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Q9NPA0 (EMC7_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 95. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
ER membrane protein complex subunit 7
Gene names
Name:EMC7
Synonyms:C11orf3, C15orf24
ORF Names:HT022, UNQ905/PRO1926
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length242 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Subunit structure

Component of the ER membrane protein complex (EMC). Ref.8

Subcellular location

Membrane; Single-pass type I membrane protein Ref.8.

Sequence similarities

Belongs to the EMC7 family.

Caution

Has been termed C11orf3 (Ref.1), but is not the official C11orf3 as defined by HGNC and furthermore maps to chromosome 15.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2323 Potential
Chain24 – 242219ER membrane protein complex subunit 7
PRO_0000240860

Regions

Topological domain24 – 159136Extracellular Potential
Transmembrane160 – 18021Helical; Potential
Topological domain181 – 24262Cytoplasmic Potential

Sequences

Sequence LengthMass (Da)Tools
Q9NPA0 [UniParc].

Last modified October 1, 2000. Version 1.
Checksum: A71930B89A4C2458

FASTA24226,471
        10         20         30         40         50         60 
MAAALWGFFP VLLLLLLSGD VQSSEVPGAA AEGSGGSGVG IGDRFKIEGR AVVPGVKPQD 

        70         80         90        100        110        120 
WISAARVLVD GEEHVGFLKT DGSFVVHDIP SGSYVVEVVS PAYRFDPVRV DITSKGKMRA 

       130        140        150        160        170        180 
RYVNYIKTSE VVRLPYPLQM KSSGPPSYFI KRESWGWTDF LMNPMVMMMV LPLLIFVLLP 

       190        200        210        220        230        240 
KVVNTSDPDM RREMEQSMNM LNSNHELPDV SEFMTRLFSS KSSGKSSSGS SKTGKSGAGK 


RR 

« Hide

References

« Hide 'large scale' references
[1]"Characterization of five novel human genes in the 11q13-q22 region."
O'Brien K.P., Tapia-Paez I., Staahle-Baeckdahl M., Kedra D., Dumanski J.P.
Biochem. Biophys. Res. Commun. 273:90-94(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Full-length of some new muscular transcript."
Ievolella C., Lanfranchi G.
Submitted (AUG-1999) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Muscle.
[3]Xu X., Yang Y., Gao G., Xiao H., Chen Z., Han Z.
Submitted (MAR-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Hypothalamus.
[4]"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. expand/collapse author list , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.
Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[5]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[6]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain cortex and Lung.
[7]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[8]"Defining human ERAD networks through an integrative mapping strategy."
Christianson J.C., Olzmann J.A., Shaler T.A., Sowa M.E., Bennett E.J., Richter C.M., Tyler R.E., Greenblatt E.J., Harper J.W., Kopito R.R.
Nat. Cell Biol. 14:93-105(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION IN THE EMC COMPLEX, SUBCELLULAR LOCATION.
[9]"Single MHC mutation eliminates enthalpy associated with T cell receptor binding."
Miller P.J., Pazy Y., Conti B., Riddle D., Appella E., Collins E.J.
J. Mol. Biol. 373:315-327(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) OF 4-12.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ250344 mRNA. Translation: CAB96539.1.
AJ245874 mRNA. Translation: CAC01611.1.
AF242729 mRNA. Translation: AAG44477.1.
AY358445 mRNA. Translation: AAQ88810.1.
AK314883 mRNA. Translation: BAG37397.1.
BC012456 mRNA. Translation: AAH12456.1.
BC104934 mRNA. Translation: AAI04935.1.
BC104936 mRNA. Translation: AAI04937.1.
RefSeqNP_064539.1. NM_020154.2.
UniGeneHs.160565.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2UWEX-ray2.40C/J4-12[»]
ProteinModelPortalQ9NPA0.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid121211. 3 interactions.
IntActQ9NPA0. 2 interactions.
STRING9606.ENSP00000256545.

PTM databases

PhosphoSiteQ9NPA0.

Polymorphism databases

DMDM74752878.

Proteomic databases

PaxDbQ9NPA0.
PRIDEQ9NPA0.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000256545; ENSP00000256545; ENSG00000134153.
GeneID56851.
KEGGhsa:56851.
UCSCuc001zhm.3. human.

Organism-specific databases

CTD56851.
GeneCardsGC15M034377.
H-InvDBHIX0012085.
HGNCHGNC:24301. EMC7.
HPAHPA010029.
neXtProtNX_Q9NPA0.
PharmGKBPA134900493.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG81025.
HOGENOMHOG000230739.
HOVERGENHBG058796.
InParanoidQ9NPA0.
OMAMTANDPE.
OrthoDBEOG71ZP3F.
PhylomeDBQ9NPA0.
TreeFamTF106158.

Gene expression databases

ArrayExpressQ9NPA0.
BgeeQ9NPA0.
CleanExHS_C15orf24.
GenevestigatorQ9NPA0.

Family and domain databases

InterProIPR013784. Carb-bd-like_fold.
IPR019008. DUF2012.
[Graphical view]
PfamPF09430. DUF2012. 1 hit.
[Graphical view]
SUPFAMSSF49452. SSF49452. 1 hit.
ProtoNetSearch...

Other

EvolutionaryTraceQ9NPA0.
GenomeRNAi56851.
NextBio62258.
PROQ9NPA0.

Entry information

Entry nameEMC7_HUMAN
AccessionPrimary (citable) accession number: Q9NPA0
Secondary accession number(s): B2RC00, Q96ED5
Entry history
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: October 1, 2000
Last modified: April 16, 2014
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

Human chromosome 15

Human chromosome 15: entries, gene names and cross-references to MIM