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Q9NP80

- PLPL8_HUMAN

UniProt

Q9NP80 - PLPL8_HUMAN

Protein

Calcium-independent phospholipase A2-gamma

Gene

PNPLA8

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 111 (01 Oct 2014)
      Sequence version 1 (01 Oct 2000)
      Previous versions | rss
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    Functioni

    Calcium-independent phospholipase A2, which catalyzes the hydrolysis of the sn-2 position of glycerophospholipids, PtdSer and to a lower extent PtdCho. Cleaves membrane phospholipids.2 Publications

    Catalytic activityi

    2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate.

    Enzyme regulationi

    Inhibited by E-6-bromomethylene-3-1-naphthalenyl-2H-tetrahydropyran-2-one (BEL).

    pH dependencei

    Optimum pH is 8.0.

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB
    2. calcium-independent phospholipase A2 activity Source: UniProtKB
    3. lysophospholipase activity Source: UniProtKB-EC

    GO - Biological processi

    1. arachidonic acid metabolic process Source: UniProtKB
    2. arachidonic acid secretion Source: UniProtKB
    3. cell death Source: UniProtKB
    4. fatty acid metabolic process Source: UniProtKB
    5. glycerophospholipid biosynthetic process Source: Reactome
    6. linoleic acid metabolic process Source: UniProtKB
    7. phosphatidylcholine acyl-chain remodeling Source: Reactome
    8. phosphatidylcholine catabolic process Source: UniProtKB
    9. phosphatidylethanolamine acyl-chain remodeling Source: Reactome
    10. phosphatidylethanolamine catabolic process Source: UniProtKB
    11. phospholipid metabolic process Source: Reactome
    12. prostaglandin biosynthetic process Source: UniProtKB
    13. small molecule metabolic process Source: Reactome

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Lipid degradation, Lipid metabolism

    Enzyme and pathway databases

    ReactomeiREACT_120829. Acyl chain remodelling of PC.
    REACT_121369. Acyl chain remodelling of PE.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Calcium-independent phospholipase A2-gamma (EC:3.1.1.5)
    Alternative name(s):
    Intracellular membrane-associated calcium-independent phospholipase A2 gamma
    Short name:
    iPLA2-gamma
    PNPLA-gamma
    Patatin-like phospholipase domain-containing protein 8
    iPLA2-2
    Gene namesi
    Name:PNPLA8
    Synonyms:IPLA22, IPLA2G
    ORF Names:BM-043
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 7

    Organism-specific databases

    HGNCiHGNC:28900. PNPLA8.

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: Reactome
    2. Golgi membrane Source: UniProtKB-SubCell
    3. integral component of membrane Source: UniProtKB-KW
    4. intracellular Source: UniProtKB
    5. membrane Source: UniProtKB
    6. perinuclear region of cytoplasm Source: UniProtKB-SubCell
    7. peroxisomal membrane Source: UniProtKB
    8. peroxisome Source: UniProtKB

    Keywords - Cellular componenti

    Cytoplasm, Endoplasmic reticulum, Golgi apparatus, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA145148236.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 782782Calcium-independent phospholipase A2-gammaPRO_0000303214Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi4 – 41N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi361 – 3611N-linked (GlcNAc...)Sequence Analysis
    Modified residuei736 – 7361N6-succinyllysineBy similarity

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    MaxQBiQ9NP80.
    PaxDbiQ9NP80.
    PRIDEiQ9NP80.

    PTM databases

    PhosphoSiteiQ9NP80.

    Expressioni

    Tissue specificityi

    Expressed in parenchymal tissues including heart, skeletal muscle, placenta, brain, liver and pancreas. Also expressed in bronchial epithelial cells and kidney. Highest expression is observed in skeletal muscle and heart.4 Publications

    Gene expression databases

    ArrayExpressiQ9NP80.
    BgeeiQ9NP80.
    CleanExiHS_PNPLA8.
    GenevestigatoriQ9NP80.

    Organism-specific databases

    HPAiHPA020083.

    Interactioni

    Protein-protein interaction databases

    BioGridi119111. 1 interaction.
    IntActiQ9NP80. 1 interaction.
    MINTiMINT-4725725.
    STRINGi9606.ENSP00000257694.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9NP80.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei475 – 49521HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini445 – 640196PatatinAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi481 – 4855GXSXG

    Sequence similaritiesi

    Contains 1 patatin domain.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG3621.
    HOVERGENiHBG102100.
    InParanoidiQ9NP80.
    KOiK16815.
    OMAiKYDSKSQ.
    PhylomeDBiQ9NP80.
    TreeFamiTF319230.

    Family and domain databases

    InterProiIPR016035. Acyl_Trfase/lysoPLipase.
    IPR002641. Patatin/PLipase_A2-rel.
    [Graphical view]
    PfamiPF01734. Patatin. 1 hit.
    [Graphical view]
    SUPFAMiSSF52151. SSF52151. 1 hit.

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9NP80-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSINLTVDIY IYLLSNARSV CGKQRSKQLY FLFSPKHYWR ISHISLQRGF    50
    HTNIIRCKWT KSEAHSCSKH CYSPSNHGLH IGILKLSTSA PKGLTKVNIC 100
    MSRIKSTLNS VSKAVFGNQN EMISRLAQFK PSSQILRKVS DSGWLKQKNI 150
    KQAIKSLKKY SDKSAEKSPF PEEKSHIIDK EEDIGKRSLF HYTSSITTKF 200
    GDSFYFLSNH INSYFKRKEK MSQQKENEHF RDKSELEDKK VEEGKLRSPD 250
    PGILAYKPGS ESVHTVDKPT SPSAIPDVLQ VSTKQSIANF LSRPTEGVQA 300
    LVGGYIGGLV PKLKYDSKSQ SEEQEEPAKT DQAVSKDRNA EEKKRLSLQR 350
    EKIIARVSID NRTRALVQAL RRTTDPKLCI TRVEELTFHL LEFPEGKGVA 400
    VKERIIPYLL RLRQIKDETL QAAVREILAL IGYVDPVKGR GIRILSIDGG 450
    GTRGVVALQT LRKLVELTQK PVHQLFDYIC GVSTGAILAF MLGLFHMPLD 500
    ECEELYRKLG SDVFSQNVIV GTVKMSWSHA FYDSQTWENI LKDRMGSALM 550
    IETARNPTCP KVAAVSTIVN RGITPKAFVF RNYGHFPGIN SHYLGGCQYK 600
    MWQAIRASSA APGYFAEYAL GNDLHQDGGL LLNNPSALAM HECKCLWPDV 650
    PLECIVSLGT GRYESDVRNT VTYTSLKTKL SNVINSATDT EEVHIMLDGL 700
    LPPDTYFRFN PVMCENIPLD ESRNEKLDQL QLEGLKYIER NEQKMKKVAK 750
    ILSQEKTTLQ KINDWIKLKT DMYEGLPFFS KL 782
    Length:782
    Mass (Da):88,477
    Last modified:October 1, 2000 - v1
    Checksum:iC66AD18A53AF649A
    GO
    Isoform 2 (identifier: Q9NP80-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         565-626: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:720
    Mass (Da):81,602
    Checksum:iC5FEF9D74A3E9954
    GO
    Isoform 3 (identifier: Q9NP80-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-100: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:682
    Mass (Da):77,031
    Checksum:iB42D353E75FE540D
    GO

    Sequence cautioni

    The sequence AAF67630.1 differs from that shown. Reason: Erroneous initiation.
    The sequence BAA92090.1 differs from that shown. Reason: Erroneous initiation.
    The sequence EAL24384.1 differs from that shown. Reason: Erroneous gene model prediction.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti570 – 5756NRGITP → IGGITH in AAF67630. 1 PublicationCurated
    Sequence conflicti570 – 5712NR → GI in BAA92090. (PubMed:14702039)Curated
    Sequence conflicti622 – 6221N → S in BAA92090. (PubMed:14702039)Curated
    Sequence conflicti623 – 6231D → G in BX647865. (PubMed:17974005)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 100100Missing in isoform 3. 1 PublicationVSP_045594Add
    BLAST
    Alternative sequencei565 – 62662Missing in isoform 2. 1 PublicationVSP_028005Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB041261 mRNA. Translation: BAA94997.1.
    AF263613 mRNA. Translation: AAF75269.1.
    AF263947 mRNA. Translation: AAF81246.1.
    AL834147 mRNA. Translation: CAD38859.1.
    BX647865 mRNA. No translation available.
    AC005058 Genomic DNA. Translation: AAD08847.1.
    CH236947 Genomic DNA. Translation: EAL24384.1. Sequence problems.
    CH236947 Genomic DNA. Translation: EAL24385.1.
    CH471070 Genomic DNA. Translation: EAW83433.1.
    BC032999 mRNA. Translation: AAH32999.1.
    AK002115 mRNA. Translation: BAA92090.1. Different initiation.
    AK024335 mRNA. Translation: BAB14890.1.
    AF217519 mRNA. Translation: AAF67630.1. Different initiation.
    CCDSiCCDS34733.1. [Q9NP80-1]
    CCDS59075.1. [Q9NP80-3]
    CCDS59508.1. [Q9NP80-2]
    PIRiJC7284.
    RefSeqiNP_001242936.1. NM_001256007.1. [Q9NP80-1]
    NP_001242937.1. NM_001256008.1. [Q9NP80-1]
    NP_001242938.1. NM_001256009.1. [Q9NP80-2]
    NP_001242939.1. NM_001256010.1. [Q9NP80-3]
    NP_001242940.1. NM_001256011.1. [Q9NP80-3]
    NP_056538.1. NM_015723.3. [Q9NP80-1]
    XP_005250453.1. XM_005250396.2. [Q9NP80-2]
    UniGeneiHs.617340.

    Genome annotation databases

    EnsembliENST00000257694; ENSP00000257694; ENSG00000135241. [Q9NP80-1]
    ENST00000422087; ENSP00000410804; ENSG00000135241. [Q9NP80-1]
    ENST00000426128; ENSP00000394988; ENSG00000135241. [Q9NP80-2]
    ENST00000436062; ENSP00000406779; ENSG00000135241. [Q9NP80-1]
    ENST00000453085; ENSP00000402274; ENSG00000135241.
    ENST00000453144; ENSP00000387789; ENSG00000135241. [Q9NP80-3]
    GeneIDi50640.
    KEGGihsa:50640.
    UCSCiuc003vff.2. human. [Q9NP80-1]
    uc031syz.1. human. [Q9NP80-2]

    Polymorphism databases

    DMDMi74734299.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB041261 mRNA. Translation: BAA94997.1 .
    AF263613 mRNA. Translation: AAF75269.1 .
    AF263947 mRNA. Translation: AAF81246.1 .
    AL834147 mRNA. Translation: CAD38859.1 .
    BX647865 mRNA. No translation available.
    AC005058 Genomic DNA. Translation: AAD08847.1 .
    CH236947 Genomic DNA. Translation: EAL24384.1 . Sequence problems.
    CH236947 Genomic DNA. Translation: EAL24385.1 .
    CH471070 Genomic DNA. Translation: EAW83433.1 .
    BC032999 mRNA. Translation: AAH32999.1 .
    AK002115 mRNA. Translation: BAA92090.1 . Different initiation.
    AK024335 mRNA. Translation: BAB14890.1 .
    AF217519 mRNA. Translation: AAF67630.1 . Different initiation.
    CCDSi CCDS34733.1. [Q9NP80-1 ]
    CCDS59075.1. [Q9NP80-3 ]
    CCDS59508.1. [Q9NP80-2 ]
    PIRi JC7284.
    RefSeqi NP_001242936.1. NM_001256007.1. [Q9NP80-1 ]
    NP_001242937.1. NM_001256008.1. [Q9NP80-1 ]
    NP_001242938.1. NM_001256009.1. [Q9NP80-2 ]
    NP_001242939.1. NM_001256010.1. [Q9NP80-3 ]
    NP_001242940.1. NM_001256011.1. [Q9NP80-3 ]
    NP_056538.1. NM_015723.3. [Q9NP80-1 ]
    XP_005250453.1. XM_005250396.2. [Q9NP80-2 ]
    UniGenei Hs.617340.

    3D structure databases

    ProteinModelPortali Q9NP80.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 119111. 1 interaction.
    IntActi Q9NP80. 1 interaction.
    MINTi MINT-4725725.
    STRINGi 9606.ENSP00000257694.

    Chemistry

    ChEMBLi CHEMBL2189126.

    PTM databases

    PhosphoSitei Q9NP80.

    Polymorphism databases

    DMDMi 74734299.

    Proteomic databases

    MaxQBi Q9NP80.
    PaxDbi Q9NP80.
    PRIDEi Q9NP80.

    Protocols and materials databases

    DNASUi 50640.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000257694 ; ENSP00000257694 ; ENSG00000135241 . [Q9NP80-1 ]
    ENST00000422087 ; ENSP00000410804 ; ENSG00000135241 . [Q9NP80-1 ]
    ENST00000426128 ; ENSP00000394988 ; ENSG00000135241 . [Q9NP80-2 ]
    ENST00000436062 ; ENSP00000406779 ; ENSG00000135241 . [Q9NP80-1 ]
    ENST00000453085 ; ENSP00000402274 ; ENSG00000135241 .
    ENST00000453144 ; ENSP00000387789 ; ENSG00000135241 . [Q9NP80-3 ]
    GeneIDi 50640.
    KEGGi hsa:50640.
    UCSCi uc003vff.2. human. [Q9NP80-1 ]
    uc031syz.1. human. [Q9NP80-2 ]

    Organism-specific databases

    CTDi 50640.
    GeneCardsi GC07M108110.
    HGNCi HGNC:28900. PNPLA8.
    HPAi HPA020083.
    MIMi 612123. gene.
    neXtProti NX_Q9NP80.
    PharmGKBi PA145148236.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG3621.
    HOVERGENi HBG102100.
    InParanoidi Q9NP80.
    KOi K16815.
    OMAi KYDSKSQ.
    PhylomeDBi Q9NP80.
    TreeFami TF319230.

    Enzyme and pathway databases

    Reactomei REACT_120829. Acyl chain remodelling of PC.
    REACT_121369. Acyl chain remodelling of PE.

    Miscellaneous databases

    ChiTaRSi PNPLA8. human.
    GeneWikii PNPLA8.
    GenomeRNAii 50640.
    NextBioi 53186.
    PROi Q9NP80.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9NP80.
    Bgeei Q9NP80.
    CleanExi HS_PNPLA8.
    Genevestigatori Q9NP80.

    Family and domain databases

    InterProi IPR016035. Acyl_Trfase/lysoPLipase.
    IPR002641. Patatin/PLipase_A2-rel.
    [Graphical view ]
    Pfami PF01734. Patatin. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52151. SSF52151. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "A novel intracellular membrane-bound calcium-independent phospholipase A(2)."
      Tanaka H., Takeya R., Sumimoto H.
      Biochem. Biophys. Res. Commun. 272:320-326(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
    2. "The genomic organization, complete mRNA sequence, cloning, and expression of a novel human intracellular membrane-associated calcium-independent phospholipase A(2)."
      Mancuso D.J., Jenkins C.M., Gross R.W.
      J. Biol. Chem. 275:9937-9945(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, TISSUE SPECIFICITY, SUBCELLULAR LOCATION, CHARACTERIZATION.
      Tissue: Heart.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
      Tissue: Adipocyte and Amygdala.
    4. "The DNA sequence of human chromosome 7."
      Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
      , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
      Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "Human chromosome 7: DNA sequence and biology."
      Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S.
      , Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.-C.
      Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Testis.
    8. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 16-739 (ISOFORM 1).
      Tissue: Placenta.
    9. "A novel gene expressed in human bone marrow."
      Zhao M., Gu J., Li N., Peng Y., Han Z., Chen Z.
      Submitted (DEC-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 570-782 (ISOFORM 1).
      Tissue: Bone marrow.
    10. Cited for: TISSUE SPECIFICITY.
    11. "Group VIB Ca2+-independent phospholipase A2gamma promotes cellular membrane hydrolysis and prostaglandin production in a manner distinct from other intracellular phospholipases A2."
      Murakami M., Masuda S., Ueda-Semmyo K., Yoda E., Kuwata H., Takanezawa Y., Aoki J., Arai H., Sumimoto H., Ishikawa Y., Ishii T., Nakatani Y., Kudo I.
      J. Biol. Chem. 280:14028-14041(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, CHARACTERIZATION, TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiPLPL8_HUMAN
    AccessioniPrimary (citable) accession number: Q9NP80
    Secondary accession number(s): A4D0S1
    , C9JZI4, O95035, Q8N3I3, Q9H7T5, Q9NR17, Q9NUN2, Q9NZ79
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 11, 2007
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 111 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 7
      Human chromosome 7: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3