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Q9NP94

- S39A2_HUMAN

UniProt

Q9NP94 - S39A2_HUMAN

Protein

Zinc transporter ZIP2

Gene

SLC39A2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 102 (01 Oct 2014)
      Sequence version 2 (18 May 2010)
      Previous versions | rss
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    Functioni

    Mediates zinc uptake. Zinc uptake may be mediated by a Zn2+-HCO3- symport mechanism and can function in the presence of albumin. May also transport other divalent cations. May be important in contact inhibition of normal epithelial cells and loss of its expression may play a role in tumorigenesis.

    GO - Molecular functioni

    1. zinc ion transmembrane transporter activity Source: UniProtKB

    GO - Biological processi

    1. transmembrane transport Source: Reactome
    2. zinc ion transport Source: ProtInc

    Keywords - Biological processi

    Ion transport, Transport, Zinc transport

    Keywords - Ligandi

    Zinc

    Enzyme and pathway databases

    ReactomeiREACT_20603. Zinc influx into cells by the SLC39 gene family.

    Protein family/group databases

    TCDBi2.A.5.3.1. the zinc (zn(2+))-iron (fe(2+)) permease (zip) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Zinc transporter ZIP2
    Alternative name(s):
    6A1
    Eti-1
    Solute carrier family 39 member 2
    Zrt- and Irt-like protein 2
    Short name:
    ZIP-2
    Short name:
    hZIP2
    Gene namesi
    Name:SLC39A2
    Synonyms:ZIP2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 14

    Organism-specific databases

    HGNCiHGNC:17127. SLC39A2.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasmic membrane-bounded vesicle Source: UniProtKB
    2. integral component of plasma membrane Source: ProtInc
    3. plasma membrane Source: UniProtKB

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA38202.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 309309Zinc transporter ZIP2PRO_0000068767Add
    BLAST

    Proteomic databases

    PaxDbiQ9NP94.
    PRIDEiQ9NP94.

    Expressioni

    Tissue specificityi

    Expressed only in prostate and uterine epithelial cells.

    Inductioni

    Shows a dramatic induction in normal epithelial cells contact inhibition.

    Gene expression databases

    ArrayExpressiQ9NP94.
    BgeeiQ9NP94.
    CleanExiHS_SLC39A2.
    GenevestigatoriQ9NP94.

    Organism-specific databases

    HPAiHPA030489.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000298681.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9NP94.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 88ExtracellularSequence Analysis
    Topological domaini30 – 4617CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini68 – 10336ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini125 – 16440CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini186 – 1894ExtracellularSequence Analysis
    Topological domaini211 – 22414CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini246 – 25813ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini280 – 2889CytoplasmicSequence Analysis

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei9 – 2921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei47 – 6721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei104 – 12421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei165 – 18521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei190 – 21021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei225 – 24521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei259 – 27921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei289 – 30921HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni175 – 1762Heavy metals bindingBy similarity

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG321162.
    HOGENOMiHOG000236331.
    HOVERGENiHBG015174.
    InParanoidiQ9NP94.
    KOiK14709.
    OMAiAIMATIM.
    OrthoDBiEOG7M6D8Q.
    PhylomeDBiQ9NP94.
    TreeFamiTF317098.

    Family and domain databases

    InterProiIPR003689. ZIP.
    [Graphical view]
    PfamiPF02535. Zip. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9NP94-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MEQLLGIKLG CLFALLALTL GCGLTPICFK WFQIDAARGH HRLVLRLLGC    50
    ISAGVFLGAG FMHMTAEALE EIESQIQKFM VQNRSASERN SSGDADSAHM 100
    EYPYGELIIS LGFFFVFFLE SLALQCCPGA AGGSTVQDEE WGGAHIFELH 150
    SHGHLPSPSK GPLRALVLLL SLSFHSVFEG LAVGLQPTVA ATVQLCLAVL 200
    AHKGLVVFGV GMRLVHLGTS SRWAVFSILL LALMSPLGLA VGLAVTGGDS 250
    EGGRGLAQAV LEGVAAGTFL YVTFLEILPR ELASPEAPLA KWSCVAAGFA 300
    FMAFIALWA 309
    Length:309
    Mass (Da):32,742
    Last modified:May 18, 2010 - v2
    Checksum:iC71A0BF8533B5D51
    GO
    Isoform 2 (identifier: Q9NP94-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         83-85: NRS → ISK
         86-309: Missing.

    Note: Gene prediction based on EST data.

    Show »
    Length:85
    Mass (Da):9,349
    Checksum:i64748ED4523960D2
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti12 – 121L → P in AAH98254. (PubMed:15489334)Curated
    Sequence conflicti43 – 431L → R in BAA94313. (PubMed:7751801)Curated
    Sequence conflicti43 – 431L → R in AAF35832. (PubMed:10681536)Curated
    Sequence conflicti43 – 431L → R in AAH96723. (PubMed:15489334)Curated
    Sequence conflicti43 – 431L → R in AAH98254. (PubMed:15489334)Curated
    Sequence conflicti43 – 431L → R in AAI10058. (PubMed:15489334)Curated
    Sequence conflicti120 – 1201E → V in BAG37473. (PubMed:14702039)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti48 – 481L → P.
    Corresponds to variant rs2234633 [ dbSNP | Ensembl ].
    VAR_057480
    Natural varianti80 – 801M → V.
    Corresponds to variant rs2234634 [ dbSNP | Ensembl ].
    VAR_020265
    Natural varianti115 – 1151F → L.3 Publications
    Corresponds to variant rs2234636 [ dbSNP | Ensembl ].
    VAR_055452
    Natural varianti129 – 1291G → E.
    Corresponds to variant rs6413532 [ dbSNP | Ensembl ].
    VAR_020266
    Natural varianti154 – 1541H → Y.
    Corresponds to variant rs2234637 [ dbSNP | Ensembl ].
    VAR_020267

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei83 – 853NRS → ISK in isoform 2. CuratedVSP_046889
    Alternative sequencei86 – 309224Missing in isoform 2. CuratedVSP_046890Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D83039 mRNA. Translation: BAA94313.1.
    AF186081 mRNA. Translation: AAF35832.1.
    AK314974 mRNA. Translation: BAG37473.1.
    AL161668 Genomic DNA. No translation available.
    AL355922 Genomic DNA. No translation available.
    BC096723 mRNA. Translation: AAH96723.1.
    BC098254 mRNA. Translation: AAH98254.1.
    BC110057 mRNA. Translation: AAI10058.1.
    AY029483 mRNA. Translation: AAK40258.1.
    CCDSiCCDS58303.1. [Q9NP94-2]
    CCDS9563.1. [Q9NP94-1]
    RefSeqiNP_001243517.1. NM_001256588.1. [Q9NP94-2]
    NP_055394.2. NM_014579.3. [Q9NP94-1]
    UniGeneiHs.175783.

    Genome annotation databases

    EnsembliENST00000298681; ENSP00000298681; ENSG00000165794. [Q9NP94-1]
    ENST00000554422; ENSP00000452568; ENSG00000165794. [Q9NP94-2]
    GeneIDi29986.
    KEGGihsa:29986.
    UCSCiuc001vyr.3. human. [Q9NP94-1]

    Polymorphism databases

    DMDMi296452889.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D83039 mRNA. Translation: BAA94313.1 .
    AF186081 mRNA. Translation: AAF35832.1 .
    AK314974 mRNA. Translation: BAG37473.1 .
    AL161668 Genomic DNA. No translation available.
    AL355922 Genomic DNA. No translation available.
    BC096723 mRNA. Translation: AAH96723.1 .
    BC098254 mRNA. Translation: AAH98254.1 .
    BC110057 mRNA. Translation: AAI10058.1 .
    AY029483 mRNA. Translation: AAK40258.1 .
    CCDSi CCDS58303.1. [Q9NP94-2 ]
    CCDS9563.1. [Q9NP94-1 ]
    RefSeqi NP_001243517.1. NM_001256588.1. [Q9NP94-2 ]
    NP_055394.2. NM_014579.3. [Q9NP94-1 ]
    UniGenei Hs.175783.

    3D structure databases

    ProteinModelPortali Q9NP94.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000298681.

    Protein family/group databases

    TCDBi 2.A.5.3.1. the zinc (zn(2+))-iron (fe(2+)) permease (zip) family.

    Polymorphism databases

    DMDMi 296452889.

    Proteomic databases

    PaxDbi Q9NP94.
    PRIDEi Q9NP94.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000298681 ; ENSP00000298681 ; ENSG00000165794 . [Q9NP94-1 ]
    ENST00000554422 ; ENSP00000452568 ; ENSG00000165794 . [Q9NP94-2 ]
    GeneIDi 29986.
    KEGGi hsa:29986.
    UCSCi uc001vyr.3. human. [Q9NP94-1 ]

    Organism-specific databases

    CTDi 29986.
    GeneCardsi GC14P021467.
    H-InvDB HIX0202098.
    HGNCi HGNC:17127. SLC39A2.
    HPAi HPA030489.
    MIMi 612166. gene.
    neXtProti NX_Q9NP94.
    PharmGKBi PA38202.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG321162.
    HOGENOMi HOG000236331.
    HOVERGENi HBG015174.
    InParanoidi Q9NP94.
    KOi K14709.
    OMAi AIMATIM.
    OrthoDBi EOG7M6D8Q.
    PhylomeDBi Q9NP94.
    TreeFami TF317098.

    Enzyme and pathway databases

    Reactomei REACT_20603. Zinc influx into cells by the SLC39 gene family.

    Miscellaneous databases

    GeneWikii SLC39A2.
    GenomeRNAii 29986.
    NextBioi 52756.
    PROi Q9NP94.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9NP94.
    Bgeei Q9NP94.
    CleanExi HS_SLC39A2.
    Genevestigatori Q9NP94.

    Family and domain databases

    InterProi IPR003689. ZIP.
    [Graphical view ]
    Pfami PF02535. Zip. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Subtraction cloning of growth arrest inducible genes in normal human epithelial cells."
      Yamaguchi S.
      Kokubyo Gakkai Zasshi 62:78-93(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT LEU-115.
      Tissue: Uterine ectocervix.
    2. "Functional expression of the human hZIP2 zinc transporter."
      Gaither L.A., Eide D.J.
      J. Biol. Chem. 275:5560-5564(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), CHARACTERIZATION, VARIANT LEU-115.
      Tissue: Prostate.
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Prostate.
    4. "The DNA sequence and analysis of human chromosome 14."
      Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H.
      , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J.
      Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT LEU-115.
    6. "Expression of zinc transporters in human prostate."
      Nong G., Buszko M.L., Sweeney C.A., Furman J., Rice L.P.
      Submitted (APR-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 183-242 (ISOFORM 1).
      Tissue: Prostate.

    Entry informationi

    Entry nameiS39A2_HUMAN
    AccessioniPrimary (citable) accession number: Q9NP94
    Secondary accession number(s): B2RC76
    , G3V5X2, Q4QQJ1, Q4V9S4, Q96JT6, Q9UD20
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 26, 2003
    Last sequence update: May 18, 2010
    Last modified: October 1, 2014
    This is version 102 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    Zinc uptake is inhibited at pH levels below 7.0 and is stimulated at higher pH and is significantly inhibited by Cu2+, Co2+ and Mn2+ ions. Not inhibited by Fe2+.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 14
      Human chromosome 14: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3