Q9NPA1 (KCMB3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Calcium-activated potassium channel subunit beta-3

Alternative name(s):
BK channel subunit beta-3
Short name=BKbeta3
Short name=Hbeta3
Calcium-activated potassium channel, subfamily M subunit beta-3
Charybdotoxin receptor subunit beta-3
K(VCA)beta-3
Maxi K channel subunit beta-3
Slo-beta-3

Gene names

Name:	KCNMB3
Synonyms:	KCNMB2, KCNMBL

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	279 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Alters the functional properties of the current expressed by the KCNMA1 channel. Isoform 2, isoform 3 and isoform 4 partially inactivate the current of KCNBMA. Isoform 4 induces a fast and incomplete inactivation of KCNMA1 channel that is detectable only at large depolarizations. In contrast, isoform 1 does not induce detectable inactivation of KCNMA1. Two or more subunits of KCNMB3 are required to block the KCNMA1 tetramer. Ref.3 Ref.9
Subunit structure	Interacts with KCNMA1 tetramer. There are probably 4 molecules of KCMNB3 per KCNMA1 tetramer. Ref.2
Subcellular location	Membrane; Multi-pass membrane protein.
Tissue specificity	Isoform 1, isoform 3 and isoform 4 are widely expressed. Isoform 2 is expressed placenta, pancreas, kidney and heart. Isoform 1 and isoform 3 are highly expressed in pancreas and testis. Ref.1 Ref.2 Ref.3
Domain	Isoform 4 cytoplasmic N-terminus domain participates in the partial inactivation of KCNMA1, possibly by binding to a receptor site. Ref.10 Ref.11 Ref.13 The extracellular domain forms gates to block ion permeation, providing a mechanism by which current can be rapidly diminished upon cellular repolarization. Ref.10 Ref.11 Ref.13
Post-translational modification	N-glycosylated. Ref.4 The extracellular domain contains disulfide bond essential for the gating mechanism.
Sequence similarities	Belongs to the KCNMB (TC 8.A.14.1) family. KCNMB3 subfamily. [View classification]

Ontologies

Keywords
Biological process	Ion transport Transport
Cellular component	Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Transmembrane Transmembrane helix
Molecular function	Ion channel
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	blood coagulation Traceable author statement. Source: Reactome detection of calcium ion Inferred from direct assay Ref.2. Source: UniProtKB regulation of action potential in neuron Inferred from direct assay Ref.2. Source: UniProtKB synaptic transmission Traceable author statement. Source: Reactome
Cellular_component	voltage-gated potassium channel complex Inferred from direct assay Ref.2. Source: UniProtKB
Molecular_function	calcium-activated potassium channel activity Inferred from direct assay Ref.2. Source: UniProtKB potassium channel regulator activity Non-traceable author statement Ref.3Ref.4. Source: UniProtKB
Complete GO annotation...

Alternative products

This entry describes 5 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9NPA1-1)

Also known as: 3d;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9NPA1-2)

Also known as: 3a;

The sequence of this isoform differs from the canonical sequence as follows:
     1-22: MDFSPSSELGFHFVAFILLTRH → MQPFSIPVQITLQGSRRRQG

Isoform 3 (identifier: Q9NPA1-3)

Also known as: 3c;

The sequence of this isoform differs from the canonical sequence as follows:
     1-22: MDFSPSSELGFHFVAFILLTRH → MFPLLYELTAVSPSPFPQ

Isoform 4 (identifier: Q9NPA1-4)

Also known as: 3b;

The sequence of this isoform differs from the canonical sequence as follows:
     1-22: Missing.
     23-23: R → M

Isoform 5 (identifier: Q9NPA1-5)

The sequence of this isoform differs from the canonical sequence as follows:
     1-22: MDFSPSSELGFHFVAFILLTRH → MQPFSIPVQITLQGSRRRQG
     154-175: CFYTPKCHQDRNDLLNSALDIK → RDVTDCRVKEKQTLTVSDEHKQ
     176-279: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 279	279	Calcium-activated potassium channel subunit beta-3		PRO_0000187054
Regions
	Topological domain	1 – 60	60	Cytoplasmic Potential
	Transmembrane	61 – 81	21	Helical; Name=1; Potential
	Topological domain	82 – 207	126	Extracellular Potential
	Transmembrane	208 – 228	21	Helical; Name=2; Potential
	Topological domain	229 – 279	51	Cytoplasmic Potential
Amino acid modifications
	Glycosylation	131	1	N-linked (GlcNAc...) Potential
Natural variations
	Alternative sequence	1 – 22	22	MDFSP…LLTRH → MQPFSIPVQITLQGSRRRQG in isoform 2 and isoform 5.		VSP_009827
	Alternative sequence	1 – 22	22	MDFSP…LLTRH → MFPLLYELTAVSPSPFPQ in isoform 3.		VSP_009828
	Alternative sequence	1 – 22	22	Missing in isoform 4.		VSP_009829
	Alternative sequence	23	1	R → M in isoform 4.		VSP_009830
	Alternative sequence	154 – 175	22	CFYTP…ALDIK → RDVTDCRVKEKQTLTVSDEH KQ in isoform 5.		VSP_046090
	Alternative sequence	176 – 279	104	Missing in isoform 5.		VSP_046091
	Natural variant	44	1	D → G. Corresponds to variant rs1170672 [ dbSNP | Ensembl ].		VAR_018173
	Natural variant	53	1	A → T. Ref.1 Ref.2 Ref.3 Ref.4 Ref.5 Corresponds to variant rs7645550 [ dbSNP | Ensembl ].		VAR_018174
	Natural variant	75	1	L → V. Ref.12 Corresponds to variant rs2276802 [ dbSNP | Ensembl ].		VAR_018175
	Natural variant	165	1	N → S. Ref.3 Ref.12		VAR_018176
	Natural variant	230	1	M → T. Ref.12		VAR_018177
Experimental info
	Sequence conflict	24	1	T → P in BAH14265. Ref.6

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 (3d) [UniParc]. Last modified March 7, 2006. Version 2. Checksum: EC5F0D5D3E040C4C	FASTA	279	31,604
	10 20 30 40 50 60 MDFSPSSELG FHFVAFILLT RHRTAFPASG KKRETDYSDG DPLDVHKRLP SSAGEDRAVM 70 80 90 100 110 120 LGFAMMGFSV LMFFLLGTTI LKPFMLSIQR EESTCTAIHT DIMDDWLDCA FTCGVHCHGQ 130 140 150 160 170 180 GKYPCLQVFV NLSHPGQKAL LHYNEEAVQI NPKCFYTPKC HQDRNDLLNS ALDIKEFFDH 190 200 210 220 230 240 KNGTPFSCFY SPASQSEDVI LIKKYDQMAI FHCLFWPSLT LLGGALIVGM VRLTQHLSLL 250 260 270 CEKYSTVVRD EVGGKVPYIE QHQFKLCIMR RSKGRAEKS
	Isoform 2 (3a) [UniParc]. Checksum: EBF06FF8686F0655	FASTA	277	31,351
	10 20 30 40 50 60 MQPFSIPVQI TLQGSRRRQG RTAFPASGKK RETDYSDGDP LDVHKRLPSS AGEDRAVMLG 70 80 90 100 110 120 FAMMGFSVLM FFLLGTTILK PFMLSIQREE STCTAIHTDI MDDWLDCAFT CGVHCHGQGK 130 140 150 160 170 180 YPCLQVFVNL SHPGQKALLH YNEEAVQINP KCFYTPKCHQ DRNDLLNSAL DIKEFFDHKN 190 200 210 220 230 240 GTPFSCFYSP ASQSEDVILI KKYDQMAIFH CLFWPSLTLL GGALIVGMVR LTQHLSLLCE 250 260 270 KYSTVVRDEV GGKVPYIEQH QFKLCIMRRS KGRAEKS
	Isoform 3 (3c) [UniParc]. Checksum: 9C7C5A523D37D5C2	FASTA	275	31,089
	10 20 30 40 50 60 MFPLLYELTA VSPSPFPQRT AFPASGKKRE TDYSDGDPLD VHKRLPSSAG EDRAVMLGFA 70 80 90 100 110 120 MMGFSVLMFF LLGTTILKPF MLSIQREEST CTAIHTDIMD DWLDCAFTCG VHCHGQGKYP 130 140 150 160 170 180 CLQVFVNLSH PGQKALLHYN EEAVQINPKC FYTPKCHQDR NDLLNSALDI KEFFDHKNGT 190 200 210 220 230 240 PFSCFYSPAS QSEDVILIKK YDQMAIFHCL FWPSLTLLGG ALIVGMVRLT QHLSLLCEKY 250 260 270 STVVRDEVGG KVPYIEQHQF KLCIMRRSKG RAEKS
	Isoform 4 (3b) [UniParc]. Checksum: 0B5D59CB0551295D	FASTA	257	29,045
	10 20 30 40 50 60 MTAFPASGKK RETDYSDGDP LDVHKRLPSS AGEDRAVMLG FAMMGFSVLM FFLLGTTILK 70 80 90 100 110 120 PFMLSIQREE STCTAIHTDI MDDWLDCAFT CGVHCHGQGK YPCLQVFVNL SHPGQKALLH 130 140 150 160 170 180 YNEEAVQINP KCFYTPKCHQ DRNDLLNSAL DIKEFFDHKN GTPFSCFYSP ASQSEDVILI 190 200 210 220 230 240 KKYDQMAIFH CLFWPSLTLL GGALIVGMVR LTQHLSLLCE KYSTVVRDEV GGKVPYIEQH 250 QFKLCIMRRS KGRAEKS
	Isoform 5 [UniParc]. Checksum: 7EACEF7D7202F1B8	FASTA	173	19,474
	10 20 30 40 50 60 MQPFSIPVQI TLQGSRRRQG RTAFPASGKK RETDYSDGDP LDVHKRLPSS AGEDRAVMLG 70 80 90 100 110 120 FAMMGFSVLM FFLLGTTILK PFMLSIQREE STCTAIHTDI MDDWLDCAFT CGVHCHGQGK 130 140 150 160 170 YPCLQVFVNL SHPGQKALLH YNEEAVQINP KRDVTDCRVK EKQTLTVSDE HKQ

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification of a putative regulatory subunit of a calcium-activated potassium channel in the dup(3q) syndrome region and a related sequence on 22q11.2." Riazi M.A., Brinkman-Mills P., Johnson A., Naylor S.L., Minoshima S., Shimizu N., Baldini A., McDermid H.E. Genomics 62:90-94(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3), VARIANT THR-53, TISSUE SPECIFICITY.
[2]	"Cloning and functional characterization of novel large conductance calcium-activated potassium channel beta subunits, hKCNMB3 and hKCNMB4." Brenner R., Jegla T.J., Wickenden A., Liu Y., Aldrich R.W. J. Biol. Chem. 275:6453-6461(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4), VARIANT THR-53, TISSUE SPECIFICITY, INTERACTION WITH KCNMA1. Tissue: Brain.
[3]	"Cloning and functional expression of two families of Beta-subunits of the large conductance calcium-activated potassium channel." Uebele V.N., Lagrutta A.A., Wade T., Figueroa D.J., Liu Y., McKenna E., Austin C.P., Bennett P.B., Swanson R. J. Biol. Chem. 275:23211-23218(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORMS 1; 2; 3 AND 4), FUNCTION, ALTERNATIVE SPLICING, TISSUE SPECIFICITY, VARIANTS THR-53 AND SER-165. Tissue: Spleen.
[4]	"A neuronal beta subunit (KCNMB4) makes the large conductance, voltage- and Ca2+-activated K+ channel resistant to charybdotoxin and iberiotoxin." Meera P., Wallner M., Toro L. Proc. Natl. Acad. Sci. U.S.A. 97:5562-5567(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT THR-53, GLYCOSYLATION.
[5]	"hKCNMB3 and hKCNMB4, cloning and characterization of two members of the large-conductance calcium-activated potassium channel beta subunit family." Behrens R., Nolting A., Reimann F., Schwarz M., Waldschuetz R., Pongs O. FEBS Lett. 474:99-106(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4), VARIANT THR-53.
[6]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5). Tissue: Uterus.
[7]	"The DNA sequence, annotation and analysis of human chromosome 3." Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J. , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A. Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[8]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[9]	"Rectification and rapid activation at low Ca2+ of Ca2+-activated, voltage-dependent BK currents: consequences of rapid inactivation by a novel beta subunit." Xia X.-M., Ding J.-P., Zeng X.-H., Duan K.-L., Lingle C.J. J. Neurosci. 20:4890-4903(2000) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION.
[10]	"Inactivation of BK channels mediated by the NH(2) terminus of the beta3b auxiliary subunit involves a two-step mechanism: possible separation of binding and blockade." Lingle C.J., Zeng X.-H., Ding J.-P., Xia X.-M. J. Gen. Physiol. 117:583-606(2001) [PubMed] [Europe PMC] [Abstract] Cited for: DOMAIN.
[11]	"Gating properties conferred on BK channels by the beta3b auxiliary subunit in the absence of its NH(2)- and COOH termini." Zeng X.-H., Ding J.-P., Xia X.-M., Lingle C.J. J. Gen. Physiol. 117:607-628(2001) [PubMed] [Europe PMC] [Abstract] Cited for: DOMAIN.
[12]	"Variants of the KCNMB3 regulatory subunit of maxi BK channels affect channel inactivation." Hu S., Labuda M.Z., Pandolfo M., Goss G.G., McDermid H.E., Ali D.W. Physiol. Genomics 15:191-198(2003) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANTS VAL-75; SER-165 AND THR-230.
[13]	"Redox-sensitive extracellular gates formed by auxiliary beta subunits of calcium-activated potassium channels." Zeng X.-H., Xia X.-M., Lingle C.J. Nat. Struct. Biol. 10:448-454(2003) [PubMed] [Europe PMC] [Abstract] Cited for: DISULFIDE BONDS, DOMAIN.
[14]	"New disguises for an old channel: MaxiK channel beta-subunits." Orio P., Rojas P., Ferreira G., Latorre R. News Physiol. Sci. 17:156-161(2002) [PubMed] [Europe PMC] [Abstract] Cited for: REVIEW.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF139471 mRNA. Translation: AAD54771.1. AF214561 mRNA. Translation: AAF36598.1. AF204159 Genomic DNA. Translation: AAF97031.1. AF204160 Genomic DNA. Translation: AAF97032.1. AF204161 Genomic DNA. Translation: AAF97033.1. AF204162 Genomic DNA. Translation: AAF97034.1. AF160968 mRNA. Translation: AAF67811.1. AF170916 mRNA. Translation: AAF89698.1. AK304837 mRNA. Translation: BAH14265.1. AC007823 Genomic DNA. No translation available. AC076966 Genomic DNA. No translation available. CH471052 Genomic DNA. Translation: EAW78418.1. CH471052 Genomic DNA. Translation: EAW78421.1.
IPI	IPI00249414. IPI00296154. IPI00299315. IPI00299880. IPI00922327.
RefSeq	NP_001157149.1. NM_001163677.1. NP_055222.3. NM_014407.3. NP_741979.1. NM_171828.1. NP_741980.1. NM_171829.2. NP_741981.1. NM_171830.1.
UniGene	Hs.591285.
3D structure databases
ProteinModelPortal	Q9NPA1.
SMR	Q9NPA1. Positions 16-56.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000319370.
Protein family/group databases
TCDB	8.A.14.1.4. Ca2+-activated K+ channel auxiliary subunit slowpoke-beta (Slobeta) family.
Polymorphism databases
DMDM	90111824.
Proteomic databases
PaxDb	Q9NPA1.
PRIDE	Q9NPA1.
Protocols and materials databases
DNASU	27094.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000314235; ENSP00000319370; ENSG00000171121. ENST00000349697; ENSP00000327866; ENSG00000171121. ENST00000392685; ENSP00000376451; ENSG00000171121. ENST00000392686; ENSP00000376452; ENSG00000171121. ENST00000485523; ENSP00000418536; ENSG00000171121. ENST00000497599; ENSP00000417091; ENSG00000171121.
GeneID	27094.
KEGG	hsa:27094.
UCSC	uc003fjm.3. human. uc003fjn.3. human. uc003fjo.3. human. uc003fjp.1. human.
Organism-specific databases
CTD	27094.
GeneCards	GC03M178957.
HGNC	HGNC:6287. KCNMB3.
HPA	HPA015665. HPA019185.
MIM	605222. gene.
neXtProt	NX_Q9NPA1.
PharmGKB	PA30067.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG29303.
HOGENOM	HOG000290180.
HOVERGEN	HBG108059.
InParanoid	Q9NPA1.
KO	K04939.
OMA	KPFMLST.
PhylomeDB	Q9NPA1.
Enzyme and pathway databases
Reactome	REACT_13685. Neuronal System. REACT_604. Hemostasis.
Gene expression databases
ArrayExpress	Q9NPA1.
Bgee	Q9NPA1.
CleanEx	HS_KCNMB2. HS_KCNMB3.
Genevestigator	Q9NPA1.
GermOnline	ENSG00000171121. Homo sapiens.
Family and domain databases
InterPro	IPR003930. K_chnl_Ca-activ_BK_bsu. [Graphical view]
PANTHER	PTHR10258. PTHR10258. 1 hit.
Pfam	PF03185. CaKB. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChEMBL	CHEMBL3934.
GenomeRNAi	27094.
NextBio	49727.
SOURCE	Search...

Entry information

Entry name

KCMB3_HUMAN

Accession

Primary (citable) accession number: Q9NPA1
Secondary accession number(s): B7Z9C9 , D3DNR2, E9PER5, Q9NPG7, Q9NRM9, Q9UHN3

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 13, 2004
Last sequence update:	March 7, 2006
Last modified:	May 1, 2013
This is version 99 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.