Q9NP95 (FGF20_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Fibroblast growth factor 20
Short name=FGF-20

Gene names

Name:

FGF20

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	211 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Neurotrophic factor that regulates central nervous development and function. Ref.7
Subunit structure	Homodimer. Interacts with FGFR2 and FGFR4. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by heparan sulfate glycosaminoglycans that function as coreceptors. Ref.7 Ref.9
Subcellular location	Secreted Ref.3.
Tissue specificity	Predominantly expressed in the cerebellum. Ref.3
Sequence similarities	Belongs to the heparin-binding growth factors family.

Ontologies

Keywords
Cellular component	Secreted
Coding sequence diversity	Polymorphism
Molecular function	Growth factor
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cell-cell signaling Traceable author statement Ref.1. Source: ProtInc fibroblast growth factor receptor signaling pathway Traceable author statement. Source: Reactome inner ear receptor cell differentiation Inferred from electronic annotation. Source: Compara insulin receptor signaling pathway Traceable author statement. Source: Reactome positive regulation of ERK1 and ERK2 cascade Inferred from electronic annotation. Source: Compara positive regulation of cell proliferation Inferred from electronic annotation. Source: Compara regulation of cardiac muscle cell proliferation Inferred from electronic annotation. Source: Compara
Cellular_component	extracellular region Traceable author statement. Source: Reactome
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 211

211

Fibroblast growth factor 20

PRO_0000147616

Natural variations

Natural variant

116

1

G → R. Ref.4
Corresponds to variant rs3793405 [ dbSNP | Ensembl ].

VAR_020946

Natural variant

175

1

P → A. Ref.4
Corresponds to variant rs10089600 [ dbSNP | Ensembl ].

VAR_020947

Natural variant

206

1

D → N. Ref.4
Corresponds to variant rs17550360 [ dbSNP | Ensembl ].

VAR_020948

Secondary structure

1

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

211

Helix Strand Turn

Details...

Helix

56 – 64

9

Beta strand

66 – 71

6

Turn

72 – 74

3

Beta strand

75 – 79

5

Beta strand

85 – 89

5

Beta strand

94 – 104

11

Beta strand

107 – 112

6

Turn

113 – 115

3

Beta strand

118 – 121

4

Beta strand

127 – 132

6

Helix

135 – 137

3

Beta strand

139 – 145

7

Beta strand

148 – 157

10

Turn

159 – 161

3

Beta strand

164 – 166

3

Beta strand

173 – 175

3

Helix

178 – 180

3

Helix

186 – 188

3

Beta strand

190 – 193

4

Helix

197 – 199

3

Helix

201 – 203

3

Sequences

	Sequence		Length	Mass (Da)
	Q9NP95 [UniParc]. Last modified October 1, 2000. Version 1. Checksum: AB04608C16060CC1	FASTA	211	23,499
	10 20 30 40 50 60 MAPLAEVGGF LGGLEGLGQQ VGSHFLLPPA GERPPLLGER RSAAERSARG GPGAAQLAHL 70 80 90 100 110 120 HGILRRRQLY CRTGFHLQIL PDGSVQGTRQ DHSLFGILEF ISVAVGLVSI RGVDSGLYLG 130 140 150 160 170 180 MNDKGELYGS EKLTSECIFR EQFEENWYNT YSSNIYKHGD TGRRYFVALN KDGTPRDGAR 190 200 210 SKRHQKFTHF LPRPVDPERV PELYKDLLMY T

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular cloning and characterization of human FGF-20 on chromosome 8p21.3-p22." Kirikoshi H., Sagara N., Saitoh T., Tanaka K., Sekihara H., Shiokawa K., Katoh M. Biochem. Biophys. Res. Commun. 274:337-343(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"FGF-20, a novel neurotrophic factor, preferentially expressed in the substantia nigra pars compacta of rat brain." Ohmachi S., Watanabe Y., Mikami T., Kusu N., Ibi T., Akaike A., Itoh N. Biochem. Biophys. Res. Commun. 277:355-360(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Brain.
[3]	"Identification of a novel human fibroblast growth factor and characterization of its role in oncogenesis." Jeffers M., Shimkets R., Prayaga S., Boldog F., Yang M., Burgess C., Fernandes E., Rittman B., Shimkets J., LaRochelle W.J., Lichenstein H.S. Cancer Res. 61:3131-3138(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
[4]	NIEHS SNPs program Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS ARG-116; ALA-175 AND ASN-206.
[5]	Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
[7]	"Receptor specificity of the fibroblast growth factor family. The complete mammalian FGF family." Zhang X., Ibrahimi O.A., Olsen S.K., Umemori H., Mohammadi M., Ornitz D.M. J. Biol. Chem. 281:15694-15700(2006) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH FGFR2 AND FGFR4, FUNCTION IN STIMULATION OF CELL PROLIFERATION.
[8]	"Fibroblast growth factor signalling: from development to cancer." Turner N., Grose R. Nat. Rev. Cancer 10:116-129(2010) [PubMed] [Europe PMC] [Abstract] Cited for: REVIEW.
[9]	"Homodimerization controls the fibroblast growth factor 9 subfamily's receptor binding and heparan sulfate-dependent diffusion in the extracellular matrix." Kalinina J., Byron S.A., Makarenkova H.P., Olsen S.K., Eliseenkova A.V., Larochelle W.J., Dhanabal M., Blais S., Ornitz D.M., Day L.A., Neubert T.A., Pollock P.M., Mohammadi M. Mol. Cell. Biol. 29:4663-4678(2009) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS), SUBUNIT, HEPARIN-BINDING.
+	Additional computationally mapped references.

Web resources

NIEHS-SNPs

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AB044277 mRNA. Translation: BAB03633.1.
AB030648 mRNA. Translation: BAB03530.1.
AY696296 Genomic DNA. Translation: AAT85804.1.
CH471080 Genomic DNA. Translation: EAW63828.1.
BC137446 mRNA. Translation: AAI37447.1.
BC137447 mRNA. Translation: AAI37448.1.

IPI

IPI00014608.

PIR

JC7353.

RefSeq

NP_062825.1. NM_019851.2.

UniGene

Hs.199905.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
3F1R	X-ray	2.50	A/B	1-211	[»]

ProteinModelPortal

Q9NP95.

ModBase

Search...

Protein-protein interaction databases

STRING

9606.ENSP00000180166.

PTM databases

PhosphoSite

Q9NP95.

Polymorphism databases

DMDM

13626702.

Proteomic databases

PaxDb

Q9NP95.

PRIDE

Q9NP95.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000180166; ENSP00000180166; ENSG00000078579.

GeneID

26281.

KEGG

hsa:26281.

UCSC

uc003wxc.1. human.

Organism-specific databases

CTD

26281.

GeneCards

GC08M016894.

HGNC

HGNC:3677. FGF20.

MIM

605558. gene.

neXtProt

NX_Q9NP95.

PharmGKB

PA28116.

GenAtlas

Search...

Phylogenomic databases

eggNOG

NOG269410.

HOGENOM

HOG000236341.

HOVERGEN

HBG007580.

InParanoid

Q9NP95.

KO

K04358.

OMA

YKDILMY.

OrthoDB

EOG46WZ9V.

PhylomeDB

Q9NP95.

Enzyme and pathway databases

Reactome

REACT_111102. Signal Transduction.
REACT_116125. Disease.
REACT_6900. Immune System.

Gene expression databases

ArrayExpress

Q9NP95.

Bgee

Q9NP95.

CleanEx

HS_FGF20.

Genevestigator

Q9NP95.

GermOnline

ENSG00000078579. Homo sapiens.

Family and domain databases

InterPro

IPR008996. Cytokine_IL1-like.
IPR002209. GF_heparin-bd.
IPR002348. IL1_HBGF.
[Graphical view]

PANTHER

PTHR11486. PTHR11486. 1 hit.

Pfam

PF00167. FGF. 1 hit.
[Graphical view]

PRINTS

PR00263. HBGFFGF.
PR00262. IL1HBGF.

SMART

SM00442. FGF. 1 hit.
[Graphical view]

SUPFAM

SSF50353. Cytok_IL1_like. 1 hit.

PROSITE

PS00247. HBGF_FGF. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

EvolutionaryTrace

Q9NP95.

GenomeRNAi

26281.

NextBio

48605.

SOURCE

Search...

Entry information

Entry name

FGF20_HUMAN

Accession

Primary (citable) accession number: Q9NP95
Secondary accession number(s): B2RPH5

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 27, 2001
Last sequence update:	October 1, 2000
Last modified:	May 1, 2013
This is version 98 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.