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Q9NP95 (FGF20_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 109. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Fibroblast growth factor 20

Short name=FGF-20
Gene names
Name:FGF20
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length211 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Neurotrophic factor that regulates central nervous development and function. Ref.7

Subunit structure

Homodimer. Interacts with FGFR2 and FGFR4. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by heparan sulfate glycosaminoglycans that function as coreceptors. Ref.7 Ref.9

Subcellular location

Secreted Ref.3.

Tissue specificity

Predominantly expressed in the cerebellum. Ref.3

Sequence similarities

Belongs to the heparin-binding growth factors family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 211211Fibroblast growth factor 20
PRO_0000147616

Natural variations

Natural variant1161G → R. Ref.4
Corresponds to variant rs3793405 [ dbSNP | Ensembl ].
VAR_020946
Natural variant1751P → A. Ref.4
Corresponds to variant rs10089600 [ dbSNP | Ensembl ].
VAR_020947
Natural variant2061D → N. Ref.4
Corresponds to variant rs17550360 [ dbSNP | Ensembl ].
VAR_020948

Secondary structure

........................................ 211
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Q9NP95 [UniParc].

Last modified October 1, 2000. Version 1.
Checksum: AB04608C16060CC1

FASTA21123,499
        10         20         30         40         50         60 
MAPLAEVGGF LGGLEGLGQQ VGSHFLLPPA GERPPLLGER RSAAERSARG GPGAAQLAHL 

        70         80         90        100        110        120 
HGILRRRQLY CRTGFHLQIL PDGSVQGTRQ DHSLFGILEF ISVAVGLVSI RGVDSGLYLG 

       130        140        150        160        170        180 
MNDKGELYGS EKLTSECIFR EQFEENWYNT YSSNIYKHGD TGRRYFVALN KDGTPRDGAR 

       190        200        210 
SKRHQKFTHF LPRPVDPERV PELYKDLLMY T 

« Hide

References

« Hide 'large scale' references
[1]"Molecular cloning and characterization of human FGF-20 on chromosome 8p21.3-p22."
Kirikoshi H., Sagara N., Saitoh T., Tanaka K., Sekihara H., Shiokawa K., Katoh M.
Biochem. Biophys. Res. Commun. 274:337-343(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"FGF-20, a novel neurotrophic factor, preferentially expressed in the substantia nigra pars compacta of rat brain."
Ohmachi S., Watanabe Y., Mikami T., Kusu N., Ibi T., Akaike A., Itoh N.
Biochem. Biophys. Res. Commun. 277:355-360(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Brain.
[3]"Identification of a novel human fibroblast growth factor and characterization of its role in oncogenesis."
Jeffers M., Shimkets R., Prayaga S., Boldog F., Yang M., Burgess C., Fernandes E., Rittman B., Shimkets J., LaRochelle W.J., Lichenstein H.S.
Cancer Res. 61:3131-3138(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
[4]NIEHS SNPs program
Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS ARG-116; ALA-175 AND ASN-206.
[5]Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
[7]"Receptor specificity of the fibroblast growth factor family. The complete mammalian FGF family."
Zhang X., Ibrahimi O.A., Olsen S.K., Umemori H., Mohammadi M., Ornitz D.M.
J. Biol. Chem. 281:15694-15700(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH FGFR2 AND FGFR4, FUNCTION IN STIMULATION OF CELL PROLIFERATION.
[8]"Fibroblast growth factor signalling: from development to cancer."
Turner N., Grose R.
Nat. Rev. Cancer 10:116-129(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: REVIEW.
[9]"Homodimerization controls the fibroblast growth factor 9 subfamily's receptor binding and heparan sulfate-dependent diffusion in the extracellular matrix."
Kalinina J., Byron S.A., Makarenkova H.P., Olsen S.K., Eliseenkova A.V., Larochelle W.J., Dhanabal M., Blais S., Ornitz D.M., Day L.A., Neubert T.A., Pollock P.M., Mohammadi M.
Mol. Cell. Biol. 29:4663-4678(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS), SUBUNIT, HEPARIN-BINDING.
+Additional computationally mapped references.

Web resources

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB044277 mRNA. Translation: BAB03633.1.
AB030648 mRNA. Translation: BAB03530.1.
AY696296 Genomic DNA. Translation: AAT85804.1.
CH471080 Genomic DNA. Translation: EAW63828.1.
BC137446 mRNA. Translation: AAI37447.1.
BC137447 mRNA. Translation: AAI37448.1.
CCDSCCDS5998.1.
PIRJC7353.
RefSeqNP_062825.1. NM_019851.2.
UniGeneHs.199905.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
3F1RX-ray2.50A/B1-211[»]
ProteinModelPortalQ9NP95.
SMRQ9NP95. Positions 52-208.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000180166.

PTM databases

PhosphoSiteQ9NP95.

Polymorphism databases

DMDM13626702.

Proteomic databases

PaxDbQ9NP95.
PRIDEQ9NP95.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000180166; ENSP00000180166; ENSG00000078579.
GeneID26281.
KEGGhsa:26281.
UCSCuc003wxc.1. human.

Organism-specific databases

CTD26281.
GeneCardsGC08M016894.
HGNCHGNC:3677. FGF20.
MIM605558. gene.
neXtProtNX_Q9NP95.
PharmGKBPA28116.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG269410.
HOGENOMHOG000236341.
HOVERGENHBG007580.
InParanoidQ9NP95.
KOK04358.
OMAYKDILMY.
OrthoDBEOG7992S1.
PhylomeDBQ9NP95.
TreeFamTF317805.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.
REACT_116125. Disease.
REACT_6900. Immune System.

Gene expression databases

BgeeQ9NP95.
CleanExHS_FGF20.
GenevestigatorQ9NP95.

Family and domain databases

InterProIPR008996. Cytokine_IL1-like.
IPR028291. FGF20.
IPR002209. Fibroblast_GF_fam.
IPR028142. IL-1_fam/FGF_fam.
[Graphical view]
PANTHERPTHR11486. PTHR11486. 1 hit.
PTHR11486:SF72. PTHR11486:SF72. 1 hit.
PfamPF00167. FGF. 1 hit.
[Graphical view]
PRINTSPR00263. HBGFFGF.
PR00262. IL1HBGF.
SMARTSM00442. FGF. 1 hit.
[Graphical view]
SUPFAMSSF50353. SSF50353. 1 hit.
PROSITEPS00247. HBGF_FGF. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceQ9NP95.
GenomeRNAi26281.
NextBio48605.
PROQ9NP95.
SOURCESearch...

Entry information

Entry nameFGF20_HUMAN
AccessionPrimary (citable) accession number: Q9NP95
Secondary accession number(s): B2RPH5
Entry history
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: October 1, 2000
Last modified: July 9, 2014
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 8

Human chromosome 8: entries, gene names and cross-references to MIM