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Protein

SAYSvFN domain-containing protein 1

Gene

SAYSD1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
SAYSvFN domain-containing protein 1
Gene namesi
Name:SAYSD1
Synonyms:C6orf64
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 6

Organism-specific databases

HGNCiHGNC:21025. SAYSD1.

Subcellular locationi

Cytoplasmic vesicle membrane 1 Publication; Single-pass membrane protein 1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei106 – 12621HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. cytoplasmic vesicle membrane Source: UniProtKB-SubCell
  2. integral component of membrane Source: UniProtKB-KW
  3. intracellular membrane-bounded organelle Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasmic vesicle, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA128394689.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 183183SAYSvFN domain-containing protein 1PRO_0000089517Add
BLAST

Proteomic databases

MaxQBiQ9NPB0.
PaxDbiQ9NPB0.
PRIDEiQ9NPB0.

PTM databases

PhosphoSiteiQ9NPB0.

Expressioni

Gene expression databases

BgeeiQ9NPB0.
CleanExiHS_C6orf64.
ExpressionAtlasiQ9NPB0. baseline and differential.
GenevestigatoriQ9NPB0.

Organism-specific databases

HPAiHPA007959.

Interactioni

Protein-protein interaction databases

BioGridi120891. 1 interaction.
IntActiQ9NPB0. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ9NPB0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi6 – 4439Ala-richAdd
BLAST

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG248608.
GeneTreeiENSGT00390000004313.
HOGENOMiHOG000044257.
HOVERGENiHBG081100.
InParanoidiQ9NPB0.
OMAiFLVWKPR.
OrthoDBiEOG7JX36V.
PhylomeDBiQ9NPB0.
TreeFamiTF106140.

Family and domain databases

InterProiIPR019387. Uncharacterised_SAYSvFN.
[Graphical view]
PfamiPF10260. SAYSvFN. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9NPB0-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEQRLAEFRA ARKRAGLAAQ PPAASQGAQT PGEKAEAAAT LKAAPGWLKR
60 70 80 90 100
FLVWKPRPAS ARAQPGLVQE AAQPQGSTSE TPWNTAIPLP SCWDQSFLTN
110 120 130 140 150
ITFLKVLLWL VLLGLFVELE FGLAYFVLSL FYWMYVGTRG PEEKKEGEKS
160 170 180
AYSVFNPGCE AIQGTLTAEQ LERELQLRPL AGR
Length:183
Mass (Da):20,163
Last modified:October 1, 2000 - v1
Checksum:i9C0B2CAB5F638A46
GO
Isoform 2 (identifier: Q9NPB0-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-67: Missing.
     68-69: VQ → ML

Note: No experimental confirmation available.

Show »
Length:116
Mass (Da):13,092
Checksum:i5E8379D37A27244C
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 6767Missing in isoform 2. 1 PublicationVSP_014597Add
BLAST
Alternative sequencei68 – 692VQ → ML in isoform 2. 1 PublicationVSP_014598

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL136839 mRNA. Translation: CAB66773.1.
AK001963 mRNA. Translation: BAA92004.1.
AL035690 Genomic DNA. Translation: CAB71176.1.
AL035690 Genomic DNA. Translation: CAD92546.1.
BC022007 mRNA. Translation: AAH22007.1.
CCDSiCCDS4840.1. [Q9NPB0-1]
RefSeqiNP_060792.1. NM_018322.1. [Q9NPB0-1]
XP_005249279.1. XM_005249222.1. [Q9NPB0-2]
UniGeneiHs.58382.

Genome annotation databases

EnsembliENST00000229903; ENSP00000229903; ENSG00000112167. [Q9NPB0-1]
ENST00000373249; ENSP00000362346; ENSG00000112167. [Q9NPB0-2]
GeneIDi55776.
KEGGihsa:55776.
UCSCiuc003ook.1. human. [Q9NPB0-1]

Polymorphism databases

DMDMi68565322.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL136839 mRNA. Translation: CAB66773.1.
AK001963 mRNA. Translation: BAA92004.1.
AL035690 Genomic DNA. Translation: CAB71176.1.
AL035690 Genomic DNA. Translation: CAD92546.1.
BC022007 mRNA. Translation: AAH22007.1.
CCDSiCCDS4840.1. [Q9NPB0-1]
RefSeqiNP_060792.1. NM_018322.1. [Q9NPB0-1]
XP_005249279.1. XM_005249222.1. [Q9NPB0-2]
UniGeneiHs.58382.

3D structure databases

ProteinModelPortaliQ9NPB0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120891. 1 interaction.
IntActiQ9NPB0. 1 interaction.

PTM databases

PhosphoSiteiQ9NPB0.

Polymorphism databases

DMDMi68565322.

Proteomic databases

MaxQBiQ9NPB0.
PaxDbiQ9NPB0.
PRIDEiQ9NPB0.

Protocols and materials databases

DNASUi55776.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000229903; ENSP00000229903; ENSG00000112167. [Q9NPB0-1]
ENST00000373249; ENSP00000362346; ENSG00000112167. [Q9NPB0-2]
GeneIDi55776.
KEGGihsa:55776.
UCSCiuc003ook.1. human. [Q9NPB0-1]

Organism-specific databases

CTDi55776.
GeneCardsiGC06M039259.
HGNCiHGNC:21025. SAYSD1.
HPAiHPA007959.
neXtProtiNX_Q9NPB0.
PharmGKBiPA128394689.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG248608.
GeneTreeiENSGT00390000004313.
HOGENOMiHOG000044257.
HOVERGENiHBG081100.
InParanoidiQ9NPB0.
OMAiFLVWKPR.
OrthoDBiEOG7JX36V.
PhylomeDBiQ9NPB0.
TreeFamiTF106140.

Miscellaneous databases

ChiTaRSiSAYSD1. human.
GenomeRNAii55776.
NextBioi60847.
PROiQ9NPB0.

Gene expression databases

BgeeiQ9NPB0.
CleanExiHS_C6orf64.
ExpressionAtlasiQ9NPB0. baseline and differential.
GenevestigatoriQ9NPB0.

Family and domain databases

InterProiIPR019387. Uncharacterised_SAYSvFN.
[Graphical view]
PfamiPF10260. SAYSvFN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Testis.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Placenta.
  3. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Testis.
  5. "Systematic validation of antibody binding and protein subcellular localization using siRNA and confocal microscopy."
    Stadler C., Hjelmare M., Neumann B., Jonasson K., Pepperkok R., Uhlen M., Lundberg E.
    J. Proteomics 75:2236-2251(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.

Entry informationi

Entry nameiSMDC1_HUMAN
AccessioniPrimary (citable) accession number: Q9NPB0
Secondary accession number(s): Q9H0D8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: October 1, 2000
Last modified: January 7, 2015
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.