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Protein

Zinc finger protein 64 homolog, isoforms 1 and 2

Gene

ZFP64

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi345 – 3451Zinc 1
Metal bindingi348 – 3481Zinc 1
Metal bindingi361 – 3611Zinc 1
Metal bindingi365 – 3651Zinc 1
Metal bindingi373 – 3731Zinc 2
Metal bindingi376 – 3761Zinc 2
Metal bindingi389 – 3891Zinc 2
Metal bindingi394 – 3941Zinc 2

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri175 – 19723C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri203 – 22523C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri231 – 25323C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri259 – 28123C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri287 – 31024C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri315 – 33723C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri343 – 36523C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri371 – 39424C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri425 – 44723C2H2-type 9PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 64 homolog, isoforms 1 and 2
Short name:
Zfp-64
Alternative name(s):
Zinc finger protein 338
Gene namesi
Name:ZFP64
Synonyms:ZNF338
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 20

Organism-specific databases

HGNCiHGNC:15940. ZFP64.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA38060.

Polymorphism and mutation databases

BioMutaiSALL4.
DMDMi116242854.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 681681Zinc finger protein 64 homolog, isoforms 1 and 2PRO_0000047307Add
BLAST

Proteomic databases

MaxQBiQ9NPA5.
PaxDbiQ9NPA5.
PRIDEiQ9NPA5.

PTM databases

PhosphoSiteiQ9NPA5.

Expressioni

Gene expression databases

BgeeiQ9NPA5.
CleanExiHS_ZFP64.
ExpressionAtlasiQ9NPA5. baseline and differential.
GenevisibleiQ9NPA5. HS.

Organism-specific databases

HPAiHPA035112.
HPA058387.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
AENQ8WTP83EBI-711679,EBI-8637627
FAM124AQ86V423EBI-711679,EBI-744506
FHL2Q141923EBI-711679,EBI-701903
HEL164V9HWH03EBI-711679,EBI-10330301
TRIM41Q8WV443EBI-711679,EBI-725997

Protein-protein interaction databases

BioGridi120853. 24 interactions.
IntActiQ9NPA5. 9 interactions.
STRINGi9606.ENSP00000216923.

Structurei

Secondary structure

1
681
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Turni178 – 1803Combined sources
Helixi187 – 1937Combined sources
Helixi194 – 1963Combined sources
Beta strandi202 – 2043Combined sources
Beta strandi206 – 2083Combined sources
Beta strandi211 – 2144Combined sources
Helixi215 – 22410Combined sources
Beta strandi234 – 2374Combined sources
Beta strandi239 – 2424Combined sources
Helixi243 – 2508Combined sources
Beta strandi342 – 3443Combined sources
Beta strandi346 – 3494Combined sources
Beta strandi351 – 3544Combined sources
Helixi355 – 3628Combined sources
Helixi363 – 3653Combined sources
Beta strandi370 – 3723Combined sources
Beta strandi374 – 3774Combined sources
Beta strandi379 – 3824Combined sources
Helixi383 – 39412Combined sources
Beta strandi395 – 3973Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1X5WNMR-A341-397[»]
2DMDNMR-A174-256[»]
ProteinModelPortaliQ9NPA5.
SMRiQ9NPA5. Positions 138-449.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9NPA5.

Family & Domainsi

Sequence similaritiesi

Contains 9 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri175 – 19723C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri203 – 22523C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri231 – 25323C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri259 – 28123C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri287 – 31024C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri315 – 33723C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri343 – 36523C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri371 – 39424C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri425 – 44723C2H2-type 9PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG5048.
GeneTreeiENSGT00530000063079.
HOGENOMiHOG000230887.
HOVERGENiHBG056373.
InParanoidiQ9NPA5.
OrthoDBiEOG7XM2XF.
PhylomeDBiQ9NPA5.
TreeFamiTF333046.

Family and domain databases

Gene3Di3.30.160.60. 9 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 11 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 5 hits.
PS50157. ZINC_FINGER_C2H2_2. 9 hits.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9NPA5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNASSEGESF AGSVQIPGGT TVLVELTPDI HICGICKQQF NNLDAFVAHK
60 70 80 90 100
QSGCQLTGTS AAAPSTVQFV SEETVPATQT QTTTRTITSE TQTITVSAPE
110 120 130 140 150
FVFEHGYQTY LPTESNENQT ATVISLPAKS RTKKPTTPPA QKRLNCCYPG
160 170 180 190 200
CQFKTAYGMK DMERHLKIHT GDKPHKCEVC GKCFSRKDKL KTHMRCHTGV
210 220 230 240 250
KPYKCKTCDY AAADSSSLNK HLRIHSDERP FKCQICPYAS RNSSQLTVHL
260 270 280 290 300
RSHTGDAPFQ CWLCSAKFKI SSDLKRHMRV HSGEKPFKCE FCNVRCTMKG
310 320 330 340 350
NLKSHIRIKH SGNNFKCPHC DFLGDSKATL RKHSRVHQSE HPEKCSECSY
360 370 380 390 400
SCSSKAALRI HERIHCTDRP FKCNYCSFDT KQPSNLSKHM KKFHGDMVKT
410 420 430 440 450
EALERKDTGR QSSRQVAKLD AKKSFHCDIC DASFMREDSL RSHKRQHSEY
460 470 480 490 500
SESKNSDVTV LQFQIDPSKQ PATPLTVGHL QVPLQPSQVP QFSEGRVKII
510 520 530 540 550
VGHQVPQANT IVQAAAAAVN IVPPALVAQN PEELPGNSRL QILRQVSLIA
560 570 580 590 600
PPQSSRCPSE AGAMTQPAVL LTTHEQTDGA TLHQTLIPTA SGGPQEGSGN
610 620 630 640 650
QTFITSSGIT CTDFEGLNAL IQEGTAEVTV VSDGGQNIAV ATTAPPVFSS
660 670 680
SSQQELPKQT YSIIQGAAHP ALLCPADSIP D
Length:681
Mass (Da):74,644
Last modified:October 17, 2006 - v3
Checksum:i949C2DB54BB97E2E
GO
Isoform 2 (identifier: Q9NPA5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     96-149: Missing.

Show »
Length:627
Mass (Da):68,621
Checksum:iA4EE9B17845C00EF
GO
Isoform 3 (identifier: Q9NTW7-1) [UniParc]FASTAAdd to basket

The sequence of this isoform can be found in the external entry Q9NTW7.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:645
Mass (Da):72,217
GO
Isoform 4 (identifier: Q9NTW7-2) [UniParc]FASTAAdd to basket

Also known as: ZNF338

The sequence of this isoform can be found in the external entry Q9NTW7.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:426
Mass (Da):48,165
GO
Isoform 5 (identifier: Q9NTW7-3) [UniParc]FASTAAdd to basket

The sequence of this isoform can be found in the external entry Q9NTW7.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:415
Mass (Da):46,253
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti68 – 681Q → P.
Corresponds to variant rs7353222 [ dbSNP | Ensembl ].
VAR_028019
Natural varianti139 – 1391P → L.
Corresponds to variant rs6021773 [ dbSNP | Ensembl ].
VAR_028020
Natural varianti425 – 4251F → Y.
Corresponds to variant rs16996517 [ dbSNP | Ensembl ].
VAR_028021
Natural varianti451 – 4511S → N.2 Publications
Corresponds to variant rs3746414 [ dbSNP | Ensembl ].
VAR_028022

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei96 – 14954Missing in isoform 2. 1 PublicationVSP_007284Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK001596 mRNA. Translation: BAA91777.1.
AK001744 mRNA. Translation: BAA91876.1.
AL121771 Genomic DNA. Translation: CAB90276.1.
AL121771 Genomic DNA. Translation: CAB90277.1.
BC012759 mRNA. Translation: AAH12759.1.
BC041622 mRNA. Translation: AAH41622.1.
CCDSiCCDS13440.1. [Q9NPA5-1]
CCDS13441.1. [Q9NPA5-2]
RefSeqiNP_060667.2. NM_018197.2. [Q9NPA5-1]
NP_071371.3. NM_022088.4. [Q9NPA5-2]
NP_955458.1. NM_199426.1.
NP_955459.2. NM_199427.2.
UniGeneiHs.473082.

Genome annotation databases

EnsembliENST00000216923; ENSP00000216923; ENSG00000020256. [Q9NPA5-1]
ENST00000346617; ENSP00000344615; ENSG00000020256. [Q9NPA5-2]
GeneIDi55734.
KEGGihsa:55734.
UCSCiuc002xwl.3. human. [Q9NPA5-1]
uc002xwn.3. human. [Q9NPA5-2]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK001596 mRNA. Translation: BAA91777.1.
AK001744 mRNA. Translation: BAA91876.1.
AL121771 Genomic DNA. Translation: CAB90276.1.
AL121771 Genomic DNA. Translation: CAB90277.1.
BC012759 mRNA. Translation: AAH12759.1.
BC041622 mRNA. Translation: AAH41622.1.
CCDSiCCDS13440.1. [Q9NPA5-1]
CCDS13441.1. [Q9NPA5-2]
RefSeqiNP_060667.2. NM_018197.2. [Q9NPA5-1]
NP_071371.3. NM_022088.4. [Q9NPA5-2]
NP_955458.1. NM_199426.1.
NP_955459.2. NM_199427.2.
UniGeneiHs.473082.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1X5WNMR-A341-397[»]
2DMDNMR-A174-256[»]
ProteinModelPortaliQ9NPA5.
SMRiQ9NPA5. Positions 138-449.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120853. 24 interactions.
IntActiQ9NPA5. 9 interactions.
STRINGi9606.ENSP00000216923.

PTM databases

PhosphoSiteiQ9NPA5.

Polymorphism and mutation databases

BioMutaiSALL4.
DMDMi116242854.

Proteomic databases

MaxQBiQ9NPA5.
PaxDbiQ9NPA5.
PRIDEiQ9NPA5.

Protocols and materials databases

DNASUi55734.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000216923; ENSP00000216923; ENSG00000020256. [Q9NPA5-1]
ENST00000346617; ENSP00000344615; ENSG00000020256. [Q9NPA5-2]
GeneIDi55734.
KEGGihsa:55734.
UCSCiuc002xwl.3. human. [Q9NPA5-1]
uc002xwn.3. human. [Q9NPA5-2]

Organism-specific databases

CTDi55734.
GeneCardsiGC20M050668.
HGNCiHGNC:15940. ZFP64.
HPAiHPA035112.
HPA058387.
neXtProtiNX_Q9NPA5.
PharmGKBiPA38060.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG5048.
GeneTreeiENSGT00530000063079.
HOGENOMiHOG000230887.
HOVERGENiHBG056373.
InParanoidiQ9NPA5.
OrthoDBiEOG7XM2XF.
PhylomeDBiQ9NPA5.
TreeFamiTF333046.

Miscellaneous databases

EvolutionaryTraceiQ9NPA5.
GeneWikiiZFP64.
GenomeRNAii55734.
NextBioi60666.

Gene expression databases

BgeeiQ9NPA5.
CleanExiHS_ZFP64.
ExpressionAtlasiQ9NPA5. baseline and differential.
GenevisibleiQ9NPA5. HS.

Family and domain databases

Gene3Di3.30.160.60. 9 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 11 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 5 hits.
PS50157. ZINC_FINGER_C2H2_2. 9 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANT ASN-451.
    Tissue: Neuron.
  2. "The DNA sequence and comparative analysis of human chromosome 20."
    Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
    , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
    Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ASN-451.
    Tissue: Lymph.
  4. "Solution structure of the C2H2 type zinc-binding domain of human zinc finger protein 64, isoforms 1 and 2."
    RIKEN structural genomics initiative (RSGI)
    Submitted (MAY-2005) to the PDB data bank
    Cited for: STRUCTURE BY NMR OF 339-397, ZINC-BINDING SITES.

Entry informationi

Entry nameiZF64A_HUMAN
AccessioniPrimary (citable) accession number: Q9NPA5
Secondary accession number(s): Q9NTS7, Q9NVH4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 30, 2003
Last sequence update: October 17, 2006
Last modified: June 24, 2015
This is version 134 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.