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Q9NP94

- S39A2_HUMAN

UniProt

Q9NP94 - S39A2_HUMAN

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Protein

Zinc transporter ZIP2

Gene
SLC39A2, ZIP2
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Mediates zinc uptake. Zinc uptake may be mediated by a Zn2+-HCO3- symport mechanism and can function in the presence of albumin. May also transport other divalent cations. May be important in contact inhibition of normal epithelial cells and loss of its expression may play a role in tumorigenesis.

GO - Molecular functioni

  1. zinc ion transmembrane transporter activity Source: UniProtKB

GO - Biological processi

  1. transmembrane transport Source: Reactome
  2. zinc ion transport Source: ProtInc
Complete GO annotation...

Keywords - Biological processi

Ion transport, Transport, Zinc transport

Keywords - Ligandi

Zinc

Enzyme and pathway databases

ReactomeiREACT_20603. Zinc influx into cells by the SLC39 gene family.

Protein family/group databases

TCDBi2.A.5.3.1. the zinc (zn(2+))-iron (fe(2+)) permease (zip) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc transporter ZIP2
Alternative name(s):
6A1
Eti-1
Solute carrier family 39 member 2
Zrt- and Irt-like protein 2
Short name:
ZIP-2
Short name:
hZIP2
Gene namesi
Name:SLC39A2
Synonyms:ZIP2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 14

Organism-specific databases

HGNCiHGNC:17127. SLC39A2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 88Extracellular Reviewed prediction
Transmembranei9 – 2921Helical; Reviewed predictionAdd
BLAST
Topological domaini30 – 4617Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei47 – 6721Helical; Reviewed predictionAdd
BLAST
Topological domaini68 – 10336Extracellular Reviewed predictionAdd
BLAST
Transmembranei104 – 12421Helical; Reviewed predictionAdd
BLAST
Topological domaini125 – 16440Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei165 – 18521Helical; Reviewed predictionAdd
BLAST
Topological domaini186 – 1894Extracellular Reviewed prediction
Transmembranei190 – 21021Helical; Reviewed predictionAdd
BLAST
Topological domaini211 – 22414Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei225 – 24521Helical; Reviewed predictionAdd
BLAST
Topological domaini246 – 25813Extracellular Reviewed predictionAdd
BLAST
Transmembranei259 – 27921Helical; Reviewed predictionAdd
BLAST
Topological domaini280 – 2889Cytoplasmic Reviewed prediction
Transmembranei289 – 30921Helical; Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. cytoplasmic membrane-bounded vesicle Source: UniProtKB
  2. integral component of plasma membrane Source: ProtInc
  3. plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA38202.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 309309Zinc transporter ZIP2PRO_0000068767Add
BLAST

Proteomic databases

PaxDbiQ9NP94.
PRIDEiQ9NP94.

Expressioni

Tissue specificityi

Expressed only in prostate and uterine epithelial cells.

Inductioni

Shows a dramatic induction in normal epithelial cells contact inhibition.

Gene expression databases

ArrayExpressiQ9NP94.
BgeeiQ9NP94.
CleanExiHS_SLC39A2.
GenevestigatoriQ9NP94.

Organism-specific databases

HPAiHPA030489.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000298681.

Structurei

3D structure databases

ProteinModelPortaliQ9NP94.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni175 – 1762Heavy metals binding By similarity

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG321162.
HOGENOMiHOG000236331.
HOVERGENiHBG015174.
InParanoidiQ9NP94.
KOiK14709.
OMAiAIMATIM.
OrthoDBiEOG7M6D8Q.
PhylomeDBiQ9NP94.
TreeFamiTF317098.

Family and domain databases

InterProiIPR003689. ZIP.
[Graphical view]
PfamiPF02535. Zip. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9NP94-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MEQLLGIKLG CLFALLALTL GCGLTPICFK WFQIDAARGH HRLVLRLLGC    50
ISAGVFLGAG FMHMTAEALE EIESQIQKFM VQNRSASERN SSGDADSAHM 100
EYPYGELIIS LGFFFVFFLE SLALQCCPGA AGGSTVQDEE WGGAHIFELH 150
SHGHLPSPSK GPLRALVLLL SLSFHSVFEG LAVGLQPTVA ATVQLCLAVL 200
AHKGLVVFGV GMRLVHLGTS SRWAVFSILL LALMSPLGLA VGLAVTGGDS 250
EGGRGLAQAV LEGVAAGTFL YVTFLEILPR ELASPEAPLA KWSCVAAGFA 300
FMAFIALWA 309
Length:309
Mass (Da):32,742
Last modified:May 18, 2010 - v2
Checksum:iC71A0BF8533B5D51
GO
Isoform 2 (identifier: Q9NP94-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     83-85: NRS → ISK
     86-309: Missing.

Note: Gene prediction based on EST data.

Show »
Length:85
Mass (Da):9,349
Checksum:i64748ED4523960D2
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti48 – 481L → P.
Corresponds to variant rs2234633 [ dbSNP | Ensembl ].
VAR_057480
Natural varianti80 – 801M → V.
Corresponds to variant rs2234634 [ dbSNP | Ensembl ].
VAR_020265
Natural varianti115 – 1151F → L.3 Publications
Corresponds to variant rs2234636 [ dbSNP | Ensembl ].
VAR_055452
Natural varianti129 – 1291G → E.
Corresponds to variant rs6413532 [ dbSNP | Ensembl ].
VAR_020266
Natural varianti154 – 1541H → Y.
Corresponds to variant rs2234637 [ dbSNP | Ensembl ].
VAR_020267

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei83 – 853NRS → ISK in isoform 2. VSP_046889
Alternative sequencei86 – 309224Missing in isoform 2. VSP_046890Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti12 – 121L → P in AAH98254. 1 Publication
Sequence conflicti43 – 431L → R in BAA94313. 1 Publication
Sequence conflicti43 – 431L → R in AAF35832. 1 Publication
Sequence conflicti43 – 431L → R in AAH96723. 1 Publication
Sequence conflicti43 – 431L → R in AAH98254. 1 Publication
Sequence conflicti43 – 431L → R in AAI10058. 1 Publication
Sequence conflicti120 – 1201E → V in BAG37473. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D83039 mRNA. Translation: BAA94313.1.
AF186081 mRNA. Translation: AAF35832.1.
AK314974 mRNA. Translation: BAG37473.1.
AL161668 Genomic DNA. No translation available.
AL355922 Genomic DNA. No translation available.
BC096723 mRNA. Translation: AAH96723.1.
BC098254 mRNA. Translation: AAH98254.1.
BC110057 mRNA. Translation: AAI10058.1.
AY029483 mRNA. Translation: AAK40258.1.
CCDSiCCDS58303.1. [Q9NP94-2]
CCDS9563.1. [Q9NP94-1]
RefSeqiNP_001243517.1. NM_001256588.1. [Q9NP94-2]
NP_055394.2. NM_014579.3. [Q9NP94-1]
UniGeneiHs.175783.

Genome annotation databases

EnsembliENST00000298681; ENSP00000298681; ENSG00000165794. [Q9NP94-1]
ENST00000554422; ENSP00000452568; ENSG00000165794. [Q9NP94-2]
GeneIDi29986.
KEGGihsa:29986.
UCSCiuc001vyr.3. human. [Q9NP94-1]

Polymorphism databases

DMDMi296452889.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D83039 mRNA. Translation: BAA94313.1 .
AF186081 mRNA. Translation: AAF35832.1 .
AK314974 mRNA. Translation: BAG37473.1 .
AL161668 Genomic DNA. No translation available.
AL355922 Genomic DNA. No translation available.
BC096723 mRNA. Translation: AAH96723.1 .
BC098254 mRNA. Translation: AAH98254.1 .
BC110057 mRNA. Translation: AAI10058.1 .
AY029483 mRNA. Translation: AAK40258.1 .
CCDSi CCDS58303.1. [Q9NP94-2 ]
CCDS9563.1. [Q9NP94-1 ]
RefSeqi NP_001243517.1. NM_001256588.1. [Q9NP94-2 ]
NP_055394.2. NM_014579.3. [Q9NP94-1 ]
UniGenei Hs.175783.

3D structure databases

ProteinModelPortali Q9NP94.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000298681.

Protein family/group databases

TCDBi 2.A.5.3.1. the zinc (zn(2+))-iron (fe(2+)) permease (zip) family.

Polymorphism databases

DMDMi 296452889.

Proteomic databases

PaxDbi Q9NP94.
PRIDEi Q9NP94.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000298681 ; ENSP00000298681 ; ENSG00000165794 . [Q9NP94-1 ]
ENST00000554422 ; ENSP00000452568 ; ENSG00000165794 . [Q9NP94-2 ]
GeneIDi 29986.
KEGGi hsa:29986.
UCSCi uc001vyr.3. human. [Q9NP94-1 ]

Organism-specific databases

CTDi 29986.
GeneCardsi GC14P021467.
H-InvDB HIX0202098.
HGNCi HGNC:17127. SLC39A2.
HPAi HPA030489.
MIMi 612166. gene.
neXtProti NX_Q9NP94.
PharmGKBi PA38202.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG321162.
HOGENOMi HOG000236331.
HOVERGENi HBG015174.
InParanoidi Q9NP94.
KOi K14709.
OMAi AIMATIM.
OrthoDBi EOG7M6D8Q.
PhylomeDBi Q9NP94.
TreeFami TF317098.

Enzyme and pathway databases

Reactomei REACT_20603. Zinc influx into cells by the SLC39 gene family.

Miscellaneous databases

GeneWikii SLC39A2.
GenomeRNAii 29986.
NextBioi 52756.
PROi Q9NP94.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9NP94.
Bgeei Q9NP94.
CleanExi HS_SLC39A2.
Genevestigatori Q9NP94.

Family and domain databases

InterProi IPR003689. ZIP.
[Graphical view ]
Pfami PF02535. Zip. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Subtraction cloning of growth arrest inducible genes in normal human epithelial cells."
    Yamaguchi S.
    Kokubyo Gakkai Zasshi 62:78-93(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT LEU-115.
    Tissue: Uterine ectocervix.
  2. "Functional expression of the human hZIP2 zinc transporter."
    Gaither L.A., Eide D.J.
    J. Biol. Chem. 275:5560-5564(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), CHARACTERIZATION, VARIANT LEU-115.
    Tissue: Prostate.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Prostate.
  4. "The DNA sequence and analysis of human chromosome 14."
    Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H.
    , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J.
    Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT LEU-115.
  6. "Expression of zinc transporters in human prostate."
    Nong G., Buszko M.L., Sweeney C.A., Furman J., Rice L.P.
    Submitted (APR-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 183-242 (ISOFORM 1).
    Tissue: Prostate.

Entry informationi

Entry nameiS39A2_HUMAN
AccessioniPrimary (citable) accession number: Q9NP94
Secondary accession number(s): B2RC76
, G3V5X2, Q4QQJ1, Q4V9S4, Q96JT6, Q9UD20
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 26, 2003
Last sequence update: May 18, 2010
Last modified: September 3, 2014
This is version 101 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Zinc uptake is inhibited at pH levels below 7.0 and is stimulated at higher pH and is significantly inhibited by Cu2+, Co2+ and Mn2+ ions. Not inhibited by Fe2+.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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