Q9NP78 (ABCB9_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
ATP-binding cassette sub-family B member 9

Alternative name(s):
ATP-binding cassette transporter 9
Short name=ABC transporter 9 protein
Short name=hABCB9
TAP-like protein
Short name=TAPL

Gene names

Name:	ABCB9
Synonyms:	KIAA1520

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	766 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	ATP-dependent low-affinity peptide transporter which translocates a broad spectrum of peptides from the cytosol to the lysosomal lumen. Displays a broad peptide length specificity from 6-mer up to at least 59-mer peptides with an optimum of 23-mers. Favors positively charged, aromatic or hydrophobic residues in the N- and C-terminal positions whereas negatively charged residues as well as asparagine and methionine are not favored. Ref.11 Ref.12 Ref.16
Subunit structure	Homodimer. Ref.11
Subcellular location	Lysosome membrane; Multi-pass membrane protein. Note: May be located in membrane rafts. Ref.2 Ref.10 Ref.12 Ref.13 Ref.14 Ref.15 Ref.17 Ref.18
Tissue specificity	Highly expressed in testis, and at moderate levels in brain, spinal cord, and thyroid. Not expressed in monocytes but strongly expressed during differentiation of monocytes to dendritic cells and macrophages. Ref.2 Ref.12
Induction	Not induced by interferon-gamma. Ref.1
Domain	The N-terminal region comprising the first four transmembrane domains is required for lysosomal localization but not for homodimerization or peptide transport. Ref.10 Ref.15 Ref.17
Sequence similarities	Belongs to the ABC transporter superfamily. ABCB family. MHC peptide exporter (TC 3.A.1.209) subfamily. [View classification] Contains 1 ABC transmembrane type-1 domain. Contains 1 ABC transporter domain.
Caution	Has also been detected in the endoplasmic reticulum (Ref.1) but appears to be a lysosomal protein in vivo.
Biophysicochemical properties	Kinetic parameters: KM=6.8 µM for peptide RRYQNSTCL Ref.11 pH dependence: Optimum pH is 7.0. Temperature dependence: Optimum temperature is 37 degrees Celsius.
Sequence caution	The sequence BAA96044.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened. The sequence BAD66830.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Ontologies

Keywords
Biological process	Peptide transport Protein transport Transport
Cellular component	Lysosome Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Transmembrane Transmembrane helix
Ligand	ATP-binding Nucleotide-binding
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	positive regulation of T cell mediated cytotoxicity Inferred from Biological aspect of Ancestor. Source: RefGenome protein transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	TAP complex Inferred from Biological aspect of Ancestor. Source: RefGenome lysosomal membrane Inferred from direct assay Ref.2Ref.12Ref.14. Source: UniProtKB plasma membrane Inferred from Biological aspect of Ancestor. Source: RefGenome
Molecular_function	ATP binding Inferred from direct assay Ref.11. Source: UniProtKB MHC class I protein binding Inferred from Biological aspect of Ancestor. Source: RefGenome TAP1 binding Inferred from Biological aspect of Ancestor. Source: RefGenome TAP2 binding Inferred from Biological aspect of Ancestor. Source: RefGenome oligopeptide-transporting ATPase activity Inferred from Biological aspect of Ancestor. Source: RefGenome peptide antigen binding Inferred from Biological aspect of Ancestor. Source: RefGenome protein homodimerization activity Inferred from direct assay Ref.16. Source: UniProtKB tapasin binding Inferred from Biological aspect of Ancestor. Source: RefGenome
Complete GO annotation...

Alternative products

This entry describes 6 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9NP78-1)

Also known as: 12A; c1-l;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9NP78-2)

Also known as: c1-s;

The sequence of this isoform differs from the canonical sequence as follows:
     418-460: Missing.

Isoform 3 (identifier: Q9NP78-3)

The sequence of this isoform differs from the canonical sequence as follows:
     582-596: ISLVSQEPVLFARSI → VCARAWATLLRPFCI
     597-766: Missing.

Note: No experimental confirmation available.

Isoform 4 (identifier: Q9NP78-5)

Also known as: 12B;

The sequence of this isoform differs from the canonical sequence as follows:
     681-683: IQQ → CAG
     684-766: Missing.

Isoform 5 (identifier: Q9NP78-6)

Also known as: 12C;

The sequence of this isoform differs from the canonical sequence as follows:
     682-766: Missing.

Isoform 6 (identifier: Q9NP78-7)

The sequence of this isoform differs from the canonical sequence as follows:
     461-523: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 766	766	ATP-binding cassette sub-family B member 9		PRO_0000000252
Regions
	Transmembrane	7 – 27	21	Helical; Potential
	Transmembrane	47 – 67	21	Helical; Potential
	Transmembrane	84 – 104	21	Helical; Potential
	Transmembrane	116 – 136	21	Helical; Potential
	Transmembrane	185 – 205	21	Helical; Potential
	Transmembrane	225 – 245	21	Helical; Potential
	Transmembrane	319 – 339	21	Helical; Potential
	Transmembrane	416 – 436	21	Helical; Potential
	Domain	188 – 471	284	ABC transmembrane type-1
	Domain	504 – 740	237	ABC transporter
	Nucleotide binding	539 – 546	8	ATP Potential
	Compositional bias	384 – 389	6	Poly-Glu
Natural variations
	Alternative sequence	418 – 460	43	Missing in isoform 2.		VSP_000027
	Alternative sequence	461 – 523	63	Missing in isoform 6.		VSP_044884
	Alternative sequence	582 – 596	15	ISLVS…FARSI → VCARAWATLLRPFCI in isoform 3.		VSP_000029
	Alternative sequence	597 – 766	170	Missing in isoform 3.		VSP_000030
	Alternative sequence	681 – 683	3	IQQ → CAG in isoform 4.		VSP_041884
	Alternative sequence	682 – 766	85	Missing in isoform 5.		VSP_041885
	Alternative sequence	684 – 766	83	Missing in isoform 4.		VSP_041886
	Natural variant	121	1	V → M. Ref.19 Corresponds to variant rs3803002 [ dbSNP | Ensembl ].		VAR_013701
Experimental info
	Mutagenesis	136 – 137	2	LL → AA: No effect on lysosomal localization. Ref.17

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 (12A) (c1-l) [UniParc]. Last modified October 1, 2000. Version 1. Checksum: C83FA62C929EC792	FASTA	766	84,475
	10 20 30 40 50 60 MRLWKAVVVT LAFMSVDICV TTAIYVFSHL DRSLLEDIRH FNIFDSVLDL WAACLYRSCL 70 80 90 100 110 120 LLGATIGVAK NSALGPRRLR ASWLVITLVC LFVGIYAMVK LLLFSEVRRP IRDPWFWALF 130 140 150 160 170 180 VWTYISLGAS FLLWWLLSTV RPGTQALEPG AATEAEGFPG SGRPPPEQAS GATLQKLLSY 190 200 210 220 230 240 TKPDVAFLVA ASFFLIVAAL GETFLPYYTG RAIDGIVIQK SMDQFSTAVV IVCLLAIGSS 250 260 270 280 290 300 FAAGIRGGIF TLIFARLNIR LRNCLFRSLV SQETSFFDEN RTGDLISRLT SDTTMVSDLV 310 320 330 340 350 360 SQNINVFLRN TVKVTGVVVF MFSLSWQLSL VTFMGFPIIM MVSNIYGKYY KRLSKEVQNA 370 380 390 400 410 420 LARASNTAEE TISAMKTVRS FANEEEEAEV YLRKLQQVYK LNRKEAAAYM YYVWGSGLTL 430 440 450 460 470 480 LVVQVSILYY GGHLVISGQM TSGNLIAFII YEFVLGDCME SVGSVYSGLM QGVGAAEKVF 490 500 510 520 530 540 EFIDRQPTMV HDGSLAPDHL EGRVDFENVT FTYRTRPHTQ VLQNVSFSLS PGKVTALVGP 550 560 570 580 590 600 SGSGKSSCVN ILENFYPLEG GRVLLDGKPI SAYDHKYLHR VISLVSQEPV LFARSITDNI 610 620 630 640 650 660 SYGLPTVPFE MVVEAAQKAN AHGFIMELQD GYSTETGEKG AQLSGGQKQR VAMARALVRN 670 680 690 700 710 720 PPVLILDEAT SALDAESEYL IQQAIHGNLQ KHTVLIIAHR LSTVEHAHLI VVLDKGRVVQ 730 740 750 760 QGTHQQLLAQ GGLYAKLVQR QMLGLQPAAD FTAGHNEPVA NGSHKA
	Isoform 2 (c1-s) [UniParc]. Checksum: 8FEB1D7C16C59FBC	FASTA	723	79,771
	10 20 30 40 50 60 MRLWKAVVVT LAFMSVDICV TTAIYVFSHL DRSLLEDIRH FNIFDSVLDL WAACLYRSCL 70 80 90 100 110 120 LLGATIGVAK NSALGPRRLR ASWLVITLVC LFVGIYAMVK LLLFSEVRRP IRDPWFWALF 130 140 150 160 170 180 VWTYISLGAS FLLWWLLSTV RPGTQALEPG AATEAEGFPG SGRPPPEQAS GATLQKLLSY 190 200 210 220 230 240 TKPDVAFLVA ASFFLIVAAL GETFLPYYTG RAIDGIVIQK SMDQFSTAVV IVCLLAIGSS 250 260 270 280 290 300 FAAGIRGGIF TLIFARLNIR LRNCLFRSLV SQETSFFDEN RTGDLISRLT SDTTMVSDLV 310 320 330 340 350 360 SQNINVFLRN TVKVTGVVVF MFSLSWQLSL VTFMGFPIIM MVSNIYGKYY KRLSKEVQNA 370 380 390 400 410 420 LARASNTAEE TISAMKTVRS FANEEEEAEV YLRKLQQVYK LNRKEAAAYM YYVWGSGSVG 430 440 450 460 470 480 SVYSGLMQGV GAAEKVFEFI DRQPTMVHDG SLAPDHLEGR VDFENVTFTY RTRPHTQVLQ 490 500 510 520 530 540 NVSFSLSPGK VTALVGPSGS GKSSCVNILE NFYPLEGGRV LLDGKPISAY DHKYLHRVIS 550 560 570 580 590 600 LVSQEPVLFA RSITDNISYG LPTVPFEMVV EAAQKANAHG FIMELQDGYS TETGEKGAQL 610 620 630 640 650 660 SGGQKQRVAM ARALVRNPPV LILDEATSAL DAESEYLIQQ AIHGNLQKHT VLIIAHRLST 670 680 690 700 710 720 VEHAHLIVVL DKGRVVQQGT HQQLLAQGGL YAKLVQRQML GLQPAADFTA GHNEPVANGS HKA
	Isoform 3 [UniParc]. Checksum: 9A6E46B08EE34D37	FASTA	596	66,238
	10 20 30 40 50 60 MRLWKAVVVT LAFMSVDICV TTAIYVFSHL DRSLLEDIRH FNIFDSVLDL WAACLYRSCL 70 80 90 100 110 120 LLGATIGVAK NSALGPRRLR ASWLVITLVC LFVGIYAMVK LLLFSEVRRP IRDPWFWALF 130 140 150 160 170 180 VWTYISLGAS FLLWWLLSTV RPGTQALEPG AATEAEGFPG SGRPPPEQAS GATLQKLLSY 190 200 210 220 230 240 TKPDVAFLVA ASFFLIVAAL GETFLPYYTG RAIDGIVIQK SMDQFSTAVV IVCLLAIGSS 250 260 270 280 290 300 FAAGIRGGIF TLIFARLNIR LRNCLFRSLV SQETSFFDEN RTGDLISRLT SDTTMVSDLV 310 320 330 340 350 360 SQNINVFLRN TVKVTGVVVF MFSLSWQLSL VTFMGFPIIM MVSNIYGKYY KRLSKEVQNA 370 380 390 400 410 420 LARASNTAEE TISAMKTVRS FANEEEEAEV YLRKLQQVYK LNRKEAAAYM YYVWGSGLTL 430 440 450 460 470 480 LVVQVSILYY GGHLVISGQM TSGNLIAFII YEFVLGDCME SVGSVYSGLM QGVGAAEKVF 490 500 510 520 530 540 EFIDRQPTMV HDGSLAPDHL EGRVDFENVT FTYRTRPHTQ VLQNVSFSLS PGKVTALVGP 550 560 570 580 590 SGSGKSSCVN ILENFYPLEG GRVLLDGKPI SAYDHKYLHR VVCARAWATL LRPFCI
	Isoform 4 (12B) [UniParc]. Checksum: 840FD3B6FBD9E86B	FASTA	683	75,402
	10 20 30 40 50 60 MRLWKAVVVT LAFMSVDICV TTAIYVFSHL DRSLLEDIRH FNIFDSVLDL WAACLYRSCL 70 80 90 100 110 120 LLGATIGVAK NSALGPRRLR ASWLVITLVC LFVGIYAMVK LLLFSEVRRP IRDPWFWALF 130 140 150 160 170 180 VWTYISLGAS FLLWWLLSTV RPGTQALEPG AATEAEGFPG SGRPPPEQAS GATLQKLLSY 190 200 210 220 230 240 TKPDVAFLVA ASFFLIVAAL GETFLPYYTG RAIDGIVIQK SMDQFSTAVV IVCLLAIGSS 250 260 270 280 290 300 FAAGIRGGIF TLIFARLNIR LRNCLFRSLV SQETSFFDEN RTGDLISRLT SDTTMVSDLV 310 320 330 340 350 360 SQNINVFLRN TVKVTGVVVF MFSLSWQLSL VTFMGFPIIM MVSNIYGKYY KRLSKEVQNA 370 380 390 400 410 420 LARASNTAEE TISAMKTVRS FANEEEEAEV YLRKLQQVYK LNRKEAAAYM YYVWGSGLTL 430 440 450 460 470 480 LVVQVSILYY GGHLVISGQM TSGNLIAFII YEFVLGDCME SVGSVYSGLM QGVGAAEKVF 490 500 510 520 530 540 EFIDRQPTMV HDGSLAPDHL EGRVDFENVT FTYRTRPHTQ VLQNVSFSLS PGKVTALVGP 550 560 570 580 590 600 SGSGKSSCVN ILENFYPLEG GRVLLDGKPI SAYDHKYLHR VISLVSQEPV LFARSITDNI 610 620 630 640 650 660 SYGLPTVPFE MVVEAAQKAN AHGFIMELQD GYSTETGEKG AQLSGGQKQR VAMARALVRN 670 680 PPVLILDEAT SALDAESEYL CAG
	Isoform 5 (12C) [UniParc]. Checksum: ED56FBD9E86BA3D8	FASTA	681	75,284
	10 20 30 40 50 60 MRLWKAVVVT LAFMSVDICV TTAIYVFSHL DRSLLEDIRH FNIFDSVLDL WAACLYRSCL 70 80 90 100 110 120 LLGATIGVAK NSALGPRRLR ASWLVITLVC LFVGIYAMVK LLLFSEVRRP IRDPWFWALF 130 140 150 160 170 180 VWTYISLGAS FLLWWLLSTV RPGTQALEPG AATEAEGFPG SGRPPPEQAS GATLQKLLSY 190 200 210 220 230 240 TKPDVAFLVA ASFFLIVAAL GETFLPYYTG RAIDGIVIQK SMDQFSTAVV IVCLLAIGSS 250 260 270 280 290 300 FAAGIRGGIF TLIFARLNIR LRNCLFRSLV SQETSFFDEN RTGDLISRLT SDTTMVSDLV 310 320 330 340 350 360 SQNINVFLRN TVKVTGVVVF MFSLSWQLSL VTFMGFPIIM MVSNIYGKYY KRLSKEVQNA 370 380 390 400 410 420 LARASNTAEE TISAMKTVRS FANEEEEAEV YLRKLQQVYK LNRKEAAAYM YYVWGSGLTL 430 440 450 460 470 480 LVVQVSILYY GGHLVISGQM TSGNLIAFII YEFVLGDCME SVGSVYSGLM QGVGAAEKVF 490 500 510 520 530 540 EFIDRQPTMV HDGSLAPDHL EGRVDFENVT FTYRTRPHTQ VLQNVSFSLS PGKVTALVGP 550 560 570 580 590 600 SGSGKSSCVN ILENFYPLEG GRVLLDGKPI SAYDHKYLHR VISLVSQEPV LFARSITDNI 610 620 630 640 650 660 SYGLPTVPFE MVVEAAQKAN AHGFIMELQD GYSTETGEKG AQLSGGQKQR VAMARALVRN 670 680 PPVLILDEAT SALDAESEYL I
	Isoform 6 [UniParc]. Checksum: EC9F3DAE5C28F419	FASTA	703	77,470
	10 20 30 40 50 60 MRLWKAVVVT LAFMSVDICV TTAIYVFSHL DRSLLEDIRH FNIFDSVLDL WAACLYRSCL 70 80 90 100 110 120 LLGATIGVAK NSALGPRRLR ASWLVITLVC LFVGIYAMVK LLLFSEVRRP IRDPWFWALF 130 140 150 160 170 180 VWTYISLGAS FLLWWLLSTV RPGTQALEPG AATEAEGFPG SGRPPPEQAS GATLQKLLSY 190 200 210 220 230 240 TKPDVAFLVA ASFFLIVAAL GETFLPYYTG RAIDGIVIQK SMDQFSTAVV IVCLLAIGSS 250 260 270 280 290 300 FAAGIRGGIF TLIFARLNIR LRNCLFRSLV SQETSFFDEN RTGDLISRLT SDTTMVSDLV 310 320 330 340 350 360 SQNINVFLRN TVKVTGVVVF MFSLSWQLSL VTFMGFPIIM MVSNIYGKYY KRLSKEVQNA 370 380 390 400 410 420 LARASNTAEE TISAMKTVRS FANEEEEAEV YLRKLQQVYK LNRKEAAAYM YYVWGSGLTL 430 440 450 460 470 480 LVVQVSILYY GGHLVISGQM TSGNLIAFII YEFVLGDCME NVSFSLSPGK VTALVGPSGS 490 500 510 520 530 540 GKSSCVNILE NFYPLEGGRV LLDGKPISAY DHKYLHRVIS LVSQEPVLFA RSITDNISYG 550 560 570 580 590 600 LPTVPFEMVV EAAQKANAHG FIMELQDGYS TETGEKGAQL SGGQKQRVAM ARALVRNPPV 610 620 630 640 650 660 LILDEATSAL DAESEYLIQQ AIHGNLQKHT VLIIAHRLST VEHAHLIVVL DKGRVVQQGT 670 680 690 700 HQQLLAQGGL YAKLVQRQML GLQPAADFTA GHNEPVANGS HKA

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A half-type ABC transporter TAPL is highly conserved between rodent and man, and the human gene is not responsive to interferon-gamma in contrast to TAP1 and TAP2." Kobayashi A., Kasano M., Maeda T., Hori S., Motojima K., Suzuki M., Fujiwara T., Takahashi E., Yabe T., Tanaka K., Kasahara M., Yamaguchi Y., Maeda M. J. Biochem. 128:711-718(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), INDUCTION. Tissue: Embryonic kidney.
[2]	"Characterization of ABCB9, an ATP binding cassette protein associated with lysosomes." Zhang F., Zhang W., Liu L., Fisher C.L., Hui D., Childs S., Dorovini-Zis K., Ling V. J. Biol. Chem. 275:23287-23294(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), SUBCELLULAR LOCATION, TISSUE SPECIFICITY. Tissue: Lymphoblast.
[3]	"Gene organization of human transporter associated with antigen processing-like (TAPL, ABCB9): analysis of alternative splicing variants and promoter activity." Kobayashi A., Hori S., Suita N., Maeda M. Biochem. Biophys. Res. Commun. 309:815-822(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 4 AND 5). Tissue: Cervix carcinoma and Embryonic kidney.
[4]	"Alternative splice variants encoding unstable protein domains exist in the human brain." Homma K., Kikuno R.F., Nagase T., Ohara O., Nishikawa K. J. Mol. Biol. 343:1207-1220(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Tissue: Brain.
[5]	"Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro." Nagase T., Kikuno R., Ishikawa K., Hirosawa M., Ohara O. DNA Res. 7:143-150(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Brain.
[6]	Ohara O., Nagase T., Kikuno R. Submitted (JAN-2005) to the EMBL/GenBank/DDBJ databases Cited for: SEQUENCE REVISION.
[7]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Trachea.
[8]	"The finished DNA sequence of human chromosome 12." Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R. , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A. Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[9]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3). Tissue: Brain.
[10]	"Membrane localization of transporter associated with antigen processing (TAP)-like (ABCB9) visualized in vivo with a fluorescence protein-fusion technique." Kobayashi A., Maeda T., Maeda M. Biol. Pharm. Bull. 27:1916-1922(2004) [PubMed] [Europe PMC] [Abstract] Cited for: SUBCELLULAR LOCATION, DOMAIN.
[11]	"Selective and ATP-dependent translocation of peptides by the homodimeric ATP binding cassette transporter TAP-like (ABCB9)." Wolters J.C., Abele R., Tampe R. J. Biol. Chem. 280:23631-23636(2005) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, BIOPHYSICOCHEMICAL PROPERTIES, SUBUNIT.
[12]	"Identification of a lysosomal peptide transport system induced during dendritic cell development." Demirel O., Waibler Z., Kalinke U., Grunebach F., Appel S., Brossart P., Hasilik A., Tampe R., Abele R. J. Biol. Chem. 282:37836-37843(2007) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
[13]	"Integral and associated lysosomal membrane proteins." Schroeder B., Wrocklage C., Pan C., Jaeger R., Koesters B., Schaefer H., Elsaesser H.-P., Mann M., Hasilik A. Traffic 8:1676-1686(2007) [PubMed] [Europe PMC] [Abstract] Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY. Tissue: Placenta.
[14]	"Functional dissection of transmembrane domains of human TAP-like (ABCB9)." Kamakura A., Fujimoto Y., Motohashi Y., Ohashi K., Ohashi-Kobayashi A., Maeda M. Biochem. Biophys. Res. Commun. 377:847-851(2008) [PubMed] [Europe PMC] [Abstract] Cited for: SUBCELLULAR LOCATION.
[15]	"Biochemical characterization of transporter associated with antigen processing (TAP)-like (ABCB9) expressed in insect cells." Ohara T., Ohashi-Kobayashi A., Maeda M. Biol. Pharm. Bull. 31:1-5(2008) [PubMed] [Europe PMC] [Abstract] Cited for: SUBCELLULAR LOCATION, DOMAIN.
[16]	"Peptide specificity and lipid activation of the lysosomal transport complex ABCB9 (TAPL)." Zhao C., Haase W., Tampe R., Abele R. J. Biol. Chem. 283:17083-17091(2008) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION.
[17]	"Tuning the cellular trafficking of the lysosomal peptide transporter TAPL by its N-terminal domain." Demirel O., Bangert I., Tampe R., Abele R. Traffic 11:383-393(2010) [PubMed] [Europe PMC] [Abstract] Cited for: SUBCELLULAR LOCATION, DOMAIN, MUTAGENESIS OF 136-LYS-LYS-137.
[18]	"Transporter associated with antigen processing-like (ABCB9) stably expressed in Chinese hamster ovary-K1 cells is sorted to the microdomains of lysosomal membranes." Fujimoto Y., Kamakura A., Motohashi Y., Ohashi-Kobayashi A., Maeda M. Biol. Pharm. Bull. 34:36-40(2011) [PubMed] [Europe PMC] [Abstract] Cited for: SUBCELLULAR LOCATION.
[19]	"Three hundred twenty-six genetic variations in genes encoding nine members of ATP-binding cassette, subfamily B (ABCB/MDR/TAP), in the Japanese population." Saito S., Iida A., Sekine A., Miura Y., Ogawa C., Kawauchi S., Higuchi S., Nakamura Y. J. Hum. Genet. 47:38-50(2002) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANT MET-121.

Web resources

ABCMdb

Database for mutations in ABC proteins

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB045381 mRNA. Translation: BAA97989.2. AF216494 mRNA. Translation: AAF89993.1. AB112582 mRNA. Translation: BAC98409.1. AB112583 mRNA. Translation: BAC98410.1. AB177852 mRNA. Translation: BAD66830.1. Different initiation. AB040953 mRNA. Translation: BAA96044.2. Different initiation. AK304295 mRNA. Translation: BAG65152.1. AC026362 Genomic DNA. No translation available. AC027290 Genomic DNA. No translation available. BC017348 mRNA. Translation: AAH17348.1.
IPI	IPI00216589. IPI00418359. IPI01010415. IPI01014873.
RefSeq	NP_001229942.1. NM_001243013.1. NP_001229943.1. NM_001243014.1. NP_062570.1. NM_019624.3. NP_062571.1. NM_019625.3. NP_982269.2. NM_203444.3.
UniGene	Hs.511951.
3D structure databases
ProteinModelPortal	Q9NP78.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000280560.
PTM databases
PhosphoSite	Q9NP78.
Polymorphism databases
DMDM	22095458.
Proteomic databases
PaxDb	Q9NP78.
PRIDE	Q9NP78.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000280560; ENSP00000280560; ENSG00000150967. ENST00000344275; ENSP00000456813; ENSG00000150967. ENST00000346530; ENSP00000280559; ENSG00000150967. ENST00000392439; ENSP00000376234; ENSG00000150967. ENST00000442833; ENSP00000456375; ENSG00000150967. ENST00000540285; ENSP00000441734; ENSG00000150967. ENST00000542678; ENSP00000440288; ENSG00000150967.
GeneID	23457.
KEGG	hsa:23457.
UCSC	uc001udm.4. human. uc001udo.4. human. uc001udr.3. human.
Organism-specific databases
CTD	23457.
GeneCards	GC12M123413.
HGNC	HGNC:50. ABCB9.
HPA	HPA035114.
MIM	605453. gene.
neXtProt	NX_Q9NP78.
PharmGKB	PA24391.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG1132.
HOVERGEN	HBG008358.
InParanoid	Q9NP78.
KO	K05656.
OrthoDB	EOG4VT5X2.
PhylomeDB	Q9NP78.
Enzyme and pathway databases
BRENDA	3.6.3.43. 2681.
Gene expression databases
ArrayExpress	Q9NP78.
Bgee	Q9NP78.
CleanEx	HS_ABCB9.
Genevestigator	Q9NP78.
GermOnline	ENSG00000150967. Homo sapiens.
Family and domain databases
InterPro	IPR003593. AAA+_ATPase. IPR003439. ABC_transporter-like. IPR017871. ABC_transporter_CS. IPR017940. ABC_transporter_type1. IPR001140. ABC_transptr_TM_dom. IPR011527. ABC_transptrTM_dom_typ1. [Graphical view]
Pfam	PF00664. ABC_membrane. 1 hit. PF00005. ABC_tran. 1 hit. [Graphical view]
SMART	SM00382. AAA. 1 hit. [Graphical view]
SUPFAM	SSF90123. ABC_TM_1. 1 hit.
PROSITE	PS50929. ABC_TM1F. 1 hit. PS00211. ABC_TRANSPORTER_1. 1 hit. PS50893. ABC_TRANSPORTER_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChEMBL	CHEMBL1293189.
GenomeRNAi	23457.
NextBio	45751.
SOURCE	Search...

Entry information

Entry name

ABCB9_HUMAN

Accession

Primary (citable) accession number: Q9NP78
Secondary accession number(s): B4E2J0 , Q5W9G7, Q769F3, Q769F4, Q96AB1, Q9P208

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 2, 2002
Last sequence update:	October 1, 2000
Last modified:	May 1, 2013
This is version 125 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.