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Q9NP92

- RT30_HUMAN

UniProt

Q9NP92 - RT30_HUMAN

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Protein

28S ribosomal protein S30, mitochondrial

Gene

MRPS30

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. poly(A) RNA binding Source: UniProtKB
  2. structural constituent of ribosome Source: InterPro

GO - Biological processi

  1. apoptotic process Source: ProtInc
  2. translation Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiREACT_267602. Mitochondrial translation termination.
REACT_267677. Mitochondrial translation elongation.
REACT_267680. Mitochondrial translation initiation.

Names & Taxonomyi

Protein namesi
Recommended name:
28S ribosomal protein S30, mitochondrial
Short name:
MRP-S30
Short name:
S30mt
Alternative name(s):
Programmed cell death protein 9
Gene namesi
Name:MRPS30
Synonyms:PDCD9
ORF Names:BM-047
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Unplaced

Organism-specific databases

HGNCiHGNC:8769. MRPS30.

Subcellular locationi

Mitochondrion 1 Publication

GO - Cellular componenti

  1. mitochondrion Source: UniProtKB-KW
  2. ribosome Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA31018.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 43943928S ribosomal protein S30, mitochondrialPRO_0000087720Add
BLAST

Proteomic databases

MaxQBiQ9NP92.
PaxDbiQ9NP92.
PeptideAtlasiQ9NP92.
PRIDEiQ9NP92.

PTM databases

PhosphoSiteiQ9NP92.

Expressioni

Tissue specificityi

Heart, skeletal muscle, kidney and liver. Lower expression in placenta and peripheral blood leukocytes.2 Publications

Gene expression databases

BgeeiQ9NP92.
CleanExiHS_MRPS30.
GenevestigatoriQ9NP92.

Organism-specific databases

HPAiHPA018686.
HPA021149.

Interactioni

Subunit structurei

Component of the mitochondrial ribosome small subunit (28S) which comprises a 12S rRNA and about 30 distinct proteins.

Protein-protein interaction databases

BioGridi116091. 69 interactions.
IntActiQ9NP92. 2 interactions.
MINTiMINT-8052234.
STRINGi9606.ENSP00000230914.

Structurei

3D structure databases

ProteinModelPortaliQ9NP92.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ribosomal protein S30/L37 family.Curated

Phylogenomic databases

eggNOGiNOG241777.
GeneTreeiENSGT00390000001442.
HOGENOMiHOG000059255.
HOVERGENiHBG036127.
InParanoidiQ9NP92.
KOiK17409.
OMAiARYPPIV.
OrthoDBiEOG7SR4M3.
PhylomeDBiQ9NP92.
TreeFamiTF320686.

Family and domain databases

InterProiIPR010793. Ribosomal_L37/S30.
[Graphical view]
PfamiPF07147. PDCD9. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9NP92-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAAARCWRPL LRGPRLSLHT AANAAATATE TTCQDVAATP VARYPPIVAS
60 70 80 90 100
MTADSKAARL RRIERWQATV HAAESVDEKL RILTKMQFMK YMVYPQTFAL
110 120 130 140 150
NADRWYQYFT KTVFLSGLPP PPAEPEPEPE PEPEPALDLA ALRAVACDCL
160 170 180 190 200
LQEHFYLRRR RRVHRYEESE VISLPFLDQL VSTLVGLLSP HNPALAAAAL
210 220 230 240 250
DYRCPVHFYW VRGEEIIPRG HRRGRIDDLR YQIDDKPNNQ IRISKQLAEF
260 270 280 290 300
VPLDYSVPIE IPTIKCKPDK LPLFKRQYEN HIFVGSKTAD PCCYGHTQFH
310 320 330 340 350
LLPDKLRRER LLRQNCADQI EVVFRANAIA SLFAWTGAQA MYQGFWSEAD
360 370 380 390 400
VTRPFVSQAV ITDGKYFSFF CYQLNTLALT TQADQNNPRK NICWGTQSKP
410 420 430
LYETIEDNDV KGFNDDVLLQ IVHFLLNRPK EEKSQLLEN
Length:439
Mass (Da):50,365
Last modified:October 17, 2006 - v2
Checksum:i2A22DB6170F6D04F
GO

Sequence cautioni

The sequence AAF67634.1 differs from that shown. Reason: Sequencing errors.Curated
The sequence AAF67634.1 differs from that shown. Reason: Frameshift at several positions. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti82 – 821I → V in CAB66641. (PubMed:11230166)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti33 – 331C → S.3 Publications
Corresponds to variant rs3747479 [ dbSNP | Ensembl ].
VAR_028023
Natural varianti102 – 1021A → V.
Corresponds to variant rs35601455 [ dbSNP | Ensembl ].
VAR_052048

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF146192 mRNA. Translation: AAF65227.1.
AL355715 mRNA. Translation: CAB90810.1.
AL355716 mRNA. Translation: CAB90811.1.
AL136706 mRNA. Translation: CAB66641.1.
AK074777 mRNA. Translation: BAC11202.1.
BC007735 mRNA. Translation: AAH07735.1.
AF217523 mRNA. Translation: AAF67634.1. Sequence problems.
AB061211 Genomic DNA. Translation: BAB54961.1.
CCDSiCCDS3951.1.
RefSeqiNP_057724.2. NM_016640.3.
UniGeneiHs.124165.

Genome annotation databases

GeneIDi10884.
KEGGihsa:10884.
UCSCiuc003joh.3. human.

Polymorphism databases

DMDMi116242771.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF146192 mRNA. Translation: AAF65227.1 .
AL355715 mRNA. Translation: CAB90810.1 .
AL355716 mRNA. Translation: CAB90811.1 .
AL136706 mRNA. Translation: CAB66641.1 .
AK074777 mRNA. Translation: BAC11202.1 .
BC007735 mRNA. Translation: AAH07735.1 .
AF217523 mRNA. Translation: AAF67634.1 . Sequence problems.
AB061211 Genomic DNA. Translation: BAB54961.1 .
CCDSi CCDS3951.1.
RefSeqi NP_057724.2. NM_016640.3.
UniGenei Hs.124165.

3D structure databases

ProteinModelPortali Q9NP92.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 116091. 69 interactions.
IntActi Q9NP92. 2 interactions.
MINTi MINT-8052234.
STRINGi 9606.ENSP00000230914.

PTM databases

PhosphoSitei Q9NP92.

Polymorphism databases

DMDMi 116242771.

Proteomic databases

MaxQBi Q9NP92.
PaxDbi Q9NP92.
PeptideAtlasi Q9NP92.
PRIDEi Q9NP92.

Protocols and materials databases

DNASUi 10884.
Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 10884.
KEGGi hsa:10884.
UCSCi uc003joh.3. human.

Organism-specific databases

CTDi 10884.
GeneCardsi GC05P044809.
HGNCi HGNC:8769. MRPS30.
HPAi HPA018686.
HPA021149.
MIMi 611991. gene.
neXtProti NX_Q9NP92.
PharmGKBi PA31018.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG241777.
GeneTreei ENSGT00390000001442.
HOGENOMi HOG000059255.
HOVERGENi HBG036127.
InParanoidi Q9NP92.
KOi K17409.
OMAi ARYPPIV.
OrthoDBi EOG7SR4M3.
PhylomeDBi Q9NP92.
TreeFami TF320686.

Enzyme and pathway databases

Reactomei REACT_267602. Mitochondrial translation termination.
REACT_267677. Mitochondrial translation elongation.
REACT_267680. Mitochondrial translation initiation.

Miscellaneous databases

ChiTaRSi MRPS30. human.
GeneWikii MRPS30.
GenomeRNAii 10884.
NextBioi 41327.
PROi Q9NP92.
SOURCEi Search...

Gene expression databases

Bgeei Q9NP92.
CleanExi HS_MRPS30.
Genevestigatori Q9NP92.

Family and domain databases

InterProi IPR010793. Ribosomal_L37/S30.
[Graphical view ]
Pfami PF07147. PDCD9. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning, expression, and mapping of PDCD9, the human homolog of Gallus gallus pro-apoptotic protein p52."
    Carim-Todd L., Sumoy L., Nadal M., Estivill X., Escarceller M.
    Cytogenet. Cell Genet. 87:85-88(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, VARIANT SER-33.
  2. The European IMAGE consortium
    Submitted (MAY-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT SER-33.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT SER-33.
    Tissue: Kidney.
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Teratocarcinoma.
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Muscle.
  6. "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells."
    Zhang Q.-H., Ye M., Wu X.-Y., Ren S.-X., Zhao M., Zhao C.-J., Fu G., Shen Y., Fan H.-Y., Lu G., Zhong M., Xu X.-R., Han Z.-G., Zhang J.-W., Tao J., Huang Q.-H., Zhou J., Hu G.-X.
    , Gu J., Chen S.-J., Chen Z.
    Genome Res. 10:1546-1560(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 89-439.
    Tissue: Bone marrow.
  7. "The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders."
    Kenmochi N., Suzuki T., Uechi T., Magoori M., Kuniba M., Higa S., Watanabe K., Tanaka T.
    Genomics 77:65-70(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 275-284.
  8. "The small subunit of the mammalian mitochondrial ribosome: identification of the full complement of ribosomal proteins present."
    Koc E.C., Burkhart W., Blackburn K., Moseley A., Spremulli L.L.
    J. Biol. Chem. 276:19363-19374(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION.
  9. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiRT30_HUMAN
AccessioniPrimary (citable) accession number: Q9NP92
Secondary accession number(s): Q96I91
, Q96Q19, Q9H0P8, Q9NSF9, Q9NZ76
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 19, 2002
Last sequence update: October 17, 2006
Last modified: November 26, 2014
This is version 113 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Ribosomal proteins
    Ribosomal proteins families and list of entries
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3