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Protein

SAYSvFN domain-containing protein 1

Gene

SAYSD1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
SAYSvFN domain-containing protein 1
Gene namesi
Name:SAYSD1
Synonyms:C6orf64
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000112167.9
HGNCiHGNC:21025 SAYSD1
neXtProtiNX_Q9NPB0

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei106 – 126HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Cytoplasmic vesicle, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000112167
PharmGKBiPA128394689

Polymorphism and mutation databases

BioMutaiSAYSD1
DMDMi68565322

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000895171 – 183SAYSvFN domain-containing protein 1Add BLAST183

Proteomic databases

EPDiQ9NPB0
MaxQBiQ9NPB0
PaxDbiQ9NPB0
PeptideAtlasiQ9NPB0
PRIDEiQ9NPB0
ProteomicsDBi81954
81955 [Q9NPB0-2]

PTM databases

iPTMnetiQ9NPB0
PhosphoSitePlusiQ9NPB0

Expressioni

Gene expression databases

BgeeiENSG00000112167
CleanExiHS_C6orf64
GenevisibleiQ9NPB0 HS

Organism-specific databases

HPAiHPA007959

Interactioni

Protein-protein interaction databases

BioGridi120891, 14 interactors
IntActiQ9NPB0, 3 interactors
MINTiQ9NPB0
STRINGi9606.ENSP00000229903

Structurei

3D structure databases

ProteinModelPortaliQ9NPB0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi6 – 44Ala-richAdd BLAST39

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3249 Eukaryota
ENOG41127HA LUCA
GeneTreeiENSGT00390000004313
HOGENOMiHOG000044257
HOVERGENiHBG081100
InParanoidiQ9NPB0
OMAiFLVWKPR
OrthoDBiEOG091G0YM2
PhylomeDBiQ9NPB0
TreeFamiTF106140

Family and domain databases

InterProiView protein in InterPro
IPR019387 Uncharacterised_SAYSvFN
PfamiView protein in Pfam
PF10260 SAYSvFN, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9NPB0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEQRLAEFRA ARKRAGLAAQ PPAASQGAQT PGEKAEAAAT LKAAPGWLKR
60 70 80 90 100
FLVWKPRPAS ARAQPGLVQE AAQPQGSTSE TPWNTAIPLP SCWDQSFLTN
110 120 130 140 150
ITFLKVLLWL VLLGLFVELE FGLAYFVLSL FYWMYVGTRG PEEKKEGEKS
160 170 180
AYSVFNPGCE AIQGTLTAEQ LERELQLRPL AGR
Length:183
Mass (Da):20,163
Last modified:October 1, 2000 - v1
Checksum:i9C0B2CAB5F638A46
GO
Isoform 2 (identifier: Q9NPB0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-67: Missing.
     68-69: VQ → ML

Note: No experimental confirmation available.
Show »
Length:116
Mass (Da):13,092
Checksum:i5E8379D37A27244C
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0145971 – 67Missing in isoform 2. 1 PublicationAdd BLAST67
Alternative sequenceiVSP_01459868 – 69VQ → ML in isoform 2. 1 Publication2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL136839 mRNA Translation: CAB66773.1
AK001963 mRNA Translation: BAA92004.1
AL035690 Genomic DNA No translation available.
BC022007 mRNA Translation: AAH22007.1
CCDSiCCDS4840.1 [Q9NPB0-1]
CCDS78135.1 [Q9NPB0-2]
RefSeqiNP_001291722.1, NM_001304793.1 [Q9NPB0-2]
NP_060792.1, NM_018322.2 [Q9NPB0-1]
UniGeneiHs.58382

Genome annotation databases

EnsembliENST00000229903; ENSP00000229903; ENSG00000112167 [Q9NPB0-1]
ENST00000373249; ENSP00000362346; ENSG00000112167 [Q9NPB0-2]
GeneIDi55776
KEGGihsa:55776
UCSCiuc003ook.2 human [Q9NPB0-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiSMDC1_HUMAN
AccessioniPrimary (citable) accession number: Q9NPB0
Secondary accession number(s): Q9H0D8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: October 1, 2000
Last modified: June 20, 2018
This is version 124 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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