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Q9NP78

- ABCB9_HUMAN

UniProt

Q9NP78 - ABCB9_HUMAN

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Protein

ATP-binding cassette sub-family B member 9

Gene

ABCB9

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

ATP-dependent low-affinity peptide transporter which translocates a broad spectrum of peptides from the cytosol to the lysosomal lumen. Displays a broad peptide length specificity from 6-mer up to at least 59-mer peptides with an optimum of 23-mers. Favors positively charged, aromatic or hydrophobic residues in the N- and C-terminal positions whereas negatively charged residues as well as asparagine and methionine are not favored.3 Publications

Kineticsi

  1. KM=6.8 µM for peptide RRYQNSTCL1 Publication

pH dependencei

Optimum pH is 7.0.1 Publication

Temperature dependencei

Optimum temperature is 37 degrees Celsius.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi539 – 5468ATPPROSITE-ProRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB
  2. peptide-transporting ATPase activity Source: UniProtKB
  3. protein homodimerization activity Source: UniProtKB
  4. substrate-specific transmembrane transporter activity Source: UniProtKB

GO - Biological processi

  1. peptide transport Source: UniProtKB
  2. protein transport Source: UniProtKB-KW
  3. transmembrane transport Source: RefGenome
Complete GO annotation...

Keywords - Biological processi

Peptide transport, Protein transport, Transport

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi3.6.3.43. 2681.

Protein family/group databases

TCDBi3.A.1.209.2. the atp-binding cassette (abc) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-binding cassette sub-family B member 9
Alternative name(s):
ATP-binding cassette transporter 9
Short name:
ABC transporter 9 protein
Short name:
hABCB9
TAP-like protein
Short name:
TAPL
Gene namesi
Name:ABCB9
Synonyms:KIAA1520
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 12

Organism-specific databases

HGNCiHGNC:50. ABCB9.

Subcellular locationi

Lysosome membrane 8 Publications; Multi-pass membrane protein 8 PublicationsPROSITE-ProRule annotation
Note: May be located in membrane rafts.

GO - Cellular componenti

  1. integral component of endoplasmic reticulum membrane Source: UniProtKB
  2. integral component of membrane Source: UniProtKB
  3. lysosomal membrane Source: UniProtKB
  4. lysosome Source: UniProt
Complete GO annotation...

Keywords - Cellular componenti

Lysosome, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi136 – 1372LL → AA: No effect on lysosomal localization. 1 Publication

Organism-specific databases

PharmGKBiPA24391.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 766766ATP-binding cassette sub-family B member 9PRO_0000000252Add
BLAST

Proteomic databases

PaxDbiQ9NP78.
PRIDEiQ9NP78.

PTM databases

PhosphoSiteiQ9NP78.

Expressioni

Tissue specificityi

Highly expressed in testis, and at moderate levels in brain, spinal cord, and thyroid. Not expressed in monocytes but strongly expressed during differentiation of monocytes to dendritic cells and macrophages.2 Publications

Inductioni

Not induced by interferon-gamma.1 Publication

Gene expression databases

BgeeiQ9NP78.
CleanExiHS_ABCB9.
ExpressionAtlasiQ9NP78. baseline and differential.
GenevestigatoriQ9NP78.

Organism-specific databases

HPAiHPA035114.

Interactioni

Subunit structurei

Homodimer.1 Publication

Protein-protein interaction databases

BioGridi117021. 1 interaction.
STRINGi9606.ENSP00000280560.

Structurei

3D structure databases

ProteinModelPortaliQ9NP78.
SMRiQ9NP78. Positions 175-739.
ModBaseiSearch...
MobiDBiSearch...

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei7 – 2721HelicalPROSITE-ProRule annotationAdd
BLAST
Transmembranei47 – 6721HelicalPROSITE-ProRule annotationAdd
BLAST
Transmembranei84 – 10421HelicalPROSITE-ProRule annotationAdd
BLAST
Transmembranei116 – 13621HelicalPROSITE-ProRule annotationAdd
BLAST
Transmembranei185 – 20521HelicalPROSITE-ProRule annotationAdd
BLAST
Transmembranei225 – 24521HelicalPROSITE-ProRule annotationAdd
BLAST
Transmembranei319 – 33921HelicalPROSITE-ProRule annotationAdd
BLAST
Transmembranei416 – 43621HelicalPROSITE-ProRule annotationAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini188 – 471284ABC transmembrane type-1PROSITE-ProRule annotationAdd
BLAST
Domaini504 – 740237ABC transporterPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi384 – 3896Poly-Glu

Domaini

The N-terminal region comprising the first four transmembrane domains is required for lysosomal localization but not for homodimerization or peptide transport.3 Publications

Sequence similaritiesi

Contains 1 ABC transmembrane type-1 domain.PROSITE-ProRule annotation
Contains 1 ABC transporter domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1132.
GeneTreeiENSGT00550000074497.
HOVERGENiHBG008358.
InParanoidiQ9NP78.
KOiK05656.
OrthoDBiEOG7Z3F4H.
PhylomeDBiQ9NP78.
TreeFamiTF105197.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR001140. ABC_transptr_TM_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00664. ABC_membrane. 1 hit.
PF00005. ABC_tran. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
SSF90123. SSF90123. 1 hit.
PROSITEiPS50929. ABC_TM1F. 1 hit.
PS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 1 hit.
[Graphical view]

Sequences (6)i

Sequence statusi: Complete.

This entry describes 6 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9NP78-1) [UniParc]FASTAAdd to Basket

Also known as: 12A, c1-l

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRLWKAVVVT LAFMSVDICV TTAIYVFSHL DRSLLEDIRH FNIFDSVLDL
60 70 80 90 100
WAACLYRSCL LLGATIGVAK NSALGPRRLR ASWLVITLVC LFVGIYAMVK
110 120 130 140 150
LLLFSEVRRP IRDPWFWALF VWTYISLGAS FLLWWLLSTV RPGTQALEPG
160 170 180 190 200
AATEAEGFPG SGRPPPEQAS GATLQKLLSY TKPDVAFLVA ASFFLIVAAL
210 220 230 240 250
GETFLPYYTG RAIDGIVIQK SMDQFSTAVV IVCLLAIGSS FAAGIRGGIF
260 270 280 290 300
TLIFARLNIR LRNCLFRSLV SQETSFFDEN RTGDLISRLT SDTTMVSDLV
310 320 330 340 350
SQNINVFLRN TVKVTGVVVF MFSLSWQLSL VTFMGFPIIM MVSNIYGKYY
360 370 380 390 400
KRLSKEVQNA LARASNTAEE TISAMKTVRS FANEEEEAEV YLRKLQQVYK
410 420 430 440 450
LNRKEAAAYM YYVWGSGLTL LVVQVSILYY GGHLVISGQM TSGNLIAFII
460 470 480 490 500
YEFVLGDCME SVGSVYSGLM QGVGAAEKVF EFIDRQPTMV HDGSLAPDHL
510 520 530 540 550
EGRVDFENVT FTYRTRPHTQ VLQNVSFSLS PGKVTALVGP SGSGKSSCVN
560 570 580 590 600
ILENFYPLEG GRVLLDGKPI SAYDHKYLHR VISLVSQEPV LFARSITDNI
610 620 630 640 650
SYGLPTVPFE MVVEAAQKAN AHGFIMELQD GYSTETGEKG AQLSGGQKQR
660 670 680 690 700
VAMARALVRN PPVLILDEAT SALDAESEYL IQQAIHGNLQ KHTVLIIAHR
710 720 730 740 750
LSTVEHAHLI VVLDKGRVVQ QGTHQQLLAQ GGLYAKLVQR QMLGLQPAAD
760
FTAGHNEPVA NGSHKA
Length:766
Mass (Da):84,475
Last modified:October 1, 2000 - v1
Checksum:iC83FA62C929EC792
GO
Isoform 2 (identifier: Q9NP78-2) [UniParc]FASTAAdd to Basket

Also known as: c1-s

The sequence of this isoform differs from the canonical sequence as follows:
     418-460: Missing.

Show »
Length:723
Mass (Da):79,771
Checksum:i8FEB1D7C16C59FBC
GO
Isoform 3 (identifier: Q9NP78-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     582-596: ISLVSQEPVLFARSI → VCARAWATLLRPFCI
     597-766: Missing.

Note: No experimental confirmation available.

Show »
Length:596
Mass (Da):66,238
Checksum:i9A6E46B08EE34D37
GO
Isoform 4 (identifier: Q9NP78-5) [UniParc]FASTAAdd to Basket

Also known as: 12B

The sequence of this isoform differs from the canonical sequence as follows:
     681-683: IQQ → CAG
     684-766: Missing.

Show »
Length:683
Mass (Da):75,402
Checksum:i840FD3B6FBD9E86B
GO
Isoform 5 (identifier: Q9NP78-6) [UniParc]FASTAAdd to Basket

Also known as: 12C

The sequence of this isoform differs from the canonical sequence as follows:
     682-766: Missing.

Show »
Length:681
Mass (Da):75,284
Checksum:iED56FBD9E86BA3D8
GO
Isoform 6 (identifier: Q9NP78-7) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     461-523: Missing.

Note: No experimental confirmation available.

Show »
Length:703
Mass (Da):77,470
Checksum:iEC9F3DAE5C28F419
GO

Sequence cautioni

The sequence BAA96044.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.
The sequence BAD66830.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti121 – 1211V → M.1 Publication
Corresponds to variant rs3803002 [ dbSNP | Ensembl ].
VAR_013701

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei418 – 46043Missing in isoform 2. 1 PublicationVSP_000027Add
BLAST
Alternative sequencei461 – 52363Missing in isoform 6. CuratedVSP_044884Add
BLAST
Alternative sequencei582 – 59615ISLVS…FARSI → VCARAWATLLRPFCI in isoform 3. 1 PublicationVSP_000029Add
BLAST
Alternative sequencei597 – 766170Missing in isoform 3. 1 PublicationVSP_000030Add
BLAST
Alternative sequencei681 – 6833IQQ → CAG in isoform 4. 1 PublicationVSP_041884
Alternative sequencei682 – 76685Missing in isoform 5. 1 PublicationVSP_041885Add
BLAST
Alternative sequencei684 – 76683Missing in isoform 4. 1 PublicationVSP_041886Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB045381 mRNA. Translation: BAA97989.2.
AF216494 mRNA. Translation: AAF89993.1.
AB112582 mRNA. Translation: BAC98409.1.
AB112583 mRNA. Translation: BAC98410.1.
AB177852 mRNA. Translation: BAD66830.1. Different initiation.
AB040953 mRNA. Translation: BAA96044.2. Different initiation.
AK304295 mRNA. Translation: BAG65152.1.
AC026362 Genomic DNA. No translation available.
AC027290 Genomic DNA. No translation available.
BC017348 mRNA. Translation: AAH17348.1.
CCDSiCCDS58286.1. [Q9NP78-7]
CCDS58287.1. [Q9NP78-6]
CCDS58288.1. [Q9NP78-5]
CCDS9241.1. [Q9NP78-1]
RefSeqiNP_001229942.1. NM_001243013.1. [Q9NP78-7]
NP_001229943.1. NM_001243014.1. [Q9NP78-6]
NP_062570.1. NM_019624.3. [Q9NP78-2]
NP_062571.1. NM_019625.3. [Q9NP78-1]
NP_982269.2. NM_203444.3. [Q9NP78-5]
UniGeneiHs.511951.

Genome annotation databases

EnsembliENST00000280560; ENSP00000280560; ENSG00000150967. [Q9NP78-1]
ENST00000344275; ENSP00000456813; ENSG00000150967. [Q9NP78-6]
ENST00000346530; ENSP00000280559; ENSG00000150967. [Q9NP78-2]
ENST00000392439; ENSP00000376234; ENSG00000150967. [Q9NP78-1]
ENST00000442833; ENSP00000456375; ENSG00000150967. [Q9NP78-5]
ENST00000540285; ENSP00000441734; ENSG00000150967. [Q9NP78-7]
ENST00000542678; ENSP00000440288; ENSG00000150967. [Q9NP78-1]
GeneIDi23457.
KEGGihsa:23457.
UCSCiuc001udm.4. human. [Q9NP78-1]
uc001udo.4. human. [Q9NP78-2]
uc001udr.3. human. [Q9NP78-3]
uc010taj.2. human.
uc021rfp.1. human. [Q9NP78-5]

Polymorphism databases

DMDMi22095458.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

ABCMdb

Database for mutations in ABC proteins

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB045381 mRNA. Translation: BAA97989.2 .
AF216494 mRNA. Translation: AAF89993.1 .
AB112582 mRNA. Translation: BAC98409.1 .
AB112583 mRNA. Translation: BAC98410.1 .
AB177852 mRNA. Translation: BAD66830.1 . Different initiation.
AB040953 mRNA. Translation: BAA96044.2 . Different initiation.
AK304295 mRNA. Translation: BAG65152.1 .
AC026362 Genomic DNA. No translation available.
AC027290 Genomic DNA. No translation available.
BC017348 mRNA. Translation: AAH17348.1 .
CCDSi CCDS58286.1. [Q9NP78-7 ]
CCDS58287.1. [Q9NP78-6 ]
CCDS58288.1. [Q9NP78-5 ]
CCDS9241.1. [Q9NP78-1 ]
RefSeqi NP_001229942.1. NM_001243013.1. [Q9NP78-7 ]
NP_001229943.1. NM_001243014.1. [Q9NP78-6 ]
NP_062570.1. NM_019624.3. [Q9NP78-2 ]
NP_062571.1. NM_019625.3. [Q9NP78-1 ]
NP_982269.2. NM_203444.3. [Q9NP78-5 ]
UniGenei Hs.511951.

3D structure databases

ProteinModelPortali Q9NP78.
SMRi Q9NP78. Positions 175-739.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 117021. 1 interaction.
STRINGi 9606.ENSP00000280560.

Chemistry

ChEMBLi CHEMBL1293189.

Protein family/group databases

TCDBi 3.A.1.209.2. the atp-binding cassette (abc) superfamily.

PTM databases

PhosphoSitei Q9NP78.

Polymorphism databases

DMDMi 22095458.

Proteomic databases

PaxDbi Q9NP78.
PRIDEi Q9NP78.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000280560 ; ENSP00000280560 ; ENSG00000150967 . [Q9NP78-1 ]
ENST00000344275 ; ENSP00000456813 ; ENSG00000150967 . [Q9NP78-6 ]
ENST00000346530 ; ENSP00000280559 ; ENSG00000150967 . [Q9NP78-2 ]
ENST00000392439 ; ENSP00000376234 ; ENSG00000150967 . [Q9NP78-1 ]
ENST00000442833 ; ENSP00000456375 ; ENSG00000150967 . [Q9NP78-5 ]
ENST00000540285 ; ENSP00000441734 ; ENSG00000150967 . [Q9NP78-7 ]
ENST00000542678 ; ENSP00000440288 ; ENSG00000150967 . [Q9NP78-1 ]
GeneIDi 23457.
KEGGi hsa:23457.
UCSCi uc001udm.4. human. [Q9NP78-1 ]
uc001udo.4. human. [Q9NP78-2 ]
uc001udr.3. human. [Q9NP78-3 ]
uc010taj.2. human.
uc021rfp.1. human. [Q9NP78-5 ]

Organism-specific databases

CTDi 23457.
GeneCardsi GC12M123413.
HGNCi HGNC:50. ABCB9.
HPAi HPA035114.
MIMi 605453. gene.
neXtProti NX_Q9NP78.
PharmGKBi PA24391.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG1132.
GeneTreei ENSGT00550000074497.
HOVERGENi HBG008358.
InParanoidi Q9NP78.
KOi K05656.
OrthoDBi EOG7Z3F4H.
PhylomeDBi Q9NP78.
TreeFami TF105197.

Enzyme and pathway databases

BRENDAi 3.6.3.43. 2681.

Miscellaneous databases

GeneWikii ABCB9.
GenomeRNAii 23457.
NextBioi 45751.
PROi Q9NP78.
SOURCEi Search...

Gene expression databases

Bgeei Q9NP78.
CleanExi HS_ABCB9.
ExpressionAtlasi Q9NP78. baseline and differential.
Genevestigatori Q9NP78.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
InterProi IPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR001140. ABC_transptr_TM_dom.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF00664. ABC_membrane. 1 hit.
PF00005. ABC_tran. 1 hit.
[Graphical view ]
SMARTi SM00382. AAA. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
SSF90123. SSF90123. 1 hit.
PROSITEi PS50929. ABC_TM1F. 1 hit.
PS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A half-type ABC transporter TAPL is highly conserved between rodent and man, and the human gene is not responsive to interferon-gamma in contrast to TAP1 and TAP2."
    Kobayashi A., Kasano M., Maeda T., Hori S., Motojima K., Suzuki M., Fujiwara T., Takahashi E., Yabe T., Tanaka K., Kasahara M., Yamaguchi Y., Maeda M.
    J. Biochem. 128:711-718(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), INDUCTION.
    Tissue: Embryonic kidney.
  2. "Characterization of ABCB9, an ATP binding cassette protein associated with lysosomes."
    Zhang F., Zhang W., Liu L., Fisher C.L., Hui D., Childs S., Dorovini-Zis K., Ling V.
    J. Biol. Chem. 275:23287-23294(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    Tissue: Lymphoblast.
  3. "Gene organization of human transporter associated with antigen processing-like (TAPL, ABCB9): analysis of alternative splicing variants and promoter activity."
    Kobayashi A., Hori S., Suita N., Maeda M.
    Biochem. Biophys. Res. Commun. 309:815-822(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 4 AND 5).
    Tissue: Cervix carcinoma and Embryonic kidney.
  4. "Alternative splice variants encoding unstable protein domains exist in the human brain."
    Homma K., Kikuno R.F., Nagase T., Ohara O., Nishikawa K.
    J. Mol. Biol. 343:1207-1220(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Brain.
  5. "Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Kikuno R., Ishikawa K., Hirosawa M., Ohara O.
    DNA Res. 7:143-150(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  6. Ohara O., Nagase T., Kikuno R.
    Submitted (JAN-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION.
  7. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Trachea.
  8. "The finished DNA sequence of human chromosome 12."
    Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.
    , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A.
    Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  9. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    Tissue: Brain.
  10. "Membrane localization of transporter associated with antigen processing (TAP)-like (ABCB9) visualized in vivo with a fluorescence protein-fusion technique."
    Kobayashi A., Maeda T., Maeda M.
    Biol. Pharm. Bull. 27:1916-1922(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, DOMAIN.
  11. "Selective and ATP-dependent translocation of peptides by the homodimeric ATP binding cassette transporter TAP-like (ABCB9)."
    Wolters J.C., Abele R., Tampe R.
    J. Biol. Chem. 280:23631-23636(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, BIOPHYSICOCHEMICAL PROPERTIES, SUBUNIT.
  12. "Identification of a lysosomal peptide transport system induced during dendritic cell development."
    Demirel O., Waibler Z., Kalinke U., Grunebach F., Appel S., Brossart P., Hasilik A., Tampe R., Abele R.
    J. Biol. Chem. 282:37836-37843(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  13. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
    Tissue: Placenta.
  14. Cited for: SUBCELLULAR LOCATION.
  15. "Biochemical characterization of transporter associated with antigen processing (TAP)-like (ABCB9) expressed in insect cells."
    Ohara T., Ohashi-Kobayashi A., Maeda M.
    Biol. Pharm. Bull. 31:1-5(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, DOMAIN.
  16. "Peptide specificity and lipid activation of the lysosomal transport complex ABCB9 (TAPL)."
    Zhao C., Haase W., Tampe R., Abele R.
    J. Biol. Chem. 283:17083-17091(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  17. "Tuning the cellular trafficking of the lysosomal peptide transporter TAPL by its N-terminal domain."
    Demirel O., Bangert I., Tampe R., Abele R.
    Traffic 11:383-393(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, DOMAIN, MUTAGENESIS OF 136-LYS-LYS-137.
  18. "Transporter associated with antigen processing-like (ABCB9) stably expressed in Chinese hamster ovary-K1 cells is sorted to the microdomains of lysosomal membranes."
    Fujimoto Y., Kamakura A., Motohashi Y., Ohashi-Kobayashi A., Maeda M.
    Biol. Pharm. Bull. 34:36-40(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.
  19. "Three hundred twenty-six genetic variations in genes encoding nine members of ATP-binding cassette, subfamily B (ABCB/MDR/TAP), in the Japanese population."
    Saito S., Iida A., Sekine A., Miura Y., Ogawa C., Kawauchi S., Higuchi S., Nakamura Y.
    J. Hum. Genet. 47:38-50(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT MET-121.

Entry informationi

Entry nameiABCB9_HUMAN
AccessioniPrimary (citable) accession number: Q9NP78
Secondary accession number(s): B4E2J0
, Q5W9G7, Q769F3, Q769F4, Q96AB1, Q9P208
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 2, 2002
Last sequence update: October 1, 2000
Last modified: October 29, 2014
This is version 142 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3