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Q9NP94 (S39A2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 100. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Zinc transporter ZIP2
Alternative name(s):
6A1
Eti-1
Solute carrier family 39 member 2
Zrt- and Irt-like protein 2
Short name=ZIP-2
Short name=hZIP2
Gene names
Name:SLC39A2
Synonyms:ZIP2
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length309 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Mediates zinc uptake. Zinc uptake may be mediated by a Zn2+-HCO3- symport mechanism and can function in the presence of albumin. May also transport other divalent cations. May be important in contact inhibition of normal epithelial cells and loss of its expression may play a role in tumorigenesis.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Tissue specificity

Expressed only in prostate and uterine epithelial cells.

Induction

Shows a dramatic induction in normal epithelial cells contact inhibition.

Miscellaneous

Zinc uptake is inhibited at pH levels below 7.0 and is stimulated at higher pH and is significantly inhibited by Cu2+, Co2+ and Mn2+ ions. Not inhibited by Fe2+.

Sequence similarities

Belongs to the ZIP transporter (TC 2.A.5) family. [View classification]

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q9NP94-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q9NP94-2)

The sequence of this isoform differs from the canonical sequence as follows:
     83-85: NRS → ISK
     86-309: Missing.
Note: Gene prediction based on EST data.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 309309Zinc transporter ZIP2
PRO_0000068767

Regions

Topological domain1 – 88Extracellular Potential
Transmembrane9 – 2921Helical; Potential
Topological domain30 – 4617Cytoplasmic Potential
Transmembrane47 – 6721Helical; Potential
Topological domain68 – 10336Extracellular Potential
Transmembrane104 – 12421Helical; Potential
Topological domain125 – 16440Cytoplasmic Potential
Transmembrane165 – 18521Helical; Potential
Topological domain186 – 1894Extracellular Potential
Transmembrane190 – 21021Helical; Potential
Topological domain211 – 22414Cytoplasmic Potential
Transmembrane225 – 24521Helical; Potential
Topological domain246 – 25813Extracellular Potential
Transmembrane259 – 27921Helical; Potential
Topological domain280 – 2889Cytoplasmic Potential
Transmembrane289 – 30921Helical; Potential
Region175 – 1762Heavy metals binding By similarity

Natural variations

Alternative sequence83 – 853NRS → ISK in isoform 2.
VSP_046889
Alternative sequence86 – 309224Missing in isoform 2.
VSP_046890
Natural variant481L → P.
Corresponds to variant rs2234633 [ dbSNP | Ensembl ].
VAR_057480
Natural variant801M → V.
Corresponds to variant rs2234634 [ dbSNP | Ensembl ].
VAR_020265
Natural variant1151F → L. Ref.1 Ref.2 Ref.5
Corresponds to variant rs2234636 [ dbSNP | Ensembl ].
VAR_055452
Natural variant1291G → E.
Corresponds to variant rs6413532 [ dbSNP | Ensembl ].
VAR_020266
Natural variant1541H → Y.
Corresponds to variant rs2234637 [ dbSNP | Ensembl ].
VAR_020267

Experimental info

Sequence conflict121L → P in AAH98254. Ref.5
Sequence conflict431L → R in BAA94313. Ref.1
Sequence conflict431L → R in AAF35832. Ref.2
Sequence conflict431L → R in AAH96723. Ref.5
Sequence conflict431L → R in AAH98254. Ref.5
Sequence conflict431L → R in AAI10058. Ref.5
Sequence conflict1201E → V in BAG37473. Ref.3

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified May 18, 2010. Version 2.
Checksum: C71A0BF8533B5D51

FASTA30932,742
        10         20         30         40         50         60 
MEQLLGIKLG CLFALLALTL GCGLTPICFK WFQIDAARGH HRLVLRLLGC ISAGVFLGAG 

        70         80         90        100        110        120 
FMHMTAEALE EIESQIQKFM VQNRSASERN SSGDADSAHM EYPYGELIIS LGFFFVFFLE 

       130        140        150        160        170        180 
SLALQCCPGA AGGSTVQDEE WGGAHIFELH SHGHLPSPSK GPLRALVLLL SLSFHSVFEG 

       190        200        210        220        230        240 
LAVGLQPTVA ATVQLCLAVL AHKGLVVFGV GMRLVHLGTS SRWAVFSILL LALMSPLGLA 

       250        260        270        280        290        300 
VGLAVTGGDS EGGRGLAQAV LEGVAAGTFL YVTFLEILPR ELASPEAPLA KWSCVAAGFA 


FMAFIALWA 

« Hide

Isoform 2 [UniParc].

Checksum: 64748ED4523960D2
Show »

FASTA859,349

References

« Hide 'large scale' references
[1]"Subtraction cloning of growth arrest inducible genes in normal human epithelial cells."
Yamaguchi S.
Kokubyo Gakkai Zasshi 62:78-93(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT LEU-115.
Tissue: Uterine ectocervix.
[2]"Functional expression of the human hZIP2 zinc transporter."
Gaither L.A., Eide D.J.
J. Biol. Chem. 275:5560-5564(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), CHARACTERIZATION, VARIANT LEU-115.
Tissue: Prostate.
[3]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Prostate.
[4]"The DNA sequence and analysis of human chromosome 14."
Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H. expand/collapse author list , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J.
Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT LEU-115.
[6]"Expression of zinc transporters in human prostate."
Nong G., Buszko M.L., Sweeney C.A., Furman J., Rice L.P.
Submitted (APR-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 183-242 (ISOFORM 1).
Tissue: Prostate.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
D83039 mRNA. Translation: BAA94313.1.
AF186081 mRNA. Translation: AAF35832.1.
AK314974 mRNA. Translation: BAG37473.1.
AL161668 Genomic DNA. No translation available.
AL355922 Genomic DNA. No translation available.
BC096723 mRNA. Translation: AAH96723.1.
BC098254 mRNA. Translation: AAH98254.1.
BC110057 mRNA. Translation: AAI10058.1.
AY029483 mRNA. Translation: AAK40258.1.
CCDSCCDS58303.1. [Q9NP94-2]
CCDS9563.1. [Q9NP94-1]
RefSeqNP_001243517.1. NM_001256588.1. [Q9NP94-2]
NP_055394.2. NM_014579.3. [Q9NP94-1]
UniGeneHs.175783.

3D structure databases

ProteinModelPortalQ9NP94.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000298681.

Protein family/group databases

TCDB2.A.5.3.1. the zinc (zn(2+))-iron (fe(2+)) permease (zip) family.

Polymorphism databases

DMDM296452889.

Proteomic databases

PaxDbQ9NP94.
PRIDEQ9NP94.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000298681; ENSP00000298681; ENSG00000165794. [Q9NP94-1]
ENST00000554422; ENSP00000452568; ENSG00000165794. [Q9NP94-2]
GeneID29986.
KEGGhsa:29986.
UCSCuc001vyr.3. human. [Q9NP94-1]

Organism-specific databases

CTD29986.
GeneCardsGC14P021467.
H-InvDBHIX0202098.
HGNCHGNC:17127. SLC39A2.
HPAHPA030489.
MIM612166. gene.
neXtProtNX_Q9NP94.
PharmGKBPA38202.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG321162.
HOGENOMHOG000236331.
HOVERGENHBG015174.
InParanoidQ9NP94.
KOK14709.
OMAAIMATIM.
OrthoDBEOG7M6D8Q.
PhylomeDBQ9NP94.
TreeFamTF317098.

Enzyme and pathway databases

ReactomeREACT_15518. Transmembrane transport of small molecules.

Gene expression databases

ArrayExpressQ9NP94.
BgeeQ9NP94.
CleanExHS_SLC39A2.
GenevestigatorQ9NP94.

Family and domain databases

InterProIPR003689. ZIP.
[Graphical view]
PfamPF02535. Zip. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiSLC39A2.
GenomeRNAi29986.
NextBio52756.
PROQ9NP94.
SOURCESearch...

Entry information

Entry nameS39A2_HUMAN
AccessionPrimary (citable) accession number: Q9NP94
Secondary accession number(s): B2RC76 expand/collapse secondary AC list , G3V5X2, Q4QQJ1, Q4V9S4, Q96JT6, Q9UD20
Entry history
Integrated into UniProtKB/Swiss-Prot: September 26, 2003
Last sequence update: May 18, 2010
Last modified: July 9, 2014
This is version 100 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 14

Human chromosome 14: entries, gene names and cross-references to MIM