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Protein

Triggering receptor expressed on myeloid cells 1

Gene

TREM1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Stimulates neutrophil and monocyte-mediated inflammatory responses. Triggers release of pro-inflammatory chemokines and cytokines, as well as increased surface expression of cell activation markers. Amplifier of inflammatory responses that are triggered by bacterial and fungal infections and is a crucial mediator of septic shock.2 Publications

GO - Molecular functioni

  • receptor activity Source: ProtInc
  • scaffold protein binding Source: BHF-UCL

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Receptor

Enzyme and pathway databases

BioCyciZFISH:ENSG00000124731-MONOMER.
ReactomeiR-HSA-198933. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
R-HSA-202733. Cell surface interactions at the vascular wall.
R-HSA-2172127. DAP12 interactions.

Names & Taxonomyi

Protein namesi
Recommended name:
Triggering receptor expressed on myeloid cells 1
Short name:
TREM-1
Alternative name(s):
Triggering receptor expressed on monocytes 1
CD_antigen: CD354
Gene namesi
Name:TREM1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:17760. TREM1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini21 – 205ExtracellularSequence analysisAdd BLAST185
Transmembranei206 – 226HelicalSequence analysisAdd BLAST21
Topological domaini227 – 234CytoplasmicSequence analysis8

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi54210.
OpenTargetsiENSG00000124731.
PharmGKBiPA38467.

Chemistry databases

ChEMBLiCHEMBL1697674.

Polymorphism and mutation databases

BioMutaiTREM1.
DMDMi50401685.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_000001498621 – 234Triggering receptor expressed on myeloid cells 1Add BLAST214

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi41 ↔ 113Combined sources2 Publications
Glycosylationi146N-linked (GlcNAc...)Sequence analysis1
Glycosylationi191N-linked (GlcNAc...)Sequence analysis1
Glycosylationi194N-linked (GlcNAc...)Sequence analysis1

Post-translational modificationi

Glycosylated.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9NP99.
PeptideAtlasiQ9NP99.
PRIDEiQ9NP99.

PTM databases

iPTMnetiQ9NP99.
PhosphoSitePlusiQ9NP99.

Expressioni

Tissue specificityi

Highly expressed in adult liver, lung and spleen than in corresponding fetal tissue. Also expressed in the lymph node, placenta, spinal cord and heart tissues. Expression is more elevated in peripheral blood leukocytes than in the bone marrow and in normal cells than malignant cells. Expressed at low levels in the early development of the hematopoietic system and in the promonocytic stage and at high levels in mature monocytes. Strongly expressed in acute inflammatory lesions caused by bacteria and fungi. Isoform 2 was detected in the lung, liver and mature monocytes.2 Publications

Inductioni

Up-regulated by bacteria, fungi and bacterial lipopolysaccharides (LPS).1 Publication

Gene expression databases

BgeeiENSG00000124731.
CleanExiHS_TREM1.
ExpressionAtlasiQ9NP99. baseline and differential.
GenevisibleiQ9NP99. HS.

Organism-specific databases

HPAiHPA005563.

Interactioni

Subunit structurei

Interacts with TYROBP/DAP12.2 Publications

GO - Molecular functioni

  • scaffold protein binding Source: BHF-UCL

Protein-protein interaction databases

BioGridi119926. 2 interactors.
STRINGi9606.ENSP00000244709.

Structurei

Secondary structure

1234
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi22 – 30Combined sources9
Beta strandi37 – 42Combined sources6
Helixi45 – 48Combined sources4
Beta strandi53 – 58Combined sources6
Turni60 – 62Combined sources3
Beta strandi65 – 69Combined sources5
Beta strandi80 – 82Combined sources3
Beta strandi85 – 90Combined sources6
Turni91 – 94Combined sources4
Beta strandi95 – 100Combined sources6
Helixi105 – 107Combined sources3
Beta strandi109 – 115Combined sources7
Beta strandi123 – 125Combined sources3
Beta strandi128 – 132Combined sources5

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1Q8MX-ray2.60A/B/C/D17-134[»]
1SMOX-ray1.47A/B21-139[»]
ProteinModelPortaliQ9NP99.
SMRiQ9NP99.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9NP99.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini26 – 134Ig-like V-typeAdd BLAST109

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J3SD. Eukaryota.
ENOG4111ABH. LUCA.
GeneTreeiENSGT00470000042299.
HOGENOMiHOG000130964.
HOVERGENiHBG068403.
InParanoidiQ9NP99.
KOiK14362.
OMAiPVFNIVI.
PhylomeDBiQ9NP99.
TreeFamiTF339293.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9NP99-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRKTRLWGLL WMLFVSELRA ATKLTEEKYE LKEGQTLDVK CDYTLEKFAS
60 70 80 90 100
SQKAWQIIRD GEMPKTLACT ERPSKNSHPV QVGRIILEDY HDHGLLRVRM
110 120 130 140 150
VNLQVEDSGL YQCVIYQPPK EPHMLFDRIR LVVTKGFSGT PGSNENSTQN
160 170 180 190 200
VYKIPPTTTK ALCPLYTSPR TVTQAPPKST ADVSTPDSEI NLTNVTDIIR
210 220 230
VPVFNIVILL AGGFLSKSLV FSVLFAVTLR SFVP
Length:234
Mass (Da):26,387
Last modified:October 1, 2000 - v1
Checksum:iAA114696E35D4D45
GO
Isoform 2 (identifier: Q9NP99-2) [UniParc]FASTAAdd to basket
Also known as: TREM-1sv, sTREM1

The sequence of this isoform differs from the canonical sequence as follows:
     138-150: SGTPGSNENSTQN → RCSTLSFSWLVDS
     151-234: Missing.

Show »
Length:150
Mass (Da):17,563
Checksum:iDEC9D0CA30FDF84E
GO
Isoform 3 (identifier: Q9NP99-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     201-234: VPVFNIVILLAGGFLSKSLVFSVLFAVTLRSFVP → YSFQVPGPLVWTLSPLFPSLCAERM

Show »
Length:225
Mass (Da):25,574
Checksum:iEB7B454E4904B203
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti35Q → K in AAL74018 (Ref. 3) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01933325T → S.1 PublicationCorresponds to variant rs2234237dbSNPEnsembl.1
Natural variantiVAR_03552597R → S in a breast cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_049949135K → T.Corresponds to variant rs34727391dbSNPEnsembl.1
Natural variantiVAR_033624214F → L.Corresponds to variant rs2234245dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_010790138 – 150SGTPG…NSTQN → RCSTLSFSWLVDS in isoform 2. 3 PublicationsAdd BLAST13
Alternative sequenceiVSP_010791151 – 234Missing in isoform 2. 3 PublicationsAdd BLAST84
Alternative sequenceiVSP_053939201 – 234VPVFN…RSFVP → YSFQVPGPLVWTLSPLFPSL CAERM in isoform 3. CuratedAdd BLAST34

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF196329 mRNA. Translation: AAF71694.1.
AF287008 mRNA. Translation: AAF90197.1.
AY074783 mRNA. Translation: AAL74018.1.
AK301519 mRNA. Translation: BAG63024.1.
AL391903 Genomic DNA. Translation: CAI19864.1.
BC017773 mRNA. Translation: AAH17773.1.
AK223264 mRNA. Translation: BAD96984.1.
CCDSiCCDS4854.1. [Q9NP99-1]
CCDS56427.1. [Q9NP99-2]
CCDS59499.1. [Q9NP99-3]
RefSeqiNP_001229518.1. NM_001242589.2. [Q9NP99-3]
NP_001229519.1. NM_001242590.2. [Q9NP99-2]
NP_061113.1. NM_018643.4. [Q9NP99-1]
XP_016866445.1. XM_017010956.1. [Q9NP99-1]
XP_016866446.1. XM_017010957.1. [Q9NP99-2]
UniGeneiHs.283022.
Hs.435955.

Genome annotation databases

EnsembliENST00000244709; ENSP00000244709; ENSG00000124731. [Q9NP99-1]
ENST00000334475; ENSP00000334284; ENSG00000124731. [Q9NP99-2]
ENST00000591620; ENSP00000465345; ENSG00000124731. [Q9NP99-3]
GeneIDi54210.
KEGGihsa:54210.
UCSCiuc003oqf.3. human. [Q9NP99-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF196329 mRNA. Translation: AAF71694.1.
AF287008 mRNA. Translation: AAF90197.1.
AY074783 mRNA. Translation: AAL74018.1.
AK301519 mRNA. Translation: BAG63024.1.
AL391903 Genomic DNA. Translation: CAI19864.1.
BC017773 mRNA. Translation: AAH17773.1.
AK223264 mRNA. Translation: BAD96984.1.
CCDSiCCDS4854.1. [Q9NP99-1]
CCDS56427.1. [Q9NP99-2]
CCDS59499.1. [Q9NP99-3]
RefSeqiNP_001229518.1. NM_001242589.2. [Q9NP99-3]
NP_001229519.1. NM_001242590.2. [Q9NP99-2]
NP_061113.1. NM_018643.4. [Q9NP99-1]
XP_016866445.1. XM_017010956.1. [Q9NP99-1]
XP_016866446.1. XM_017010957.1. [Q9NP99-2]
UniGeneiHs.283022.
Hs.435955.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1Q8MX-ray2.60A/B/C/D17-134[»]
1SMOX-ray1.47A/B21-139[»]
ProteinModelPortaliQ9NP99.
SMRiQ9NP99.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119926. 2 interactors.
STRINGi9606.ENSP00000244709.

Chemistry databases

ChEMBLiCHEMBL1697674.

PTM databases

iPTMnetiQ9NP99.
PhosphoSitePlusiQ9NP99.

Polymorphism and mutation databases

BioMutaiTREM1.
DMDMi50401685.

Proteomic databases

PaxDbiQ9NP99.
PeptideAtlasiQ9NP99.
PRIDEiQ9NP99.

Protocols and materials databases

DNASUi54210.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000244709; ENSP00000244709; ENSG00000124731. [Q9NP99-1]
ENST00000334475; ENSP00000334284; ENSG00000124731. [Q9NP99-2]
ENST00000591620; ENSP00000465345; ENSG00000124731. [Q9NP99-3]
GeneIDi54210.
KEGGihsa:54210.
UCSCiuc003oqf.3. human. [Q9NP99-1]

Organism-specific databases

CTDi54210.
DisGeNETi54210.
GeneCardsiTREM1.
HGNCiHGNC:17760. TREM1.
HPAiHPA005563.
MIMi605085. gene.
neXtProtiNX_Q9NP99.
OpenTargetsiENSG00000124731.
PharmGKBiPA38467.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J3SD. Eukaryota.
ENOG4111ABH. LUCA.
GeneTreeiENSGT00470000042299.
HOGENOMiHOG000130964.
HOVERGENiHBG068403.
InParanoidiQ9NP99.
KOiK14362.
OMAiPVFNIVI.
PhylomeDBiQ9NP99.
TreeFamiTF339293.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000124731-MONOMER.
ReactomeiR-HSA-198933. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
R-HSA-202733. Cell surface interactions at the vascular wall.
R-HSA-2172127. DAP12 interactions.

Miscellaneous databases

EvolutionaryTraceiQ9NP99.
GeneWikiiTREM1.
GenomeRNAii54210.
PROiQ9NP99.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000124731.
CleanExiHS_TREM1.
ExpressionAtlasiQ9NP99. baseline and differential.
GenevisibleiQ9NP99. HS.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiTREM1_HUMAN
AccessioniPrimary (citable) accession number: Q9NP99
Secondary accession number(s): B4DWG2
, K7EJW1, Q53FL8, Q5T2C9, Q86YU1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: October 1, 2000
Last modified: November 2, 2016
This is version 139 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.