Reviewed, UniProtKB/Swiss-Prot Q9NP95 (FGF20_HUMAN)

Names and origin

Protein names

Recommended name:
    Fibroblast growth factor 20
      Short name=FGF-20

Gene names

Name:

FGF20

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	211 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Neurotrophic factor that regulates central nervous development and function.
Subcellular location	Secreted. Ref.3
Tissue specificity	Predominantly expressed in the cerebellum. Ref.3
Sequence similarities	Belongs to the heparin-binding growth factors family.

Ontologies

Keywords
Cellular component	Secreted
Coding sequence diversity	Polymorphism
Molecular function	Growth factor
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	cell growth Inferred from mutant phenotype. Source: UniProtKB cell-cell signaling Ref.1 Traceable author statement. Source: ProtInc fibroblast growth factor receptor signaling pathway Inferred from Experiment. Source: Reactome
Cellular component	extracellular region Ref.1 Inferred from Experiment. Source: Reactome soluble fraction Ref.1 Traceable author statement. Source: ProtInc
Molecular function	growth factor activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 211	211	Fibroblast growth factor 20		PRO_0000147616
Natural variations
	Natural variant	116	1	G → R: dbSNP rs3793405. Ref.4		VAR_020946
	Natural variant	175	1	P → A: dbSNP rs10089600. Ref.4		VAR_020947
	Natural variant	206	1	D → N: dbSNP rs17550360. Ref.4		VAR_020948

Sequences

	Sequence		Length	Mass (Da)
	Q9NP95-1 [UniParc]. Last modified October 1, 2000. Version 1. Checksum: AB04608C16060CC1	FASTA	211	23,499
	10 20 30 40 50 60 MAPLAEVGGF LGGLEGLGQQ VGSHFLLPPA GERPPLLGER RSAAERSARG GPGAAQLAHL 70 80 90 100 110 120 HGILRRRQLY CRTGFHLQIL PDGSVQGTRQ DHSLFGILEF ISVAVGLVSI RGVDSGLYLG 130 140 150 160 170 180 MNDKGELYGS EKLTSECIFR EQFEENWYNT YSSNIYKHGD TGRRYFVALN KDGTPRDGAR 190 200 210 SKRHQKFTHF LPRPVDPERV PELYKDLLMY T

References

[1]	"Molecular cloning and characterization of human FGF-20 on chromosome 8p21.3-p22." Kirikoshi H., Sagara N., Saitoh T., Tanaka K., Sekihara H., Shiokawa K., Katoh M. Biochem. Biophys. Res. Commun. 274:337-343(2000) [PubMed: 10913340] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"FGF-20, a novel neurotrophic factor, preferentially expressed in the substantia nigra pars compacta of rat brain." Ohmachi S., Watanabe Y., Mikami T., Kusu N., Ibi T., Akaike A., Itoh N. Biochem. Biophys. Res. Commun. 277:355-360(2000) [PubMed: 11032730] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Brain.
[3]	"Identification of a novel human fibroblast growth factor and characterization of its role in oncogenesis." Jeffers M., Shimkets R., Prayaga S., Boldog F., Yang M., Burgess C., Fernandes E., Rittman B., Shimkets J., LaRochelle W.J., Lichenstein H.S. Cancer Res. 61:3131-3138(2001) [PubMed: 11306498] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
[4]	NIEHS SNPs program Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS ARG-116; ALA-175 AND ASN-206.
+	Additional computationally mapped references.

Web resources

NIEHS-SNPs

Cross-references

Sequence databases
EMBLGenBankDDBJ	AB044277 mRNA. Translation: BAB03633.1. AB030648 mRNA. Translation: BAB03530.1. AY696296 Genomic DNA. Translation: AAT85804.1.
IPI	IPI00014608.
PIR	JC7353.
RefSeq	NP_062825.1.
UniGene	Hs.199905
3D structure databases
HSSP	HSSP built from PDB template 1IHK based on UniProtKB P31371.
SMR	Q9NP95. Positions 57-208.
ModBase	Search...
Proteomic databases
PRIDE	Q9NP95.
Genome annotation databases
Ensembl	ENSG00000078579. Homo sapiens. [Contig view]
GeneID	26281.
KEGG	hsa:26281.
UCSC	uc003wxc.1. human.
Organism-specific databases
GeneCards	GC08M016894.
H-InvDB	HIX0034235.
HGNC	HGNC:3677. FGF20.
MIM	605558. gene.
PharmGKB	PA28116.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	Q9NP95.
HOVERGEN	Q9NP95.
OMA	Q9NP95. KDILMYS.
Enzyme and pathway databases
Reactome	REACT_9470. Signaling by FGFR.
Gene expression databases
ArrayExpress	Q9NP95.
Bgee	Q9NP95.
CleanEx	HS_FGF20.
GermOnline	ENSG00000078579. Homo sapiens.
Family and domain databases
InterPro	IPR002209. GF_heparin_bd. IPR002348. IL1_HBGF. [Graphical view]
PANTHER	PTHR11486. IL1_HBGF. 1 hit.
Pfam	PF00167. FGF. 1 hit. [Graphical view]
PRINTS	PR00263. HBGFFGF. PR00262. IL1HBGF.
ProDom	PD000831. IL1_HBGF. 1 hit. [Graphical view] [Entries sharing at least one domain]
SMART	SM00442. FGF. 1 hit. [Graphical view]
PROSITE	PS00247. HBGF_FGF. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	48605.
SOURCE	Search...

Entry information

Entry name

FGF20_HUMAN

Accession

Primary (citable) accession number: Q9NP95

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 27, 2001
Last sequence update:	October 1, 2000
Last modified:	July 7, 2009
This is version 63 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)