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Protein

39S ribosomal protein S30, mitochondrial

Gene

MRPS30

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • RNA binding Source: UniProtKB
  • structural constituent of ribosome Source: InterPro

GO - Biological processi

  • apoptotic process Source: ProtInc
  • mitochondrial translational elongation Source: Reactome
  • mitochondrial translational termination Source: Reactome

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-HSA-5368286. Mitochondrial translation initiation.
R-HSA-5389840. Mitochondrial translation elongation.
R-HSA-5419276. Mitochondrial translation termination.

Names & Taxonomyi

Protein namesi
Recommended name:
39S ribosomal protein S30, mitochondrial
Short name:
MRP-S30
Short name:
S30mt
Alternative name(s):
Mitochondrial large ribosomal subunit protein mL651 Publication
Mitochondrial large ribosomal subunit protein mS301 Publication
Programmed cell death protein 9
Gene namesi
Name:MRPS30
Synonyms:PDCD9
ORF Names:BM-047
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000112996.9.
HGNCiHGNC:8769. MRPS30.
MIMi611991. gene.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Organism-specific databases

DisGeNETi10884.
OpenTargetsiENSG00000112996.
PharmGKBiPA31018.

Polymorphism and mutation databases

BioMutaiMRPS30.
DMDMi116242771.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000877201 – 43939S ribosomal protein S30, mitochondrialAdd BLAST439

Proteomic databases

EPDiQ9NP92.
MaxQBiQ9NP92.
PaxDbiQ9NP92.
PeptideAtlasiQ9NP92.
PRIDEiQ9NP92.

PTM databases

iPTMnetiQ9NP92.
PhosphoSitePlusiQ9NP92.
SwissPalmiQ9NP92.

Expressioni

Tissue specificityi

Heart, skeletal muscle, kidney and liver. Lower expression in placenta and peripheral blood leukocytes.2 Publications

Gene expression databases

BgeeiENSG00000112996.
CleanExiHS_MRPS30.
GenevisibleiQ9NP92. HS.

Organism-specific databases

HPAiHPA018686.
HPA021149.

Interactioni

Subunit structurei

Component of the mitochondrial large ribosomal subunit (mt-LSU). Mature mammalian 55S mitochondrial ribosomes consist of a small (28S) and a large (39S) subunit. The 28S small subunit contains a 12S ribosomal RNA (12S mt-rRNA) and 30 different proteins. The 39S large subunit contains a 16S rRNA (16S mt-rRNA), a copy of mitochondrial valine transfer RNA (mt-tRNA(Val)), which plays an integral structural role, and 52 different proteins. mL65 forms a heterodimer with mL37.2 Publications

Protein-protein interaction databases

BioGridi116091. 80 interactors.
CORUMiQ9NP92.
IntActiQ9NP92. 15 interactors.
MINTiMINT-8052234.
STRINGi9606.ENSP00000424328.

Structurei

Secondary structure

1439
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi51 – 56Combined sources6
Helixi57 – 71Combined sources15
Helixi76 – 83Combined sources8
Beta strandi90 – 93Combined sources4
Helixi102 – 110Combined sources9
Beta strandi112 – 117Combined sources6
Helixi141 – 154Combined sources14
Helixi168 – 171Combined sources4
Helixi173 – 187Combined sources15
Turni188 – 191Combined sources4
Helixi193 – 196Combined sources4
Beta strandi199 – 203Combined sources5
Beta strandi206 – 211Combined sources6
Turni221 – 224Combined sources4
Beta strandi230 – 235Combined sources6
Beta strandi238 – 242Combined sources5
Helixi268 – 270Combined sources3
Beta strandi274 – 276Combined sources3
Beta strandi283 – 286Combined sources4
Beta strandi297 – 301Combined sources5
Helixi304 – 306Combined sources3
Helixi308 – 313Combined sources6
Helixi319 – 342Combined sources24
Beta strandi347 – 349Combined sources3
Beta strandi355 – 374Combined sources20
Turni381 – 383Combined sources3
Beta strandi384 – 386Combined sources3
Beta strandi391 – 395Combined sources5
Beta strandi399 – 401Combined sources3
Beta strandi403 – 405Combined sources3
Beta strandi407 – 412Combined sources6
Helixi416 – 425Combined sources10

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3J7Yelectron microscopy3.40s1-439[»]
3J9Melectron microscopy3.50s1-439[»]
5OOLelectron microscopy3.06s1-439[»]
5OOMelectron microscopy3.03s1-439[»]
ProteinModelPortaliQ9NP92.
SMRiQ9NP92.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG4461. Eukaryota.
ENOG410ZG5G. LUCA.
GeneTreeiENSGT00390000001442.
HOGENOMiHOG000059255.
HOVERGENiHBG036127.
InParanoidiQ9NP92.
KOiK17409.
OMAiTQHYTRT.
OrthoDBiEOG091G08N8.
PhylomeDBiQ9NP92.
TreeFamiTF320686.

Family and domain databases

InterProiView protein in InterPro
IPR010793. Ribosomal_L37/S30.
PfamiView protein in Pfam
PF07147. PDCD9. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9NP92-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAARCWRPL LRGPRLSLHT AANAAATATE TTCQDVAATP VARYPPIVAS
60 70 80 90 100
MTADSKAARL RRIERWQATV HAAESVDEKL RILTKMQFMK YMVYPQTFAL
110 120 130 140 150
NADRWYQYFT KTVFLSGLPP PPAEPEPEPE PEPEPALDLA ALRAVACDCL
160 170 180 190 200
LQEHFYLRRR RRVHRYEESE VISLPFLDQL VSTLVGLLSP HNPALAAAAL
210 220 230 240 250
DYRCPVHFYW VRGEEIIPRG HRRGRIDDLR YQIDDKPNNQ IRISKQLAEF
260 270 280 290 300
VPLDYSVPIE IPTIKCKPDK LPLFKRQYEN HIFVGSKTAD PCCYGHTQFH
310 320 330 340 350
LLPDKLRRER LLRQNCADQI EVVFRANAIA SLFAWTGAQA MYQGFWSEAD
360 370 380 390 400
VTRPFVSQAV ITDGKYFSFF CYQLNTLALT TQADQNNPRK NICWGTQSKP
410 420 430
LYETIEDNDV KGFNDDVLLQ IVHFLLNRPK EEKSQLLEN
Length:439
Mass (Da):50,365
Last modified:October 17, 2006 - v2
Checksum:i2A22DB6170F6D04F
GO

Sequence cautioni

The sequence AAF67634 differs from that shown. Sequencing errors.Curated
The sequence AAF67634 differs from that shown. Reason: Frameshift at several positions.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti82I → V in CAB66641 (PubMed:11230166).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02802333C → S3 PublicationsCorresponds to variant dbSNP:rs3747479Ensembl.1
Natural variantiVAR_052048102A → V. Corresponds to variant dbSNP:rs35601455Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF146192 mRNA. Translation: AAF65227.1.
AL355715 mRNA. Translation: CAB90810.1.
AL355716 mRNA. Translation: CAB90811.1.
AL136706 mRNA. Translation: CAB66641.1.
AK074777 mRNA. Translation: BAC11202.1.
BC007735 mRNA. Translation: AAH07735.1.
AF217523 mRNA. Translation: AAF67634.1. Sequence problems.
AB061211 Genomic DNA. Translation: BAB54961.1.
CCDSiCCDS3951.1.
RefSeqiNP_057724.2. NM_016640.3.
UniGeneiHs.124165.

Genome annotation databases

EnsembliENST00000507110; ENSP00000424328; ENSG00000112996.
GeneIDi10884.
KEGGihsa:10884.
UCSCiuc003joh.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiRT30_HUMAN
AccessioniPrimary (citable) accession number: Q9NP92
Secondary accession number(s): Q96I91
, Q96Q19, Q9H0P8, Q9NSF9, Q9NZ76
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 19, 2002
Last sequence update: October 17, 2006
Last modified: November 22, 2017
This is version 142 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Ribosomal proteins
    Ribosomal proteins families and list of entries
  7. SIMILARITY comments
    Index of protein domains and families