Reviewed,
UniProtKB/Swiss-Prot Q9NP95 (FGF20_HUMAN)
Last modified
January 19, 2010.
Version 71.
History...
Clusters with 100%,
90%,
50% identity |
Documents (6) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Fibroblast growth factor 20 Short name=FGF-20 | ||
| Gene names |
| ||
| Organism | Homo sapiens (Human) [Complete proteome] | ||
| Taxonomic identifier | 9606 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 211 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Neurotrophic factor that regulates central nervous development and function. |
| Subcellular location | |
| Tissue specificity | Predominantly expressed in the cerebellum. Ref.3 |
| Sequence similarities | Belongs to the heparin-binding growth factors family. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Secreted |
| Coding sequence diversity | Polymorphism |
| Molecular function | Growth factor |
| Technical term | 3D-structure Complete proteome |
| Gene Ontology (GO) | |
| Biological process | cell growth Inferred from mutant phenotype. Source: UniProtKB cell-cell signaling Ref.1Traceable author statement. Source: ProtInc fibroblast growth factor receptor signaling pathwayInferred from Experiment. Source: Reactome |
| Cellular component | extracellular region Ref.1 Inferred from Experiment. Source: Reactome soluble fraction Ref.1Traceable author statement. Source: ProtInc |
| Molecular function | growth factor activity Inferred from electronic annotation. Source: UniProtKB-KW |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||||||||||||||||||||||||||
Molecule processing | |||||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 211 | 211 | Fibroblast growth factor 20 | PRO_0000147616 | |||||||||||||||||||||||||||||
Natural variations | |||||||||||||||||||||||||||||||||
| Natural variant | 116 | 1 | G → R: dbSNP rs3793405. Ref.4 | VAR_020946 | |||||||||||||||||||||||||||||
| Natural variant | 175 | 1 | P → A: dbSNP rs10089600. Ref.4 | VAR_020947 | |||||||||||||||||||||||||||||
| Natural variant | 206 | 1 | D → N: dbSNP rs17550360. Ref.4 | VAR_020948 | |||||||||||||||||||||||||||||
Secondary structure | |||||||||||||||||||||||||||||||||
Helix Strand Turn | |||||||||||||||||||||||||||||||||
| Helix | 56 – 60 | 5 | |||||||||||||||||||||||||||||||
| Beta strand | 66 – 71 | 6 | |||||||||||||||||||||||||||||||
| Beta strand | 98 – 101 | 4 | |||||||||||||||||||||||||||||||
| Beta strand | 108 – 111 | 4 | |||||||||||||||||||||||||||||||
| Helix | 135 – 137 | 3 | |||||||||||||||||||||||||||||||
| Beta strand | 139 – 145 | 7 | |||||||||||||||||||||||||||||||
| Beta strand | 148 – 157 | 10 | |||||||||||||||||||||||||||||||
| Beta strand | 164 – 166 | 3 | |||||||||||||||||||||||||||||||
| Helix | 186 – 188 | 3 | |||||||||||||||||||||||||||||||
| Beta strand | 190 – 193 | 4 | |||||||||||||||||||||||||||||||
| Helix | 197 – 199 | 3 | |||||||||||||||||||||||||||||||
| Helix | 201 – 203 | 3 | |||||||||||||||||||||||||||||||
Sequences
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References
| [1] | "Molecular cloning and characterization of human FGF-20 on chromosome 8p21.3-p22." Kirikoshi H., Sagara N., Saitoh T., Tanaka K., Sekihara H., Shiokawa K., Katoh M. Biochem. Biophys. Res. Commun. 274:337-343(2000) [PubMed: 10913340] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. |
| [2] | "FGF-20, a novel neurotrophic factor, preferentially expressed in the substantia nigra pars compacta of rat brain." Ohmachi S., Watanabe Y., Mikami T., Kusu N., Ibi T., Akaike A., Itoh N. Biochem. Biophys. Res. Commun. 277:355-360(2000) [PubMed: 11032730] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Brain. |
| [3] | "Identification of a novel human fibroblast growth factor and characterization of its role in oncogenesis." Jeffers M., Shimkets R., Prayaga S., Boldog F., Yang M., Burgess C., Fernandes E., Rittman B., Shimkets J., LaRochelle W.J., Lichenstein H.S. Cancer Res. 61:3131-3138(2001) [PubMed: 11306498] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, TISSUE SPECIFICITY. |
| [4] | NIEHS SNPs program Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS ARG-116; ALA-175 AND ASN-206. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| EMBL GenBank DDBJ | AB044277 mRNA. Translation: BAB03633.1. AB030648 mRNA. Translation: BAB03530.1. AY696296 Genomic DNA. Translation: AAT85804.1. | ||||||||||||
| IPI | IPI00014608. | ||||||||||||
| PIR | JC7353. | ||||||||||||
| RefSeq | NP_062825.1. | ||||||||||||
| UniGene | Hs.199905 | ||||||||||||
3D structure databases | |||||||||||||
| PDBe RCSB PDB PDBj |
| ||||||||||||
| ModBase | Search... | ||||||||||||
Protein-protein interaction databases | |||||||||||||
| STRING | Q9NP95. | ||||||||||||
Proteomic databases | |||||||||||||
| PRIDE | Q9NP95. | ||||||||||||
Genome annotation databases | |||||||||||||
| Ensembl | ENST00000180166; ENSP00000180166; ENSG00000078579; Homo sapiens. [Genome view] | ||||||||||||
| GeneID | 26281. | ||||||||||||
| KEGG | hsa:26281. | ||||||||||||
| UCSC | uc003wxc.1. human. | ||||||||||||
Organism-specific databases | |||||||||||||
| CTD | 26281. | ||||||||||||
| GeneCards | GC08M016894. | ||||||||||||
| H-InvDB | HIX0034235. | ||||||||||||
| HGNC | HGNC:3677. FGF20. | ||||||||||||
| MIM | 605558. gene. | ||||||||||||
| PharmGKB | PA28116. | ||||||||||||
| GenAtlas | Search... | ||||||||||||
Phylogenomic databases | |||||||||||||
| HOGENOM | HBG715603. | ||||||||||||
| HOVERGEN | Q9NP95. | ||||||||||||
| InParanoid | Q9NP95. | ||||||||||||
| OMA | KDILMYS. | ||||||||||||
| OrthoDB | EOG9N5ZG3. | ||||||||||||
| PhylomeDB | Q9NP95. | ||||||||||||
Enzyme and pathway databases | |||||||||||||
| Reactome | REACT_9470. Signaling by FGFR. | ||||||||||||
Gene expression databases | |||||||||||||
| ArrayExpress | Q9NP95. | ||||||||||||
| Bgee | Q9NP95. | ||||||||||||
| CleanEx | HS_FGF20. | ||||||||||||
| Genevestigator | Q9NP95. | ||||||||||||
| GermOnline | ENSG00000078579. Homo sapiens. | ||||||||||||
Family and domain databases | |||||||||||||
| InterPro | IPR008996. Cytokine_IL1-like. IPR002209. GF_heparin_bd. IPR002348. IL1_HBGF. [Graphical view] | ||||||||||||
| PANTHER | PTHR11486. IL1_HBGF. 1 hit. | ||||||||||||
| Pfam | PF00167. FGF. 1 hit. [Graphical view] | ||||||||||||
| PRINTS | PR00263. HBGFFGF. PR00262. IL1HBGF. | ||||||||||||
| SMART | SM00442. FGF. 1 hit. [Graphical view] | ||||||||||||
| PROSITE | PS00247. HBGF_FGF. 1 hit. [Graphical view] | ||||||||||||
| ProtoNet | Search... | ||||||||||||
Other Resources | |||||||||||||
| NextBio | 48605. | ||||||||||||
| SOURCE | Search... | ||||||||||||
Entry information
| Entry name | FGF20_HUMAN | ||||||||
| Accession | Primary (citable) accession number: Q9NP95 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
| Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. | ||||||||
Relevant documents
| Human chromosome 8 Human chromosome 8: entries, gene names and cross-references to MIM |
| Human entries with polymorphisms or disease mutations List of human entries with polymorphisms or disease mutations |
| Human polymorphisms and disease mutations Index of human polymorphisms and disease mutations |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| PDB cross-references Index of Protein Data Bank (PDB) cross-references |
| SIMILARITY comments Index of protein domains and families |

Clusters with


