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Q9NP78 (ABCB9_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 136. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
ATP-binding cassette sub-family B member 9
Alternative name(s):
ATP-binding cassette transporter 9
Short name=ABC transporter 9 protein
Short name=hABCB9
TAP-like protein
Short name=TAPL
Gene names
Name:ABCB9
Synonyms:KIAA1520
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length766 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

ATP-dependent low-affinity peptide transporter which translocates a broad spectrum of peptides from the cytosol to the lysosomal lumen. Displays a broad peptide length specificity from 6-mer up to at least 59-mer peptides with an optimum of 23-mers. Favors positively charged, aromatic or hydrophobic residues in the N- and C-terminal positions whereas negatively charged residues as well as asparagine and methionine are not favored. Ref.11 Ref.12 Ref.16

Subunit structure

Homodimer. Ref.11

Subcellular location

Lysosome membrane; Multi-pass membrane protein. Note: May be located in membrane rafts. Ref.2 Ref.10 Ref.12 Ref.13 Ref.14 Ref.15 Ref.17 Ref.18

Tissue specificity

Highly expressed in testis, and at moderate levels in brain, spinal cord, and thyroid. Not expressed in monocytes but strongly expressed during differentiation of monocytes to dendritic cells and macrophages. Ref.2 Ref.12

Induction

Not induced by interferon-gamma. Ref.1

Domain

The N-terminal region comprising the first four transmembrane domains is required for lysosomal localization but not for homodimerization or peptide transport. Ref.10 Ref.15 Ref.17

Sequence similarities

Belongs to the ABC transporter superfamily. ABCB family. MHC peptide exporter (TC 3.A.1.209) subfamily. [View classification]

Contains 1 ABC transmembrane type-1 domain.

Contains 1 ABC transporter domain.

Caution

Has also been detected in the endoplasmic reticulum (Ref.1) but appears to be a lysosomal protein in vivo.

Biophysicochemical properties

Kinetic parameters:

KM=6.8 µM for peptide RRYQNSTCL Ref.11

pH dependence:

Optimum pH is 7.0.

Temperature dependence:

Optimum temperature is 37 degrees Celsius.

Sequence caution

The sequence BAA96044.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

The sequence BAD66830.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Ontologies

Keywords
   Biological processPeptide transport
Protein transport
Transport
   Cellular componentLysosome
Membrane
   Coding sequence diversityAlternative splicing
Polymorphism
   DomainTransmembrane
Transmembrane helix
   LigandATP-binding
Nucleotide-binding
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processoligopeptide transmembrane transport

Inferred from Biological aspect of Ancestor. Source: GOC

peptide transport

Inferred from direct assay Ref.12Ref.16. Source: UniProtKB

positive regulation of T cell mediated cytotoxicity

Inferred from Biological aspect of Ancestor. Source: RefGenome

protein transport

Inferred from electronic annotation. Source: UniProtKB-KW

transmembrane transport

Inferred from Biological aspect of Ancestor. Source: RefGenome

   Cellular_componentTAP complex

Inferred from Biological aspect of Ancestor. Source: RefGenome

integral component of endoplasmic reticulum membrane

Inferred from direct assay Ref.1Ref.10. Source: UniProtKB

integral component of membrane

Inferred from direct assay Ref.16. Source: UniProtKB

lysosomal membrane

Inferred from direct assay Ref.2Ref.13Ref.12Ref.14. Source: UniProtKB

lysosome

Inferred from direct assay PubMed 22641697. Source: UniProt

plasma membrane

Inferred from Biological aspect of Ancestor. Source: RefGenome

   Molecular_functionATP binding

Inferred from direct assay Ref.11. Source: UniProtKB

MHC class I protein binding

Inferred from Biological aspect of Ancestor. Source: RefGenome

TAP1 binding

Inferred from Biological aspect of Ancestor. Source: RefGenome

TAP2 binding

Inferred from Biological aspect of Ancestor. Source: RefGenome

oligopeptide-transporting ATPase activity

Inferred from Biological aspect of Ancestor. Source: RefGenome

peptide antigen binding

Inferred from Biological aspect of Ancestor. Source: RefGenome

peptide-transporting ATPase activity

Inferred from direct assay Ref.12Ref.16. Source: UniProtKB

protein homodimerization activity

Inferred from direct assay Ref.16. Source: UniProtKB

substrate-specific transmembrane transporter activity

Inferred from direct assay Ref.16. Source: UniProtKB

tapasin binding

Inferred from Biological aspect of Ancestor. Source: RefGenome

Complete GO annotation...

Alternative products

This entry describes 6 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q9NP78-1)

Also known as: 12A; c1-l;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q9NP78-2)

Also known as: c1-s;

The sequence of this isoform differs from the canonical sequence as follows:
     418-460: Missing.
Isoform 3 (identifier: Q9NP78-3)

The sequence of this isoform differs from the canonical sequence as follows:
     582-596: ISLVSQEPVLFARSI → VCARAWATLLRPFCI
     597-766: Missing.
Note: No experimental confirmation available.
Isoform 4 (identifier: Q9NP78-5)

Also known as: 12B;

The sequence of this isoform differs from the canonical sequence as follows:
     681-683: IQQ → CAG
     684-766: Missing.
Isoform 5 (identifier: Q9NP78-6)

Also known as: 12C;

The sequence of this isoform differs from the canonical sequence as follows:
     682-766: Missing.
Isoform 6 (identifier: Q9NP78-7)

The sequence of this isoform differs from the canonical sequence as follows:
     461-523: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 766766ATP-binding cassette sub-family B member 9
PRO_0000000252

Regions

Transmembrane7 – 2721Helical; Potential
Transmembrane47 – 6721Helical; Potential
Transmembrane84 – 10421Helical; Potential
Transmembrane116 – 13621Helical; Potential
Transmembrane185 – 20521Helical; Potential
Transmembrane225 – 24521Helical; Potential
Transmembrane319 – 33921Helical; Potential
Transmembrane416 – 43621Helical; Potential
Domain188 – 471284ABC transmembrane type-1
Domain504 – 740237ABC transporter
Nucleotide binding539 – 5468ATP Potential
Compositional bias384 – 3896Poly-Glu

Natural variations

Alternative sequence418 – 46043Missing in isoform 2.
VSP_000027
Alternative sequence461 – 52363Missing in isoform 6.
VSP_044884
Alternative sequence582 – 59615ISLVS…FARSI → VCARAWATLLRPFCI in isoform 3.
VSP_000029
Alternative sequence597 – 766170Missing in isoform 3.
VSP_000030
Alternative sequence681 – 6833IQQ → CAG in isoform 4.
VSP_041884
Alternative sequence682 – 76685Missing in isoform 5.
VSP_041885
Alternative sequence684 – 76683Missing in isoform 4.
VSP_041886
Natural variant1211V → M. Ref.19
Corresponds to variant rs3803002 [ dbSNP | Ensembl ].
VAR_013701

Experimental info

Mutagenesis136 – 1372LL → AA: No effect on lysosomal localization. Ref.17

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 (12A) (c1-l) [UniParc].

Last modified October 1, 2000. Version 1.
Checksum: C83FA62C929EC792

FASTA76684,475
        10         20         30         40         50         60 
MRLWKAVVVT LAFMSVDICV TTAIYVFSHL DRSLLEDIRH FNIFDSVLDL WAACLYRSCL 

        70         80         90        100        110        120 
LLGATIGVAK NSALGPRRLR ASWLVITLVC LFVGIYAMVK LLLFSEVRRP IRDPWFWALF 

       130        140        150        160        170        180 
VWTYISLGAS FLLWWLLSTV RPGTQALEPG AATEAEGFPG SGRPPPEQAS GATLQKLLSY 

       190        200        210        220        230        240 
TKPDVAFLVA ASFFLIVAAL GETFLPYYTG RAIDGIVIQK SMDQFSTAVV IVCLLAIGSS 

       250        260        270        280        290        300 
FAAGIRGGIF TLIFARLNIR LRNCLFRSLV SQETSFFDEN RTGDLISRLT SDTTMVSDLV 

       310        320        330        340        350        360 
SQNINVFLRN TVKVTGVVVF MFSLSWQLSL VTFMGFPIIM MVSNIYGKYY KRLSKEVQNA 

       370        380        390        400        410        420 
LARASNTAEE TISAMKTVRS FANEEEEAEV YLRKLQQVYK LNRKEAAAYM YYVWGSGLTL 

       430        440        450        460        470        480 
LVVQVSILYY GGHLVISGQM TSGNLIAFII YEFVLGDCME SVGSVYSGLM QGVGAAEKVF 

       490        500        510        520        530        540 
EFIDRQPTMV HDGSLAPDHL EGRVDFENVT FTYRTRPHTQ VLQNVSFSLS PGKVTALVGP 

       550        560        570        580        590        600 
SGSGKSSCVN ILENFYPLEG GRVLLDGKPI SAYDHKYLHR VISLVSQEPV LFARSITDNI 

       610        620        630        640        650        660 
SYGLPTVPFE MVVEAAQKAN AHGFIMELQD GYSTETGEKG AQLSGGQKQR VAMARALVRN 

       670        680        690        700        710        720 
PPVLILDEAT SALDAESEYL IQQAIHGNLQ KHTVLIIAHR LSTVEHAHLI VVLDKGRVVQ 

       730        740        750        760 
QGTHQQLLAQ GGLYAKLVQR QMLGLQPAAD FTAGHNEPVA NGSHKA 

« Hide

Isoform 2 (c1-s) [UniParc].

Checksum: 8FEB1D7C16C59FBC
Show »

FASTA72379,771
Isoform 3 [UniParc].

Checksum: 9A6E46B08EE34D37
Show »

FASTA59666,238
Isoform 4 (12B) [UniParc].

Checksum: 840FD3B6FBD9E86B
Show »

FASTA68375,402
Isoform 5 (12C) [UniParc].

Checksum: ED56FBD9E86BA3D8
Show »

FASTA68175,284
Isoform 6 [UniParc].

Checksum: EC9F3DAE5C28F419
Show »

FASTA70377,470

References

« Hide 'large scale' references
[1]"A half-type ABC transporter TAPL is highly conserved between rodent and man, and the human gene is not responsive to interferon-gamma in contrast to TAP1 and TAP2."
Kobayashi A., Kasano M., Maeda T., Hori S., Motojima K., Suzuki M., Fujiwara T., Takahashi E., Yabe T., Tanaka K., Kasahara M., Yamaguchi Y., Maeda M.
J. Biochem. 128:711-718(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), INDUCTION.
Tissue: Embryonic kidney.
[2]"Characterization of ABCB9, an ATP binding cassette protein associated with lysosomes."
Zhang F., Zhang W., Liu L., Fisher C.L., Hui D., Childs S., Dorovini-Zis K., Ling V.
J. Biol. Chem. 275:23287-23294(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
Tissue: Lymphoblast.
[3]"Gene organization of human transporter associated with antigen processing-like (TAPL, ABCB9): analysis of alternative splicing variants and promoter activity."
Kobayashi A., Hori S., Suita N., Maeda M.
Biochem. Biophys. Res. Commun. 309:815-822(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 4 AND 5).
Tissue: Cervix carcinoma and Embryonic kidney.
[4]"Alternative splice variants encoding unstable protein domains exist in the human brain."
Homma K., Kikuno R.F., Nagase T., Ohara O., Nishikawa K.
J. Mol. Biol. 343:1207-1220(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
Tissue: Brain.
[5]"Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
Nagase T., Kikuno R., Ishikawa K., Hirosawa M., Ohara O.
DNA Res. 7:143-150(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Brain.
[6]Ohara O., Nagase T., Kikuno R.
Submitted (JAN-2005) to the EMBL/GenBank/DDBJ databases
Cited for: SEQUENCE REVISION.
[7]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Trachea.
[8]"The finished DNA sequence of human chromosome 12."
Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R. expand/collapse author list , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A.
Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[9]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
Tissue: Brain.
[10]"Membrane localization of transporter associated with antigen processing (TAP)-like (ABCB9) visualized in vivo with a fluorescence protein-fusion technique."
Kobayashi A., Maeda T., Maeda M.
Biol. Pharm. Bull. 27:1916-1922(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION, DOMAIN.
[11]"Selective and ATP-dependent translocation of peptides by the homodimeric ATP binding cassette transporter TAP-like (ABCB9)."
Wolters J.C., Abele R., Tampe R.
J. Biol. Chem. 280:23631-23636(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, BIOPHYSICOCHEMICAL PROPERTIES, SUBUNIT.
[12]"Identification of a lysosomal peptide transport system induced during dendritic cell development."
Demirel O., Waibler Z., Kalinke U., Grunebach F., Appel S., Brossart P., Hasilik A., Tampe R., Abele R.
J. Biol. Chem. 282:37836-37843(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
[13]"Integral and associated lysosomal membrane proteins."
Schroeder B., Wrocklage C., Pan C., Jaeger R., Koesters B., Schaefer H., Elsaesser H.-P., Mann M., Hasilik A.
Traffic 8:1676-1686(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
Tissue: Placenta.
[14]"Functional dissection of transmembrane domains of human TAP-like (ABCB9)."
Kamakura A., Fujimoto Y., Motohashi Y., Ohashi K., Ohashi-Kobayashi A., Maeda M.
Biochem. Biophys. Res. Commun. 377:847-851(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION.
[15]"Biochemical characterization of transporter associated with antigen processing (TAP)-like (ABCB9) expressed in insect cells."
Ohara T., Ohashi-Kobayashi A., Maeda M.
Biol. Pharm. Bull. 31:1-5(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION, DOMAIN.
[16]"Peptide specificity and lipid activation of the lysosomal transport complex ABCB9 (TAPL)."
Zhao C., Haase W., Tampe R., Abele R.
J. Biol. Chem. 283:17083-17091(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[17]"Tuning the cellular trafficking of the lysosomal peptide transporter TAPL by its N-terminal domain."
Demirel O., Bangert I., Tampe R., Abele R.
Traffic 11:383-393(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION, DOMAIN, MUTAGENESIS OF 136-LYS-LYS-137.
[18]"Transporter associated with antigen processing-like (ABCB9) stably expressed in Chinese hamster ovary-K1 cells is sorted to the microdomains of lysosomal membranes."
Fujimoto Y., Kamakura A., Motohashi Y., Ohashi-Kobayashi A., Maeda M.
Biol. Pharm. Bull. 34:36-40(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION.
[19]"Three hundred twenty-six genetic variations in genes encoding nine members of ATP-binding cassette, subfamily B (ABCB/MDR/TAP), in the Japanese population."
Saito S., Iida A., Sekine A., Miura Y., Ogawa C., Kawauchi S., Higuchi S., Nakamura Y.
J. Hum. Genet. 47:38-50(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT MET-121.

Web resources

ABCMdb

Database for mutations in ABC proteins

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB045381 mRNA. Translation: BAA97989.2.
AF216494 mRNA. Translation: AAF89993.1.
AB112582 mRNA. Translation: BAC98409.1.
AB112583 mRNA. Translation: BAC98410.1.
AB177852 mRNA. Translation: BAD66830.1. Different initiation.
AB040953 mRNA. Translation: BAA96044.2. Different initiation.
AK304295 mRNA. Translation: BAG65152.1.
AC026362 Genomic DNA. No translation available.
AC027290 Genomic DNA. No translation available.
BC017348 mRNA. Translation: AAH17348.1.
RefSeqNP_001229942.1. NM_001243013.1.
NP_001229943.1. NM_001243014.1.
NP_062570.1. NM_019624.3.
NP_062571.1. NM_019625.3.
NP_982269.2. NM_203444.3.
UniGeneHs.511951.

3D structure databases

ProteinModelPortalQ9NP78.
SMRQ9NP78. Positions 175-741.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid117021. 1 interaction.
STRING9606.ENSP00000280560.

Chemistry

ChEMBLCHEMBL1293189.

Protein family/group databases

TCDB3.A.1.209.2. the atp-binding cassette (abc) superfamily.

PTM databases

PhosphoSiteQ9NP78.

Polymorphism databases

DMDM22095458.

Proteomic databases

PaxDbQ9NP78.
PRIDEQ9NP78.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000280560; ENSP00000280560; ENSG00000150967. [Q9NP78-1]
ENST00000344275; ENSP00000456813; ENSG00000150967. [Q9NP78-6]
ENST00000346530; ENSP00000280559; ENSG00000150967. [Q9NP78-2]
ENST00000392439; ENSP00000376234; ENSG00000150967. [Q9NP78-1]
ENST00000442833; ENSP00000456375; ENSG00000150967. [Q9NP78-5]
ENST00000540285; ENSP00000441734; ENSG00000150967. [Q9NP78-7]
ENST00000542678; ENSP00000440288; ENSG00000150967. [Q9NP78-1]
GeneID23457.
KEGGhsa:23457.
UCSCuc001udm.4. human. [Q9NP78-1]
uc001udo.4. human. [Q9NP78-2]
uc001udr.3. human. [Q9NP78-3]
uc010taj.2. human.
uc021rfp.1. human. [Q9NP78-5]

Organism-specific databases

CTD23457.
GeneCardsGC12M123413.
HGNCHGNC:50. ABCB9.
HPAHPA035114.
MIM605453. gene.
neXtProtNX_Q9NP78.
PharmGKBPA24391.
HUGESearch...
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG1132.
HOVERGENHBG008358.
InParanoidQ9NP78.
KOK05656.
OrthoDBEOG7Z3F4H.
PhylomeDBQ9NP78.
TreeFamTF105197.

Enzyme and pathway databases

BRENDA3.6.3.43. 2681.

Gene expression databases

ArrayExpressQ9NP78.
BgeeQ9NP78.
CleanExHS_ABCB9.
GenevestigatorQ9NP78.

Family and domain databases

Gene3D3.40.50.300. 1 hit.
InterProIPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR001140. ABC_transptr_TM_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamPF00664. ABC_membrane. 1 hit.
PF00005. ABC_tran. 1 hit.
[Graphical view]
SMARTSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
SSF90123. SSF90123. 1 hit.
PROSITEPS50929. ABC_TM1F. 1 hit.
PS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiABCB9.
GenomeRNAi23457.
NextBio45751.
PROQ9NP78.
SOURCESearch...

Entry information

Entry nameABCB9_HUMAN
AccessionPrimary (citable) accession number: Q9NP78
Secondary accession number(s): B4E2J0 expand/collapse secondary AC list , Q5W9G7, Q769F3, Q769F4, Q96AB1, Q9P208
Entry history
Integrated into UniProtKB/Swiss-Prot: August 2, 2002
Last sequence update: October 1, 2000
Last modified: April 16, 2014
This is version 136 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 12

Human chromosome 12: entries, gene names and cross-references to MIM