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Protein

ER membrane protein complex subunit 7

Gene

EMC7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:ENSG00000134153-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
ER membrane protein complex subunit 7
Gene namesi
Name:EMC7
Synonyms:C11orf3, C15orf24
ORF Names:HT022, UNQ905/PRO1926
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

HGNCiHGNC:24301. EMC7.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini24 – 159ExtracellularSequence analysisAdd BLAST136
Transmembranei160 – 180HelicalSequence analysisAdd BLAST21
Topological domaini181 – 242CytoplasmicSequence analysisAdd BLAST62

GO - Cellular componenti

  • ER membrane protein complex Source: UniProtKB
  • integral component of membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi56851.
OpenTargetsiENSG00000134153.
PharmGKBiPA134900493.

Polymorphism and mutation databases

BioMutaiEMC7.
DMDMi74752878.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisCombined sourcesAdd BLAST23
ChainiPRO_000024086024 – 242ER membrane protein complex subunit 7Add BLAST219

Proteomic databases

EPDiQ9NPA0.
MaxQBiQ9NPA0.
PaxDbiQ9NPA0.
PeptideAtlasiQ9NPA0.
PRIDEiQ9NPA0.

PTM databases

iPTMnetiQ9NPA0.
PhosphoSitePlusiQ9NPA0.

Expressioni

Gene expression databases

BgeeiENSG00000134153.
CleanExiHS_C15orf24.
ExpressionAtlasiQ9NPA0. baseline and differential.
GenevisibleiQ9NPA0. HS.

Organism-specific databases

HPAiHPA010029.
HPA047572.

Interactioni

Subunit structurei

Component of the ER membrane protein complex (EMC).1 Publication

Protein-protein interaction databases

BioGridi121211. 36 interactors.
IntActiQ9NPA0. 18 interactors.
STRINGi9606.ENSP00000256545.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1B0GX-ray2.50C/F4-12[»]
1LP9X-ray2.00C/J4-12[»]
2J8UX-ray2.88C/J4-12[»]
2JCCX-ray2.50C/J4-12[»]
2UWEX-ray2.40C/J4-12[»]
ProteinModelPortaliQ9NPA0.
SMRiQ9NPA0.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9NPA0.

Family & Domainsi

Sequence similaritiesi

Belongs to the EMC7 family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3306. Eukaryota.
ENOG4111IA7. LUCA.
GeneTreeiENSGT00390000017490.
HOGENOMiHOG000230739.
HOVERGENiHBG058796.
InParanoidiQ9NPA0.
OMAiPKVVNTN.
OrthoDBiEOG091G0MDG.
PhylomeDBiQ9NPA0.
TreeFamiTF106158.

Family and domain databases

Gene3Di2.60.40.1120. 1 hit.
InterProiIPR013784. Carb-bd-like_fold.
IPR014766. CarboxyPept_regulatory_dom.
IPR019008. DUF2012.
[Graphical view]
PfamiPF09430. DUF2012. 1 hit.
[Graphical view]
SUPFAMiSSF49452. SSF49452. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9NPA0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAALWGFFP VLLLLLLSGD VQSSEVPGAA AEGSGGSGVG IGDRFKIEGR
60 70 80 90 100
AVVPGVKPQD WISAARVLVD GEEHVGFLKT DGSFVVHDIP SGSYVVEVVS
110 120 130 140 150
PAYRFDPVRV DITSKGKMRA RYVNYIKTSE VVRLPYPLQM KSSGPPSYFI
160 170 180 190 200
KRESWGWTDF LMNPMVMMMV LPLLIFVLLP KVVNTSDPDM RREMEQSMNM
210 220 230 240
LNSNHELPDV SEFMTRLFSS KSSGKSSSGS SKTGKSGAGK RR
Length:242
Mass (Da):26,471
Last modified:October 1, 2000 - v1
Checksum:iA71930B89A4C2458
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ250344 mRNA. Translation: CAB96539.1.
AJ245874 mRNA. Translation: CAC01611.1.
AF242729 mRNA. Translation: AAG44477.1.
AY358445 mRNA. Translation: AAQ88810.1.
AK314883 mRNA. Translation: BAG37397.1.
BC012456 mRNA. Translation: AAH12456.1.
BC104934 mRNA. Translation: AAI04935.1.
BC104936 mRNA. Translation: AAI04937.1.
CCDSiCCDS10032.1.
RefSeqiNP_064539.1. NM_020154.2.
UniGeneiHs.160565.

Genome annotation databases

EnsembliENST00000256545; ENSP00000256545; ENSG00000134153.
GeneIDi56851.
KEGGihsa:56851.
UCSCiuc001zhm.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ250344 mRNA. Translation: CAB96539.1.
AJ245874 mRNA. Translation: CAC01611.1.
AF242729 mRNA. Translation: AAG44477.1.
AY358445 mRNA. Translation: AAQ88810.1.
AK314883 mRNA. Translation: BAG37397.1.
BC012456 mRNA. Translation: AAH12456.1.
BC104934 mRNA. Translation: AAI04935.1.
BC104936 mRNA. Translation: AAI04937.1.
CCDSiCCDS10032.1.
RefSeqiNP_064539.1. NM_020154.2.
UniGeneiHs.160565.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1B0GX-ray2.50C/F4-12[»]
1LP9X-ray2.00C/J4-12[»]
2J8UX-ray2.88C/J4-12[»]
2JCCX-ray2.50C/J4-12[»]
2UWEX-ray2.40C/J4-12[»]
ProteinModelPortaliQ9NPA0.
SMRiQ9NPA0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121211. 36 interactors.
IntActiQ9NPA0. 18 interactors.
STRINGi9606.ENSP00000256545.

PTM databases

iPTMnetiQ9NPA0.
PhosphoSitePlusiQ9NPA0.

Polymorphism and mutation databases

BioMutaiEMC7.
DMDMi74752878.

Proteomic databases

EPDiQ9NPA0.
MaxQBiQ9NPA0.
PaxDbiQ9NPA0.
PeptideAtlasiQ9NPA0.
PRIDEiQ9NPA0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000256545; ENSP00000256545; ENSG00000134153.
GeneIDi56851.
KEGGihsa:56851.
UCSCiuc001zhm.4. human.

Organism-specific databases

CTDi56851.
DisGeNETi56851.
GeneCardsiEMC7.
H-InvDBHIX0012085.
HGNCiHGNC:24301. EMC7.
HPAiHPA010029.
HPA047572.
neXtProtiNX_Q9NPA0.
OpenTargetsiENSG00000134153.
PharmGKBiPA134900493.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3306. Eukaryota.
ENOG4111IA7. LUCA.
GeneTreeiENSGT00390000017490.
HOGENOMiHOG000230739.
HOVERGENiHBG058796.
InParanoidiQ9NPA0.
OMAiPKVVNTN.
OrthoDBiEOG091G0MDG.
PhylomeDBiQ9NPA0.
TreeFamiTF106158.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000134153-MONOMER.

Miscellaneous databases

EvolutionaryTraceiQ9NPA0.
GenomeRNAii56851.
PROiQ9NPA0.

Gene expression databases

BgeeiENSG00000134153.
CleanExiHS_C15orf24.
ExpressionAtlasiQ9NPA0. baseline and differential.
GenevisibleiQ9NPA0. HS.

Family and domain databases

Gene3Di2.60.40.1120. 1 hit.
InterProiIPR013784. Carb-bd-like_fold.
IPR014766. CarboxyPept_regulatory_dom.
IPR019008. DUF2012.
[Graphical view]
PfamiPF09430. DUF2012. 1 hit.
[Graphical view]
SUPFAMiSSF49452. SSF49452. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiEMC7_HUMAN
AccessioniPrimary (citable) accession number: Q9NPA0
Secondary accession number(s): B2RC00, Q96ED5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: October 1, 2000
Last modified: November 30, 2016
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Has been termed C11orf3, but is not the official C11orf3 as defined by HGNC and furthermore maps to chromosome 15.1 Publication

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
  4. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.