Q9NP92 (RT30_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
28S ribosomal protein S30, mitochondrial
Short name=MRP-S30
Short name=S30mt

Alternative name(s):
Programmed cell death protein 9

Gene names

Name:	MRPS30
Synonyms:	PDCD9
ORF Names:	BM-047

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	439 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Subunit structure	Component of the mitochondrial ribosome small subunit (28S) which comprises a 12S rRNA and about 30 distinct proteins.
Subcellular location	Mitochondrion Ref.8.
Tissue specificity	Heart, skeletal muscle, kidney and liver. Lower expression in placenta and peripheral blood leukocytes. Ref.1 Ref.8
Sequence similarities	Belongs to the ribosomal protein S30/L37 family.
Sequence caution	The sequence AAF67634.1 differs from that shown. Reason: Frameshift at several positions. The sequence AAF67634.1 differs from that shown. Reason: Sequencing errors.

Ontologies

Keywords
Cellular component	Mitochondrion
Coding sequence diversity	Polymorphism
Molecular function	Ribonucleoprotein Ribosomal protein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	apoptotic process Traceable author statement Ref.1. Source: ProtInc translation Inferred from electronic annotation. Source: InterPro
Cellular_component	mitochondrion Inferred from electronic annotation. Source: UniProtKB-SubCell ribosome Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	structural constituent of ribosome Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 439	439	28S ribosomal protein S30, mitochondrial		PRO_0000087720
Natural variations
	Natural variant	33	1	C → S. Ref.1 Ref.2 Ref.3 Corresponds to variant rs3747479 [ dbSNP | Ensembl ].		VAR_028023
	Natural variant	102	1	A → V. Corresponds to variant rs35601455 [ dbSNP | Ensembl ].		VAR_052048
Experimental info
	Sequence conflict	82	1	I → V in CAB66641. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Q9NP92 [UniParc]. Last modified October 17, 2006. Version 2. Checksum: 2A22DB6170F6D04F	FASTA	439	50,365
	10 20 30 40 50 60 MAAARCWRPL LRGPRLSLHT AANAAATATE TTCQDVAATP VARYPPIVAS MTADSKAARL 70 80 90 100 110 120 RRIERWQATV HAAESVDEKL RILTKMQFMK YMVYPQTFAL NADRWYQYFT KTVFLSGLPP 130 140 150 160 170 180 PPAEPEPEPE PEPEPALDLA ALRAVACDCL LQEHFYLRRR RRVHRYEESE VISLPFLDQL 190 200 210 220 230 240 VSTLVGLLSP HNPALAAAAL DYRCPVHFYW VRGEEIIPRG HRRGRIDDLR YQIDDKPNNQ 250 260 270 280 290 300 IRISKQLAEF VPLDYSVPIE IPTIKCKPDK LPLFKRQYEN HIFVGSKTAD PCCYGHTQFH 310 320 330 340 350 360 LLPDKLRRER LLRQNCADQI EVVFRANAIA SLFAWTGAQA MYQGFWSEAD VTRPFVSQAV 370 380 390 400 410 420 ITDGKYFSFF CYQLNTLALT TQADQNNPRK NICWGTQSKP LYETIEDNDV KGFNDDVLLQ 430 IVHFLLNRPK EEKSQLLEN

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning, expression, and mapping of PDCD9, the human homolog of Gallus gallus pro-apoptotic protein p52." Carim-Todd L., Sumoy L., Nadal M., Estivill X., Escarceller M. Cytogenet. Cell Genet. 87:85-88(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, VARIANT SER-33.
[2]	The European IMAGE consortium Submitted (MAY-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT SER-33.
[3]	"Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs." Wiemann S., Weil B., Wellenreuther R., Gassenhuber J., Glassl S., Ansorge W., Boecher M., Bloecker H., Bauersachs S., Blum H., Lauber J., Duesterhoeft A., Beyer A., Koehrer K., Strack N., Mewes H.-W., Ottenwaelder B., Obermaier B. , Tampe J., Heubner D., Wambutt R., Korn B., Klein M., Poustka A. Genome Res. 11:422-435(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT SER-33. Tissue: Kidney.
[4]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Teratocarcinoma.
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Muscle.
[6]	"Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells." Zhang Q.-H., Ye M., Wu X.-Y., Ren S.-X., Zhao M., Zhao C.-J., Fu G., Shen Y., Fan H.-Y., Lu G., Zhong M., Xu X.-R., Han Z.-G., Zhang J.-W., Tao J., Huang Q.-H., Zhou J., Hu G.-X. , Gu J., Chen S.-J., Chen Z. Genome Res. 10:1546-1560(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 89-439. Tissue: Bone marrow.
[7]	"The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders." Kenmochi N., Suzuki T., Uechi T., Magoori M., Kuniba M., Higa S., Watanabe K., Tanaka T. Genomics 77:65-70(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 275-284.
[8]	"The small subunit of the mammalian mitochondrial ribosome: identification of the full complement of ribosomal proteins present." Koc E.C., Burkhart W., Blackburn K., Moseley A., Spremulli L.L. J. Biol. Chem. 276:19363-19374(2001) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION.
[9]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF146192 mRNA. Translation: AAF65227.1. AL355715 mRNA. Translation: CAB90810.1. AL355716 mRNA. Translation: CAB90811.1. AL136706 mRNA. Translation: CAB66641.1. AK074777 mRNA. Translation: BAC11202.1. BC007735 mRNA. Translation: AAH07735.1. AF217523 mRNA. Translation: AAF67634.1. Sequence problems. AB061211 Genomic DNA. Translation: BAB54961.1.
IPI	IPI00010278.
RefSeq	NP_057724.2. NM_016640.3.
UniGene	Hs.124165.
3D structure databases
ProteinModelPortal	Q9NP92.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9NP92. 1 interaction.
MINT	MINT-8052234.
STRING	9606.ENSP00000230914.
PTM databases
PhosphoSite	Q9NP92.
Polymorphism databases
DMDM	116242771.
Proteomic databases
PaxDb	Q9NP92.
PeptideAtlas	Q9NP92.
PRIDE	Q9NP92.
Protocols and materials databases
DNASU	10884.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000507110; ENSP00000424328; ENSG00000112996.
GeneID	10884.
KEGG	hsa:10884.
UCSC	uc003joh.3. human.
Organism-specific databases
CTD	10884.
GeneCards	GC05P044809.
HGNC	HGNC:8769. MRPS30.
HPA	HPA018686. HPA021149.
MIM	611991. gene.
neXtProt	NX_Q9NP92.
PharmGKB	PA31018.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG241777.
HOGENOM	HOG000059255.
HOVERGEN	HBG036127.
InParanoid	Q9NP92.
OMA	FSFFCYQ.
OrthoDB	EOG4MCX0C.
PhylomeDB	Q9NP92.
Gene expression databases
Bgee	Q9NP92.
CleanEx	HS_MRPS30.
Genevestigator	Q9NP92.
GermOnline	ENSG00000112996. Homo sapiens.
Family and domain databases
InterPro	IPR010793. Ribosomal_L37/S30. [Graphical view]
Pfam	PF07147. PDCD9. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	10884.
NextBio	41327.
SOURCE	Search...

Entry information

Entry name

RT30_HUMAN

Accession

Primary (citable) accession number: Q9NP92
Secondary accession number(s): Q96I91 , Q96Q19, Q9H0P8, Q9NSF9, Q9NZ76

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 19, 2002
Last sequence update:	October 17, 2006
Last modified:	May 29, 2013
This is version 102 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.