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Q9NP92

- RT30_HUMAN

UniProt

Q9NP92 - RT30_HUMAN

Protein

28S ribosomal protein S30, mitochondrial

Gene

MRPS30

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 111 (01 Oct 2014)
      Sequence version 2 (17 Oct 2006)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. poly(A) RNA binding Source: UniProtKB
    2. structural constituent of ribosome Source: InterPro

    GO - Biological processi

    1. apoptotic process Source: ProtInc
    2. translation Source: InterPro

    Keywords - Molecular functioni

    Ribonucleoprotein, Ribosomal protein

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    28S ribosomal protein S30, mitochondrial
    Short name:
    MRP-S30
    Short name:
    S30mt
    Alternative name(s):
    Programmed cell death protein 9
    Gene namesi
    Name:MRPS30
    Synonyms:PDCD9
    ORF Names:BM-047
    OrganismiHomo sapiens (Human)Imported
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 5

    Organism-specific databases

    HGNCiHGNC:8769. MRPS30.

    Subcellular locationi

    Mitochondrion 1 Publication

    GO - Cellular componenti

    1. mitochondrion Source: UniProtKB-SubCell
    2. ribosome Source: UniProtKB-KW

    Keywords - Cellular componenti

    Mitochondrion

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA31018.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 43943928S ribosomal protein S30, mitochondrialPRO_0000087720Add
    BLAST

    Proteomic databases

    MaxQBiQ9NP92.
    PaxDbiQ9NP92.
    PeptideAtlasiQ9NP92.
    PRIDEiQ9NP92.

    PTM databases

    PhosphoSiteiQ9NP92.

    Expressioni

    Tissue specificityi

    Heart, skeletal muscle, kidney and liver. Lower expression in placenta and peripheral blood leukocytes.2 Publications

    Gene expression databases

    BgeeiQ9NP92.
    CleanExiHS_MRPS30.
    GenevestigatoriQ9NP92.

    Organism-specific databases

    HPAiHPA018686.
    HPA021149.

    Interactioni

    Subunit structurei

    Component of the mitochondrial ribosome small subunit (28S) which comprises a 12S rRNA and about 30 distinct proteins.

    Protein-protein interaction databases

    BioGridi116091. 6 interactions.
    IntActiQ9NP92. 2 interactions.
    MINTiMINT-8052234.
    STRINGi9606.ENSP00000230914.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9NP92.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ribosomal protein S30/L37 family.Curated

    Phylogenomic databases

    eggNOGiNOG241777.
    HOGENOMiHOG000059255.
    HOVERGENiHBG036127.
    InParanoidiQ9NP92.
    KOiK17409.
    OMAiARYPPIV.
    OrthoDBiEOG7SR4M3.
    PhylomeDBiQ9NP92.
    TreeFamiTF320686.

    Family and domain databases

    InterProiIPR010793. Ribosomal_L37/S30.
    [Graphical view]
    PfamiPF07147. PDCD9. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9NP92-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAAARCWRPL LRGPRLSLHT AANAAATATE TTCQDVAATP VARYPPIVAS    50
    MTADSKAARL RRIERWQATV HAAESVDEKL RILTKMQFMK YMVYPQTFAL 100
    NADRWYQYFT KTVFLSGLPP PPAEPEPEPE PEPEPALDLA ALRAVACDCL 150
    LQEHFYLRRR RRVHRYEESE VISLPFLDQL VSTLVGLLSP HNPALAAAAL 200
    DYRCPVHFYW VRGEEIIPRG HRRGRIDDLR YQIDDKPNNQ IRISKQLAEF 250
    VPLDYSVPIE IPTIKCKPDK LPLFKRQYEN HIFVGSKTAD PCCYGHTQFH 300
    LLPDKLRRER LLRQNCADQI EVVFRANAIA SLFAWTGAQA MYQGFWSEAD 350
    VTRPFVSQAV ITDGKYFSFF CYQLNTLALT TQADQNNPRK NICWGTQSKP 400
    LYETIEDNDV KGFNDDVLLQ IVHFLLNRPK EEKSQLLEN 439
    Length:439
    Mass (Da):50,365
    Last modified:October 17, 2006 - v2
    Checksum:i2A22DB6170F6D04F
    GO

    Sequence cautioni

    The sequence AAF67634.1 differs from that shown. Reason: Sequencing errors.
    The sequence AAF67634.1 differs from that shown. Reason: Frameshift at several positions.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti82 – 821I → V in CAB66641. (PubMed:11230166)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti33 – 331C → S.3 Publications
    Corresponds to variant rs3747479 [ dbSNP | Ensembl ].
    VAR_028023
    Natural varianti102 – 1021A → V.
    Corresponds to variant rs35601455 [ dbSNP | Ensembl ].
    VAR_052048

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF146192 mRNA. Translation: AAF65227.1.
    AL355715 mRNA. Translation: CAB90810.1.
    AL355716 mRNA. Translation: CAB90811.1.
    AL136706 mRNA. Translation: CAB66641.1.
    AK074777 mRNA. Translation: BAC11202.1.
    BC007735 mRNA. Translation: AAH07735.1.
    AF217523 mRNA. Translation: AAF67634.1. Sequence problems.
    AB061211 Genomic DNA. Translation: BAB54961.1.
    CCDSiCCDS3951.1.
    RefSeqiNP_057724.2. NM_016640.3.
    UniGeneiHs.124165.

    Genome annotation databases

    EnsembliENST00000507110; ENSP00000424328; ENSG00000112996.
    GeneIDi10884.
    KEGGihsa:10884.
    UCSCiuc003joh.3. human.

    Polymorphism databases

    DMDMi116242771.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF146192 mRNA. Translation: AAF65227.1 .
    AL355715 mRNA. Translation: CAB90810.1 .
    AL355716 mRNA. Translation: CAB90811.1 .
    AL136706 mRNA. Translation: CAB66641.1 .
    AK074777 mRNA. Translation: BAC11202.1 .
    BC007735 mRNA. Translation: AAH07735.1 .
    AF217523 mRNA. Translation: AAF67634.1 . Sequence problems.
    AB061211 Genomic DNA. Translation: BAB54961.1 .
    CCDSi CCDS3951.1.
    RefSeqi NP_057724.2. NM_016640.3.
    UniGenei Hs.124165.

    3D structure databases

    ProteinModelPortali Q9NP92.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 116091. 6 interactions.
    IntActi Q9NP92. 2 interactions.
    MINTi MINT-8052234.
    STRINGi 9606.ENSP00000230914.

    PTM databases

    PhosphoSitei Q9NP92.

    Polymorphism databases

    DMDMi 116242771.

    Proteomic databases

    MaxQBi Q9NP92.
    PaxDbi Q9NP92.
    PeptideAtlasi Q9NP92.
    PRIDEi Q9NP92.

    Protocols and materials databases

    DNASUi 10884.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000507110 ; ENSP00000424328 ; ENSG00000112996 .
    GeneIDi 10884.
    KEGGi hsa:10884.
    UCSCi uc003joh.3. human.

    Organism-specific databases

    CTDi 10884.
    GeneCardsi GC05P044809.
    HGNCi HGNC:8769. MRPS30.
    HPAi HPA018686.
    HPA021149.
    MIMi 611991. gene.
    neXtProti NX_Q9NP92.
    PharmGKBi PA31018.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG241777.
    HOGENOMi HOG000059255.
    HOVERGENi HBG036127.
    InParanoidi Q9NP92.
    KOi K17409.
    OMAi ARYPPIV.
    OrthoDBi EOG7SR4M3.
    PhylomeDBi Q9NP92.
    TreeFami TF320686.

    Miscellaneous databases

    GeneWikii MRPS30.
    GenomeRNAii 10884.
    NextBioi 41327.
    PROi Q9NP92.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9NP92.
    CleanExi HS_MRPS30.
    Genevestigatori Q9NP92.

    Family and domain databases

    InterProi IPR010793. Ribosomal_L37/S30.
    [Graphical view ]
    Pfami PF07147. PDCD9. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning, expression, and mapping of PDCD9, the human homolog of Gallus gallus pro-apoptotic protein p52."
      Carim-Todd L., Sumoy L., Nadal M., Estivill X., Escarceller M.
      Cytogenet. Cell Genet. 87:85-88(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, VARIANT SER-33.
    2. The European IMAGE consortium
      Submitted (MAY-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT SER-33.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT SER-33.
      Tissue: Kidney.
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Teratocarcinoma.
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Muscle.
    6. "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells."
      Zhang Q.-H., Ye M., Wu X.-Y., Ren S.-X., Zhao M., Zhao C.-J., Fu G., Shen Y., Fan H.-Y., Lu G., Zhong M., Xu X.-R., Han Z.-G., Zhang J.-W., Tao J., Huang Q.-H., Zhou J., Hu G.-X.
      , Gu J., Chen S.-J., Chen Z.
      Genome Res. 10:1546-1560(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 89-439.
      Tissue: Bone marrow.
    7. "The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders."
      Kenmochi N., Suzuki T., Uechi T., Magoori M., Kuniba M., Higa S., Watanabe K., Tanaka T.
      Genomics 77:65-70(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 275-284.
    8. "The small subunit of the mammalian mitochondrial ribosome: identification of the full complement of ribosomal proteins present."
      Koc E.C., Burkhart W., Blackburn K., Moseley A., Spremulli L.L.
      J. Biol. Chem. 276:19363-19374(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION.
    9. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiRT30_HUMAN
    AccessioniPrimary (citable) accession number: Q9NP92
    Secondary accession number(s): Q96I91
    , Q96Q19, Q9H0P8, Q9NSF9, Q9NZ76
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 19, 2002
    Last sequence update: October 17, 2006
    Last modified: October 1, 2014
    This is version 111 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 5
      Human chromosome 5: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. Ribosomal proteins
      Ribosomal proteins families and list of entries
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3