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Q9NP98

- MYOZ1_HUMAN

UniProt

Q9NP98 - MYOZ1_HUMAN

Protein

Myozenin-1

Gene

MYOZ1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 97 (01 Oct 2014)
      Sequence version 1 (01 Oct 2000)
      Previous versions | rss
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    Functioni

    Myozenins may serve as intracellular binding proteins involved in linking Z-disk proteins such as alpha-actinin, gamma-filamin, TCAP/telethonin, LDB3/ZASP and localizing calcineurin signaling to the sarcomere. Plays an important role in the modulation of calcineurin signaling. May play a role in myofibrillogenesis.

    GO - Molecular functioni

    1. FATZ binding Source: UniProtKB
    2. protein binding Source: UniProtKB

    GO - Biological processi

    1. myofibril assembly Source: UniProtKB

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Myozenin-1
    Alternative name(s):
    Calsarcin-2
    Filamin-, actinin- and telethonin-binding protein
    Protein FATZ
    Gene namesi
    Name:MYOZ1Imported
    Synonyms:MYOZImported
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 10

    Organism-specific databases

    HGNCiHGNC:13752. MYOZ1.

    Subcellular locationi

    Nucleus. Cell projectionpseudopodium
    Note: Localized to the nucleus and pseudopodia of undifferentiated cells and detected throughout the myotubes of differentiated cells. Colocalizes with ACTN2, FLNC and MYOT at the Z-lines of skeletal muscle.

    GO - Cellular componenti

    1. actin cytoskeleton Source: Ensembl
    2. nucleus Source: UniProtKB-SubCell
    3. pseudopodium Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell projection, Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA31420.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 299299Myozenin-1PRO_0000111095Add
    BLAST

    Proteomic databases

    PaxDbiQ9NP98.
    PRIDEiQ9NP98.

    PTM databases

    PhosphoSiteiQ9NP98.

    Expressioni

    Tissue specificityi

    Expressed primarily in skeletal muscle. Detected at lower levels in heart, prostate and pancreas.3 Publications

    Gene expression databases

    BgeeiQ9NP98.
    CleanExiHS_MYOZ1.
    GenevestigatoriQ9NP98.

    Organism-specific databases

    HPAiHPA037848.

    Interactioni

    Subunit structurei

    Interacts with ACTN2, ACTN3, FLNA, FLNB, FLNC, LDB3, PPP3CA and TCAP. Interacts via its C-terminal region with MYOT.5 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    TRIM63Q969Q12EBI-744402,EBI-5661333

    Protein-protein interaction databases

    BioGridi121849. 13 interactions.
    IntActiQ9NP98. 6 interactions.
    MINTiMINT-145528.
    STRINGi9606.ENSP00000352272.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9NP98.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi95 – 17581Gly-richSequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Belongs to the myozenin family.Curated

    Phylogenomic databases

    eggNOGiNOG79996.
    HOGENOMiHOG000030910.
    HOVERGENiHBG071289.
    InParanoidiQ9NP98.
    OMAiMPKFDLG.
    OrthoDBiEOG7B31NQ.
    PhylomeDBiQ9NP98.
    TreeFamiTF331748.

    Family and domain databases

    InterProiIPR008438. MYOZ.
    [Graphical view]
    PANTHERiPTHR15941. PTHR15941. 1 hit.
    PfamiPF05556. Calsarcin. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9NP98-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPLSGTPAPN KKRKSSKLIM ELTGGGQESS GLNLGKKISV PRDVMLEELS    50
    LLTNRGSKMF KLRQMRVEKF IYENHPDVFS DSSMDHFQKF LPTVGGQLGT 100
    AGQGFSYSKS NGRGGSQAGG SGSAGQYGSD QQHHLGSGSG AGGTGGPAGQ 150
    AGRGGAAGTA GVGETGSGDQ AGGEGKHITV FKTYISPWER AMGVDPQQKM 200
    ELGIDLLAYG AKAELPKYKS FNRTAMPYGG YEKASKRMTF QMPKFDLGPL 250
    LSEPLVLYNQ NLSNRPSFNR TPIPWLSSGE PVDYNVDIGI PLDGETEEL 299
    Length:299
    Mass (Da):31,745
    Last modified:October 1, 2000 - v1
    Checksum:iAADEB488C66B5E27
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti153 – 1531R → K in AAG38940. (PubMed:11114196)Curated
    Sequence conflicti160 – 1601A → T in AAG38940. (PubMed:11114196)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ278124 mRNA. Translation: CAB92967.1.
    AY013297 mRNA. Translation: AAG38940.1.
    AF240633 mRNA. Translation: AAG24509.1.
    AF243390
    , AF243387, AF243388, AF243389 Genomic DNA. Translation: AAG27296.1.
    AL359210 mRNA. Translation: CAB94568.1.
    BC025753 mRNA. Translation: AAH25753.1.
    CCDSiCCDS7330.1.
    RefSeqiNP_067068.1. NM_021245.3.
    UniGeneiHs.238756.

    Genome annotation databases

    EnsembliENST00000359322; ENSP00000352272; ENSG00000177791.
    GeneIDi58529.
    KEGGihsa:58529.
    UCSCiuc001jur.4. human.

    Polymorphism databases

    DMDMi74734300.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ278124 mRNA. Translation: CAB92967.1 .
    AY013297 mRNA. Translation: AAG38940.1 .
    AF240633 mRNA. Translation: AAG24509.1 .
    AF243390
    , AF243387 , AF243388 , AF243389 Genomic DNA. Translation: AAG27296.1 .
    AL359210 mRNA. Translation: CAB94568.1 .
    BC025753 mRNA. Translation: AAH25753.1 .
    CCDSi CCDS7330.1.
    RefSeqi NP_067068.1. NM_021245.3.
    UniGenei Hs.238756.

    3D structure databases

    ProteinModelPortali Q9NP98.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 121849. 13 interactions.
    IntActi Q9NP98. 6 interactions.
    MINTi MINT-145528.
    STRINGi 9606.ENSP00000352272.

    PTM databases

    PhosphoSitei Q9NP98.

    Polymorphism databases

    DMDMi 74734300.

    Proteomic databases

    PaxDbi Q9NP98.
    PRIDEi Q9NP98.

    Protocols and materials databases

    DNASUi 58529.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000359322 ; ENSP00000352272 ; ENSG00000177791 .
    GeneIDi 58529.
    KEGGi hsa:58529.
    UCSCi uc001jur.4. human.

    Organism-specific databases

    CTDi 58529.
    GeneCardsi GC10M075391.
    HGNCi HGNC:13752. MYOZ1.
    HPAi HPA037848.
    MIMi 605603. gene.
    neXtProti NX_Q9NP98.
    PharmGKBi PA31420.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG79996.
    HOGENOMi HOG000030910.
    HOVERGENi HBG071289.
    InParanoidi Q9NP98.
    OMAi MPKFDLG.
    OrthoDBi EOG7B31NQ.
    PhylomeDBi Q9NP98.
    TreeFami TF331748.

    Miscellaneous databases

    GeneWikii MYOZ1.
    GenomeRNAii 58529.
    NextBioi 65102.
    PROi Q9NP98.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9NP98.
    CleanExi HS_MYOZ1.
    Genevestigatori Q9NP98.

    Family and domain databases

    InterProi IPR008438. MYOZ.
    [Graphical view ]
    PANTHERi PTHR15941. PTHR15941. 1 hit.
    Pfami PF05556. Calsarcin. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA], INTERACTION WITH ACTN2; FLNC AND TCAP, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
      Tissue: Skeletal muscleImported.
    2. "Calsarcins, a novel family of sarcomeric calcineurin-binding proteins."
      Frey N., Richardson J.A., Olson E.N.
      Proc. Natl. Acad. Sci. U.S.A. 97:14632-14637(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], INTERACTION WITH ACTN2 AND PPP3CA, TISSUE SPECIFICITY.
      Tissue: Heart1 Publication.
    3. "Myozenin: an alpha-actinin- and gamma-filamin-binding protein of skeletal muscle Z lines."
      Takada F., Vander Woude D.L., Tong H.-Q., Thompson T.G., Watkins S.C., Kunkel L.M., Beggs A.H.
      Proc. Natl. Acad. Sci. U.S.A. 98:1595-1600(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], INTERACTION WITH ACTN2; ACTN3 AND FLNC, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
      Tissue: Skeletal muscleImported.
    4. The European IMAGE consortium
      Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: LungImported.
    6. "Calsarcin-3, a novel skeletal muscle-specific member of the calsarcin family, interacts with multiple Z-disc proteins."
      Frey N., Olson E.N.
      J. Biol. Chem. 277:13998-14004(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH LDB3.
    7. "The Z-disc proteins myotilin and FATZ-1 interact with each other and are connected to the sarcolemma via muscle-specific filamins."
      Gontier Y., Taivainen A., Fontao L., Sonnenberg A., van der Flier A., Carpen O., Faulkner G., Borradori L.
      J. Cell Sci. 118:3739-3749(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH FLNA; FLNB; FLNC AND MYOT, SUBCELLULAR LOCATION.

    Entry informationi

    Entry nameiMYOZ1_HUMAN
    AccessioniPrimary (citable) accession number: Q9NP98
    Secondary accession number(s): Q9H1I7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 22, 2005
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 97 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 10
      Human chromosome 10: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3