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Q9NPA3

- M1IP1_HUMAN

UniProt

Q9NPA3 - M1IP1_HUMAN

Protein

Mid1-interacting protein 1

Gene

MID1IP1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 103 (01 Oct 2014)
      Sequence version 1 (01 Oct 2000)
      Previous versions | rss
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    Functioni

    Plays a role in the regulation of lipogenesis in liver. Up-regulates ACACA enzyme activity. Required for efficient lipid biosynthesis, including triacylglycerol, diacylglycerol and phospholipid. Involved in stabilization of microtubules By similarity.By similarity

    GO - Biological processi

    1. lipid metabolic process Source: UniProtKB-KW
    2. negative regulation of microtubule depolymerization Source: UniProtKB
    3. positive regulation of fatty acid biosynthetic process Source: UniProtKB
    4. positive regulation of ligase activity Source: UniProtKB
    5. protein polymerization Source: UniProtKB
    6. regulation of lipid biosynthetic process Source: UniProtKB

    Keywords - Biological processi

    Lipid biosynthesis, Lipid metabolism

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Mid1-interacting protein 1
    Alternative name(s):
    Gastrulation-specific G12-like protein
    Mid1-interacting G12-like protein
    Protein STRAIT11499
    Spot 14-related protein
    Short name:
    S14R
    Short name:
    Spot 14-R
    Gene namesi
    Name:MID1IP1
    Synonyms:MIG12
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome X

    Organism-specific databases

    HGNCiHGNC:20715. MID1IP1.

    Subcellular locationi

    Nucleus By similarity. Cytoplasm By similarity. Cytoplasmcytoskeleton By similarity
    Note: Associated with microtubules.By similarity

    GO - Cellular componenti

    1. cytosol Source: UniProtKB
    2. microtubule Source: UniProtKB-KW
    3. microtubule cytoskeleton Source: UniProtKB
    4. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Cytoskeleton, Microtubule, Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134941916.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 183183Mid1-interacting protein 1PRO_0000123777Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1 – 11N-acetylmethionine1 Publication
    Modified residuei75 – 751PhosphoserineBy similarity

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiQ9NPA3.
    PaxDbiQ9NPA3.
    PRIDEiQ9NPA3.

    PTM databases

    PhosphoSiteiQ9NPA3.

    Expressioni

    Gene expression databases

    BgeeiQ9NPA3.
    CleanExiHS_MID1IP1.
    GenevestigatoriQ9NPA3.

    Organism-specific databases

    HPAiHPA038816.

    Interactioni

    Subunit structurei

    Homodimer in the absence of THRSP. Heterodimer with THRSP. The homodimer interacts with ACACA and ACACB. Promotes polymerization of Acetyl-CoA carboxylase to form complexes that contain MID1IP1 and ACACA and/or ACACB. Interaction with THRSP interferes with ACACA binding By similarity.By similarity

    Protein-protein interaction databases

    BioGridi121846. 5 interactions.
    IntActiQ9NPA3. 2 interactions.
    MINTiMINT-1445333.
    STRINGi9606.ENSP00000338706.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9NPA3.
    SMRiQ9NPA3. Positions 11-177.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the SPOT14 family.Curated

    Phylogenomic databases

    eggNOGiNOG42079.
    HOGENOMiHOG000001157.
    HOVERGENiHBG002528.
    InParanoidiQ9NPA3.
    OMAiGFSNWGH.
    OrthoDBiEOG7K6PW4.
    PhylomeDBiQ9NPA3.
    TreeFamiTF326826.

    Family and domain databases

    InterProiIPR009786. Spot_14.
    [Graphical view]
    PANTHERiPTHR14315. PTHR14315. 1 hit.
    PfamiPF07084. Spot_14. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9NPA3-1 [UniParc]FASTAAdd to Basket

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    MMQICDTYNQ KHSLFNAMNR FIGAVNNMDQ TVMVPSLLRD VPLADPGLDN    50
    DVGVEVGGSG GCLEERTPPV PDSGSANGSF FAPSRDMYSH YVLLKSIRND 100
    IEWGVLHQPP PPAGSEEGSA WKSKDILVDL GHLEGADAGE EDLEQQFHYH 150
    LRGLHTVLSK LTRKANILTN RYKQEIGFGN WGH 183
    Length:183
    Mass (Da):20,202
    Last modified:October 1, 2000 - v1
    Checksum:iA62D5924A7B17D5F
    GO

    Sequence cautioni

    The sequence DAA01482.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ272057 mRNA. Translation: CAB89113.1.
    AK001248 mRNA. Translation: BAA91580.1.
    CR457220 mRNA. Translation: CAG33501.1.
    CH471141 Genomic DNA. Translation: EAW59435.1.
    CH471141 Genomic DNA. Translation: EAW59436.1.
    BC008908 mRNA. Translation: AAH08908.1.
    BC019332 mRNA. Translation: AAH19332.1.
    BK001260 mRNA. Translation: DAA01482.1. Different initiation.
    CCDSiCCDS14249.1.
    RefSeqiNP_001092260.1. NM_001098790.1.
    NP_001092261.1. NM_001098791.1.
    NP_067065.1. NM_021242.5.
    UniGeneiHs.522605.
    Hs.662789.

    Genome annotation databases

    EnsembliENST00000336949; ENSP00000338706; ENSG00000165175.
    ENST00000378474; ENSP00000367735; ENSG00000165175.
    ENST00000457894; ENSP00000416670; ENSG00000165175.
    GeneIDi58526.
    KEGGihsa:58526.
    UCSCiuc004dei.4. human.

    Polymorphism databases

    DMDMi21759081.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ272057 mRNA. Translation: CAB89113.1 .
    AK001248 mRNA. Translation: BAA91580.1 .
    CR457220 mRNA. Translation: CAG33501.1 .
    CH471141 Genomic DNA. Translation: EAW59435.1 .
    CH471141 Genomic DNA. Translation: EAW59436.1 .
    BC008908 mRNA. Translation: AAH08908.1 .
    BC019332 mRNA. Translation: AAH19332.1 .
    BK001260 mRNA. Translation: DAA01482.1 . Different initiation.
    CCDSi CCDS14249.1.
    RefSeqi NP_001092260.1. NM_001098790.1.
    NP_001092261.1. NM_001098791.1.
    NP_067065.1. NM_021242.5.
    UniGenei Hs.522605.
    Hs.662789.

    3D structure databases

    ProteinModelPortali Q9NPA3.
    SMRi Q9NPA3. Positions 11-177.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 121846. 5 interactions.
    IntActi Q9NPA3. 2 interactions.
    MINTi MINT-1445333.
    STRINGi 9606.ENSP00000338706.

    PTM databases

    PhosphoSitei Q9NPA3.

    Polymorphism databases

    DMDMi 21759081.

    Proteomic databases

    MaxQBi Q9NPA3.
    PaxDbi Q9NPA3.
    PRIDEi Q9NPA3.

    Protocols and materials databases

    DNASUi 58526.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000336949 ; ENSP00000338706 ; ENSG00000165175 .
    ENST00000378474 ; ENSP00000367735 ; ENSG00000165175 .
    ENST00000457894 ; ENSP00000416670 ; ENSG00000165175 .
    GeneIDi 58526.
    KEGGi hsa:58526.
    UCSCi uc004dei.4. human.

    Organism-specific databases

    CTDi 58526.
    GeneCardsi GC0XP038660.
    HGNCi HGNC:20715. MID1IP1.
    HPAi HPA038816.
    neXtProti NX_Q9NPA3.
    PharmGKBi PA134941916.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG42079.
    HOGENOMi HOG000001157.
    HOVERGENi HBG002528.
    InParanoidi Q9NPA3.
    OMAi GFSNWGH.
    OrthoDBi EOG7K6PW4.
    PhylomeDBi Q9NPA3.
    TreeFami TF326826.

    Miscellaneous databases

    GenomeRNAii 58526.
    NextBioi 65082.
    PROi Q9NPA3.

    Gene expression databases

    Bgeei Q9NPA3.
    CleanExi HS_MID1IP1.
    Genevestigatori Q9NPA3.

    Family and domain databases

    InterProi IPR009786. Spot_14.
    [Graphical view ]
    PANTHERi PTHR14315. PTHR14315. 1 hit.
    Pfami PF07084. Spot_14. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Full-length sequencing of some human and murine muscular transcripts (Telethon Italy project B41)."
      Frigimelica E., Lanfranchi G.
      Submitted (FEB-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Skeletal muscle.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    3. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
      Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Lymph and Placenta.
    6. "Mig12, a novel Opitz syndrome gene product partner, is expressed in the embryonic ventral midline and co-operates with Mid1 to bundle and stabilize microtubules."
      Berti C., Fontanella B., Ferrentino R., Meroni G.
      BMC Cell Biol. 5:9-9(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION.
    7. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiM1IP1_HUMAN
    AccessioniPrimary (citable) accession number: Q9NPA3
    Secondary accession number(s): D3DWB2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 11, 2002
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 103 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Caution

    It is uncertain whether Met-1 or Met-2 is the initiator.Curated

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome X
      Human chromosome X: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3