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Protein

Palmdelphin

Gene

PALMD

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:ENSG00000099260-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Palmdelphin
Alternative name(s):
Paralemmin-like protein
Gene namesi
Name:PALMD
Synonyms:C1orf11, PALML
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:15846. PALMD.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell projection, Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi54873.
OpenTargetsiENSG00000099260.
PharmGKBiPA32925.

Polymorphism and mutation databases

BioMutaiPALMD.
DMDMi74734298.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002625281 – 551PalmdelphinAdd BLAST551

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1
Modified residuei135PhosphoserineCombined sources1
Cross-linki179Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)Combined sources
Modified residuei271PhosphothreonineBy similarity1
Modified residuei321PhosphoserineCombined sources1
Modified residuei370PhosphoserineBy similarity1
Modified residuei384PhosphoserineCombined sources1
Modified residuei385PhosphoserineBy similarity1
Modified residuei498PhosphoserineCombined sources1
Modified residuei515PhosphoserineCombined sources1
Modified residuei520PhosphoserineCombined sources1

Post-translational modificationi

Phosphorylated.By similarity

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ9NP74.
MaxQBiQ9NP74.
PaxDbiQ9NP74.
PeptideAtlasiQ9NP74.
PRIDEiQ9NP74.

PTM databases

iPTMnetiQ9NP74.
PhosphoSitePlusiQ9NP74.

Expressioni

Tissue specificityi

Ubiquitous. Most abundant in cardiac and skeletal muscle.1 Publication

Gene expression databases

BgeeiENSG00000099260.
CleanExiHS_PALMD.
ExpressionAtlasiQ9NP74. baseline and differential.
GenevisibleiQ9NP74. HS.

Organism-specific databases

HPAiHPA017959.

Interactioni

Subunit structurei

Interacts with GLUL.By similarity

Protein-protein interaction databases

BioGridi120221. 10 interactors.
IntActiQ9NP74. 9 interactors.
STRINGi9606.ENSP00000263174.

Structurei

3D structure databases

ProteinModelPortaliQ9NP74.
SMRiQ9NP74.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili12 – 106Sequence analysisAdd BLAST95

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi450 – 459Poly-Glu10

Sequence similaritiesi

Belongs to the paralemmin family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IH2D. Eukaryota.
ENOG411033J. LUCA.
GeneTreeiENSGT00530000063206.
HOGENOMiHOG000115435.
HOVERGENiHBG082103.
InParanoidiQ9NP74.
KOiK16519.
PhylomeDBiQ9NP74.
TreeFamiTF105402.

Family and domain databases

InterProiIPR004965. Paralemmin.
[Graphical view]
PfamiPF03285. Paralemmin. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9NP74-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEEAELVKGR LQAITDKRKI QEEISQKRLK IEEDKLKHQH LKKKALREKW
60 70 80 90 100
LLDGISSGKE QEEMKKQNQQ DQHQIQVLEQ SILRLEKEIQ DLEKAELQIS
110 120 130 140 150
TKEEAILKKL KSIERTTEDI IRSVKVEREE RAEESIEDIY ANIPDLPKSY
160 170 180 190 200
IPSRLRKEIN EEKEDDEQNR KALYAMEIKV EKDLKTGEST VLSSIPLPSD
210 220 230 240 250
DFKGTGIKVY DDGQKSVYAV SSNHSAAYNG TDGLAPVEVE ELLRQASERN
260 270 280 290 300
SKSPTEYHEP VYANPFYRPT TPQRETVTPG PNFQERIKIK TNGLGIGVNE
310 320 330 340 350
SIHNMGNGLS EERGNNFNHI SPIPPVPHPR SVIQQAEEKL HTPQKRLMTP
360 370 380 390 400
WEESNVMQDK DAPSPKPRLS PRETIFGKSE HQNSSPTCQE DEEDVRYNIV
410 420 430 440 450
HSLPPDINDT EPVTMIFMGY QQAEDSEEDK KFLTGYDGII HAELVVIDDE
460 470 480 490 500
EEEDEGEAEK PSYHPIAPHS QVYQPAKPTP LPRKRSEASP HENTNHKSPH
510 520 530 540 550
KNSISLKEQE ESLGSPVHHS PFDAQTTGDG TEDPSLTALR MRMAKLGKKV

I
Length:551
Mass (Da):62,758
Last modified:October 1, 2000 - v1
Checksum:iCC93EAC5ED5625D7
GO
Isoform 2 (identifier: Q9NP74-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-99: MEEAELVKGR...QDLEKAELQI → MASRWNQQRKRTGRDEEAK

Show »
Length:471
Mass (Da):53,254
Checksum:iD5CC2FF395930E9E
GO
Isoform 3 (identifier: Q9NP74-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-175: Missing.

Show »
Length:376
Mass (Da):41,950
Checksum:i26CACB38DBBC9633
GO

Sequence cautioni

The sequence CAC01336 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti248E → K in BAB14946 (PubMed:14702039).Curated1
Sequence conflicti385S → L in CAC01335 (Ref. 4) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05380573H → Q.Corresponds to variant rs11802902dbSNPEnsembl.1
Natural variantiVAR_053806229N → S.Corresponds to variant rs35258980dbSNPEnsembl.1
Natural variantiVAR_053807459E → D.Corresponds to variant rs35317701dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0217861 – 175Missing in isoform 3. 1 PublicationAdd BLAST175
Alternative sequenceiVSP_0217871 – 99MEEAE…AELQI → MASRWNQQRKRTGRDEEAK in isoform 2. 2 PublicationsAdd BLAST99

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ312214 mRNA. Translation: CAC59692.1.
AF262379 mRNA. Translation: AAL33879.1.
AK000278 mRNA. Translation: BAA91047.1.
AK024654 mRNA. Translation: BAB14946.1.
AL390970 mRNA. Translation: CAC01335.1.
AL390971 mRNA. Translation: CAC01336.1. Sequence problems.
AL390972 mRNA. Translation: CAC01337.1.
AL390973 mRNA. Translation: CAC01338.1.
BC012570 mRNA. Translation: AAH12570.1.
CCDSiCCDS758.1. [Q9NP74-1]
RefSeqiNP_060204.1. NM_017734.4. [Q9NP74-1]
UniGeneiHs.483993.

Genome annotation databases

EnsembliENST00000263174; ENSP00000263174; ENSG00000099260. [Q9NP74-1]
ENST00000615664; ENSP00000479820; ENSG00000099260. [Q9NP74-2]
GeneIDi54873.
KEGGihsa:54873.
UCSCiuc001dsg.4. human. [Q9NP74-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ312214 mRNA. Translation: CAC59692.1.
AF262379 mRNA. Translation: AAL33879.1.
AK000278 mRNA. Translation: BAA91047.1.
AK024654 mRNA. Translation: BAB14946.1.
AL390970 mRNA. Translation: CAC01335.1.
AL390971 mRNA. Translation: CAC01336.1. Sequence problems.
AL390972 mRNA. Translation: CAC01337.1.
AL390973 mRNA. Translation: CAC01338.1.
BC012570 mRNA. Translation: AAH12570.1.
CCDSiCCDS758.1. [Q9NP74-1]
RefSeqiNP_060204.1. NM_017734.4. [Q9NP74-1]
UniGeneiHs.483993.

3D structure databases

ProteinModelPortaliQ9NP74.
SMRiQ9NP74.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120221. 10 interactors.
IntActiQ9NP74. 9 interactors.
STRINGi9606.ENSP00000263174.

PTM databases

iPTMnetiQ9NP74.
PhosphoSitePlusiQ9NP74.

Polymorphism and mutation databases

BioMutaiPALMD.
DMDMi74734298.

Proteomic databases

EPDiQ9NP74.
MaxQBiQ9NP74.
PaxDbiQ9NP74.
PeptideAtlasiQ9NP74.
PRIDEiQ9NP74.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000263174; ENSP00000263174; ENSG00000099260. [Q9NP74-1]
ENST00000615664; ENSP00000479820; ENSG00000099260. [Q9NP74-2]
GeneIDi54873.
KEGGihsa:54873.
UCSCiuc001dsg.4. human. [Q9NP74-1]

Organism-specific databases

CTDi54873.
DisGeNETi54873.
GeneCardsiPALMD.
HGNCiHGNC:15846. PALMD.
HPAiHPA017959.
MIMi610182. gene.
neXtProtiNX_Q9NP74.
OpenTargetsiENSG00000099260.
PharmGKBiPA32925.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IH2D. Eukaryota.
ENOG411033J. LUCA.
GeneTreeiENSGT00530000063206.
HOGENOMiHOG000115435.
HOVERGENiHBG082103.
InParanoidiQ9NP74.
KOiK16519.
PhylomeDBiQ9NP74.
TreeFamiTF105402.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000099260-MONOMER.

Miscellaneous databases

ChiTaRSiPALMD. human.
GenomeRNAii54873.
PROiQ9NP74.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000099260.
CleanExiHS_PALMD.
ExpressionAtlasiQ9NP74. baseline and differential.
GenevisibleiQ9NP74. HS.

Family and domain databases

InterProiIPR004965. Paralemmin.
[Graphical view]
PfamiPF03285. Paralemmin. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPALMD_HUMAN
AccessioniPrimary (citable) accession number: Q9NP74
Secondary accession number(s): Q9H7E6
, Q9NPM5, Q9NPM6, Q9NPS0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: October 1, 2000
Last modified: November 2, 2016
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.