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Q9NP95

- FGF20_HUMAN

UniProt

Q9NP95 - FGF20_HUMAN

Protein

Fibroblast growth factor 20

Gene

FGF20

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 111 (01 Oct 2014)
      Sequence version 1 (01 Oct 2000)
      Previous versions | rss
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    Functioni

    Neurotrophic factor that regulates central nervous development and function.1 Publication

    GO - Biological processi

    1. cell-cell signaling Source: ProtInc
    2. epidermal growth factor receptor signaling pathway Source: Reactome
    3. Fc-epsilon receptor signaling pathway Source: Reactome
    4. fibroblast growth factor receptor signaling pathway Source: Reactome
    5. innate immune response Source: Reactome
    6. inner ear receptor cell differentiation Source: Ensembl
    7. insulin receptor signaling pathway Source: Reactome
    8. neurotrophin TRK receptor signaling pathway Source: Reactome
    9. phosphatidylinositol-mediated signaling Source: Reactome
    10. positive regulation of cell proliferation Source: Ensembl
    11. positive regulation of ERK1 and ERK2 cascade Source: Ensembl
    12. regulation of cardiac muscle cell proliferation Source: Ensembl
    13. signal transduction Source: ProtInc

    Keywords - Molecular functioni

    Growth factor

    Enzyme and pathway databases

    ReactomeiREACT_111184. Negative regulation of FGFR signaling.
    REACT_120863. Activated point mutants of FGFR2.
    REACT_121153. Signaling by activated point mutants of FGFR1.
    REACT_121249. Signaling by FGFR3 mutants.
    REACT_121337. Signaling by activated point mutants of FGFR3.
    REACT_121398. Signaling by FGFR mutants.
    REACT_147727. Constitutive PI3K/AKT Signaling in Cancer.
    REACT_21247. FRS2-mediated cascade.
    REACT_21270. PI-3K cascade.
    REACT_21310. Phospholipase C-mediated cascade.
    REACT_21374. SHC-mediated cascade.
    REACT_75829. PIP3 activates AKT signaling.
    REACT_9413. FGFR2c ligand binding and activation.
    REACT_9452. FGFR4 ligand binding and activation.
    REACT_9508. FGFR3b ligand binding and activation.
    REACT_9510. FGFR3c ligand binding and activation.
    REACT_9515. FGFR1c ligand binding and activation.
    REACT_976. PI3K Cascade.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Fibroblast growth factor 20
    Short name:
    FGF-20
    Gene namesi
    Name:FGF20
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 8

    Organism-specific databases

    HGNCiHGNC:3677. FGF20.

    Subcellular locationi

    Secreted 1 Publication

    GO - Cellular componenti

    1. extracellular region Source: Reactome

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA28116.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 211211Fibroblast growth factor 20PRO_0000147616Add
    BLAST

    Proteomic databases

    PaxDbiQ9NP95.
    PRIDEiQ9NP95.

    PTM databases

    PhosphoSiteiQ9NP95.

    Expressioni

    Tissue specificityi

    Predominantly expressed in the cerebellum.1 Publication

    Gene expression databases

    BgeeiQ9NP95.
    CleanExiHS_FGF20.
    GenevestigatoriQ9NP95.

    Interactioni

    Subunit structurei

    Homodimer. Interacts with FGFR2 and FGFR4. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by heparan sulfate glycosaminoglycans that function as coreceptors.2 Publications

    Protein-protein interaction databases

    STRINGi9606.ENSP00000180166.

    Structurei

    Secondary structure

    1
    211
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi56 – 649
    Beta strandi66 – 716
    Turni72 – 743
    Beta strandi75 – 795
    Beta strandi85 – 895
    Beta strandi94 – 10411
    Beta strandi107 – 1126
    Turni113 – 1153
    Beta strandi118 – 1214
    Beta strandi127 – 1326
    Helixi135 – 1373
    Beta strandi139 – 1457
    Beta strandi148 – 15710
    Turni159 – 1613
    Beta strandi164 – 1663
    Beta strandi173 – 1753
    Helixi178 – 1803
    Helixi186 – 1883
    Beta strandi190 – 1934
    Helixi197 – 1993
    Helixi201 – 2033

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3F1RX-ray2.50A/B1-211[»]
    ProteinModelPortaliQ9NP95.
    SMRiQ9NP95. Positions 52-208.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ9NP95.

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiNOG269410.
    HOGENOMiHOG000236341.
    HOVERGENiHBG007580.
    InParanoidiQ9NP95.
    KOiK04358.
    OMAiYKDILMY.
    OrthoDBiEOG7992S1.
    PhylomeDBiQ9NP95.
    TreeFamiTF317805.

    Family and domain databases

    InterProiIPR008996. Cytokine_IL1-like.
    IPR028291. FGF20.
    IPR002209. Fibroblast_GF_fam.
    IPR028142. IL-1_fam/FGF_fam.
    [Graphical view]
    PANTHERiPTHR11486. PTHR11486. 1 hit.
    PTHR11486:SF72. PTHR11486:SF72. 1 hit.
    PfamiPF00167. FGF. 1 hit.
    [Graphical view]
    PRINTSiPR00263. HBGFFGF.
    PR00262. IL1HBGF.
    SMARTiSM00442. FGF. 1 hit.
    [Graphical view]
    SUPFAMiSSF50353. SSF50353. 1 hit.
    PROSITEiPS00247. HBGF_FGF. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9NP95-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAPLAEVGGF LGGLEGLGQQ VGSHFLLPPA GERPPLLGER RSAAERSARG    50
    GPGAAQLAHL HGILRRRQLY CRTGFHLQIL PDGSVQGTRQ DHSLFGILEF 100
    ISVAVGLVSI RGVDSGLYLG MNDKGELYGS EKLTSECIFR EQFEENWYNT 150
    YSSNIYKHGD TGRRYFVALN KDGTPRDGAR SKRHQKFTHF LPRPVDPERV 200
    PELYKDLLMY T 211
    Length:211
    Mass (Da):23,499
    Last modified:October 1, 2000 - v1
    Checksum:iAB04608C16060CC1
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti116 – 1161G → R.1 Publication
    Corresponds to variant rs3793405 [ dbSNP | Ensembl ].
    VAR_020946
    Natural varianti175 – 1751P → A.1 Publication
    Corresponds to variant rs10089600 [ dbSNP | Ensembl ].
    VAR_020947
    Natural varianti206 – 2061D → N.1 Publication
    Corresponds to variant rs17550360 [ dbSNP | Ensembl ].
    VAR_020948

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB044277 mRNA. Translation: BAB03633.1.
    AB030648 mRNA. Translation: BAB03530.1.
    AY696296 Genomic DNA. Translation: AAT85804.1.
    CH471080 Genomic DNA. Translation: EAW63828.1.
    BC137446 mRNA. Translation: AAI37447.1.
    BC137447 mRNA. Translation: AAI37448.1.
    CCDSiCCDS5998.1.
    PIRiJC7353.
    RefSeqiNP_062825.1. NM_019851.2.
    UniGeneiHs.199905.

    Genome annotation databases

    EnsembliENST00000180166; ENSP00000180166; ENSG00000078579.
    GeneIDi26281.
    KEGGihsa:26281.
    UCSCiuc003wxc.1. human.

    Polymorphism databases

    DMDMi13626702.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    NIEHS-SNPs

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB044277 mRNA. Translation: BAB03633.1 .
    AB030648 mRNA. Translation: BAB03530.1 .
    AY696296 Genomic DNA. Translation: AAT85804.1 .
    CH471080 Genomic DNA. Translation: EAW63828.1 .
    BC137446 mRNA. Translation: AAI37447.1 .
    BC137447 mRNA. Translation: AAI37448.1 .
    CCDSi CCDS5998.1.
    PIRi JC7353.
    RefSeqi NP_062825.1. NM_019851.2.
    UniGenei Hs.199905.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3F1R X-ray 2.50 A/B 1-211 [» ]
    ProteinModelPortali Q9NP95.
    SMRi Q9NP95. Positions 52-208.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000180166.

    PTM databases

    PhosphoSitei Q9NP95.

    Polymorphism databases

    DMDMi 13626702.

    Proteomic databases

    PaxDbi Q9NP95.
    PRIDEi Q9NP95.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000180166 ; ENSP00000180166 ; ENSG00000078579 .
    GeneIDi 26281.
    KEGGi hsa:26281.
    UCSCi uc003wxc.1. human.

    Organism-specific databases

    CTDi 26281.
    GeneCardsi GC08M016894.
    HGNCi HGNC:3677. FGF20.
    MIMi 605558. gene.
    neXtProti NX_Q9NP95.
    PharmGKBi PA28116.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG269410.
    HOGENOMi HOG000236341.
    HOVERGENi HBG007580.
    InParanoidi Q9NP95.
    KOi K04358.
    OMAi YKDILMY.
    OrthoDBi EOG7992S1.
    PhylomeDBi Q9NP95.
    TreeFami TF317805.

    Enzyme and pathway databases

    Reactomei REACT_111184. Negative regulation of FGFR signaling.
    REACT_120863. Activated point mutants of FGFR2.
    REACT_121153. Signaling by activated point mutants of FGFR1.
    REACT_121249. Signaling by FGFR3 mutants.
    REACT_121337. Signaling by activated point mutants of FGFR3.
    REACT_121398. Signaling by FGFR mutants.
    REACT_147727. Constitutive PI3K/AKT Signaling in Cancer.
    REACT_21247. FRS2-mediated cascade.
    REACT_21270. PI-3K cascade.
    REACT_21310. Phospholipase C-mediated cascade.
    REACT_21374. SHC-mediated cascade.
    REACT_75829. PIP3 activates AKT signaling.
    REACT_9413. FGFR2c ligand binding and activation.
    REACT_9452. FGFR4 ligand binding and activation.
    REACT_9508. FGFR3b ligand binding and activation.
    REACT_9510. FGFR3c ligand binding and activation.
    REACT_9515. FGFR1c ligand binding and activation.
    REACT_976. PI3K Cascade.

    Miscellaneous databases

    EvolutionaryTracei Q9NP95.
    GenomeRNAii 26281.
    NextBioi 48605.
    PROi Q9NP95.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9NP95.
    CleanExi HS_FGF20.
    Genevestigatori Q9NP95.

    Family and domain databases

    InterProi IPR008996. Cytokine_IL1-like.
    IPR028291. FGF20.
    IPR002209. Fibroblast_GF_fam.
    IPR028142. IL-1_fam/FGF_fam.
    [Graphical view ]
    PANTHERi PTHR11486. PTHR11486. 1 hit.
    PTHR11486:SF72. PTHR11486:SF72. 1 hit.
    Pfami PF00167. FGF. 1 hit.
    [Graphical view ]
    PRINTSi PR00263. HBGFFGF.
    PR00262. IL1HBGF.
    SMARTi SM00442. FGF. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50353. SSF50353. 1 hit.
    PROSITEi PS00247. HBGF_FGF. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning and characterization of human FGF-20 on chromosome 8p21.3-p22."
      Kirikoshi H., Sagara N., Saitoh T., Tanaka K., Sekihara H., Shiokawa K., Katoh M.
      Biochem. Biophys. Res. Commun. 274:337-343(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "FGF-20, a novel neurotrophic factor, preferentially expressed in the substantia nigra pars compacta of rat brain."
      Ohmachi S., Watanabe Y., Mikami T., Kusu N., Ibi T., Akaike A., Itoh N.
      Biochem. Biophys. Res. Commun. 277:355-360(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Brain.
    3. "Identification of a novel human fibroblast growth factor and characterization of its role in oncogenesis."
      Jeffers M., Shimkets R., Prayaga S., Boldog F., Yang M., Burgess C., Fernandes E., Rittman B., Shimkets J., LaRochelle W.J., Lichenstein H.S.
      Cancer Res. 61:3131-3138(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    4. NIEHS SNPs program
      Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS ARG-116; ALA-175 AND ASN-206.
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    7. "Receptor specificity of the fibroblast growth factor family. The complete mammalian FGF family."
      Zhang X., Ibrahimi O.A., Olsen S.K., Umemori H., Mohammadi M., Ornitz D.M.
      J. Biol. Chem. 281:15694-15700(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH FGFR2 AND FGFR4, FUNCTION IN STIMULATION OF CELL PROLIFERATION.
    8. "Fibroblast growth factor signalling: from development to cancer."
      Turner N., Grose R.
      Nat. Rev. Cancer 10:116-129(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: REVIEW.
    9. "Homodimerization controls the fibroblast growth factor 9 subfamily's receptor binding and heparan sulfate-dependent diffusion in the extracellular matrix."
      Kalinina J., Byron S.A., Makarenkova H.P., Olsen S.K., Eliseenkova A.V., Larochelle W.J., Dhanabal M., Blais S., Ornitz D.M., Day L.A., Neubert T.A., Pollock P.M., Mohammadi M.
      Mol. Cell. Biol. 29:4663-4678(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS), SUBUNIT, HEPARIN-BINDING.

    Entry informationi

    Entry nameiFGF20_HUMAN
    AccessioniPrimary (citable) accession number: Q9NP95
    Secondary accession number(s): B2RPH5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 27, 2001
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 111 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 8
      Human chromosome 8: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3