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Q9NPA5 (ZF64A_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 122. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Zinc finger protein 64 homolog, isoforms 1 and 2

Short name=Zfp-64
Alternative name(s):
Zinc finger protein 338
Gene names
Name:ZFP64
Synonyms:ZNF338
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length681 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May be involved in transcriptional regulation.

Subcellular location

Nucleus Probable.

Sequence similarities

Belongs to the krueppel C2H2-type zinc-finger protein family.

Contains 9 C2H2-type zinc fingers.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Cellular componentNucleus
   Coding sequence diversityAlternative splicing
Polymorphism
   DomainRepeat
Zinc-finger
   LigandDNA-binding
Metal-binding
Zinc
   Technical term3D-structure
Complete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processregulation of transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentnucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionDNA binding

Inferred from electronic annotation. Source: UniProtKB-KW

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Alternative products

This entry describes 5 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q9NPA5-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q9NPA5-2)

The sequence of this isoform differs from the canonical sequence as follows:
     96-149: Missing.
Isoform 3 (identifier: Q9NTW7-1)

The sequence of this isoform can be found in the external entry Q9NTW7.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Isoform 4 (identifier: Q9NTW7-2)

Also known as: ZNF338;

The sequence of this isoform can be found in the external entry Q9NTW7.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Isoform 5 (identifier: Q9NTW7-3)

The sequence of this isoform can be found in the external entry Q9NTW7.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 681681Zinc finger protein 64 homolog, isoforms 1 and 2
PRO_0000047307

Regions

Zinc finger175 – 19723C2H2-type 1
Zinc finger203 – 22523C2H2-type 2
Zinc finger231 – 25323C2H2-type 3
Zinc finger259 – 28123C2H2-type 4
Zinc finger287 – 31024C2H2-type 5
Zinc finger315 – 33723C2H2-type 6
Zinc finger343 – 36523C2H2-type 7
Zinc finger371 – 39424C2H2-type 8
Zinc finger425 – 44723C2H2-type 9

Sites

Metal binding3451Zinc 1
Metal binding3481Zinc 1
Metal binding3611Zinc 1
Metal binding3651Zinc 1
Metal binding3731Zinc 2
Metal binding3761Zinc 2
Metal binding3891Zinc 2
Metal binding3941Zinc 2

Natural variations

Alternative sequence96 – 14954Missing in isoform 2.
VSP_007284
Natural variant681Q → P.
Corresponds to variant rs7353222 [ dbSNP | Ensembl ].
VAR_028019
Natural variant1391P → L.
Corresponds to variant rs6021773 [ dbSNP | Ensembl ].
VAR_028020
Natural variant4251F → Y.
Corresponds to variant rs16996517 [ dbSNP | Ensembl ].
VAR_028021
Natural variant4511S → N. Ref.1 Ref.3
Corresponds to variant rs3746414 [ dbSNP | Ensembl ].
VAR_028022

Secondary structure

.................................. 681
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified October 17, 2006. Version 3.
Checksum: 949C2DB54BB97E2E

FASTA68174,644
        10         20         30         40         50         60 
MNASSEGESF AGSVQIPGGT TVLVELTPDI HICGICKQQF NNLDAFVAHK QSGCQLTGTS 

        70         80         90        100        110        120 
AAAPSTVQFV SEETVPATQT QTTTRTITSE TQTITVSAPE FVFEHGYQTY LPTESNENQT 

       130        140        150        160        170        180 
ATVISLPAKS RTKKPTTPPA QKRLNCCYPG CQFKTAYGMK DMERHLKIHT GDKPHKCEVC 

       190        200        210        220        230        240 
GKCFSRKDKL KTHMRCHTGV KPYKCKTCDY AAADSSSLNK HLRIHSDERP FKCQICPYAS 

       250        260        270        280        290        300 
RNSSQLTVHL RSHTGDAPFQ CWLCSAKFKI SSDLKRHMRV HSGEKPFKCE FCNVRCTMKG 

       310        320        330        340        350        360 
NLKSHIRIKH SGNNFKCPHC DFLGDSKATL RKHSRVHQSE HPEKCSECSY SCSSKAALRI 

       370        380        390        400        410        420 
HERIHCTDRP FKCNYCSFDT KQPSNLSKHM KKFHGDMVKT EALERKDTGR QSSRQVAKLD 

       430        440        450        460        470        480 
AKKSFHCDIC DASFMREDSL RSHKRQHSEY SESKNSDVTV LQFQIDPSKQ PATPLTVGHL 

       490        500        510        520        530        540 
QVPLQPSQVP QFSEGRVKII VGHQVPQANT IVQAAAAAVN IVPPALVAQN PEELPGNSRL 

       550        560        570        580        590        600 
QILRQVSLIA PPQSSRCPSE AGAMTQPAVL LTTHEQTDGA TLHQTLIPTA SGGPQEGSGN 

       610        620        630        640        650        660 
QTFITSSGIT CTDFEGLNAL IQEGTAEVTV VSDGGQNIAV ATTAPPVFSS SSQQELPKQT 

       670        680 
YSIIQGAAHP ALLCPADSIP D 

« Hide

Isoform 2 [UniParc].

Checksum: A4EE9B17845C00EF
Show »

FASTA62768,621
Isoform 3 [UniParc].

See Q9NTW7.

Isoform 4 (ZNF338) [UniParc].

See Q9NTW7.

Isoform 5 [UniParc].

See Q9NTW7.

References

« Hide 'large scale' references
[1]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANT ASN-451.
Tissue: Neuron.
[2]"The DNA sequence and comparative analysis of human chromosome 20."
Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E. expand/collapse author list , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ASN-451.
Tissue: Lymph.
[4]"Solution structure of the C2H2 type zinc-binding domain of human zinc finger protein 64, isoforms 1 and 2."
RIKEN structural genomics initiative (RSGI)
Submitted (MAY-2005) to the PDB data bank
Cited for: STRUCTURE BY NMR OF 339-397, ZINC-BINDING SITES.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK001596 mRNA. Translation: BAA91777.1.
AK001744 mRNA. Translation: BAA91876.1.
AL121771 Genomic DNA. Translation: CAB90276.1.
AL121771 Genomic DNA. Translation: CAB90277.1.
BC012759 mRNA. Translation: AAH12759.1.
BC041622 mRNA. Translation: AAH41622.1.
RefSeqNP_060667.2. NM_018197.2.
NP_071371.3. NM_022088.4.
NP_955458.1. NM_199426.1.
NP_955459.2. NM_199427.2.
UniGeneHs.473082.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1X5WNMR-A341-397[»]
2DMDNMR-A174-256[»]
ProteinModelPortalQ9NPA5.
SMRQ9NPA5. Positions 30-447.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid120853. 13 interactions.
IntActQ9NPA5. 4 interactions.
STRING9606.ENSP00000216923.

PTM databases

PhosphoSiteQ9NPA5.

Polymorphism databases

DMDM116242854.

Proteomic databases

PaxDbQ9NPA5.
PRIDEQ9NPA5.

Protocols and materials databases

DNASU55734.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000216923; ENSP00000216923; ENSG00000020256. [Q9NPA5-1]
ENST00000346617; ENSP00000344615; ENSG00000020256. [Q9NPA5-2]
GeneID55734.
KEGGhsa:55734.
UCSCuc002xwl.3. human. [Q9NPA5-1]
uc002xwn.3. human. [Q9NPA5-2]

Organism-specific databases

CTD55734.
GeneCardsGC20M050668.
HGNCHGNC:15940. ZFP64.
HPAHPA035112.
neXtProtNX_Q9NPA5.
PharmGKBPA38060.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG5048.
HOGENOMHOG000230887.
HOVERGENHBG056373.
InParanoidQ9NPA5.
OrthoDBEOG7XM2XF.
PhylomeDBQ9NPA5.
TreeFamTF333046.

Gene expression databases

ArrayExpressQ9NPA5.
BgeeQ9NPA5.
CleanExHS_ZFP64.
GenevestigatorQ9NPA5.

Family and domain databases

Gene3D3.30.160.60. 9 hits.
InterProIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
SMARTSM00355. ZnF_C2H2. 11 hits.
[Graphical view]
PROSITEPS00028. ZINC_FINGER_C2H2_1. 5 hits.
PS50157. ZINC_FINGER_C2H2_2. 9 hits.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceQ9NPA5.
GeneWikiZFP64.
GenomeRNAi55734.
NextBio60666.

Entry information

Entry nameZF64A_HUMAN
AccessionPrimary (citable) accession number: Q9NPA5
Secondary accession number(s): Q9NTS7, Q9NVH4
Entry history
Integrated into UniProtKB/Swiss-Prot: April 30, 2003
Last sequence update: October 17, 2006
Last modified: March 19, 2014
This is version 122 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 20

Human chromosome 20: entries, gene names and cross-references to MIM