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Q9NPA1

- KCMB3_HUMAN

UniProt

Q9NPA1 - KCMB3_HUMAN

Protein

Calcium-activated potassium channel subunit beta-3

Gene

KCNMB3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
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    • History
      Entry version 113 (01 Oct 2014)
      Sequence version 2 (07 Mar 2006)
      Previous versions | rss
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    Functioni

    Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Alters the functional properties of the current expressed by the KCNMA1 channel. Isoform 2, isoform 3 and isoform 4 partially inactivate the current of KCNBMA. Isoform 4 induces a fast and incomplete inactivation of KCNMA1 channel that is detectable only at large depolarizations. In contrast, isoform 1 does not induce detectable inactivation of KCNMA1. Two or more subunits of KCNMB3 are required to block the KCNMA1 tetramer.2 Publications

    GO - Molecular functioni

    1. calcium-activated potassium channel activity Source: UniProtKB
    2. potassium channel regulator activity Source: UniProtKB

    GO - Biological processi

    1. action potential Source: UniProtKB
    2. blood coagulation Source: Reactome
    3. detection of calcium ion Source: UniProtKB
    4. neuronal action potential Source: UniProtKB
    5. potassium ion transmembrane transport Source: GOC
    6. potassium ion transport Source: UniProtKB
    7. synaptic transmission Source: Reactome

    Keywords - Molecular functioni

    Ion channel

    Keywords - Biological processi

    Ion transport, Transport

    Enzyme and pathway databases

    ReactomeiREACT_23767. cGMP effects.
    REACT_75896. Ca2+ activated K+ channels.

    Protein family/group databases

    TCDBi8.A.14.1.4. the ca(2+)-activated k(+) channel auxiliary subunit slowpoke- (slo) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Calcium-activated potassium channel subunit beta-3
    Alternative name(s):
    BK channel subunit beta-3
    Short name:
    BKbeta3
    Short name:
    Hbeta3
    Calcium-activated potassium channel, subfamily M subunit beta-3
    Charybdotoxin receptor subunit beta-3
    K(VCA)beta-3
    Maxi K channel subunit beta-3
    Slo-beta-3
    Gene namesi
    Name:KCNMB3
    Synonyms:KCNMB2, KCNMBL
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 3

    Organism-specific databases

    HGNCiHGNC:6287. KCNMB3.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of plasma membrane Source: UniProtKB
    2. plasma membrane Source: Reactome
    3. voltage-gated potassium channel complex Source: UniProtKB

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA30067.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 279279Calcium-activated potassium channel subunit beta-3PRO_0000187054Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi131 – 1311N-linked (GlcNAc...)Sequence Analysis

    Post-translational modificationi

    N-glycosylated.1 Publication
    The extracellular domain contains disulfide bond essential for the gating mechanism.

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ9NPA1.
    PRIDEiQ9NPA1.

    Expressioni

    Tissue specificityi

    Isoform 1, isoform 3 and isoform 4 are widely expressed. Isoform 2 is expressed placenta, pancreas, kidney and heart. Isoform 1 and isoform 3 are highly expressed in pancreas and testis.3 Publications

    Gene expression databases

    BgeeiQ9NPA1.
    CleanExiHS_KCNMB2.
    HS_KCNMB3.
    GenevestigatoriQ9NPA1.

    Organism-specific databases

    HPAiHPA015665.
    HPA019185.

    Interactioni

    Subunit structurei

    Interacts with KCNMA1 tetramer. There are probably 4 molecules of KCMNB3 per KCNMA1 tetramer.1 Publication

    Protein-protein interaction databases

    STRINGi9606.ENSP00000319370.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9NPA1.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 6060CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini82 – 207126ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini229 – 27951CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei61 – 8121Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei208 – 22821Helical; Name=2Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domaini

    Isoform 4 cytoplasmic N-terminal domain participates in the partial inactivation of KCNMA1, possibly by binding to a receptor site.
    The extracellular domain forms gates to block ion permeation, providing a mechanism by which current can be rapidly diminished upon cellular repolarization.

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG29303.
    HOGENOMiHOG000290180.
    HOVERGENiHBG108059.
    InParanoidiQ9NPA1.
    KOiK04939.
    OMAiNEEPNEL.
    OrthoDBiEOG77WWDC.
    PhylomeDBiQ9NPA1.
    TreeFamiTF328589.

    Family and domain databases

    InterProiIPR003930. K_chnl_Ca-activ_BK_bsu.
    [Graphical view]
    PANTHERiPTHR10258. PTHR10258. 1 hit.
    PfamiPF03185. CaKB. 1 hit.
    [Graphical view]

    Sequences (5)i

    Sequence statusi: Complete.

    This entry describes 5 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9NPA1-1) [UniParc]FASTAAdd to Basket

    Also known as: 3d

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MDFSPSSELG FHFVAFILLT RHRTAFPASG KKRETDYSDG DPLDVHKRLP    50
    SSAGEDRAVM LGFAMMGFSV LMFFLLGTTI LKPFMLSIQR EESTCTAIHT 100
    DIMDDWLDCA FTCGVHCHGQ GKYPCLQVFV NLSHPGQKAL LHYNEEAVQI 150
    NPKCFYTPKC HQDRNDLLNS ALDIKEFFDH KNGTPFSCFY SPASQSEDVI 200
    LIKKYDQMAI FHCLFWPSLT LLGGALIVGM VRLTQHLSLL CEKYSTVVRD 250
    EVGGKVPYIE QHQFKLCIMR RSKGRAEKS 279
    Length:279
    Mass (Da):31,604
    Last modified:March 7, 2006 - v2
    Checksum:iEC5F0D5D3E040C4C
    GO
    Isoform 2 (identifier: Q9NPA1-2) [UniParc]FASTAAdd to Basket

    Also known as: 3a

    The sequence of this isoform differs from the canonical sequence as follows:
         1-22: MDFSPSSELGFHFVAFILLTRH → MQPFSIPVQITLQGSRRRQG

    Show »
    Length:277
    Mass (Da):31,351
    Checksum:iEBF06FF8686F0655
    GO
    Isoform 3 (identifier: Q9NPA1-3) [UniParc]FASTAAdd to Basket

    Also known as: 3c

    The sequence of this isoform differs from the canonical sequence as follows:
         1-22: MDFSPSSELGFHFVAFILLTRH → MFPLLYELTAVSPSPFPQ

    Show »
    Length:275
    Mass (Da):31,089
    Checksum:i9C7C5A523D37D5C2
    GO
    Isoform 4 (identifier: Q9NPA1-4) [UniParc]FASTAAdd to Basket

    Also known as: 3b

    The sequence of this isoform differs from the canonical sequence as follows:
         1-22: Missing.
         23-23: R → M

    Show »
    Length:257
    Mass (Da):29,045
    Checksum:i0B5D59CB0551295D
    GO
    Isoform 5 (identifier: Q9NPA1-5) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-22: MDFSPSSELGFHFVAFILLTRH → MQPFSIPVQITLQGSRRRQG
         154-175: CFYTPKCHQDRNDLLNSALDIK → RDVTDCRVKEKQTLTVSDEHKQ
         176-279: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:173
    Mass (Da):19,474
    Checksum:i7EACEF7D7202F1B8
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti24 – 241T → P in BAH14265. (PubMed:14702039)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti44 – 441D → G.
    Corresponds to variant rs1170672 [ dbSNP | Ensembl ].
    VAR_018173
    Natural varianti53 – 531A → T.5 Publications
    Corresponds to variant rs7645550 [ dbSNP | Ensembl ].
    VAR_018174
    Natural varianti75 – 751L → V.1 Publication
    Corresponds to variant rs2276802 [ dbSNP | Ensembl ].
    VAR_018175
    Natural varianti165 – 1651N → S.2 Publications
    Corresponds to variant rs139527128 [ dbSNP | Ensembl ].
    VAR_018176
    Natural varianti230 – 2301M → T.1 Publication
    VAR_018177

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 2222MDFSP…LLTRH → MQPFSIPVQITLQGSRRRQG in isoform 2 and isoform 5. 1 PublicationVSP_009827Add
    BLAST
    Alternative sequencei1 – 2222MDFSP…LLTRH → MFPLLYELTAVSPSPFPQ in isoform 3. 1 PublicationVSP_009828Add
    BLAST
    Alternative sequencei1 – 2222Missing in isoform 4. 2 PublicationsVSP_009829Add
    BLAST
    Alternative sequencei23 – 231R → M in isoform 4. 2 PublicationsVSP_009830
    Alternative sequencei154 – 17522CFYTP…ALDIK → RDVTDCRVKEKQTLTVSDEH KQ in isoform 5. 1 PublicationVSP_046090Add
    BLAST
    Alternative sequencei176 – 279104Missing in isoform 5. 1 PublicationVSP_046091Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF139471 mRNA. Translation: AAD54771.1.
    AF214561 mRNA. Translation: AAF36598.1.
    AF204159 Genomic DNA. Translation: AAF97031.1.
    AF204160 Genomic DNA. Translation: AAF97032.1.
    AF204161 Genomic DNA. Translation: AAF97033.1.
    AF204162 Genomic DNA. Translation: AAF97034.1.
    AF160968 mRNA. Translation: AAF67811.1.
    AF170916 mRNA. Translation: AAF89698.1.
    AK304837 mRNA. Translation: BAH14265.1.
    AC007823 Genomic DNA. No translation available.
    AC076966 Genomic DNA. No translation available.
    CH471052 Genomic DNA. Translation: EAW78418.1.
    CH471052 Genomic DNA. Translation: EAW78421.1.
    CCDSiCCDS3225.1. [Q9NPA1-2]
    CCDS3226.1. [Q9NPA1-1]
    CCDS43172.1. [Q9NPA1-4]
    CCDS43173.1. [Q9NPA1-3]
    CCDS54683.1. [Q9NPA1-5]
    RefSeqiNP_001157149.1. NM_001163677.1. [Q9NPA1-5]
    NP_055222.3. NM_014407.3. [Q9NPA1-1]
    NP_741979.1. NM_171828.2. [Q9NPA1-2]
    NP_741980.1. NM_171829.2. [Q9NPA1-4]
    NP_741981.1. NM_171830.1. [Q9NPA1-3]
    UniGeneiHs.591285.

    Genome annotation databases

    EnsembliENST00000314235; ENSP00000319370; ENSG00000171121. [Q9NPA1-1]
    ENST00000349697; ENSP00000327866; ENSG00000171121. [Q9NPA1-2]
    ENST00000392685; ENSP00000376451; ENSG00000171121. [Q9NPA1-3]
    ENST00000392686; ENSP00000376452; ENSG00000171121. [Q9NPA1-4]
    ENST00000485523; ENSP00000418536; ENSG00000171121. [Q9NPA1-4]
    ENST00000497599; ENSP00000417091; ENSG00000171121. [Q9NPA1-5]
    GeneIDi27094.
    KEGGihsa:27094.
    UCSCiuc003fjm.3. human. [Q9NPA1-1]
    uc003fjn.3. human. [Q9NPA1-3]
    uc003fjo.3. human. [Q9NPA1-4]
    uc003fjp.1. human. [Q9NPA1-2]

    Polymorphism databases

    DMDMi90111824.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF139471 mRNA. Translation: AAD54771.1 .
    AF214561 mRNA. Translation: AAF36598.1 .
    AF204159 Genomic DNA. Translation: AAF97031.1 .
    AF204160 Genomic DNA. Translation: AAF97032.1 .
    AF204161 Genomic DNA. Translation: AAF97033.1 .
    AF204162 Genomic DNA. Translation: AAF97034.1 .
    AF160968 mRNA. Translation: AAF67811.1 .
    AF170916 mRNA. Translation: AAF89698.1 .
    AK304837 mRNA. Translation: BAH14265.1 .
    AC007823 Genomic DNA. No translation available.
    AC076966 Genomic DNA. No translation available.
    CH471052 Genomic DNA. Translation: EAW78418.1 .
    CH471052 Genomic DNA. Translation: EAW78421.1 .
    CCDSi CCDS3225.1. [Q9NPA1-2 ]
    CCDS3226.1. [Q9NPA1-1 ]
    CCDS43172.1. [Q9NPA1-4 ]
    CCDS43173.1. [Q9NPA1-3 ]
    CCDS54683.1. [Q9NPA1-5 ]
    RefSeqi NP_001157149.1. NM_001163677.1. [Q9NPA1-5 ]
    NP_055222.3. NM_014407.3. [Q9NPA1-1 ]
    NP_741979.1. NM_171828.2. [Q9NPA1-2 ]
    NP_741980.1. NM_171829.2. [Q9NPA1-4 ]
    NP_741981.1. NM_171830.1. [Q9NPA1-3 ]
    UniGenei Hs.591285.

    3D structure databases

    ProteinModelPortali Q9NPA1.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000319370.

    Protein family/group databases

    TCDBi 8.A.14.1.4. the ca(2+)-activated k(+) channel auxiliary subunit slowpoke- (slo) family.

    Polymorphism databases

    DMDMi 90111824.

    Proteomic databases

    PaxDbi Q9NPA1.
    PRIDEi Q9NPA1.

    Protocols and materials databases

    DNASUi 27094.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000314235 ; ENSP00000319370 ; ENSG00000171121 . [Q9NPA1-1 ]
    ENST00000349697 ; ENSP00000327866 ; ENSG00000171121 . [Q9NPA1-2 ]
    ENST00000392685 ; ENSP00000376451 ; ENSG00000171121 . [Q9NPA1-3 ]
    ENST00000392686 ; ENSP00000376452 ; ENSG00000171121 . [Q9NPA1-4 ]
    ENST00000485523 ; ENSP00000418536 ; ENSG00000171121 . [Q9NPA1-4 ]
    ENST00000497599 ; ENSP00000417091 ; ENSG00000171121 . [Q9NPA1-5 ]
    GeneIDi 27094.
    KEGGi hsa:27094.
    UCSCi uc003fjm.3. human. [Q9NPA1-1 ]
    uc003fjn.3. human. [Q9NPA1-3 ]
    uc003fjo.3. human. [Q9NPA1-4 ]
    uc003fjp.1. human. [Q9NPA1-2 ]

    Organism-specific databases

    CTDi 27094.
    GeneCardsi GC03M178957.
    HGNCi HGNC:6287. KCNMB3.
    HPAi HPA015665.
    HPA019185.
    MIMi 605222. gene.
    neXtProti NX_Q9NPA1.
    PharmGKBi PA30067.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG29303.
    HOGENOMi HOG000290180.
    HOVERGENi HBG108059.
    InParanoidi Q9NPA1.
    KOi K04939.
    OMAi NEEPNEL.
    OrthoDBi EOG77WWDC.
    PhylomeDBi Q9NPA1.
    TreeFami TF328589.

    Enzyme and pathway databases

    Reactomei REACT_23767. cGMP effects.
    REACT_75896. Ca2+ activated K+ channels.

    Miscellaneous databases

    GeneWikii KCNMB3.
    GenomeRNAii 27094.
    NextBioi 49727.
    PROi Q9NPA1.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9NPA1.
    CleanExi HS_KCNMB2.
    HS_KCNMB3.
    Genevestigatori Q9NPA1.

    Family and domain databases

    InterProi IPR003930. K_chnl_Ca-activ_BK_bsu.
    [Graphical view ]
    PANTHERi PTHR10258. PTHR10258. 1 hit.
    Pfami PF03185. CaKB. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification of a putative regulatory subunit of a calcium-activated potassium channel in the dup(3q) syndrome region and a related sequence on 22q11.2."
      Riazi M.A., Brinkman-Mills P., Johnson A., Naylor S.L., Minoshima S., Shimizu N., Baldini A., McDermid H.E.
      Genomics 62:90-94(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3), VARIANT THR-53, TISSUE SPECIFICITY.
    2. "Cloning and functional characterization of novel large conductance calcium-activated potassium channel beta subunits, hKCNMB3 and hKCNMB4."
      Brenner R., Jegla T.J., Wickenden A., Liu Y., Aldrich R.W.
      J. Biol. Chem. 275:6453-6461(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4), VARIANT THR-53, TISSUE SPECIFICITY, INTERACTION WITH KCNMA1.
      Tissue: Brain.
    3. "Cloning and functional expression of two families of Beta-subunits of the large conductance calcium-activated potassium channel."
      Uebele V.N., Lagrutta A.A., Wade T., Figueroa D.J., Liu Y., McKenna E., Austin C.P., Bennett P.B., Swanson R.
      J. Biol. Chem. 275:23211-23218(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORMS 1; 2; 3 AND 4), FUNCTION, ALTERNATIVE SPLICING, TISSUE SPECIFICITY, VARIANTS THR-53 AND SER-165.
      Tissue: Spleen.
    4. "A neuronal beta subunit (KCNMB4) makes the large conductance, voltage- and Ca2+-activated K+ channel resistant to charybdotoxin and iberiotoxin."
      Meera P., Wallner M., Toro L.
      Proc. Natl. Acad. Sci. U.S.A. 97:5562-5567(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT THR-53, GLYCOSYLATION.
    5. "hKCNMB3 and hKCNMB4, cloning and characterization of two members of the large-conductance calcium-activated potassium channel beta subunit family."
      Behrens R., Nolting A., Reimann F., Schwarz M., Waldschuetz R., Pongs O.
      FEBS Lett. 474:99-106(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4), VARIANT THR-53.
    6. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5).
      Tissue: Uterus.
    7. "The DNA sequence, annotation and analysis of human chromosome 3."
      Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
      , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
      Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    8. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    9. "Rectification and rapid activation at low Ca2+ of Ca2+-activated, voltage-dependent BK currents: consequences of rapid inactivation by a novel beta subunit."
      Xia X.-M., Ding J.-P., Zeng X.-H., Duan K.-L., Lingle C.J.
      J. Neurosci. 20:4890-4903(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    10. "Inactivation of BK channels mediated by the NH(2) terminus of the beta3b auxiliary subunit involves a two-step mechanism: possible separation of binding and blockade."
      Lingle C.J., Zeng X.-H., Ding J.-P., Xia X.-M.
      J. Gen. Physiol. 117:583-606(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: DOMAIN.
    11. "Gating properties conferred on BK channels by the beta3b auxiliary subunit in the absence of its NH(2)- and COOH termini."
      Zeng X.-H., Ding J.-P., Xia X.-M., Lingle C.J.
      J. Gen. Physiol. 117:607-628(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: DOMAIN.
    12. "Variants of the KCNMB3 regulatory subunit of maxi BK channels affect channel inactivation."
      Hu S., Labuda M.Z., Pandolfo M., Goss G.G., McDermid H.E., Ali D.W.
      Physiol. Genomics 15:191-198(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANTS VAL-75; SER-165 AND THR-230.
    13. "Redox-sensitive extracellular gates formed by auxiliary beta subunits of calcium-activated potassium channels."
      Zeng X.-H., Xia X.-M., Lingle C.J.
      Nat. Struct. Biol. 10:448-454(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: DISULFIDE BONDS, DOMAIN.
    14. "New disguises for an old channel: MaxiK channel beta-subunits."
      Orio P., Rojas P., Ferreira G., Latorre R.
      News Physiol. Sci. 17:156-161(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: REVIEW.

    Entry informationi

    Entry nameiKCMB3_HUMAN
    AccessioniPrimary (citable) accession number: Q9NPA1
    Secondary accession number(s): B7Z9C9
    , D3DNR2, E9PER5, Q9NPG7, Q9NRM9, Q9UHN3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 13, 2004
    Last sequence update: March 7, 2006
    Last modified: October 1, 2014
    This is version 113 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 3
      Human chromosome 3: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3