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Protein

Myozenin-1

Gene

MYOZ1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Myozenins may serve as intracellular binding proteins involved in linking Z-disk proteins such as alpha-actinin, gamma-filamin, TCAP/telethonin, LDB3/ZASP and localizing calcineurin signaling to the sarcomere. Plays an important role in the modulation of calcineurin signaling. May play a role in myofibrillogenesis.

GO - Molecular functioni

  • FATZ binding Source: UniProtKB

GO - Biological processi

  • myofibril assembly Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Myozenin-1
Alternative name(s):
Calsarcin-2
Filamin-, actinin- and telethonin-binding protein
Protein FATZ
Gene namesi
Name:MYOZ1Imported
Synonyms:MYOZImported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 10

Organism-specific databases

HGNCiHGNC:13752. MYOZ1.

Subcellular locationi

  • Nucleus
  • Cell projectionpseudopodium

  • Note: Localized to the nucleus and pseudopodia of undifferentiated cells and detected throughout the myotubes of differentiated cells. Colocalizes with ACTN2, FLNC and MYOT at the Z-lines of skeletal muscle.

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell projection, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA31420.

Polymorphism and mutation databases

BioMutaiMYOZ1.
DMDMi74734300.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 299299Myozenin-1PRO_0000111095Add
BLAST

Proteomic databases

PaxDbiQ9NP98.
PRIDEiQ9NP98.

PTM databases

PhosphoSiteiQ9NP98.

Expressioni

Tissue specificityi

Expressed primarily in skeletal muscle. Detected at lower levels in heart, prostate and pancreas.3 Publications

Gene expression databases

BgeeiQ9NP98.
CleanExiHS_MYOZ1.
GenevestigatoriQ9NP98.

Organism-specific databases

HPAiHPA037848.
HPA038437.

Interactioni

Subunit structurei

Interacts with ACTN2, ACTN3, FLNA, FLNB, FLNC, LDB3, PPP3CA and TCAP. Interacts via its C-terminal region with MYOT.5 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
TRIM63Q969Q12EBI-744402,EBI-5661333

Protein-protein interaction databases

BioGridi121849. 15 interactions.
IntActiQ9NP98. 7 interactions.
MINTiMINT-145528.
STRINGi9606.ENSP00000352272.

Structurei

3D structure databases

ProteinModelPortaliQ9NP98.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi95 – 17581Gly-richSequence AnalysisAdd
BLAST

Sequence similaritiesi

Belongs to the myozenin family.Curated

Phylogenomic databases

eggNOGiNOG79996.
GeneTreeiENSGT00530000063184.
HOGENOMiHOG000030910.
HOVERGENiHBG071289.
InParanoidiQ9NP98.
OMAiMPKFDLG.
OrthoDBiEOG7B31NQ.
PhylomeDBiQ9NP98.
TreeFamiTF331748.

Family and domain databases

InterProiIPR008438. MYOZ.
[Graphical view]
PANTHERiPTHR15941. PTHR15941. 1 hit.
PfamiPF05556. Calsarcin. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9NP98-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPLSGTPAPN KKRKSSKLIM ELTGGGQESS GLNLGKKISV PRDVMLEELS
60 70 80 90 100
LLTNRGSKMF KLRQMRVEKF IYENHPDVFS DSSMDHFQKF LPTVGGQLGT
110 120 130 140 150
AGQGFSYSKS NGRGGSQAGG SGSAGQYGSD QQHHLGSGSG AGGTGGPAGQ
160 170 180 190 200
AGRGGAAGTA GVGETGSGDQ AGGEGKHITV FKTYISPWER AMGVDPQQKM
210 220 230 240 250
ELGIDLLAYG AKAELPKYKS FNRTAMPYGG YEKASKRMTF QMPKFDLGPL
260 270 280 290
LSEPLVLYNQ NLSNRPSFNR TPIPWLSSGE PVDYNVDIGI PLDGETEEL
Length:299
Mass (Da):31,745
Last modified:October 1, 2000 - v1
Checksum:iAADEB488C66B5E27
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti153 – 1531R → K in AAG38940 (PubMed:11114196).Curated
Sequence conflicti160 – 1601A → T in AAG38940 (PubMed:11114196).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ278124 mRNA. Translation: CAB92967.1.
AY013297 mRNA. Translation: AAG38940.1.
AF240633 mRNA. Translation: AAG24509.1.
AF243390
, AF243387, AF243388, AF243389 Genomic DNA. Translation: AAG27296.1.
AL359210 mRNA. Translation: CAB94568.1.
BC025753 mRNA. Translation: AAH25753.1.
CCDSiCCDS7330.1.
RefSeqiNP_067068.1. NM_021245.3.
UniGeneiHs.238756.

Genome annotation databases

EnsembliENST00000359322; ENSP00000352272; ENSG00000177791.
GeneIDi58529.
KEGGihsa:58529.
UCSCiuc001jur.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ278124 mRNA. Translation: CAB92967.1.
AY013297 mRNA. Translation: AAG38940.1.
AF240633 mRNA. Translation: AAG24509.1.
AF243390
, AF243387, AF243388, AF243389 Genomic DNA. Translation: AAG27296.1.
AL359210 mRNA. Translation: CAB94568.1.
BC025753 mRNA. Translation: AAH25753.1.
CCDSiCCDS7330.1.
RefSeqiNP_067068.1. NM_021245.3.
UniGeneiHs.238756.

3D structure databases

ProteinModelPortaliQ9NP98.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121849. 15 interactions.
IntActiQ9NP98. 7 interactions.
MINTiMINT-145528.
STRINGi9606.ENSP00000352272.

PTM databases

PhosphoSiteiQ9NP98.

Polymorphism and mutation databases

BioMutaiMYOZ1.
DMDMi74734300.

Proteomic databases

PaxDbiQ9NP98.
PRIDEiQ9NP98.

Protocols and materials databases

DNASUi58529.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000359322; ENSP00000352272; ENSG00000177791.
GeneIDi58529.
KEGGihsa:58529.
UCSCiuc001jur.4. human.

Organism-specific databases

CTDi58529.
GeneCardsiGC10M075391.
HGNCiHGNC:13752. MYOZ1.
HPAiHPA037848.
HPA038437.
MIMi605603. gene.
neXtProtiNX_Q9NP98.
PharmGKBiPA31420.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG79996.
GeneTreeiENSGT00530000063184.
HOGENOMiHOG000030910.
HOVERGENiHBG071289.
InParanoidiQ9NP98.
OMAiMPKFDLG.
OrthoDBiEOG7B31NQ.
PhylomeDBiQ9NP98.
TreeFamiTF331748.

Miscellaneous databases

GeneWikiiMYOZ1.
GenomeRNAii58529.
NextBioi65102.
PROiQ9NP98.
SOURCEiSearch...

Gene expression databases

BgeeiQ9NP98.
CleanExiHS_MYOZ1.
GenevestigatoriQ9NP98.

Family and domain databases

InterProiIPR008438. MYOZ.
[Graphical view]
PANTHERiPTHR15941. PTHR15941. 1 hit.
PfamiPF05556. Calsarcin. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA], INTERACTION WITH ACTN2; FLNC AND TCAP, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    Tissue: Skeletal muscleImported.
  2. "Calsarcins, a novel family of sarcomeric calcineurin-binding proteins."
    Frey N., Richardson J.A., Olson E.N.
    Proc. Natl. Acad. Sci. U.S.A. 97:14632-14637(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], INTERACTION WITH ACTN2 AND PPP3CA, TISSUE SPECIFICITY.
    Tissue: Heart1 Publication.
  3. "Myozenin: an alpha-actinin- and gamma-filamin-binding protein of skeletal muscle Z lines."
    Takada F., Vander Woude D.L., Tong H.-Q., Thompson T.G., Watkins S.C., Kunkel L.M., Beggs A.H.
    Proc. Natl. Acad. Sci. U.S.A. 98:1595-1600(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], INTERACTION WITH ACTN2; ACTN3 AND FLNC, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    Tissue: Skeletal muscleImported.
  4. The European IMAGE consortium
    Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: LungImported.
  6. "Calsarcin-3, a novel skeletal muscle-specific member of the calsarcin family, interacts with multiple Z-disc proteins."
    Frey N., Olson E.N.
    J. Biol. Chem. 277:13998-14004(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH LDB3.
  7. "The Z-disc proteins myotilin and FATZ-1 interact with each other and are connected to the sarcolemma via muscle-specific filamins."
    Gontier Y., Taivainen A., Fontao L., Sonnenberg A., van der Flier A., Carpen O., Faulkner G., Borradori L.
    J. Cell Sci. 118:3739-3749(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH FLNA; FLNB; FLNC AND MYOT, SUBCELLULAR LOCATION.

Entry informationi

Entry nameiMYOZ1_HUMAN
AccessioniPrimary (citable) accession number: Q9NP98
Secondary accession number(s): Q9H1I7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: October 1, 2000
Last modified: May 27, 2015
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.