Q9NPA0 (EMC7_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
ER membrane protein complex subunit 7

Gene names

Name:	EMC7
Synonyms:	C11orf3, C15orf24
ORF Names:	HT022, UNQ905/PRO1926

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	242 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Subunit structure	Component of the ER membrane protein complex (EMC). Ref.8
Subcellular location	Membrane; Single-pass type I membrane protein Ref.8.
Sequence similarities	Belongs to the EMC7 family.
Caution	Has been termed C11orf3 (Ref.1), but is not the official C11orf3 as defined by HGNC and furthermore maps to chromosome 15.

Ontologies

Keywords
Cellular component	Membrane
Domain	Signal Transmembrane Transmembrane helix
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	ER membrane protein complex Inferred from direct assay Ref.8. Source: UniProtKB
Molecular_function	carbohydrate binding Inferred from electronic annotation. Source: InterPro purine nucleotide binding Non-traceable author statement Ref.1. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 23	23	Potential
	Chain	24 – 242	219	ER membrane protein complex subunit 7		PRO_0000240860
Regions
	Topological domain	24 – 159	136	Extracellular Potential
	Transmembrane	160 – 180	21	Helical; Potential
	Topological domain	181 – 242	62	Cytoplasmic Potential

Sequences

	Sequence		Length	Mass (Da)
	Q9NPA0 [UniParc]. Last modified October 1, 2000. Version 1. Checksum: A71930B89A4C2458	FASTA	242	26,471
	10 20 30 40 50 60 MAAALWGFFP VLLLLLLSGD VQSSEVPGAA AEGSGGSGVG IGDRFKIEGR AVVPGVKPQD 70 80 90 100 110 120 WISAARVLVD GEEHVGFLKT DGSFVVHDIP SGSYVVEVVS PAYRFDPVRV DITSKGKMRA 130 140 150 160 170 180 RYVNYIKTSE VVRLPYPLQM KSSGPPSYFI KRESWGWTDF LMNPMVMMMV LPLLIFVLLP 190 200 210 220 230 240 KVVNTSDPDM RREMEQSMNM LNSNHELPDV SEFMTRLFSS KSSGKSSSGS SKTGKSGAGK RR

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Characterization of five novel human genes in the 11q13-q22 region." O'Brien K.P., Tapia-Paez I., Staahle-Baeckdahl M., Kedra D., Dumanski J.P. Biochem. Biophys. Res. Commun. 273:90-94(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Full-length of some new muscular transcript." Ievolella C., Lanfranchi G. Submitted (AUG-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Muscle.
[3]	Xu X., Yang Y., Gao G., Xiao H., Chen Z., Han Z. Submitted (MAR-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Hypothalamus.
[4]	"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M. Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[5]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain cortex and Lung.
[7]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[8]	"Defining human ERAD networks through an integrative mapping strategy." Christianson J.C., Olzmann J.A., Shaler T.A., Sowa M.E., Bennett E.J., Richter C.M., Tyler R.E., Greenblatt E.J., Harper J.W., Kopito R.R. Nat. Cell Biol. 14:93-105(2012) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION IN THE EMC COMPLEX, SUBCELLULAR LOCATION.
[9]	"Single MHC mutation eliminates enthalpy associated with T cell receptor binding." Miller P.J., Pazy Y., Conti B., Riddle D., Appella E., Collins E.J. J. Mol. Biol. 373:315-327(2007) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) OF 4-12.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AJ250344 mRNA. Translation: CAB96539.1.
AJ245874 mRNA. Translation: CAC01611.1.
AF242729 mRNA. Translation: AAG44477.1.
AY358445 mRNA. Translation: AAQ88810.1.
AK314883 mRNA. Translation: BAG37397.1.
BC012456 mRNA. Translation: AAH12456.1.
BC104934 mRNA. Translation: AAI04935.1.
BC104936 mRNA. Translation: AAI04937.1.

IPI

IPI00024551.

RefSeq

NP_064539.1. NM_020154.2.

UniGene

Hs.160565.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2UWE	X-ray	2.40	C/J	4-12	[»]

ProteinModelPortal

Q9NPA0.

ModBase

Search...

Protein-protein interaction databases

IntAct

Q9NPA0. 1 interaction.

STRING

9606.ENSP00000256545.

PTM databases

PhosphoSite

Q9NPA0.

Polymorphism databases

DMDM

74752878.

Proteomic databases

PaxDb

Q9NPA0.

PRIDE

Q9NPA0.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000256545; ENSP00000256545; ENSG00000134153.

GeneID

56851.

KEGG

hsa:56851.

UCSC

uc001zhm.3. human.

Organism-specific databases

CTD

56851.

GeneCards

GC15M034377.

H-InvDB

HIX0012085.

HGNC

HGNC:24301. EMC7.

HPA

HPA010029.

neXtProt

NX_Q9NPA0.

PharmGKB

PA134900493.

GenAtlas

Search...

Phylogenomic databases

eggNOG

NOG81025.

HOGENOM

HOG000230739.

HOVERGEN

HBG058796.

InParanoid

Q9NPA0.

OMA

TANDPEL.

OrthoDB

EOG4J119B.

PhylomeDB

Q9NPA0.

Gene expression databases

ArrayExpress

Q9NPA0.

Bgee

Q9NPA0.

CleanEx

HS_C15orf24.

Genevestigator

Q9NPA0.

GermOnline

ENSG00000134153. Homo sapiens.

Family and domain databases

InterPro

IPR013784. Carb-bd-like_fold.
IPR019008. DUF2012.
[Graphical view]

Pfam

PF09430. DUF2012. 1 hit.
[Graphical view]

SUPFAM

SSF49452. CBD_4. 1 hit.

ProtoNet

Search...

Other

EvolutionaryTrace

Q9NPA0.

GenomeRNAi

56851.

NextBio

62258.

Entry information

Entry name

EMC7_HUMAN

Accession

Primary (citable) accession number: Q9NPA0
Secondary accession number(s): B2RC00, Q96ED5

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 27, 2006
Last sequence update:	October 1, 2000
Last modified:	April 3, 2013
This is version 89 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.