
	10 20 30 40 50 60 MGNCAKRPWR RGPKDRELRP EEIEELQVAF QEFDRDRDGY IGCRELGACM RTLGYMPTEM 70 80 90 100 110 120 ELIEISQQIS GGKVDFEDFV ELMGPKLLAE TADMIGVREL RDAFREFDTN GDGRISVGEL 130 140 150 160 RAALKALLGE RLSQREVDEI LQDVDLNGDG LVDFEEFVRM MSR

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Five members of a novel Ca(2+)-binding protein (CABP) subfamily with similarity to calmodulin." Haeseleer F., Sokal I., Verlinde C.L.M.J., Erdjument-Bromage H., Tempst P., Pronin A.N., Benovic J.L., Fariss R.N., Palczewski K. J. Biol. Chem. 275:1247-1260(2000) [PubMed: 10625670] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORMS L-CABP2 AND S-CABP2), VARIANT GLN-94, MYRISTOYLATION AT GLY-2. Tissue: Retina.
[2]	"Human chromosome 11 DNA sequence and analysis including novel gene identification." Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K., Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T., Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G. , Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C., Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A., Hattori M., Rogers J., Lander E.S., Sakaki Y. Nature 440:497-500(2006) [PubMed: 16554811] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"Ca(2+)-binding proteins in the retina: from discovery to etiology of human disease." Sokal I., Li N., Verlinde C.L.M.J., Haeseleer F., Baehr W., Palczewski K. Biochim. Biophys. Acta 1498:233-251(2000) [PubMed: 11108966] [Abstract] Cited for: TISSUE SPECIFICITY.
[4]	"Membrane targeting of the EF-hand containing calcium-sensing proteins CaBP7 and CaBP8." McCue H.V., Burgoyne R.D., Haynes L.P. Biochem. Biophys. Res. Commun. 380:825-831(2009) [PubMed: 19338761] [Abstract] Cited for: SUBCELLULAR LOCATION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF170811 Genomic DNA. Translation: AAF26283.1. AF169154 mRNA. Translation: AAF25788.1. AP001184 Genomic DNA. No translation available.
IPI	IPI00009916. IPI00220015.
RefSeq	NP_057450.2. NM_016366.2.
UniGene	Hs.278984.
3D structure databases
ProteinModelPortal	Q9NPB3.
SMR	Q9NPB3. Positions 71-220.
ModBase	Search...
Protein-protein interaction databases
STRING	Q9NPB3.
Polymorphism databases
DMDM	294862530.
Proteomic databases
PRIDE	Q9NPB3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000294288; ENSP00000294288; ENSG00000167791.
GeneID	51475.
KEGG	hsa:51475.
UCSC	uc001omc.1. human. uc001omd.1. human.
Organism-specific databases
CTD	51475.
GeneCards	GC11M067286.
H-InvDB	HIX0201705.
HGNC	HGNC:1385. CABP2.
MIM	607314. gene.
neXtProt	NX_Q9NPB3.
PharmGKB	PA26001.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG12675.
GeneTree	ENSGT00590000082834.
HOGENOM	HBG746798.
HOVERGEN	HBG012180.
InParanoid	Q9NPB3.
OMA	CAKRPRH.
OrthoDB	EOG44BB3F.
PhylomeDB	Q9NPB3.
Gene expression databases
ArrayExpress	Q9NPB3.
Bgee	Q9NPB3.
CleanEx	HS_CABP2.
Genevestigator	Q9NPB3.
GermOnline	ENSG00000167791. Homo sapiens.
Family and domain databases
InterPro	IPR015754. Ca_binding_pro. IPR018248. EF-hand. IPR011992. EF-hand-like_dom. IPR018247. EF_Hand_1_Ca_BS. IPR018249. EF_HAND_2. IPR002048. EF_hand_Ca-bd. [Graphical view]
Gene3D	G3DSA:1.10.238.10. EF-Hand_type. 2 hits.
PANTHER	PTHR23050:SF21. Ca_binding_pro. 1 hit.
Pfam	PF00036. efhand. 3 hits. [Graphical view]
SMART	SM00054. EFh. 3 hits. [Graphical view]
PROSITE	PS00018. EF_HAND_1. 3 hits. PS50222. EF_HAND_2. 4 hits. [Graphical view]
ProtoNet	Search...
Other
NextBio	55113.
SOURCE	Search...

Entry information

Entry name

CABP2_HUMAN

Accession

Primary (citable) accession number: Q9NPB3

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 27, 2001
Last sequence update:	April 20, 2010
Last modified:	January 25, 2012
This is version 88 of the entry and version 4 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.