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Q9NP80

- PLPL8_HUMAN

UniProt

Q9NP80 - PLPL8_HUMAN

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Protein
Calcium-independent phospholipase A2-gamma
Gene
PNPLA8, IPLA22, IPLA2G, BM-043
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Calcium-independent phospholipase A2, which catalyzes the hydrolysis of the sn-2 position of glycerophospholipids, PtdSer and to a lower extent PtdCho. Cleaves membrane phospholipids.2 Publications

Catalytic activityi

2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate.

Enzyme regulationi

Inhibited by E-6-bromomethylene-3-1-naphthalenyl-2H-tetrahydropyran-2-one (BEL).

pH dependencei

Optimum pH is 8.0.

GO - Molecular functioni

  1. ATP binding Source: UniProtKB
  2. calcium-independent phospholipase A2 activity Source: UniProtKB
  3. lysophospholipase activity Source: UniProtKB-EC
Complete GO annotation...

GO - Biological processi

  1. arachidonic acid metabolic process Source: UniProtKB
  2. arachidonic acid secretion Source: UniProtKB
  3. cell death Source: UniProtKB
  4. fatty acid metabolic process Source: UniProtKB
  5. glycerophospholipid biosynthetic process Source: Reactome
  6. linoleic acid metabolic process Source: UniProtKB
  7. phosphatidylcholine acyl-chain remodeling Source: Reactome
  8. phosphatidylcholine catabolic process Source: UniProtKB
  9. phosphatidylethanolamine acyl-chain remodeling Source: Reactome
  10. phosphatidylethanolamine catabolic process Source: UniProtKB
  11. phospholipid metabolic process Source: Reactome
  12. prostaglandin biosynthetic process Source: UniProtKB
  13. small molecule metabolic process Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Lipid degradation, Lipid metabolism

Enzyme and pathway databases

ReactomeiREACT_120829. Acyl chain remodelling of PC.
REACT_121369. Acyl chain remodelling of PE.

Names & Taxonomyi

Protein namesi
Recommended name:
Calcium-independent phospholipase A2-gamma (EC:3.1.1.5)
Alternative name(s):
Intracellular membrane-associated calcium-independent phospholipase A2 gamma
Short name:
iPLA2-gamma
PNPLA-gamma
Patatin-like phospholipase domain-containing protein 8
iPLA2-2
Gene namesi
Name:PNPLA8
Synonyms:IPLA22, IPLA2G
ORF Names:BM-043
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 7

Organism-specific databases

HGNCiHGNC:28900. PNPLA8.

Subcellular locationi

Endoplasmic reticulum membrane; Single-pass membrane protein By similarity. Golgi apparatus membrane; Single-pass membrane protein By similarity. Cytoplasmperinuclear region By similarity 1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei475 – 49521Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. Golgi membrane Source: UniProtKB-SubCell
  2. endoplasmic reticulum membrane Source: Reactome
  3. integral component of membrane Source: UniProtKB-KW
  4. intracellular Source: UniProtKB
  5. membrane Source: UniProtKB
  6. perinuclear region of cytoplasm Source: UniProtKB-SubCell
  7. peroxisomal membrane Source: UniProtKB
  8. peroxisome Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Endoplasmic reticulum, Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA145148236.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 782782Calcium-independent phospholipase A2-gamma
PRO_0000303214Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi4 – 41N-linked (GlcNAc...) Reviewed prediction
Glycosylationi361 – 3611N-linked (GlcNAc...) Reviewed prediction
Modified residuei736 – 7361N6-succinyllysine By similarity

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ9NP80.
PaxDbiQ9NP80.
PRIDEiQ9NP80.

PTM databases

PhosphoSiteiQ9NP80.

Expressioni

Tissue specificityi

Expressed in parenchymal tissues including heart, skeletal muscle, placenta, brain, liver and pancreas. Also expressed in bronchial epithelial cells and kidney. Highest expression is observed in skeletal muscle and heart.4 Publications

Gene expression databases

ArrayExpressiQ9NP80.
BgeeiQ9NP80.
CleanExiHS_PNPLA8.
GenevestigatoriQ9NP80.

Organism-specific databases

HPAiHPA020083.

Interactioni

Protein-protein interaction databases

BioGridi119111. 1 interaction.
IntActiQ9NP80. 1 interaction.
MINTiMINT-4725725.
STRINGi9606.ENSP00000257694.

Structurei

3D structure databases

ProteinModelPortaliQ9NP80.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini445 – 640196Patatin
Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi481 – 4855GXSXG

Sequence similaritiesi

Contains 1 patatin domain.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG3621.
HOVERGENiHBG102100.
InParanoidiQ9NP80.
KOiK16815.
OMAiKYDSKSQ.
PhylomeDBiQ9NP80.
TreeFamiTF319230.

Family and domain databases

InterProiIPR016035. Acyl_Trfase/lysoPLipase.
IPR002641. Patatin/PLipase_A2-rel.
[Graphical view]
PfamiPF01734. Patatin. 1 hit.
[Graphical view]
SUPFAMiSSF52151. SSF52151. 1 hit.

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9NP80-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MSINLTVDIY IYLLSNARSV CGKQRSKQLY FLFSPKHYWR ISHISLQRGF    50
HTNIIRCKWT KSEAHSCSKH CYSPSNHGLH IGILKLSTSA PKGLTKVNIC 100
MSRIKSTLNS VSKAVFGNQN EMISRLAQFK PSSQILRKVS DSGWLKQKNI 150
KQAIKSLKKY SDKSAEKSPF PEEKSHIIDK EEDIGKRSLF HYTSSITTKF 200
GDSFYFLSNH INSYFKRKEK MSQQKENEHF RDKSELEDKK VEEGKLRSPD 250
PGILAYKPGS ESVHTVDKPT SPSAIPDVLQ VSTKQSIANF LSRPTEGVQA 300
LVGGYIGGLV PKLKYDSKSQ SEEQEEPAKT DQAVSKDRNA EEKKRLSLQR 350
EKIIARVSID NRTRALVQAL RRTTDPKLCI TRVEELTFHL LEFPEGKGVA 400
VKERIIPYLL RLRQIKDETL QAAVREILAL IGYVDPVKGR GIRILSIDGG 450
GTRGVVALQT LRKLVELTQK PVHQLFDYIC GVSTGAILAF MLGLFHMPLD 500
ECEELYRKLG SDVFSQNVIV GTVKMSWSHA FYDSQTWENI LKDRMGSALM 550
IETARNPTCP KVAAVSTIVN RGITPKAFVF RNYGHFPGIN SHYLGGCQYK 600
MWQAIRASSA APGYFAEYAL GNDLHQDGGL LLNNPSALAM HECKCLWPDV 650
PLECIVSLGT GRYESDVRNT VTYTSLKTKL SNVINSATDT EEVHIMLDGL 700
LPPDTYFRFN PVMCENIPLD ESRNEKLDQL QLEGLKYIER NEQKMKKVAK 750
ILSQEKTTLQ KINDWIKLKT DMYEGLPFFS KL 782
Length:782
Mass (Da):88,477
Last modified:October 1, 2000 - v1
Checksum:iC66AD18A53AF649A
GO
Isoform 2 (identifier: Q9NP80-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     565-626: Missing.

Note: No experimental confirmation available.

Show »
Length:720
Mass (Da):81,602
Checksum:iC5FEF9D74A3E9954
GO
Isoform 3 (identifier: Q9NP80-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-100: Missing.

Note: No experimental confirmation available.

Show »
Length:682
Mass (Da):77,031
Checksum:iB42D353E75FE540D
GO

Sequence cautioni

The sequence AAF67630.1 differs from that shown. Reason: Erroneous initiation.
The sequence BAA92090.1 differs from that shown. Reason: Erroneous initiation.
The sequence EAL24384.1 differs from that shown. Reason: Erroneous gene model prediction.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 100100Missing in isoform 3.
VSP_045594Add
BLAST
Alternative sequencei565 – 62662Missing in isoform 2.
VSP_028005Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti570 – 5756NRGITP → IGGITH in AAF67630. 1 Publication
Sequence conflicti570 – 5712NR → GI in BAA92090. 1 Publication
Sequence conflicti622 – 6221N → S in BAA92090. 1 Publication
Sequence conflicti623 – 6231D → G in BX647865. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB041261 mRNA. Translation: BAA94997.1.
AF263613 mRNA. Translation: AAF75269.1.
AF263947 mRNA. Translation: AAF81246.1.
AL834147 mRNA. Translation: CAD38859.1.
BX647865 mRNA. No translation available.
AC005058 Genomic DNA. Translation: AAD08847.1.
CH236947 Genomic DNA. Translation: EAL24384.1. Sequence problems.
CH236947 Genomic DNA. Translation: EAL24385.1.
CH471070 Genomic DNA. Translation: EAW83433.1.
BC032999 mRNA. Translation: AAH32999.1.
AK002115 mRNA. Translation: BAA92090.1. Different initiation.
AK024335 mRNA. Translation: BAB14890.1.
AF217519 mRNA. Translation: AAF67630.1. Different initiation.
CCDSiCCDS34733.1. [Q9NP80-1]
CCDS59075.1. [Q9NP80-3]
CCDS59508.1. [Q9NP80-2]
PIRiJC7284.
RefSeqiNP_001242936.1. NM_001256007.1. [Q9NP80-1]
NP_001242937.1. NM_001256008.1. [Q9NP80-1]
NP_001242938.1. NM_001256009.1. [Q9NP80-2]
NP_001242939.1. NM_001256010.1. [Q9NP80-3]
NP_001242940.1. NM_001256011.1. [Q9NP80-3]
NP_056538.1. NM_015723.3. [Q9NP80-1]
XP_005250453.1. XM_005250396.2. [Q9NP80-2]
UniGeneiHs.617340.

Genome annotation databases

EnsembliENST00000257694; ENSP00000257694; ENSG00000135241. [Q9NP80-1]
ENST00000422087; ENSP00000410804; ENSG00000135241. [Q9NP80-1]
ENST00000426128; ENSP00000394988; ENSG00000135241. [Q9NP80-2]
ENST00000436062; ENSP00000406779; ENSG00000135241. [Q9NP80-1]
ENST00000453085; ENSP00000402274; ENSG00000135241.
ENST00000453144; ENSP00000387789; ENSG00000135241. [Q9NP80-3]
GeneIDi50640.
KEGGihsa:50640.
UCSCiuc003vff.2. human. [Q9NP80-1]
uc031syz.1. human. [Q9NP80-2]

Polymorphism databases

DMDMi74734299.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB041261 mRNA. Translation: BAA94997.1 .
AF263613 mRNA. Translation: AAF75269.1 .
AF263947 mRNA. Translation: AAF81246.1 .
AL834147 mRNA. Translation: CAD38859.1 .
BX647865 mRNA. No translation available.
AC005058 Genomic DNA. Translation: AAD08847.1 .
CH236947 Genomic DNA. Translation: EAL24384.1 . Sequence problems.
CH236947 Genomic DNA. Translation: EAL24385.1 .
CH471070 Genomic DNA. Translation: EAW83433.1 .
BC032999 mRNA. Translation: AAH32999.1 .
AK002115 mRNA. Translation: BAA92090.1 . Different initiation.
AK024335 mRNA. Translation: BAB14890.1 .
AF217519 mRNA. Translation: AAF67630.1 . Different initiation.
CCDSi CCDS34733.1. [Q9NP80-1 ]
CCDS59075.1. [Q9NP80-3 ]
CCDS59508.1. [Q9NP80-2 ]
PIRi JC7284.
RefSeqi NP_001242936.1. NM_001256007.1. [Q9NP80-1 ]
NP_001242937.1. NM_001256008.1. [Q9NP80-1 ]
NP_001242938.1. NM_001256009.1. [Q9NP80-2 ]
NP_001242939.1. NM_001256010.1. [Q9NP80-3 ]
NP_001242940.1. NM_001256011.1. [Q9NP80-3 ]
NP_056538.1. NM_015723.3. [Q9NP80-1 ]
XP_005250453.1. XM_005250396.2. [Q9NP80-2 ]
UniGenei Hs.617340.

3D structure databases

ProteinModelPortali Q9NP80.
ModBasei Search...

Protein-protein interaction databases

BioGridi 119111. 1 interaction.
IntActi Q9NP80. 1 interaction.
MINTi MINT-4725725.
STRINGi 9606.ENSP00000257694.

Chemistry

ChEMBLi CHEMBL2189126.

PTM databases

PhosphoSitei Q9NP80.

Polymorphism databases

DMDMi 74734299.

Proteomic databases

MaxQBi Q9NP80.
PaxDbi Q9NP80.
PRIDEi Q9NP80.

Protocols and materials databases

DNASUi 50640.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000257694 ; ENSP00000257694 ; ENSG00000135241 . [Q9NP80-1 ]
ENST00000422087 ; ENSP00000410804 ; ENSG00000135241 . [Q9NP80-1 ]
ENST00000426128 ; ENSP00000394988 ; ENSG00000135241 . [Q9NP80-2 ]
ENST00000436062 ; ENSP00000406779 ; ENSG00000135241 . [Q9NP80-1 ]
ENST00000453085 ; ENSP00000402274 ; ENSG00000135241 .
ENST00000453144 ; ENSP00000387789 ; ENSG00000135241 . [Q9NP80-3 ]
GeneIDi 50640.
KEGGi hsa:50640.
UCSCi uc003vff.2. human. [Q9NP80-1 ]
uc031syz.1. human. [Q9NP80-2 ]

Organism-specific databases

CTDi 50640.
GeneCardsi GC07M108110.
HGNCi HGNC:28900. PNPLA8.
HPAi HPA020083.
MIMi 612123. gene.
neXtProti NX_Q9NP80.
PharmGKBi PA145148236.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG3621.
HOVERGENi HBG102100.
InParanoidi Q9NP80.
KOi K16815.
OMAi KYDSKSQ.
PhylomeDBi Q9NP80.
TreeFami TF319230.

Enzyme and pathway databases

Reactomei REACT_120829. Acyl chain remodelling of PC.
REACT_121369. Acyl chain remodelling of PE.

Miscellaneous databases

ChiTaRSi PNPLA8. human.
GeneWikii PNPLA8.
GenomeRNAii 50640.
NextBioi 53186.
PROi Q9NP80.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9NP80.
Bgeei Q9NP80.
CleanExi HS_PNPLA8.
Genevestigatori Q9NP80.

Family and domain databases

InterProi IPR016035. Acyl_Trfase/lysoPLipase.
IPR002641. Patatin/PLipase_A2-rel.
[Graphical view ]
Pfami PF01734. Patatin. 1 hit.
[Graphical view ]
SUPFAMi SSF52151. SSF52151. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A novel intracellular membrane-bound calcium-independent phospholipase A(2)."
    Tanaka H., Takeya R., Sumimoto H.
    Biochem. Biophys. Res. Commun. 272:320-326(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
  2. "The genomic organization, complete mRNA sequence, cloning, and expression of a novel human intracellular membrane-associated calcium-independent phospholipase A(2)."
    Mancuso D.J., Jenkins C.M., Gross R.W.
    J. Biol. Chem. 275:9937-9945(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, TISSUE SPECIFICITY, SUBCELLULAR LOCATION, CHARACTERIZATION.
    Tissue: Heart.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
    Tissue: Adipocyte and Amygdala.
  4. "The DNA sequence of human chromosome 7."
    Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
    , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
    Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "Human chromosome 7: DNA sequence and biology."
    Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S.
    , Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.-C.
    Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Testis.
  8. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 16-739 (ISOFORM 1).
    Tissue: Placenta.
  9. "A novel gene expressed in human bone marrow."
    Zhao M., Gu J., Li N., Peng Y., Han Z., Chen Z.
    Submitted (DEC-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 570-782 (ISOFORM 1).
    Tissue: Bone marrow.
  10. Cited for: TISSUE SPECIFICITY.
  11. "Group VIB Ca2+-independent phospholipase A2gamma promotes cellular membrane hydrolysis and prostaglandin production in a manner distinct from other intracellular phospholipases A2."
    Murakami M., Masuda S., Ueda-Semmyo K., Yoda E., Kuwata H., Takanezawa Y., Aoki J., Arai H., Sumimoto H., Ishikawa Y., Ishii T., Nakatani Y., Kudo I.
    J. Biol. Chem. 280:14028-14041(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, CHARACTERIZATION, TISSUE SPECIFICITY.

Entry informationi

Entry nameiPLPL8_HUMAN
AccessioniPrimary (citable) accession number: Q9NP80
Secondary accession number(s): A4D0S1
, C9JZI4, O95035, Q8N3I3, Q9H7T5, Q9NR17, Q9NUN2, Q9NZ79
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: October 1, 2000
Last modified: September 3, 2014
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi