Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Zinc transporter ZIP2

Gene

SLC39A2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Mediates zinc uptake. Zinc uptake may be mediated by a Zn2+-HCO3- symport mechanism and can function in the presence of albumin. May also transport other divalent cations. May be important in contact inhibition of normal epithelial cells and loss of its expression may play a role in tumorigenesis.

GO - Molecular functioni

  • zinc ion transmembrane transporter activity Source: UniProtKB

GO - Biological processi

  • zinc II ion transport Source: ProtInc
Complete GO annotation...

Keywords - Biological processi

Ion transport, Transport, Zinc transport

Keywords - Ligandi

Zinc

Enzyme and pathway databases

BioCyciZFISH:ENSG00000165794-MONOMER.
ReactomeiR-HSA-442380. Zinc influx into cells by the SLC39 gene family.

Protein family/group databases

TCDBi2.A.5.3.1. the zinc (zn(2+))-iron (fe(2+)) permease (zip) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc transporter ZIP2
Alternative name(s):
6A1
Eti-1
Solute carrier family 39 member 2
Zrt- and Irt-like protein 2
Short name:
ZIP-2
Short name:
hZIP2
Gene namesi
Name:SLC39A2
Synonyms:ZIP2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

HGNCiHGNC:17127. SLC39A2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 8ExtracellularSequence analysis8
Transmembranei9 – 29HelicalSequence analysisAdd BLAST21
Topological domaini30 – 46CytoplasmicSequence analysisAdd BLAST17
Transmembranei47 – 67HelicalSequence analysisAdd BLAST21
Topological domaini68 – 103ExtracellularSequence analysisAdd BLAST36
Transmembranei104 – 124HelicalSequence analysisAdd BLAST21
Topological domaini125 – 164CytoplasmicSequence analysisAdd BLAST40
Transmembranei165 – 185HelicalSequence analysisAdd BLAST21
Topological domaini186 – 189ExtracellularSequence analysis4
Transmembranei190 – 210HelicalSequence analysisAdd BLAST21
Topological domaini211 – 224CytoplasmicSequence analysisAdd BLAST14
Transmembranei225 – 245HelicalSequence analysisAdd BLAST21
Topological domaini246 – 258ExtracellularSequence analysisAdd BLAST13
Transmembranei259 – 279HelicalSequence analysisAdd BLAST21
Topological domaini280 – 288CytoplasmicSequence analysis9
Transmembranei289 – 309HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

  • cytoplasmic, membrane-bounded vesicle Source: UniProtKB
  • integral component of plasma membrane Source: ProtInc
  • plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi29986.
OpenTargetsiENSG00000165794.
PharmGKBiPA38202.

Polymorphism and mutation databases

BioMutaiSLC39A2.
DMDMi296452889.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000687671 – 309Zinc transporter ZIP2Add BLAST309

Proteomic databases

PaxDbiQ9NP94.
PRIDEiQ9NP94.

Expressioni

Tissue specificityi

Expressed only in prostate and uterine epithelial cells.

Inductioni

Shows a dramatic induction in normal epithelial cells contact inhibition.

Gene expression databases

BgeeiENSG00000165794.
CleanExiHS_SLC39A2.
GenevisibleiQ9NP94. HS.

Organism-specific databases

HPAiHPA030489.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000298681.

Structurei

3D structure databases

ProteinModelPortaliQ9NP94.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni175 – 176Heavy metals bindingBy similarity2

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1558. Eukaryota.
ENOG4111GP2. LUCA.
GeneTreeiENSGT00530000063242.
HOGENOMiHOG000236331.
HOVERGENiHBG015174.
InParanoidiQ9NP94.
KOiK14709.
OMAiQDEEWGG.
OrthoDBiEOG091G0DW2.
PhylomeDBiQ9NP94.
TreeFamiTF317098.

Family and domain databases

InterProiIPR003689. ZIP.
[Graphical view]
PfamiPF02535. Zip. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9NP94-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEQLLGIKLG CLFALLALTL GCGLTPICFK WFQIDAARGH HRLVLRLLGC
60 70 80 90 100
ISAGVFLGAG FMHMTAEALE EIESQIQKFM VQNRSASERN SSGDADSAHM
110 120 130 140 150
EYPYGELIIS LGFFFVFFLE SLALQCCPGA AGGSTVQDEE WGGAHIFELH
160 170 180 190 200
SHGHLPSPSK GPLRALVLLL SLSFHSVFEG LAVGLQPTVA ATVQLCLAVL
210 220 230 240 250
AHKGLVVFGV GMRLVHLGTS SRWAVFSILL LALMSPLGLA VGLAVTGGDS
260 270 280 290 300
EGGRGLAQAV LEGVAAGTFL YVTFLEILPR ELASPEAPLA KWSCVAAGFA

FMAFIALWA
Length:309
Mass (Da):32,742
Last modified:May 18, 2010 - v2
Checksum:iC71A0BF8533B5D51
GO
Isoform 2 (identifier: Q9NP94-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     83-85: NRS → ISK
     86-309: Missing.

Note: Gene prediction based on EST data.
Show »
Length:85
Mass (Da):9,349
Checksum:i64748ED4523960D2
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti12L → P in AAH98254 (PubMed:15489334).Curated1
Sequence conflicti43L → R in BAA94313 (PubMed:7751801).Curated1
Sequence conflicti43L → R in AAF35832 (PubMed:10681536).Curated1
Sequence conflicti43L → R in AAH96723 (PubMed:15489334).Curated1
Sequence conflicti43L → R in AAH98254 (PubMed:15489334).Curated1
Sequence conflicti43L → R in AAI10058 (PubMed:15489334).Curated1
Sequence conflicti120E → V in BAG37473 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05748048L → P.Corresponds to variant rs2234633dbSNPEnsembl.1
Natural variantiVAR_02026580M → V.Corresponds to variant rs2234634dbSNPEnsembl.1
Natural variantiVAR_055452115F → L.3 PublicationsCorresponds to variant rs2234636dbSNPEnsembl.1
Natural variantiVAR_020266129G → E.Corresponds to variant rs6413532dbSNPEnsembl.1
Natural variantiVAR_020267154H → Y.Corresponds to variant rs2234637dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_04688983 – 85NRS → ISK in isoform 2. Curated3
Alternative sequenceiVSP_04689086 – 309Missing in isoform 2. CuratedAdd BLAST224

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D83039 mRNA. Translation: BAA94313.1.
AF186081 mRNA. Translation: AAF35832.1.
AK314974 mRNA. Translation: BAG37473.1.
AL161668 Genomic DNA. No translation available.
AL355922 Genomic DNA. No translation available.
BC096723 mRNA. Translation: AAH96723.1.
BC098254 mRNA. Translation: AAH98254.1.
BC110057 mRNA. Translation: AAI10058.1.
AY029483 mRNA. Translation: AAK40258.1.
CCDSiCCDS58303.1. [Q9NP94-2]
CCDS9563.1. [Q9NP94-1]
RefSeqiNP_001243517.1. NM_001256588.1. [Q9NP94-2]
NP_055394.2. NM_014579.3. [Q9NP94-1]
UniGeneiHs.175783.

Genome annotation databases

EnsembliENST00000298681; ENSP00000298681; ENSG00000165794. [Q9NP94-1]
ENST00000554422; ENSP00000452568; ENSG00000165794. [Q9NP94-2]
GeneIDi29986.
KEGGihsa:29986.
UCSCiuc001vyr.4. human. [Q9NP94-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D83039 mRNA. Translation: BAA94313.1.
AF186081 mRNA. Translation: AAF35832.1.
AK314974 mRNA. Translation: BAG37473.1.
AL161668 Genomic DNA. No translation available.
AL355922 Genomic DNA. No translation available.
BC096723 mRNA. Translation: AAH96723.1.
BC098254 mRNA. Translation: AAH98254.1.
BC110057 mRNA. Translation: AAI10058.1.
AY029483 mRNA. Translation: AAK40258.1.
CCDSiCCDS58303.1. [Q9NP94-2]
CCDS9563.1. [Q9NP94-1]
RefSeqiNP_001243517.1. NM_001256588.1. [Q9NP94-2]
NP_055394.2. NM_014579.3. [Q9NP94-1]
UniGeneiHs.175783.

3D structure databases

ProteinModelPortaliQ9NP94.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000298681.

Protein family/group databases

TCDBi2.A.5.3.1. the zinc (zn(2+))-iron (fe(2+)) permease (zip) family.

Polymorphism and mutation databases

BioMutaiSLC39A2.
DMDMi296452889.

Proteomic databases

PaxDbiQ9NP94.
PRIDEiQ9NP94.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000298681; ENSP00000298681; ENSG00000165794. [Q9NP94-1]
ENST00000554422; ENSP00000452568; ENSG00000165794. [Q9NP94-2]
GeneIDi29986.
KEGGihsa:29986.
UCSCiuc001vyr.4. human. [Q9NP94-1]

Organism-specific databases

CTDi29986.
DisGeNETi29986.
GeneCardsiSLC39A2.
H-InvDBHIX0202098.
HGNCiHGNC:17127. SLC39A2.
HPAiHPA030489.
MIMi612166. gene.
neXtProtiNX_Q9NP94.
OpenTargetsiENSG00000165794.
PharmGKBiPA38202.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1558. Eukaryota.
ENOG4111GP2. LUCA.
GeneTreeiENSGT00530000063242.
HOGENOMiHOG000236331.
HOVERGENiHBG015174.
InParanoidiQ9NP94.
KOiK14709.
OMAiQDEEWGG.
OrthoDBiEOG091G0DW2.
PhylomeDBiQ9NP94.
TreeFamiTF317098.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000165794-MONOMER.
ReactomeiR-HSA-442380. Zinc influx into cells by the SLC39 gene family.

Miscellaneous databases

GeneWikiiSLC39A2.
GenomeRNAii29986.
PROiQ9NP94.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000165794.
CleanExiHS_SLC39A2.
GenevisibleiQ9NP94. HS.

Family and domain databases

InterProiIPR003689. ZIP.
[Graphical view]
PfamiPF02535. Zip. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiS39A2_HUMAN
AccessioniPrimary (citable) accession number: Q9NP94
Secondary accession number(s): B2RC76
, G3V5X2, Q4QQJ1, Q4V9S4, Q96JT6, Q9UD20
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 26, 2003
Last sequence update: May 18, 2010
Last modified: November 2, 2016
This is version 117 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Zinc uptake is inhibited at pH levels below 7.0 and is stimulated at higher pH and is significantly inhibited by Cu2+, Co2+ and Mn2+ ions. Not inhibited by Fe2+.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.