Q9NP80 (PLPL8_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Calcium-independent phospholipase A2-gamma
EC=3.1.1.5

Alternative name(s):
Intracellular membrane-associated calcium-independent phospholipase A2 gamma
Short name=iPLA2-gamma
PNPLA-gamma
Patatin-like phospholipase domain-containing protein 8
iPLA2-2

Gene names

Name:	PNPLA8
Synonyms:	IPLA22, IPLA2G
ORF Names:	BM-043

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	782 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Calcium-independent phospholipase A2, which catalyzes the hydrolysis of the sn-2 position of glycerophospholipids, PtdSer and to a lower extent PtdCho. Cleaves membrane phospholipids. Ref.2 Ref.11
Catalytic activity	2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate.
Enzyme regulation	Inhibited by E-6-bromomethylene-3-1-naphthalenyl-2H-tetrahydropyran-2-one (BEL).
Subcellular location	Endoplasmic reticulum membrane; Single-pass membrane protein By similarity. Golgi apparatus membrane; Single-pass membrane protein By similarity. Cytoplasm › perinuclear region By similarity Ref.2.
Tissue specificity	Expressed in parenchymal tissues including heart, skeletal muscle, placenta, brain, liver and pancreas. Also expressed in bronchial epithelial cells and kidney. Highest expression is observed in skeletal muscle and heart. Ref.1 Ref.2 Ref.10 Ref.11
Sequence similarities	Contains 1 patatin domain.
Biophysicochemical properties	pH dependence: Optimum pH is 8.0.
Sequence caution	The sequence AAF67630.1 differs from that shown. Reason: Erroneous initiation. The sequence BAA92090.1 differs from that shown. Reason: Erroneous initiation. The sequence EAL24384.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
Biological process	Lipid degradation Lipid metabolism
Cellular component	Cytoplasm Endoplasmic reticulum Golgi apparatus Membrane
Coding sequence diversity	Alternative splicing
Domain	Transmembrane Transmembrane helix
Molecular function	Hydrolase
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	arachidonic acid metabolic process Inferred from direct assay Ref.1Ref.11. Source: UniProtKB arachidonic acid secretion Inferred from direct assay Ref.1Ref.11. Source: UniProtKB cell death Inferred from direct assay Ref.11. Source: UniProtKB glycerophospholipid biosynthetic process Traceable author statement. Source: Reactome linoleic acid metabolic process Inferred from direct assay Ref.11. Source: UniProtKB phosphatidylcholine acyl-chain remodeling Traceable author statement. Source: Reactome phosphatidylcholine catabolic process Inferred from direct assay Ref.11. Source: UniProtKB phosphatidylethanolamine acyl-chain remodeling Traceable author statement. Source: Reactome phosphatidylethanolamine catabolic process Inferred from direct assay Ref.11. Source: UniProtKB prostaglandin biosynthetic process Inferred from direct assay Ref.11. Source: UniProtKB
Cellular_component	Golgi membrane Inferred from electronic annotation. Source: UniProtKB-SubCell endoplasmic reticulum membrane Traceable author statement. Source: Reactome integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW perinuclear region of cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell peroxisomal membrane Inferred from direct assay Ref.2. Source: UniProtKB
Molecular_function	ATP binding Non-traceable author statement Ref.2. Source: UniProtKB calcium-independent phospholipase A2 activity Inferred from direct assay Ref.2Ref.1Ref.11. Source: UniProtKB lysophospholipase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9NP80-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9NP80-2)

The sequence of this isoform differs from the canonical sequence as follows:
     565-626: Missing.

Note: No experimental confirmation available.

Isoform 3 (identifier: Q9NP80-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-100: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 782	782	Calcium-independent phospholipase A2-gamma		PRO_0000303214
Regions
	Transmembrane	475 – 495	21	Helical; Potential
	Domain	445 – 640	196	Patatin
	Motif	481 – 485	5	GXSXG
Amino acid modifications
	Glycosylation	4	1	N-linked (GlcNAc...) Potential
	Glycosylation	361	1	N-linked (GlcNAc...) Potential
Natural variations
	Alternative sequence	1 – 100	100	Missing in isoform 3.		VSP_045594
	Alternative sequence	565 – 626	62	Missing in isoform 2.		VSP_028005
Experimental info
	Sequence conflict	570 – 575	6	NRGITP → IGGITH in AAF67630. Ref.9
	Sequence conflict	570 – 571	2	NR → GI in BAA92090. Ref.8
	Sequence conflict	622	1	N → S in BAA92090. Ref.8
	Sequence conflict	623	1	D → G in BX647865. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified October 1, 2000. Version 1. Checksum: C66AD18A53AF649A	FASTA	782	88,477
	10 20 30 40 50 60 MSINLTVDIY IYLLSNARSV CGKQRSKQLY FLFSPKHYWR ISHISLQRGF HTNIIRCKWT 70 80 90 100 110 120 KSEAHSCSKH CYSPSNHGLH IGILKLSTSA PKGLTKVNIC MSRIKSTLNS VSKAVFGNQN 130 140 150 160 170 180 EMISRLAQFK PSSQILRKVS DSGWLKQKNI KQAIKSLKKY SDKSAEKSPF PEEKSHIIDK 190 200 210 220 230 240 EEDIGKRSLF HYTSSITTKF GDSFYFLSNH INSYFKRKEK MSQQKENEHF RDKSELEDKK 250 260 270 280 290 300 VEEGKLRSPD PGILAYKPGS ESVHTVDKPT SPSAIPDVLQ VSTKQSIANF LSRPTEGVQA 310 320 330 340 350 360 LVGGYIGGLV PKLKYDSKSQ SEEQEEPAKT DQAVSKDRNA EEKKRLSLQR EKIIARVSID 370 380 390 400 410 420 NRTRALVQAL RRTTDPKLCI TRVEELTFHL LEFPEGKGVA VKERIIPYLL RLRQIKDETL 430 440 450 460 470 480 QAAVREILAL IGYVDPVKGR GIRILSIDGG GTRGVVALQT LRKLVELTQK PVHQLFDYIC 490 500 510 520 530 540 GVSTGAILAF MLGLFHMPLD ECEELYRKLG SDVFSQNVIV GTVKMSWSHA FYDSQTWENI 550 560 570 580 590 600 LKDRMGSALM IETARNPTCP KVAAVSTIVN RGITPKAFVF RNYGHFPGIN SHYLGGCQYK 610 620 630 640 650 660 MWQAIRASSA APGYFAEYAL GNDLHQDGGL LLNNPSALAM HECKCLWPDV PLECIVSLGT 670 680 690 700 710 720 GRYESDVRNT VTYTSLKTKL SNVINSATDT EEVHIMLDGL LPPDTYFRFN PVMCENIPLD 730 740 750 760 770 780 ESRNEKLDQL QLEGLKYIER NEQKMKKVAK ILSQEKTTLQ KINDWIKLKT DMYEGLPFFS KL
	Isoform 2 [UniParc]. Checksum: C5FEF9D74A3E9954	FASTA	720	81,602
	10 20 30 40 50 60 MSINLTVDIY IYLLSNARSV CGKQRSKQLY FLFSPKHYWR ISHISLQRGF HTNIIRCKWT 70 80 90 100 110 120 KSEAHSCSKH CYSPSNHGLH IGILKLSTSA PKGLTKVNIC MSRIKSTLNS VSKAVFGNQN 130 140 150 160 170 180 EMISRLAQFK PSSQILRKVS DSGWLKQKNI KQAIKSLKKY SDKSAEKSPF PEEKSHIIDK 190 200 210 220 230 240 EEDIGKRSLF HYTSSITTKF GDSFYFLSNH INSYFKRKEK MSQQKENEHF RDKSELEDKK 250 260 270 280 290 300 VEEGKLRSPD PGILAYKPGS ESVHTVDKPT SPSAIPDVLQ VSTKQSIANF LSRPTEGVQA 310 320 330 340 350 360 LVGGYIGGLV PKLKYDSKSQ SEEQEEPAKT DQAVSKDRNA EEKKRLSLQR EKIIARVSID 370 380 390 400 410 420 NRTRALVQAL RRTTDPKLCI TRVEELTFHL LEFPEGKGVA VKERIIPYLL RLRQIKDETL 430 440 450 460 470 480 QAAVREILAL IGYVDPVKGR GIRILSIDGG GTRGVVALQT LRKLVELTQK PVHQLFDYIC 490 500 510 520 530 540 GVSTGAILAF MLGLFHMPLD ECEELYRKLG SDVFSQNVIV GTVKMSWSHA FYDSQTWENI 550 560 570 580 590 600 LKDRMGSALM IETARNPTCP KVAADGGLLL NNPSALAMHE CKCLWPDVPL ECIVSLGTGR 610 620 630 640 650 660 YESDVRNTVT YTSLKTKLSN VINSATDTEE VHIMLDGLLP PDTYFRFNPV MCENIPLDES 670 680 690 700 710 720 RNEKLDQLQL EGLKYIERNE QKMKKVAKIL SQEKTTLQKI NDWIKLKTDM YEGLPFFSKL
	Isoform 3 [UniParc]. Checksum: B42D353E75FE540D	FASTA	682	77,031
	10 20 30 40 50 60 MSRIKSTLNS VSKAVFGNQN EMISRLAQFK PSSQILRKVS DSGWLKQKNI KQAIKSLKKY 70 80 90 100 110 120 SDKSAEKSPF PEEKSHIIDK EEDIGKRSLF HYTSSITTKF GDSFYFLSNH INSYFKRKEK 130 140 150 160 170 180 MSQQKENEHF RDKSELEDKK VEEGKLRSPD PGILAYKPGS ESVHTVDKPT SPSAIPDVLQ 190 200 210 220 230 240 VSTKQSIANF LSRPTEGVQA LVGGYIGGLV PKLKYDSKSQ SEEQEEPAKT DQAVSKDRNA 250 260 270 280 290 300 EEKKRLSLQR EKIIARVSID NRTRALVQAL RRTTDPKLCI TRVEELTFHL LEFPEGKGVA 310 320 330 340 350 360 VKERIIPYLL RLRQIKDETL QAAVREILAL IGYVDPVKGR GIRILSIDGG GTRGVVALQT 370 380 390 400 410 420 LRKLVELTQK PVHQLFDYIC GVSTGAILAF MLGLFHMPLD ECEELYRKLG SDVFSQNVIV 430 440 450 460 470 480 GTVKMSWSHA FYDSQTWENI LKDRMGSALM IETARNPTCP KVAAVSTIVN RGITPKAFVF 490 500 510 520 530 540 RNYGHFPGIN SHYLGGCQYK MWQAIRASSA APGYFAEYAL GNDLHQDGGL LLNNPSALAM 550 560 570 580 590 600 HECKCLWPDV PLECIVSLGT GRYESDVRNT VTYTSLKTKL SNVINSATDT EEVHIMLDGL 610 620 630 640 650 660 LPPDTYFRFN PVMCENIPLD ESRNEKLDQL QLEGLKYIER NEQKMKKVAK ILSQEKTTLQ 670 680 KINDWIKLKT DMYEGLPFFS KL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A novel intracellular membrane-bound calcium-independent phospholipase A(2)." Tanaka H., Takeya R., Sumimoto H. Biochem. Biophys. Res. Commun. 272:320-326(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
[2]	"The genomic organization, complete mRNA sequence, cloning, and expression of a novel human intracellular membrane-associated calcium-independent phospholipase A(2)." Mancuso D.J., Jenkins C.M., Gross R.W. J. Biol. Chem. 275:9937-9945(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, TISSUE SPECIFICITY, SUBCELLULAR LOCATION, CHARACTERIZATION. Tissue: Heart.
[3]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3). Tissue: Adipocyte and Amygdala.
[4]	"The DNA sequence of human chromosome 7." Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L. , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K. Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"Human chromosome 7: DNA sequence and biology." Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S. , Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.-C. Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Testis.
[8]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 16-739 (ISOFORM 1). Tissue: Placenta.
[9]	"A novel gene expressed in human bone marrow." Zhao M., Gu J., Li N., Peng Y., Han Z., Chen Z. Submitted (DEC-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 570-782 (ISOFORM 1). Tissue: Bone marrow.
[10]	"Identification and distribution of endoplasmic reticulum iPLA2." Kinsey G.R., Cummings B.S., Beckett C.S., Saavedra G., Zhang W., McHowat J., Schnellmann R.G. Biochem. Biophys. Res. Commun. 327:287-293(2005) [PubMed] [Europe PMC] [Abstract] Cited for: TISSUE SPECIFICITY.
[11]	"Group VIB Ca2+-independent phospholipase A2gamma promotes cellular membrane hydrolysis and prostaglandin production in a manner distinct from other intracellular phospholipases A2." Murakami M., Masuda S., Ueda-Semmyo K., Yoda E., Kuwata H., Takanezawa Y., Aoki J., Arai H., Sumimoto H., Ishikawa Y., Ishii T., Nakatani Y., Kudo I. J. Biol. Chem. 280:14028-14041(2005) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, CHARACTERIZATION, TISSUE SPECIFICITY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB041261 mRNA. Translation: BAA94997.1. AF263613 mRNA. Translation: AAF75269.1. AF263947 mRNA. Translation: AAF81246.1. AL834147 mRNA. Translation: CAD38859.1. BX647865 mRNA. No translation available. AC005058 Genomic DNA. Translation: AAD08847.1. CH236947 Genomic DNA. Translation: EAL24384.1. Sequence problems. CH236947 Genomic DNA. Translation: EAL24385.1. CH471070 Genomic DNA. Translation: EAW83433.1. BC032999 mRNA. Translation: AAH32999.1. AK002115 mRNA. Translation: BAA92090.1. Different initiation. AK024335 mRNA. Translation: BAB14890.1. AF217519 mRNA. Translation: AAF67630.1. Different initiation.
IPI	IPI00181047. IPI00784076. IPI00925582.
PIR	JC7284.
RefSeq	NP_001242936.1. NM_001256007.1. NP_001242937.1. NM_001256008.1. NP_001242938.1. NM_001256009.1. NP_001242939.1. NM_001256010.1. NP_001242940.1. NM_001256011.1. NP_056538.1. NM_015723.3.
UniGene	Hs.617340. Hs.732217.
3D structure databases
ProteinModelPortal	Q9NP80.
ModBase	Search...
Protein-protein interaction databases
MINT	MINT-4725725.
STRING	9606.ENSP00000257694.
PTM databases
PhosphoSite	Q9NP80.
Polymorphism databases
DMDM	74734299.
Proteomic databases
PaxDb	Q9NP80.
PRIDE	Q9NP80.
Protocols and materials databases
DNASU	50640.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000257694; ENSP00000257694; ENSG00000135241. ENST00000422087; ENSP00000410804; ENSG00000135241. ENST00000436062; ENSP00000406779; ENSG00000135241. ENST00000453085; ENSP00000402274; ENSG00000135241. ENST00000453144; ENSP00000387789; ENSG00000135241.
GeneID	50640.
KEGG	hsa:50640.
UCSC	uc003vff.1. human.
Organism-specific databases
CTD	50640.
GeneCards	GC07M108110.
HGNC	HGNC:28900. PNPLA8.
HPA	HPA020083.
MIM	612123. gene.
neXtProt	NX_Q9NP80.
PharmGKB	PA145148236.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG3621.
HOVERGEN	HBG102100.
InParanoid	Q9NP80.
KO	K16815.
OMA	PSNHGLH.
PhylomeDB	Q9NP80.
Enzyme and pathway databases
Reactome	REACT_111217. Metabolism.
Gene expression databases
ArrayExpress	Q9NP80.
Bgee	Q9NP80.
CleanEx	HS_PNPLA8.
Genevestigator	Q9NP80.
Family and domain databases
InterPro	IPR016035. Acyl_Trfase/lysoPLipase. IPR002641. Patatin/PLipase_A2-rel. [Graphical view]
Pfam	PF01734. Patatin. 1 hit. [Graphical view]
SUPFAM	SSF52151. Acyl_Trfase/lysoPlipase. 1 hit.
ProtoNet	Search...
Other
ChiTaRS	PNPLA8. human.
GenomeRNAi	50640.
NextBio	53186.
SOURCE	Search...

Entry information

Entry name

PLPL8_HUMAN

Accession

Primary (citable) accession number: Q9NP80
Secondary accession number(s): A4D0S1 , C9JZI4, O95035, Q8N3I3, Q9H7T5, Q9NR17, Q9NUN2, Q9NZ79

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 11, 2007
Last sequence update:	October 1, 2000
Last modified:	May 1, 2013
This is version 97 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.