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Q9NP84

- TNR12_HUMAN

UniProt

Q9NP84 - TNR12_HUMAN

Protein

Tumor necrosis factor receptor superfamily member 12A

Gene

TNFRSF12A

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Receptor for TNFSF12/TWEAK. Weak inducer of apoptosis in some cell types. Promotes angiogenesis and the proliferation of endothelial cells. May modulate cellular adhesion to matrix proteins.1 Publication

    GO - Molecular functioni

    1. protein binding Source: IntAct

    GO - Biological processi

    1. angiogenesis Source: UniProtKB-KW
    2. apoptotic process Source: UniProtKB-KW
    3. positive regulation of apoptotic process Source: UniProt
    4. positive regulation of axon extension Source: Ensembl
    5. positive regulation of extrinsic apoptotic signaling pathway Source: UniProtKB
    6. regulation of wound healing Source: UniProt
    7. substrate-dependent cell migration, cell attachment to substrate Source: Ensembl

    Keywords - Molecular functioni

    Developmental protein, Receptor

    Keywords - Biological processi

    Angiogenesis, Apoptosis, Cell adhesion, Differentiation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tumor necrosis factor receptor superfamily member 12A
    Alternative name(s):
    Fibroblast growth factor-inducible immediate-early response protein 14
    Short name:
    FGF-inducible 14
    Tweak-receptor
    Short name:
    TweakR
    CD_antigen: CD266
    Gene namesi
    Name:TNFRSF12A
    Synonyms:FN14
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 16

    Organism-specific databases

    HGNCiHGNC:18152. TNFRSF12A.

    Subcellular locationi

    GO - Cellular componenti

    1. cell surface Source: Ensembl
    2. integral component of membrane Source: UniProtKB-KW
    3. plasma membrane Source: Ensembl
    4. ruffle Source: Ensembl

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134976874.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2727Sequence AnalysisAdd
    BLAST
    Chaini28 – 129102Tumor necrosis factor receptor superfamily member 12APRO_0000034611Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi36 ↔ 491 Publication
    Disulfide bondi52 ↔ 671 Publication
    Disulfide bondi55 ↔ 641 Publication

    Keywords - PTMi

    Disulfide bond

    Proteomic databases

    MaxQBiQ9NP84.
    PaxDbiQ9NP84.
    PeptideAtlasiQ9NP84.
    PRIDEiQ9NP84.

    PTM databases

    PhosphoSiteiQ9NP84.

    Expressioni

    Tissue specificityi

    Highly expressed in heart, placenta and kidney. Intermediate expression in lung, skeletal muscle and pancreas.

    Inductioni

    By FGF1 and phorbol ester.

    Gene expression databases

    ArrayExpressiQ9NP84.
    BgeeiQ9NP84.
    CleanExiHS_TNFRSF12A.
    GenevestigatoriQ9NP84.

    Organism-specific databases

    HPAiCAB015941.
    HPA007853.

    Interactioni

    Subunit structurei

    Associates with TRAF1 and TRAF2, and probably also with TRAF3.

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    BIRC2Q134902EBI-2851995,EBI-514538
    TNFSF12O435082EBI-2851995,EBI-6932080
    TRAF2Q129333EBI-2851995,EBI-355744

    Protein-protein interaction databases

    BioGridi119478. 6 interactions.
    IntActiQ9NP84. 4 interactions.
    MINTiMINT-8415044.
    STRINGi9606.ENSP00000326737.

    Structurei

    Secondary structure

    1
    129
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi30 – 334
    Beta strandi41 – 433
    Turni44 – 474
    Beta strandi48 – 503
    Helixi52 – 576
    Helixi62 – 654

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2EQPNMR-A28-70[»]
    2KMZNMR-A28-80[»]
    2RPJNMR-A28-70[»]
    ProteinModelPortaliQ9NP84.
    SMRiQ9NP84. Positions 28-80.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ9NP84.

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini28 – 8053ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini102 – 12928CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei81 – 10121HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati36 – 6732TNFR-Cys; atypicalAdd
    BLAST

    Sequence similaritiesi

    Contains 1 TNFR-Cys repeat.Curated

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG39144.
    HOGENOMiHOG000154660.
    HOVERGENiHBG031553.
    KOiK05149.
    OMAiSGLLVWR.
    PhylomeDBiQ9NP84.
    TreeFamiTF337901.

    Family and domain databases

    InterProiIPR022316. TNFR_12.
    [Graphical view]
    PfamiPF12191. stn_TNFRSF12A. 1 hit.
    [Graphical view]
    PRINTSiPR01962. TNFACTORR12.
    ProDomiPD336131. TNFR_12. 1 hit.
    [Graphical view] [Entries sharing at least one domain]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9NP84-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MARGSLRRLL RLLVLGLWLA LLRSVAGEQA PGTAPCSRGS SWSADLDKCM    50
    DCASCRARPH SDFCLGCAAA PPAPFRLLWP ILGGALSLTF VLGLLSGFLV 100
    WRRCRRREKF TTPIEETGGE GCPAVALIQ 129
    Length:129
    Mass (Da):13,911
    Last modified:October 1, 2000 - v1
    Checksum:iBF3FDFB9C1E1C448
    GO
    Isoform 2 (identifier: Q9NP84-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         33-67: Missing.

    Show »
    Length:94
    Mass (Da):10,191
    Checksum:iE3C52B1308DC768F
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei33 – 6735Missing in isoform 2. 1 PublicationVSP_006519Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF191148 mRNA. Translation: AAF69108.1.
    AB035480 mRNA. Translation: BAA94792.1.
    AB035481 mRNA. Translation: BAB17850.1.
    CH471112 Genomic DNA. Translation: EAW85429.1.
    CH471112 Genomic DNA. Translation: EAW85430.1.
    BC002718 mRNA. Translation: AAH02718.1.
    CCDSiCCDS10489.1. [Q9NP84-1]
    RefSeqiNP_057723.1. NM_016639.2. [Q9NP84-1]
    UniGeneiHs.355899.

    Genome annotation databases

    EnsembliENST00000326577; ENSP00000326737; ENSG00000006327. [Q9NP84-1]
    ENST00000341627; ENSP00000343894; ENSG00000006327. [Q9NP84-2]
    GeneIDi51330.
    KEGGihsa:51330.
    UCSCiuc002csv.4. human. [Q9NP84-1]
    uc002csw.4. human. [Q9NP84-2]

    Polymorphism databases

    DMDMi21263626.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF191148 mRNA. Translation: AAF69108.1 .
    AB035480 mRNA. Translation: BAA94792.1 .
    AB035481 mRNA. Translation: BAB17850.1 .
    CH471112 Genomic DNA. Translation: EAW85429.1 .
    CH471112 Genomic DNA. Translation: EAW85430.1 .
    BC002718 mRNA. Translation: AAH02718.1 .
    CCDSi CCDS10489.1. [Q9NP84-1 ]
    RefSeqi NP_057723.1. NM_016639.2. [Q9NP84-1 ]
    UniGenei Hs.355899.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2EQP NMR - A 28-70 [» ]
    2KMZ NMR - A 28-80 [» ]
    2RPJ NMR - A 28-70 [» ]
    ProteinModelPortali Q9NP84.
    SMRi Q9NP84. Positions 28-80.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 119478. 6 interactions.
    IntActi Q9NP84. 4 interactions.
    MINTi MINT-8415044.
    STRINGi 9606.ENSP00000326737.

    Chemistry

    GuidetoPHARMACOLOGYi 1884.

    PTM databases

    PhosphoSitei Q9NP84.

    Polymorphism databases

    DMDMi 21263626.

    Proteomic databases

    MaxQBi Q9NP84.
    PaxDbi Q9NP84.
    PeptideAtlasi Q9NP84.
    PRIDEi Q9NP84.

    Protocols and materials databases

    DNASUi 51330.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000326577 ; ENSP00000326737 ; ENSG00000006327 . [Q9NP84-1 ]
    ENST00000341627 ; ENSP00000343894 ; ENSG00000006327 . [Q9NP84-2 ]
    GeneIDi 51330.
    KEGGi hsa:51330.
    UCSCi uc002csv.4. human. [Q9NP84-1 ]
    uc002csw.4. human. [Q9NP84-2 ]

    Organism-specific databases

    CTDi 51330.
    GeneCardsi GC16P003141.
    HGNCi HGNC:18152. TNFRSF12A.
    HPAi CAB015941.
    HPA007853.
    MIMi 605914. gene.
    neXtProti NX_Q9NP84.
    PharmGKBi PA134976874.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG39144.
    HOGENOMi HOG000154660.
    HOVERGENi HBG031553.
    KOi K05149.
    OMAi SGLLVWR.
    PhylomeDBi Q9NP84.
    TreeFami TF337901.

    Miscellaneous databases

    ChiTaRSi TNFRSF12A. human.
    EvolutionaryTracei Q9NP84.
    GeneWikii TNFRSF12A.
    GenomeRNAii 51330.
    NextBioi 54743.
    PROi Q9NP84.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9NP84.
    Bgeei Q9NP84.
    CleanExi HS_TNFRSF12A.
    Genevestigatori Q9NP84.

    Family and domain databases

    InterProi IPR022316. TNFR_12.
    [Graphical view ]
    Pfami PF12191. stn_TNFRSF12A. 1 hit.
    [Graphical view ]
    PRINTSi PR01962. TNFACTORR12.
    ProDomi PD336131. TNFR_12. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    ProtoNeti Search...

    Publicationsi

    1. "The Fn14 immediate-early response gene is induced during liver regeneration and highly expressed in both human and murine hepatocellular carcinomas."
      Feng S.-L.Y., Guo Y., Factor V.M., Thorgeirsson S.S., Bell D.W., Testa J.R., Peifley K.A., Winkles J.A.
      Am. J. Pathol. 156:1253-1261(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Placenta.
    2. "Human homologue of Fn14."
      Tanaka S., Sugimachi K.
      Submitted (DEC-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Uterus.
    5. "A novel TNF receptor family member binds TWEAK and is implicated in angiogenesis."
      Wiley S.R., Cassiano L., Lofton T., Davis-Smith T., Winkles J.A., Lindner V., Liu H., Daniel T.O., Smith C.A., Fanslow W.C.
      Immunity 15:837-846(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    6. "Solution structure of the STN_TNFRSF12A_TNFR domain of tumor necrosis factor receptor superfamily member 12A precursor."
      RIKEN structural genomics initiative (RSGI)
      Submitted (APR-2008) to the PDB data bank
      Cited for: STRUCTURE BY NMR OF 26-70.
    7. "Solution structure of the cysteine-rich domain in Fn14, a member of the tumor necrosis factor receptor superfamily."
      He F., Dang W., Saito K., Watanabe S., Kobayashi N., Guntert P., Kigawa T., Tanaka A., Muto Y., Yokoyama S.
      Protein Sci. 18:650-656(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: STRUCTURE BY NMR OF 26-70, DISULFIDE BONDS.

    Entry informationi

    Entry nameiTNR12_HUMAN
    AccessioniPrimary (citable) accession number: Q9NP84
    Secondary accession number(s): D3DUA6, Q9HCS0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 27, 2002
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 116 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human cell differentiation molecules
      CD nomenclature of surface proteins of human leucocytes and list of entries
    2. Human chromosome 16
      Human chromosome 16: entries, gene names and cross-references to MIM
    3. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    4. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3