Fibroblast growth factor 20 - Homo sapiens (Human)

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Reviewed, UniProtKB/Swiss-Prot Q9NP95 (FGF20_HUMAN)

Last modified January 19, 2010. Version 71. History...

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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Web resources · Cross-references · Entry information · Relevant documents

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Names and origin

Protein names

Recommended name:
Fibroblast growth factor 20
Short name=FGF-20

Gene names

Name:

FGF20

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

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Protein attributes

Sequence length	211 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level.

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General annotation (Comments)

Function	Neurotrophic factor that regulates central nervous development and function.
Subcellular location	Secreted Ref.3.
Tissue specificity	Predominantly expressed in the cerebellum. Ref.3
Sequence similarities	Belongs to the heparin-binding growth factors family.

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Ontologies

Keywords
Cellular component	Secreted
Coding sequence diversity	Polymorphism
Molecular function	Growth factor
Technical term	3D-structure Complete proteome
Gene Ontology (GO)
Biological process	cell growth Inferred from mutant phenotype. Source: UniProtKB cell-cell signaling Ref.1 Traceable author statement. Source: ProtInc fibroblast growth factor receptor signaling pathway Inferred from Experiment. Source: Reactome
Cellular component	extracellular region Ref.1 Inferred from Experiment. Source: Reactome soluble fraction Ref.1 Traceable author statement. Source: ProtInc
Molecular function	growth factor activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

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Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 211

211

Fibroblast growth factor 20

PRO_0000147616

Natural variations

Natural variant

116

G → R: dbSNP rs3793405. Ref.4

VAR_020946

Natural variant

175

P → A: dbSNP rs10089600. Ref.4

VAR_020947

Natural variant

206

D → N: dbSNP rs17550360. Ref.4

VAR_020948

Secondary structure

211

Helix Strand Turn

Details...

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Sequences

Sequence

Length

Mass (Da)

Tools

Q9NP95-1 [UniParc].

Last modified October 1, 2000. Version 1.
Checksum: AB04608C16060CC1
Show »

FASTA

211

23,499

        10         20         30         40         50         60 
MAPLAEVGGF LGGLEGLGQQ VGSHFLLPPA GERPPLLGER RSAAERSARG GPGAAQLAHL 

        70         80         90        100        110        120 
HGILRRRQLY CRTGFHLQIL PDGSVQGTRQ DHSLFGILEF ISVAVGLVSI RGVDSGLYLG 

       130        140        150        160        170        180 
MNDKGELYGS EKLTSECIFR EQFEENWYNT YSSNIYKHGD TGRRYFVALN KDGTPRDGAR 

       190        200        210 
SKRHQKFTHF LPRPVDPERV PELYKDLLMY T

« Hide

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References

[1]	"Molecular cloning and characterization of human FGF-20 on chromosome 8p21.3-p22." Kirikoshi H., Sagara N., Saitoh T., Tanaka K., Sekihara H., Shiokawa K., Katoh M. Biochem. Biophys. Res. Commun. 274:337-343(2000) [PubMed: 10913340] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"FGF-20, a novel neurotrophic factor, preferentially expressed in the substantia nigra pars compacta of rat brain." Ohmachi S., Watanabe Y., Mikami T., Kusu N., Ibi T., Akaike A., Itoh N. Biochem. Biophys. Res. Commun. 277:355-360(2000) [PubMed: 11032730] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Brain.
[3]	"Identification of a novel human fibroblast growth factor and characterization of its role in oncogenesis." Jeffers M., Shimkets R., Prayaga S., Boldog F., Yang M., Burgess C., Fernandes E., Rittman B., Shimkets J., LaRochelle W.J., Lichenstein H.S. Cancer Res. 61:3131-3138(2001) [PubMed: 11306498] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
[4]	NIEHS SNPs program Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS ARG-116; ALA-175 AND ASN-206.
+	Additional computationally mapped references.

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Web resources

NIEHS-SNPs

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AB044277 mRNA. Translation: BAB03633.1.
AB030648 mRNA. Translation: BAB03530.1.
AY696296 Genomic DNA. Translation: AAT85804.1.

IPI

IPI00014608.

PIR

JC7353.

RefSeq

NP_062825.1.

UniGene

Hs.199905

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
3F1R	X-ray	2.50	A/B	1-211	[»]

ModBase

Search...

Protein-protein interaction databases

STRING

Q9NP95.

Proteomic databases

PRIDE

Q9NP95.

Genome annotation databases

Ensembl

ENST00000180166; ENSP00000180166; ENSG00000078579; Homo sapiens. [Genome view]

GeneID

26281.

KEGG

hsa:26281.

UCSC

uc003wxc.1. human.

Organism-specific databases

CTD

26281.

GeneCards

GC08M016894.

H-InvDB

HIX0034235.

HGNC

HGNC:3677. FGF20.

MIM

605558. gene.

PharmGKB

PA28116.

GenAtlas

Search...

Phylogenomic databases

HOGENOM

HBG715603.

HOVERGEN

Q9NP95.

InParanoid

Q9NP95.

OMA

KDILMYS.

OrthoDB

EOG9N5ZG3.

PhylomeDB

Q9NP95.

Enzyme and pathway databases

Reactome

REACT_9470. Signaling by FGFR.

Gene expression databases

ArrayExpress

Q9NP95.

Bgee

Q9NP95.

CleanEx

HS_FGF20.

Genevestigator

Q9NP95.

GermOnline

ENSG00000078579. Homo sapiens.

Family and domain databases

InterPro

IPR008996. Cytokine_IL1-like.
IPR002209. GF_heparin_bd.
IPR002348. IL1_HBGF.
[Graphical view]

PANTHER

PTHR11486. IL1_HBGF. 1 hit.

Pfam

PF00167. FGF. 1 hit.
[Graphical view]

PRINTS

PR00263. HBGFFGF.
PR00262. IL1HBGF.

SMART

SM00442. FGF. 1 hit.
[Graphical view]

PROSITE

PS00247. HBGF_FGF. 1 hit.
[Graphical view]

ProtoNet

Search...

Other Resources

NextBio

48605.

SOURCE

Search...

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Entry information

Entry name

FGF20_HUMAN

Accession

Primary (citable) accession number: Q9NP95

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 27, 2001
Last sequence update:	October 1, 2000
Last modified:	January 19, 2010
This is version 71 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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