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Protein

Calcium-binding protein 5

Gene

CABP5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Inhibits calcium-dependent inactivation of L-type calcium channel and shifts voltage dependence of activation to more depolarized membrane potentials. Involved in the transmission of light signals (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi41 – 521PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi118 – 1292PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi155 – 1663PROSITE-ProRule annotationAdd BLAST12

GO - Molecular functioni

  • calcium ion binding Source: UniProtKB

GO - Biological processi

  • signal transduction Source: UniProtKB

Keywordsi

LigandCalcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Calcium-binding protein 5
Short name:
CaBP5
Gene namesi
Name:CABP5
Synonyms:CABP3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:13714. CABP5.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: MGI

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000105507.
PharmGKBiPA26004.

Polymorphism and mutation databases

BioMutaiCABP5.
DMDMi13431356.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000735241 – 173Calcium-binding protein 5Add BLAST173

Proteomic databases

PaxDbiQ9NP86.
PeptideAtlasiQ9NP86.
PRIDEiQ9NP86.

Expressioni

Tissue specificityi

Retina.1 Publication

Gene expression databases

BgeeiENSG00000105507.
CleanExiHS_CABP5.
GenevisibleiQ9NP86. HS.

Interactioni

Subunit structurei

Interacts with CACNA1C (via C-terminal CDB motif) in a calcium-dependent manner.By similarity

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi121142. 7 interactors.
IntActiQ9NP86. 19 interactors.
STRINGi9606.ENSP00000293255.

Structurei

3D structure databases

ProteinModelPortaliQ9NP86.
SMRiQ9NP86.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini28 – 63EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini64 – 99EF-hand 2PROSITE-ProRule annotationAdd BLAST36
Domaini105 – 140EF-hand 3PROSITE-ProRule annotationAdd BLAST36
Domaini142 – 173EF-hand 4PROSITE-ProRule annotationAdd BLAST32

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0027. Eukaryota.
COG5126. LUCA.
GeneTreeiENSGT00760000118901.
HOGENOMiHOG000233018.
HOVERGENiHBG012180.
InParanoidiQ9NP86.
OMAiAFNEFDK.
OrthoDBiEOG091G0PB4.
PhylomeDBiQ9NP86.
TreeFamiTF334804.

Family and domain databases

CDDicd00051. EFh. 2 hits.
InterProiView protein in InterPro
IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
PfamiView protein in Pfam
PF13499. EF-hand_7. 2 hits.
SMARTiView protein in SMART
SM00054. EFh. 3 hits.
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiView protein in PROSITE
PS00018. EF_HAND_1. 3 hits.
PS50222. EF_HAND_2. 4 hits.

Sequencei

Sequence statusi: Complete.

Q9NP86-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQFPMGPACI FLRKGIAEKQ RERPLGQDEI EELREAFLEF DKDRDGFISC
60 70 80 90 100
KDLGNLMRTM GYMPTEMELI ELGQQIRMNL GGRVDFDDFV ELMTPKLLAE
110 120 130 140 150
TAGMIGVQEM RDAFKEFDTN GDGEITLVEL QQAMQRLLGE RLTPREISEV
160 170
VREADVNGDG TVDFEEFVKM MSR
Length:173
Mass (Da):19,826
Last modified:October 1, 2000 - v1
Checksum:iBB4DD28E9ECC55AF
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03369565T → R. Corresponds to variant dbSNP:rs34862923Ensembl.1
Natural variantiVAR_04863380L → P. Corresponds to variant dbSNP:rs8105198Ensembl.1
Natural variantiVAR_020020128V → A. Corresponds to variant dbSNP:rs3745746Ensembl.1
Natural variantiVAR_048634140E → K. Corresponds to variant dbSNP:rs34681062Ensembl.1
Natural variantiVAR_048635147I → S. Corresponds to variant dbSNP:rs10425606Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF170815
, AF170812, AF170813, AF170814 Genomic DNA. Translation: AAF25798.1.
AF169159 mRNA. Translation: AAF25793.1.
BC126133 mRNA. Translation: AAI26134.1.
BC126135 mRNA. Translation: AAI26136.1.
CCDSiCCDS12709.1.
RefSeqiNP_062829.1. NM_019855.4.
UniGeneiHs.117694.

Genome annotation databases

EnsembliENST00000293255; ENSP00000293255; ENSG00000105507.
GeneIDi56344.
KEGGihsa:56344.
UCSCiuc002phu.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiCABP5_HUMAN
AccessioniPrimary (citable) accession number: Q9NP86
Secondary accession number(s): A0AUY4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: October 1, 2000
Last modified: June 7, 2017
This is version 130 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot