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Q9NPA0

- EMC7_HUMAN

UniProt

Q9NPA0 - EMC7_HUMAN

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Protein

ER membrane protein complex subunit 7

Gene

EMC7

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. carbohydrate binding Source: InterPro
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
ER membrane protein complex subunit 7
Gene namesi
Name:EMC7
Synonyms:C11orf3, C15orf24
ORF Names:HT022, UNQ905/PRO1926
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 15

Organism-specific databases

HGNCiHGNC:24301. EMC7.

Subcellular locationi

Membrane 1 Publication; Single-pass type I membrane protein 1 Publication

GO - Cellular componenti

  1. ER membrane protein complex Source: UniProtKB
  2. integral component of membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134900493.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323Sequence AnalysisAdd
BLAST
Chaini24 – 242219ER membrane protein complex subunit 7PRO_0000240860Add
BLAST

Proteomic databases

MaxQBiQ9NPA0.
PaxDbiQ9NPA0.
PRIDEiQ9NPA0.

PTM databases

PhosphoSiteiQ9NPA0.

Expressioni

Gene expression databases

BgeeiQ9NPA0.
CleanExiHS_C15orf24.
ExpressionAtlasiQ9NPA0. baseline and differential.
GenevestigatoriQ9NPA0.

Organism-specific databases

HPAiHPA010029.

Interactioni

Subunit structurei

Component of the ER membrane protein complex (EMC).1 Publication

Protein-protein interaction databases

BioGridi121211. 13 interactions.
IntActiQ9NPA0. 2 interactions.
STRINGi9606.ENSP00000256545.

Structurei

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1B0GX-ray2.50C/F4-12[»]
1LP9X-ray2.00C/J4-12[»]
2J8UX-ray2.88C/J4-12[»]
2JCCX-ray2.50C/J4-12[»]
2UWEX-ray2.40C/J4-12[»]
ProteinModelPortaliQ9NPA0.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9NPA0.

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini24 – 159136ExtracellularSequence AnalysisAdd
BLAST
Topological domaini181 – 24262CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei160 – 18021HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the EMC7 family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG81025.
GeneTreeiENSGT00390000017490.
HOGENOMiHOG000230739.
HOVERGENiHBG058796.
InParanoidiQ9NPA0.
OMAiMTANDPE.
OrthoDBiEOG71ZP3F.
PhylomeDBiQ9NPA0.
TreeFamiTF106158.

Family and domain databases

InterProiIPR013784. Carb-bd-like_fold.
IPR019008. DUF2012.
[Graphical view]
PfamiPF09430. DUF2012. 1 hit.
[Graphical view]
SUPFAMiSSF49452. SSF49452. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9NPA0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAAALWGFFP VLLLLLLSGD VQSSEVPGAA AEGSGGSGVG IGDRFKIEGR
60 70 80 90 100
AVVPGVKPQD WISAARVLVD GEEHVGFLKT DGSFVVHDIP SGSYVVEVVS
110 120 130 140 150
PAYRFDPVRV DITSKGKMRA RYVNYIKTSE VVRLPYPLQM KSSGPPSYFI
160 170 180 190 200
KRESWGWTDF LMNPMVMMMV LPLLIFVLLP KVVNTSDPDM RREMEQSMNM
210 220 230 240
LNSNHELPDV SEFMTRLFSS KSSGKSSSGS SKTGKSGAGK RR
Length:242
Mass (Da):26,471
Last modified:October 1, 2000 - v1
Checksum:iA71930B89A4C2458
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ250344 mRNA. Translation: CAB96539.1.
AJ245874 mRNA. Translation: CAC01611.1.
AF242729 mRNA. Translation: AAG44477.1.
AY358445 mRNA. Translation: AAQ88810.1.
AK314883 mRNA. Translation: BAG37397.1.
BC012456 mRNA. Translation: AAH12456.1.
BC104934 mRNA. Translation: AAI04935.1.
BC104936 mRNA. Translation: AAI04937.1.
CCDSiCCDS10032.1.
RefSeqiNP_064539.1. NM_020154.2.
UniGeneiHs.160565.

Genome annotation databases

EnsembliENST00000256545; ENSP00000256545; ENSG00000134153.
GeneIDi56851.
KEGGihsa:56851.
UCSCiuc001zhm.3. human.

Polymorphism databases

DMDMi74752878.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ250344 mRNA. Translation: CAB96539.1 .
AJ245874 mRNA. Translation: CAC01611.1 .
AF242729 mRNA. Translation: AAG44477.1 .
AY358445 mRNA. Translation: AAQ88810.1 .
AK314883 mRNA. Translation: BAG37397.1 .
BC012456 mRNA. Translation: AAH12456.1 .
BC104934 mRNA. Translation: AAI04935.1 .
BC104936 mRNA. Translation: AAI04937.1 .
CCDSi CCDS10032.1.
RefSeqi NP_064539.1. NM_020154.2.
UniGenei Hs.160565.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1B0G X-ray 2.50 C/F 4-12 [» ]
1LP9 X-ray 2.00 C/J 4-12 [» ]
2J8U X-ray 2.88 C/J 4-12 [» ]
2JCC X-ray 2.50 C/J 4-12 [» ]
2UWE X-ray 2.40 C/J 4-12 [» ]
ProteinModelPortali Q9NPA0.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 121211. 13 interactions.
IntActi Q9NPA0. 2 interactions.
STRINGi 9606.ENSP00000256545.

PTM databases

PhosphoSitei Q9NPA0.

Polymorphism databases

DMDMi 74752878.

Proteomic databases

MaxQBi Q9NPA0.
PaxDbi Q9NPA0.
PRIDEi Q9NPA0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000256545 ; ENSP00000256545 ; ENSG00000134153 .
GeneIDi 56851.
KEGGi hsa:56851.
UCSCi uc001zhm.3. human.

Organism-specific databases

CTDi 56851.
GeneCardsi GC15M034377.
H-InvDB HIX0012085.
HGNCi HGNC:24301. EMC7.
HPAi HPA010029.
neXtProti NX_Q9NPA0.
PharmGKBi PA134900493.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG81025.
GeneTreei ENSGT00390000017490.
HOGENOMi HOG000230739.
HOVERGENi HBG058796.
InParanoidi Q9NPA0.
OMAi MTANDPE.
OrthoDBi EOG71ZP3F.
PhylomeDBi Q9NPA0.
TreeFami TF106158.

Miscellaneous databases

EvolutionaryTracei Q9NPA0.
GenomeRNAii 56851.
NextBioi 62258.
PROi Q9NPA0.

Gene expression databases

Bgeei Q9NPA0.
CleanExi HS_C15orf24.
ExpressionAtlasi Q9NPA0. baseline and differential.
Genevestigatori Q9NPA0.

Family and domain databases

InterProi IPR013784. Carb-bd-like_fold.
IPR019008. DUF2012.
[Graphical view ]
Pfami PF09430. DUF2012. 1 hit.
[Graphical view ]
SUPFAMi SSF49452. SSF49452. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Full-length of some new muscular transcript."
    Ievolella C., Lanfranchi G.
    Submitted (AUG-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Muscle.
  3. Xu X., Yang Y., Gao G., Xiao H., Chen Z., Han Z.
    Submitted (MAR-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Hypothalamus.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain cortex and Lung.
  7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  8. Cited for: IDENTIFICATION IN THE EMC COMPLEX, SUBCELLULAR LOCATION.
  9. "Single MHC mutation eliminates enthalpy associated with T cell receptor binding."
    Miller P.J., Pazy Y., Conti B., Riddle D., Appella E., Collins E.J.
    J. Mol. Biol. 373:315-327(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) OF 4-12.

Entry informationi

Entry nameiEMC7_HUMAN
AccessioniPrimary (citable) accession number: Q9NPA0
Secondary accession number(s): B2RC00, Q96ED5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: October 1, 2000
Last modified: October 29, 2014
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Has been termed C11orf3, but is not the official C11orf3 as defined by HGNC and furthermore maps to chromosome 15.1 Publication

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3