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Protein

Ras-related protein Rab-9B

Gene

RAB9B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the transport of proteins between the endosomes and the trans Golgi network.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei65GTP; via amide nitrogenCombined sources1 Publication1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi14 – 22GTPCombined sources1 Publication9
Nucleotide bindingi33 – 34GTPCombined sources1 Publication2
Nucleotide bindingi38 – 39GTPCombined sources1 Publication2
Nucleotide bindingi124 – 127GTPCombined sources1 Publication4
Nucleotide bindingi155 – 156GTPCombined sources1 Publication2

GO - Molecular functioni

  • GDP binding Source: UniProtKB
  • GTP binding Source: UniProtKB-KW

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000123570-MONOMER.
ReactomeiR-HSA-6798695. Neutrophil degranulation.
R-HSA-6811440. Retrograde transport at the Trans-Golgi-Network.
R-HSA-8876198. RAB GEFs exchange GTP for GDP on RABs.

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-related protein Rab-9B
Alternative name(s):
Rab-9-like protein
Short name:
Rab-9L
Gene namesi
Name:RAB9B
Synonyms:RAB9L
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:14090. RAB9B.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: GOC
  • phagocytic vesicle Source: UniProtKB
  • phagocytic vesicle membrane Source: UniProtKB-SubCell
  • plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasmic vesicle, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000123570.
PharmGKBiPA34153.

Polymorphism and mutation databases

BioMutaiRAB9B.
DMDMi13124471.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001211421 – 201Ras-related protein Rab-9BAdd BLAST201

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei34PhosphoserineBy similarity1
Lipidationi200S-geranylgeranyl cysteineBy similarity1
Lipidationi201S-geranylgeranyl cysteineBy similarity1

Keywords - PTMi

Lipoprotein, Phosphoprotein, Prenylation

Proteomic databases

EPDiQ9NP90.
MaxQBiQ9NP90.
PaxDbiQ9NP90.
PeptideAtlasiQ9NP90.
PRIDEiQ9NP90.

PTM databases

iPTMnetiQ9NP90.
PhosphoSitePlusiQ9NP90.

Expressioni

Tissue specificityi

Ubiquitous.1 Publication

Gene expression databases

BgeeiENSG00000123570.
CleanExiHS_RAB9B.
GenevisibleiQ9NP90. HS.

Organism-specific databases

HPAiHPA061932.

Interactioni

Subunit structurei

Interacts (GTP-bound form) with SGSM1; the GDP-bound form has much lower affinity for SGSM1 (PubMed:22637480). The GTP-bound form but not the GDP-bound form interacts with HPS4 and the BLOC-3 complex (heterodimer of HPS1 and HPS4) but does not interact with HPS1 alone (PubMed:20048159).2 Publications

Protein-protein interaction databases

BioGridi119382. 11 interactors.
IntActiQ9NP90. 1 interactor.
STRINGi9606.ENSP00000243298.

Structurei

Secondary structure

1201
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi6 – 13Combined sources8
Helixi20 – 29Combined sources10
Beta strandi41 – 53Combined sources13
Beta strandi55 – 63Combined sources9
Helixi67 – 69Combined sources3
Helixi70 – 73Combined sources4
Helixi74 – 76Combined sources3
Beta strandi81 – 88Combined sources8
Helixi92 – 96Combined sources5
Helixi98 – 108Combined sources11
Turni114 – 116Combined sources3
Beta strandi119 – 124Combined sources6
Helixi135 – 144Combined sources10
Beta strandi150 – 152Combined sources3
Turni155 – 158Combined sources4
Helixi161 – 173Combined sources13

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2OCBX-ray2.20A2-180[»]
ProteinModelPortaliQ9NP90.
SMRiQ9NP90.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9NP90.

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi36 – 44Effector regionBy similarity9

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rab family.Curated

Phylogenomic databases

eggNOGiKOG0394. Eukaryota.
ENOG410XNZV. LUCA.
GeneTreeiENSGT00760000119125.
HOGENOMiHOG000233968.
HOVERGENiHBG009351.
InParanoidiQ9NP90.
KOiK07900.
OMAiLSNWQKE.
OrthoDBiEOG091G0JIV.
PhylomeDBiQ9NP90.
TreeFamiTF326442.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51419. RAB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9NP90-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGKSLLLKV ILLGDGGVGK SSLMNRYVTN KFDSQAFHTI GVEFLNRDLE
60 70 80 90 100
VDGRFVTLQI WDTAGQERFK SLRTPFYRGA DCCLLTFSVD DRQSFENLGN
110 120 130 140 150
WQKEFIYYAD VKDPEHFPFV VLGNKVDKED RQVTTEEAQT WCMENGDYPY
160 170 180 190 200
LETSAKDDTN VTVAFEEAVR QVLAVEEQLE HCMLGHTIDL NSGSKAGSSC

C
Length:201
Mass (Da):22,719
Last modified:October 1, 2000 - v1
Checksum:iB35EDA8E8358C49C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB036693 mRNA. Translation: BAA89542.1.
AK313425 mRNA. Translation: BAG36217.1.
AL139228 Genomic DNA. Translation: CAB76967.1.
BC093756 mRNA. Translation: AAH93756.1.
BC093758 mRNA. Translation: AAH93758.1.
CCDSiCCDS14515.1.
RefSeqiNP_057454.1. NM_016370.2.
UniGeneiHs.522736.

Genome annotation databases

EnsembliENST00000243298; ENSP00000243298; ENSG00000123570.
GeneIDi51209.
KEGGihsa:51209.
UCSCiuc004ell.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB036693 mRNA. Translation: BAA89542.1.
AK313425 mRNA. Translation: BAG36217.1.
AL139228 Genomic DNA. Translation: CAB76967.1.
BC093756 mRNA. Translation: AAH93756.1.
BC093758 mRNA. Translation: AAH93758.1.
CCDSiCCDS14515.1.
RefSeqiNP_057454.1. NM_016370.2.
UniGeneiHs.522736.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2OCBX-ray2.20A2-180[»]
ProteinModelPortaliQ9NP90.
SMRiQ9NP90.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119382. 11 interactors.
IntActiQ9NP90. 1 interactor.
STRINGi9606.ENSP00000243298.

PTM databases

iPTMnetiQ9NP90.
PhosphoSitePlusiQ9NP90.

Polymorphism and mutation databases

BioMutaiRAB9B.
DMDMi13124471.

Proteomic databases

EPDiQ9NP90.
MaxQBiQ9NP90.
PaxDbiQ9NP90.
PeptideAtlasiQ9NP90.
PRIDEiQ9NP90.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000243298; ENSP00000243298; ENSG00000123570.
GeneIDi51209.
KEGGihsa:51209.
UCSCiuc004ell.3. human.

Organism-specific databases

CTDi51209.
GeneCardsiRAB9B.
HGNCiHGNC:14090. RAB9B.
HPAiHPA061932.
MIMi300285. gene.
neXtProtiNX_Q9NP90.
OpenTargetsiENSG00000123570.
PharmGKBiPA34153.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0394. Eukaryota.
ENOG410XNZV. LUCA.
GeneTreeiENSGT00760000119125.
HOGENOMiHOG000233968.
HOVERGENiHBG009351.
InParanoidiQ9NP90.
KOiK07900.
OMAiLSNWQKE.
OrthoDBiEOG091G0JIV.
PhylomeDBiQ9NP90.
TreeFamiTF326442.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000123570-MONOMER.
ReactomeiR-HSA-6798695. Neutrophil degranulation.
R-HSA-6811440. Retrograde transport at the Trans-Golgi-Network.
R-HSA-8876198. RAB GEFs exchange GTP for GDP on RABs.

Miscellaneous databases

EvolutionaryTraceiQ9NP90.
GenomeRNAii51209.
PROiQ9NP90.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000123570.
CleanExiHS_RAB9B.
GenevisibleiQ9NP90. HS.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51419. RAB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRAB9B_HUMAN
AccessioniPrimary (citable) accession number: Q9NP90
Secondary accession number(s): B2R8M0, Q52LX2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: October 1, 2000
Last modified: November 30, 2016
This is version 147 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.