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Protein

Transcription and mRNA export factor ENY2

Gene

ENY2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in mRNA export coupled transcription activation by association with both the TREX-2 and the SAGA complexes. The transcription regulatory histone acetylation (HAT) complex SAGA is a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates in a subcomplex that specifically deubiquitinates both histones H2A and H2B. The SAGA complex is recruited to specific gene promoters by activators such as MYC, where it is required for transcription. Required for nuclear receptor-mediated transactivation. The TREX-2 complex functions in docking export-competent ribonucleoprotein particles (mRNPs) to the nuclear entrance of the nuclear pore complex (nuclear basket). TREX-2 participates in mRNA export and accurate chromatin positioning in the nucleus by tethering genes to the nuclear periphery.2 Publications

GO - Molecular functioni

  • chromatin binding Source: GO_Central
  • ligand-dependent nuclear receptor transcription coactivator activity Source: UniProtKB
  • transcription coactivator activity Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionActivator, Chromatin regulator
Biological processmRNA transport, Protein transport, Transcription, Transcription regulation, Translocation, Transport

Enzyme and pathway databases

ReactomeiR-HSA-3214847 HATs acetylate histones

Protein family/group databases

TCDBi1.I.1.1.3 the eukaryotic nuclear pore complex (e-npc) family

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription and mRNA export factor ENY2UniRule annotation
Alternative name(s):
Enhancer of yellow 2 transcription factor homologUniRule annotation
Gene namesi
Name:ENY2UniRule annotation
ORF Names:DC6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

EuPathDBiHostDB:ENSG00000120533.12
HGNCiHGNC:24449 ENY2
neXtProtiNX_Q9NPA8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nuclear pore complex, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi56943
OpenTargetsiENSG00000120533
PharmGKBiPA142671907

Polymorphism and mutation databases

BioMutaiENY2
DMDMi74752879

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003141301 – 101Transcription and mRNA export factor ENY2Add BLAST101

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki74Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Isoform 2 (identifier: Q9NPA8-2)
Modified residuei1N-acetylmethionineCombined sources1

Keywords - PTMi

Acetylation, Isopeptide bond, Ubl conjugation

Proteomic databases

EPDiQ9NPA8
MaxQBiQ9NPA8
PaxDbiQ9NPA8
PeptideAtlasiQ9NPA8
PRIDEiQ9NPA8
TopDownProteomicsiQ9NPA8-1 [Q9NPA8-1]

PTM databases

iPTMnetiQ9NPA8
PhosphoSitePlusiQ9NPA8

Expressioni

Gene expression databases

BgeeiENSG00000120533
CleanExiHS_ENY2
ExpressionAtlasiQ9NPA8 baseline and differential
GenevisibleiQ9NPA8 HS

Organism-specific databases

HPAiHPA024648

Interactioni

Subunit structurei

Component of the nuclear pore complex (NPC)-associated TREX-2 complex (transcription and export complex 2), composed of at least ENY2, GANP, PCID2, SEM1, and either centrin CETN2 or CETN3. TREX-2 contains 2 ENY2 chains. The TREX-2 complex interacts with the nucleoporin NUP153 (PubMed:22307388). Component of some SAGA transcription coactivator-HAT complexes, at least composed of ATXN7, ATXN7L3, ENY2, GCN5L2, SUPT3H, TAF10, TRRAP and USP22. Within the SAGA complex, ENY2, ATXN7, ATXN7L3, and USP22 form an additional subcomplex of SAGA called the DUB module (deubiquitination module) (PubMed:18206972, PubMed:21746879, PubMed:27601583). Interacts directly with ATXN7L3, GANP and with the RNA polymerase II (PubMed:22307388). Interacts strongly with ATXN7L3 and ATXN7L3B (PubMed:27601583).UniRule annotation4 Publications

Protein-protein interaction databases

BioGridi121267, 20 interactors
CORUMiQ9NPA8
IntActiQ9NPA8, 17 interactors
MINTiQ9NPA8
STRINGi9606.ENSP00000429986

Structurei

Secondary structure

1101
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi10 – 22Combined sources13
Helixi25 – 39Combined sources15
Helixi42 – 57Combined sources16
Turni59 – 61Combined sources3
Helixi64 – 78Combined sources15
Helixi81 – 98Combined sources18

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4DHXX-ray2.10B/C/E/F1-101[»]
ProteinModelPortaliQ9NPA8
SMRiQ9NPA8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ENY2 family.UniRule annotation

Phylogenomic databases

eggNOGiKOG4479 Eukaryota
ENOG4111PHC LUCA
GeneTreeiENSGT00390000011748
HOVERGENiHBG107852
InParanoidiQ9NPA8
KOiK11368
OMAiAHCKDVI
OrthoDBiEOG091G11OD
PhylomeDBiQ9NPA8
TreeFamiTF326556

Family and domain databases

Gene3Di1.10.246.140, 1 hit
HAMAPiMF_03046 ENY2_Sus1, 1 hit
InterProiView protein in InterPro
IPR018783 TF_ENY2
IPR038212 TF_EnY2_sf
PANTHERiPTHR12514 PTHR12514, 1 hit
PfamiView protein in Pfam
PF10163 EnY2, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9NPA8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVVSKMNKDA QMRAAINQKL IETGERERLK ELLRAKLIEC GWKDQLKAHC
60 70 80 90 100
KEVIKEKGLE HVTVDDLVAE ITPKGRALVP DSVKKELLQR IRTFLAQHAS

L
Length:101
Mass (Da):11,529
Last modified:October 1, 2000 - v1
Checksum:iA0617024C59AABFB
GO
Isoform 2 (identifier: Q9NPA8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-5: Missing.

Note: Gene prediction based on EST data.Combined sources
Show »
Length:96
Mass (Da):10,984
Checksum:i5A6C33C154264A47
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0468911 – 5Missing in isoform 2. Curated5

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF173296 mRNA Translation: AAF89829.1
AF201940 mRNA Translation: AAF86876.1
AK290752 mRNA Translation: BAF83441.1
AK316560 mRNA Translation: BAG38149.1
CR457183 mRNA Translation: CAG33464.1
AC021237 Genomic DNA No translation available.
CH471060 Genomic DNA Translation: EAW91927.1
CH471060 Genomic DNA Translation: EAW91930.1
BC007870 mRNA Translation: AAH07870.1
CCDSiCCDS43762.1 [Q9NPA8-1]
CCDS55270.1 [Q9NPA8-2]
RefSeqiNP_001180486.1, NM_001193557.1 [Q9NPA8-2]
NP_064574.1, NM_020189.5 [Q9NPA8-1]
UniGeneiHs.492555

Genome annotation databases

EnsembliENST00000521662; ENSP00000429713; ENSG00000120533 [Q9NPA8-2]
ENST00000521688; ENSP00000429986; ENSG00000120533 [Q9NPA8-1]
GeneIDi56943
KEGGihsa:56943
UCSCiuc003ync.4 human [Q9NPA8-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiENY2_HUMAN
AccessioniPrimary (citable) accession number: Q9NPA8
Secondary accession number(s): B2RE52, G3V117
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: October 1, 2000
Last modified: May 23, 2018
This is version 127 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

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