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Q9NP92 (RT30_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 110. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
28S ribosomal protein S30, mitochondrial

Short name=MRP-S30
Short name=S30mt
Alternative name(s):
Programmed cell death protein 9
Gene names
Name:MRPS30
Synonyms:PDCD9
ORF Names:BM-047
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length439 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Subunit structure

Component of the mitochondrial ribosome small subunit (28S) which comprises a 12S rRNA and about 30 distinct proteins.

Subcellular location

Mitochondrion Ref.8.

Tissue specificity

Heart, skeletal muscle, kidney and liver. Lower expression in placenta and peripheral blood leukocytes. Ref.1 Ref.8

Sequence similarities

Belongs to the ribosomal protein S30/L37 family.

Sequence caution

The sequence AAF67634.1 differs from that shown. Reason: Frameshift at several positions.

The sequence AAF67634.1 differs from that shown. Reason: Sequencing errors.

Ontologies

Keywords
   Cellular componentMitochondrion
   Coding sequence diversityPolymorphism
   Molecular functionRibonucleoprotein
Ribosomal protein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processapoptotic process

Traceable author statement Ref.1. Source: ProtInc

translation

Inferred from electronic annotation. Source: InterPro

   Cellular_componentmitochondrion

Inferred from electronic annotation. Source: UniProtKB-SubCell

ribosome

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionpoly(A) RNA binding

Inferred from direct assay PubMed 22658674. Source: UniProtKB

structural constituent of ribosome

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 43943928S ribosomal protein S30, mitochondrial
PRO_0000087720

Natural variations

Natural variant331C → S. Ref.1 Ref.2 Ref.3
Corresponds to variant rs3747479 [ dbSNP | Ensembl ].
VAR_028023
Natural variant1021A → V.
Corresponds to variant rs35601455 [ dbSNP | Ensembl ].
VAR_052048

Experimental info

Sequence conflict821I → V in CAB66641. Ref.3

Sequences

Sequence LengthMass (Da)Tools
Q9NP92 [UniParc].

Last modified October 17, 2006. Version 2.
Checksum: 2A22DB6170F6D04F

FASTA43950,365
        10         20         30         40         50         60 
MAAARCWRPL LRGPRLSLHT AANAAATATE TTCQDVAATP VARYPPIVAS MTADSKAARL 

        70         80         90        100        110        120 
RRIERWQATV HAAESVDEKL RILTKMQFMK YMVYPQTFAL NADRWYQYFT KTVFLSGLPP 

       130        140        150        160        170        180 
PPAEPEPEPE PEPEPALDLA ALRAVACDCL LQEHFYLRRR RRVHRYEESE VISLPFLDQL 

       190        200        210        220        230        240 
VSTLVGLLSP HNPALAAAAL DYRCPVHFYW VRGEEIIPRG HRRGRIDDLR YQIDDKPNNQ 

       250        260        270        280        290        300 
IRISKQLAEF VPLDYSVPIE IPTIKCKPDK LPLFKRQYEN HIFVGSKTAD PCCYGHTQFH 

       310        320        330        340        350        360 
LLPDKLRRER LLRQNCADQI EVVFRANAIA SLFAWTGAQA MYQGFWSEAD VTRPFVSQAV 

       370        380        390        400        410        420 
ITDGKYFSFF CYQLNTLALT TQADQNNPRK NICWGTQSKP LYETIEDNDV KGFNDDVLLQ 

       430 
IVHFLLNRPK EEKSQLLEN 

« Hide

References

« Hide 'large scale' references
[1]"Cloning, expression, and mapping of PDCD9, the human homolog of Gallus gallus pro-apoptotic protein p52."
Carim-Todd L., Sumoy L., Nadal M., Estivill X., Escarceller M.
Cytogenet. Cell Genet. 87:85-88(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, VARIANT SER-33.
[2]The European IMAGE consortium
Submitted (MAY-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT SER-33.
[3]"Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs."
Wiemann S., Weil B., Wellenreuther R., Gassenhuber J., Glassl S., Ansorge W., Boecher M., Bloecker H., Bauersachs S., Blum H., Lauber J., Duesterhoeft A., Beyer A., Koehrer K., Strack N., Mewes H.-W., Ottenwaelder B., Obermaier B. expand/collapse author list , Tampe J., Heubner D., Wambutt R., Korn B., Klein M., Poustka A.
Genome Res. 11:422-435(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT SER-33.
Tissue: Kidney.
[4]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Teratocarcinoma.
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Muscle.
[6]"Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells."
Zhang Q.-H., Ye M., Wu X.-Y., Ren S.-X., Zhao M., Zhao C.-J., Fu G., Shen Y., Fan H.-Y., Lu G., Zhong M., Xu X.-R., Han Z.-G., Zhang J.-W., Tao J., Huang Q.-H., Zhou J., Hu G.-X. expand/collapse author list , Gu J., Chen S.-J., Chen Z.
Genome Res. 10:1546-1560(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 89-439.
Tissue: Bone marrow.
[7]"The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders."
Kenmochi N., Suzuki T., Uechi T., Magoori M., Kuniba M., Higa S., Watanabe K., Tanaka T.
Genomics 77:65-70(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 275-284.
[8]"The small subunit of the mammalian mitochondrial ribosome: identification of the full complement of ribosomal proteins present."
Koc E.C., Burkhart W., Blackburn K., Moseley A., Spremulli L.L.
J. Biol. Chem. 276:19363-19374(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION.
[9]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF146192 mRNA. Translation: AAF65227.1.
AL355715 mRNA. Translation: CAB90810.1.
AL355716 mRNA. Translation: CAB90811.1.
AL136706 mRNA. Translation: CAB66641.1.
AK074777 mRNA. Translation: BAC11202.1.
BC007735 mRNA. Translation: AAH07735.1.
AF217523 mRNA. Translation: AAF67634.1. Sequence problems.
AB061211 Genomic DNA. Translation: BAB54961.1.
CCDSCCDS3951.1.
RefSeqNP_057724.2. NM_016640.3.
UniGeneHs.124165.

3D structure databases

ProteinModelPortalQ9NP92.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid116091. 6 interactions.
IntActQ9NP92. 2 interactions.
MINTMINT-8052234.
STRING9606.ENSP00000230914.

PTM databases

PhosphoSiteQ9NP92.

Polymorphism databases

DMDM116242771.

Proteomic databases

MaxQBQ9NP92.
PaxDbQ9NP92.
PeptideAtlasQ9NP92.
PRIDEQ9NP92.

Protocols and materials databases

DNASU10884.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000507110; ENSP00000424328; ENSG00000112996.
GeneID10884.
KEGGhsa:10884.
UCSCuc003joh.3. human.

Organism-specific databases

CTD10884.
GeneCardsGC05P044809.
HGNCHGNC:8769. MRPS30.
HPAHPA018686.
HPA021149.
MIM611991. gene.
neXtProtNX_Q9NP92.
PharmGKBPA31018.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG241777.
HOGENOMHOG000059255.
HOVERGENHBG036127.
InParanoidQ9NP92.
KOK17409.
OMAARYPPIV.
OrthoDBEOG7SR4M3.
PhylomeDBQ9NP92.
TreeFamTF320686.

Gene expression databases

BgeeQ9NP92.
CleanExHS_MRPS30.
GenevestigatorQ9NP92.

Family and domain databases

InterProIPR010793. Ribosomal_L37/S30.
[Graphical view]
PfamPF07147. PDCD9. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiMRPS30.
GenomeRNAi10884.
NextBio41327.
PROQ9NP92.
SOURCESearch...

Entry information

Entry nameRT30_HUMAN
AccessionPrimary (citable) accession number: Q9NP92
Secondary accession number(s): Q96I91 expand/collapse secondary AC list , Q96Q19, Q9H0P8, Q9NSF9, Q9NZ76
Entry history
Integrated into UniProtKB/Swiss-Prot: October 19, 2002
Last sequence update: October 17, 2006
Last modified: July 9, 2014
This is version 110 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Ribosomal proteins

Ribosomal proteins families and list of entries

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 5

Human chromosome 5: entries, gene names and cross-references to MIM