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Q9NP98 (MYOZ1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 96. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Myozenin-1
Alternative name(s):
Calsarcin-2
Filamin-, actinin- and telethonin-binding protein
Protein FATZ
Gene names
Name:MYOZ1
Synonyms:MYOZ
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length299 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Myozenins may serve as intracellular binding proteins involved in linking Z-disk proteins such as alpha-actinin, gamma-filamin, TCAP/telethonin, LDB3/ZASP and localizing calcineurin signaling to the sarcomere. Plays an important role in the modulation of calcineurin signaling. May play a role in myofibrillogenesis.

Subunit structure

Interacts with ACTN2, ACTN3, FLNA, FLNB, FLNC, LDB3, PPP3CA and TCAP. Interacts via its C-terminal region with MYOT. Ref.1 Ref.2 Ref.3 Ref.6 Ref.7

Subcellular location

Nucleus. Cell projectionpseudopodium. Note: Localized to the nucleus and pseudopodia of undifferentiated cells and detected throughout the myotubes of differentiated cells. Colocalizes with ACTN2, FLNC and MYOT at the Z-lines of skeletal muscle. Ref.1 Ref.3 Ref.7

Tissue specificity

Expressed primarily in skeletal muscle. Detected at lower levels in heart, prostate and pancreas. Ref.1 Ref.2 Ref.3

Sequence similarities

Belongs to the myozenin family.

Ontologies

Keywords
   Cellular componentCell projection
Nucleus
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processmyofibril assembly

Traceable author statement Ref.2. Source: UniProtKB

   Cellular_componentactin cytoskeleton

Inferred from electronic annotation. Source: Ensembl

nucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

pseudopodium

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionFATZ binding

Inferred from direct assay Ref.1. Source: UniProtKB

protein binding

Inferred from physical interaction PubMed 10427098Ref.1Ref.2Ref.3Ref.6Ref.7. Source: UniProtKB

Complete GO annotation...

Binary interactions

With

Entry

#Exp.

IntAct

Notes

TRIM63Q969Q12EBI-744402,EBI-5661333

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 299299Myozenin-1
PRO_0000111095

Regions

Compositional bias95 – 17581Gly-rich

Experimental info

Sequence conflict1531R → K in AAG38940. Ref.2
Sequence conflict1601A → T in AAG38940. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Q9NP98 [UniParc].

Last modified October 1, 2000. Version 1.
Checksum: AADEB488C66B5E27

FASTA29931,745
        10         20         30         40         50         60 
MPLSGTPAPN KKRKSSKLIM ELTGGGQESS GLNLGKKISV PRDVMLEELS LLTNRGSKMF 

        70         80         90        100        110        120 
KLRQMRVEKF IYENHPDVFS DSSMDHFQKF LPTVGGQLGT AGQGFSYSKS NGRGGSQAGG 

       130        140        150        160        170        180 
SGSAGQYGSD QQHHLGSGSG AGGTGGPAGQ AGRGGAAGTA GVGETGSGDQ AGGEGKHITV 

       190        200        210        220        230        240 
FKTYISPWER AMGVDPQQKM ELGIDLLAYG AKAELPKYKS FNRTAMPYGG YEKASKRMTF 

       250        260        270        280        290 
QMPKFDLGPL LSEPLVLYNQ NLSNRPSFNR TPIPWLSSGE PVDYNVDIGI PLDGETEEL 

« Hide

References

« Hide 'large scale' references
[1]"FATZ, a filamin-, actinin-, and telethonin-binding protein of the Z-disc of skeletal muscle."
Faulkner G., Pallavicini A., Comelli A., Salamon M., Bortoletto G., Ievolella C., Trevisan S., Kojic' S., Dalla Vecchia F., Laveder P., Valle G., Lanfranchi G.
J. Biol. Chem. 275:41234-41242(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], INTERACTION WITH ACTN2; FLNC AND TCAP, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
Tissue: Skeletal muscle.
[2]"Calsarcins, a novel family of sarcomeric calcineurin-binding proteins."
Frey N., Richardson J.A., Olson E.N.
Proc. Natl. Acad. Sci. U.S.A. 97:14632-14637(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], INTERACTION WITH ACTN2 AND PPP3CA, TISSUE SPECIFICITY.
Tissue: Heart.
[3]"Myozenin: an alpha-actinin- and gamma-filamin-binding protein of skeletal muscle Z lines."
Takada F., Vander Woude D.L., Tong H.-Q., Thompson T.G., Watkins S.C., Kunkel L.M., Beggs A.H.
Proc. Natl. Acad. Sci. U.S.A. 98:1595-1600(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], INTERACTION WITH ACTN2; ACTN3 AND FLNC, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
Tissue: Skeletal muscle.
[4]The European IMAGE consortium
Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Lung.
[6]"Calsarcin-3, a novel skeletal muscle-specific member of the calsarcin family, interacts with multiple Z-disc proteins."
Frey N., Olson E.N.
J. Biol. Chem. 277:13998-14004(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH LDB3.
[7]"The Z-disc proteins myotilin and FATZ-1 interact with each other and are connected to the sarcolemma via muscle-specific filamins."
Gontier Y., Taivainen A., Fontao L., Sonnenberg A., van der Flier A., Carpen O., Faulkner G., Borradori L.
J. Cell Sci. 118:3739-3749(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH FLNA; FLNB; FLNC AND MYOT, SUBCELLULAR LOCATION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ278124 mRNA. Translation: CAB92967.1.
AY013297 mRNA. Translation: AAG38940.1.
AF240633 mRNA. Translation: AAG24509.1.
AF243390 expand/collapse EMBL AC list , AF243387, AF243388, AF243389 Genomic DNA. Translation: AAG27296.1.
AL359210 mRNA. Translation: CAB94568.1.
BC025753 mRNA. Translation: AAH25753.1.
CCDSCCDS7330.1.
RefSeqNP_067068.1. NM_021245.3.
UniGeneHs.238756.

3D structure databases

ProteinModelPortalQ9NP98.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid121849. 13 interactions.
IntActQ9NP98. 6 interactions.
MINTMINT-145528.
STRING9606.ENSP00000352272.

PTM databases

PhosphoSiteQ9NP98.

Polymorphism databases

DMDM74734300.

Proteomic databases

PaxDbQ9NP98.
PRIDEQ9NP98.

Protocols and materials databases

DNASU58529.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000359322; ENSP00000352272; ENSG00000177791.
GeneID58529.
KEGGhsa:58529.
UCSCuc001jur.4. human.

Organism-specific databases

CTD58529.
GeneCardsGC10M075391.
HGNCHGNC:13752. MYOZ1.
HPAHPA037848.
MIM605603. gene.
neXtProtNX_Q9NP98.
PharmGKBPA31420.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG79996.
HOGENOMHOG000030910.
HOVERGENHBG071289.
InParanoidQ9NP98.
OMAMPKFDLG.
OrthoDBEOG7B31NQ.
PhylomeDBQ9NP98.
TreeFamTF331748.

Gene expression databases

BgeeQ9NP98.
CleanExHS_MYOZ1.
GenevestigatorQ9NP98.

Family and domain databases

InterProIPR008438. MYOZ.
[Graphical view]
PANTHERPTHR15941. PTHR15941. 1 hit.
PfamPF05556. Calsarcin. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiMYOZ1.
GenomeRNAi58529.
NextBio65102.
PROQ9NP98.
SOURCESearch...

Entry information

Entry nameMYOZ1_HUMAN
AccessionPrimary (citable) accession number: Q9NP98
Secondary accession number(s): Q9H1I7
Entry history
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: October 1, 2000
Last modified: July 9, 2014
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 10

Human chromosome 10: entries, gene names and cross-references to MIM