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Protein

Triggering receptor expressed on myeloid cells 1

Gene

TREM1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Stimulates neutrophil and monocyte-mediated inflammatory responses. Triggers release of pro-inflammatory chemokines and cytokines, as well as increased surface expression of cell activation markers. Amplifier of inflammatory responses that are triggered by bacterial and fungal infections and is a crucial mediator of septic shock.2 Publications

GO - Molecular functioni

  • receptor activity Source: ProtInc
  • scaffold protein binding Source: BHF-UCL

GO - Biological processi

  • humoral immune response Source: ProtInc
  • innate immune response Source: Reactome
  • intracellular signal transduction Source: ProtInc
  • leukocyte migration Source: Reactome
  • regulation of immune response Source: Reactome

Keywordsi

Molecular functionReceptor

Enzyme and pathway databases

ReactomeiR-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
R-HSA-202733 Cell surface interactions at the vascular wall
R-HSA-2172127 DAP12 interactions

Names & Taxonomyi

Protein namesi
Recommended name:
Triggering receptor expressed on myeloid cells 1
Short name:
TREM-1
Alternative name(s):
Triggering receptor expressed on monocytes 1
CD_antigen: CD354
Gene namesi
Name:TREM1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000124731.12
HGNCiHGNC:17760 TREM1
MIMi605085 gene
neXtProtiNX_Q9NP99

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini21 – 205ExtracellularSequence analysisAdd BLAST185
Transmembranei206 – 226HelicalSequence analysisAdd BLAST21
Topological domaini227 – 234CytoplasmicSequence analysis8

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi54210
OpenTargetsiENSG00000124731
PharmGKBiPA38467

Chemistry databases

ChEMBLiCHEMBL1697674
DrugBankiDB01694 D-tartaric acid

Polymorphism and mutation databases

BioMutaiTREM1
DMDMi50401685

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_000001498621 – 234Triggering receptor expressed on myeloid cells 1Add BLAST214

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi41 ↔ 113Combined sources2 Publications
Glycosylationi146N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi191N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi194N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

Glycosylated.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9NP99
PeptideAtlasiQ9NP99
PRIDEiQ9NP99

PTM databases

iPTMnetiQ9NP99
PhosphoSitePlusiQ9NP99

Expressioni

Tissue specificityi

Highly expressed in adult liver, lung and spleen than in corresponding fetal tissue. Also expressed in the lymph node, placenta, spinal cord and heart tissues. Expression is more elevated in peripheral blood leukocytes than in the bone marrow and in normal cells than malignant cells. Expressed at low levels in the early development of the hematopoietic system and in the promonocytic stage and at high levels in mature monocytes. Strongly expressed in acute inflammatory lesions caused by bacteria and fungi. Isoform 2 was detected in the lung, liver and mature monocytes.2 Publications

Inductioni

Up-regulated by bacteria, fungi and bacterial lipopolysaccharides (LPS).1 Publication

Gene expression databases

BgeeiENSG00000124731
CleanExiHS_TREM1
ExpressionAtlasiQ9NP99 baseline and differential
GenevisibleiQ9NP99 HS

Organism-specific databases

HPAiHPA005563

Interactioni

Subunit structurei

Interacts with TYROBP/DAP12.2 Publications

GO - Molecular functioni

  • scaffold protein binding Source: BHF-UCL

Protein-protein interaction databases

BioGridi119926, 9 interactors
IntActiQ9NP99, 2 interactors
STRINGi9606.ENSP00000244709

Structurei

Secondary structure

1234
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi22 – 30Combined sources9
Beta strandi37 – 42Combined sources6
Helixi45 – 48Combined sources4
Beta strandi53 – 58Combined sources6
Turni60 – 62Combined sources3
Beta strandi65 – 69Combined sources5
Beta strandi80 – 82Combined sources3
Beta strandi85 – 90Combined sources6
Turni91 – 94Combined sources4
Beta strandi95 – 100Combined sources6
Helixi105 – 107Combined sources3
Beta strandi109 – 115Combined sources7
Beta strandi123 – 125Combined sources3
Beta strandi128 – 132Combined sources5

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1Q8MX-ray2.60A/B/C/D17-134[»]
1SMOX-ray1.47A/B21-139[»]
ProteinModelPortaliQ9NP99
SMRiQ9NP99
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9NP99

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini26 – 134Ig-like V-typeAdd BLAST109

Keywords - Domaini

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J3SD Eukaryota
ENOG4111ABH LUCA
GeneTreeiENSGT00470000042299
HOGENOMiHOG000130964
HOVERGENiHBG068403
InParanoidiQ9NP99
KOiK14362
OMAiMRKARLW
PhylomeDBiQ9NP99
TreeFamiTF339293

Family and domain databases

Gene3Di2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR013106 Ig_V-set
PfamiView protein in Pfam
PF07686 V-set, 1 hit
SMARTiView protein in SMART
SM00409 IG, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9NP99-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRKTRLWGLL WMLFVSELRA ATKLTEEKYE LKEGQTLDVK CDYTLEKFAS
60 70 80 90 100
SQKAWQIIRD GEMPKTLACT ERPSKNSHPV QVGRIILEDY HDHGLLRVRM
110 120 130 140 150
VNLQVEDSGL YQCVIYQPPK EPHMLFDRIR LVVTKGFSGT PGSNENSTQN
160 170 180 190 200
VYKIPPTTTK ALCPLYTSPR TVTQAPPKST ADVSTPDSEI NLTNVTDIIR
210 220 230
VPVFNIVILL AGGFLSKSLV FSVLFAVTLR SFVP
Length:234
Mass (Da):26,387
Last modified:October 1, 2000 - v1
Checksum:iAA114696E35D4D45
GO
Isoform 2 (identifier: Q9NP99-2) [UniParc]FASTAAdd to basket
Also known as: TREM-1sv, sTREM1

The sequence of this isoform differs from the canonical sequence as follows:
     138-150: SGTPGSNENSTQN → RCSTLSFSWLVDS
     151-234: Missing.

Show »
Length:150
Mass (Da):17,563
Checksum:iDEC9D0CA30FDF84E
GO
Isoform 3 (identifier: Q9NP99-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     201-234: VPVFNIVILLAGGFLSKSLVFSVLFAVTLRSFVP → YSFQVPGPLVWTLSPLFPSLCAERM

Show »
Length:225
Mass (Da):25,574
Checksum:iEB7B454E4904B203
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti35Q → K in AAL74018 (Ref. 3) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01933325T → S1 PublicationCorresponds to variant dbSNP:rs2234237Ensembl.1
Natural variantiVAR_03552597R → S in a breast cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_049949135K → T. Corresponds to variant dbSNP:rs34727391Ensembl.1
Natural variantiVAR_033624214F → L. Corresponds to variant dbSNP:rs2234245Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_010790138 – 150SGTPG…NSTQN → RCSTLSFSWLVDS in isoform 2. 3 PublicationsAdd BLAST13
Alternative sequenceiVSP_010791151 – 234Missing in isoform 2. 3 PublicationsAdd BLAST84
Alternative sequenceiVSP_053939201 – 234VPVFN…RSFVP → YSFQVPGPLVWTLSPLFPSL CAERM in isoform 3. CuratedAdd BLAST34

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF196329 mRNA Translation: AAF71694.1
AF287008 mRNA Translation: AAF90197.1
AY074783 mRNA Translation: AAL74018.1
AK301519 mRNA Translation: BAG63024.1
AL391903 Genomic DNA No translation available.
BC017773 mRNA Translation: AAH17773.1
AK223264 mRNA Translation: BAD96984.1
CCDSiCCDS4854.1 [Q9NP99-1]
CCDS56427.1 [Q9NP99-2]
CCDS59499.1 [Q9NP99-3]
RefSeqiNP_001229518.1, NM_001242589.2 [Q9NP99-3]
NP_001229519.1, NM_001242590.2 [Q9NP99-2]
NP_061113.1, NM_018643.4 [Q9NP99-1]
XP_016866445.1, XM_017010956.1 [Q9NP99-1]
XP_016866446.1, XM_017010957.1 [Q9NP99-2]
UniGeneiHs.283022
Hs.435955

Genome annotation databases

EnsembliENST00000244709; ENSP00000244709; ENSG00000124731 [Q9NP99-1]
ENST00000334475; ENSP00000334284; ENSG00000124731 [Q9NP99-2]
ENST00000591620; ENSP00000465345; ENSG00000124731 [Q9NP99-3]
GeneIDi54210
KEGGihsa:54210
UCSCiuc003oqf.3 human [Q9NP99-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiTREM1_HUMAN
AccessioniPrimary (citable) accession number: Q9NP99
Secondary accession number(s): B4DWG2
, K7EJW1, Q53FL8, Q5T2C9, Q86YU1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: October 1, 2000
Last modified: March 28, 2018
This is version 150 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
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Main funding by: National Institutes of Health