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Q9NP78

- ABCB9_HUMAN

UniProt

Q9NP78 - ABCB9_HUMAN

Protein

ATP-binding cassette sub-family B member 9

Gene

ABCB9

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 141 (01 Oct 2014)
      Sequence version 1 (01 Oct 2000)
      Previous versions | rss
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    Functioni

    ATP-dependent low-affinity peptide transporter which translocates a broad spectrum of peptides from the cytosol to the lysosomal lumen. Displays a broad peptide length specificity from 6-mer up to at least 59-mer peptides with an optimum of 23-mers. Favors positively charged, aromatic or hydrophobic residues in the N- and C-terminal positions whereas negatively charged residues as well as asparagine and methionine are not favored.3 Publications

    Kineticsi

    1. KM=6.8 µM for peptide RRYQNSTCL1 Publication

    pH dependencei

    Optimum pH is 7.0.1 Publication

    Temperature dependencei

    Optimum temperature is 37 degrees Celsius.1 Publication

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi539 – 5468ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB
    2. peptide-transporting ATPase activity Source: UniProtKB
    3. protein binding Source: UniProt
    4. protein homodimerization activity Source: UniProtKB
    5. substrate-specific transmembrane transporter activity Source: UniProtKB

    GO - Biological processi

    1. peptide transport Source: UniProtKB
    2. protein transport Source: UniProtKB-KW
    3. transmembrane transport Source: RefGenome

    Keywords - Biological processi

    Peptide transport, Protein transport, Transport

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BRENDAi3.6.3.43. 2681.

    Protein family/group databases

    TCDBi3.A.1.209.2. the atp-binding cassette (abc) superfamily.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    ATP-binding cassette sub-family B member 9
    Alternative name(s):
    ATP-binding cassette transporter 9
    Short name:
    ABC transporter 9 protein
    Short name:
    hABCB9
    TAP-like protein
    Short name:
    TAPL
    Gene namesi
    Name:ABCB9
    Synonyms:KIAA1520
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 12

    Organism-specific databases

    HGNCiHGNC:50. ABCB9.

    Subcellular locationi

    Lysosome membrane 8 Publications; Multi-pass membrane protein 8 PublicationsPROSITE-ProRule annotation
    Note: May be located in membrane rafts.

    GO - Cellular componenti

    1. integral component of endoplasmic reticulum membrane Source: UniProtKB
    2. integral component of membrane Source: UniProtKB
    3. lysosomal membrane Source: UniProtKB
    4. lysosome Source: UniProt

    Keywords - Cellular componenti

    Lysosome, Membrane

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi136 – 1372LL → AA: No effect on lysosomal localization. 1 Publication

    Organism-specific databases

    PharmGKBiPA24391.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 766766ATP-binding cassette sub-family B member 9PRO_0000000252Add
    BLAST

    Proteomic databases

    PaxDbiQ9NP78.
    PRIDEiQ9NP78.

    PTM databases

    PhosphoSiteiQ9NP78.

    Expressioni

    Tissue specificityi

    Highly expressed in testis, and at moderate levels in brain, spinal cord, and thyroid. Not expressed in monocytes but strongly expressed during differentiation of monocytes to dendritic cells and macrophages.2 Publications

    Inductioni

    Not induced by interferon-gamma.1 Publication

    Gene expression databases

    ArrayExpressiQ9NP78.
    BgeeiQ9NP78.
    CleanExiHS_ABCB9.
    GenevestigatoriQ9NP78.

    Organism-specific databases

    HPAiHPA035114.

    Interactioni

    Subunit structurei

    Homodimer.1 Publication

    Protein-protein interaction databases

    BioGridi117021. 1 interaction.
    STRINGi9606.ENSP00000280560.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9NP78.
    SMRiQ9NP78. Positions 175-739.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei7 – 2721HelicalPROSITE-ProRule annotationAdd
    BLAST
    Transmembranei47 – 6721HelicalPROSITE-ProRule annotationAdd
    BLAST
    Transmembranei84 – 10421HelicalPROSITE-ProRule annotationAdd
    BLAST
    Transmembranei116 – 13621HelicalPROSITE-ProRule annotationAdd
    BLAST
    Transmembranei185 – 20521HelicalPROSITE-ProRule annotationAdd
    BLAST
    Transmembranei225 – 24521HelicalPROSITE-ProRule annotationAdd
    BLAST
    Transmembranei319 – 33921HelicalPROSITE-ProRule annotationAdd
    BLAST
    Transmembranei416 – 43621HelicalPROSITE-ProRule annotationAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini188 – 471284ABC transmembrane type-1PROSITE-ProRule annotationAdd
    BLAST
    Domaini504 – 740237ABC transporterPROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi384 – 3896Poly-Glu

    Domaini

    The N-terminal region comprising the first four transmembrane domains is required for lysosomal localization but not for homodimerization or peptide transport.3 Publications

    Sequence similaritiesi

    Contains 1 ABC transmembrane type-1 domain.PROSITE-ProRule annotation
    Contains 1 ABC transporter domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1132.
    HOVERGENiHBG008358.
    InParanoidiQ9NP78.
    KOiK05656.
    OrthoDBiEOG7Z3F4H.
    PhylomeDBiQ9NP78.
    TreeFamiTF105197.

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    InterProiIPR003593. AAA+_ATPase.
    IPR011527. ABC1_TM_dom.
    IPR003439. ABC_transporter-like.
    IPR017871. ABC_transporter_CS.
    IPR001140. ABC_transptr_TM_dom.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF00664. ABC_membrane. 1 hit.
    PF00005. ABC_tran. 1 hit.
    [Graphical view]
    SMARTiSM00382. AAA. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    SSF90123. SSF90123. 1 hit.
    PROSITEiPS50929. ABC_TM1F. 1 hit.
    PS00211. ABC_TRANSPORTER_1. 1 hit.
    PS50893. ABC_TRANSPORTER_2. 1 hit.
    [Graphical view]

    Sequences (6)i

    Sequence statusi: Complete.

    This entry describes 6 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9NP78-1) [UniParc]FASTAAdd to Basket

    Also known as: 12A, c1-l

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MRLWKAVVVT LAFMSVDICV TTAIYVFSHL DRSLLEDIRH FNIFDSVLDL    50
    WAACLYRSCL LLGATIGVAK NSALGPRRLR ASWLVITLVC LFVGIYAMVK 100
    LLLFSEVRRP IRDPWFWALF VWTYISLGAS FLLWWLLSTV RPGTQALEPG 150
    AATEAEGFPG SGRPPPEQAS GATLQKLLSY TKPDVAFLVA ASFFLIVAAL 200
    GETFLPYYTG RAIDGIVIQK SMDQFSTAVV IVCLLAIGSS FAAGIRGGIF 250
    TLIFARLNIR LRNCLFRSLV SQETSFFDEN RTGDLISRLT SDTTMVSDLV 300
    SQNINVFLRN TVKVTGVVVF MFSLSWQLSL VTFMGFPIIM MVSNIYGKYY 350
    KRLSKEVQNA LARASNTAEE TISAMKTVRS FANEEEEAEV YLRKLQQVYK 400
    LNRKEAAAYM YYVWGSGLTL LVVQVSILYY GGHLVISGQM TSGNLIAFII 450
    YEFVLGDCME SVGSVYSGLM QGVGAAEKVF EFIDRQPTMV HDGSLAPDHL 500
    EGRVDFENVT FTYRTRPHTQ VLQNVSFSLS PGKVTALVGP SGSGKSSCVN 550
    ILENFYPLEG GRVLLDGKPI SAYDHKYLHR VISLVSQEPV LFARSITDNI 600
    SYGLPTVPFE MVVEAAQKAN AHGFIMELQD GYSTETGEKG AQLSGGQKQR 650
    VAMARALVRN PPVLILDEAT SALDAESEYL IQQAIHGNLQ KHTVLIIAHR 700
    LSTVEHAHLI VVLDKGRVVQ QGTHQQLLAQ GGLYAKLVQR QMLGLQPAAD 750
    FTAGHNEPVA NGSHKA 766
    Length:766
    Mass (Da):84,475
    Last modified:October 1, 2000 - v1
    Checksum:iC83FA62C929EC792
    GO
    Isoform 2 (identifier: Q9NP78-2) [UniParc]FASTAAdd to Basket

    Also known as: c1-s

    The sequence of this isoform differs from the canonical sequence as follows:
         418-460: Missing.

    Show »
    Length:723
    Mass (Da):79,771
    Checksum:i8FEB1D7C16C59FBC
    GO
    Isoform 3 (identifier: Q9NP78-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         582-596: ISLVSQEPVLFARSI → VCARAWATLLRPFCI
         597-766: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:596
    Mass (Da):66,238
    Checksum:i9A6E46B08EE34D37
    GO
    Isoform 4 (identifier: Q9NP78-5) [UniParc]FASTAAdd to Basket

    Also known as: 12B

    The sequence of this isoform differs from the canonical sequence as follows:
         681-683: IQQ → CAG
         684-766: Missing.

    Show »
    Length:683
    Mass (Da):75,402
    Checksum:i840FD3B6FBD9E86B
    GO
    Isoform 5 (identifier: Q9NP78-6) [UniParc]FASTAAdd to Basket

    Also known as: 12C

    The sequence of this isoform differs from the canonical sequence as follows:
         682-766: Missing.

    Show »
    Length:681
    Mass (Da):75,284
    Checksum:iED56FBD9E86BA3D8
    GO
    Isoform 6 (identifier: Q9NP78-7) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         461-523: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:703
    Mass (Da):77,470
    Checksum:iEC9F3DAE5C28F419
    GO

    Sequence cautioni

    The sequence BAA96044.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.
    The sequence BAD66830.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti121 – 1211V → M.1 Publication
    Corresponds to variant rs3803002 [ dbSNP | Ensembl ].
    VAR_013701

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei418 – 46043Missing in isoform 2. 1 PublicationVSP_000027Add
    BLAST
    Alternative sequencei461 – 52363Missing in isoform 6. CuratedVSP_044884Add
    BLAST
    Alternative sequencei582 – 59615ISLVS…FARSI → VCARAWATLLRPFCI in isoform 3. 1 PublicationVSP_000029Add
    BLAST
    Alternative sequencei597 – 766170Missing in isoform 3. 1 PublicationVSP_000030Add
    BLAST
    Alternative sequencei681 – 6833IQQ → CAG in isoform 4. 1 PublicationVSP_041884
    Alternative sequencei682 – 76685Missing in isoform 5. 1 PublicationVSP_041885Add
    BLAST
    Alternative sequencei684 – 76683Missing in isoform 4. 1 PublicationVSP_041886Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB045381 mRNA. Translation: BAA97989.2.
    AF216494 mRNA. Translation: AAF89993.1.
    AB112582 mRNA. Translation: BAC98409.1.
    AB112583 mRNA. Translation: BAC98410.1.
    AB177852 mRNA. Translation: BAD66830.1. Different initiation.
    AB040953 mRNA. Translation: BAA96044.2. Different initiation.
    AK304295 mRNA. Translation: BAG65152.1.
    AC026362 Genomic DNA. No translation available.
    AC027290 Genomic DNA. No translation available.
    BC017348 mRNA. Translation: AAH17348.1.
    CCDSiCCDS58286.1. [Q9NP78-7]
    CCDS58287.1. [Q9NP78-6]
    CCDS58288.1. [Q9NP78-5]
    CCDS9241.1. [Q9NP78-1]
    RefSeqiNP_001229942.1. NM_001243013.1. [Q9NP78-7]
    NP_001229943.1. NM_001243014.1. [Q9NP78-6]
    NP_062570.1. NM_019624.3. [Q9NP78-2]
    NP_062571.1. NM_019625.3. [Q9NP78-1]
    NP_982269.2. NM_203444.3. [Q9NP78-5]
    UniGeneiHs.511951.

    Genome annotation databases

    EnsembliENST00000280560; ENSP00000280560; ENSG00000150967. [Q9NP78-1]
    ENST00000344275; ENSP00000456813; ENSG00000150967. [Q9NP78-6]
    ENST00000346530; ENSP00000280559; ENSG00000150967. [Q9NP78-2]
    ENST00000392439; ENSP00000376234; ENSG00000150967. [Q9NP78-1]
    ENST00000442833; ENSP00000456375; ENSG00000150967. [Q9NP78-5]
    ENST00000540285; ENSP00000441734; ENSG00000150967. [Q9NP78-7]
    ENST00000542678; ENSP00000440288; ENSG00000150967. [Q9NP78-1]
    GeneIDi23457.
    KEGGihsa:23457.
    UCSCiuc001udm.4. human. [Q9NP78-1]
    uc001udo.4. human. [Q9NP78-2]
    uc001udr.3. human. [Q9NP78-3]
    uc010taj.2. human.
    uc021rfp.1. human. [Q9NP78-5]

    Polymorphism databases

    DMDMi22095458.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Web resourcesi

    ABCMdb

    Database for mutations in ABC proteins

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB045381 mRNA. Translation: BAA97989.2 .
    AF216494 mRNA. Translation: AAF89993.1 .
    AB112582 mRNA. Translation: BAC98409.1 .
    AB112583 mRNA. Translation: BAC98410.1 .
    AB177852 mRNA. Translation: BAD66830.1 . Different initiation.
    AB040953 mRNA. Translation: BAA96044.2 . Different initiation.
    AK304295 mRNA. Translation: BAG65152.1 .
    AC026362 Genomic DNA. No translation available.
    AC027290 Genomic DNA. No translation available.
    BC017348 mRNA. Translation: AAH17348.1 .
    CCDSi CCDS58286.1. [Q9NP78-7 ]
    CCDS58287.1. [Q9NP78-6 ]
    CCDS58288.1. [Q9NP78-5 ]
    CCDS9241.1. [Q9NP78-1 ]
    RefSeqi NP_001229942.1. NM_001243013.1. [Q9NP78-7 ]
    NP_001229943.1. NM_001243014.1. [Q9NP78-6 ]
    NP_062570.1. NM_019624.3. [Q9NP78-2 ]
    NP_062571.1. NM_019625.3. [Q9NP78-1 ]
    NP_982269.2. NM_203444.3. [Q9NP78-5 ]
    UniGenei Hs.511951.

    3D structure databases

    ProteinModelPortali Q9NP78.
    SMRi Q9NP78. Positions 175-739.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 117021. 1 interaction.
    STRINGi 9606.ENSP00000280560.

    Chemistry

    ChEMBLi CHEMBL1293189.

    Protein family/group databases

    TCDBi 3.A.1.209.2. the atp-binding cassette (abc) superfamily.

    PTM databases

    PhosphoSitei Q9NP78.

    Polymorphism databases

    DMDMi 22095458.

    Proteomic databases

    PaxDbi Q9NP78.
    PRIDEi Q9NP78.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000280560 ; ENSP00000280560 ; ENSG00000150967 . [Q9NP78-1 ]
    ENST00000344275 ; ENSP00000456813 ; ENSG00000150967 . [Q9NP78-6 ]
    ENST00000346530 ; ENSP00000280559 ; ENSG00000150967 . [Q9NP78-2 ]
    ENST00000392439 ; ENSP00000376234 ; ENSG00000150967 . [Q9NP78-1 ]
    ENST00000442833 ; ENSP00000456375 ; ENSG00000150967 . [Q9NP78-5 ]
    ENST00000540285 ; ENSP00000441734 ; ENSG00000150967 . [Q9NP78-7 ]
    ENST00000542678 ; ENSP00000440288 ; ENSG00000150967 . [Q9NP78-1 ]
    GeneIDi 23457.
    KEGGi hsa:23457.
    UCSCi uc001udm.4. human. [Q9NP78-1 ]
    uc001udo.4. human. [Q9NP78-2 ]
    uc001udr.3. human. [Q9NP78-3 ]
    uc010taj.2. human.
    uc021rfp.1. human. [Q9NP78-5 ]

    Organism-specific databases

    CTDi 23457.
    GeneCardsi GC12M123413.
    HGNCi HGNC:50. ABCB9.
    HPAi HPA035114.
    MIMi 605453. gene.
    neXtProti NX_Q9NP78.
    PharmGKBi PA24391.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG1132.
    HOVERGENi HBG008358.
    InParanoidi Q9NP78.
    KOi K05656.
    OrthoDBi EOG7Z3F4H.
    PhylomeDBi Q9NP78.
    TreeFami TF105197.

    Enzyme and pathway databases

    BRENDAi 3.6.3.43. 2681.

    Miscellaneous databases

    GeneWikii ABCB9.
    GenomeRNAii 23457.
    NextBioi 45751.
    PROi Q9NP78.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9NP78.
    Bgeei Q9NP78.
    CleanExi HS_ABCB9.
    Genevestigatori Q9NP78.

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    InterProi IPR003593. AAA+_ATPase.
    IPR011527. ABC1_TM_dom.
    IPR003439. ABC_transporter-like.
    IPR017871. ABC_transporter_CS.
    IPR001140. ABC_transptr_TM_dom.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF00664. ABC_membrane. 1 hit.
    PF00005. ABC_tran. 1 hit.
    [Graphical view ]
    SMARTi SM00382. AAA. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    SSF90123. SSF90123. 1 hit.
    PROSITEi PS50929. ABC_TM1F. 1 hit.
    PS00211. ABC_TRANSPORTER_1. 1 hit.
    PS50893. ABC_TRANSPORTER_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A half-type ABC transporter TAPL is highly conserved between rodent and man, and the human gene is not responsive to interferon-gamma in contrast to TAP1 and TAP2."
      Kobayashi A., Kasano M., Maeda T., Hori S., Motojima K., Suzuki M., Fujiwara T., Takahashi E., Yabe T., Tanaka K., Kasahara M., Yamaguchi Y., Maeda M.
      J. Biochem. 128:711-718(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), INDUCTION.
      Tissue: Embryonic kidney.
    2. "Characterization of ABCB9, an ATP binding cassette protein associated with lysosomes."
      Zhang F., Zhang W., Liu L., Fisher C.L., Hui D., Childs S., Dorovini-Zis K., Ling V.
      J. Biol. Chem. 275:23287-23294(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
      Tissue: Lymphoblast.
    3. "Gene organization of human transporter associated with antigen processing-like (TAPL, ABCB9): analysis of alternative splicing variants and promoter activity."
      Kobayashi A., Hori S., Suita N., Maeda M.
      Biochem. Biophys. Res. Commun. 309:815-822(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 4 AND 5).
      Tissue: Cervix carcinoma and Embryonic kidney.
    4. "Alternative splice variants encoding unstable protein domains exist in the human brain."
      Homma K., Kikuno R.F., Nagase T., Ohara O., Nishikawa K.
      J. Mol. Biol. 343:1207-1220(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Brain.
    5. "Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
      Nagase T., Kikuno R., Ishikawa K., Hirosawa M., Ohara O.
      DNA Res. 7:143-150(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Brain.
    6. Ohara O., Nagase T., Kikuno R.
      Submitted (JAN-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: SEQUENCE REVISION.
    7. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Trachea.
    8. "The finished DNA sequence of human chromosome 12."
      Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.
      , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A.
      Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    9. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
      Tissue: Brain.
    10. "Membrane localization of transporter associated with antigen processing (TAP)-like (ABCB9) visualized in vivo with a fluorescence protein-fusion technique."
      Kobayashi A., Maeda T., Maeda M.
      Biol. Pharm. Bull. 27:1916-1922(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION, DOMAIN.
    11. "Selective and ATP-dependent translocation of peptides by the homodimeric ATP binding cassette transporter TAP-like (ABCB9)."
      Wolters J.C., Abele R., Tampe R.
      J. Biol. Chem. 280:23631-23636(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, BIOPHYSICOCHEMICAL PROPERTIES, SUBUNIT.
    12. "Identification of a lysosomal peptide transport system induced during dendritic cell development."
      Demirel O., Waibler Z., Kalinke U., Grunebach F., Appel S., Brossart P., Hasilik A., Tampe R., Abele R.
      J. Biol. Chem. 282:37836-37843(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    13. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
      Tissue: Placenta.
    14. Cited for: SUBCELLULAR LOCATION.
    15. "Biochemical characterization of transporter associated with antigen processing (TAP)-like (ABCB9) expressed in insect cells."
      Ohara T., Ohashi-Kobayashi A., Maeda M.
      Biol. Pharm. Bull. 31:1-5(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION, DOMAIN.
    16. "Peptide specificity and lipid activation of the lysosomal transport complex ABCB9 (TAPL)."
      Zhao C., Haase W., Tampe R., Abele R.
      J. Biol. Chem. 283:17083-17091(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    17. "Tuning the cellular trafficking of the lysosomal peptide transporter TAPL by its N-terminal domain."
      Demirel O., Bangert I., Tampe R., Abele R.
      Traffic 11:383-393(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION, DOMAIN, MUTAGENESIS OF 136-LYS-LYS-137.
    18. "Transporter associated with antigen processing-like (ABCB9) stably expressed in Chinese hamster ovary-K1 cells is sorted to the microdomains of lysosomal membranes."
      Fujimoto Y., Kamakura A., Motohashi Y., Ohashi-Kobayashi A., Maeda M.
      Biol. Pharm. Bull. 34:36-40(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION.
    19. "Three hundred twenty-six genetic variations in genes encoding nine members of ATP-binding cassette, subfamily B (ABCB/MDR/TAP), in the Japanese population."
      Saito S., Iida A., Sekine A., Miura Y., Ogawa C., Kawauchi S., Higuchi S., Nakamura Y.
      J. Hum. Genet. 47:38-50(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANT MET-121.

    Entry informationi

    Entry nameiABCB9_HUMAN
    AccessioniPrimary (citable) accession number: Q9NP78
    Secondary accession number(s): B4E2J0
    , Q5W9G7, Q769F3, Q769F4, Q96AB1, Q9P208
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 2, 2002
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 141 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 12
      Human chromosome 12: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3