Q9NP94 (S39A2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Zinc transporter ZIP2

Alternative name(s):
6A1
Eti-1
Solute carrier family 39 member 2
Zrt- and Irt-like protein 2
Short name=ZIP-2
Short name=hZIP2

Gene names

Name:	SLC39A2
Synonyms:	ZIP2

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	309 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Mediates zinc uptake. Zinc uptake may be mediated by a Zn2+-HCO3- symport mechanism and can function in the presence of albumin. May also transport other divalent cations. May be important in contact inhibition of normal epithelial cells and loss of its expression may play a role in tumorigenesis.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Tissue specificity	Expressed only in prostate and uterine epithelial cells.
Induction	Shows a dramatic induction in normal epithelial cells contact inhibition.
Miscellaneous	Zinc uptake is inhibited at pH levels below 7.0 and is stimulated at higher pH and is significantly inhibited by Cu2+, Co2+ and Mn2+ ions. Not inhibited by Fe2+.
Sequence similarities	Belongs to the ZIP transporter (TC 2.A.5) family. [View classification]

Ontologies

Keywords
Biological process	Ion transport Transport Zinc transport
Cellular component	Cell membrane Membrane
Coding sequence diversity	Polymorphism
Domain	Transmembrane Transmembrane helix
Ligand	Zinc
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	cytoplasmic membrane-bounded vesicle Inferred from direct assay PubMed 14612438. Source: UniProtKB integral to plasma membrane Traceable author statement Ref.2. Source: ProtInc
Molecular_function	zinc ion transmembrane transporter activity Inferred from mutant phenotype PubMed 20148757. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 309	309	Zinc transporter ZIP2		PRO_0000068767
Regions
	Topological domain	1 – 8	8	Extracellular Potential
	Transmembrane	9 – 29	21	Helical; Potential
	Topological domain	30 – 46	17	Cytoplasmic Potential
	Transmembrane	47 – 67	21	Helical; Potential
	Topological domain	68 – 103	36	Extracellular Potential
	Transmembrane	104 – 124	21	Helical; Potential
	Topological domain	125 – 164	40	Cytoplasmic Potential
	Transmembrane	165 – 185	21	Helical; Potential
	Topological domain	186 – 189	4	Extracellular Potential
	Transmembrane	190 – 210	21	Helical; Potential
	Topological domain	211 – 224	14	Cytoplasmic Potential
	Transmembrane	225 – 245	21	Helical; Potential
	Topological domain	246 – 258	13	Extracellular Potential
	Transmembrane	259 – 279	21	Helical; Potential
	Topological domain	280 – 288	9	Cytoplasmic Potential
	Transmembrane	289 – 309	21	Helical; Potential
	Region	175 – 176	2	Heavy metals binding By similarity
Natural variations
	Natural variant	48	1	L → P. Corresponds to variant rs2234633 [ dbSNP | Ensembl ].		VAR_057480
	Natural variant	80	1	M → V. Corresponds to variant rs2234634 [ dbSNP | Ensembl ].		VAR_020265
	Natural variant	115	1	F → L. Ref.1 Ref.2 Ref.5 Corresponds to variant rs2234636 [ dbSNP | Ensembl ].		VAR_055452
	Natural variant	129	1	G → E. Corresponds to variant rs6413532 [ dbSNP | Ensembl ].		VAR_020266
	Natural variant	154	1	H → Y. Corresponds to variant rs2234637 [ dbSNP | Ensembl ].		VAR_020267
Experimental info
	Sequence conflict	12	1	L → P in AAH98254. Ref.5
	Sequence conflict	43	1	L → R in BAA94313. Ref.1
	Sequence conflict	43	1	L → R in AAF35832. Ref.2
	Sequence conflict	43	1	L → R in AAH96723. Ref.5
	Sequence conflict	43	1	L → R in AAH98254. Ref.5
	Sequence conflict	43	1	L → R in AAI10058. Ref.5
	Sequence conflict	120	1	E → V in BAG37473. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Q9NP94 [UniParc]. Last modified May 18, 2010. Version 2. Checksum: C71A0BF8533B5D51	FASTA	309	32,742
	10 20 30 40 50 60 MEQLLGIKLG CLFALLALTL GCGLTPICFK WFQIDAARGH HRLVLRLLGC ISAGVFLGAG 70 80 90 100 110 120 FMHMTAEALE EIESQIQKFM VQNRSASERN SSGDADSAHM EYPYGELIIS LGFFFVFFLE 130 140 150 160 170 180 SLALQCCPGA AGGSTVQDEE WGGAHIFELH SHGHLPSPSK GPLRALVLLL SLSFHSVFEG 190 200 210 220 230 240 LAVGLQPTVA ATVQLCLAVL AHKGLVVFGV GMRLVHLGTS SRWAVFSILL LALMSPLGLA 250 260 270 280 290 300 VGLAVTGGDS EGGRGLAQAV LEGVAAGTFL YVTFLEILPR ELASPEAPLA KWSCVAAGFA FMAFIALWA

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Subtraction cloning of growth arrest inducible genes in normal human epithelial cells." Yamaguchi S. Kokubyo Gakkai Zasshi 62:78-93(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT LEU-115. Tissue: Uterine ectocervix.
[2]	"Functional expression of the human hZIP2 zinc transporter." Gaither L.A., Eide D.J. J. Biol. Chem. 275:5560-5564(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], CHARACTERIZATION, VARIANT LEU-115. Tissue: Prostate.
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Prostate.
[4]	"The DNA sequence and analysis of human chromosome 14." Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H. , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J. Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT LEU-115.
[6]	"Expression of zinc transporters in human prostate." Nong G., Buszko M.L., Sweeney C.A., Furman J., Rice L.P. Submitted (APR-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 183-242. Tissue: Prostate.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	D83039 mRNA. Translation: BAA94313.1. AF186081 mRNA. Translation: AAF35832.1. AK314974 mRNA. Translation: BAG37473.1. AL161668 Genomic DNA. No translation available. AL355922 Genomic DNA. No translation available. BC096723 mRNA. Translation: AAH96723.1. BC098254 mRNA. Translation: AAH98254.1. BC110057 mRNA. Translation: AAI10058.1. AY029483 mRNA. Translation: AAK40258.1.
IPI	IPI00005148.
RefSeq	NP_055394.2. NM_014579.3.
UniGene	Hs.175783.
3D structure databases
ProteinModelPortal	Q9NP94.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000298681.
Protein family/group databases
TCDB	2.A.5.3.1. zinc (Zn2+)-iron (Fe2+) permease (ZIP) family.
Polymorphism databases
DMDM	296452889.
Proteomic databases
PaxDb	Q9NP94.
PRIDE	Q9NP94.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000298681; ENSP00000298681; ENSG00000165794.
GeneID	29986.
KEGG	hsa:29986.
UCSC	uc001vyr.3. human.
Organism-specific databases
CTD	29986.
GeneCards	GC14P021467.
H-InvDB	HIX0202098.
HGNC	HGNC:17127. SLC39A2.
HPA	HPA030489.
MIM	612166. gene.
neXtProt	NX_Q9NP94.
PharmGKB	PA38202.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG321162.
HOGENOM	HOG000236331.
HOVERGEN	HBG015174.
InParanoid	Q9NP94.
KO	K14709.
OMA	AIMATIM.
OrthoDB	EOG43TZWD.
PhylomeDB	Q9NP94.
Enzyme and pathway databases
Reactome	REACT_15518. Transmembrane transport of small molecules.
Gene expression databases
ArrayExpress	Q9NP94.
Bgee	Q9NP94.
CleanEx	HS_SLC39A2.
Genevestigator	Q9NP94.
GermOnline	ENSG00000165794. Homo sapiens.
Family and domain databases
InterPro	IPR003689. ZIP. [Graphical view]
Pfam	PF02535. Zip. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	29986.
NextBio	52756.
SOURCE	Search...

Entry information

Entry name

S39A2_HUMAN

Accession

Primary (citable) accession number: Q9NP94
Secondary accession number(s): B2RC76 , Q4QQJ1, Q4V9S4, Q96JT6, Q9UD20

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 26, 2003
Last sequence update:	May 18, 2010
Last modified:	April 3, 2013
This is version 89 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.