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Q9NPA1

- KCMB3_HUMAN

UniProt

Q9NPA1 - KCMB3_HUMAN

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Protein

Calcium-activated potassium channel subunit beta-3

Gene

KCNMB3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Alters the functional properties of the current expressed by the KCNMA1 channel. Isoform 2, isoform 3 and isoform 4 partially inactivate the current of KCNBMA. Isoform 4 induces a fast and incomplete inactivation of KCNMA1 channel that is detectable only at large depolarizations. In contrast, isoform 1 does not induce detectable inactivation of KCNMA1. Two or more subunits of KCNMB3 are required to block the KCNMA1 tetramer.2 Publications

GO - Molecular functioni

  1. calcium-activated potassium channel activity Source: UniProtKB
  2. potassium channel regulator activity Source: UniProtKB

GO - Biological processi

  1. action potential Source: UniProtKB
  2. blood coagulation Source: Reactome
  3. detection of calcium ion Source: UniProtKB
  4. neuronal action potential Source: UniProtKB
  5. potassium ion transmembrane transport Source: GOC
  6. potassium ion transport Source: UniProtKB
  7. synaptic transmission Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Ion channel

Keywords - Biological processi

Ion transport, Transport

Enzyme and pathway databases

ReactomeiREACT_23767. cGMP effects.
REACT_75896. Ca2+ activated K+ channels.

Protein family/group databases

TCDBi8.A.14.1.4. the ca(2+)-activated k(+) channel auxiliary subunit slowpoke- (slo) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Calcium-activated potassium channel subunit beta-3
Alternative name(s):
BK channel subunit beta-3
Short name:
BKbeta3
Short name:
Hbeta3
Calcium-activated potassium channel, subfamily M subunit beta-3
Charybdotoxin receptor subunit beta-3
K(VCA)beta-3
Maxi K channel subunit beta-3
Slo-beta-3
Gene namesi
Name:KCNMB3
Synonyms:KCNMB2, KCNMBL
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 3

Organism-specific databases

HGNCiHGNC:6287. KCNMB3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 6060CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei61 – 8121Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini82 – 207126ExtracellularSequence AnalysisAdd
BLAST
Transmembranei208 – 22821Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini229 – 27951CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of plasma membrane Source: UniProtKB
  2. plasma membrane Source: Reactome
  3. voltage-gated potassium channel complex Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA30067.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 279279Calcium-activated potassium channel subunit beta-3PRO_0000187054Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi131 – 1311N-linked (GlcNAc...)Sequence Analysis

Post-translational modificationi

N-glycosylated.1 Publication
The extracellular domain contains disulfide bond essential for the gating mechanism.

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9NPA1.
PRIDEiQ9NPA1.

Expressioni

Tissue specificityi

Isoform 1, isoform 3 and isoform 4 are widely expressed. Isoform 2 is expressed placenta, pancreas, kidney and heart. Isoform 1 and isoform 3 are highly expressed in pancreas and testis.3 Publications

Gene expression databases

BgeeiQ9NPA1.
CleanExiHS_KCNMB2.
HS_KCNMB3.
GenevestigatoriQ9NPA1.

Organism-specific databases

HPAiHPA015665.
HPA019185.

Interactioni

Subunit structurei

Interacts with KCNMA1 tetramer. There are probably 4 molecules of KCMNB3 per KCNMA1 tetramer.1 Publication

Protein-protein interaction databases

STRINGi9606.ENSP00000319370.

Structurei

3D structure databases

ProteinModelPortaliQ9NPA1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

Isoform 4 cytoplasmic N-terminal domain participates in the partial inactivation of KCNMA1, possibly by binding to a receptor site.
The extracellular domain forms gates to block ion permeation, providing a mechanism by which current can be rapidly diminished upon cellular repolarization.

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG29303.
GeneTreeiENSGT00390000015997.
HOGENOMiHOG000290180.
HOVERGENiHBG108059.
InParanoidiQ9NPA1.
KOiK04939.
OMAiNEEPNEL.
OrthoDBiEOG77WWDC.
PhylomeDBiQ9NPA1.
TreeFamiTF328589.

Family and domain databases

InterProiIPR003930. K_chnl_Ca-activ_BK_bsu.
[Graphical view]
PANTHERiPTHR10258. PTHR10258. 1 hit.
PfamiPF03185. CaKB. 1 hit.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9NPA1-1) [UniParc]FASTAAdd to Basket

Also known as: 3d

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDFSPSSELG FHFVAFILLT RHRTAFPASG KKRETDYSDG DPLDVHKRLP
60 70 80 90 100
SSAGEDRAVM LGFAMMGFSV LMFFLLGTTI LKPFMLSIQR EESTCTAIHT
110 120 130 140 150
DIMDDWLDCA FTCGVHCHGQ GKYPCLQVFV NLSHPGQKAL LHYNEEAVQI
160 170 180 190 200
NPKCFYTPKC HQDRNDLLNS ALDIKEFFDH KNGTPFSCFY SPASQSEDVI
210 220 230 240 250
LIKKYDQMAI FHCLFWPSLT LLGGALIVGM VRLTQHLSLL CEKYSTVVRD
260 270
EVGGKVPYIE QHQFKLCIMR RSKGRAEKS
Length:279
Mass (Da):31,604
Last modified:March 7, 2006 - v2
Checksum:iEC5F0D5D3E040C4C
GO
Isoform 2 (identifier: Q9NPA1-2) [UniParc]FASTAAdd to Basket

Also known as: 3a

The sequence of this isoform differs from the canonical sequence as follows:
     1-22: MDFSPSSELGFHFVAFILLTRH → MQPFSIPVQITLQGSRRRQG

Show »
Length:277
Mass (Da):31,351
Checksum:iEBF06FF8686F0655
GO
Isoform 3 (identifier: Q9NPA1-3) [UniParc]FASTAAdd to Basket

Also known as: 3c

The sequence of this isoform differs from the canonical sequence as follows:
     1-22: MDFSPSSELGFHFVAFILLTRH → MFPLLYELTAVSPSPFPQ

Show »
Length:275
Mass (Da):31,089
Checksum:i9C7C5A523D37D5C2
GO
Isoform 4 (identifier: Q9NPA1-4) [UniParc]FASTAAdd to Basket

Also known as: 3b

The sequence of this isoform differs from the canonical sequence as follows:
     1-22: Missing.
     23-23: R → M

Show »
Length:257
Mass (Da):29,045
Checksum:i0B5D59CB0551295D
GO
Isoform 5 (identifier: Q9NPA1-5) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-22: MDFSPSSELGFHFVAFILLTRH → MQPFSIPVQITLQGSRRRQG
     154-175: CFYTPKCHQDRNDLLNSALDIK → RDVTDCRVKEKQTLTVSDEHKQ
     176-279: Missing.

Note: No experimental confirmation available.

Show »
Length:173
Mass (Da):19,474
Checksum:i7EACEF7D7202F1B8
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti24 – 241T → P in BAH14265. (PubMed:14702039)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti44 – 441D → G.
Corresponds to variant rs1170672 [ dbSNP | Ensembl ].
VAR_018173
Natural varianti53 – 531A → T.5 Publications
Corresponds to variant rs7645550 [ dbSNP | Ensembl ].
VAR_018174
Natural varianti75 – 751L → V.1 Publication
Corresponds to variant rs2276802 [ dbSNP | Ensembl ].
VAR_018175
Natural varianti165 – 1651N → S.2 Publications
Corresponds to variant rs139527128 [ dbSNP | Ensembl ].
VAR_018176
Natural varianti230 – 2301M → T.1 Publication
VAR_018177

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 2222MDFSP…LLTRH → MQPFSIPVQITLQGSRRRQG in isoform 2 and isoform 5. 1 PublicationVSP_009827Add
BLAST
Alternative sequencei1 – 2222MDFSP…LLTRH → MFPLLYELTAVSPSPFPQ in isoform 3. 1 PublicationVSP_009828Add
BLAST
Alternative sequencei1 – 2222Missing in isoform 4. 2 PublicationsVSP_009829Add
BLAST
Alternative sequencei23 – 231R → M in isoform 4. 2 PublicationsVSP_009830
Alternative sequencei154 – 17522CFYTP…ALDIK → RDVTDCRVKEKQTLTVSDEH KQ in isoform 5. 1 PublicationVSP_046090Add
BLAST
Alternative sequencei176 – 279104Missing in isoform 5. 1 PublicationVSP_046091Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF139471 mRNA. Translation: AAD54771.1.
AF214561 mRNA. Translation: AAF36598.1.
AF204159 Genomic DNA. Translation: AAF97031.1.
AF204160 Genomic DNA. Translation: AAF97032.1.
AF204161 Genomic DNA. Translation: AAF97033.1.
AF204162 Genomic DNA. Translation: AAF97034.1.
AF160968 mRNA. Translation: AAF67811.1.
AF170916 mRNA. Translation: AAF89698.1.
AK304837 mRNA. Translation: BAH14265.1.
AC007823 Genomic DNA. No translation available.
AC076966 Genomic DNA. No translation available.
CH471052 Genomic DNA. Translation: EAW78418.1.
CH471052 Genomic DNA. Translation: EAW78421.1.
CCDSiCCDS3225.1. [Q9NPA1-2]
CCDS3226.1. [Q9NPA1-1]
CCDS43172.1. [Q9NPA1-4]
CCDS43173.1. [Q9NPA1-3]
CCDS54683.1. [Q9NPA1-5]
RefSeqiNP_001157149.1. NM_001163677.1. [Q9NPA1-5]
NP_055222.3. NM_014407.3. [Q9NPA1-1]
NP_741979.1. NM_171828.2. [Q9NPA1-2]
NP_741980.1. NM_171829.2. [Q9NPA1-4]
NP_741981.1. NM_171830.1. [Q9NPA1-3]
UniGeneiHs.591285.

Genome annotation databases

EnsembliENST00000314235; ENSP00000319370; ENSG00000171121. [Q9NPA1-1]
ENST00000349697; ENSP00000327866; ENSG00000171121. [Q9NPA1-2]
ENST00000392685; ENSP00000376451; ENSG00000171121. [Q9NPA1-3]
ENST00000392686; ENSP00000376452; ENSG00000171121. [Q9NPA1-4]
ENST00000485523; ENSP00000418536; ENSG00000171121. [Q9NPA1-4]
ENST00000497599; ENSP00000417091; ENSG00000171121. [Q9NPA1-5]
GeneIDi27094.
KEGGihsa:27094.
UCSCiuc003fjm.3. human. [Q9NPA1-1]
uc003fjn.3. human. [Q9NPA1-3]
uc003fjo.3. human. [Q9NPA1-4]
uc003fjp.1. human. [Q9NPA1-2]

Polymorphism databases

DMDMi90111824.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF139471 mRNA. Translation: AAD54771.1 .
AF214561 mRNA. Translation: AAF36598.1 .
AF204159 Genomic DNA. Translation: AAF97031.1 .
AF204160 Genomic DNA. Translation: AAF97032.1 .
AF204161 Genomic DNA. Translation: AAF97033.1 .
AF204162 Genomic DNA. Translation: AAF97034.1 .
AF160968 mRNA. Translation: AAF67811.1 .
AF170916 mRNA. Translation: AAF89698.1 .
AK304837 mRNA. Translation: BAH14265.1 .
AC007823 Genomic DNA. No translation available.
AC076966 Genomic DNA. No translation available.
CH471052 Genomic DNA. Translation: EAW78418.1 .
CH471052 Genomic DNA. Translation: EAW78421.1 .
CCDSi CCDS3225.1. [Q9NPA1-2 ]
CCDS3226.1. [Q9NPA1-1 ]
CCDS43172.1. [Q9NPA1-4 ]
CCDS43173.1. [Q9NPA1-3 ]
CCDS54683.1. [Q9NPA1-5 ]
RefSeqi NP_001157149.1. NM_001163677.1. [Q9NPA1-5 ]
NP_055222.3. NM_014407.3. [Q9NPA1-1 ]
NP_741979.1. NM_171828.2. [Q9NPA1-2 ]
NP_741980.1. NM_171829.2. [Q9NPA1-4 ]
NP_741981.1. NM_171830.1. [Q9NPA1-3 ]
UniGenei Hs.591285.

3D structure databases

ProteinModelPortali Q9NPA1.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000319370.

Chemistry

DrugBanki DB01110. Miconazole.
DB00721. Procaine.

Protein family/group databases

TCDBi 8.A.14.1.4. the ca(2+)-activated k(+) channel auxiliary subunit slowpoke- (slo) family.

Polymorphism databases

DMDMi 90111824.

Proteomic databases

PaxDbi Q9NPA1.
PRIDEi Q9NPA1.

Protocols and materials databases

DNASUi 27094.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000314235 ; ENSP00000319370 ; ENSG00000171121 . [Q9NPA1-1 ]
ENST00000349697 ; ENSP00000327866 ; ENSG00000171121 . [Q9NPA1-2 ]
ENST00000392685 ; ENSP00000376451 ; ENSG00000171121 . [Q9NPA1-3 ]
ENST00000392686 ; ENSP00000376452 ; ENSG00000171121 . [Q9NPA1-4 ]
ENST00000485523 ; ENSP00000418536 ; ENSG00000171121 . [Q9NPA1-4 ]
ENST00000497599 ; ENSP00000417091 ; ENSG00000171121 . [Q9NPA1-5 ]
GeneIDi 27094.
KEGGi hsa:27094.
UCSCi uc003fjm.3. human. [Q9NPA1-1 ]
uc003fjn.3. human. [Q9NPA1-3 ]
uc003fjo.3. human. [Q9NPA1-4 ]
uc003fjp.1. human. [Q9NPA1-2 ]

Organism-specific databases

CTDi 27094.
GeneCardsi GC03M178957.
HGNCi HGNC:6287. KCNMB3.
HPAi HPA015665.
HPA019185.
MIMi 605222. gene.
neXtProti NX_Q9NPA1.
PharmGKBi PA30067.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG29303.
GeneTreei ENSGT00390000015997.
HOGENOMi HOG000290180.
HOVERGENi HBG108059.
InParanoidi Q9NPA1.
KOi K04939.
OMAi NEEPNEL.
OrthoDBi EOG77WWDC.
PhylomeDBi Q9NPA1.
TreeFami TF328589.

Enzyme and pathway databases

Reactomei REACT_23767. cGMP effects.
REACT_75896. Ca2+ activated K+ channels.

Miscellaneous databases

GeneWikii KCNMB3.
GenomeRNAii 27094.
NextBioi 49727.
PROi Q9NPA1.
SOURCEi Search...

Gene expression databases

Bgeei Q9NPA1.
CleanExi HS_KCNMB2.
HS_KCNMB3.
Genevestigatori Q9NPA1.

Family and domain databases

InterProi IPR003930. K_chnl_Ca-activ_BK_bsu.
[Graphical view ]
PANTHERi PTHR10258. PTHR10258. 1 hit.
Pfami PF03185. CaKB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of a putative regulatory subunit of a calcium-activated potassium channel in the dup(3q) syndrome region and a related sequence on 22q11.2."
    Riazi M.A., Brinkman-Mills P., Johnson A., Naylor S.L., Minoshima S., Shimizu N., Baldini A., McDermid H.E.
    Genomics 62:90-94(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3), VARIANT THR-53, TISSUE SPECIFICITY.
  2. "Cloning and functional characterization of novel large conductance calcium-activated potassium channel beta subunits, hKCNMB3 and hKCNMB4."
    Brenner R., Jegla T.J., Wickenden A., Liu Y., Aldrich R.W.
    J. Biol. Chem. 275:6453-6461(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4), VARIANT THR-53, TISSUE SPECIFICITY, INTERACTION WITH KCNMA1.
    Tissue: Brain.
  3. "Cloning and functional expression of two families of Beta-subunits of the large conductance calcium-activated potassium channel."
    Uebele V.N., Lagrutta A.A., Wade T., Figueroa D.J., Liu Y., McKenna E., Austin C.P., Bennett P.B., Swanson R.
    J. Biol. Chem. 275:23211-23218(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORMS 1; 2; 3 AND 4), FUNCTION, ALTERNATIVE SPLICING, TISSUE SPECIFICITY, VARIANTS THR-53 AND SER-165.
    Tissue: Spleen.
  4. "A neuronal beta subunit (KCNMB4) makes the large conductance, voltage- and Ca2+-activated K+ channel resistant to charybdotoxin and iberiotoxin."
    Meera P., Wallner M., Toro L.
    Proc. Natl. Acad. Sci. U.S.A. 97:5562-5567(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT THR-53, GLYCOSYLATION.
  5. "hKCNMB3 and hKCNMB4, cloning and characterization of two members of the large-conductance calcium-activated potassium channel beta subunit family."
    Behrens R., Nolting A., Reimann F., Schwarz M., Waldschuetz R., Pongs O.
    FEBS Lett. 474:99-106(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4), VARIANT THR-53.
  6. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5).
    Tissue: Uterus.
  7. "The DNA sequence, annotation and analysis of human chromosome 3."
    Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
    , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
    Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  8. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  9. "Rectification and rapid activation at low Ca2+ of Ca2+-activated, voltage-dependent BK currents: consequences of rapid inactivation by a novel beta subunit."
    Xia X.-M., Ding J.-P., Zeng X.-H., Duan K.-L., Lingle C.J.
    J. Neurosci. 20:4890-4903(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  10. "Inactivation of BK channels mediated by the NH(2) terminus of the beta3b auxiliary subunit involves a two-step mechanism: possible separation of binding and blockade."
    Lingle C.J., Zeng X.-H., Ding J.-P., Xia X.-M.
    J. Gen. Physiol. 117:583-606(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: DOMAIN.
  11. "Gating properties conferred on BK channels by the beta3b auxiliary subunit in the absence of its NH(2)- and COOH termini."
    Zeng X.-H., Ding J.-P., Xia X.-M., Lingle C.J.
    J. Gen. Physiol. 117:607-628(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: DOMAIN.
  12. "Variants of the KCNMB3 regulatory subunit of maxi BK channels affect channel inactivation."
    Hu S., Labuda M.Z., Pandolfo M., Goss G.G., McDermid H.E., Ali D.W.
    Physiol. Genomics 15:191-198(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS VAL-75; SER-165 AND THR-230.
  13. "Redox-sensitive extracellular gates formed by auxiliary beta subunits of calcium-activated potassium channels."
    Zeng X.-H., Xia X.-M., Lingle C.J.
    Nat. Struct. Biol. 10:448-454(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: DISULFIDE BONDS, DOMAIN.
  14. "New disguises for an old channel: MaxiK channel beta-subunits."
    Orio P., Rojas P., Ferreira G., Latorre R.
    News Physiol. Sci. 17:156-161(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.

Entry informationi

Entry nameiKCMB3_HUMAN
AccessioniPrimary (citable) accession number: Q9NPA1
Secondary accession number(s): B7Z9C9
, D3DNR2, E9PER5, Q9NPG7, Q9NRM9, Q9UHN3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: March 7, 2006
Last modified: October 29, 2014
This is version 114 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3