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Protein

Calcium-binding protein 5

Gene

CABP5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Inhibits calcium-dependent inactivation of L-type calcium channel and shifts voltage dependence of activation to more depolarized membrane potentials. Involved in the transmission of light signals (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Calcium bindingi41 – 52121PROSITE-ProRule annotationAdd
BLAST
Calcium bindingi118 – 129122PROSITE-ProRule annotationAdd
BLAST
Calcium bindingi155 – 166123PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  • calcium ion binding Source: UniProtKB

GO - Biological processi

  • signal transduction Source: UniProtKB
Complete GO annotation...

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Calcium-binding protein 5
Short name:
CaBP5
Gene namesi
Name:CABP5
Synonyms:CABP3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:13714. CABP5.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA26004.

Polymorphism and mutation databases

BioMutaiCABP5.
DMDMi13431356.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 173173Calcium-binding protein 5PRO_0000073524Add
BLAST

Proteomic databases

PaxDbiQ9NP86.
PRIDEiQ9NP86.

Expressioni

Tissue specificityi

Retina.1 Publication

Gene expression databases

BgeeiQ9NP86.
CleanExiHS_CABP5.
GenevisibleiQ9NP86. HS.

Organism-specific databases

HPAiHPA043698.

Interactioni

Subunit structurei

Interacts with CACNA1C (via C-terminal CDB motif) in a calcium-dependent manner.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
CEP76Q8TAP63EBI-10311131,EBI-742887
INCA1Q0VD863EBI-10311131,EBI-6509505
RELQ048643EBI-10311131,EBI-307352
TCF4P158843EBI-10311131,EBI-533224
ZKSCAN4Q969J23EBI-10311131,EBI-2818641

Protein-protein interaction databases

BioGridi121142. 7 interactions.
IntActiQ9NP86. 6 interactions.
STRINGi9606.ENSP00000293255.

Structurei

3D structure databases

ProteinModelPortaliQ9NP86.
SMRiQ9NP86. Positions 22-173.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini28 – 6336EF-hand 1PROSITE-ProRule annotationAdd
BLAST
Domaini64 – 9936EF-hand 2PROSITE-ProRule annotationAdd
BLAST
Domaini105 – 14036EF-hand 3PROSITE-ProRule annotationAdd
BLAST
Domaini142 – 17332EF-hand 4PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 4 EF-hand domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0027. Eukaryota.
COG5126. LUCA.
GeneTreeiENSGT00760000118901.
HOGENOMiHOG000233018.
HOVERGENiHBG012180.
InParanoidiQ9NP86.
OMAiTEMELTE.
OrthoDBiEOG7XM303.
PhylomeDBiQ9NP86.
TreeFamiTF334804.

Family and domain databases

Gene3Di1.10.238.10. 2 hits.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
[Graphical view]
PfamiPF13499. EF-hand_7. 2 hits.
[Graphical view]
SMARTiSM00054. EFh. 3 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS00018. EF_HAND_1. 3 hits.
PS50222. EF_HAND_2. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9NP86-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQFPMGPACI FLRKGIAEKQ RERPLGQDEI EELREAFLEF DKDRDGFISC
60 70 80 90 100
KDLGNLMRTM GYMPTEMELI ELGQQIRMNL GGRVDFDDFV ELMTPKLLAE
110 120 130 140 150
TAGMIGVQEM RDAFKEFDTN GDGEITLVEL QQAMQRLLGE RLTPREISEV
160 170
VREADVNGDG TVDFEEFVKM MSR
Length:173
Mass (Da):19,826
Last modified:October 1, 2000 - v1
Checksum:iBB4DD28E9ECC55AF
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti65 – 651T → R.
Corresponds to variant rs34862923 [ dbSNP | Ensembl ].
VAR_033695
Natural varianti80 – 801L → P.
Corresponds to variant rs8105198 [ dbSNP | Ensembl ].
VAR_048633
Natural varianti128 – 1281V → A.
Corresponds to variant rs3745746 [ dbSNP | Ensembl ].
VAR_020020
Natural varianti140 – 1401E → K.
Corresponds to variant rs34681062 [ dbSNP | Ensembl ].
VAR_048634
Natural varianti147 – 1471I → S.
Corresponds to variant rs10425606 [ dbSNP | Ensembl ].
VAR_048635

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF170815
, AF170812, AF170813, AF170814 Genomic DNA. Translation: AAF25798.1.
AF169159 mRNA. Translation: AAF25793.1.
BC126133 mRNA. Translation: AAI26134.1.
BC126135 mRNA. Translation: AAI26136.1.
CCDSiCCDS12709.1.
RefSeqiNP_062829.1. NM_019855.4.
UniGeneiHs.117694.

Genome annotation databases

EnsembliENST00000293255; ENSP00000293255; ENSG00000105507.
GeneIDi56344.
KEGGihsa:56344.
UCSCiuc002phu.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF170815
, AF170812, AF170813, AF170814 Genomic DNA. Translation: AAF25798.1.
AF169159 mRNA. Translation: AAF25793.1.
BC126133 mRNA. Translation: AAI26134.1.
BC126135 mRNA. Translation: AAI26136.1.
CCDSiCCDS12709.1.
RefSeqiNP_062829.1. NM_019855.4.
UniGeneiHs.117694.

3D structure databases

ProteinModelPortaliQ9NP86.
SMRiQ9NP86. Positions 22-173.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121142. 7 interactions.
IntActiQ9NP86. 6 interactions.
STRINGi9606.ENSP00000293255.

Polymorphism and mutation databases

BioMutaiCABP5.
DMDMi13431356.

Proteomic databases

PaxDbiQ9NP86.
PRIDEiQ9NP86.

Protocols and materials databases

DNASUi56344.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000293255; ENSP00000293255; ENSG00000105507.
GeneIDi56344.
KEGGihsa:56344.
UCSCiuc002phu.3. human.

Organism-specific databases

CTDi56344.
GeneCardsiCABP5.
HGNCiHGNC:13714. CABP5.
HPAiHPA043698.
MIMi607315. gene.
neXtProtiNX_Q9NP86.
PharmGKBiPA26004.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0027. Eukaryota.
COG5126. LUCA.
GeneTreeiENSGT00760000118901.
HOGENOMiHOG000233018.
HOVERGENiHBG012180.
InParanoidiQ9NP86.
OMAiTEMELTE.
OrthoDBiEOG7XM303.
PhylomeDBiQ9NP86.
TreeFamiTF334804.

Miscellaneous databases

GenomeRNAii56344.
PROiQ9NP86.
SOURCEiSearch...

Gene expression databases

BgeeiQ9NP86.
CleanExiHS_CABP5.
GenevisibleiQ9NP86. HS.

Family and domain databases

Gene3Di1.10.238.10. 2 hits.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
[Graphical view]
PfamiPF13499. EF-hand_7. 2 hits.
[Graphical view]
SMARTiSM00054. EFh. 3 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS00018. EF_HAND_1. 3 hits.
PS50222. EF_HAND_2. 4 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Five members of a novel Ca(2+)-binding protein (CABP) subfamily with similarity to calmodulin."
    Haeseleer F., Sokal I., Verlinde C.L.M.J., Erdjument-Bromage H., Tempst P., Pronin A.N., Benovic J.L., Fariss R.N., Palczewski K.
    J. Biol. Chem. 275:1247-1260(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
    Tissue: Retina.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. "Ca(2+)-binding proteins in the retina: from discovery to etiology of human disease."
    Sokal I., Li N., Verlinde C.L.M.J., Haeseleer F., Baehr W., Palczewski K.
    Biochim. Biophys. Acta 1498:233-251(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  4. "Membrane targeting of the EF-hand containing calcium-sensing proteins CaBP7 and CaBP8."
    McCue H.V., Burgoyne R.D., Haynes L.P.
    Biochem. Biophys. Res. Commun. 380:825-831(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.

Entry informationi

Entry nameiCABP5_HUMAN
AccessioniPrimary (citable) accession number: Q9NP86
Secondary accession number(s): A0AUY4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: October 1, 2000
Last modified: June 8, 2016
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.