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Q9NPA0

- EMC7_HUMAN

UniProt

Q9NPA0 - EMC7_HUMAN

Protein

ER membrane protein complex subunit 7

Gene

EMC7

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 99 (01 Oct 2014)
      Sequence version 1 (01 Oct 2000)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. carbohydrate binding Source: InterPro
    2. purine nucleotide binding Source: UniProtKB

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    ER membrane protein complex subunit 7
    Gene namesi
    Name:EMC7
    Synonyms:C11orf3, C15orf24
    ORF Names:HT022, UNQ905/PRO1926
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 15

    Organism-specific databases

    HGNCiHGNC:24301. EMC7.

    Subcellular locationi

    Membrane 1 Publication; Single-pass type I membrane protein 1 Publication

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB
    2. ER membrane protein complex Source: UniProtKB
    3. integral component of membrane Source: UniProtKB

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134900493.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2323Sequence AnalysisAdd
    BLAST
    Chaini24 – 242219ER membrane protein complex subunit 7PRO_0000240860Add
    BLAST

    Proteomic databases

    MaxQBiQ9NPA0.
    PaxDbiQ9NPA0.
    PRIDEiQ9NPA0.

    PTM databases

    PhosphoSiteiQ9NPA0.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9NPA0.
    BgeeiQ9NPA0.
    CleanExiHS_C15orf24.
    GenevestigatoriQ9NPA0.

    Organism-specific databases

    HPAiHPA010029.

    Interactioni

    Subunit structurei

    Component of the ER membrane protein complex (EMC).1 Publication

    Protein-protein interaction databases

    BioGridi121211. 3 interactions.
    IntActiQ9NPA0. 2 interactions.
    STRINGi9606.ENSP00000256545.

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1B0GX-ray2.50C/F4-12[»]
    1LP9X-ray2.00C/J4-12[»]
    2J8UX-ray2.88C/J4-12[»]
    2JCCX-ray2.50C/J4-12[»]
    2UWEX-ray2.40C/J4-12[»]
    ProteinModelPortaliQ9NPA0.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ9NPA0.

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini24 – 159136ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini181 – 24262CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei160 – 18021HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the EMC7 family.Curated

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG81025.
    HOGENOMiHOG000230739.
    HOVERGENiHBG058796.
    InParanoidiQ9NPA0.
    OMAiMTANDPE.
    OrthoDBiEOG71ZP3F.
    PhylomeDBiQ9NPA0.
    TreeFamiTF106158.

    Family and domain databases

    InterProiIPR013784. Carb-bd-like_fold.
    IPR019008. DUF2012.
    [Graphical view]
    PfamiPF09430. DUF2012. 1 hit.
    [Graphical view]
    SUPFAMiSSF49452. SSF49452. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9NPA0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAAALWGFFP VLLLLLLSGD VQSSEVPGAA AEGSGGSGVG IGDRFKIEGR    50
    AVVPGVKPQD WISAARVLVD GEEHVGFLKT DGSFVVHDIP SGSYVVEVVS 100
    PAYRFDPVRV DITSKGKMRA RYVNYIKTSE VVRLPYPLQM KSSGPPSYFI 150
    KRESWGWTDF LMNPMVMMMV LPLLIFVLLP KVVNTSDPDM RREMEQSMNM 200
    LNSNHELPDV SEFMTRLFSS KSSGKSSSGS SKTGKSGAGK RR 242
    Length:242
    Mass (Da):26,471
    Last modified:October 1, 2000 - v1
    Checksum:iA71930B89A4C2458
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ250344 mRNA. Translation: CAB96539.1.
    AJ245874 mRNA. Translation: CAC01611.1.
    AF242729 mRNA. Translation: AAG44477.1.
    AY358445 mRNA. Translation: AAQ88810.1.
    AK314883 mRNA. Translation: BAG37397.1.
    BC012456 mRNA. Translation: AAH12456.1.
    BC104934 mRNA. Translation: AAI04935.1.
    BC104936 mRNA. Translation: AAI04937.1.
    CCDSiCCDS10032.1.
    RefSeqiNP_064539.1. NM_020154.2.
    UniGeneiHs.160565.

    Genome annotation databases

    EnsembliENST00000256545; ENSP00000256545; ENSG00000134153.
    GeneIDi56851.
    KEGGihsa:56851.
    UCSCiuc001zhm.3. human.

    Polymorphism databases

    DMDMi74752878.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ250344 mRNA. Translation: CAB96539.1 .
    AJ245874 mRNA. Translation: CAC01611.1 .
    AF242729 mRNA. Translation: AAG44477.1 .
    AY358445 mRNA. Translation: AAQ88810.1 .
    AK314883 mRNA. Translation: BAG37397.1 .
    BC012456 mRNA. Translation: AAH12456.1 .
    BC104934 mRNA. Translation: AAI04935.1 .
    BC104936 mRNA. Translation: AAI04937.1 .
    CCDSi CCDS10032.1.
    RefSeqi NP_064539.1. NM_020154.2.
    UniGenei Hs.160565.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1B0G X-ray 2.50 C/F 4-12 [» ]
    1LP9 X-ray 2.00 C/J 4-12 [» ]
    2J8U X-ray 2.88 C/J 4-12 [» ]
    2JCC X-ray 2.50 C/J 4-12 [» ]
    2UWE X-ray 2.40 C/J 4-12 [» ]
    ProteinModelPortali Q9NPA0.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 121211. 3 interactions.
    IntActi Q9NPA0. 2 interactions.
    STRINGi 9606.ENSP00000256545.

    PTM databases

    PhosphoSitei Q9NPA0.

    Polymorphism databases

    DMDMi 74752878.

    Proteomic databases

    MaxQBi Q9NPA0.
    PaxDbi Q9NPA0.
    PRIDEi Q9NPA0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000256545 ; ENSP00000256545 ; ENSG00000134153 .
    GeneIDi 56851.
    KEGGi hsa:56851.
    UCSCi uc001zhm.3. human.

    Organism-specific databases

    CTDi 56851.
    GeneCardsi GC15M034377.
    H-InvDB HIX0012085.
    HGNCi HGNC:24301. EMC7.
    HPAi HPA010029.
    neXtProti NX_Q9NPA0.
    PharmGKBi PA134900493.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG81025.
    HOGENOMi HOG000230739.
    HOVERGENi HBG058796.
    InParanoidi Q9NPA0.
    OMAi MTANDPE.
    OrthoDBi EOG71ZP3F.
    PhylomeDBi Q9NPA0.
    TreeFami TF106158.

    Miscellaneous databases

    EvolutionaryTracei Q9NPA0.
    GenomeRNAii 56851.
    NextBioi 62258.
    PROi Q9NPA0.

    Gene expression databases

    ArrayExpressi Q9NPA0.
    Bgeei Q9NPA0.
    CleanExi HS_C15orf24.
    Genevestigatori Q9NPA0.

    Family and domain databases

    InterProi IPR013784. Carb-bd-like_fold.
    IPR019008. DUF2012.
    [Graphical view ]
    Pfami PF09430. DUF2012. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49452. SSF49452. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Full-length of some new muscular transcript."
      Ievolella C., Lanfranchi G.
      Submitted (AUG-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Muscle.
    3. Xu X., Yang Y., Gao G., Xiao H., Chen Z., Han Z.
      Submitted (MAR-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Hypothalamus.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain cortex and Lung.
    7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    8. Cited for: IDENTIFICATION IN THE EMC COMPLEX, SUBCELLULAR LOCATION.
    9. "Single MHC mutation eliminates enthalpy associated with T cell receptor binding."
      Miller P.J., Pazy Y., Conti B., Riddle D., Appella E., Collins E.J.
      J. Mol. Biol. 373:315-327(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) OF 4-12.

    Entry informationi

    Entry nameiEMC7_HUMAN
    AccessioniPrimary (citable) accession number: Q9NPA0
    Secondary accession number(s): B2RC00, Q96ED5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 27, 2006
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 99 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Caution

    Has been termed C11orf3, but is not the official C11orf3 as defined by HGNC and furthermore maps to chromosome 15.1 Publication

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 15
      Human chromosome 15: entries, gene names and cross-references to MIM
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3