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Q9NP95

- FGF20_HUMAN

UniProt

Q9NP95 - FGF20_HUMAN

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Protein
Fibroblast growth factor 20
Gene
FGF20
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Neurotrophic factor that regulates central nervous development and function.1 Publication

GO - Biological processi

  1. Fc-epsilon receptor signaling pathway Source: Reactome
  2. cell-cell signaling Source: ProtInc
  3. epidermal growth factor receptor signaling pathway Source: Reactome
  4. fibroblast growth factor receptor signaling pathway Source: Reactome
  5. innate immune response Source: Reactome
  6. inner ear receptor cell differentiation Source: Ensembl
  7. insulin receptor signaling pathway Source: Reactome
  8. neurotrophin TRK receptor signaling pathway Source: Reactome
  9. phosphatidylinositol-mediated signaling Source: Reactome
  10. positive regulation of ERK1 and ERK2 cascade Source: Ensembl
  11. positive regulation of cell proliferation Source: Ensembl
  12. regulation of cardiac muscle cell proliferation Source: Ensembl
  13. signal transduction Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Growth factor

Enzyme and pathway databases

ReactomeiREACT_111184. Negative regulation of FGFR signaling.
REACT_120863. Activated point mutants of FGFR2.
REACT_121153. Signaling by activated point mutants of FGFR1.
REACT_121249. Signaling by FGFR3 mutants.
REACT_121337. Signaling by activated point mutants of FGFR3.
REACT_121398. Signaling by FGFR mutants.
REACT_147727. Constitutive PI3K/AKT Signaling in Cancer.
REACT_21247. FRS2-mediated cascade.
REACT_21270. PI-3K cascade.
REACT_21310. Phospholipase C-mediated cascade.
REACT_21374. SHC-mediated cascade.
REACT_75829. PIP3 activates AKT signaling.
REACT_9413. FGFR2c ligand binding and activation.
REACT_9452. FGFR4 ligand binding and activation.
REACT_9508. FGFR3b ligand binding and activation.
REACT_9510. FGFR3c ligand binding and activation.
REACT_9515. FGFR1c ligand binding and activation.
REACT_976. PI3K Cascade.

Names & Taxonomyi

Protein namesi
Recommended name:
Fibroblast growth factor 20
Short name:
FGF-20
Gene namesi
Name:FGF20
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 8

Organism-specific databases

HGNCiHGNC:3677. FGF20.

Subcellular locationi

Secreted 1 Publication

GO - Cellular componenti

  1. extracellular region Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA28116.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 211211Fibroblast growth factor 20
PRO_0000147616Add
BLAST

Proteomic databases

PaxDbiQ9NP95.
PRIDEiQ9NP95.

PTM databases

PhosphoSiteiQ9NP95.

Expressioni

Tissue specificityi

Predominantly expressed in the cerebellum.1 Publication

Gene expression databases

BgeeiQ9NP95.
CleanExiHS_FGF20.
GenevestigatoriQ9NP95.

Interactioni

Subunit structurei

Homodimer. Interacts with FGFR2 and FGFR4. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by heparan sulfate glycosaminoglycans that function as coreceptors.2 Publications

Protein-protein interaction databases

STRINGi9606.ENSP00000180166.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi56 – 649
Beta strandi66 – 716
Turni72 – 743
Beta strandi75 – 795
Beta strandi85 – 895
Beta strandi94 – 10411
Beta strandi107 – 1126
Turni113 – 1153
Beta strandi118 – 1214
Beta strandi127 – 1326
Helixi135 – 1373
Beta strandi139 – 1457
Beta strandi148 – 15710
Turni159 – 1613
Beta strandi164 – 1663
Beta strandi173 – 1753
Helixi178 – 1803
Helixi186 – 1883
Beta strandi190 – 1934
Helixi197 – 1993
Helixi201 – 2033

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3F1RX-ray2.50A/B1-211[»]
ProteinModelPortaliQ9NP95.
SMRiQ9NP95. Positions 52-208.

Miscellaneous databases

EvolutionaryTraceiQ9NP95.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiNOG269410.
HOGENOMiHOG000236341.
HOVERGENiHBG007580.
InParanoidiQ9NP95.
KOiK04358.
OMAiYKDILMY.
OrthoDBiEOG7992S1.
PhylomeDBiQ9NP95.
TreeFamiTF317805.

Family and domain databases

InterProiIPR008996. Cytokine_IL1-like.
IPR028291. FGF20.
IPR002209. Fibroblast_GF_fam.
IPR028142. IL-1_fam/FGF_fam.
[Graphical view]
PANTHERiPTHR11486. PTHR11486. 1 hit.
PTHR11486:SF72. PTHR11486:SF72. 1 hit.
PfamiPF00167. FGF. 1 hit.
[Graphical view]
PRINTSiPR00263. HBGFFGF.
PR00262. IL1HBGF.
SMARTiSM00442. FGF. 1 hit.
[Graphical view]
SUPFAMiSSF50353. SSF50353. 1 hit.
PROSITEiPS00247. HBGF_FGF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9NP95-1 [UniParc]FASTAAdd to Basket

« Hide

MAPLAEVGGF LGGLEGLGQQ VGSHFLLPPA GERPPLLGER RSAAERSARG    50
GPGAAQLAHL HGILRRRQLY CRTGFHLQIL PDGSVQGTRQ DHSLFGILEF 100
ISVAVGLVSI RGVDSGLYLG MNDKGELYGS EKLTSECIFR EQFEENWYNT 150
YSSNIYKHGD TGRRYFVALN KDGTPRDGAR SKRHQKFTHF LPRPVDPERV 200
PELYKDLLMY T 211
Length:211
Mass (Da):23,499
Last modified:October 1, 2000 - v1
Checksum:iAB04608C16060CC1
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti116 – 1161G → R.1 Publication
Corresponds to variant rs3793405 [ dbSNP | Ensembl ].
VAR_020946
Natural varianti175 – 1751P → A.1 Publication
Corresponds to variant rs10089600 [ dbSNP | Ensembl ].
VAR_020947
Natural varianti206 – 2061D → N.1 Publication
Corresponds to variant rs17550360 [ dbSNP | Ensembl ].
VAR_020948

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB044277 mRNA. Translation: BAB03633.1.
AB030648 mRNA. Translation: BAB03530.1.
AY696296 Genomic DNA. Translation: AAT85804.1.
CH471080 Genomic DNA. Translation: EAW63828.1.
BC137446 mRNA. Translation: AAI37447.1.
BC137447 mRNA. Translation: AAI37448.1.
CCDSiCCDS5998.1.
PIRiJC7353.
RefSeqiNP_062825.1. NM_019851.2.
UniGeneiHs.199905.

Genome annotation databases

EnsembliENST00000180166; ENSP00000180166; ENSG00000078579.
GeneIDi26281.
KEGGihsa:26281.
UCSCiuc003wxc.1. human.

Polymorphism databases

DMDMi13626702.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB044277 mRNA. Translation: BAB03633.1 .
AB030648 mRNA. Translation: BAB03530.1 .
AY696296 Genomic DNA. Translation: AAT85804.1 .
CH471080 Genomic DNA. Translation: EAW63828.1 .
BC137446 mRNA. Translation: AAI37447.1 .
BC137447 mRNA. Translation: AAI37448.1 .
CCDSi CCDS5998.1.
PIRi JC7353.
RefSeqi NP_062825.1. NM_019851.2.
UniGenei Hs.199905.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3F1R X-ray 2.50 A/B 1-211 [» ]
ProteinModelPortali Q9NP95.
SMRi Q9NP95. Positions 52-208.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000180166.

PTM databases

PhosphoSitei Q9NP95.

Polymorphism databases

DMDMi 13626702.

Proteomic databases

PaxDbi Q9NP95.
PRIDEi Q9NP95.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000180166 ; ENSP00000180166 ; ENSG00000078579 .
GeneIDi 26281.
KEGGi hsa:26281.
UCSCi uc003wxc.1. human.

Organism-specific databases

CTDi 26281.
GeneCardsi GC08M016894.
HGNCi HGNC:3677. FGF20.
MIMi 605558. gene.
neXtProti NX_Q9NP95.
PharmGKBi PA28116.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG269410.
HOGENOMi HOG000236341.
HOVERGENi HBG007580.
InParanoidi Q9NP95.
KOi K04358.
OMAi YKDILMY.
OrthoDBi EOG7992S1.
PhylomeDBi Q9NP95.
TreeFami TF317805.

Enzyme and pathway databases

Reactomei REACT_111184. Negative regulation of FGFR signaling.
REACT_120863. Activated point mutants of FGFR2.
REACT_121153. Signaling by activated point mutants of FGFR1.
REACT_121249. Signaling by FGFR3 mutants.
REACT_121337. Signaling by activated point mutants of FGFR3.
REACT_121398. Signaling by FGFR mutants.
REACT_147727. Constitutive PI3K/AKT Signaling in Cancer.
REACT_21247. FRS2-mediated cascade.
REACT_21270. PI-3K cascade.
REACT_21310. Phospholipase C-mediated cascade.
REACT_21374. SHC-mediated cascade.
REACT_75829. PIP3 activates AKT signaling.
REACT_9413. FGFR2c ligand binding and activation.
REACT_9452. FGFR4 ligand binding and activation.
REACT_9508. FGFR3b ligand binding and activation.
REACT_9510. FGFR3c ligand binding and activation.
REACT_9515. FGFR1c ligand binding and activation.
REACT_976. PI3K Cascade.

Miscellaneous databases

EvolutionaryTracei Q9NP95.
GenomeRNAii 26281.
NextBioi 48605.
PROi Q9NP95.
SOURCEi Search...

Gene expression databases

Bgeei Q9NP95.
CleanExi HS_FGF20.
Genevestigatori Q9NP95.

Family and domain databases

InterProi IPR008996. Cytokine_IL1-like.
IPR028291. FGF20.
IPR002209. Fibroblast_GF_fam.
IPR028142. IL-1_fam/FGF_fam.
[Graphical view ]
PANTHERi PTHR11486. PTHR11486. 1 hit.
PTHR11486:SF72. PTHR11486:SF72. 1 hit.
Pfami PF00167. FGF. 1 hit.
[Graphical view ]
PRINTSi PR00263. HBGFFGF.
PR00262. IL1HBGF.
SMARTi SM00442. FGF. 1 hit.
[Graphical view ]
SUPFAMi SSF50353. SSF50353. 1 hit.
PROSITEi PS00247. HBGF_FGF. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning and characterization of human FGF-20 on chromosome 8p21.3-p22."
    Kirikoshi H., Sagara N., Saitoh T., Tanaka K., Sekihara H., Shiokawa K., Katoh M.
    Biochem. Biophys. Res. Commun. 274:337-343(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "FGF-20, a novel neurotrophic factor, preferentially expressed in the substantia nigra pars compacta of rat brain."
    Ohmachi S., Watanabe Y., Mikami T., Kusu N., Ibi T., Akaike A., Itoh N.
    Biochem. Biophys. Res. Commun. 277:355-360(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.
  3. "Identification of a novel human fibroblast growth factor and characterization of its role in oncogenesis."
    Jeffers M., Shimkets R., Prayaga S., Boldog F., Yang M., Burgess C., Fernandes E., Rittman B., Shimkets J., LaRochelle W.J., Lichenstein H.S.
    Cancer Res. 61:3131-3138(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  4. NIEHS SNPs program
    Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS ARG-116; ALA-175 AND ASN-206.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  7. "Receptor specificity of the fibroblast growth factor family. The complete mammalian FGF family."
    Zhang X., Ibrahimi O.A., Olsen S.K., Umemori H., Mohammadi M., Ornitz D.M.
    J. Biol. Chem. 281:15694-15700(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH FGFR2 AND FGFR4, FUNCTION IN STIMULATION OF CELL PROLIFERATION.
  8. "Fibroblast growth factor signalling: from development to cancer."
    Turner N., Grose R.
    Nat. Rev. Cancer 10:116-129(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.
  9. "Homodimerization controls the fibroblast growth factor 9 subfamily's receptor binding and heparan sulfate-dependent diffusion in the extracellular matrix."
    Kalinina J., Byron S.A., Makarenkova H.P., Olsen S.K., Eliseenkova A.V., Larochelle W.J., Dhanabal M., Blais S., Ornitz D.M., Day L.A., Neubert T.A., Pollock P.M., Mohammadi M.
    Mol. Cell. Biol. 29:4663-4678(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS), SUBUNIT, HEPARIN-BINDING.

Entry informationi

Entry nameiFGF20_HUMAN
AccessioniPrimary (citable) accession number: Q9NP95
Secondary accession number(s): B2RPH5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: October 1, 2000
Last modified: September 3, 2014
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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