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Protein

Palmdelphin

Gene

PALMD

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Palmdelphin
Alternative name(s):
Paralemmin-like protein
Gene namesi
Name:PALMD
Synonyms:C1orf11, PALML
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:15846. PALMD.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell projection, Cytoplasm

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32925.

Polymorphism and mutation databases

BioMutaiPALMD.
DMDMi74734298.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 551551PalmdelphinPRO_0000262528Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineCombined sources
Modified residuei135 – 1351PhosphoserineCombined sources
Modified residuei271 – 2711PhosphothreonineBy similarity
Modified residuei321 – 3211PhosphoserineCombined sources
Modified residuei370 – 3701PhosphoserineBy similarity
Modified residuei384 – 3841PhosphoserineCombined sources
Modified residuei385 – 3851PhosphoserineBy similarity
Modified residuei498 – 4981PhosphoserineCombined sources
Modified residuei515 – 5151PhosphoserineCombined sources
Modified residuei520 – 5201PhosphoserineCombined sources

Post-translational modificationi

Phosphorylated.By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9NP74.
MaxQBiQ9NP74.
PaxDbiQ9NP74.
PRIDEiQ9NP74.

PTM databases

iPTMnetiQ9NP74.
PhosphoSiteiQ9NP74.

Expressioni

Tissue specificityi

Ubiquitous. Most abundant in cardiac and skeletal muscle.1 Publication

Gene expression databases

BgeeiQ9NP74.
CleanExiHS_PALMD.
ExpressionAtlasiQ9NP74. baseline and differential.
GenevisibleiQ9NP74. HS.

Organism-specific databases

HPAiHPA017959.

Interactioni

Subunit structurei

Interacts with GLUL.By similarity

Protein-protein interaction databases

BioGridi120221. 10 interactions.
IntActiQ9NP74. 9 interactions.
STRINGi9606.ENSP00000263174.

Structurei

3D structure databases

ProteinModelPortaliQ9NP74.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili12 – 10695Sequence analysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi450 – 45910Poly-Glu

Sequence similaritiesi

Belongs to the paralemmin family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IH2D. Eukaryota.
ENOG411033J. LUCA.
GeneTreeiENSGT00530000063206.
HOGENOMiHOG000115435.
HOVERGENiHBG082103.
InParanoidiQ9NP74.
KOiK16519.
OrthoDBiEOG7MSMQD.
PhylomeDBiQ9NP74.
TreeFamiTF105402.

Family and domain databases

InterProiIPR004965. Paralemmin.
[Graphical view]
PfamiPF03285. Paralemmin. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9NP74-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEEAELVKGR LQAITDKRKI QEEISQKRLK IEEDKLKHQH LKKKALREKW
60 70 80 90 100
LLDGISSGKE QEEMKKQNQQ DQHQIQVLEQ SILRLEKEIQ DLEKAELQIS
110 120 130 140 150
TKEEAILKKL KSIERTTEDI IRSVKVEREE RAEESIEDIY ANIPDLPKSY
160 170 180 190 200
IPSRLRKEIN EEKEDDEQNR KALYAMEIKV EKDLKTGEST VLSSIPLPSD
210 220 230 240 250
DFKGTGIKVY DDGQKSVYAV SSNHSAAYNG TDGLAPVEVE ELLRQASERN
260 270 280 290 300
SKSPTEYHEP VYANPFYRPT TPQRETVTPG PNFQERIKIK TNGLGIGVNE
310 320 330 340 350
SIHNMGNGLS EERGNNFNHI SPIPPVPHPR SVIQQAEEKL HTPQKRLMTP
360 370 380 390 400
WEESNVMQDK DAPSPKPRLS PRETIFGKSE HQNSSPTCQE DEEDVRYNIV
410 420 430 440 450
HSLPPDINDT EPVTMIFMGY QQAEDSEEDK KFLTGYDGII HAELVVIDDE
460 470 480 490 500
EEEDEGEAEK PSYHPIAPHS QVYQPAKPTP LPRKRSEASP HENTNHKSPH
510 520 530 540 550
KNSISLKEQE ESLGSPVHHS PFDAQTTGDG TEDPSLTALR MRMAKLGKKV

I
Length:551
Mass (Da):62,758
Last modified:October 1, 2000 - v1
Checksum:iCC93EAC5ED5625D7
GO
Isoform 2 (identifier: Q9NP74-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-99: MEEAELVKGR...QDLEKAELQI → MASRWNQQRKRTGRDEEAK

Show »
Length:471
Mass (Da):53,254
Checksum:iD5CC2FF395930E9E
GO
Isoform 3 (identifier: Q9NP74-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-175: Missing.

Show »
Length:376
Mass (Da):41,950
Checksum:i26CACB38DBBC9633
GO

Sequence cautioni

The sequence CAC01336.1 differs from that shown.Contaminating sequence. Potential poly-A sequence.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti248 – 2481E → K in BAB14946 (PubMed:14702039).Curated
Sequence conflicti385 – 3851S → L in CAC01335 (Ref. 4) Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti73 – 731H → Q.
Corresponds to variant rs11802902 [ dbSNP | Ensembl ].
VAR_053805
Natural varianti229 – 2291N → S.
Corresponds to variant rs35258980 [ dbSNP | Ensembl ].
VAR_053806
Natural varianti459 – 4591E → D.
Corresponds to variant rs35317701 [ dbSNP | Ensembl ].
VAR_053807

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 175175Missing in isoform 3. 1 PublicationVSP_021786Add
BLAST
Alternative sequencei1 – 9999MEEAE…AELQI → MASRWNQQRKRTGRDEEAK in isoform 2. 2 PublicationsVSP_021787Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ312214 mRNA. Translation: CAC59692.1.
AF262379 mRNA. Translation: AAL33879.1.
AK000278 mRNA. Translation: BAA91047.1.
AK024654 mRNA. Translation: BAB14946.1.
AL390970 mRNA. Translation: CAC01335.1.
AL390971 mRNA. Translation: CAC01336.1. Sequence problems.
AL390972 mRNA. Translation: CAC01337.1.
AL390973 mRNA. Translation: CAC01338.1.
BC012570 mRNA. Translation: AAH12570.1.
CCDSiCCDS758.1. [Q9NP74-1]
RefSeqiNP_060204.1. NM_017734.4. [Q9NP74-1]
UniGeneiHs.483993.

Genome annotation databases

EnsembliENST00000263174; ENSP00000263174; ENSG00000099260. [Q9NP74-1]
ENST00000615664; ENSP00000479820; ENSG00000099260. [Q9NP74-2]
GeneIDi54873.
KEGGihsa:54873.
UCSCiuc001dsg.4. human. [Q9NP74-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ312214 mRNA. Translation: CAC59692.1.
AF262379 mRNA. Translation: AAL33879.1.
AK000278 mRNA. Translation: BAA91047.1.
AK024654 mRNA. Translation: BAB14946.1.
AL390970 mRNA. Translation: CAC01335.1.
AL390971 mRNA. Translation: CAC01336.1. Sequence problems.
AL390972 mRNA. Translation: CAC01337.1.
AL390973 mRNA. Translation: CAC01338.1.
BC012570 mRNA. Translation: AAH12570.1.
CCDSiCCDS758.1. [Q9NP74-1]
RefSeqiNP_060204.1. NM_017734.4. [Q9NP74-1]
UniGeneiHs.483993.

3D structure databases

ProteinModelPortaliQ9NP74.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120221. 10 interactions.
IntActiQ9NP74. 9 interactions.
STRINGi9606.ENSP00000263174.

PTM databases

iPTMnetiQ9NP74.
PhosphoSiteiQ9NP74.

Polymorphism and mutation databases

BioMutaiPALMD.
DMDMi74734298.

Proteomic databases

EPDiQ9NP74.
MaxQBiQ9NP74.
PaxDbiQ9NP74.
PRIDEiQ9NP74.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000263174; ENSP00000263174; ENSG00000099260. [Q9NP74-1]
ENST00000615664; ENSP00000479820; ENSG00000099260. [Q9NP74-2]
GeneIDi54873.
KEGGihsa:54873.
UCSCiuc001dsg.4. human. [Q9NP74-1]

Organism-specific databases

CTDi54873.
GeneCardsiPALMD.
HGNCiHGNC:15846. PALMD.
HPAiHPA017959.
MIMi610182. gene.
neXtProtiNX_Q9NP74.
PharmGKBiPA32925.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IH2D. Eukaryota.
ENOG411033J. LUCA.
GeneTreeiENSGT00530000063206.
HOGENOMiHOG000115435.
HOVERGENiHBG082103.
InParanoidiQ9NP74.
KOiK16519.
OrthoDBiEOG7MSMQD.
PhylomeDBiQ9NP74.
TreeFamiTF105402.

Miscellaneous databases

ChiTaRSiPALMD. human.
GenomeRNAii54873.
NextBioi57795.
PROiQ9NP74.
SOURCEiSearch...

Gene expression databases

BgeeiQ9NP74.
CleanExiHS_PALMD.
ExpressionAtlasiQ9NP74. baseline and differential.
GenevisibleiQ9NP74. HS.

Family and domain databases

InterProiIPR004965. Paralemmin.
[Graphical view]
PfamiPF03285. Paralemmin. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The paralemmin protein family: identification of paralemmin-2, an isoform differentially spliced to AKAP2/AKAP-KL, and of palmdelphin, a more distant cytosolic relative."
    Hu B., Copeland N.G., Gilbert D.J., Jenkins N.A., Kilimann M.W.
    Biochem. Biophys. Res. Commun. 285:1369-1376(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Muscle.
  2. "PALML, a novel paralemmin-related gene mapping on human chromosome 1p21."
    Andreu N., Escarceller M., Feather S., Devriendt K., Wolf A.S., Estivill X., Sumoy L.
    Gene 278:33-40(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
  4. The European IMAGE consortium
    Submitted (AUG-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Skeletal muscle.
  6. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
    Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
    Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  7. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."
    Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III
    J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-515, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  8. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-135, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  9. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-321 AND SER-520, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  10. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  11. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-384 AND SER-498, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiPALMD_HUMAN
AccessioniPrimary (citable) accession number: Q9NP74
Secondary accession number(s): Q9H7E6
, Q9NPM5, Q9NPM6, Q9NPS0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: October 1, 2000
Last modified: May 11, 2016
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.