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Q9NPA3 (M1IP1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 102. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Mid1-interacting protein 1
Alternative name(s):
Gastrulation-specific G12-like protein
Mid1-interacting G12-like protein
Protein STRAIT11499
Spot 14-related protein
Short name=S14R
Short name=Spot 14-R
Gene names
Name:MID1IP1
Synonyms:MIG12
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length183 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Plays a role in the regulation of lipogenesis in liver. Up-regulates ACACA enzyme activity. Required for efficient lipid biosynthesis, including triacylglycerol, diacylglycerol and phospholipid. Involved in stabilization of microtubules By similarity.

Subunit structure

Homodimer in the absence of THRSP. Heterodimer with THRSP. The homodimer interacts with ACACA and ACACB. Promotes polymerization of Acetyl-CoA carboxylase to form complexes that contain MID1IP1 and ACACA and/or ACACB. Interaction with THRSP interferes with ACACA binding By similarity.

Subcellular location

Nucleus By similarity. Cytoplasm By similarity. Cytoplasmcytoskeleton By similarity. Note: Associated with microtubules By similarity.

Sequence similarities

Belongs to the SPOT14 family.

Caution

It is uncertain whether Met-1 or Met-2 is the initiator.

Sequence caution

The sequence DAA01482.1 differs from that shown. Reason: Erroneous initiation.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 183183Mid1-interacting protein 1
PRO_0000123777

Amino acid modifications

Modified residue11N-acetylmethionine Ref.7
Modified residue751Phosphoserine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9NPA3 [UniParc].

Last modified October 1, 2000. Version 1.
Checksum: A62D5924A7B17D5F

FASTA18320,202
        10         20         30         40         50         60 
MMQICDTYNQ KHSLFNAMNR FIGAVNNMDQ TVMVPSLLRD VPLADPGLDN DVGVEVGGSG 

        70         80         90        100        110        120 
GCLEERTPPV PDSGSANGSF FAPSRDMYSH YVLLKSIRND IEWGVLHQPP PPAGSEEGSA 

       130        140        150        160        170        180 
WKSKDILVDL GHLEGADAGE EDLEQQFHYH LRGLHTVLSK LTRKANILTN RYKQEIGFGN 


WGH 

« Hide

References

« Hide 'large scale' references
[1]"Full-length sequencing of some human and murine muscular transcripts (Telethon Italy project B41)."
Frigimelica E., Lanfranchi G.
Submitted (FEB-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Skeletal muscle.
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Lymph and Placenta.
[6]"Mig12, a novel Opitz syndrome gene product partner, is expressed in the embryonic ventral midline and co-operates with Mid1 to bundle and stabilize microtubules."
Berti C., Fontanella B., Ferrentino R., Meroni G.
BMC Cell Biol. 5:9-9(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION.
[7]"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ272057 mRNA. Translation: CAB89113.1.
AK001248 mRNA. Translation: BAA91580.1.
CR457220 mRNA. Translation: CAG33501.1.
CH471141 Genomic DNA. Translation: EAW59435.1.
CH471141 Genomic DNA. Translation: EAW59436.1.
BC008908 mRNA. Translation: AAH08908.1.
BC019332 mRNA. Translation: AAH19332.1.
BK001260 mRNA. Translation: DAA01482.1. Different initiation.
CCDSCCDS14249.1.
RefSeqNP_001092260.1. NM_001098790.1.
NP_001092261.1. NM_001098791.1.
NP_067065.1. NM_021242.5.
UniGeneHs.522605.
Hs.662789.

3D structure databases

ProteinModelPortalQ9NPA3.
SMRQ9NPA3. Positions 11-177.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid121846. 5 interactions.
IntActQ9NPA3. 2 interactions.
MINTMINT-1445333.
STRING9606.ENSP00000338706.

PTM databases

PhosphoSiteQ9NPA3.

Polymorphism databases

DMDM21759081.

Proteomic databases

MaxQBQ9NPA3.
PaxDbQ9NPA3.
PRIDEQ9NPA3.

Protocols and materials databases

DNASU58526.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000336949; ENSP00000338706; ENSG00000165175.
ENST00000378474; ENSP00000367735; ENSG00000165175.
ENST00000457894; ENSP00000416670; ENSG00000165175.
GeneID58526.
KEGGhsa:58526.
UCSCuc004dei.4. human.

Organism-specific databases

CTD58526.
GeneCardsGC0XP038660.
HGNCHGNC:20715. MID1IP1.
HPAHPA038816.
neXtProtNX_Q9NPA3.
PharmGKBPA134941916.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG42079.
HOGENOMHOG000001157.
HOVERGENHBG002528.
InParanoidQ9NPA3.
OMAGFSNWGH.
OrthoDBEOG7K6PW4.
PhylomeDBQ9NPA3.
TreeFamTF326826.

Gene expression databases

BgeeQ9NPA3.
CleanExHS_MID1IP1.
GenevestigatorQ9NPA3.

Family and domain databases

InterProIPR009786. Spot_14.
[Graphical view]
PANTHERPTHR14315. PTHR14315. 1 hit.
PfamPF07084. Spot_14. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi58526.
NextBio65082.
PROQ9NPA3.

Entry information

Entry nameM1IP1_HUMAN
AccessionPrimary (citable) accession number: Q9NPA3
Secondary accession number(s): D3DWB2
Entry history
Integrated into UniProtKB/Swiss-Prot: July 11, 2002
Last sequence update: October 1, 2000
Last modified: July 9, 2014
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human chromosome X

Human chromosome X: entries, gene names and cross-references to MIM