Q9NPA5 (ZF64A_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Zinc finger protein 64 homolog, isoforms 1 and 2
Short name=Zfp-64

Alternative name(s):
Zinc finger protein 338

Gene names

Name:	ZFP64
Synonyms:	ZNF338

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	681 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May be involved in transcriptional regulation.
Subcellular location	Nucleus Probable.
Post-translational modification	Phosphorylated upon DNA damage, probably by ATM or ATR.
Sequence similarities	Belongs to the krueppel C2H2-type zinc-finger protein family. Contains 9 C2H2-type zinc fingers.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Repeat Zinc-finger
Ligand	DNA-binding Metal-binding Zinc
PTM	Phosphoprotein
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	DNA binding Inferred from electronic annotation. Source: UniProtKB-KW zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 5 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9NPA5-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9NPA5-2)

The sequence of this isoform differs from the canonical sequence as follows:
     96-149: Missing.

Isoform 3 (identifier: Q9NTW7-1)

The sequence of this isoform can be found in the external entry Q9NTW7.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.

Isoform 4 (identifier: Q9NTW7-2)

Also known as: ZNF338;

The sequence of this isoform can be found in the external entry Q9NTW7.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.

Isoform 5 (identifier: Q9NTW7-3)

The sequence of this isoform can be found in the external entry Q9NTW7.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 681

681

Zinc finger protein 64 homolog, isoforms 1 and 2

PRO_0000047307

Regions

Zinc finger

175 – 197

23

C2H2-type 1

Zinc finger

203 – 225

23

C2H2-type 2

Zinc finger

231 – 253

23

C2H2-type 3

Zinc finger

259 – 281

23

C2H2-type 4

Zinc finger

287 – 310

24

C2H2-type 5

Zinc finger

315 – 337

23

C2H2-type 6

Zinc finger

343 – 365

23

C2H2-type 7

Zinc finger

371 – 394

24

C2H2-type 8

Zinc finger

425 – 447

23

C2H2-type 9

Sites

Metal binding

345

1

Zinc 1

Metal binding

348

1

Zinc 1

Metal binding

361

1

Zinc 1

Metal binding

365

1

Zinc 1

Metal binding

373

1

Zinc 2

Metal binding

376

1

Zinc 2

Metal binding

389

1

Zinc 2

Metal binding

394

1

Zinc 2

Natural variations

Alternative sequence

96 – 149

54

Missing in isoform 2.

VSP_007284

Natural variant

68

1

Q → P.
Corresponds to variant rs7353222 [ dbSNP | Ensembl ].

VAR_028019

Natural variant

139

1

P → L.
Corresponds to variant rs6021773 [ dbSNP | Ensembl ].

VAR_028020

Natural variant

425

1

F → Y.
Corresponds to variant rs16996517 [ dbSNP | Ensembl ].

VAR_028021

Natural variant

451

1

S → N. Ref.1 Ref.3
Corresponds to variant rs3746414 [ dbSNP | Ensembl ].

VAR_028022

Secondary structure

1

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

681

Helix Strand Turn

Details...

Turn

178 – 180

3

Helix

187 – 193

7

Helix

194 – 196

3

Beta strand

202 – 204

3

Beta strand

206 – 208

3

Beta strand

211 – 214

4

Helix

215 – 224

10

Beta strand

234 – 237

4

Beta strand

239 – 242

4

Helix

243 – 250

8

Beta strand

342 – 344

3

Beta strand

346 – 349

4

Beta strand

351 – 354

4

Helix

355 – 362

8

Helix

363 – 365

3

Beta strand

370 – 372

3

Beta strand

374 – 377

4

Beta strand

379 – 382

4

Helix

383 – 394

12

Beta strand

395 – 397

3

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified October 17, 2006. Version 3. Checksum: 949C2DB54BB97E2E	FASTA	681	74,644
	10 20 30 40 50 60 MNASSEGESF AGSVQIPGGT TVLVELTPDI HICGICKQQF NNLDAFVAHK QSGCQLTGTS 70 80 90 100 110 120 AAAPSTVQFV SEETVPATQT QTTTRTITSE TQTITVSAPE FVFEHGYQTY LPTESNENQT 130 140 150 160 170 180 ATVISLPAKS RTKKPTTPPA QKRLNCCYPG CQFKTAYGMK DMERHLKIHT GDKPHKCEVC 190 200 210 220 230 240 GKCFSRKDKL KTHMRCHTGV KPYKCKTCDY AAADSSSLNK HLRIHSDERP FKCQICPYAS 250 260 270 280 290 300 RNSSQLTVHL RSHTGDAPFQ CWLCSAKFKI SSDLKRHMRV HSGEKPFKCE FCNVRCTMKG 310 320 330 340 350 360 NLKSHIRIKH SGNNFKCPHC DFLGDSKATL RKHSRVHQSE HPEKCSECSY SCSSKAALRI 370 380 390 400 410 420 HERIHCTDRP FKCNYCSFDT KQPSNLSKHM KKFHGDMVKT EALERKDTGR QSSRQVAKLD 430 440 450 460 470 480 AKKSFHCDIC DASFMREDSL RSHKRQHSEY SESKNSDVTV LQFQIDPSKQ PATPLTVGHL 490 500 510 520 530 540 QVPLQPSQVP QFSEGRVKII VGHQVPQANT IVQAAAAAVN IVPPALVAQN PEELPGNSRL 550 560 570 580 590 600 QILRQVSLIA PPQSSRCPSE AGAMTQPAVL LTTHEQTDGA TLHQTLIPTA SGGPQEGSGN 610 620 630 640 650 660 QTFITSSGIT CTDFEGLNAL IQEGTAEVTV VSDGGQNIAV ATTAPPVFSS SSQQELPKQT 670 680 YSIIQGAAHP ALLCPADSIP D
	Isoform 2 [UniParc]. Checksum: A4EE9B17845C00EF	FASTA	627	68,621
	10 20 30 40 50 60 MNASSEGESF AGSVQIPGGT TVLVELTPDI HICGICKQQF NNLDAFVAHK QSGCQLTGTS 70 80 90 100 110 120 AAAPSTVQFV SEETVPATQT QTTTRTITSE TQTITGCQFK TAYGMKDMER HLKIHTGDKP 130 140 150 160 170 180 HKCEVCGKCF SRKDKLKTHM RCHTGVKPYK CKTCDYAAAD SSSLNKHLRI HSDERPFKCQ 190 200 210 220 230 240 ICPYASRNSS QLTVHLRSHT GDAPFQCWLC SAKFKISSDL KRHMRVHSGE KPFKCEFCNV 250 260 270 280 290 300 RCTMKGNLKS HIRIKHSGNN FKCPHCDFLG DSKATLRKHS RVHQSEHPEK CSECSYSCSS 310 320 330 340 350 360 KAALRIHERI HCTDRPFKCN YCSFDTKQPS NLSKHMKKFH GDMVKTEALE RKDTGRQSSR 370 380 390 400 410 420 QVAKLDAKKS FHCDICDASF MREDSLRSHK RQHSEYSESK NSDVTVLQFQ IDPSKQPATP 430 440 450 460 470 480 LTVGHLQVPL QPSQVPQFSE GRVKIIVGHQ VPQANTIVQA AAAAVNIVPP ALVAQNPEEL 490 500 510 520 530 540 PGNSRLQILR QVSLIAPPQS SRCPSEAGAM TQPAVLLTTH EQTDGATLHQ TLIPTASGGP 550 560 570 580 590 600 QEGSGNQTFI TSSGITCTDF EGLNALIQEG TAEVTVVSDG GQNIAVATTA PPVFSSSSQQ 610 620 ELPKQTYSII QGAAHPALLC PADSIPD
	Isoform 3 [UniParc]. See Q9NTW7.		–	–
	Isoform 4 (ZNF338) [UniParc]. See Q9NTW7.		–	–
	Isoform 5 [UniParc]. See Q9NTW7.		–	–

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANT ASN-451. Tissue: Neuron.
[2]	"The DNA sequence and comparative analysis of human chromosome 20." Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E. , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J. Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ASN-451. Tissue: Lymph.
[4]	"Solution structure of the C2H2 type zinc-binding domain of human zinc finger protein 64, isoforms 1 and 2." RIKEN structural genomics initiative (RSGI) Submitted (MAY-2005) to the PDB data bank Cited for: STRUCTURE BY NMR OF 339-397, ZINC-BINDING SITES.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AK001596 mRNA. Translation: BAA91777.1.
AK001744 mRNA. Translation: BAA91876.1.
AL121771 Genomic DNA. Translation: CAB90276.1.
AL121771 Genomic DNA. Translation: CAB90277.1.
BC012759 mRNA. Translation: AAH12759.1.
BC041622 mRNA. Translation: AAH41622.1.

IPI

IPI00018906.
IPI00254471.

RefSeq

NP_060667.2. NM_018197.2.
NP_071371.3. NM_022088.4.
NP_955458.1. NM_199426.1.
NP_955459.2. NM_199427.2.

UniGene

Hs.473082.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1X5W	NMR	-	A	341-397	[»]
2DMD	NMR	-	A	174-256	[»]

ProteinModelPortal

Q9NPA5.

ModBase

Search...

Protein-protein interaction databases

IntAct

Q9NPA5. 4 interactions.

STRING

9606.ENSP00000216923.

PTM databases

PhosphoSite

Q9NPA5.

Polymorphism databases

DMDM

116242854.

Proteomic databases

PaxDb

Q9NPA5.

PRIDE

Q9NPA5.

Protocols and materials databases

DNASU

55734.

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000216923; ENSP00000216923; ENSG00000020256.
ENST00000346617; ENSP00000344615; ENSG00000020256.

GeneID

55734.

KEGG

hsa:55734.

UCSC

uc002xwl.3. human.
uc002xwn.3. human.

Organism-specific databases

CTD

55734.

GeneCards

GC20M050668.

HGNC

HGNC:15940. ZFP64.

HPA

HPA035112.

neXtProt

NX_Q9NPA5.

PharmGKB

PA38060.

GenAtlas

Search...

Phylogenomic databases

eggNOG

COG5048.

HOGENOM

HOG000230887.

HOVERGEN

HBG056373.

InParanoid

Q9NPA5.

PhylomeDB

Q9NPA5.

Gene expression databases

ArrayExpress

Q9NPA5.

Bgee

Q9NPA5.

CleanEx

HS_ZFP64.

Genevestigator

Q9NPA5.

GermOnline

ENSG00000020256. Homo sapiens.

Family and domain databases

Gene3D

3.30.160.60. 9 hits.

InterPro

IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]

SMART

SM00355. ZnF_C2H2. 11 hits.
[Graphical view]

PROSITE

PS00028. ZINC_FINGER_C2H2_1. 5 hits.
PS50157. ZINC_FINGER_C2H2_2. 9 hits.
[Graphical view]

ProtoNet

Search...

Other

EvolutionaryTrace

Q9NPA5.

GenomeRNAi

55734.

NextBio

60666.

Entry information

Entry name

ZF64A_HUMAN

Accession

Primary (citable) accession number: Q9NPA5
Secondary accession number(s): Q9NTS7, Q9NVH4

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 30, 2003
Last sequence update:	October 17, 2006
Last modified:	May 1, 2013
This is version 114 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.